08/09 VICTOR CHANG CARDIAC RESEARCH INSTITUTE REVIEW
“BIOMEDICAL RESEARCH IS A GLOBAL ENTERPRISE INVOLVING A NETWORKK OF WORLDWIDELD COLLABORATIONS” HEART FACTS Mission statement & CONTENTS
Mary Aikenhead Ministries • • • • • • Chair: Mr. Richard Harpham
St. Vincent’s Health The relief of pain and suffering and Australia Ltd CEO: Dr. Tracey Batten JOURNEY OF THE BLOOD Cardiovascular Disease prevalence in Australians the promotion of well-being, through an understanding of the fundamental St. Vincent's & mechanisms of cardiovascular biology Mater Health in health and disease. CEO: Mr. Steven Rubic
victor chang cardiac TO LUNGS AND BACK TO THE HEART THREE POINT SEVEN MILLION research institute Introduction — 00 Overview 00 Chairman's Report VCCRI University of NSW 00 DIRECTOR's Report Vice Chancellor: Professor Fred Hilmer, AO 00 Victor Chang organisational FIRST SINGLE LUNG TRANSPLANT FIRST BILATERAL LUNG TRANSPLANT HEART BEATS SEVENTY TIMES PER MINUTE people WAITING for HEART TRANSPLANTS 00 Vale 00 The Institute structure 00 15 Years of Discovery Board Chairman Mr. Steven Lowy, AM Board Committees — 00 Board Members Committees 00 Committees Executive Management scientific advisory Mr. Steven Lowy Research programs commitee Finance 1990 1992 3,000 — Mr. John Kean 3,700,000 00 C ardiac Physiology and Appeals Transplantation Mr. John McGuigan NUMBER OF AUSTRALIAN WOMEN WHO DIED FROM CORONARY HEART DISEASE IN 2000 HEART FAILURE DEATHS HIGHER IN WOMEN heart DISEASE DOESN'T DISCRIMINATE a heart is viable outside the body HEART CONTRACTIONS PER DAY 00 Developmental Biology 00 Molecular Cardiology and Biophysics 00 Molecular Genetics Executive Director 00 Structural and Professor Robert STRIKES THE Graham, AO Computational Biology AWARDS AND SEMINARS Chief Operating Officer — Research Divisions YOUNG AND OLD 00 VCCRI Awardees UP 4HRS 100,000 00 Awards and Achievements 00 Seminar Series LIFE EXPECTANCY OF MEN FIRST ORGAN TO BEGIN FUNCTIONING PEOPLE WHO DIE OF (CVD) IN AUSTRALIA Ml’s OF BLOOD PUMPED EACH BEAT 00 Symposium/Princesses Lecture 00 Publications 08/09 Administrative Support Administration Report — 00 Finance REPORT Core Facilities Essential Services 00 Vccri Spotlight 00 Fundrasing and Functions 00 School Science Awards 76.6 HEART 1IN3 70-100 00 Limited Members 00 VCCRI Supporters 12,469 1_The VCCRI Annual Report 08/09 OVERVIEW
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International — 8_Canada 13_Wales 16 8 17 – Howard Hughes Institute – Cardiff University 10 – Samuel Lunenfeld Research 13 14 20 22 Institute 14_Denmark Our Institutions 12 – Royal Danish Academy 11 9_USA of Sciences & Letters 9 16 – Harvard Medical School, Boston 15_Japan 26 18 – Harvard Stem Cell Institute, Boston 15 – Cardiovascular Research Institute, – Osaka University 19 San Francisco – RIKEN, Saitama – University of San Francisco – Cincinnati Children’s Hospital 16_Sweden Medical Centre 25 – University of Virginia – Karolinksa Institute, Stockholm – University of Minnesota 24 – University of Wisconsin 17_UK – Mayo Clinic, Rochester – University of Oxford, England – Vanderbilt University, Tennessee – Royal Devon & Exeter Hospital, – University of Phoenix, Arizona The Worldwide Web Exeter – Case Western Reserve University, – University of Liverpool 23 Cleveland of Heart Research – Addenbrooke’s Hospital, Cambridge – Northwestern University, Chicago – University of Cambridge — – University of Chicago, Chicago – University of Oxford – Emory University School of – Imperial College of London More than ever before, science Medicine, Atlanta – Royal Brompton Hospital, London – Children’s Hospital Oakland progresses as an open-ended – University of Newcastle Upon Tyne Research Institute, California network of human activity. – Sanger Centre, Great Britain – Stanford University, California 5 – Royal College of Surgeons, Ireland The private curiosity, drive, insight 6 – UC San Diego, California 7 1 – Burnham Institute for Medical and even genius of individual 4 3 18_Korea 2 Research, La Jolla scientists are still at the core of – UMDNJ-New Jersey Medical – Yonsei University College this activity. However, the ability Virtually overnight, we moved from 21 School, Newark of Medicine, Seoul to communicate freely through an ability to analyse single genes at – Rochester University, NY – Cold Spring Harbour 19_China email and other electronic means, a time, extrapolating wildly about Laboratories, NY – Zensun Ltd, Shanghai and through the worldwide web to the behaviour of the whole cell, to The Victor Chang Cardiac Local – University of Illinois Urbana- one in which we can interrogate Research Institute is committed Champaign 20_Switzerland access virtually all of the published — – UTMB, Galveston, Texas literature as well as websites hosting all of the 40,000 or so genes in to making important discoveries 1_ Sydney 4_Melbourne – University of Texas – University of Geneva the human genome in a single in cardiovascular biology and – Louisiana State University Health large data sets, has revolutionised 21_New Zealand medicine. Its scientists are – Victor Chang Cardiac – St. Vincent’s Institute Sciences Centre the way science is conducted. Ideas