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Paper Iv : Basic Physiology Department of Biochemistry Faculty of Science The M. S. University of Baroda Papers for M. Sc. (Biochemistry) Semester syllabus THEORY SEMESTER - I CREDITS Course Code Basic Biochemistry 03 BCH2101 Protein Structure and Function & Basic Enzymology 03 BCH2102 Cell Biology 03 BCH2103 Basic Physiology 03 BCH2104 Molecular Biology-I 03 BCH2105 Practical I 09 BCH2106 Seminar 01 BCH2107 TOTAL CREDITS 25 THEORY SEMESTER - II CREDITS Course Code Metabolism - I 03 BCH2201 Enzyme Mechanism & Regulation 03 BCH2202 Biophysical Techniques 03 BCH2203 Endocrinology 03 BCH2204 Recombinant DNA Techniques 03 BCH2205 Practical II 10 BCH2206 Seminar 01 BCH2207 TOTAL CREDITS 26 THEORY SEMESTER - III CREDITS Course Code Basic Immunology 03 BCH2301 Metabolism - II 03 BCH2302 Molecular Biology - II 03 BCH2303 Biostatistics & Bioinformatics 03 BCH2304 1. Basic Pharmacology (Optional Paper- I) 03 BCH2305 2. Structural Biology (Optional Paper – I) 03 BCH2306 3. Biochemical Toxicology (Optional Paper – I) 03 BCH2307 Practical III 07 BCH2308 Project Work I 03 BCH2309 Seminar 01 BCH2310 TOTAL CREDITS 26 THEORY SEMESTER - IV CREDITS Course Code Genetics 03 BCH2401 Genetic Engineering & Genomics 03 BCH2402 Molecular Medicine 03 BCH2403 Plant & Microbial Biochemistry (Optional Paper – II) 03 BCH2404 Neurochemistry (Optional Paper – II) 03 BCH2405 Advanced Plant Biochemistry (Optional Paper - II) 03 BCH2406 Microbial Adaptive Biology (Optional Paper - II) 03 BCH2407 Project Work II 10 BCH2408 Viva ( External ) 01 BCH2409 TOTAL CREDITS 23 Total Credits = 100 Biochemistry 1 SEMESTER I BCH2101 BASIC BIOCHEMISTRY Credit-1 Relevance of properties of water for life. Diffusion rates, viscosity; Thermodynamic principles in metabolism; techniques to study metabolic pathways. Carbohydrate Chemistry: Monomers. Structure-function correlation and diversity in various organisms. Credit-2 Carbohydrate Chemistry: Polymers & Modifications and their structure- function correlation; diversity in various organisms; Amino acids Chemistry: structure-function correlation. Credit-3 Chemistry of Lipids & Nucleotides: structure-function correlation. & Modifications; Chemistry of Vitamin and their functions. Books 1. D. Voet (2010) Biochemistry, 4th edition, John Wiley & Sons (ISBN: 978-0-470- 57095-1). 2. D. L. Nelson and M. M. Cox (2007) Lehninger Principles of Biochemistry, Fourth Edition. 3. R. H. Garrett and C. M. Grisham (2008) Biochemistry 4th Edn., Brooks/cole Cengage Learning. 4. Voet, D., Voet, J. G., and Pratt, C. W. (2011) Fundamentals of Biochemistry, 4th Edn., John Wiley & Sons. 5. Haynie, D. T. (2008) Biological Thermodynamics, 2nd Edn., Cambridge Univ. Press. 6. R. R. Crichton (2008) Biological Inorganic Chemistry : An Introduction, Elsevier. 7. G. G. Hammes (2007) Physical chemistry for biological sciences, Wiley-Interscience. 