Dynamics of Excitatory-Inhibitory Neuronal Networks With

Total Page:16

File Type:pdf, Size:1020Kb

Dynamics of Excitatory-Inhibitory Neuronal Networks With I (X;Y) = S(X) - S(X|Y) in c ≈ p + N r V(t) = V 0 + ∫ dτZ 1(τ)I(t-τ) P(N) = 1 V= R I N! λ N e -λ www.cosyne.org R j = R = P( Ψ, υ) + Mγ (Ψ, υ) σ n D +∑ j n k D k n MAIN MEETING Salt Lake City, UT Feb 27 - Mar 2 ................................................................................................................................................................................................................. Program Summary Thursday, 27 February 4:00 pm Registration opens 5:30 pm Welcome reception 6:20 pm Opening remarks 6:30 pm Session 1: Keynote Invited speaker: Thomas Jessell 7:30 pm Poster Session I Friday, 28 February 7:30 am Breakfast 8:30 am Session 2: Circuits I: From wiring to function Invited speaker: Thomas Mrsic-Flogel; 3 accepted talks 10:30 am Session 3: Circuits II: Population recording Invited speaker: Elad Schneidman; 3 accepted talks 12:00 pm Lunch break 2:00 pm Session 4: Circuits III: Network models 5 accepted talks 3:45 pm Session 5: Navigation: From phenomenon to mechanism Invited speakers: Nachum Ulanovsky, Jeffrey Magee; 1 accepted talk 5:30 pm Dinner break 7:30 pm Poster Session II Saturday, 1 March 7:30 am Breakfast 8:30 am Session 6: Behavior I: Dissecting innate movement Invited speaker: Hopi Hoekstra; 3 accepted talks 10:30 am Session 7: Behavior II: Motor learning Invited speaker: Rui Costa; 2 accepted talks 11:45 am Lunch break 2:00 pm Session 8: Behavior III: Motor performance Invited speaker: John Krakauer; 2 accepted talks 3:45 pm Session 9: Reward: Learning and prediction Invited speaker: Yael Niv; 3 accepted talks 5:15 pm Dinner break 7:30 pm Poster Session III COSYNE 2014 i Sunday, 2 March 7:30 am Breakfast 8:30 am Session 10: Decision making Invited speakers: Anne Churchland, Joshua Gold; 2 accepted talks 11:00 am Session 11: Modulation: (Dis)Engaging sensory processing 4 accepted talks 12:00 pm Lunch break 2:00 pm Session 12: Perception Invited speaker: Doris Tsao; 2 accepted talks ii COSYNE 2014 Poster Session Topics Session I Session II Session III Thursday Friday Saturday Topic Area Optogenetics 1–5 Behavior 6–12 Neural encoding, decoding 13 1–31 Cognition 14–55 1–3 Computational, modeling 56–100 32–35 4–62 Other representations 36–39 Sensory systems 40–88 63–64 Techniques 89–100 Learning, plasticity 65–84 Motor systems 85–100 COSYNE 2014 iii Brain Corporation leverages neuroscience and machine learning towards a platform enabling robots who learn. Our software and algorithms add intelligence to robotics platforms allowing them to become teachable, much like animals. Brain Corporation partners with Qualcomm, leader in mobile technology. Robots who learn. Seeking Experts in Sensorimotor Control and Software Development A number of full-time positions at all levels are available immediately in theoretical and computational modeling of sensorimotor control at Brain Corporation, San Diego, CA. Submit your CV/resume, relevant papers, and source code samples to [email protected]. In your cover letter, please address at least two of the requirements below. Requirements: We are seeking candidates who are exceptional in one or more of the following areas: � Feed-forward and recurrent neural networks, spike-timing plasticity and dynamics. � Machine learning techniques, including convolutional net- works and deep learning. � Sensorimotor transformations, sensorimotor processing and reinforcement learning. Plus have hacker level ability in regards to programming: � Programming in two or more languages, including Python and C/C++/Objective-C. Competitive Compensation Packages The employee compensation package includes a stock option grant, matching 401k retirement contributions, medical, dental and vision insurance coverage, and annual performance bonuses. Employees have access to facilities on the Qualcomm campus and the offi ce is located in proximity to UCSD and the Salk Institute in San Diego, California. Please visit www.braincorporation.com for more information. Great companies never stop moving forward Qualcomm is a world leader in providing mobile communications, computing and network solutions that are transforming the way we live, learn, work, and play. As a pioneering technology innovator, we are committed to continuous evolution and exploration. Our researchers and computational neuroscientists engage in a wide variety of exciting and technically challenging projects—including the application of biologically inspired learning machines to