Nod-like receptors in infectious diseases
Jong-Hwan Park
Department of Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National University
Nod-like receptors (NLRs) are intracellular, cytoplasmic sensor for microbial components and danger signals. There are 23 NLR family members in humans and at least 34 genes in mice. NLRs are expressed in nonimmune cells including epithelial cells and mesothelial cells as well as immune cells. As first identified NLRs, Nod1 and Nod2 consist of N-terminal caspase recruitment domain (CARD), intermediate nucleotide-binding oligomerization domain (NOD), and C-terminal leucine-rich repeats (LRRs) domain. Nod1 and Nod2 recognize peptidoglycan derivatives, meso-diaminopimelic acid (meso-DAP) and muramyl dipeptide (MDP), respectively. After stimulated by their specific bacterial molecules, Nod1 and Nod2 associate with its adaptor molecule, RICK/Rip2/CARDIAK, through CARD-CARD interaction, which leads to activation of NF-κB and MAPK, followed by induction of numerous genes involved in inflammatory process. In addition, several types of NLRs including NLRC4 and NLRP3 contribute to the activation of inflammasome, resulting in caspase-1 cleavage. This process is essential for maturation of IL-1β and IL-18. We discuss here the role of NLR proteins in inflammatory diseases. CURRICULUM VITAE
Name: Park, Jong-Hwan, Ph.D and DVM Sex: Male Date of Birth: Feb/05/1976 ID number: 760205-*******
1. Business Address: Department of Laboratory Animal Medicine Tel: +82-62-530-2834 College of Veterinary Medicine, Chonnam National University Fax: +82-42-600-6450 77 Yong-Bong ro, Buk-gu C.P: +82-10-4379-6967 Gwangju 500-757, South Korea E-mail: [email protected]
2. Home Address: 1209-dong 103-ho, Neuriul 12 complex Tel: +82-70-8200-6967 184 Gwanjeo Rd, Seo-gu Daejeon, 302-785 South Korea
3. Education
Year Conferring Institution Field Degree
2005. 2. Seoul National University Laboratory Animal Medicine Ph.D
2000. 2. Seoul National University Laboratory Animal Medicine MS
1998. 2. Seoul National University Veterinary Medicine DVM
4. Titles of Thesis Year Titles Degree 2000. 2. Experimental infection of mice with homogenate from a porcine MS stomach infected with tightly spiral bacteria 2005. 2. Pathological characteristics of gastritis induced by Listeria Ph.D monocytogenes infection via intragastric route in mice
5. Employments Duration Institutes Title
2003. 9. - 2005. 4. Laboratory Animal Center, Research Assistant Seoul National University 2005. 5. – 2009. 1. Department of Pathology, Research Fellow University of Michigan (postdoctoral) 2009. 2. – 2010. 2. School of Dentistry, Research Professor Chosun University 2009. 12. – present WCI program Participating KRIBB Researcher 2010. 3. – 2012. 3. Department of Biochemistry Full-time Konyang University Instructor 2012. 04. – 2014. 08 Department of Biochemistry Assistant professor Konyang University 2014. 09 - present Department of Laboratory Animal Medicine, College of Veterinary Assistant professor Medicine, Chonnam National University
6. Awards Date Issuing Institutes Name of Prize College of Veterinary Medicine Baek-lin Research 2004. 11. 5 Seoul National University Encouragement Prize Japanese Association for Laboratory 2010. 05. 13 International Award Animal Science 7. Research projects
연구비 기간 지원기관 연구주제 자격 (천원) 한국연구재단 Helicobacter pylori 감염에 의한 위염 및 위암에 2009. 5. 1 - 책임 (일반연구자지원 관여하는 숙주 면역반응에서Toll-like receptor와 155,820 2012. 4. 30 연구원 사업 – 기본연구) Nod-like receptor signaling의 역할 한국보건산업진흥원 2009. 5. 1 – 구강암의 진행에 미치는 구강 미생물의 영향과 책임 (보건의료연구개발 35,000 2010. 4. 30 Toll-like receptor 및 Nod-like receptor의 역할 연구원 사업) 2009. 12. 1 – 한국연구재단 세부 WCI kinomics 기반 항암연구센터 270,000 2014. 11. 30 (WCI 사업) 책임 한국연구재단 2010. 5. 1 - 전립선의 염증 및 발암 과정을 조절하는 선천면역 책임 (일반연구자지원 144,900 2013. 4. 30 기전 연구: TLR/NLR 신호기전 연구 연구원 사업-신진연구) 2010. 8. 1 – 국방과학연구소 흑사병계열 세균감염에 대항하는 숙주면역 유발 책임 96,500 2012. 12. 31 (순수기초연구사업) 기전에 관한 연구 연구원
2011. 5. 1 – 한국보건산업진흥원 수지상세포 기반 알러지성 천식요법 개발 900,000 세부 2014. 3. 31 (중점연구) (175,000) 책임 한국연구재단 2012. 9. 1 – 다재내성균 Acinetobacter baumannii에 의한 책임 (일반연구자지원 162,150 2015. 8. 31 항생 펩타이드 생성기전 연구 연구원 사업-기본연구) 2012. 9. 1 – 국방과학연구소 Yersinia에 대한 생체 내 방어인자 생성기전 및 책임 395,000 2015. 8. 31 (국제공동연구사업) 효과연구 연구원 한국보건산업진흥원 2013. 7. 1 – 고병원성 한국형 결핵균 K 균주의 핵심 병원성 인자에 900,000 세부 (난치성 결핵 2015. 6. 30 의한 병인면역과 방어면역의 프로그램화 기전 규명 (270,000) 책임 극복기술개발 사업)
* Gray: finished
8. Oral presentation
2010. 05. 12 – 2010. 05. 14: Kyoto Terrsa (Kyoto, Japan) Jong-Hwan Park, Seung-Hyeok Seok, Min-Won Baek, Hui-Young Lee, Dong-Jae Kim, and Jae-Hak Park. Gastric lesions and immune responses caused by long-term infection with Helicobacter heilmannii in C57BL/6 mice. The 57th Annual Meeting of the Japanese Association for Laboratory Animal Science.
2011. 05. 13 – 2011. 05. 14: Grand Hilton Hotel (Seoul, Korea) Jong-Hwan Park. Toll-like receptors and Nod-like receptors in Infection. 2011 The 19th Federation Meeting of Korean Basic Medical Scientists.
