Biochemistry Seminars 2004
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Health Matters Fall 2017
THE OTTAWA VALLEY’S HEALTH MAGAZINE HealthMattersFREE! FALL 2017 Eating With A Happy Heart: Advice from the authors of Looneyspooons Local Canadian Experts Health Feature Facts Section: FOOD! Kids Lunch Church Suppers Hacks Around The County! Saving Silas: Meet a little boy who was The Food born with the will to live Crossword In honour of Canada’s 150th, we Canada 150 are trying to attract 150 aircraft to fly-in to the airport on one day! FLY-IN Come Join Us! Thi s goi is g n to be a very o c ay. ol d September 23rd | 10am-3pm This is a FREE event to attend. Pembroke & Area Lunch is available for purchase. AIRPORTT Plus: Ry-J’s, Aircraft Simulator, 49 Years in Aviation. and Canadian Forces aircraft on display! Easy parking in the Expo 150 field across from the airfield. Seating available at the airfield. Meet local and visiting pilots who are flying-in on this special day. 176 Len Hopkins Drive, Petawawa. Visit www.flycyta.ca/Canada150 or www.facebook.com/flycyta. Pembroke & Area AIRPORTT 49 Years in Aviation. FROM THE PUBLISHER FALL 2017 A Letter From Audrey Reader’s handwritten letter says it best about the Health Matters vision as we complete our fifth year After our last issue, I received a handwritten Ottawa Valley, even lifetime residents are letter in the mail from a woman named Audrey. unaware of! You do an excellent job of It was so compelling that I realized I could not bringing them to light, so more residents can do a better job than she did for the Publisher’s use them to make their lives better. -
Maud Menten, a Physician and Biochemist
Maud Menten Canadian medical researcher Maud Menten (1879-1960) has been called the "grandmother of biochemistry," a "radical feminist 1920s flapper," and a "petite dynamo." Not only was she an author of Michaelis-Menten equation for enzyme kinetics (like the plot in indigo in my portrait), she invented the azo-dye coupling for alkaline phosphatase, the first example of enzyme histochemistry, still used in histochemistry imaging of tissues today (which inspired the histology background of the portrait), and she also performed the first electrophoretic separation of blood haemoglobin in 1944! Born in Port Lambton, Ontario, she studied at the University of Toronto, earning her bachelor's in 1904, and then graduated from medical school (M.B., bachelor's of medicine) in 1907. She published her first paper with Archibald Macallum, the Professor of Physiology at U of T (who went on to set up the National Research Council of Canada), on the distribution of chloride ions in nerve cells in 1906. She worked a year at the Rockefeller Institute in New York, where along with Simon Flexner, first director of the Institute, she co-authored a book on radium bromide and cancer, the first publication produced by the Institute - barely 10 years after Marie Curie had discovered radium. She completed the first of two fellowships at Western Reserve University (now Case Western Reserve University), then she earned a doctorate in medical research in 1911 at U of T. She was one of the first Canadian women to earn such an advanced medical degree. She then moved to Berlin (travelling by boat, unfazed by the recent sinking of the Titanic) to work with Leonor Michaelis. -
Maud Leonora Menten
Regulars Past Times A woman at the dawn of biochemistry Maud Leonora Menten Athel Cornish-Bowden Ask an average biochemist who was the first to realize that variant proteins could be detected by (Bioénergétique et Ingénierie electrophoresis and sedimentation, and had used this understanding to recognize different forms of des Protéines, CNRS and haemoglobin, the reply would probably refer to Linus Pauling and his work on sickle cell disease. Yet, Aix-Marseille Université, although this work was certainly important, that would be the wrong answer, because Maud Leonora France) and John Lagnado Menten, who sometimes seems to be remembered for one paper only, had this idea several years (Honorary Archivist, the before him, and used it to recognize the differences between foetal and adult haemoglobin1. She was Biochemical Society) unfortunate, however, in that her paper appeared