a new breed of neuromorphic computing devices. We help you work smarter, move faster and reach further. We see success in your future. In fact, we’re passionate about it. We are futurists. www.qualcomm.com/research AdPAck_Consumer_science.indd 1 1/28/10 5:10 PM Record. Process. Stimulate. Store. Thousands of Channels Without Compromise. TDT delivers the industry’s most dependable and flexible research instrumentation. Our new High-Density Cortical Arrays offer precision signal capture, perfect for multichannel recording and stimulation. Achieve maximum real-time control, when pairing with TDT’s RZ2 Signal Processor. Optimize your research by building your arrays with TDT’s Online Cortical Array Designer. With configuration ranges from 16 to 400 channels, define each electrode length to customize to your exact needs. Pair your arrays with TDT’s PZ5 NeuroDigitizer. With the best signal-to-noise ratio and dynamic range of any amplifier available today, the PZ5 is an industry favorite for multichannel recordings. Acquire evoked potentials, EEG, EMG and analog signals - all with a single device. [email protected] | 386.462.9622 THE NEW VISUAL NEUROSCIENCES HUMAN ROBOTICS The MIT Press edited by John S. Werner and Neuromechanics and Motor Control Leo M. Chalupa Etienne Burdet, David W. Franklin, A comprehensive review of contem- and Theodore E. Milner porary research in the vision sciences, A synthesis of biomechanics and refl ecting the rapid advances of neural control that draws on recent recent years. advances in robotics to address 584 pp., 575 b&w illus., 281 color plates, $250 cloth control problems solved by the human sensorimotor system. NEUROSCIENCE 288 pp., 104 illus., $45 cloth A Historical Introduction Mitchell Glickstein THE COGNITIVEEMOTIONAL An introduction to the structure and BRAIN function of the nervous system that From Interactions to Integration emphasizes the history of experiments Luiz Pessoa and observations that led to modern A study that goes beyond the neuroscientifi c knowledge. debate over functional specialization 376 pp., 52 color illus., 119 b&w illus., $50 cloth to describe the ways that emotion and cognition interact and are BRAIN STRUCTURE AND integrated in the brain. ITS ORIGINS 336 pp., 70 b&w illus., 14 color plates, Function, Evolution, Development $40 cloth Gerald E. Schneider Visit the An introduction to the brain’s ana- MIT PRESS tomical organization and functions with BOOTH explanations in terms of evolutionary adaptations and development. for a 30% 656 pp., 243 color illus., 127 b&w illus., $75 cloth DISCOUNT The MIT Press mitpress.mit.edu NEURO-ELECTRONICS RESEARCH FLANDERS VISUAL PROCESSING DECISION MAKING LEARNING & MEMORY CHEMOSENSORY PROCESSING SENSORY INTEGRATION Also visit us during our annual NERF Neurotechnology Symposium on May 5th and 6th, 2014. The symposium focuses on novel technologies for studying neural circuits, brain machine interfacing and neuromorphics engineering. Confirmed speakers: Elisabetta Chicca, Universität Bielefeld, Germany Valentina Emiliani, INSERM, France Michele Giugliano, University of Antwerp, Belgium Andreas Hierlemann, ETH, Switzerland Adi Mizrahi, The Hebrew University of Jerusalem, Israel Arto Nurmikko, Brown University, USA Bernardo Sabatini, HHMI, USA Andreas Schaefer, NIMR, UK Ian Wickersham, MIT, USA Mehmet Fatih Yanik, MIT, USA We look forward to welcoming you at this exciting event ! NERF is a joint basic research initiative, set up by imec, VIB and KU Leuven to unravel the functioning of the brain. At the NERF labs, located in the heart of Europe in Leuven Belgium, world-class neuroscientists look into fundamental neuroscientific questions through collaborative, interdisciplinary research, combining nanoelectronics with neurobiology, physics, engineering and computer science. www.nerf.be connect to neural interface system neuroscience research neuroprosthetic development Mac OSX, Windows, Linux up to 512 electrodes amplifier front ends for electrodes amplify, lter, and digitize biopotential signals surf D 16-channel dierential pairs - EMG surf S 32-channel single reference - EEG, ECog, ENG micro 32-channel single reference - spikes and LFP micro 32-channel single reference, record and +stim stimulate - spikes and LFP nano rodent microelectrode applications low-cost laboratory processor option for scout up to 128 channels. Contact us for a demonstration in your lab. toll free (866) 324-5197 local (801) 413-0139 fax (801) 413-2874 ® email [email protected] © 2013 ripple LLC, patents pending Plexon is the pioneer and global leader in custom, high performance and comprehensive data acquisition and behavioral analysis solutions specifically designed for neuroscience research. ® D OmniPlex Data Acquisition Extensive online spike sorting 16 - 256 channels with DigiAmp™ ™ Real-time low latency performance ® Ultrafast file loading with PL2™ PlexBright CinePlex Optogenetics Behavioral Research Industry leading LED intensities Stand-alone CinePlex Lite, or LED/Laser driver with pattern generation Full integration with Neural Recording Ultra high performance
