Xiang-qiang Chu

Department of Nuclear Science and Technology Email: [email protected] Graduate School of CAEP Tel: 86-10-56989430 Beijing, China 100193 http://gscaep.ac.cn/english/index.php/divisions/view?id=11

EMPLOYMENTS 2017 – Present Professor, Department of Nuclear Science and Technology, Graduate School of CAEP 2017 – 2018 Associate Professor, Department of Physics and Astronomy, Wayne State University, US 2012 – 2017 Assistant Professor, Department of Physics and Astronomy, Wayne State University, US 2010 – 2012 Postdoctoral Research Associate, Biology and Soft Matter Division, Oak Ridge National Laboratory (ORNL)

EDUCATION 2005 – 2010 Ph.D., Nuclear Science and Engineering, Massachusetts Institute of Technology (MIT) 1998 – 2005 M. S., B. S., Nuclear Physics, Peking University, Beijing, China

RESEARCH INTERESTS Neutron and X-ray Scattering; Protein dynamics; Membrane protein structures; Protein-water interactions; Dynamics of liquids on biological and nano-scale material surfaces

PROFESSIONAL SOCIETY MEMBERSHIPS American Physical Society (APS), Biophysical Society (BPS), Neutron Scattering Society of America (NSSA), American Chemical Society (ACS), American Crystallographic Association (ACA), Chinese Physical Society (CPS), Chinese Association on Small Angle Scattering

SELECTED GRANTS AND AWARDS • National Natural Science Foundation of China (NSFC), General Program, RMB 660,000, 01/01/2019 – 12/31/2022 (PI); • NSF Division of Molecular and Cellular Biosciences (MCB), “Investigation of Protein Dynamics on Multiple Timescales by Neutron Scattering and Molecular Dynamics Simulations”, $428,271, 07/01/2016 – 06/30/2019 (PI); • Successful Research Proposals as Principal Investigator, 2012 – 2019 (Overall instrument time estimated worth over $3,000,000): ➢ 26 days of beam-time at ISIS, UK ➢ 37 days of beam-time at Australian Centre for Neutron Scattering (ACNS), ANSTO ➢ 59 days of beam-time at Spallation Neutron Source, Oak Ridge National Lab (ORNL); ➢ 48 days of beam-time at NIST Center for Neutron Research; ➢ 19 days of beam-time at Advance Photon Source, Argonne National Lab (ANL); ➢ 6 days of beam-time at Brookhaven National Lab (BNL); ➢ 27 days of beam-time at Institut Laue Langevin (ILL), France. • Richard J. Barber Summer Research Program Grants, Wayne State University (2013, 2014) Xiang-qiang Chu 1/6

• Research Cluster Grant for a High-performance computer cluster from Silicon Mechanics, $190,000 value, 2014 (co-PI); • Biophysical Society CPOW Travel Award, 2015; • ORAU Travel Grants, 2013; • Manson Benedict Fellowship, MIT, 2010

TEACHING AND ADVISING • 2018-2019 Fall, Neutron Scattering Techniques and Applications, GSCAEP; • 2018 Fall, Guest Lecturing at Peking University, CIAE, and Sun Yat-Sen University. • 2016 Fall, PHY 5750, Biological Physics; 2013-2017 Winter: PHY6780, Research Methods in Biomedial Physics; 2015 Fall, 2014 Fall, 2013 Fall: PHY2130, General Physics; 2012 Fall PHY2130, General Physics Quiz Sections; 2015-2017 Guest Lecturing: PSL7215 (NanoBioScience), PHY 6450, PHY6991. • Postdoctoral Advisee: Dr. Debsindhu Bhowmik, Wayne State University, Feb. 2014 – Feb. 2016 • Graduate students at GSCAEP: Jingjing Han, Zhixin Wang, Xudong Gu,Xiang Luo • Graduate students at WSU: Gurpreet Dhindsa (Ph.D. in 2015), Utsab Shrestha (Rumble Fellowship, 2015-2016; Ph.D. in 2017), Kavindya Senanayake, Gobin Acharya, Kurt William Van Delinder (M.S. in 2014), Mohamad Bazzi (Bioengineering); Undergraduate students: Rifat Sattar, Nicholas Faucher, Andrew Rusek, Resiola Neli (Chemistry), Everett Hall (Chemistry), Eric Darnell, Joshua Jacob Kovoor