experiment. Robots have also allowed Research Institute – Walter & Eliza Hall Institute – Chori, USA us to do hundreds of thousands of very much embedded in the – Centenary Institute – Monash University – CSHL, USA – Starship Hospital, Auckland now circulate more freely instead of – University of Auckland manipulations that a singe researcher worldwide web of heart research. – Garvan Institute – Peter MacCallum Cancer Centre – University of Birmingham, Alabama being buried away in obscure books – St. Vincent’s Hospital – Baker IDI – University of Otago, Dunedin could not possibly contemplate. They collaborate widely with – Mesoblast Ltd 10_ Netherlands and journals, and can be seized upon, – Children’s Hospital & Medical 22_Poland Research Institute – University of Melbourne filtered and extended very rapidly The data sets we generate are huge, researchers internationally, and these – University of Amsterdam – Bosch Institute – Royal Melbourne Hospital – Warsaw University by others, much in the same way and there is a strong expectation in collaborations lead to important – Donate Life, Liverpool Hospital – Alfred Hospital – Academic Medical Centre, the community that these be made discoveries, as can be seen by the – Macquarie University Amsterdam 23_ Singapore as cultural ideas and trends pervade 5_Brisbane – VIB, Netherlands publicly available for other scientists high impact of our publications. – Millenium Institute, Westmead the community. Adding to this, the – Sydney Melanoma Unit – Nanyang University – Mater Medical Research Institute 1 1 _ F r a n c e to analyse. As a result, a new This impact is as much related to – University of Sydney technology of experimental science – IMB, University of Queensland 2 4 _ I n d i a – Prince of Wales Medical generation of scientists skilled how those discoveries pervade back – Queensland Institute for Medical – Pasteur Institute, Paris has changed dramatically. Research Institute Research – University of Nice, Sophia-Antipolis – Centre for Cellular & Molecular The scale of our endeavours, aided in information technology who help through the worldwide information – Children's Hospital Westmead – Griffith University Biology, Hyderabad by computers, is simply mind- us sift through these large data sets network and are used by others, – University of New South Wales 12_Germany for their hidden secrets, has emerged. as the discoveries themselves. – EngeneIC Ltd 6_Perth 25_Hong Kong boggling. Genes provide the heritable – BMI, Sydney – Institute of Molecular Biology, code for proteins and RNA, which are Because of the need for a greater These are exciting times, and the – WA Institute of Medical Research Hanover – University of Hong Kong 2_Wollongong – University of Western Australia – Karlsruhe Institute of Technology, range of expertise and technologies, brief profiles and stories provided 26_Italy the enzymes and structural elements – Curtin University Karlsruhe collaborations between laboratories in this VCCRI Annual Report speak – University of Wollongong – University of Cologne, Koeln that make up the cells of our bodies. – EMBL, Montorotondo and the sharing of reagents are now not only of the individuals and their 7_Adelaide – University of Heidelberg Accidental changes in genes or how 3_Canberra – EMBL vital parts of our work. Science is achievements, but also of the web- – Hanson Institute they are regulated cause disease, – Australian National University – Max Planck Institute – University of Adelaide conducted as a human network like organism of science and how it – John Curtin School of Medicine – Medical University, Berlin or contribute to the severity of – IVMS, Adelaide disease, including heart disease. spread across the globe. impacts our daily lives. – University of South Australia
2_The VCCRI Annual Report 08/09 3_The VCCRI Annual Report 08/09 Chairman’s Report
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During our 15th year, the Institute was Ladies and gentlemen, each of the past Fundraising and functions Our inaugural Victor Chang Young Board and Appeals Committee able to reflect on how far it has come. 15 years has been marked by at least Without VCCRI friends and supporters Ambassador Award was presented to In these times of global financial It has established an international one major discovery in a wide-ranging our institute would not exist. Despite Mark Vincent for his continuing support uncertainty, the VCCRI is guided by reputation in understanding the heart and area of heart disease biology. These the difficult economic conditions of the of the Institute. As many of you would a talented leadership team that the mechanisms that make it work. Each discoveries range from studies showing past two years donors continued to give know Mark is the grandson of the late ensures our continued research member of our faculty is recognised the benefits of lowering cholesterol to generously thanks to the efforts of the Bruno Riccio, is a staunch supporter success and I acknowledge their worldwide for their work and it is studies that explain how the severity Board and Appeals Committee. of the Institute and won the 2009 important contributions. Two