in war time, and was eclipsed a few years later by a far more high-profile study2. In 2013 we celebrate two important centenaries not only of Director, and later the person who appointed Leonor the admission of women to the Biochemical Society (why Michaelis to his position there. With Flexner and James W. did it take so long?), but also of the publication of a paper Jobling, she wrote a book (the first monograph emanating by Maud Menten, who was one of the first women to leave from the Rockefeller Institute) on the effects of radium her mark in biochemistry, with a paper that is cited more bromide on tumours of animals, published in 1910 – often in the 21st Century than it was in the 20th. -
Calendar Is Brought to You By…
A Celebration of Canadian Healthcare Research Healthcare Canadian of Celebration A A Celebration of Canadian Healthcare Research Healthcare Canadian of Celebration A ea 000 0 20 ar Ye ea 00 0 2 ar Ye present . present present . present The Alumni and Friends of the Medical Research Council (MRC) Canada and Partners in Research in Partners and Canada (MRC) Council Research Medical the of Friends and Alumni The The Alumni and Friends of the Medical Research Council (MRC) Canada and Partners in Research in Partners and Canada (MRC) Council Research Medical the of Friends and Alumni The The Association of Canadian Medical Colleges, The Association of Canadian Teaching Hospitals, Teaching Canadian of Association The Colleges, Medical Canadian of Association The The Association of Canadian Medical Colleges, The Association of Canadian Teaching Hospitals, Teaching Canadian of Association The Colleges, Medical Canadian of Association The For further information please contact: The Dean of Medicine at any of Canada’s 16 medical schools (see list on inside front cover) and/or the Vice-President, Research at any of Canada’s 34 teaching hospitals (see list on inside front cover). • Dr. A. Angel, President • Alumni and Friends of MRC Canada e-mail address: [email protected] • Phone: (204) 787-3381 • Ron Calhoun, Executive Director • Partners in Research e-mail address: [email protected] • Phone: (519) 433-7866 Produced by: Linda Bartz, Health Research Awareness Week Project Director, Vancouver Hospital MPA Communication Design Inc.: Elizabeth Phillips, Creative Director • Spencer MacGillivray, Production Manager Forwords Communication Inc.: Jennifer Wah, ABC, Editorial Director A.K.A. Rhino Prepress & Print PS French Translation Services: Patrice Schmidt, French Translation Manager Photographs used in this publication were derived from the private collections of various medical researchers across Canada, The Canadian Medical Hall of Fame (London, Ontario), and First Light Photography (BC and Ontario). -
Sunnybrook Department of Medicine Annual Report 2012
DEPARTMENT OF MEDICINE ANNUAL REPORT July 1, 2012 – June 30, 2013 Sunnybrook DEPARTMENT OF MEDICINE DEPARTMENT OF MEDICINE ANNUAL REPORT July 1, 2012 – June 30, 2013 Table of Contents MESSAGE FROM THE PHYSICIAN-IN-CHIEF 3 APPENDIXES 37 EXECUTIVE SUMMARY 4 APPENDIX I: LIST OF FACULTY 38 ABOUT US: 4 APPENDIX II: SUMMARY ACTIVITY REPORTS 40 MEMBERS OF THE EXECUTIVE COMMITTEE 6 OVERALL DEPARTMENTAL SUMMARY 41 COMMITTEE REPORTS 7 DIVISION OF CARDIOLOGY 42 DIVISION OF DERMATOLOGY 55 FACULTY 9 DIVISION OF ENDOCRINOLOGY FULL-TIME FACULTY BY DIVISION 9 AND METABOLISM 58 FULL-TIME FACULTY BY UNIVERSITY RANK 10 DIVISION OF GASTROENTEROLOGY 62 FULL-TIME FACULTY BY JOB DESCRIPTION 10 DIVISION OF GENERAL INTERNAL MEDICINE 66 NEW APPOINTMENTS 11 DIVISION OF GERIATRIC MEDICINE 77 PROMOTIONS 11 DIVISION OF INFECTIOUS DISEASES 79 2013 DEPARTMENT OF MEDICINE AWARD RECIPIENTS 12 DIVISION OF MEDICAL ONCOLOGY AND EXTERNAL LEADERSHIP POSITIONS 12 HEMATOLOGY 88 FACULTY WELL-BEING COMMITTEE 13 DIVISION OF NEPHROLOGY 110 STRATEGIC PLAN 14 DIVISION OF NEUROLOGY 116 SHORT-TERM GOALS 2013-2014 15 DIVISION OF PHYSIATRY, PHYSICAL MEDICINE AND REHABILITATION 131 DIVISION REPORTS 16 DIVISION OF RESPIROLOGY 132 CARDIOLOGY 17 DIVISION OF RHEUMATOLOGY 136 CLINICAL PHARMACOLOGY & TOXICOLOGY 19 MISSION, VISION & VALUES STATEMENTS 139 DERMATOLOGY 20 MISSION 139 ENDOCRINOLOGY 21 VISION 139 GASTROENTEROLOGY 23 VALUES 139 GENERAL INTERNAL MEDICINE 25 ORGANIZATION CHART 139 GERIATRIC MEDICINE 26 INFECTIOUS DISEASES 28 MEDICAL ONCOLOGY & CLINICAL HEMATOLOGY 29 NEPHROLOGY 30 NEUROLOGY 31 OBSTETRICAL MEDICINE 32 REHABILITATION MEDICINE 33 RESPIROLOGY 35 RHEUMATOLOGY 36 2 MESSAGE FROM THE PHYSICIAN-IN-CHIEF I am pleased to share this annual report for the 2012-13 academic year with you. -