8. Nelson P. (2004) Biological Physics, W. H. Freeman & Co., NY, USA. 9. D. E. Metzler, (2003) Biochemistry, Vol. 1 & II, 2nd Edn., Academic Press. BCH2102 PROTEIN STRUCTURE AND FUNCTION & BASIC ENZYMOLOGY Credit-1 Proteins: Primary structure and determination; artificial peptide synthesis; restrictions on primary structure (recognition sequences for protein modifications and targeting); Chemical modification of side chains of amino acid residues Credit-2 Forces and interactions responsible for protein structure; Secondary and tertiary structure including prediction; quaternary structure. Scope of enzymology, classification and nomenclature. Kinetics: chemical kinetics; Variations of velocity with [E], [S]. Credit-3 Variations of velocity with pH and temperature; enzyme inhibition; bi- substrate reaction kinetics; uses of kinetic studies in determining enzyme mechanism; scope for increasing enzyme efficiency; enzyme specificity. Books 1. Gray (2010) Enzymes Biotechnology, Cbs. 2. C. Koehrer & U. L. RajBhandari (2010) Protein Engineering., Springer, NY. 3. Michael, G. M. (2010) Protein Bioinformatics, Elsevier. 4. D. L. Purich (2009) Contemporary Enzyme Kinetics and Mechanism, 3rd Edn., AP. 5. J. Poliana and A. P MacCabe (2007) Industrial Enzymes – Structure, Function and Applications, Springer. 6. W. Aehle (2007) Enzymes in Industry, Wiley-VCH. 7. P. F. Cook and W. W. Cleland (2007) Enzyme Kinetics and Mechanism. Garland Science. 8. D. Whitford (2005) Proteins: Structure and Function. Wiley Publication. 9. A. Carnish Bowden (2004) Fundamental of Enzyme Kinetics, 3rd Edn., Portland Press. 10. G. A. Petsko and D. Ringe (2003) Protein Structure and Function, New Science Press, Ltd. 11. Metzler, D. E. (2003) Biochemistry, Vol. 1 & II, 2nd Edn., Academic Press. 12. S. P. Trevor (2001) Enzymes, Harwood. 13. Voet, D., Voet, J. and Pratt, C. W. (1999) Fundamentals of Biochemistry. Biochemistry 2 14. Price, N. C. & L. Stevens, (1999) Fundamentals of Enzymology, 3rd Edn., Oxford University Press. 15. H. Uhlig, E. M L. Bednar (1998) Industrial Enzymes and their Applications, Wiley. 16. Creighton, T. E. (1995) Proteins : Structure and Molecular Properties. 17. Fersht, A. R. (1985) Enzyme structure and function, 2nd Edition, W. H. Freeman & Co. NY. 18. Dixon and Webb, (1979) Enzymes. 19. Bayer, Lardy and Myrback, The Enzymes, Academic Press. BC2103 CELL BIOLOGY Credit-1 Introduction to cell; evolution of cell; comparative aspects of prokaryotes and eukaryote, Structure and function of Biomembranes, Types of membrane transport. Cytoskeleton, Cell-cell and Cell-Extracellular matrix interactions. Credit-2 Cellular organelles like Endoplasmic reticulum, Golgi, Mitochondria. Lysosomes. Mechanism of protein translocation, Membrane trafficking, Vesicular transport Credit-3 Eukaryotic Cell signaling- Types of receptors, signal transduction by membrane bound, cytosolic and nuclear receptors via various pathways Books 1. B. Alberts et al. (2010) Essential Cell Biology, 3rd Edn., Garland Science. 2. S. Tompkins (2010) Cell Biology, Appleacademics. 3. T. D. Pollard & W. C. Earnshaw (2008) Cell Biology 2nd Edn., Saunders Elsevier. 4. H. Lodish et al., (2008) Molecular Cell Biology, 6th Edn., W. H. Freeman & Co. NY. USA. 5. K. Roberts, J. Lewis, B. Alberts, P. Walter, A. Johnson and M. Raff. (2008) Molecular Biology of the Cell, 5th Edn., Garland Publishing Inc. New York. 6. Kreitzer, G., F. Jaulin and C. Espenel (2009) Cell Biology Assays: Essential Methods, Academic Press. 