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The Structural Genomics Consortium a Knowledge Platform for Drug Discovery CHILDREN AND FAMILIES The RAND Corporation is a nonprofit institution that helps improve policy and EDUCATION AND THE ARTS decisionmaking through research and analysis. ENERGY AND ENVIRONMENT HEALTH AND HEALTH CARE This electronic document was made available from www.rand.org as a public INFRASTRUCTURE AND service of the RAND Corporation. TRANSPORTATION INTERNATIONAL AFFAIRS LAW AND BUSINESS NATIONAL SECURITY Skip all front matter: Jump to Page 16 POPULATION AND AGING PUBLIC SAFETY SCIENCE AND TECHNOLOGY Support RAND TERRORISM AND Browse Reports & Bookstore HOMELAND SECURITY Make a charitable contribution For More Information Visit RAND at www.rand.org Explore RAND Europe View document details Limited Electronic Distribution Rights This document and trademark(s) contained herein are protected by law as indicated in a notice appearing later in this work. 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The Structural Genomics Consortium A knowledge platform for drug discovery Molly Morgan Jones, Sophie Castle-Clarke, Daniel Brooker, Eddy Nason, Farah Huzair and Joanna Chataway RESEARCH REPORT The Structural Genomics Consortium A knowledge platform for drug discovery Molly Morgan Jones, Sophie Castle-Clarke, Daniel Brooker, Eddy Nason, Farah Huzair and Joanna Chataway RAND Europe with The Institute on Governance RR-512-SGC March 2014 PREPARED FOR THE STRUCTURAL GENOMICS CONSORTIUM This is an independent report. The research described in this report was prepared for and primarily funded by the Structural Genomics Consortium. It was also funded in part by the Policy Research Programme in the Department of Health. The views expressed are not necessarily those of the Department. RAND Europe is an independent, not-for-profit policy research organisation that aims to improve policy and decisionmaking for the public interest though research and analysis. RAND’s publications do not necessarily reflect the opinions of its research clients and sponsors. R® is a registered trademark © Copyright 2014 RAND Corporation Permission is given to duplicate this document for personal use only, as long as it is unaltered and complete. Copies may not be duplicated for commercial pur- poses. Unauthorized posting of RAND documents to a non-RAND website is prohibited. RAND documents are protected under copyright law. For informa- tion on reprint and linking permissions, please visit the RAND permissions page (www.rand.org/publications/permissions.html). RAND OFFICES SANTA MONICA, CA • WASHINGTON, DC PITTSBURGH, PA • NEW ORLEANS, LA • JACKSON, MS • BOSTON, MA DOHA, QA • CAMBRIDGE, UK • BRUSSELS, BE www.rand.org • www.rand.org/randeurope Preface Since its establishment as a not-for-profit, multi- • What are the most convincing arguments in national public-private partnership in 2004, the favour of current funding of the SGC? Structural Genomics Consortium (SGC) has • What are relative merits of the SGC open been supporting drug discovery efforts through a access model as opposed to alternative models unique, open access model of public-private col- of funding R&D in this space? laboration. Its primary focus has been and con- • What judgements can be made about the SGC’s tinues to be on pre-competitive structural biol- past and current performance track record in ogy research, namely determining the 3D protein light of achievements and expectations? structures of biomedical importance on a large • Are there important trade-offs or limitations scale and cost-effectively. Over time, though, its that need to be addressed looking towards a portfolio has expanded to include chemical probes Phase IV or reasons against funding the SGC? and antibodies, branching out to research studies • In considering a potential Phase IV are funders that aim to deliver open access reagents for epi- anticipating changes internal to the SGC or in genetics research. the wider PPP landscape in this field? The SGC is currently in its third phase (which • What are the key trends and opportunities in ends June 2015), yet little systematic and rigorous the external environment that could influence analysis has been done to understand the nature a Phase IV, and can the SGC benefit from or and diversity of the benefits gained, both for the have influence over these trends? partnering organisations and for the wider research community. In light of this and to determine a RAND Europe is an independent not-for-profit potential next phase for the consortium, the SGC policy research organisation that aims to improve commissioned an evaluation of its current model policy and decisionmaking in the public interest, of operation. A competitive tendering process through research and analysis. RAND Europe’s cli- resulted in RAND Europe and The Institute on ents include European governments, institutions, Governance being asked to carry out this evalu- non-governmental organisations and firms with a ation. The scope of work was extended as a result need for rigorous, independent, multi-disciplin- of a parallel grant from the Department of Health ary analysis. This report has been peer-reviewed (England), Policy Research Programme, who in accordance with RAND’s quality assurance provided extra resource for additional literature standards. review related research. The INNOGEN Institute The Institute on Governance (IOG) is an also contributed by enabling the participation of independent, Canada-based, not-for-profit public Farah Huzair as part of the research team. interest think tank. The IOG is uniquely posi- This report constitutes a completely indepen- tioned to fill the need for knowledge, research and dent assessment and has not been subject to con- advice for better public service delivery and deci- tent review by the SGC or others associated with sionmaking. The IOG’s work is marked by inde- the SGC. The report is intended for a broad audi- pendent thought, innovation, collaboration, part- ence of those with direct and indirect interests in nership, excellence and a responsive and principled the SGC. Its main objective is to answer the fol- approach. The IOG works with a wide range of lowing questions: national and international clients and partners, iv The Structural Genomics Consortium including governments, communities, business, charities and public organisations. For more information about RAND Europe, the Institute on Governance or this document, please contact: Joanna Chataway RAND Europe Westbrook Centre Milton Road Cambridge CB4 1YG United Kingdom Tel. +44 (1223) 353 329 [email protected] or Eddy Nason Institute on Governance 150 Bloor St West Suite 200 Toronto, ON M5S 2X9 Canada Tel./Tél: 647 295-8506 [email protected] Table of Contents Preface .................................................................................................................................... iii Table of Contents .................................................................................................................. v Figures ..................................................................................................................................... vii Tables ....................................................................................................................................... viii Summary ................................................................................................................................. ix Acknowledgements .............................................................................................................. xvi Abbreviations ......................................................................................................................... xvii CHAPTER ONE Introduction ......................................................................................................................... 1 The Structural Genomics Consortium ................................................................................ 1 An independent evaluation of the SGC ............................................................................ 3 Structure of the evaluation report ..................................................................................... 4 CHAPTER TWO The SGC in context: A review of relevant literature ............................................... 7 The literature helped in setting the context for the evaluation ................................... 7 What are the relevant insights about the rationale for open innovation in health innovation and research? ........................................................................................ 8 A comparison of the SGC and other PPPs ......................................................................... 13 Are there lessons to be learnt from open access initiatives in other sectors? ............. 17 Are there implications of peer review as a mechanism for funding health
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