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Endocrine Conditions Endocrine Conditions: Treatment Protocols and Clinical Pearls This document has been prepared by the AOR medical advisory team and peer reviewed by the following clinicians. Authors: Robyn Murphy, ND, BSc Paul Hrkal, ND, BKin Peer review group: Carrie Jones, ND, MPH Aaron Zadek, ND, BSc Sarah Zadek, ND, BSc Jennifer Marion, ND Nirat Nibber, ND Leigh Arseneau, NDHSc, FMP Shari Caplan, MD, CCFP, FCFP, FAARM This document is property of Advanced Orthomolecular Research (AOR) Inc. All rights reserved 2020. It may not be copied, duplicated or reproduced without express written permission from AOR. Disclaimer: For clinical reference only – NOT for public use. The information in this document is for educational purposes only and has not been evaluated by the Natural and Non-prescription Health Product Directorate of Canada (NNHPD) or the FDA. The information and products mentioned are not intended to diagnose, treat, cure, mitigate or prevent any medical condition. The doses are suggestions based on the clinical experience and it is up to the practitioner to apply the information for their patients. Please refer to label for safety data, cautions and interactions. p. 2 Table of Contents General Foundational Protocol for 4 Advanced B Complex® 41 All Chronic Disease Conditions Advanced PCOS Relief 42 Anxiety / Excess Sympathetic 5 Antioxidant Synergy 43 Nervous System (SNS) tone Cogni-Q 44 Insomnia 7 Fem Adapt 45 Estrogen Dominance 9 (Associated conditions: Fibroids, Glycine 46 Endometriosis, PMS, Fibrocystic Breasts) Inositol 47 Menopausal Symptoms 11 L-Carnitine 48 Infertility 13 Magnesium Synergy 49 PCOS 15 Ortho Core® 50 Hypothyroidism 17 Pantethine 52 Hypothalamic-Pituitary-Adrenal Axis 19 Probiotic-3 53 (HPA) Dysfunction Prostate Support 54 Pro 5 HTP 100 22 SoluFibre 55 Pro Adapt 23 Pro Adrenal Glandular 24 Pro B-Complex 25 Pro Bioflavonoids 26 Pro Cortisol Calm 27 Pro Curcumin 28 Pro Destress 29 Pro DysbioX 30 Pro Estro Support 31 Pro GI Repair 32 Pro Lipoic Acid 33 Pro Magnesium Plus 34 Pro Phase Detox II 35 Pro Sleep 36 Pro Thyroid 37 Pro Tri B12 38 Pro Vitamin C 39 Pro Vitex 40 p. 3 General Foundational Protocol for All Chronic Disease Conditions Note: These protocols assume the practitioner has a working understanding of pathophysiology and functional medicine. The following protocols do not include foundational interventions such as omega 3 fatty acids, vitamin D, digestive enzymes, probiotics, etc. Any chronic digestive complaint stresses the need for cellular regeneration and thus, methylation processes. Methylation is also involved in detoxification, immunity, hormone balance and mood. TIME NAME MECHANISM(S) OF ACTION DOSE One to two scoops twice Week Provides minerals for methylation processes, Magnesium daily with or without food; one to balances pH, enhances cellular and Synergy mixes well with lemon water four mitochondrial function in morning Complete combination of highly bioavailable Week and active forms of B vitamins for reduction One to three capsules once two to PRO B Complex of homocysteine to improve methylation, daily with food four metabolism and excretion of hormones Genetic Insight: Use caution with methylcobalamin in those with anxiety and slow COMT activity. May increase catecholamine conversion and epinephrine concentrations leading to accumulation. Consider combination of hydroxycobalaminand adenosylcobalamin forms found in PRO Tri B12 and Advanced B Complex® Ultra. p. 4 Anxiety / Excess Sympathetic Nervous System (SNS) tone *Typical duration/Patient response TIME NAME MECHANISM(S) OF ACTION DOSE One capsule two to three Contains L-theanine, GABA and holy basil to One to times daily – once anxiety increase -waves, modulate catecholamines, three PRO Destress α and excess SNS are stable, glucocorticoids, and blood glucose to reduce months use as needed on an anxiety and stress empty stomach Lowers and balances elevated cortisol and One to catecholamine levels. Targets the entire HPA Two capsules twice daily, three PRO Cortisol Calm axis. Contains phosphatidylserine, Relora®, ideally without food for months ashwagandha, bacopa, theanine, curcumin optimal absorption and cordyceps Magnesium is a calming mineral. Formula One to Two capsules in the PRO contains 50% Mg-glycinate that acts as an three morning and two capsules in Magnesium Plus inhibitory neurotransmitter to calm SNS and 50% months the evening Mg-malate to support mitochondrial function. OPTIONAL CONSIDERATIONS One to Glycine acts as an inhibitory neurotransmitter three Glycine (AOR) One tbsp. PRN to calm SNS. Rapid and acute anxiolytic effect. months Provides key cofactors for healthy adrenal and One to PRO Adrenal HPA function. Clinical feedback has shown One capsule two to three three Glandular it can reduce anxiety despite usually being times daily with food months considered only for adrenal exhaustion.