7. K. Gerald (2007) Cell and Molecular Biology, Concept and Experiment, 5th Edn., Wiley. BCH2104 BASIC PHYSIOLOGY Credit-1 Blood Chemistry & blood clotting, function of respiratory system and regulation of respiration, Structure & function of digestive system, digestion and absorption, Credit-2 Structure and function of excretory system and role of kidney in urine formation; fluid electrolyte balance. Neurochemistry – Organization of the nervous system in brief:cellular, organ level, organ-system level; Cells of the nervous system, their structure and function Credit-3 Neurochemistry - special biochemical features (structural and metabolic). Ion Channels and electrical properties of membranes; EPSPs & IPSPs; molecular mechanism of generation of membrane potential and action potential & its propagation;synaptic transmission 1. Guyton, Text book of Medical Physiology, 1998 2. Kelly, Hormones, 1994 3. Ganong, Review of medical physiology, 1997 4. Tortora, G. J. Principles of anatomy and physiology, 2000 5. Devlin, T. M. Text of biochemistry with clinical correlations, 1997 6. Harper, Biochemistry, 1997 7. Aidley. 8. Kuffler and Nichols. From Neuron to Brain. 9. Zigmond. 10. Kandel and Schwartz 11. Siegel. Basic Neurochemistry 12. Nerve, Muscle & Synapse. Katz, B. (1964?). 13. Neuroscience_Bear_Connors_Paradiso_3ed_2007.—added 26thSept.’10. 14. Molecular Biology of the Cell. Alberts B et al.(for ALL basics). Biochemistry 3 BCH2105 MOLECULAR BIOLOGY- I Credit-1 Nucleic acids and Genome: The central dogma, evidence that DNA is the genetic material. Structure of DNA and RNA, physical properties of DNA- cot plot, kinetic and chemical complexity, Tm, buoyant density, satellite DNA. Organization of the human genome. Chromosome, structure of chromatin- nucleosomes, solenoids, scaffolds. Credit-2 Chromatin domains and isochores, structure and functional organization of centromeres and telomeres. Transcription : Structure of genes, promoters, enhancers. Structure and mode of action of E. coli RNA polymerase and eukaryotic RNA polymerase I. Credit-3 Structure and mode of action of RNA polymerases II and III. Co- and -post transcriptional modifications in prokaryotes and eukaryotes. Regulation of transcription in prokaryotes and eukaryotes. Books 1. B. Lewin, J. E. Krebs, E. S. Goldstein and S. T. Kilpatrick (2009) Lewin’s Essential Genes, 2nd Edn., Jones & Barlett Pub., USA. 2. R. Weaver (2007) Molecular Biology, 4th Edn., McGraw-Hill. 3. J. D. Watson, T. A. Baker, S. P. Bell, A. Gann, M. Levine, R. Losik and Inglis, CSHLP (2007) Molecular Biology of the Gene, 6th Edition, Benjamin Cummings. 4. D. Clark (2009) Molecular Biology: Academic Cell, Academic Press. 5. J. E. Krebs, E. S. Goldstein and S. T. Kilpatrick (2009) Lewin’s Genes X, 10th Edn., Jones & Barlett Pub., USA. 6. Twyman, R. M. (1998) Advanced Molecular Biology, Bioscientific Publ. BCH2106 Practical I (9 Credits) 1. Orientation 2. Tissue Analysis 3. Protein purification 4. Basic Enzymology 5. Immunology Biochemistry 4 Semester II BCH2201 METABOLISM I (3 Credits) Credit-1 Carbohydrate Metabolism (organization, reactions, regulation etc.)- Glycolysis, Glycogenolysis, Glycogenesis & Gluconeogenesis; HMP, Entner-Doudoroff, Glyoxylate and Poylol pathways.
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