Structural Genomics in North America
© 2000 Nature America Inc. • http://structbio.nature.com perspectives Structural genomics in North America Thomas C. Terwilliger Structural genomics in North America has moved remarkably quickly from ideas to pilot projects. Just three years ago, the field was only a concept, independently being discussed by its many inventors. Now it is already a well- organized, increasingly-funded, consortium-based effort to determine protein structures on a large scale. The pivotal point for the North American folds, or proteins from fully-sequenced organisms such as yeast efforts was the 1998 Argonne meeting (see or Haemophilus influenzae that held the promise of yielding Table 1 for a timeline of structural important functional information from protein structures. genomics in North America). This meeting All the pilot projects have used more or less the same initial brought together over 80 researchers and strategy: cloning many genes and finding the ones that were high- representatives of funding agencies who ly suitable for structure determination. This process consisted of .com thought that improvements in technology, finding those genes that express well in a simple system, selecting combined with the successes of the genome from this set ones that produce protein in soluble form, testing sequencing projects, had set the stage for a large-scale structure these for crystallization or NMR spectra, and determining the determination project. Experts in all the required steps, from structures of the ones that pass all these tests. All of the projects protein expression to X-ray and NMR structure determination, have found that this process leads to a huge attrition rate at each described recent progress and how the obstacles remaining in step, with three-dimensional structures obtained for just 5–20% their areas could be overcome. -
By the Numbers Excellence, Innovation, Leadership: Research at the University of Toronto a Powerful Partnership
BY THE NUMBERS EXCELLENCE, INNOVATION, LEADERSHIP: RESEARCH AT THE UNIVERSITY OF TORONTO A POWERFUL PARTNERSHIP The combination of U of T and the 10 partner hospitals affiliated with the university creates one of the world’s largest and most innovative health research forces. More than 1,900 researchers and over 4,000 graduate students and postdoctoral fellows pursue the next vital steps in every area of health research imaginable. UNIVERSITY OF TORONTO Sunnybrook Health St. Michaelʼs Sciences Centre Hospital Womenʼs College Bloorview Kids Hospital Rehab A POWERFUL PARTNERSHIP Baycrest Mount Sinai Hospital The Hospital University Health for Sick Children Network* Centre for Toronto Addiction and Rehabilitation Mental Health Institute *Composed of Toronto General, Toronto Western and Princess Margaret Hospitals 1 UNIVERSITY OF TORONTO FACULTY EXCELLENCE U of T researchers consistently win more prestigious awards than any other Canadian university. See the end of this booklet for a detailed list of awards and honours received by our faculty in the last three years. Faculty Honours (1980-2009) University of Toronto compared to awards held at other Canadian universities International American Academy of Arts & Sciences* Gairdner International Award Guggenheim Fellows National Academies** Royal Society Fellows Sloan Research Fellows American Association for the Advancement of Science* ISI Highly-Cited Researchers*** 0 20 40 60 801 00 Percentage National Steacie Prize Molson Prize Federal Granting Councilsʼ Highest Awards**** Killam Prize Steacie -
Printable List of Laureates
