CURRICULUM VITAE

Name Sang-Kyou Lee, Ph.D. Present Position Dean College of Life Science and Biotechnology

Professor Department of Biotechnology Yonsei University, Seoul, Korea

Date of Birth October 2, 1957

Place of Birth KwangJu, Korea

Citizenship Korean

Office Address 134 ShinChon-Dong, SeoDaeMun-Gu Dept. of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea, 120-749 Tel: 82-2-2123-2889 Fax: 82-2-362-7265 Email: [email protected]

Marital Status Married

Education 1976-1984 : Dept. of Biotechnology, Yonsei University (B.E.) 1984-1986 : Dept of Immunology, School of Medicine University of Michigan, Ann Arbor (M.S.)

1988-1992 : Section of Immunobiology, Yale Medical School (Ph.D.)

Postgraduate Training 1992 – 1995 : Division of Immunology, Harvard Medical School (Postdoctoral Fellow and Research Associate)

1995 -current : Professor, Dept. of Biotechnology, Yonsei University

2000 - 2011 : CTO, ForHumanTech Co. Ltd.

2009 - 2013 : Director (염증반응제어 창의연구단 단장) National Creative Research Initiatives Inflammatory Response Modulation

2014 - 2016 : Dean, College of Life Science and Biotechnology (연세대학교 생명시스템대학 학장)

2014 – current : Director of National Research Laboratory (NRL) and Global Research Laboratory (GRL)

2016 – current : CEO of Good T Cells, Inc.

Awards 2003: Best Research Award From Yonsei University 2006: Best 50 Research Award From Korea Science and Engineering Foundation

Membership in Professional Societies Member of Korean Immunology Society Member of American Immunology Association

Publications

1) Selected recent Publications

1. Sang-Kyou Lee*, Shaw, A., Maher, S.E. and Bothwell, A.L.M. (First Author) p59fyn tyrosine kinase regulates p56lck tyrosine kinase activity and early TcR-mediated signaling. International Immunology, Vol.11, 1621-1627 (1994), (I.F. = 3.8)

2. Sang-Kyou Lee*, Su,B., Maher, S.E. and Bothwell, A.L.M. (First Author) Ly-6A is required for T cell receptor expression and protein tyrosine kinase fyn activity. EMBO, Vol. 13, 2167-2176 (1994) (I.F. = 15)

3. Tomohiro Morio, Silva H. Hanissian, Leonard B. Bacharier, Hirobumi Teraoka, Shigeaki Nonoyama, Makoto Seki, Jun Kondoh, Hiroyasu Nakano, Sang-Kyou Lee. Ku in the Cytoplasm Associates with CD40 in Human B Cells and Translocates into the Nucleus Following Incubation with IL-4 and Anti-CD40 mAb. Immunity, Vol. 11, 339-348 (1999) (I.F. = 21.5)

4. Jae-Hyuck Shim, Heung-Kyu Lee, Eun-Joo Chang, Wook-Jin Chae, Duck-Jong Han, Morio Tomohiro, Jung-Jin Yang, Alfred Bothwell and Sang-Kyou Lee* (Corresponding Author) Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific Apoptosis Induction. Proc. Natl. Acad. Sci., U.S.A. Vol 99, no. 16, 10617 - 10622 (2002) (I.F. = 10.5)

5. Wook-Jin Chae, Heung-Kyu Lee, Jin-Hwan Han, Sang-Won Kim, Alfred Bothwell, Tomohiro Morio, Jung-Jin Yang and Sang-Kyou Lee*. (Corresponding Author) Qualitatively Differential Regulation of Intracellular Signaling for T cel activation and apoptosis by TCR z chain ITAM and their tyrosine residues. International Immunology. Vol. 16, No. 9, 1225-1236 (2004), (I.F. = 3.8)

6. Wook-Jin Chae, Octavian Henegariu, Alfred Bothwell and Sang-Kyou Lee. (Corresponding Author) Mutant leucine zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc. Natl. Acad. Sci., U.S.A. Vol. 103, No. 25, 9631-9636 (2006) (I.F. = 10.5)

