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MMP25 Polyclonal Antibody

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MMP25 Polyclonal Antibody MMP25 polyclonal antibody processes, such as embryonic development, reproduction, and tissue remodeling, as well as in Catalog Number: PAB4790 disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which Regulatory Status: For research use only (RUO) are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member Product Description: Rabbit polyclonal antibody raised of the membrane-type MMP (MT-MMP) subfamily, against synthetic peptide of MMP25. attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to Immunogen: A synthetic peptide (conjugated with KLH) bacterial infection or inflammation, the encoded protein corresponding to C-terminus of human MMP25. is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes Host: Rabbit released by activated neutrophils, facilitating the Reactivity: Human,Mouse transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor Applications: ELISA, WB invasion and metastasis through activation of MMP2. (See our web site product page for detailed applications The gene has previously been referred to as MMP20 but information) has been renamed MMP25. [provided by RefSeq] Protocols: See our web site at References: http://www.abnova.com/support/protocols.asp or product 1. Clusterin, an abundant serum factor, is a possible page for detailed protocols negative regulator of MT6-MMP/MMP-25 produced by neutrophils. Matsuda A, Itoh Y, Koshikawa N, Akizawa Form: Liquid T, Yana I, Seiki M. J Biol Chem. 2003 Sep 19;278(38):36350-7. Epub 2003 Jul 14. Purification: Protein G purification 2. Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain Recommend Usage: ELISA (1:1000) tumors. Velasco G, Cal S, Merlos-Suarez A, Ferrando Western Blot (1:100-500) AA, Alvarez S, Nakano A, Arribas J, Lopez-Otin C. Flow cytometry (1:10-50) Cancer Res. 2000 Feb 15;60(4):877-82. The optimal working dilution should be determined by 3. Matrix metalloproteinases. Nagase H, Woessner JF the end user. Jr. J Biol Chem. 1999 Jul 30;274(31):21491-4. Storage Buffer: In PBS (0.09% sodium azide) Storage Instruction: Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing. Entrez GeneID: 64386 Gene Symbol: MMP25 Gene Alias: MMP20, MMP20A, MMPL1, MT-MMP6, MT6-MMP Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological Page 1/1 Powered by TCPDF (www.tcpdf.org).
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