2011. 06. 22 – 2011. 06. 24: Hotel Hyundai (Gyeongju, Korea) Jong-Hwan Park. Toll-like receptors and Nod-like receptors in Infection. 2011 International Symposium & Annual Meeting: Translational Research in Microbiology and Biotechnology.
2012. 08. 23 – 2012. 08. 25: Lotte Buyeo Resort (Chungcheongnam-do, Korea) Jong-Hwan Park: TLR signaling in Acinetobacter baumannii infection. 2012 KALAS International Symposium
9. Poster presentation 2010. 08. 19 – 2010. 08. 21: Bexco (Busan, Korea) Min-Jung Kang, Eun-Jung Song, Kyung-Bok Lee, Sang-Muk Oh, and Jong-Hwan Park. TLR2 activation promotes the expression of VEGF in human prostate cancer. 25th KALAS International Symposium.
2011. 02. 12 – 2011. 02. 17: Santa Fe Community Convention Center Eun-Jung Song, Min-Jung Kang, and Jong-Hwan Park. Toll-like receptor 5 mediates the proliferation of gastric cancer cells via ERK-dependent pathway. 40th Keystone Symposia: Cancer Control by Tumor Suppressors and Immune Effectors. Publications
I. International Journals (SCI & SCIE)
I-86. Tae-Hyoun Kim, Sung Jae Shin, Yeong-Min Park, In Duk Jung, Seung-Wook Ryu, Dong-Jae Kim, Jae-Hak Park, Jong-Hwan Park (2015) Critical role of TRIF and MyD88 in Hsp70-mediated activation of dendritic cells. Cytokine, 71(2):139-144.
I-85. Min-Jung Kang, Eun-Jung Song, Bo-Yeon Kim, Dong-Jae Kim and Jong-Hwan Park (2014) Helicobacter pylori induces vascular endothelial growth factor production in gastric epithelial cells through hypoxia-inducible factor-1α-dependent pathway. Helicobacter, 19(6):476-483.
I-84. Yu-Jin Jeong, Min-Jung Kang, Sang-Jin Lee, Chang-Hwan Kim, Jee-Cheon Kim, Tae-Hyoun Kim, Dong-Jae Kim, Donghyun Kim, Gabriel Núñez, and Jong-Hwan Park (2014) Nod2 and Rip2 contribute to innate immune responses in mouse neutrophils. Immunology, 143(2):269-276.
I-83. Jong-Jin Kim, Yun-Ho Hwang, Kyung-Yun Kang, Inbo Kim, Jong-Bae Kim, Jong-Hwan Park, Yung-Choon Yoo, and Sung-Tae Yee (2014) Enhanced dendritic cell maturation by the B-chain of Korean mistletoe lectin (KML-B), a novel TLR4 agonist. International Immunopharmacology, 21(2):309-319.
I-82. Se-Ra Park, Dong-Jae Kim, Seung-Hyun Han, Min-Jung Kang, Jun-Young Lee, Yu-Jin Jeong, Sang-Jin Lee, Tae-Hyoun Kim, Sang-Gun Ahn, Jung-Hoon Yoon, and Jong-Hwan Park (2014) Diverse toll-like receptors mediate cytokines production by Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans in macrophages. Infection and Immunity, 82(5):1914-1920.
I-81. Tae-Hyoun Kim, Yeong-Min Park, Seung-Wook Ryu, Dong-Jae Kim, Jae-Hak Park, and Jong-Hwan Park (2014) Receptor interacting protein 2 (Rip2) is dispensable for OVA-induced airway inflammation in mice. Allergy, Asthma & Immunology Research, 6(2):163-168. I-80. Chang-Hwan Kim, Dong-Jae Kim, Sang-Jin Lee, Yu-Jin Jeong, Min-Jung Kang, Jun-Young Lee, Jin-A Choi, Sun-Jung Kwon, Jae-Hak Park and Jong-Hwan Park (2014) Toll-like receptor 2 promotes bacterial clearance during the initial stage of pulmonary infection with Acinetobacter baumannii. Molecular Medicine Reports, 9(4):1410-1414.
I-79. Jung-Hwan Park, Yu-Jin Jeong, Hee Kwan Won, Sang-Yun Choi, Jong-Hwan Park, Sang-Muk Oh (2014) Activation of TOPK by lipopolysaccharide promotes induction of inducible nitric oxide synthase through NF-κB activity in leukemia cells. Cellular Signalling, 26(5):849-856.
I-78. Ki Bum Ahn, Jun Ho Jeon, Jung Eun Baik, Ok-Jin Park, Seok-Seong Kang, Cheol-Heui Yun, Jong-Hwan Park, and Seung Hyun Han (2014) Muramyl dipeptide potentiates staphylococcal lipoteichoic acid induction of cyclooxygenase-2 expression in macrophages. Microbes and Infection, 16(2):153-160.
I-77. , , , , , , , , , , , Jong-Hwan Park* (Co-corresponding author), * (2013) Human Umbilical Cord Blood Mesenchymal Stem Cells Reduce Colitis in Mice by Activating NOD2 Signaling to COX2. Gastroenterology, 145(6):1392-1403.
I-76. Yu-Jin Jeong, Chang-Hwan Kim, Jee-Cheon Kim, Sang-Muk Oh, Kyung-Bok Lee, Jong-Hwan Park* (Co-corresponding author), and Dong-Jae Kim* (2013) RIP2/RICK-dependent cytokine production upon Yersinia enterocolitica infection in macrophages with TLR4-deficiency. Scandinavian Journal of Immunology, 78(5):401-407.
I-75. Dong-Jae Kim*, Jong-Hwan Park* (co-first author), Luigi Franchi, Steffen Backert and Gabriel Núñez (2013) The Cag pathogenicity island and interaction between TLR2/NOD2 and NLRP3 regulate IL-1β production in Helicobacter pylori infected dendritic cells. European Journal of Immunology, 43(10):2650-2658.
I-74. Jong-Seok Kim, Woo Sik Kim, Han-Gyu Choi, Byungki Jang, Keehoon Lee, Jong-Hwan Park, Hwa-Jung Kim, Sang-Nae Cho, and Sung Jae Shin (2013) Mycobacterium tuberculosis RpfB drives Th1-type T cell immunity via a TLR4-dependent activation of dendritic cells. Journal of Leukocyte Biology, 94(4):733-749.