7. Je-Min Choi, Mi-Hyun Ahn, Wook-Jin Chae, Yung-Gook Jung, Byung-fhy Seo, Jae-Chul Park, Kyun-Do Kim, Eun-Sung Kim, Jung-Ah Shin, Hyun- Mi Song, Young-Eun Kim, Tae-Kwann Park, Jung-Hoon Lee, Dong-Ho Lee, Seung-Kyou Lee, Choon-Sik Park and Sang-Kyou Lee. (Corresponding Author) Intra-nasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation and hyper- responsiveness. Nature Medicine, Vol. 12, No. 5, 574-579 (2006) (I.F. = 31.2)

8. Je-Min Choi, Seung-Hyung Kim, Jae-Hoon Shin, Thomas Gibson, Byoung-Seok Yoon, Dong-Ho Lee, Seung-Kyou Lee, Alfred L. M. Bothwell, Jong-Soon Lim, Sang-Kyou Lee. (Corresponding Author) Intracellular delivery of cytoplasmic domain of CTLA-4 inhibits TcR- specific membrane proximal activation signals and prevents collagen- induced arthritis. PNAS, vol. 105, no. 50, 19875-19880 (2008) (I.F. = 9.8)

9. Woo-Chul Chang, So-Yeon Lim, Byeong-Wook Song, Hee-Sang Song, Chi-Young Shim, Dong-Hyuck Ahn, Young-Gook Jung, Dong-Ho Lee, Ki-Doo Choi, Seung-Kyou Lee, Nam-Sik Chung, Sang-Kyou Lee, YangSoo Jang, Ki-Chul Hwang. (Co-corresponding Author) Mesenchymal Stem cells pretreated with transducible Hph-1-Hsp70 protein are protected from hypoxia-mediated cell death and rescue heart functions from myocardial injury. Stem Cells, Vol. 27, no. 9, 2283-2292, (2009) (I.F. = 8.5)

10. Kyun-Do Kim, Je-Min Choi, Wook-Jin Chae and Sang-Kyou Lee (corresponding author) Synergic inhibition of T-cell activation by cell-permeable ZAP-70 mutant and ctCTLA-4 BBRC , Vol. 381, 355-360, (2009)(I.F. = 2.7)

11. Naomi Takahashi, Kenji Matsumoto, Hirohisa Saito, Toshihiro Nanki, Nobuyuki Miyasaka, Tetsuji Kobata, Miyuki Azuma, Sang-Kyou Lee, Shuki Mizutani, and Tomohiro Morio Imparied CD4 and CD8 effector function and decreased memory T-cell populations in ICOS deficient patients. Journal of Immunology, Vol .182, 5515-5527,(2009) (I.F. = 7.5)

12. Eun-Sung Kim, Seung-Woo Yang, Dong-Ki Hong, Woo-Tak Kim, Ho- Guen Kim, Sang-Kyou Lee (Corresponding Author) Cell-penetrating DNA-binding protein as a safe and efficient naked DNA delivery carrier in vitro and in vivo BBRC , Vol. 392, no.1, 9-15,(2009) (I.F. = 2.7)

13. Mi-Sook Lee, Eun-Hye Kwon, Hoon-Sung Choi, Seung-Hae Kwon, Chul- Hyun Lee, In-Sop Shim, Sang-Kyou Lee, Song Her. Quantification of Cellular Uptake and in vivo tracking of trasduction using real-time monitoring. BBRC, Vol .394, no2 ,348-353 (2009) (I.F. = 2.7)

14. Jae-Hyuck Shim, Min-Jung Shin, Jae-Young Lee, Wook-Jin Chae, Heung-Kyu Lee, Tomohiro Morio, Jun Han Park, Eun-Ju Chang*, and Sang-Kyou Lee* (Corresponding author) Qualitatively and quantitatively differential intensity of Fas-mediated intracellular signals determines life and death in T cells. International Journal of Hematology , Vol. 92, no.2, 262- 270,(2010) (I.F.=2.0)

15. Yu-Mee Wee, Monica Young Choi, Choong-Hoon Kang, Yang-Hee Kim, Jen-Hee Kim, Sang-Kyou Lee, Seung-Young Yu, Song-Cheol Kim, and Duck-Jong Han The Synergistic Effect of Tautomycetin on Cyclosporine A-Medicated Immunosuppression in a Rodent Islet Allograft Model. Molecular Medicine, Vol .16, no.7-8, 298-306 (2010) (I.F.=5.02)