board because of them that the Institute has of a disease can differ even between Australia’s Got Talent competition. members, Mrs Roslyn Packer AO and been able to be recognised as one of the identical twins. Our researchers have Our fundraising events have been Professor Ian Dawes, retired after many world’s leading research institutes. discovered that diseases can by caused more successful than ever. This year Finances years of invaluable service. I thank them the Pall Mall Manufacturing Company, In fact, I’m very pleased to report that the by a defect in the activity of a gene Our financial position today remains sincerely for their outstanding efforts. and the Schwartz Foundation in Mr. Steven Lowy 5-yearly review of the Institute conducted rather than in its structure – part of a sustainable. Given the increased costs partnership with the Mercure, Sydney, I’d like to formally welcome in this forum AM (Chairman) by our Scientific Advisory Board has been new field called epigenetics. associated with our first full year in launched new fundraising programs two new board members, Angelos completed very recently and has borne the new building we had budgeted — We have had breakthroughs in on behalf of the VCCRI. Frangopoulos, and Gary Weiss, both of out this assessment of the standing of for a deficit in 2009 of some $[1.96] understanding the cause of heart whom bring tremendous experience The Victor Chang Cardiac Research the Institute. As you might know, the million. I’m pleased however to say we defects in babies and finding that In August 2009, more than 760 people and enthusiasm to the board. Institute remains a powerful symbol Advisory Board is made up of six of the mouse hearts can regenerate. We attended the annual Heart to Heart completed the year with a small profit of how one person can make an world’s most eminent scientists. have developed a new treatment that Ball in support of heart research and of $[92,000], ahead of budget I also thank the Sisters of Charity by approximately $2.1 million. extraordinary impact on the lives We will provide a very detailed account more than doubles the time a heart can heard a landmark speech from James through the Mary Aikenhead of many. of the Scientific Advisory Board’s review remain healthy after being removed Packer about the enormous challenge In 2009 our researchers attracted a Ministries for their continued of finding new and better ways to fund support and guidance. When he was alive, heart transplant later, but I would like to quote just a from a donor and before transplantation record $10.6 million in grant income from medical research. surgeon Dr Victor Chang spoke of his few preliminary words from its initial into a heart failure recipient. This is the NHMRC, Australian Research Council an enormously important advance, Conclusion vision for a research centre dedicated findings. It found that, quote: A wide range of other fundraising and and other peer-reviewed funding bodies. especially in Australia where large to eradicating heart disease. promotional activities were held during As expected in the prevailing economic Strong supporters are at the heart of “Under the leadership of Professor distances limit the availability of the year, from the Miedecke Motorsport climate, grants from private funding our institute. Without their generosity, He recognised that heart disease was Graham the Institute has developed to be hearts to a region within four hours promotion at the Targa Tasmania bodies fell but the amount of NHMRC your generosity, support and the worst health epidemic we face. one of the best-known and most highly- travelling time. Indeed, this advance race, to the Club Marconi charity ball, grants awarded to the VCCRI increased encouragement we would not have Each day 70 Australians die of heart respected medical research institutes has worldwide ramifications where the Steve Quinn’s cycling marathon from by 20% over the previous year. achieved these outstanding results disease Heart and circulatory diseases in Australia and has an international same limitations apply and often means Melbourne to Sydney as well as our and on behalf of the team at the Victor kill one Australian every 11 minutes. reputation for its cardiac research. that a patient with heart failure dies Total income for the Institute was up traditional golf days. Chang Cardiac Research Institute, More children die of heart disease than “The Victor Chang Institute has before they can get a suitably matched from $16.1 million to $[17.2] million I extend our heartfelt thanks. all other childhood diseases combined. survived, indeed thrived, through the donor heart. and we have cash and investments Awards and Honours We look forward to sharing the next 15 global financial crisis and has managed of approximately $[22] million. After Dr Victor Chang’s tragic death in In a recent landmark study our I am delighted to report that our years with you to bridge the gap between a complex building and relocation 1991 a concerted effort by dedicated researchers identified a gene which can executive director, Professor Robert This is a very good result, but we hope and cure. I believe that with your