Healthcare New Frontier a Challenge from Kanagawa, Japan Message from the Governor

Healthcare New Frontier A Challenge from Kanagawa, Japan Message from the Governor

In order to create a brighter future vision for the era of the super-aged society, Kanagawa, the second most populous prefecture in Japan adjacent to Tokyo, has been promoting a grand policy package called “Healthcare New Frontier (HCNF).” HCNF is a bundle of healthcare and industrial/regional policies. Its key concept is “Managing ME-BYO,” the scope of which is something broader than that of “disease prevention” in the context of Western medicine. Combining this concept with the utilization of advanced medical treatments and technologies, we aim to achieve healthy longevity of the citizens and to create new markets and industries at the same time. I would greatly appreciate your understanding and support in fulﬁlling our goals. HCNF will provide a solid base for everybody to lead a better life in the coming years.

Yuji Kuroiwa Governor, Kanagawa Prefecture

Healthcare Kanagawa Prefecture has developed “Healthcare New Frontier Promotion New Frontier Plan” to illustrate speciﬁc programs of Healthcare New Frontier Policy, and how the Prefecture will work with citizens to carry out such programs. Promotion For the realization of the ideal future society which the Prefecture envi- Plan sions, the Plan has set the following goals to be attained by the year 2025.

Main Goal 1 Develop ME-BYO Index and Obtain 800,000 Users of ME-BYO Index Main Goal 2 Targets in Focused Areas •Diabetes patients down to the 220,000 level, 5% decrease from 2014 •Pre-metabolic and metabolic syndrome people down more than 25% from 2008

Main Goal 3 Create New Industries •The size of the ME-BYO and regenerative markets in Kanagawa to reach 250 billion yen

Contact Information http://www.pref.kanagawa.jp/div/0121/ Healthcare New Frontier Promotion Phone +81-45-210-2725 Headquarters Ofﬁce Fax +81-45-210-8865 Policy Bureau E-mail [email protected] Kanagawa Prefectural Government 1 Nihon-odori, Naka-ku, Yokohama, Kanagawa, 231-8588, Japan Three Special Zones Initiative for National Strategic Special Zone Kanagawa Prefecture has three special zones: the National Strategic Special Zone covering Tokyo(Haneda) the entire prefecture, the International Airport Sagami Robotics Industry Spe- cial Zone located along the Kawasaki sta. Sagami Jukan Expressway, and the Keihin Coastal Area Life Yokohama sta. Innovation Comprehensive Spe- Special Zone cial Zone centered around Yoko- for Robotics Industry hama and Kawasaki. (the Sagami Area) By utilizing the three special Special Zone zones and combining the two ap- for Life Science Industry proaches —utilizing advanced (the Greater Yokohama - Kawasaki Area) medical treatments and technologies, and managing ME-BYO— Kanagawa is promoting the National Strategic HCNF Policy to create new busi- Special Zone nesses and innovations. Advantage

1. Location and Population Tokyo 14 million Kawasaki city Adjacent to Tokyo Yokohama city 1.5 million ・ Japan’s population: 126.3million 3.8 million Kanagawa pref. ・ No.2 among 47 prefectures with 9.2 million residents million ・ Comparable to the population of Austria (8.85million) 9.2 and Israel (8.88 million) USA 18.6 trillion China 11.2 trillion 2. Size of Economy GDP: Japan 4.9 trillion ($1=¥108.37) Prefectural GDP of approx.$319.4 billion Hong Kong 320.9 billion $319.4 Kanagawa 319.4 billion ・ Comparable to Hong Kong ($320.9billion) and Israel ($317.7billion) 317.7 billion (Source: FY2016 Kanagawa Prefecture Report on Prefectural Accounts) billion Israel

3. Transportation Tokyo Haneda Airport 30 min about Travel time from Haneda Airport to Yokohama by Rail 23km （HND）・ from Yokohama (14.3mi) To Yokohama Station: approximately 30 minutes to Haneda Airport ・ To Kawasaki Station: approximately 15 minutes Yokohama 4. Corporations 302 Number of Foreign-affiliated Firms: 302 (No.2 after Tokyo) Foreign-affiliated (Source: Toyo Keizai Inc.“Directory of Foreign-owned Companies in Japan 2019” ) Firms 5. Human Resources and R&D 1st rank in Japan Number of Researchers: 63,000 people (No.1 in Japan) for number of ・ Kanagawa has the second most R&D labs and offices in Japan researchers Healthcare New Frontier Policy