16. Je-Min Choi, Jae-Hoon Shin, Myung-Hyun Sohn, Marth J. Harding, Da- Young Kim, Wook-Jin Chae, Sung-Ho Park, Chun-Geun Lee, Sang- Kyou Lee, and Alfred Bothwell (Co-coresponding Author) Cell permeable Foxp3 protein alleviates autoimmune disease associated with IBD and allergic airway inflammation PNAS, vol 107, no 43, 18575-18580(2010) (I.F.=9.8)

17. Do Jin Kim, Kang-Seo Park, Jung-Ho Kim, Sang-Hwa Yang, Ji Young Yoon, Byeong-Gu Han, Hyoun Sook Kim, Sang Jae Lee, Jun Young Jang, Kyoung Hoon Kim, Mi Jung Kim, Jin-Su Song, Hie-Joon Kim, Chung-Mo Park, Sang-Kyou Lee*, Byung Il Lee*, and Se Won Suh* (Co- corresponding author) A Helicobacter pylori Proinflammatory Protein Is a Cell-translocating Ser/Thr Kinase for Up-regulation of NF-κB. PNAS, vol 107, no 50, 21418-21423(2010)(I.F.=9.8)

18. MiiRa Jung, In-Kyong Shim, Eun-Sung Kim, Yoon-Jeong Park, Young-Il Yang, Sang-Kyou Lee, Seung-Jin Lee Controlled release of cell-permeable gene complex from poly(L-lactide) scaffold for enhanced stem cell tissue engineering. Journal of Controlled Release, Vol .152, no.2, 294-302(2011) (I.F.=7.164)

19. K.J., Song, Y.S. Jang, Y.A. Lee, K.A. Kim, S.K. Lee and M.H. Shin Reactive oxygen species-dependent necroptosis in Jurkat T cells induced by pathogenic free-living Naegleria fowleri. Parasite Immunology, vol 33, no.7, 390-400(2011) (I.F.=2.1)

20. Sang-Won Lee, Ji-Hye Kim, Min-Chan Park, Yong-Beom Park, Wook-Jin Chae, Tomohiro Morio, Dong-Ho Lee, Ki-Doo Choi, Joo-Hyung Lee, Dong-Hwan Park, Seung-Kyou Lee, Soo-Kon Lee, Sang-Kyou Lee (Corresponding author) Alleviation of rheumatoid arthritis by cell-transducible methotrexate upon transcutaneous delivery Biomaterials, Vol . 33, no.5, 1563-1572(2012)(I.F.=7.9)

21. Fumiko Honda, Yumiko Hane, Tomoko Toma, Akihiro Yachie, Eun-Sung Kim, Sang-Kyou Lee, Masatoshi Takagi, Shuki Mizutani, and Tomohiro Morio Transducible form of p47phox and p67phox compensate for defective NADPH oxidase activity in neutrophils of patients with chronic granulomatous disease BBRC, Vol. 417, 162-168 (2011) (I.F. = 2.7)

22. Sato R, Iiizumi S, Kim E-S, Honda F, Lee S-K, Adachi N, Koyama H, Mizutani S, Morio T. Impaired cell adhesion, apoptosis, and signaling in WASP-gene disrupted Nalm-6 pre-B cells and recovery of cell adhesion using a transducible form of WASp. Int. J. Hematol. 95:299-310, 2012. (I.F.=2.0)

23. Jae-Hyuck Shim, Matt Greenblatt, Anju Singh, Nicholas Brady, Dorothy Zhang Hu, Rebecca Drapp, Wataru Ogawa, Masato Kasuga, Tetsuo Noda, Sang-Hwa Yang, Sang-Kyou Lee, Vivienne Rebel, Laurie Glimcher Administration of BMP2/7 in utero partially reverses Rubinstein Taybi Syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice. Journal of Clinical Investigation, Vol 122, No. 1, 91-106(2012) (I.F.=15)