Laureates of the Canadian Medical Hall of Fame A E Maude Abbott MD* (1994) Connie J. Eaves PhD (2019) Albert Aguayo MD(2011) John Evans MD* (2000) Oswald Avery MD (2004) F B Ray Farquharson MD* (1998) Elizabeth Bagshaw MD* (2007) Hon. Sylvia Fedoruk MA* (2009) Sir Frederick Banting MD* (1994) William Feindel MD PhD* (2003) Henry Barnett MD* (1995) B. Brett Finlay PhD (2018) Murray Barr MD* (1998) C. Miller Fisher MD* (1998) Charles Beer PhD* (1997) James FitzGerald MD PhD* (2004) Bernard Belleau PhD* (2000) Claude Fortier MD* (1998) Philip B. Berger MD (2018) Terry Fox* (2012) Michel G. Bergeron MD (2017) Armand Frappier MD* (2012) Alan Bernstein PhD (2015) Clarke Fraser MD PhD* (2012) Charles H. Best MD PhD* (1994) Henry Friesen MD (2001) Norman Bethune MD* (1998) John Bienenstock MD (2011) G Wilfred G. Bigelow MD* (1997) William Gallie MD* (2001) Michael Bliss PhD* (2016) Jacques Genest MD* (1994) Roberta Bondar MD PhD (1998) Gustave Gingras MD* (1998) John Bradley MD* (2001) Phil Gold MD PhD (2010) Henri Breault MD* (1997) Richard G. Goldbloom MD (2017) G. Malcolm Brown PhD* (2000) Jean Gray MD (2020) John Symonds Lyon Browne MD PhD* (1994) Wilfred Grenfell MD* (1997) Alan Burton PhD* (2010) Gordon Guyatt MD (2016) C H G. Brock Chisholm MD (2019) Vladimir Hachinski MD (2018) Harvey Max Chochnov, MD PhD (2020) Antoine Hakim MD PhD (2013) Bruce Chown MD* (1995) Justice Emmett Hall* (2017) Michel Chrétien MD (2017) Judith G. Hall MD (2015) William A. Cochrane MD* (2010) Michael R. Hayden MD PhD (2017) May Cohen MD (2016) Donald O. -
Appendix 13 Faculty of Medicine
Appendix 13 Faculty of Medicine: Faculty Awards and Honours 2010-2018 Surname GivenName Home Unit Division Award Organization NominationStatus AwardStartDate Semple John Department of Surgery Faculty of Medicine Leading Practice Award Accreditation Canada Awarded 01-Jan-11 Pain Clare Department of Psychiatry Faculty of Medicine Honorary Doctorate of Science Addis Ababa University Awarded 01-Jan-14 Lefebvre Julie Department of Molecular Genetics Faculty of Medicine Sloan Research Fellowship Alfred P. Sloan Foundation Awarded 23-Feb-15 MacLennan David Banting & Best Department of Medical Research Faculty of Medicine Foreign Honorary Member American Academy of Arts and Sciences Awarded 22-Apr-15 Nodwell Justin Department of Biochemistry Faculty of Medicine Fellow American Academy of Microbiology Awarded 05-Jan-18 Cowen Leah Department of Molecular Genetics Faculty of Medicine Fellow American Academy of Microbiology Awarded 05-Jan-18 Andrews Brenda Jean Donnelly Centre for Cellular & Biomolecular Research Faculty of Medicine Fellow American Academy of Microbiology Awarded 01-Jan-12 Boone Charlie Donnelly Centre for Cellular & Biomolecular Research Faculty of Medicine Fellow American Academy of Microbiology Awarded 01-Jan-12 Lim Andrew Department of Medicine Faculty of Medicine Wayne A. Hening Sleep Medicine Investigator Award American Academy of Neurology Awarded 01-Jan-13 Watson C Peter Department of Medicine Faculty of Medicine Mitchell B. Max Award for Neuropathic Pain American Academy of Neurology Awarded 28-Apr-17 Classen Catherine Department -
Using Mathematical Modelling and Electrochemical Analysis to Investigate Ageassociated Disease
Using Mathematical Modelling and Electrochemical Analysis to Investigate AgeAssociated Disease Item Type Thesis or dissertation Authors Morgan, Amy Citation Morgan, A. E. (2019). Using Mathematical Modelling and Electrochemical Analysis to Investigate AgeAssociated Disease. (Doctoral dissertation). University of Chester, United Kingdom. Publisher University of Chester Rights Attribution-NonCommercial-NoDerivatives 4.0 International Download date 04/10/2021 12:00:32 Item License http://creativecommons.org/licenses/by-nc-nd/4.0/ Link to Item http://hdl.handle.net/10034/622177 Using Mathematical Modelling and Electrochemical Analysis to Investigate Age‐Associated Disease Thesis submitted in accordance with the requirements of the University of Chester for the degree of Doctor of Philosophy By Amy Elizabeth Morgan MRes, BSc (Hons), PGCertLTHE, FHEA March 2019 University of Chester Thornton Science Park Pool Lane Ince Chester CH2 4NU 1 Declaration The material being presented for examination is my own work and has not been submitted for an award of this or another HEI except in minor particulars which are explicitly noted in the body of the thesis. Where research pertaining to the thesis was undertaken collaboratively, the nature and extent of my individual contribution has been made explicit. Signed: …………………………………………………….. Date: ……………………………………………………….. 2 Acknowledgements I would like to thank my family, friends, colleagues, and supervisory team for their continued support throughout this journey. I would also like to thank the University of Chester for internally funding this PhD, without which, this would not have been possible. Further thanks go to the Institute of Medicine, University of Chester, for donating the MCF‐7 cells and providing support with cell culturing. -