I-73 MY Ahn, H-E Yoon, J-H Park, J Lee, S-K Min, S-G Ahn, J-H Yoon (2013) Characterization of NODs and TLRs in innate immune response of human cementoblast cells. Oral Diseases, 19(4):374-380.
I-72. Ju-Hee Han, Shin-Young Park, Jin-Bum Kim, Sung-Dae Cho, Bumseok Kim, Bo-Yeon Kim, Min-Jung Kang, Dong-Jae-Kim, Jae-Hak Park, and Jong-Hwan Park (2013) TLR7 expression is decreased during tumor progression in TRAMP mice and its activation inhibits growth of prostate cancer cells. American Journal of Reproductive Immunology, 70(4):317-326.
I-71. Sung J. Kim, Ji W. Lee, Eui-do Yeo, Seong-Lan Yu, Woo-Sean Jean, Jeong-Hwan Kim, Chang-Gyo Park, Hoi Y. Lee, Seung-Yun Han, Jong-Hwan Park, Byung-Yi Ko and Jaegu Kang (2013) The role of Nod1 signaling in coreal neovascularization. Corenea 32(5):674-679.
I-70. Ju-Hee Han, Junglim Lee, Soo-Jin Jeon, Eun-Sun Choi, Sung-Dae Cho, Bo-Yeon Kim, Dong-Jae Kim, Jae-Hak Park and Jong-Hwan Park (2013) In vitro and in vivo growth inhibition of prostate cancer by the small molecule imiquimod. International Journal of Oncology 42(6): 2087-2093.
I-69. Chang-Hwan Kim, Yu-Jin Jeong, Junglim Lee, Soo-Jin Jeon, Se-Ra Park, Min-Jung Kang, Jae-Hak Park, Jong-Hwan Park (2013) Essential role of Toll-like receptor 4 in Acinetobacter baumannii-induced immune responses in immune cells. Microbial Pathogenesis, 54:20-25.
I-68. Tae-Hyoun Kim, Kyung-Bok Lee, Min-Jung Kang, and Jong-Hwan Park (2012) Critical role of Toll-like receptor 2 in Bacteroides fragilis-mediated immune responses in murine peritoneal mesothelial cells. Microbiology and Immunology, 56(11):782-788.
I-67 Seung-Wook Ryu, Kyungsun Choi, Jong-Hwan Park, Yeong-Min Park, Sunchang Kim, and Chulhee Choi (2012) Mitofusin 1 inhibits an apoptosis-associated amino-terminal conformational change in Bax, but not its mitochondrial translocation, in a GTPase-dependent manner. Cancer Letters, 323(1):62-68.
I-66. Mee-Young Ahn, Seong-Min Kwon, Hak Hyun Cheong, Jong-Hwan Park, Jun Lee, Seung-Ki Min, Sang-Gun Ahn, Jung-Hoon Yoon (2012) Toll-like receptor 7 agonist, Imiquimod, inhibits oral squamous carcinoma cells through apoptosis and necrosis. Journal of Oral Pathology and Medicine, 41(7):540-546.
I-65. Yu-Jin Jeong, Chang-Hwan Kim, Eun-Jung Song, Min-Jung Kang, Jee-Cheon Kim, Sang-Muk Oh, Kyung-Bok Lee, and Jong-Hwan Park (2012) Nucleotide-Binding Oligomerization Domain 2 (Nod2) Is Dispensable for the Innate Immune Responses of Macrophages against Yersinia enterocolitica. Journal of Microbiology, 50(3): 489-495.
I-64. Jong-Hwan Park, Mee-Young Ahn, Yong-Chul Kim, Soo-A Kim, Yeon-Hee Moon, Sang-Gun Ahn and Jung-Hoon Yoon (2012) In Vitro and in Vivo antimicrobial effect of photodynamic therapy using a highly pure chlorin e6 against Staphylococcus aureus Xen29. Biological and Pharmaceutical Bulletin, 35(4):509-514.
I-63. Amanda Weyers, Bo Yang, Dae Sung Yoon, Jong-Hwan Park, Fuming Zhang, Kyung Bok Lee, and Robert J. Linhardt (2012) A structural analysis of glycosaminoglycans from lethal and nonlethal breast cancer tissues: toward a novel class of theragnostics for personalized medicine in oncology? OMICS: A Journal of Integrative Biology, 16(3):79-89.
I-62. Min-Jung Kang, Sook-Kyoung Heo, Eun-Jung Song, Dong-Jae Kim, Seung-Yun Han, Ju-Hee Han, Bo-Yeon Kim, and Jong-Hwan Park (2012) Activation of Nod1 and Nod2 induces innate immune responses of prostate epithelial cells. Prostate, 72(12):1351-1358.
I-61. Do-In Jeon, Se-Ra Park, Mee-Young Ahn, Sang-Gun Ahn, Jong-Hwan Park (Co-corresponding), and Jung-Hoon Yoon (2012). NOD1 and NOD2 stimulation triggers innate immune responses of human periodontal ligament cells. International Journal of Molecular Medicine, 29(4):699-703. I-60. Jong-Hwan Park, Do-In Jeon, Hyo-Eun Yoon, Seong-Min Kwon, Soo-A Kim, Sang-Gun Ahn, and Jung-Hoon Yoon (2012). Poly I:C inhibits cell proliferation and enhances the growth inhibitory effect of paclitaxel in oral sqaumous cell carcinoma. Acta Odontologica Scandinavica, 70(3):241-245.
I-59. Yun-Gi Kim, Michael H. Shaw, Neil Warner, Jong-Hwan Park, Felicia Chen, Yasunori Ogura, and Gabriel Nunez (2011). Crohn’s disease-associated Nod2 mutation limits production of proinflammatory cytokines to protect host from Enterococcus faecalis-induced lethality. Journal of Immunology, 187(6):2849-2852.
I-58. Yun-Gi Kim, Jong-Hwan Park, Thornik Reimer, Darren P. Baker, Taro Kawai, Himanshu Kumar, Shizuo Akira, Christiane Wobus, and Gabriel Nunez (2011). Viral Infection Augments Nod1/2 Signaling to Potentiate Lethality Associated with Secondary Bacterial Infections. Cell Host & Microbe, 9(6):496-507.