24. Fumiko Honda, Hirotsugu Kano, Hirokazu Kanegane, Shigeaki Nonoyama, , Eun-Sung Kim, Sang-Kyou Lee, Masatoshi Takagi, Shuki Miautani and Tomohiro Morio. The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils Nature Immunology, Vol .13, 369-378 (2012) (I.F.=25.7)

25. Je-Min Choi, Jung-Ho Sohn, Tae-Yoon Park, Jung-Won Park, Sang- Kyou Lee (Corresponding author) Cell permeable NFAT inhibitory peptide Sim-2-VIVIT inhibits T cell activation and alleviates allergic airway inflammation and hyper- responsiveness. Immunology Letter, Vol.143, no.2, 170-176 (2012) (I.F. = 2.5)

26. Tae-Yoon Park, Seung-Hyung Kim, Yoon-Chul Shin, Nae-Hyun Lee, Jae-Hyuck Shim, Laurie Glimcher, Eunji Cheong, Won-Ki Kim, Jong- Soon Lim and Sang-Kyou Lee (Corresponding author) Amelioration of Alzheimer-associated neurodegeneration by cell death- induced cytoplasmic delivery of humanin Journal of Controlled Release (2013), 166, 307-315 (I.F.=7.164)

27. Jin Mo Park, Jeong Hwan Je, Wen Hao Wu, Hyun Joong Lee, Sang- Kyou Lee and Min-Geol Lee (Co-corresponding author) Attenuation of contact hepersensitivity by cell-permeable heat shock protein70 in Balb/C mouse model Experimental Dermatology 21, 948-976 (2012)(I.F.=4.2)

28. Tae-Yoon Park, Min-Jung Shin, Sung-Dong Park, and Sang-Kyou Lee (Corresponding author) Alleviation of abnormal synaptic neurotransmitter release by cell- permeable form of the truncated SNAP-25 upon transcutaneous delivery Neuroscience Letter 543, 52-57 (2013)(I.F.= 2.2) 29. Dashlkhumbe Byamba, Do Young Kim, Dae Suk Kim, Hyunjoong Jee, Tae-Gyun Kim, Sang-Kyou Lee, Jin-Ok Baek, Min-Geol Lee Therapeutic effect of cell permeable peptide-conjugated methotrexate on a mouse model of psoriasis induced by imiquimod Journal of dermatological science 69, 7-8 (2013) (I.F.=3.520)

30. Jeong Hwan Je, Do Young Kim, Hyo Jin Roh, Chin Pak, Dong Hyun Kim, Dashlkhumbe Byamba, Hyungjoong Jee, Tae-Gyun Kim, Jin Mo Park, Sang-Kyou Lee, Min-Geol Lee The antioxidative effect of heat-shock protein 70 in dendritic cells Scandinavian Journal of Immunology 78(3), 238-247 (2013) (I.F.=2.199)

31. Dashlkhumbe Byamba, Do Young Kim, Dae Suk Kim, Tae-Gyun Kim, Hyunjoong Jee, Sung Hee Kim, Tae-Yoon Park, Sang-Hwa Yang, Sang- Kyou Lee, Min-Geol Lee (Co-corresponding author) Skin-penetrating methotrexate alleviates imiquimod-induced psoriasiform dermatitis via decreasing IL-17-producing gamma delta T cells Journal of dermatological science 23(7), 492-496 (2014) (I.F.=3.520)

32. Soyeon Lim, Woochul Chang, Min-Ji Cha, Byeong-Wook Song, Onju Ham, Se-Yeon Lee, Chang Youn Lee, Jun-Hee Park, Changkyu Oh, Sang-Kyou Lee, Yangsoo Jang, Ki-Chul Hwang PLCδ1 protein rescues ischemia-reperfused heart by the regulation of calcium homeostasis Molecular Therapy 22(6), 1110-1121 (2014) (I.F.=7.8)

33. Jong-Hyun Park, Ji-Seung Ko, Yoonchul Shin, Jen Young Cho, Han-ah Oh, Alfred M. Bothwell and Sang-Kyou Lee*(Corresponding author) Intranuclear interacotmic inhibition of Foxp3 suppresses functions of Treg cells. BBRC 451 (2014), 1-7 (I.F. = 2.7)