SCHOLARLY AND PROFESSIONAL ACTIVITIES • Referee for Nature Communications, the Journal of Physical Chemistry Letters, Biopolymers, BBA-Biomembranes, Chemical Physics, PLOS One, Computational and Structural Biotechnology Journal, Frontiers of Physics, Chemical Science, Journal of Physical Chemistry B, Physica B • Editorial Board Member: Scientific Reports, Nature Publishing Group • Organizer, Summer School on Neutron Scattering, CMRR, Mianyang, July 2019 • Co-organizer, Neutron Workshop on Biological and Soft Matter Science, Shanghai, May 2019 • Co-organizer, Spring School of SSLab: Protein dynamics and structure, Feb. 2019 • Organizer, 1st National Workshop on Deuteration Technology for Neutron Scattering, June 2018 • Organizing committee and session chair, ACNS 2018. • Session chair, ICCBM 17, Shanghai, 2018. • Panelist, NSF DMCB, Biophysics program, March 2018. • Reviewer, ANSTO Neutron Sciences Proposals, 2019-2020. • Reviewer, CSNS Neutron Sciences Proposals, 2018-2019. • Reviewer, ORNL Neutron Sciences Proposals, 2018-2019. • Local Organizing Committee member of Conference for undergraduate women in Physics (CUWiP) 2017 • Co-organizer and chair for an invited session at the APS March Meeting 2014 • Reviewer, NSF DMCB, Biophysics program, 2017 • Reviewer, the DOE SCGSR program, May 2015

Xiang-qiang Chu 2/6

SELECTED PRESENTATIONS AND INVITED TALKS 1. Keynote Talk at 3rd Asia-Oceania Conference on Neutron Scattering (AOCNS), Taiwan, Nov. 2019. 2. Invited Talk at Center for Applied Physics and Technology, Peking University, Sep. 2019. 3. Invited Talk at 1st Conference on Small Angle Scattering, Mianyang, China, Sep. 2019. 4. Invited Talk at Australian Centre for Neutron Scattering (ACNS), ANSTO, Australia, June 26, 2019. 5. Invited Talk at Forum on Multiscale Protein Structure and Dynamics, National Facility for Protein Science, Shanghai, May 24, 2019. 6. Invited Talk at Neutron Workshop on Biological and Soft Matter Science, Shanghai, May 13, 2019. 7. Talk at GRC on Neutron Scattering, Hong Kong, May 8, 2019. 8. Invited Talk at SANS user meeting,CSNS, Dongguan, April 8, 2019 9. Invited Talk at Department of Engineering Physics, Tsinghua University, Jan. 17, 2019. 10. Invited Talk at Forum on Small Angle Scattering, Changchun, Jan. 14, 2019. 11. Invited Talk at Workshop on Protein Structure, Dynamics and Functions, CSRC, December 12, 2018. 12. Invited Talk at Sun Yat-Sen University, Guangzhou, November 1, 2018. 13. Invited Talk at Beijing University of Posts and Telecommunications (BUPT), October 29, 2018. 14. Plenary Talk at the 6th National Conference on Neutron Scattering & Workshop on Applications of National Neutron Facilities, Shanghai, China Oct. 15, 2018. 15. Invited Talk at Department of Physics, Beijing Institute of Technology (BIT), September 1, 2018. 16. Keynote Talk at QENS/WINS2018, Hong Kong, July 16, 2018. 17. Invited Talk at 2nd symposium of Research Reactor Applications, Chengdu, May 8, 2018. 18. Invited Talks at 6th Lecture Tour by Chinese Female Physicists (Nanchang University, Jiangxi Normal University, Jiujiang College, Jinggangshan University, Gannan Normal University), Jiangxi, April 24-27, 2018. 19. Invited Talk at Department of Physics, Renmin University, Beijing, April 4, 2018. 20. Invited Talk at 1st Forum on Deep-sea and Deep-space Research, Sanya, March 23, 2018. 21. Invited Talk at Centural Michigan University, Mt Pleasant, MI, Feb. 27, 2018. 22. Invited Talk at School of Physics, Suzhou University, Suzhou, China, Feb. 5, 2018. 23. Invited Talk at Center for Protein Research, Shanghai, China, Feb. 1, 2018. 24. Invited Talk at Donghua University, Shanghai, Jan. 31, 2018 25. Invited Talk at Department of Physics, Fudan University, Shanghai, Jan. 30, 2018 26. Invited Talk at IOP, CAS, Beijing, Jan. 5, 2018 27. Invited Talk at Department of Physics, Nanjing Agricultural University, Nanjing, Jan. 3, 2018. 28. Invited Talk at Kunming University of Science and Technology, Kunming, Dec. 21, 2017. 29. Invited Talk at South University of Science and Technology, Shenzhen, Dec. 19, 2017. 30. Invited Talk at CSNS, Dongguan, Dec. 18, 2017. 31. Invited Talk at the 3rd Forum on Computational Material Sciences and Computational Chemistry, CSRC, Beijing, China, Dec. 2017. 32. Plenary Talk at the 5th National Conference on Neutron Scattering & Workshop on Applications of National Neutron Facilities, Chengdu, China Nov. 1, 2017. 33. Invited Talk at Chinese Physical Society (CPS) Fall meeting, Chengdu, China Sep. 8, 2017. 34. Invited Talk at CAEP Institute of Nuclear Physics and Chemistry Annual Meeting, Chengdu, China Aug. 22, 2017. 35. Invited Talk at American Conference on Neutron Scattering (ACNS), Long Beach, CA, July 2016. 36. Invited Talk at iHuman Institute, ShanghaiTech University, Shanghai, China, May 2016. Xiang-qiang Chu 3/6