I-57. Eun-Jung Song, Min-Jung Kang, Yong-Seok Kim, Sun-Moon Kim, Sang-Eok Lee, Chang-Hwan Kim, Dong-Jae Kim, and Jong-Hwan Park (2011). Flagellin promotes the proliferation of gastric cancer cells via the Toll-like receptor 5. International Journal of Molecular Medicine, 28:115-119.
I-56. Han Geun Kim, Seung Yeon Lee, Na Ra Kim, Hea Young Lee, Mi Yeon Ko, Bong Jun Jung,Chul Min Kim, Jung Min Lee, Jong-Hwan Park, Seung Hyun Han, and Dae Kyun Chung (2011). Lactobacillus plantarum lipoteichoic acid down-regulated Shigella flexneri peptidoglycan-induced inflammation. Molecular Immunology, 48(4):382-391.
I-55. Michelle N. Brooks, Murugesan V. S. Rajaram, Abul K. Azad, Amal O. Amer, Martin A. Valdivia-Arenas, Jong-Hwan Park, Gabriel Nunez, and Larry S. Schlesinger (2011). NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages. Cellular Microbiology, 13(3):402-418.
I-54. Jong-Hwan Park, Hyo-Eun Yoon, Dong-Jae Kim, Soo-A Kim, Sang-Gun Ahn, and Jung-Hoon Yoon (2011). Toll-like receptor 5 activation promotes migration and invasion of salivary gland adenocarcinoma. Journal of Oral Pathology and Medicine, 40(2):187-193.
I-53. Jong-Hwan Park, Seong-Min Kwon, Hyo-Eun Yoon, Soo-A Kim, Sang-Gun Ahn, and Jung-Hoon Yoon (2011). Lipopolysaccharide promotes adhesion and migration of murine dental papilla-derived MDPC-23 cells via TLR4. International Journal of Molecular Medicine, 27(2):277-281.
I-52. Hyung-Sik Kim, Tae-Hoon Shin, Se-Ran Yang, Min-Soo Seo, Dong-Jae Kim, Soo-Kyung Kang, Jong-Hwan Park (co-corresponding author) and Kyung-Sun Kang (2010). Implication of NOD1 and NOD2 for the differentiation of multipotent mesenchymal stem cells derived from human umbilical cord blood. PLoS One, 5(10):e15369.
I-51. Jong-Hwan Park, Hyo-Eun Yoon, Do-In Jeon, Sang-Gun Ahn, and Jung-Hoon Yoon (2010). Activation of TLR2 and TLR5 did not affect tumor progression of an oral squamous cell carcinoma, YD-10B cells. Journal of Oral Pathology & Medicine, 39(10):781-785.
I-50. Jong-Hwan Park, Ji-Hye Yoon, Young-Sin Lim, Ho-Keel Hwang, Soo-A Kim, Sang-Gun Ahn, and Jung-Hoon Yoon (2010). TAT-Hsp27 promotes adhesion and migration of murine dental papilla-derived MDPC-23 cells through β1 integrin-mediated signaling. International Journal of Molecular Medicine, 26(3):373-378.
I-49. Jong-Hwan Park, Yeon-Hee Moon, Dong-Jae kim, Soo-A Kim, Jee-Bum Lee, Sang-Gun Ahn, and Jung-Hoon Yoon (2010). Photodynamic therapy with hexenyl ester of 5-aminolevulinic acid induces necrotic cell death in salivary gland adenocarcinoma cells. Oncology Reports, 24(1):177-181.
I-48. Jong-Hwan Park, Yeon-Hee Moon, Iel-Soo Bang, Yong-Chul Kim, Soo-A Kim, Sang-Gun Ahn, and Jung-Hoon Yoon (2010) Antimicrobial effect of photodynamic therapy using a highly pure chlorin e6. Lasers in Medical Science, 25:705-710.
I-47. Jong-Hwan Park, Ji-Hye Yoon, Soo-A Kim, Sang-Gun Ahn, and Jung-Hoon Yoon (2010) (-)-Epigallocatechin-3-gallate inhibits invasion and migration of salivary gland adenocarcinoma cells. Oncology Reports, 23(2):585-590.
I-46. Ji-Hye Yoon, Soo-A Kim, Jae-Il Kim, Jong-Hwan Park, Sang-Gun Ahn, Jung-Hoon Yoon (2010) Inhibition of invasion and migration of salivary gland adenocarcinoma cells by 5'-nitro-indirubinoxime (5'-NIO). Head and Neck, 32(5):619-625.
I-45. Yeon-Hee Moon, Jong-Hwan Park, Soo-A Kim, Jee-Bum Lee, Sang-Gun Ahn, and Jung-Hoon Yoon (2010) Anticancer effect of photodynamic therapy with hexenyl ester of 5-aminolevulinic acid in oral squamous cell carcinoma. Head and Neck, 32:1136-1142.
I-44. Ji-Hye Yoon, Seong-Min Kwon, Jong-Hwan Park, Soo-A Kim, Hee-Sae Park, Yong-Chul Kim, Jung-Hoon Yoon and Sang-Gun Ahn (2009) 5'-nitro-indirubinoxime induces G1 cell cycle arrest and apoptosis in salivary gland adenocarcinoma cells through the inhibition of Notch-1 signaling. Biochimica et biophysica acta, 1800(3):352-358.
I-43. Yeon-Hee Moon, Seong-Min Kwon, Hyo-Jun Kim, Kwan-Young Jung, Jong-Hwan Park, Soo-A Kim, Yong-Chul Kim, Sang-Gun Ahn, Jung-Hoon Yoon (2009) Efficient preparation of highly pure chlorin e6 and its photodynamic anti-cancer activity in a rat tumor model. Oncology Reports, 22(5):1085-1091.
I-42. Jürgen Harder, Luigi Franchi, Raúl Muñoz-Planillo, Jong-Hwan Park, Thornik Reimer, and Gabriel Núñez (2009) Activation of the Nlrp3 Inflammasome by Streptococcus pyogenes Requires Streptolysin O and NF-{kappa}B Activation but Proceeds Independently of TLR Signaling and P2X7 Receptor. Journal of Immunology, 183:5823-5829.
I-41. Jong-Hwan Park, Yun-gi Kim, and Gabriel Núñez (2009) RICK promotes inflammation and lethality after gram-negative bacterial infection in mice stimulated with lipopolysaccharide. Infection and Immunity, 77(4):1569-1578.