Healthcare New Frontier (HCNF) is a package of policies developed by the Kanagawa Prefectural Govern- ment to assist everybody to live a long and healthy life in the face of the severe social changes resulting from the advent of the super-aged society. Super-Aged Society Causing a Rapid Change in Population Structure The advancement of an ageing society is a common concern among industrial- Age 85 ~ 80 ~ 84 ized nations, with Japan experiencing the 1970 75 ~ 79 70 ~ 74 65 ~ 69 60 ~ 64 most rapid progress of an ageing society. 55 ~ 59 50 ~ 54 45 ~ 49 Kanagawa is one of the fastest ageing 40 ~ 44 35 ~ 39 Men30 ~ 34 Women 25 ~ 29 societies in Japan. 20 ~ 24 15 ~ 19 10 ~ 14 5 ~ 9 0 ~ 4 50403020100 0 10 20 30 40 50 Problems Arising from Changes (10K. people) Age in Population Structure 85 ~ 80 ~ 84 75 ~ 79 The current social welfare system with 2050 70 ~ 74 65 ~ 69 60 ~ 64 55 ~ 59 the working generation supporting elderly 50 ~ 54 45 ~ 49 Men 40 ~ 44 Women 35 ~ 39 citizens will not be sustainable with the 30 ~ 34 25 ~ 29 20 ~ 24 15 ~ 19 unprecedented changes in social struc- 10 ~ 14 5 ~ 9 0 ~ 4 ture demonstrated by the change in the 50403020100 0 10 20 30 40 50 population pyramid. Population Pyramid of Kanagawa (10K. people) Based on the national population census

Dual Approaches to Solve the Issue of Population Ageing Kanagawa Prefecture has been promoting the HCNF Policy in order to address the issue of population ageing. The HCNF Policy consists of two approaches: pursuing cutting-edge medical treatments and technologies, and managing ME-BYO. Advanced Medical Technologies Managing ME-BYO

iPS cell research Life supporting robot Personal health record Daily food Exercise habit HAL® Prof. Sankai, through smartphone as medicine University of Tsukuba/CYBERDYNE Inc.

Personalized Medicine Healthier Lifestyles

Healthy Longevity and New Markets / Industries

Mar. 2020 Biomedical Cluster Life Innovation Center in Kanagawa The Center for Regenerative Medicine and Cell Therapy

Kanagawa Life Innovation Center (LIC) was launched in April 2016 for the industrialization of regenerative medicine Yokohama Station and cell therapy, a high-potential technology in the next generation of medical care. Kawasaki Station The Center is located in Tonomachi Area, Kawasaki City, Tonomachi Area where cutting-edge companies and institutes in the life science ﬁeld cluster. Utilizing this locational advantage, the Center accelerates the process from R&D to commercializa- tion of regenerative products to achieve application and industrialization of promising technology seeds in regenera- Promoting cooperation tive medicine and cell The bridge is scheduled to open among various technical seeds therapy. in FY 2020 4F Support for venture businesses International Tokyo International Airport Terminal (Haneda Airport)

3F Laboratory & Office Spaces One of the core projects of the Prefecture is taking place in Tonomachi Area, Kawasaki City, a National Strategic Spe- 2F Laboratory & Office Spaces cial Zone. This area along the Tama River is a Kanagawa’s Well-equipped Facilities and cutting-edge life science cluster, called “King Skyfront,” 1F Cell Culture, Production Convenient Research where various companies and institutes have moved in. In and Processing Environments FY2020 Tonomachi Area will be connected to Tokyo with a -Efficient R&D environment bridge, and enable quick access to Tokyo (Haneda) Interna- -Functional and versatile To all over the world interactive spaces and tional Airport only by fifteen minutes’ walk. from Tokyo (Haneda) International Airport meeting rooms