34. Tae-Yoon Park, Seong-Dong Park, Jen-Young Cho, Na-Yeon Kim, Christina Rae-Kyung Lee, Sang-Hwa Yang and Sang-Kyou Lee*(Corresponding author) Transcriptional interactomic inhibition of RORγt suppresses TH17 differentiation and autoimmunity PNAS, vol 111, no.52, 18673-18678, (2014)(I.F.=9.8)

35. Jung-Ho Kim, Jae-Seung Moon, JiSang Yu and Sang-Kyou Lee (Corresponding author) Intracellular cytoplasm-specific delivery of SH3 and SH2 domains of SLAP inhibits TcR-mediated signaling BBRC 460 (2015), 603-608 (I.F. = 2.7)

36. Jung-Hwa Chang, Hye Jin Jung, Hyun-Ji Park, Seung-Woo Cho, Sang-Kyou Lee and Ho Jeong Kwon Cell-permeable mitochondrial ubiquinol-cytochrome C reductase binding protein induces angiogenesis in vitro and in vivo Cancer Letters, 366 (2015), 52-60 (I.F. = 5.621)

37. Sung-Dong Park, So Yeong Cheon, Tae-Yoon Park, Bo-Young Shin, Hyunju Oh, Sankar Ghosh, Bon-Nyeo Koo, and Sang-Kyou Lee Intra-nuclear interactomic inhibition of NF-kB suppresses LPS-induced severe sepsis (Corresponding author) BBRC 464 (2015), 711-717 (I.F.=2.7)

38. Sangho Lim, Won-Ju Kim, Yeon-Ho Kim, Sohee Lee, Ja-Hyun Koo, Jung-Ah Lee1, Heeseok Yoon, Do-Hyun Kim, Hong-Jai Park, Hye-Mi Kim, Hong-Gyun Lee, Ji Yun Kim, Jae-Ung Lee, Jae Hun Shin, Lark Kyun Kim, Junsang Doh, Hongtae Kim, Sang-Kyou Lee, Alfred L.M. Bothwell, Minah Suh & Je-Min Choi dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis Nature Communications (2015), 6-8244: 1=13 (I.F. =11.47)

39. Mi-Jeong Jeon, Yoo-seok Shin, Jae-eun Jung, Ul-won Jung, Jae-hoon Lee, Jae-Seung Moon, IlKoo Kim, Jun-su Shin, Sang-Kyou Lee and Je- seon Song (Co-corresponding author) HIF1A Overexpression Using Cell-penetrating DNA-binding Protein Induces Angiogenesis In Vitro and In Vivo. Molecular and Cell Biochemistry (2017)(I.F.=2.7) 40. 2) Manuscripts in revision or in preparation   1. So Yeong Cheon1,2 , Jeong Min Kim1,2 , Eun Hee Kam1,2, Chun Chang Ho3, Eun Jung Kim1,2, Seungsoo Chung4, Ji-Hyun Jeong4, Sang-Kyou Lee3* and Bon-Nyeo Koo1,2* (Co-corresponding author) Cell penetrating interactomic inhibition of nuclear factor-kappa B in postoperative cognitive dysfunction In progress in Scientific Report (2017)

2. Jae-Seung Moon, Chin Hee Mun, Sang-Won Lee and Sang-Kyou Lee (Co-corresponding author) Intra-nuclear delivery of transcription modulation domain of T-bet improved lupus nephritis in (NZB/NZW) F1 lupus-prone mice In Progress in Kidney International (2017)(I.F.=8.7)

3. Jung-Ho Kim, Ye-Kyung Seong, Jung-Ho Kim Sang-Hwa Yang and Sang-Kyou Lee*(Corresponding author) Attenuation of Th-2-mediated autoimmunity by transcriptional modulation domain of GATA-3 In progress in PNAS (2017)(I.F.= 9.8)

4. Sung-Dong Park, Tae-Yoon Park, ChinHee Mun, Kyu-Hyung Park, Jong-Hyun Park, Jae-Seung Moon, Han-Ah Oh, Sang-Won Lee, and Sang-Kyou Lee (Corresponding author) Microneedle-mediated transdermal delivery of transducible Smad3 via temporal area suppresses neuro-inflammation associated with pathogenic T cell subsets. In progress in Nature Medicine (2017)(I.F.=31)