I-40. Tatjana Eigenbrod, Jong-Hwan Park, Jürgen Harder, Yoichiro Iwakura and Gabriel Núñez (2008) Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1alpha released from dying cells. Journal of Immunology, 181:8194-8198.
I-39. Jong-Hwan Park, Seung-Hyeok Seok, Min-Won Baek, Hui-Young Lee, Dong-Jae Kim, and Jae-Hak Park (2008) Gastric lesions and immune responses caused by long-term infection of Helicobacter heilmannii in C57BL/6 mice. Journal of Comparative Pathology, 139(4):208-217.
I-38. Yun-Gi Kim, Jong-Hwan Park, Stephanie Daignault, Koichi Fukase, and Gabriel Nunez (2008) Cross-Tolerization between Nod1 and Nod2 Signaling Results in Reduced Refractoriness to Bacterial Infection in Nod2-Deficient Macrophages. Journal of Immunology, 181:4340-4346.
I-37. Seung-Hyeok Seok, Jong-Hwan Park, Sun-A. Cho, Dong-Jae Kim, Bo-Kyoung Bae, Jae-Hak Park (2008) Risk assessment of the organophosphate pesticides isazofos and pyraclofos using a 21-day dietary toxicity study in Japanese quail. Ecotoxicology and Environmental Safety, 71:245-251.
I-36. Yun-Gi Kim, Jong-Hwan Park, Michael H. Shaw, Luigi Franchi, Naohiro Inohara, and Gabriel Núñez (2008) The Cytosolic Sensors Nod1 and Nod2 Are Critical for Bacterial Recognition and Host Defense after Exposure to Toll-like Receptor Ligands. Immunity, 28:246-257.
I-35. Luigi Franchi, Jong-Hwan Park, Michael H. Shaw, Noemi Marina-Garcia, Grace Chen, Yun-Gi Kim and Gabriel Núñez (2008) Intracellular NOD-like receptors in innate immunity, infection and disease. Cellular Microbiology, 10(1):1-8.
I-34. Jong-Hwan Park, Yun-Gi Kim, Michael Shaw, Thirumala-Devi Kanneganti, Yukari Fujimoto, Koichi Fukase, Naohiro Inohara, and Gabriel Núñez (2007) Nod1/RICK and TLR Signaling Regulate Chemokine and Antimicrobial Innate Immune Responses in Mesothelial Cells. Journal of Immunology, 179(1):514-521. I-33. Thirumala-Devi Kanneganti, Mohamed Lamkanfi, Jong-Hwan Park, Grace Chen, Yungi-Kim, Luigi Franchi, Peter Vandenabeele, and Gabriel Núñez (2007) Pannexin-1-mediated recognition of bacterial PAMPs activates the Cryopyrin/Nalp3 inflammasome independent of TLR signaling. Immunity, 26(4):433-443.
I-32. Jong-Hwan Park, Yun-Gi Kim, Christine McDonald, Thirumala-Devi Kanneganti, Mizuho Hasegawa, Mathilde Body-Malapel, Naohiro Inohara, and Gabriel Núñez (2007) RICK/RIP2 Mediates Innate Immune Responses Induced through Nod1 and Nod2 but Not TLRs. Journal of Immunology, 178(4):2380-2386.
I-31. Hui-Young Lee, Sun-A Cho, In-Soo Lee, Jong-Hwan Park, Seung-Hyeok Seok, Min-Won Baek, Dong-Jae Kim, Seok-Ho Lee, Sook-Jin Hur, Sang-Ja Ban, Yoo-Kyoung Lee, Yang-Keum Han, Young-Keun Cho and Jae-Hak Park (2007) Evaluation of phoP and rpoS mutants of Salmonella enterica serovar Typhi as attenuated typhoid vaccine candidates: virulence and protective immune responses in intranasally immunized mice. FEMS Immunol Med Microbiol, 51:310-318.
I-30. Jong-Hwan Park, Seung-Hyeok Seok, Min-Won Baek, Hui-Young Lee, Dong-Jae Kim, Jung-Sik Cho, Chuel-Kyu Kim, Dae-Youn Hwang, and Jae Hak Park (2006) Microbiological monitoring of guinea pigs reared conventionally at two breeding facilities in Korea. Experimental Animals, 55(5):427-432.
I-29. Thirumala-Devi Kanneganti, Mathilde Body-Malapel, Amal Amer, Jong-Hwan Park, Joel Whitfield, Luigi Franchi, Zenobia F. Taraporewala, David Miller, John T. Patton, Naohiro Inohara, and Gabriel Núñez (2006) Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA. Journal of Biological Chemistry, 281(48):36560-36568.
I-28. Mizuho Hasegawa, Kangkang Yang, Masahito Hashimoto, Jong-Hwan Park, Yun-Gi Kim, Yukari Fujimoto, Gabriel Nuñez, Koichi Fukase, and Naohiro Inohara (2006) Differential Release and Distribution of Nod1 and Nod2 Immunostimulatory Molecules among Bacterial Species and Environments. Journal of Biological Chemistry, 281(39):29054-29063. I-27. Parjeet K. Boughan, Richard H. Argent, Mathilde Body-Malapel, Jong-Hwan Park, Katie E. Ewings, Andrew G. Bowie, Shao Jin Ong, Simon J. Cook, Ole E. Sorensen, Barbara A. Manzo, Naohiro Inohara Nigel J. Klein, Gabriel Nuñez, John C. Atherton, and Mona Bajaj-Elliott (2006) Nucleotide-binding Oligomerization Domain-1 and Epidermal Growth Factor Receptor Critical Regulators of -defensins during Helicobacter pylori infection. Journal of Biological Chemistry, 281(17):11637-11648.
I-26. Thirumala-Devi Kanneganti, Nesrin Özören, Mathilde Body-Malapel, Amal Amer, Jong-Hwan Park, Luigi Franchi, Joel Whitfield, Winfried Barchet, Marco Colonna, Peter Vandenabeele, John Bertin, Anthony Coyle, Ethan P. Grant, Shizuo Akira, and Gabriel Núñez (2006) Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature, 440:233-236.