Recommended publications
  • The Creation of Neuroscience
    The Creation of Neuroscience The Society for Neuroscience and the Quest for Disciplinary Unity 1969-1995 Introduction rom the molecular biology of a single neuron to the breathtakingly complex circuitry of the entire human nervous system, our understanding of the brain and how it works has undergone radical F changes over the past century. These advances have brought us tantalizingly closer to genu- inely mechanistic and scientifically rigorous explanations of how the brain’s roughly 100 billion neurons, interacting through trillions of synaptic connections, function both as single units and as larger ensem- bles. The professional field of neuroscience, in keeping pace with these important scientific develop- ments, has dramatically reshaped the organization of biological sciences across the globe over the last 50 years. Much like physics during its dominant era in the 1950s and 1960s, neuroscience has become the leading scientific discipline with regard to funding, numbers of scientists, and numbers of trainees. Furthermore, neuroscience as fact, explanation, and myth has just as dramatically redrawn our cultural landscape and redefined how Western popular culture understands who we are as individuals. In the 1950s, especially in the United States, Freud and his successors stood at the center of all cultural expla- nations for psychological suffering. In the new millennium, we perceive such suffering as erupting no longer from a repressed unconscious but, instead, from a pathophysiology rooted in and caused by brain abnormalities and dysfunctions. Indeed, the normal as well as the pathological have become thoroughly neurobiological in the last several decades. In the process, entirely new vistas have opened up in fields ranging from neuroeconomics and neurophilosophy to consumer products, as exemplified by an entire line of soft drinks advertised as offering “neuro” benefits.
    [Show full text]
  • Ricardo Mallarino Howard Hughes Medical Institute
    Ricardo Mallarino Howard Hughes Medical Institute; Department of Organismic & Evolutionary Biology and Department of Molecular & Cellular Biology, Harvard University, 26 Oxford Street, Cambridge, MA Phone (617)-308-5895; email: [email protected] EDUCATION 2011-present Postdoctoral Fellow, Hopi Hoekstra Laboratory, Harvard University, Cambridge, MA 2005-2011 Ph.D., Biology, Arhat Abzhanov Laboratory, Harvard University, Cambridge, MA 1998-2003 B.S., Biology, Universidad de los Andes, Bogotá, Colombia RESEARCH INTERESTS Molecular basis of morphological change; developmental biology; ecology and evolutionary biology; genetics and genomics. RESEARCH EXPERIENCE 2011-present Department of Organismic & Evolutionary Biology and Department of Molecular & Cellular Biology, Hopi Hoekstra laboratory -Studied the molecular basis of local adaptation in Peromyscus mice using functional in vivo and in vitro approaches -Developed a new mammalian model species for studying the developmental basis of periodic pattern formation 2005-2011 Department of Organismic & Evolutionary Biology, Arhat Abzhanov laboratory -Identified a network of developmental genes responsible for generating beak diversity in Darwin’s finches -Studied beak patterning mechanisms in the relatives of Darwin’s finches 2005 Whitehead Institute, Susan Lindquist laboratory -Studied the role of molecular chaperones in controlling adaptive polyphenisms in insects 2003-2005 Smithsonian Tropical Research Institute, supervisors: Chris Jiggins and Biff Bermingham -Studied molecular systematics and phylogenetics of tropical butterflies 2001-2003 Smithsonian Tropical Research Institute, supervisor: Penelope Barnes -Studied coevolution of marine bivalves of the Family Lucinidae and their sulfur-oxidizing bacterial endosymbionts RESEARCH GRANTS AND AWARDS 2012 Putnam Expeditionary Grant; Harvard University 2009 Doctoral Dissertation Improvement Grant, National Science Foundation 2008 Summer Research Grant, Rockefeller Center for Latin American Studies, Harvard University 2005 Student Research Award, Dept.