* p. 5 Clinical Pearls: • Glucose control is essential in neurotransmitter and hypothalamus-pituitary- adrenal axis (HPA) modulation. Dysglycemia (poor diet, insulin resistance and cortisol dysregulation) can contribute to anxiety. PRO Destress (holy basil) addresses both dysglycemia and the HPA axis. Also, consider PRO Lipoic Acid. • Vitamin C in high doses supports dopamine elimination and protects neurons from excess NMDA stimulation in those with glutamate excess. Two grams two to three times a day. Use PRO Vitamin C (1,000 mg/capsule) or PRO Bioflavonoids (900 mg/capsule). • Rule out depression, hyperthyroid activity, COPD, asthma, heart disease, chronic pain, IBS or drug withdrawal, which may present with anxiety symptoms. • Progesterone deficiency (and subsequent estrogen dominance) can contribute to ongoing anxiety. Use PRO Vitex to support endogenous progesterone balance. • High levels of persistent catecholamines decrease serotonin levels (decreased gut production). Consider PRO 5-HTP 100 as a precursor to serotonin. ◦ Beware of interaction with SSRIs due to risk of serotonin syndrome. ◦ 5-HTP is less effective at decreasing anxiety when P.M. cortisol is elevated. • Consider PRO Adrenal Glandular over PRO Adapt in cases of pregnancy, postpartum, hypertension, very sensitive patients and pharmaceutical interactions with the herbs found in PRO Adapt (SSRIs, antianxiety medications). Genetic Insight: • Those with slow COMT or MAO activity are prone to accumulation of catecholamines and subsequent anxiety or difficulty calming down after irritation. Support with vitamin C, magnesium and methylation (See chronic disease protocol). In vitro studies show that berberine, rhodiola and curcumin may inhibit MAO; while green tea (EGCG) may inhibit COMT. • Those with S version of the serotonin reuptake transporter (SERT) have an increased sensitivity to stress stimuli, leading to increased Corticotropin-releasing hormone (CRH) levels. p. 6 Insomnia TIME NAME MECHANISM(S) OF ACTION DOSE Contains L-theanine, GABA and holy One to two capsules as needed, up One to basil to increase α-waves, modulate to six capsules daily. One to two three PRO Destress catecholamines, glucocorticoids, and capsules can be used if patient months blood glucose to reduce anxiety wakes in the middle of the night. and insomnia Ideally, take on an empty stomach. Lowers and balances elevated cortisol and catecholamine levels. One to Two capsules after dinner and two PRO Targets the entire HPA axis. Contains three capsules before bed with or Cortisol Calm phosphatidylserine, Relora®, months without food ashwagandha, bacopa, theanine, curcumin and cordyceps Regulates and supports healthy One to PRO Adrenal circadian rhythm and HPA axis function One capsule one to two times daily three Glandular / during the day while PRO Sleep and PRO in the morning with or without food months PRO Adapt Destress acts to calm hormones and neurotransmitters at night Contains theanine, melatonin and 5-HTP, One to to help initiate and maintain sleep. In vitro One to two capsules at bedtime on three PRO Sleep studies demonstrate an increase in GABA an empty stomach months levels using lemon balm and valerian extracts OPTIONAL CONSIDERATIONS One For concomitant mood disorders, 50 mg One capsule two to three times PRO 5-HTP 100 month to 300 mg before bed is indicated. daily, one hour after eating Glycine acts as an inhibitory One to neurotransmitter to calm SNS and has three Glycine (AOR) been shown to increase growth hormone One tbsp. at night months (GH) to encourage repair and regulate hypothalamic-pituitary function. p. 7 Clinical Pearls: • Consider chronic underlying infections (viral, bacterial, fungal or parasitic) with maintenance insomnia. During Th1 driven immune responses, inflammatory cytokines (IFN-γ) may divert tryptophan conversion from serotonin to quinolinic acid. ◦ To support serotonin/melatonin production give niacinamide (B3), (inositol 500 mg to 1,000 mg) and 5-HTP; reduce cognitive inflammation with PRO Curcumin and address possible infection. PRO Cortisol Calm also contains a brain-available form of curcumin (CurQfen). ◦ Note: phthalates and excess cortisol may also lead to high quinolinic acid. • Chronic pain and alcohol use are two of the most common reasons for sleep disturbances. • Changing hormones in perimenopausal/menopausal women are a common cause of insomnia. See estrogen dominance and menopausal sections below. • Remember to address the entire circadian rhythm including the daytime. Get daily natural light exposure especially between 10:00 a.m. and 1:00 p.m. PRO Adapt should be considered in cases of chronic insomnia. Better rhythms in the day will translate
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