I-25. Seung-Hyeok Seok, Hye Cheong Koo, Asako Kasuga, Yeun Kim, Eun Gae Lee, Hyeyoung Lee, Jong-Hwan Park, Min-Won Baek, Hui-Young Lee, Dong-Jae Kim, Byeung-Hee Lee, Yong-Soon Lee, Sang-Nae Cho, and Jae-Hak Park (2006) Use of PCR-restriction fragment length polymorphism for the identification of zoonotic mycobacteriosis in zebrafish caused by Mycobacterium abscessus and Mycobacterium chelonae. Veterinary Microbiology, 114:292-297.
I-24. Hui-Young Lee, Jong-Hwan Park, Seung-Hyeok Seok, Min-Won Baek, Dong-Jae Kim, Ki-Eun Lee, Kyung-Soo Paek, Yeonhee Lee, and Jae-Hak Park (2006) Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1761(7):736-744.
I-23. Seung-Hyeok Seok, Jong-Hwan Park, Min-Won Baek, Hui-Young Lee, Dong-Jae Kim, Hyung-Min Uhm, Jung-Joo Hong, Yi-Rang Na, Bo-Hwan Jin, Doug-Young Ryu, and Jae-Hak Park (2006) Specific activation of the human HSP70 promoter by copper sulfate in mosaic transgenic zebrafish. 6(10):406-413. I-22. Sun-A Cho, Jong-Hwan Park, Seung-Hyeok Seok, Jae-Hyeon Juhn, Seong-Jin Kim, Hyi-Jeong Ji, Youn-Sung Choo, and Jae-Hak Park (2006) Effect of granulocyte macrophage-colony stimulating factor (GM-CSF) on 5-FU-induced ulcerative mucositis in hamster buccal pouches. Experimental and Toxicologic Pathology, 57(6):321-328.
I-21. Jong-Hwan Park, Seung-Hyeok Seok, Sun-A Cho, Min-Won Baek, Hui-Young Lee, Dong-Jae Kim, Myung-June Chung, Soo-Dong Kim, Un-Pyo Hong and Jae-Hak Park (2005) Antimicrobial effect of lactic acid producing bacteria culture condensate mixture (LCCM) against Salmonella enteritidis. International Journal of Food Microbiology, 101(1):111-117.
I-20. Jong-Hwan Park, Yeonhee Lee, Seung-Hyeok Seok, Min-Won Baek, Hui-Young Lee, Dong-Jae Kim, Chang-Hwan Kim, and Jae-Hak ParkSafety assessment of Lactobacillus fermentum PL9005, a potential probiotic lactic acid bacterium, in mice. Journal of Microbiology and Biotechnology, 15(3):603-608.
I-19. Jong-Hwan Park, Yeonhee Lee, Enpyo Moon, Seung-Hyeok Seok, Sun-A Cho, Min-Won Baek, Hui-young Lee, Dong-Jae Kim, and Jae-Hak Park (2005) Immunoenhancing effects of a new probiotic strain Lactobacillus fermentum PL9005. Journal of Food Pretection, 68(3):571-576.
I-18. Hui-Young Lee, Jong-Hwan Park, Seung-Hyeok Seok, Min-Won Baek, Dong-Jae Kim, Byoung-Hee Lee, Pil-Don Kang, Yong-Soon Kim, and Jae-Hak Park (2005) Potential antimicrobial effects of human lactoferrin against oral infection with Listeria monocytogenes in mice. Journal of Medical Microbiology, 54:1049-1054.
I-17. Dong-Jae Kim, Jong-Hwan Park, Seung-Hyeok Seok, Sun-A Cho, Min-Won Baek, Hui-Young Lee, and Jae-Hak Park (2005) Epitheliocystis in Carp (Cyprinus carpio) in South Korea. Journal of Veterinary Medical Science, 67(1):119-120.
I-16. Differential identification of Mycoplasma pulmonis and Mycoplasma arthritidis using PCR-based RFLP. Experimental Animal, 54(4):359-362. I-15. Safety and Immunogenicity of Salmonella enterica Serovar Typhimurium llaB in Mice.:609-615.
I-14. Seung-Hyeok Seok, Jong-Hwan Park, Sun-A Cho, Min-Won Baek, Hui-Young Lee, DongJae Kim, Ki-Hwa Yang, Dong-Deuk Jang, Beom-Seok Han, Ki-Taek Nam, and Jae-Hak Park (2005) Health surveillance of specific pathogen-free and conventionally-housed mice and rats in Korea. Experimental Animals, 54(1) 93-95.
I-13. Jong-Hwan Park, Yong-Ho Park, Seung-Hyeok Seok, Sun_A Cho, Min-Won Baek, Hui-Young Lee, Dong-Jae Kim, and Jae-Hak Park (2004) Characteristics of the gastritis induced by Listeria monocytogenes in mice: Microbiology, histopathology, and mRNA expression of inflammatory mediators with time course of infection. Microbial Pathogenesis 37:87-94.
I-12. Jong–Hwan Park, Yong-Ho Park, Seung-Hyeok Seok, Sun-A Cho, Dong-Jae Kim, Hui-Young Lee, So-Hyun Kim, and Jae Hak Park (2004). Suppurative gastritis in BALB/c mice infected with Listeria monocytogenes via the intragastric route. Journal of Comparative Pathology, 130:130-136.
I-11. Jong–Hwan Park, Seung-Hyeok Seok, Sun-A Cho, Min-Won Baek, Hui-Young Lee, Dong-Jae Kim, and Jae Hak Park (2004). The high prevalence of Helicobacter sp. in porcine pyloric mucosa and its histopathological and molecular characteristics. Veterinary Microbiology, 104:219-225.
I-10. Jong-Hwan Park, Seung-Hyeok Seok, Sun-A Cho, Min-Won Baek, Hui-Young Lee, Dong-Jae Kim, Han-Yun Kim, Se-Ok Chang, and Jae Hak Park (2004). Safety and protective effect of a disinfectant (STEL water) for white spot syndrome viral infection in shrimp. Diseases of Aquatic Organisms, 60:253-257.
I-9. Seung-Hyeok Seok, DukWoong Park, Jong-Hwan Park, Sun-A Cho, Min-Won Baek, Hui-Young Lee, Dong-Jae Kim, BoHwan Jin, Doug-Young RYU, and Jae-Hak Park (2004) β-naphthoflavone caused upregulation of AhR regulated GFP in transgenic zebrafish. Experimental Animals, 53(5):479-483.