Industry for School of Health Innovation Healthcare Robotics Healthcare robotics will play an essential role in address- In order to promote Healthcare New Frontier Policy, ing various issues of ageing. This technology is used not only Kanagawa Prefecture established a new master’s degree pro- in medical treatments, but also in support of frail seniors gram in Kanagawa University of Human Services, named and people with disabilities who need daily and long-term School of Health Innovation. care. Robotics also supports healthcare workers who aid such The School provides innovative education including public people. Japan is advanced in this field, and HCNF initiatives health, technology, business, administration and practical are utilizing this strength to build a new system of care and training in healthcare-related fields, and offers a Master of support. Public Health (MPH) degree. The classes are taught in both English and Japanese. Examples of Robotics Use in Kanagawa Center for the Promotion of Care Robot Scheme Purpose Development of human resources that can create innovations in healthcare-related fields

Form of Installation Graduate School of Public Health founded in Kanagawa University of Human Services

Address Tonomachi, Kawasaki City, Kanagawa

Open April 2019

Course Term 2 years

Therapeutic robot, Degree Obtained Master of Public Health PARO Cyborg-type Number of 15 per grade robot, HAL Humanoid robot, PARLO Students Advanced Approach Medical Technologies Europe ・Finland (Oulu)

・Germany(Baden-Württemberg) ・UK Japan has made a number of basic research achievements including Kanagawa, Japan the development of iPS Cells, but practical application of these research ・WHO results is rather slow compared with the West. Asia Kanagawa is promoting measures to turn the results of basic ・Singapore research into practical application such as development of revolution- ・India ary drugs, advanced medical equipment and regenerative medical prod- ・China Kanagawa Prefecture has been working hard to spread its important initiatives on the ucts, while stimulating the growth of the industries in these fields. healthcare fields through overseas collaborations.During the past several years, the dele The objectives for combining Kanagawa’s two approaches are to pro- gates from the Prefecture visited relevant government, academic and other organizations in long people’s healthy longevity, to expand areas for cutting-edge medi- many cities in Europe, Asia and the U.S. Kanagawa has signed MOUs with various nations, cal treatments, and to develop new business models in advanced medi- regions and organizations for collaboration in the field of life science. Through t cal and the ME-BYO fields. efforts, the Prefecture expects to promote and support global business exchanges and opportunities.The Prefecture is also collaborating with WHO, and has been sending its members to the organization on a secondment basis.

Healthcare New Frontier Fund

For early realization of Healthcare New Frontier Scheme Applicants Policy, the Prefecture has established “Healthcare publicly invited and Applicants New Frontier Fund” to enhance creation of the (Limited Partner) selected (General Partner) invited (Limited Partner) Kanagawa Prefecture Capital Medica Ventures Inc. Financial Institutions,etc. industries in the fields of ME-BYO and advanced Distributes Distributes Distributes medicine which have a high growth potential. The Invests & Operates Invest Profits profits & fees profits Fund also supports ventures seeking solutions to social healthcare issues. Healthcare New Frontier Investment Limited Partnership Invests For the first time in the healthcare field, the Pre- fecture has introduced the Social Impact Measure- Supports investment Investment & management returns Medical Nursingcare Healthcare Childcare ment for the purpose of developing the ventures. This leads to the higher enterprise value for investee Healthcare Venture Businesses Farming Food Sports ventures.

RINK RINK (The Regenerative Medicine & Cell Therapy Info Sharing, Business Matching, Business Support, R&D Industrialization Network of Kanagawa) Regenerative and Cell Therapy-related LIC Tenants Tonomachi Area Authorities Companies RINK is a network that has been established to FIRM* promote the utilization and industrialization of *Forum for Solid Collaboration Governmental Innovative LIC(KPG) Organizations regenerative medicine and cell therapy. A variety of Regenerative Medicine organizations, institutions, companies and aca- Financial National & Overseas Institutions, Local Academia demia, mainly located in the Life Innovation Center Organizations VC Authorities (LIC) in Tonomachi Area, Kawasaki City, have joined in RINK to collaborate with each other for creating Accelerating industrialization of regenerative medicine innovation. and cell therapies starting from Tonomachi Area. Approach Managing ME-BYO