    [Show full text]
  • Section 1: MIT Facts and History
    1 MIT Facts and History Economic Information 9 Technology Licensing Office 9 People 9 Students 10 Undergraduate Students 11 Graduate Students 12 Degrees 13 Alumni 13 Postdoctoral Appointments 14 Faculty and Staff 15 Awards and Honors of Current Faculty and Staff 16 Awards Highlights 17 Fields of Study 18 Research Laboratories, Centers, and Programs 19 Academic and Research Affiliations 20 Education Highlights 23 Research Highlights 26 7 MIT Facts and History The Massachusetts Institute of Technology is one nologies for artificial limbs, and the magnetic core of the world’s preeminent research universities, memory that enabled the development of digital dedicated to advancing knowledge and educating computers. Exciting areas of research and education students in science, technology, and other areas of today include neuroscience and the study of the scholarship that will best serve the nation and the brain and mind, bioengineering, energy, the envi- world. It is known for rigorous academic programs, ronment and sustainable development, informa- cutting-edge research, a diverse campus commu- tion sciences and technology, new media, financial nity, and its long-standing commitment to working technology, and entrepreneurship. with the public and private sectors to bring new knowledge to bear on the world’s great challenges. University research is one of the mainsprings of growth in an economy that is increasingly defined William Barton Rogers, the Institute’s founding pres- by technology. A study released in February 2009 ident, believed that education should be both broad by the Kauffman Foundation estimates that MIT and useful, enabling students to participate in “the graduates had founded 25,800 active companies.
    [Show full text]
  • Sten Grillner
    BK-SFN-HON_V9-160105-Grillner.indd 108 5/6/2016 4:11:20 PM Sten Grillner BORN: Stockholm, Sweden June 14, 1941 EDUCATION: University of Göteborg, Sweden, Med. Candidate (1962) University of Göteborg, Sweden, Dr. of Medicine, PhD (1969) Academy of Science, Moscow, Visiting Scientist (1971) APPOINTMENTS: Docent in Physiology, Medical Faculty, University of Göteborg (1969–1975) Professor, Department of Physiology III, Karolinska Institute (1975–1986) Director, Nobel Institute for Neurophysiology, Karolinska Institute, Professor (1987) Nobel Committee for Physiology or Medicine, Chair, 1995–1997 (1987–1998) Nobel Assembly at the Karolinska Institutet, Member Chair, 2005 (1988–2008) Chairman Department of Neuroscience, Karolinska Institutet (1993–2000) Distinguished Professor, Karolinska Institutet (2010) HONORS AND AWARDS: Member of Academiae Europaea 1990– Member of Royal Swedish Academy of Science 1993– Chairman Section for Biology and Member of Academy Board, 2004–2010 Member of Norwegian Academy of Science and Letters, 1997– Member American Academy of Arts and Sciences, 2004– Honorary Member of the Spanish Medical Academy, 2006– Foreign Associate of Institute of Medicine of the National Academy, United States, 2006– Foreign Associate of the National Academy, United States, 2010– Associate of the Neuroscience Institute, La Jolla, 1989– Member EMBO, 2014– Florman Award, Royal Swedish Academy of Science, 1977 Grass Lecturer to the Society of Neuroscience, Boston, 1983 Greater Nordic Prize of Eric Fernstrom, Lund, Sweden, 1990 Bristol-Myers
    [Show full text]
  • Neural Construction of Conscious Perception
    Neural construction of conscious perception Thesis by Janis Karan Hesse In Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy CALIFORNIA INSTITUTE OF TECHNOLOGY Pasadena, California 2020 (Defended May 28th, 2020) ii 2020 Janis Hesse ORCID: 0000-0003-0405-8632 iii ACKNOWLEDGEMENTS I'd like to thank Doris Tsao for being an incredible advisor and undepletable source of ideas, advice and inspiration, for sharing her passion for science with me, and giving me the courage to ask big questions. I am very happy about the choice of my thesis committee. Markus Meister, Ueli Rutishauser, and Ralph Adolphs contributed substantially by providing useful ideas, discussions, and criticisms throughout this thesis. I want to thank current and past members of the Tsao lab, including Varun Wadia, Nicole Schweers, Audo Flores, Pinglei Bao, Liang She, Steven Le Chang, Xueqi Cheng Shay Ohayon, Tomo Sato, Joseph Wekselblatt, Francisco Luongo, Lu Liu, Anne Martin, Jessa Alexander, Erin Koch, Jialiang Lu, Yuelin Shi, Alex Farhang, Irene Caprara, Frank Lanfranchi, Lindsay Salay, Hongsun Guo, Abriana Sustaita, and Sebastian Moeller, who have all been very willing to offer me help whenever I needed, taught me the different techniques in the lab, and gave me great comments, ideas and discussions. I would also like to note that the work on human epilepsy patients described in Chapter VI is as much of Varun Wadia's work as it is mine. I am grateful to have started my PhD with such a lovely cohort. My PhD would not have been as fun without Mason McGill, Vineet Augustine, Gabriela Tavares, and Ryan Cho.
