plants Communication Piceatannol Is Superior to Resveratrol at Suppressing Adipogenesis in Human Visceral Adipose-Derived Stem Cells In Sil Park 1, Youngjin Han 1 , HyunA Jo 1, Ki Won Lee 1,2,3,4,* and Yong Sang Song 1,5,* 1 Department of Agricultural Biotechnology, Seoul National University, Seoul 08826, Korea;
[email protected] (I.S.P.);
[email protected] (Y.H.);
[email protected] (H.J.) 2 Advanced Institute of Convergence Technology, Seoul National University, Suwon 16229, Korea 3 Bio-MAX Institute, Seoul National University, Seoul 08826, Korea 4 Research & Development Center, BOBSNU Co., Ltd., Suwon 16229, Korea 5 Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 03080, Korea * Correspondence:
[email protected] (K.W.L.);
[email protected] (Y.S.S.) Abstract: Resveratrol (3,40,5-trans-trihydroxystilbene) and piceatannol (3,30,40,5-trans-tetraphydroxy- stilbene) are major stilbene compounds that are predominantly present in various natural foods, such as berries and fruits. Both phytochemical compounds are consumed as dietary supplements to prevent various metabolic diseases and for their anti-aging properties. Adipose-derived stem cells from human visceral adipose tissue (vASCs) are a useful in vitro model for evaluating their adi- pogenic effect. Treatment with resveratrol and piceatannol significantly inhibited lipid accumulation in vASCs. Their effective concentrations were 5, 10, and 20 µM for inhibiting adipogenesis of vASCs. Interestingly, despite the similar chemical structures of the two compounds, piceatannol showed a higher anti-adipogenic effect at 20 µM than resveratrol in vASCs. Moreover, the inhibitory capacity µ of lipid droplet generation was higher for piceatannol at 20 M than that of resveratrol.