Genomics has increased our understanding of the human body and disease, leading to improved diagnoses, treatments and longer, healthier lives. Project Portfolio
12 ONTARIO GENOMICS INSTITUTE 2012 ANNUAL REPORT Project Portfolio
Projects actively funded in 2011–2012
Biomonitoring 2.0: Genomics for Crop Structural Genomics A high-throughput Improvement: Agricultural Consortium (SGC) – genomics approach to Pest Management Phase III comprehensive biological Y Miodrag Grbic Y Aled Edwards assessment of University of Western Ontario, University of Toronto environmental change London University of Oxford (UK) Y Mehrdad Hajibabaei October 2009 – September 2013 July 2011 – June 2012 University of Guelph $6.3 million $16.2 million July 2011 – June 2014 $3.1 Million Bioproducts and Enzymes from Structural Genomics Environmental Metagenomes Consortium (SGC) – Phase II NorCOMM2 – In vivo models (BEEM) Y Aled Edwards for human disease and Y Elizabeth Edwards University of Toronto drug discovery University of Toronto University of Oxford (UK) Y Colin McKerlie Y David Major Karolinska Institute, Stockholm Mount Sinai Hospital, Toronto Geosyntec Consultants, Guelph (Sweden) Y Steve Brown October 2009 – September 2013 July 2007 – June 2011 Medical Research Council $11.0 million $118.5 million Harwell (UK) July 2011 – June 2014 Finding of Rare Disease Genes Structural and Functional $10.9 Million in Canada (FORGE Canada) Annotation of the Human Y Kym Boycott Genome for Disease Study Synthetic antibody program: Children’s Hospital of Eastern Y Robert Hegele commercial reagents and Ontario Research Institute, Ottawa Robarts Research Institute, London novel therapeutics April 2011 – March 2013 October 2006 – June 2011 Y Sachdev Sidhu, Charles Boone $4.1 Million $21.6 million University of Toronto July 2011 – June 2014 The Centre for Applied $9.9 Million Genomics (TCAG) Dollar amounts are total approved Science and Technology project costs as of March 31, 2012 Therapeutic Opportunities to Innovation Centre Target Tumor Initiating Cells in Y Stephen Scherer Solid Tumors Hospital for Sick Children, Toronto Y Tak Mak January 2006 – March 2013 University Health Network, Toronto $14.4 million June 2010 – May 2014 $40.0 million International Barcode of Life (iBOL) Development of Highly Active Y Paul Hebert Anti-Leukemia Stem Cell University of Guelph Therapy (HALT) July 2008 – December 2012 Y John Dick, Jean Wang $19.8 million University Health Network, Toronto April 2010 – March 2014 $31.8 million
2012 ANNUAL REPORT ONTARIO GENOMICS INSTITUTE 13 Project Portfolio
Previously completed projects
Identification of Genetic Automated Three-dimensional The Contribution of Genetic Pathways that Regulate the Phenotyping of Mouse Embryos Modulators of Disease Severity Survival and Development of Y Mark Henkelman in Cystic Fibrosis to Other Cancer and Cancer Stem Cells Hospital for Sick Children, Toronto Diseases with Similarities of Y Cynthia Guidos April 2008 – September 2010 Clinical Phenotype Hospital for Sick Children, Toronto $1.4 million Y Peter Durie, Julian Zielenski January 2006 – March 2011 Hospital for Sick Children, Toronto $18.7 million The Dynactome: Mapping April 2006 – June 2010 Spatio-Temporal Dynamic $7.6 million Genome-Environment Systems in Humans Interactions in Type I Diabetes Y Anthony Pawson, Jeff Wrana Technologies for Y Jayne Danska Samuel Lunenfeld Methylome Studies Hospital for Sick Children, Toronto Research Institute, Y Arturas Petronis Y Andrew Macpherson Mount Sinai Hospital, Toronto Centre for Addiction and Mental McMaster University, Hamilton Y Shawn Li Health, Toronto January 2006 – March 2011 University of Western Ontario, April 2008 – March 2010 $15.1 million London $0.8 million January 2006 – June 2010 Autism Genome Project $27.6 million Proteomic Technologies for Y Stephen Scherer the Study of Rare Cells Hospital for Sick Children, Toronto Software Tools to Simplify Gene Y Daniel Figeys January 2006 – March 2011 Function Prediction University of Ottawa $15.6 million Y Gary Bader, Quaid Morris April 2008 – March 2010 University of Toronto $1.5 million Strengthening the Role of April 2008 – June 2010 Genomics and Global Health $1.9 million Massively Multiparametric Y Peter Singer, Abdallah Daar Flow Cytometer Analyzer University of Toronto Environmental Barcoding Y Scott Tanner April 2006 – December 2010 through Massively Parallelized University of Toronto $10.4 million Sequencing April 2008 – March 2010 Y Paul Hebert $2.8 million Quantum Dot Diagnostics: University of Guelph Simultaneous Genomic and April 2008 – June 2010 Integrative Biology Proteomic Profiling of Multiple $1.8 million Y Brenda Andrews Pathogens at Point-of-Care University of Toronto Y Kevin Kain Multiplexed MicroRNA January 2006 – December 2009 University Health Network, Toronto Detection on an Electronic Chip $26.8 million Y Michael Greenberg Y Shana Kelley, Ted Sargent Fio Corporation, Toronto University of Toronto January 2006 – September 2010 April 2008 – June 2010 $9.9 million $0.9 million