    [Show full text]
  • The US BRAIN Initiative
    The US BRAIN Initiative Brain Research through Advancing Innovative Neurotechnologies John Donoghue, Ph.D. member US BRAIN Geneva Professor Advisory Commi5ee to the NIH Director of Neuroscience Director 1 views expressed here are my own and not those of the US Government Why a US BRAIN Initiative? The Need Is Great § Brain disorders: #1 source of disability in U.S. – > 100 million Americans affected § Rates are increasing § Costs are increasing- § annual cost of dementia ~$200B § by 2050 >$1Trillion § Already equals cost of cancer and heart disease The cost of disorders of the brain in Europe amounts overall to €798 billion in 2010 Eur Neuropsych. (2011) 21, 817-779 WHO, 2008 The Challenge for the 21st Century We do NOT know enough about the brain source: Donoghue! 3 “The Next Great American Project” “So there is this enormous mystery waiPng to be unlocked, and the BRAIN IniPave will change that by giving sciensts the tools they need to get a dynamic picture of the brain in acCon and be5er understand how we think and how we learn and how we remember. And that knowledge could be – will be – transformave.” -- President Obama, April 2, 2013 4 US BRAIN Initiative “a public and private effort” + Private Investments 5 The NIH BRAIN ScienCfic Plan • NIH Advisory Committee to the Director- William Newsome, PhD (co-chair) Working Group Stanford University (scientists, federal officials) • Met 2013-14 • Broad input from Cornelia Bargmann, PhD scientific community (co-chair) The Rockefeller University • Released June 2014 FIRST FIVE YEARS SECOND FIVE YEARS Emphasize technology Emphasize discovery development driven science 6 Understanding the Brain as a SYSTEM To map the circuits of the brain, measure the fluctuang paerns of electrical and chemical acPvity flowing within those circuits, and understand how their interplay creates our unique cogniPve and behavioral capabiliPes.
    [Show full text]
  • Cold Spring Harbor Symposia on Quantitative Biology, Volume LXXIX: Cognition
    This is a free sample of content from Cold Spring Harbor Symposia on Quantitative Biology, Volume LXXIX: Cognition. Click here for more information on how to buy the book. COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME LXXIX Cognition symposium.cshlp.org Symposium organizers and Proceedings editors: Cori Bargmann (The Rockefeller University), Daphne Bavelier (University of Geneva, Switzerland, and University of Rochester), Terrence Sejnowski (The Salk Institute for Biological Studies), and David Stewart and Bruce Stillman (Cold Spring Harbor Laboratory) COLD SPRING HARBOR LABORATORY PRESS 2014 © 2014 by Cold Spring Harbor Laboratory Press. All rights reserved. This is a free sample of content from Cold Spring Harbor Symposia on Quantitative Biology, Volume LXXIX: Cognition. Click here for more information on how to buy the book. COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME LXXIX # 2014 by Cold Spring Harbor Laboratory Press International Standard Book Number 978-1-621821-26-7 (cloth) International Standard Book Number 978-1-621821-27-4 (paper) International Standard Serial Number 0091-7451 Library of Congress Catalog Card Number 34-8174 Printed in the United States of America All rights reserved COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY Founded in 1933 by REGINALD G. HARRIS Director of the Biological Laboratory 1924 to 1936 Previous Symposia Volumes I (1933) Surface Phenomena XXXIX (1974) Tumor Viruses II (1934) Aspects of Growth XL (1975) The Synapse III (1935) Photochemical Reactions XLI (1976) Origins
    [Show full text]
  • 2010 Buenos Aires, Argentina