I-8. Hui-Young Lee, Jong-Hwan Park, Seung-Hyeok Seok, Sun-A Cho, Min-Won Baek, Dong-Jae Kim, Yeonhee Lee, and Jae-Hak Park (2004) Dietary intake of various lactic acid bacteria suppresses type 2 helper T cell production in antigen-primed mice splenocyte. Journal of Microbiology and Biotechnology, 14(1):167-170.
I-7. Seung-Hyeok Seok, Jong-Hwan Park, Sun-A Cho, Song-Am Choi, and Jae-Hak Park (2004) Cholesterol lowering effect of SG-GN3, the extract of salted and fermented small shrimps, Acetes japonicus, in Triton WR-1339 or high cholesterol-diet induced hypercholesterolemic rats. Journal of Ethnopharmacology, 91:231-235.
I-6. Seung-Hyeok Seok, Jong-Hwan Park, Sun-A Cho, Min-Won Baek, Hui-Young Lee, Dong-Jae Kim, and Jae-Hak Park (2004). Cloning and sequencing of envelope proteins (VP19, VP28) and nucleocapsid proteins (VP15, VP35) of a white spot syndrome virus isolate from Korean shrimp. Diseases of Aquatic Organisms, 60:85-88.
I-5. Jong-Hwan Park, Jung-Joo Hong, and Jae-Hak Park. (2003) Experimental infection of mice with tightly coiled spiral bacteria (“Candidatus Helicobacter suis”) originating from the pig stomach. Journal of Comparative Pathology, 129:154-160.
I-4. So-Hyun Kim, Soo-Jin Yang, Hye-Cheong Koo, Won-Ki Bae, Ji-Yeon Kim, Jong-Hwan Park, Young-Jin Baek, and Yong-Ho Park (2001). Inhibitory activity of Bifidobacterium longum HY8001 against vero cytotoxin of Escherichia coli O157:H7. Journal of Food Protection, 64(11):1667-1673.
I-3. Chang-Hwan Kim, Beom-Jun Lee, Junghee Yoon, Kang-Moon Seo, Jong-Hwan Park, Jin-Won Lee, Eun-Sil Choi, Jung-Joo Hong, Yong-Soon Lee, and Jae-Hak Park (2001). Therapeutic effect of hyaluronic acid on experimental osteoarthrosis of ovine temporomandibular joint. Journal of Veterinary Medical Science, 63(10):1083-1089.
I-2. Jong-Hwan Park, Beom-Jun Lee, Yong-Soon Lee, and Jae-Hak Park (2000). Association of tightly spiraled bacterial infection and gastritis in pigs. Journal of Veterinary Medical Science, 62(7):725-729.
I-1. Yeonhee Lee, Jinhui Lee, Hyunjoo Cho, Enjoo Shin, Jong-Hwan Park, and Jae-Hak Park (1999). Characterization of Campylobacters newly isolated from swine gastric mucosa. Journal of Microbiology and Biotechnology, 9(6):778-783. Ⅱ. Domestic Journals
D-29. Tae-Hyoun Kim, Dong-Jae Kim, Jae-Hak Park and Jong-Hwan Park (2014) TRIF Deficiency does not Affect Severity of Ovalbumin-induced Airway Inflammation in Mice. Immune Network, 14(5):249-254.
D-28. Young-Ha Kim, Sang-Hoon Lee, Yung-Choon Yoo, Junglim Lee, Jong-Hwan Park and Seok-Rae Park (2012) Kinetic analysis of CpG-induced mouse B cell growth and Ig production. Immune Network, 12(3):89-95.
D-27. Tae-Hyoun Kim, Ju-Hee Han, Seo-Na Chang, Dong-Su Kim, Tamer Said Abdelkader, Seung-Hyeok Seok, Jong-Hwan Park, Hong-Shik Oh, Jong-Taek Kim, Byoung-Hee Lee, Jeong-Hwa Shin, Jung-Hyun Kim, Jong-Min Kim, and Jae-Hak Park (2012) Adiaspiromycosis of an Apodemus agrarius captured wild rodent in Korea. Laboratory Animal Research, 28(1), 67-69.
D-26. Tae-Hyoun Kim, Ju-Hee Han, Seo-Na Chang, Dong-Su Kim, Tamer Said Abdelkader, Seung-Hyeok Seok, Jong-Hwan Park, Hong-Shik Oh, Jong-Taek Kim, Byoung-Hee Lee, Jeong-Hwa Shin, Jung-Hyun Kim, Jong-Min Kim, Jae-Hak Park (2011) Detection of sarcocystic infection in a wild rodent (Apodemus agrarius chejuensis) captured on Jeju island. Laboratory Animal Research, 27(4), 357-359
D-25. Seung-Hyeok Seok, Jong-Hwan Park, Sun-A Cho, and Jae-Hak Park (2005) Idiopathic intranuclear inclusion bodies in the renal tubular epithelia of Japanese quail (Coturnix coturnix japonica). Journal of Veterinary Science, 6(1):75-76.
D-24. Seung-Hyeok Seok, Jong-Hwan Park, Min-Won Baek, Hui-Young Lee, Dong-Jae Kim, and Jae-Hak Park (2004). The acceptance or rejection of syngeneic murine tumor transplantability in C57BL/6 mice. Korean Journal of Laboratory Animal Science, 20(1)109-111.
D-23. Asako Kasuga, Jong-Hwan Park, Seung-Hyeok Seok, Min-Won Baek, Hui-Young Lee, Dong-Jae Kim, and Jae-Hak Park (2004) An atlas of zebrafish (Danio rerio) histology. Korean Journal of Laboratory Animal Science, 20(2)118-127.
D-22. Dong-Jae Kim, Jong-Hwan Park, Seung-Hyeok Seok, Sun-A Cho, Min-Won Baek, Hui-Young Lee, Dong-Deuk Jang, Ki-Hwa Yang, Beom-Seok Han, and Jae-Hak Park (2004) Development of ELISA (Enzyme-linked Immunosorbent Assay) using LAMP of Mycoplasma pulmonis. Korean Journal of Laboratory Animal Science, 20(3)224-228.
D-21. Seung-Hyeok Seok, Jong-Hwan Park, Min-Won Baek, Hui-Young Lee, Dong-Jae Kim, and Jae-Hak Park (2004). Abnormal larvae development of zebrafish eggs fertilized by intracytoplasmic sperm injection. Korean Journal of Laboratory Animal Science, 20(3)229-233.