37. Invited Talk at College of Chemistry and Molecular Engineering, Peking University, Beijing, China, May 2016. 38. Invited Talk at School of Physics, Wuhan University, Wuhan, China, May 2016. 39. Invited Talk at China Institute of Atomic Energy, Beijing, China, May 2016. 40. Invited Talk at Institute of Physics, Chinese Academy of Sciences, Beijing, China, May 2016. 41. Invited Talk at School of Physics, Nanjing University, China, Apr. 2016. 42. Invited Talk at Frontiers in Structural Biology of Membrane Protein & Pittsburgh Diffraction Conference, Huntsville, AL, Mar. 2016. 43. Invited Talk at Institute for Bioscience and Biotechnology Research, Rockville, MD, Feb. 2016. 44. Invited Talk at Institute of Marine and Environmental Technology, Baltimore, MD, Jan. 2016. 45. Invited Talk at College of Engineering and Applied Sciences, Nanjing University, China, Dec. 2015. 46. Invited Talk at School of Physics, Huazhong University of Science and Technology, Dec. 2015. 47. Invited Talk at School of Medicine, Wayne State University, Detroit, MI, Dec. 2015. 48. Invited Talk at the SNS/HFIR User Meeting, Oak Ridge National Laboratory, TN, Oct. 26, 2015. 49. Invited Talk at International Workshop on the Structure and Dynamics of Supercooled Water and Other Glassy Materials, Palermo, Italy, Oct. 13, 2015. 50. Invited Talk at Department of Physics, Shanghai Jiaotong University, Shanghai, China, June, 2015. 51. Invited Talk at the APS (American Physical Society) March Meeting, Denver, CO, Mar. 6, 2014. 52. Contributed talk at the APS March Meeting, Denver, CO, Mar. 5, 2014. 53. Talk at Biophysical Society (BPS) 58th Annual Meeting, San Francisco, CA, Feb. 17, 2014. 54. Invited talk at Department of Physics and Material Science, Hong Kong City University, Hong Kong, China, June 16, 2014. 55. Invited talk at Department of Physics, Tsinghua University, Beijing, China, June 19, 2014. 56. Invited talk at the International Center for Quantum Materials (ICQM), Peking University, Beijing, China, June 18, 2014. 57. Invited talk at the Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, China, June 30, 2014. 58. Invited talk at Medical School, Yangzhou University, Yangzhou, China, July 2, 2014. 59. Invited talk at Department of Physics, Binghamton University, Binghamton, NY, Oct 21, 2013. 60. Invited talk at Department of Physics, Oakland University, Rochester, MI, Sep 26, 2013. 61. Invited talk at Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL, Aug 14, 2013. 62. Plenary talk at the 8th Annual Midwest Conference on Protein Folding, Assembly and Molecular Motions, University of Notre Dame, Notre Dame IN, May 4, 2013. 63. Contributed talk at the APS March Meeting, Baltimore, MD, Mar. 18-22, 2013. 64. Invited talk at Department of Chemistry, Wayne State University, Detroit, MI, Jan 25, 2013. 65. Plenary talk at the 6th Annual WSU Undergraduate Physics Research Conference, Wayne State University, Nov. 16, 2012. 66. Talk at the ACA (American Crystallographic Association) Meeting 2012, Boston, MA, Jul. 31, 2012. 67. Talk at American Conference on Neutron Scattering (ACNS) 2012, Washington, DC, Jun. 27, 2012. 68. Talk at the 243rd ACS (American Chemical Society) National Meeting, San Diego CA, Mar. 26, 2012. 69. Talk at the APS (American Physical Society) March Meeting 2012, Boston, MA, Feb. 29, 2012. 70. Invited talk at Physics Dept. Colloquium, Wayne State University, Detroit, MI, Feb. 16, 2012. 71. Invited talk at Department of Physics, Boston University, Boston, MA, May 27, 2010.