    Claiming CME Credit To claim CME credit for your participation in the MDS 14th Credit Designation International Congress of Parkinson’s Disease and Movement The Movement Disorder Society designates this educational Disorders, International Congress participants must complete activity for a maximum of 35 AMA PRA Category 1 Credits™. and submit an online CME Request Form. This form will be Physicians should only claim credit commensurate with the available beginning June 15. extent of their participation in the activity. Instructions for claiming credit: If you need a Non-CME Certificate of Attendance, please tear • After June 15, visit the MDS Web site. out the Certificate in the back of this Program and write in • Log in after reading the instructions on the page. You will your name. need your International Congress File Number which is located on your name badge or e-mail The Movement Disorder Society has sought accreditation from [email protected]. the European Accreditation Council for Continuing Medical • Follow the on-screen instructions to claim CME Credit for Education (EACCME) to provide CME activity for medical the sessions you attended. specialists. The EACCME is an institution of the European • You may print your certificate from your home or office, or Union of Medical Specialists (UEMS). For more information, save it as a PDF for your records. visit the Web site: www.uems.net. Continuing Medical Education EACCME credits are recognized by the American Medical The Movement Disorder Society is accredited by the Association towards the Physician’s Recognition Award (PRA). Accreditation Council for Continuing Medical Education To convert EACCME credit to AMA PRA category 1 credit, (ACCME) to provide continuing medical education for contact the AMA online at www.ama-assn.org.
    [Show full text]
  • Reviewers [PDF]
    The Journal of Neuroscience, January 2013, 33(1) Acknowledgement For Reviewers 2012 The Editors depend heavily on outside reviewers in forming opinions about papers submitted to the Journal and would like to formally thank the following individuals for their help during the past year. Kjersti Aagaard Frederic Ambroggi Craig Atencio Izhar Bar-Gad Esther Aarts Céline Amiez Coleen Atkins Jose Bargas Michelle Aarts Bagrat Amirikian Lauren Atlas Steven Barger Lawrence Abbott Nurith Amitai David Attwell Cornelia Bargmann Brandon Abbs Yael Amitai Etienne Audinat Michael Barish Keiko Abe Martine Ammasari-Teule Anthony Auger Philip Barker Nobuhito Abe Katrin Amunts Vanessa Auld Neal Barmack Ted Abel Costas Anastassiou Jesús Avila Gilad Barnea Ute Abraham Beau Ances Karen Avraham Carol Barnes Wickliffe Abraham Richard Andersen Gautam Awatramani Steven Barnes Andrey Abramov Søren Andersen Edward Awh Sue Barnett Hermann Ackermann Adam Anderson Cenk Ayata Michael Barnett-Cowan David Adams Anne Anderson Anthony Azevedo Kevin Barnham Nii Addy Clare Anderson Rony Azouz Scott Barnham Arash Afraz Lucy Anderson Hiroko Baba Colin J. Barnstable Ariel Agmon Matthew Anderson Luiz Baccalá Scott Barnum Adan Aguirre Susan Anderson Stephen Baccus Ralf Baron Geoffrey Aguirre Anuska Andjelkovic Stephen A. Back Pascal Barone Ehud Ahissar Rodrigo Andrade Lars Bäckman Maureen Barr Alaa Ahmed Ole Andreassen Aldo Badiani Luis Barros James Aimone Michael Andres David Badre Andreas Bartels Cheryl Aine Michael Andresen Wolfgang Baehr David Bartés-Fas Michael Aitken Stephen Andrews Mathias Bähr Alison Barth Elias Aizenman Thomas Andrillon Bahador Bahrami Markus Barth Katerina Akassoglou Victor Anggono Richard Baines Simon Barthelme Schahram Akbarian Fabrice Ango Jaideep Bains Edward Bartlett Colin Akerman María Cecilia Angulo Wyeth Bair Timothy Bartness Huda Akil Laurent Aniksztejn Victoria Bajo-Lorenzana Marisa Bartolomei Michael Akins Lucio Annunziato David Baker Marlene Bartos Emre Aksay Daniel Ansari Harriet Baker Jason Bartz Kaat Alaerts Mark S.