D-20. (2004) Effect of recombinant human Granulocyte Macrophge-Colony Stimulating Factor on mucous membrane in syrian hamster buccal pouches.
D-19. Sun-A Cho, Jong-Hwan Park, Seung-Hyeok Seok, Hui-Young Lee, Dong-Jae Kim, and Jae-Hak Park (2003). Cancer lesions in C57BL/6 mouse treated with N-nitroso-N-methylurea (MNU) and testosterone propionate. Korean Journal of Laboratory Animal Medicine, 19(2):81-84.
D-18. Jong-Hwan Park, Chang-Hwan Kim, Jung-Joo Hong, and Jae-Hak Park (2003) Experimental infection of pigs with tightly spiral bacteria. Korean Journal of Laboratory Animal Medicine, 19(2):85-89.
D-17. Seung-Hyeok Seok, Jong-Hwan Park, Sun-A Cho, Min-Won Baek, Hui-Young Lee, Dong-Jae Kim, and Jae-Hak Park (2003). Coccidia (Eimeria spp.) in small intestine of Japanese quail (Coturnix coturnix japonica). Korean Journal of Laboratory Animal Medicine, 19(2):90-91.
D-16. Jong-Hwan Park (2003) Effect of probiotic lactic acid bacteria isolated in Korea in cutaneous hypersensitivity rats. Korean Journal of Laboratory Animal Medicine, 19(2):117-119.
D-15. Jong-Hwan Park, Jung-Joo Hong, Eun-Sil Choi, Jin-Won Lee, and Jae-Hak Park (2002) Efficacy of purified Vi polysaccharide typhoid vaccine. Journal of Veterinary Science, 3(2)67-70.
D-14. Jong-Hwan Park, Hee-Myung Park, Seung-Hyeok Seok, Sun-A Cho, Hui-Young Lee, Dong-Jae Kim, and Jae-Hak Park. (2002). Prevalence and pathological characteristics of Helicobacter spp. in gastric mucosa of domestic pet dogs. Korean Journal of Laboratory Animal Science, 18(3):120-124.
D-13. Jong-Hwan Park, Seung-Hyeok Seok, Sun-A, Cho, Heungshik S. Lee, Rho-Hyun Seong, Dae-Hun Park, and Jae-Hak Park. (2002). Study on the microbial infection of mice and rats produced in barrier system. Korean Journal of Laboratory Animal Science, 18(2):90-95.
D-12. Jae-Hak Park, Hak-Mo Lee, Chang-Hwan Kim, and Jong-Hwan Park (2001). Gastric lesions of slaughtered pigs. Korean Journal of Veterinary Pathology, 5(1):17-19.
D-11. Eun-Sil Choi, Jong-Hwan Park, Jung-Joo Hong and Jae-Hak Park (2001). Acute oral toxicity test in Japanese quail. Journal of Toxicology and Public Health, 17(4):287-296.
D-10. Seung-Hyeok Seok, Jong-Hwan Park, Sun-A Cho, Kyung-Chul Choi, and Jae-Hak Park (2001). Comparison of hypercholesterolemia induced by Triton WR-1339 and high cholesterol diet. Korean Journal of Laboratory Animal Medicine, 17(1):7-11.
D-9. Eun-Sil Choi, Hee-Jung Yoon, Chang-Hwan Kim, Jong-Hwan Park, Jin-Won Lee, Jung-Joo Hong, and Jae-Hak Park (2001). Demodicosis in Laboratory Beagle dogs. Korean Journal of Laboratory Animal Medicine, 17(2):129-133.
D-8. Seung-Hyeok Seok, Jong-Hwan Park, Sun-A Cho, Kyong-Yoon Park, and Jae-Hak Park (2001). Report of aspergillosis of a chick in Korea. Korean Journal of Veterinary Pathology, 5(1):21-22. D-7. Jong-Hwan Park, Jung-Joo Hong, Hee-Myung Park, Seung-Hyuk Seok, Sun-A Cho, and Jae-Hak Park (2001) Infection of Helicobacter spp. in gastric mucosa of domestic pet dogs. Korean Journal of Veterinary Pathology 5(1):1-4
D-6. Chang-Hwan Kim, Beom-Jun Lee, Jong-Hwan Park, and Jae-Hak Park (2000). Antitumor effects of recombinant human interferon α-2a and hydroxyurea against chronic myelogenous leukemia. Korean Journal of Veterinary Research, 40(1):166-172.
D-5. Jin-Won Lee, Chang-Hwan Kim, Jong-Hwan Park, Eun-Sil Choi, Jung-Joo Hong, Jae-Sup Park, and Jae-Hak Park (1999). Effect of sodium hyaluronate on osteoarthrosis in rabbit model. The Journal of Applied pharmacology, 7:347-353.
D-4. Jin-Won Lee, Chang-Hwan Kim, Jong-Hwan Park, Eun-Sil Choi, Jung-Joo Hong, and Jae-Hak Park (1999). Acute toxicity test of sodium hyaluronate on Sprague-Dawley rats. Journal of Toxicology and Public Health, 15(4):509-512.
D-3. Byoung-Hee Lee, Young-Jo Kim, Jong-Hyuk Lee, Kyon-Yun Kim, Hyo-Sil Lee, Chang-Hwan Kim, Jong-Hwan Park, Eun-Sil Choi, Joo-Ho Tae, and Jae-Hak Park (1998). Effect of recombinant human growth hormone (rhGH) on the promotion of body weight gain in the hypophysectomized rats. Korean Journal of Laboratory Animal Medicine, 14(1):77-79.
D-2. Jae-Hak Park, Beom-Jun Lee, Chuel-Kyu Kim, Tae-Kyun Park, Jong-Hwan Park, Chang-Hwan Kim, Guang-Xun Li, and Yong-Soon Lee (1998). Pathological examination of stomachs from beagle dogs spontaneously infected with Gastrospirillum sp. Korean Journal of Laboratory Animal Medicine, 14(2):121-126.
D-1. Chang-Hwan Kim, Ju-Ho Tae, Jong-Hwan Park, Sin-Young Kang, Seung-Jin Lee, Dae-Han Park, Byung-Su Kim, and Jae-Hak Park (1998). Antitumor effect of recombinant interferon α-2a in nude mice. Korean Journal of Laboratory Animal Medicine, 14(2):251-255.