Xiang-qiang Chu 4/6

72. Invited talk at Department of Engineering Physics, Tsinghua University, Beijing, China, Apr. 2009. 73. Invited talk at Department of Mechanical Engineering, Boston University, Boston, MA, Oct. 2008.

SELECTED PUBLICATIONS (*Corresponding Author) (Total publications = 33, total citations = 756, h-index = 14) 1. Jing-Jing Han, Xiang-Qiang CHU*, Using neutron scattering to explore the mysteries in biophysical sciences. Physics, 2019, 48(12): 780-789. 2. R. Ashkar, H. Bilheux, H. Bordallo, R. Briber, D. Callaway, X. Cheng, X.-Q. Chu, J. Curtis, M. Dadmun, P. Fenimore et al., “Neutron scattering in the biological sciences: progress and prospects”, Acta Crystallographica Section D: Structural Biology 74 (12), 1129-1168 (2018). (Lead Article) 3. S. MDC Perera, U. Chawla, U. R Shrestha, D. Bhowmik, A. V. Struts, S. Qian, X.-Q. Chu*, M. F Brown, “Small-Angle Neutron Scattering Reveals Energy Landscape for Rhodopsin Photoactivation”, J. Phys. Chem. Lett. 9, 7064-7071 (2018). 4. U. R Shrestha, D. Bhowmik, K. W. Van Delinder, E. Mamontov, H. M. O'Neill, Q. Zhang, A. Alatas, and X.-Q. Chu*, “Collective Excitations in Protein as a Measure of Balance Between Its Softness and Rigidity”, J. Phys. Chem. B, 121, 923-930 (2017). 5. U. R Shrestha, S. MDC Perera, D. Bhowmik, U. Chawla, E. Mamontov, M. F Brown, X.-Q. Chu*, “Quasi-elastic neutron scattering reveals ligand-induced protein dynamics of a G-protein-coupled receptor”, J. Phys. Chem. Lett. 7, 4130-4136 (2016). 6. G.K. Dhindsa, D. Bhowmik, M. Goswami, H.M. O'Neill, E. Mamontov, B.G. Sumpter, L. Hong, P. Ganesh, and X.-Q. Chu*, “Enhanced Dynamics of Hydrated tRNA on Nanodiamond Surfaces: A Combined Neutron Scattering and MD Simulation Study”, J. Phys. Chem. B, 120, 10059 (2016). 7. U. R. Shrestha, D. Bhowmik, J. R. D. Copley, M.S. Tyagi, J. B. Leão, and X.-Q. Chu*, “The Effects of Pressure on the Dynamics of an Oligomeric Protein from Deep-sea Hyperthermophile”, Proc. Natl. Acad. Sci. U.S.A.(PNAS), 112 (45) 13886-13891 (2015). 8. G. Dhindsa, M. S. Tyagi, and X.-Q. Chu*, “Temperature-dependent Dynamics of Dry and Hydrated β-Casein Studied by Quasielastic Neutron Scattering”, J. Phys. Chem. B 118, 10821-10829 (2014). 9. X.-Q. Chu*, E. Mamontov, H. O’Neill, and Q. Zhang, “Temperature Dependence of Logarithmic-like Relaxational Dynamics of Hydrated tRNA”, J. Phys. Chem. Lett. 4, 936-942 (2013). 10. X.-Q. Chu, M. Gajapathy, K. L. Weiss, E. Mamontov, J. D. Ng and L. Coates, “Dynamic behavior of oligomeric inorganic pyrophosphatase explored by quasielastic neutron scattering”, J. Phys. Chem. B 116, 9917-9921 (2012). 11. E. Mamontov and X.-Q. Chu, “New opportunities for probing protein dynamics in aqueous solutions at low to physiological temperatures”, Physical Chemistry Chemical Physics 14, 11573 (2012). (Perspective Article) 12. X.-Q. Chu, E. Mamontov, H. O’Neill, and Q. Zhang, “Apparent decoupling of the dynamics of a protein from the dynamics of its aqueous solvent”, J. Phys. Chem. Lett. 3, 380-385 (2012). 13. X.-Q. Chu, G. Ehlers, E. Mamontov, A. Podlesnyak, W. Wang, and D. J. Wesolowski, “Diffusion Processes in Water on Oxide Surfaces: Quasielastic Neutron Scattering Study of Hydration Water in Xiang-qiang Chu 5/6