5. Jae-Seung Moon, Jung-Ho Kim, Jun-Chang Hoo, Jin-Soo Shin and Sang-Kyou Lee (Corresponding author) TregL1, Novel surface marker specific to human Treg cells (In progress in Nature (2017)(I.F.=40)

3) Patents

비고 일련 출원(등록) 출원(등록) 출원(등록) 특허명 (기술이전 번호 국가 일자 번호 여부 등) Biomolecule Transduction Motif 2009년 ( ) 1 일본 등록 4,361,370 추진중 SIM-2-BTM and The 8월 21일 Use Thereof Biomolecule Transduction Motif 2009년 ( ) 2 일본 등록 4,361,371 추진중 MPH-1- BTM and 8월 21일 The Use Thereof

경피전달을 위한 2009년 10- ( ) 3 한국 등록 추진중 약제 조성물 5월 8일 0897915 Biomolecule Transduction Motif 2010년 10- 4 한국(등록) 추진중 SIM-2-BTM and The 8월21일 0978344 Use Thereof Biomolecule Transduction Motif 2010년 10- 5 한국(등록) 추진중 MPH-1- BTM and 8월 20일 0978346 The Use Thereof Biomolecule Transduction Motif 2010년 6 유럽(등록) 1468012 추진중 MPH-1- BTM and 6월 16일 The Use Thereof Biomolecule Transduction Motif 2010년 7 미국(등록) US 7,700,109 B2 추진중 MPH-1- BTM and 4월 20일 The Use Thereof Methods for Fusion 2010년 8 Polypeptide 유럽(등록) 1,942,925 추진중 8월 25일 Delivery into a Cell Methods for Treating Rheumatoid 2010년 9 미국(등록) US 7,723,299 추진중 Arthritis Using a 5월 25일 CTLA-4 Fusion Protein

Biomolecule Transduction Motif 2010년 10 유럽(등록) 1468011 추진중 SIM-2-BTM and The 7월 7일 Use Thereof

Biomolecule Transduction Motif 2010년 11 한국(등록) 10-798346 추진중 SIM-2-BTM and The 8월 20일 Use Thereof

전사인자의 ＤＮＡ

결합 도메인 및 단백

질 운반 도메인을 포 2010년 10-2010- 12 함하는 융합단백질을 한국(출원) 추진중 8월 20일 0080864 가지는 전사인자 억

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인과 단백질 운반

도메인을 융합한 2010년 10-2010- 13 단백질을 이용한 한국(출원) 추진중 12월 10일 0126455 알러지성 천식 치료

용 약학 조성물 및

이를 이용한 치료방

법

조절자 Ｔ 세포에

특이적으로 존재하는 2011년 10-2011- 14 한국(출원) 추진중 새로운 표면단백질 1월 24일 0007022

Ｌｒｉｇ-1의 용도

전사인자의 전사활성

조절도메인 및 단백

질 운반 도메인을 가 2011년 15 PCT국제출원 PCT/KR2011/006158 추진중 지는 융합단백질 및 8월 19일

이를 포함하는 전사

인자 기능억제제

조절자 Ｔ 세포에 특

이적으로 존재하는 2012년 16 PCT국제출원 PCT/KR2012/000532 추진중 새로운 표면단백질 1월 20일

TregL-1의 용도

A Novel Fusion Protein Comprising Transcription Modulation Domain 2015년 17 한국(출원) 10-2015-0142144 추진중 of p65 and Protein 10월 12일 Transduction Domain, and Uses Thereof A Novel Fusion Protein Comprising Transcription Modulation Domain 2016년 18 PCT국제출원 PCT/KR2016/000104 추진중 of p65 and Protein 01월 06일 Transduction Domain, and Uses Thereof A Composition Containing Smad Protein for Treatment of Autoimmune 2016년 19 Diseases, a Fusion 한국(출원) 10-2016-0008782 추진중 01월 25일 Protein Comprising Smad Protein, a Expression Vector and a Method for Preparing the Same A Composition Containing Smad Protein for Treatment of Autoimmune 2016년 20 Diseases, a Fusion PCT국제출원 PCT/KR2016/000958 추진중 01월 28일 Protein Comprising Smad Protein, a Expression Vector and a Method for Preparing the Same