Healthy Sick U.S.A. ・Massachusetts Healthy ME-BYO Sick ・ Maryland Kanagawa, Japan Instead of clearly defining people’s physical and mental condition ・Stanford Univ. as being either healthy or sick, under the concept of ME-BYO the physical and mental conditions evolve continuously between healthy and sick states, and ME-BYO applies to all conditions between being Global Strategy “healthy” and “sick.” Kanagawa Prefecture has been working hard to spread its important initiatives on the Hence, in order to stay physically and mentally healthy, it is im- healthcare fields through overseas collaborations.During the past several years, the dele- portant for individuals not to wait until they become sick to take gates from the Prefecture visited relevant government, academic and other organizations in action. Rather, it is important for them to monitor closely their Kanagawa has signed MOUs with various nations, “ME-BYO” condition in daily life and take active steps to maintain regions and organizations for collaboration in the field of life science. Through these and improve their physical and mental conditions. The Prefecture is efforts, the Prefecture expects to promote and support global business exchanges and promoting initiatives to stimulate changes in their health awareness opportunities.The Prefecture is also collaborating with WHO, and has been sending its and behavior patterns. members to the organization on a secondment basis.

Healthcare ICT (Information and Communication Technology)

The Prefecture operates an app named “My ME-BYO Record”(*) and encourages citizens to use it to manage their ME-BYO status. This system collects and stores various health information from citizens through smartphone or other devices. The stored data is utilized not only for management of people’s ME-BYO status, but also for child-rearing support and disaster measures.

*Items to be recorded are: medication and vaccination history, medical checkup results, records of Maternal and Child Health Handbook, number of daily steps, body weight and blood pressure, etc. As of March, 2020 “My ME-BYO Record” app is used by over 1,200,000 people who have agreed to the sharing of data.

Kanagawa ME-BYO Living Lab 【Community / 【】 Occupational field】 Kanagawa Businesses ME-BYO Develop and promote Create opportunities to ME-BYO products & services manage ME-BYO and Living Lab In order to establish updated healthcare social system to over- promote health come the issues of the super-aged society, Kanagawa Prefecture is implementing Kanagawa ME-BYO Living Lab in cooperation with industries, government, academia and citizens to develop the field ME-BYO Industries Living Lab Social System for residents to experience managing the status of ME-BYO Residents Everyday Life participate. through ME-BYO technologies and services in which companies can evaluate and verify their function and effectiveness. The Prefecture coordinates interactions between relevant institutes, sets up test fields and assists in recruiting participants, Behaviors change. thus the demonstration should be performed to develop better Living Lab is a field for residents to experience ME-BYO technologies ME-BYO products and promote implementation. and services before they are introduced into society. Spreading the “ME-BYO” Concept Worldwide In order to spread the "ME-BYO" concept around the world, the Prefecture has registered ME-BYO as an international trademark. It is publicizing the term ME-BYO in overseas exhibitions and other PR activities to raise its international recognition to make it a brand name.

ME-BYO Index, Collaboration with WHO

ME-BYO Index Under the concept of ME-BYO, it is important that people work responsibly to manage their ME-BYO status by changing their behaviors into more healthy ones. To encourage their behavioral change, the Prefec- ture announced the launch of the ME-BYO Index. The ME-BYO Index is a numerical value to indicate where people stand on the gradation scale between being healthy and being sick. The Prefec- ture aims to improve the ME-BYO Index as a global index in the future while obtaining advice from experts around the world including WHO.

ME-BYO Industry

The designation of “ME-BYO Industry” refers to industries that, in addition to the traditional steps for prevention/diagnosis, optimize the condition of the entire mind and body with products and services that lead to “Managing ME-BYO”, thereby creating the “value” of leading healthy lives. These industries will be developed as “Made-in-Kanagawa Industries”. )

Association for Kanagawa Prefecture certiﬁes “ME-BYO Japan”, ME-BYO Industry excellent ME-BYO-related products an exhibition and services as demonstrating the advanced “ME-BYO BRAND” ME-BYO-related products and services

Manufacturing Retail Service

Research, ME-BYO Industry ICT, Data Education Workshop Science Checking fatigue and stress by monitoring Medical, Elderly Care Finance people’s autonomic nervous system

ME-BYO Summit Kanagawa

Kanagawa has been holding an international symposium named ME-BYO Summit in Yokohama and the resort town of Hakone every two years since 2015 by inviting experts from home and abroad to discuss the creation of a sustainable social system based on the ME-BYO concept. The results were publicized widely to the world.