Rutile Nano-Powder”, Phys. Rev. E 84, 031505 (2011). 14. M. Li, X.-Q. Chu, E. Fratini, P. Baglioni, A. Alatas, E. Alp, and S.-H. Chen, “Phonon-like Excitation in Secondary and Tertiary Structure of Hydrated Protein Powders”, a Communication in Soft Matter 7, 9848-9853 (2011). 15. X.-Q. Chu, K.-H. Liu, M. S. Tyagi, C.-Y. Mou, and S.-H. Chen, “Low Temperature Dynamics of Water Confined in a Hydrophobic Mesoporous Material”, Phys. Rev. E 82, 020501 (2010). (Rapid Communication) 16. X.-Q. Chu, M. Lagi, E. Mamontov, E. Fratini, P. Baglioni, and S.-H. Chen, “Experimental Evidence of Logarithmic Relaxation in Single-particle Dynamics of Hydrated Protein Molecules”, Soft Matter 6, 2623-2627 (2010). (Communication) 17. S.-H. Chen, M. Lagi, X.-Q. Chu, Y. Zhang, C. Kim, A. Faraone, E. Fratini, and P. Baglioni, “Dynamics of a globular protein and its hydration water studied by neutron scattering and MD simulations”, a Feature Article in Spectroscopy: Biomedical Applications 24, 1-24 (2010). 18. S.-H. Chen, Y. Zhang, M. Lagi, X.-Q. Chu, L. Liu, A. Faraone, E. Fratini, and P. Baglioni, “The

Dynamic Response Function T (Q,t) of Confined Supercooled Water and its Relation to the Dynamic Crossover Phenomenon”, Z. Phys. Chem. 224, 109-131(2010). 19. X.-Q. Chu, A. Faraone, C. Kim, E. Fratini, P. Baglioni, J. B. Leao, and S.-H. Chen, “Proteins Remain Soft at Lower Temperatures under Pressure”, a Letter in J. Phys. Chem. B 113, 5001 (2009). 20. G. Franzese, K. Stokely, X.-Q. Chu, P. Kumar, M. G. Mazza, S.-H. Chen and H. E. Stanley, “Pressure effects in supercooled water: comparison between a 2D model of water and experiments for surface water on a protein”, J. Phys.: Condens. Matter 20, 494210 (2008). 21. D. Liu, X.-Q. Chu, M. Lagi, Y. Zhang, E. Fratini, P. Baglioni, A. Alatas, A. Said, E. Alp, and S.-H. Chen, “Studies of Phonon-like Low Energy Excitations of Protein Molecules by Inelastic X-ray Scattering”, Phys. Rev. Lett. 101, 135501 (2008). 22. M. Lagi, X.-Q. Chu, C. Kim, F. Mallamace, P. Baglioni and S.-H. Chen, “The Low-Temperature Dynamic Crossover Phenomenon in Protein Hydration Water: Simulations vs Experiments”, J. Phys. Chem. B, 112, 1571 (2008). 23. X.-Q. Chu, E. Fratini, P. Baglioni, A. Faraone, and S.-H. Chen, “Observation of a Dynamic Crossover in RNA Hydration Water which Triggers the Dynamic Transition in the Biopolymer”, Phys. Rev. E 77, 011908 (2008). 24. X.-Q. Chu, A. I. Kolesnikov, A. P. Moravsky, V. Garcia-Sakai, and S.-H. Chen, “Observation of a Dynamic Crossover in Water Confined in Double-Wall Carbon Nanotubes”, Phys. Rev. E 76, 021505 (2007). 25. S.-H. Chen, L. Liu, X.-Q. Chu, Y. Zhang, E. Fratini, P. Baglioni, A. Faraone, and E. Mamontov, “Experimental Evidence of Fragile-to-Strong Dynamic Crossover in DNA Hydration Water”, J. Chem. Phys. 125, 171103 (2006).

Xiang-qiang Chu 6/6