    [Show full text]
  • Making Your Mind: Molecules, Motion, and Memory Lecture One – Mapping Memory in the Brain Eric R
    Making Your Mind: Molecules, Motion, and Memory Lecture One – Mapping Memory in the Brain Eric R. Kandel, M.D. 1. Start of Lecture I (0:15) [ANNOUNCER:] From the Howard Hughes Medical Institute. The 2008 Holiday Lectures on Science. This year's lectures, "Making Your Mind: Molecules, Motion, and Memory," will be given by Dr. Eric Kandel, Howard Hughes Medical Institute investigator at Columbia University, and Dr. Thomas Jessell, Howard Hughes Medical Institute investigator also at Columbia University. The first lecture is titled "Mapping Memory in the Brain." And now to introduce our program, the President of the Howard Hughes Medical Institute, Dr. Thomas Cech. 2. Welcome by HHMI President Dr. Thomas Cech (1:08) [DR. CECH] Welcome to the Howard Hughes Medical Institute and the 2008 Holiday Lectures on Science. The Institute initiated this series in 1993. In 1995 I had the pleasure of coming here and delivering the lectures on catalytic RNA, and since I've been President of the Institute it's been a great pleasure to be involved in choosing 18 terrific scientists to talk to students here in the auditorium. The Holiday Lectures are one of more than 30 research and education programs of the Institute and please visit our website www.hhmi.org to learn more about all of our activities. This lecture series focuses on the most complex organ in our body and arguably the one that most is responsible for making us human. Clearly without this organ you wouldn't be able to find this auditorium, and even if you got here you wouldn't understand a word that was being said.
    [Show full text]
  • 3 and 4/1998 Genetic Engineering and Biotechnology
    OCCASION This publication has been made available to the public on the occasion of the 50th anniversary of the United Nations Industrial Development Organisation. DISCLAIMER This document has been produced without formal United Nations editing. The designations employed and the presentation of the material in this document do not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations Industrial Development Organization (UNIDO) concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries, or its economic system or degree of development. Designations such as “developed”, “industrialized” and “developing” are intended for statistical convenience and do not necessarily express a judgment about the stage reached by a particular country or area in the development process. Mention of firm names or commercial products does not constitute an endorsement by UNIDO. FAIR USE POLICY Any part of this publication may be quoted and referenced for educational and research purposes without additional permission from UNIDO. However, those who make use of quoting and referencing this publication are requested to follow the Fair Use Policy of giving due credit to UNIDO. CONTACT Please contact [email protected] for further information concerning UNIDO publications. For more information about UNIDO, please visit us at www.unido.org UNITED NATIONS INDUSTRIAL DEVELOPMENT ORGANIZATION Vienna International Centre, P.O. Box 300, 1400 Vienna, Austria Tel: (+43-1) 26026-0 · www.unido.org · [email protected] EMERGING TECHNOLOGY SERIES 3 and 4/1998 Genetic Engineering and Biotechnology UNITED NATIONS INDUSTRIAL DEVELOPMENT ORGANIZATION Vienna, 1999 TO OUR READERS EMERGING TECHNOLOGY SERIES: Globalization, the information society, sustainable development: these are the keywords of the day.
    [Show full text]
  • Dynamic Compression and Expansion in a Classifying Recurrent Network
    bioRxiv preprint doi: https://doi.org/10.1101/564476; this version posted March 1, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Dynamic compression and expansion in a classifying recurrent network Matthew Farrell1-2, Stefano Recanatesi1, Guillaume Lajoie3-4, and Eric Shea-Brown1-2 1Computational Neuroscience Center, University of Washington 2Department of Applied Mathematics, University of Washington 3Mila|Qu´ebec AI Institute 4Dept. of Mathematics and Statistics, Universit´ede Montr´eal Abstract Recordings of neural circuits in the brain reveal extraordinary dynamical richness and high variability. At the same time, dimensionality reduction techniques generally uncover low- dimensional structures underlying these dynamics when tasks are performed. In general, it is still an open question what determines the dimensionality of activity in neural circuits, and what the functional role of this dimensionality in task learning is. In this work we probe these issues using a recurrent artificial neural network (RNN) model trained by stochastic gradient descent to discriminate inputs. The RNN family of models has recently shown promise in reveal- ing principles behind brain function. Through simulations and mathematical analysis, we show how the dimensionality of RNN activity depends on the task parameters and evolves over time and over stages of learning. We find that common solutions produced by the network naturally compress dimensionality, while variability-inducing chaos can expand it. We show how chaotic networks balance these two factors to solve the discrimination task with high accuracy and good generalization properties.
    [Show full text]