More Than Microscopes: the DIFFERENCE CANADIANS MAKE SAVING LIVES THROUGH MEDICAL RESEARCH
More Than Microscopes: THE DIFFERENCE CANADIANS MAKE SAVING LIVES THROUGH MEDICAL RESEARCH healthpartners.ca 150 YEARS … 150 MEDICAL RESEARCH ADVANCES … $150 MILLION RAISED: Canadian Researchers Make a Mark Here — and Around the World Rick Perciante, Chair, Eileen Dooley Board of Directors CEO, HealthPartners HealthPartners Pablum to improve infant nutrition. The ability of Without a breakthrough using stem cell-based T-cells to destroy bacteria and viruses and marshal therapy to treat aggressive forms of relapsing- the immune system. The Cobalt-60 ‘bomb’ to remitting multiple sclerosis, Jennifer Molson kill cancer cells. Controlled gene mutation. The wouldn’t have been able to participate in a link between stress and disease. Insulin to treat bone marrow transplant trial, which essentially diabetes. Child-resistant medical containers. transformed her life. Without ground-breaking Discovery of stem cells. drug therapies, eight-year-old Kaiden Ames would probably not be alive today, and his Despite an overall population of fewer than parents wouldn’t have the chance to see him 40 million, Canada has nurtured a striking number grow up and even be a parent himself. Without of scientists and researchers whose breakthrough deep brain stimulation surgery, Herb Durand medical discoveries — and their ongoing wouldn’t be able to fulfill a long-time dream: to contributions to medical knowledge — have hold his grandchild. And without the tremendous improved, or have the potential to improve, the strides that have been made in diabetes research, health of millions of people around the world, not Dwayne Vermette certainly wouldn’t be living a just across our vast country. healthy lifestyle after being diagnosed with type 2 diabetes in his 30s — including having the ability HealthPartners is proud to play a leadership role to manage his condition with pills rather than a in connecting donor dollars to life-enhancing and daily injection of insulin. -
2006-2007 Annual Report
2007 annual report 1 April 06 - 31 March 07 the future is in our genes. Chairman’s Message 02 President’s Message 04 OGI’s Mission 06 Research Programs Genetic Basis of Human Health 08 Biomarkers 12 Infectious Diseases and Promoting Global Health 14 Biodiversity, the Environment and Looking Ahead 16 Research Programs 18 Business Development Investments 20 Science - Industry Workshops 22 Outreach Public Outreach and Next Generation Innovators 24 Reaching Out Through The Arts 26 Workshops and Talks 28 Operations Board of Directors and Staff 29 Financial Snapshot 30 Financial Statements (inserted into flap at back) Copyright 2007 Ontario Genomics Institute 2007 annual report • 01 Chairman’s Message As Chair of the Ontario Genomics Institute (OGI), I am teomics research and to the growing cadre of internation- proud to report that the past year was for OGI a very posi- ally-recognized scientific researchers in this province whose tive reflection of our goal of augmenting -- through our knowledge and technical prowess are driving leading-edge focus on the genomics sector -- Ontario’s role as a pre- genomics research that will, in the long run, benefit all eminent centre in the life sciences industry. Now entering Canadians and help sustain and improve us economically. its seventh year, OGI continues to realize the benefits of sound strategic thinking, a clear direction, broad and fruit- Other partnerships have also been crucial. As always, the ful strategic partnerships, excellent recruitment and the partnerships with the various universities, research hospitals strong support of its major stakeholders. and other life science research institutions in Ontario (and beyond) has been of paramount importance.