14 ONTARIO GENOMICS INSTITUTE 2012 ANNUAL REPORT Project Portfolio
Previously completed projects
International Regulome Segmental Duplications Genomics of the Consortium (IRC) in Neurodevelopmental, Spruce Budworm and its Y Michael Rudnicki Neurological and Behavioural Viral Pathogens Ottawa Health Research Institute Disorders Y Arthur Retnakaran, Basil Arif January 2008 – June 2009 Y Stephen Scherer Great Lakes Forestry Centre – NRC, $23.0 million Hospital for Sick Children, Toronto Sault Ste. Marie Y Xavier Estivill January 2003 – March 2006 Canadian Barcode of Centro de Regulació Genòmica, $4.6 million Life Network Barcelona Y Paul Hebert April 2004 – September 2007 Bridging the Emerging University of Guelph $5.2 million Genomics Divide April 2005 – June 2009 Y Peter Singer, Abdallah Daar $11.0 million Structural Genomics University of Toronto Consortium (SGC) – Phase I January 2003 – March 2006 Mass Spectrometer-based Y Aled Edwards $2.8 million Flow Cytometer, Methods and University of Toronto Applications University of Oxford (UK) Mapping and Isolation of Genes Y John Dick Karolinska Institute, Stockholm Influencing Severity of Disease University Health Network, Toronto (Sweden) in Cystic Fibrosis January 2005 – March 2008 July 2003 – June 2007 Y Peter Durie, Lap-Chee Tsui $7.8 million $105.0 million Hospital for Sick Children, Toronto October 2002 – March 2006 Protein Expression Profiling Genetic Determinants of $6.4 million Platform for Heart Disease Human Health and Disease Biomarker Discovery Y Katherine Siminovitch Functional Genomics of Y Peter Liu, Andrew Emili, Samuel Lunenfeld Research Type 1 Diabetes David MacLennan Institute, Mount Sinai Hospital, Y Jayne Danska University of Toronto Toronto Hospital for Sick Children, Toronto April 2004 – December 2007 January 2003 – June 2006 January 2003 – March 2006 $6.0 million $11.0 million $8.5 million
Assessing Risk for Colorectal Genomic Analysis of Soil The Stem Cell Genomics Project Tumours in Canada (ARCTIC) Microorganisms Y Michael Rudnicki Y Brent Zanke Y Turlough Finan, Brian Golding Ottawa Health Research Institute Cancer Care Ontario, Toronto McMaster University, Hamilton July 2002 – March 2006 Y Tom Hudson January 2003 – March 2006 $11.1 million McGill University and $5.9 million Génome Québec Proteomics and Innovation Centre, Montreal Functional Genomics – October 2004 – December 2007 An Integrated Approach $9.6 million Y Brenda Andrews, Cheryl Arrowsmith University of Toronto July 2002 – March 2006 $15.0 million
2012 ANNUAL REPORT ONTARIO GENOMICS INSTITUTE 15 Project Portfolio
Previously completed projects
Functional Genomics and Proteomics Technology Functional Genomics of Proteomics of Model Organisms Core Facility (PTCF) Arabidopsis Y Jack Greenblatt, Andrew Y Jack Greenblatt Y John Coleman Spence, Brenda Andrews University of Toronto University of Toronto University of Toronto Y Gilles Lajoie July 2002 – September 2005 October 2001 – March 2006 University of Western Ontario, $1.8 million $26.5 million London October 2001 – December 2005 Fiber Optic Nucleic Acid (FONA) Development and Applications $8.6 million Biosensor-based Gene Profiling: of Functional Genomics Proof of Principle by Screening Technologies Genetic Determinants of Human for Drug Leads for Orphan Y James Woodgett Health and Disease – Annotation Neurodegenerative Disorders University Health Network, Toronto of Chromosome 7 and SNP Analysis October 2002 – December 2005 Y Stephen Scherer Y Alex MacKenzie $8.8 million Hospital for Sick Children, Toronto Children’s Hospital of Eastern October 2001 – September 2005 Ontario, Ottawa The Biomolecular Interaction $1.8 million Y Paul Piunno, Ulrich Krull Network Database (BIND) University of Toronto at Mississauga Y Christopher Hogue Canadian Program on Genomics July 2002 – June 2005 Samuel Lunenfeld Research and Global Health $2.8 million Institute, Mount Sinai Hospital, Y Peter Singer, Abdallah Daar Toronto University of Toronto Viral Proteomics April 2002 – December 2005 October 2001 – September 2005 Y Lori Frappier, Christian Burks $23.1 million $6.2 million Affinium Pharmaceuticals, Toronto July 2002 – December 2004 Genomic Resource Core Facility Functional Genomics and $6.3 million Y Stephen Scherer, Lap-Chee Tsui Proteomics of Model Organisms Hospital for Sick Children, Toronto Y Janet Rossant, Anthony October 2001 – December 2005 Pawson Dollar amounts are total approved $18.0 million Samuel Lunenfeld Research project costs Institute, as of March 31, 2012 Mount Sinai Hospital, Toronto October 2001 – September 2005
16 ONTARIO GENOMICS INSTITUTE 2012 ANNUAL REPORT