program, recently moving into the Lowy individuals, including Mr Kerry Packer lead to permanent kidney damage when Graham, was awarded an Order of continue to face some very real help, we can go a long way towards Packer Building which provides world- AC, together with donations from the there are not enough nutrients provided Australia, an AO, in the 2009 year’s funding challenges going forward. making the Victor Chang’s vision – the class facilities.” Commonwealth Government and the to a baby in the womb – another major Queen’s Birthday Honours list, and I Our fundraising challenge means it will eradication of heart disease – a reality. public, helped begin to turn Victor’s In summary, it found that, and again discovery given that kidney disease might say that few awards have been be important for the Institute to go on Thank you. vision into a reality. I quote: often leads to high blood pressure and so richly deserved. promoting its work to the public and heart failure. The Victor Chang Cardiac Research “The Victor Chang Institute has The 2009 Life Governor Award was explaining its importance. Institute was launched on February 15, developed admirably and is at the most All of these breakthroughs, and many presented to Mrs Roslyn Packer, AO. The board remains committed to this 1994, with relatively modest resources exciting point in its 15-year journey. more, are detailed in the published work All of us here are familiar with the objective and will think creatively in There is a realisation among the and operating from the old St Vincent’s of the Institute which is one of the most enormous contribution Ros has made the years ahead about how to broaden leadership, strongly endorsed by the Hospital medical students’ quarters. important measures of our success. over the entire life of the Institute, the funding base and build sustainable Scientific Advisory Board, that this is the Since last year, our researchers have personally and financially, and she is Temporary facilities were later opened income streams for the future. right time to take a deep breath and plan published 128 research papers in highly deservedly regarded as one of the by the late Diana, Princess of Wales, in strategically for the next phase of the regarded journals around the world, principal driving forces and reasons the Garvan Building and, finally, in 2008 Institute’s development.” as well as 8 book chapters. This is just for our success. the Lowy Packer Building, a state-of- one indicator of the incredible output the-art facility dedicated almost entirely I don’t think we could hope for a Tony Campologno OAM from Club more powerful endorsement of the generated by our team. to heart research, was opened by HRH Marconi, Chum Darvall of Deutsche Steven Lowy, AM Crown Princess Mary of Denmark. work we are all undertaking here, Bank, Martha Kennedy from LK Chairman, VCCRI Board of Directors and it gives Bob and his team great Jewellery and Cameron Irving were encouragement for the future. all appointed as Ambassadors.
4_The VCCRI Annual Report 08/09 5_The VCCRI Annual Report 08/09 director’s Report
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Other happenings Community activities Thanks For the past year I have held the The VCCRI now has 100 schools It would not be possible to conduct presidency of the Association participating in its School Science our important research without the of Australian Medical Research Awards program and will expand into generous support of our Friends – the Institutes, the peak lobby group the Illawarra and South East Region many people who give so generously for independent institutes including in the near future. The program was to support our work. This year, for the VCCRI. Modern medicine is developed to foster and encourage an example, we unveiled our new founded on scientific discoveries. interest in science among secondary confocal microscope, which was Professor. Robert M. Graham I am working to ensure that scientists school students, with the view to made possible by a generous bequest AO, FAA, MBBS (Hons), MD, have a strong voice in improving our promoting careers in science and from the estate of the late Herbert FRACP, FACP, FAHA health care system to ensure that biomedical research. This year’s Sydney Smith. This vital piece of — research into heart disease, cancer, winners came from schools in the equipment allows our researchers to and other major diseases is funded Penrith, Blacktown, Bankstown see the tiny particles inside a living as an important component of and Campbelltown areas. cell, but also to ‘slice’ it very finely so Overview grant income from the NHMRC, Symposia and lectures improving Australia’s health care all the components of the cells can be Australian Research Council and other Since its establishment in 1994, The VCCRI believes in creating and hospital system into the future. visualised individually. funding bodies - an increase of almost The VCCRI continues to hold the Victor Chang Cardiac Research an environment that encourages weekly tours of the institute for the 20% over the past two years. On a sad note, this year we My most sincere thanks also to our Institute (VCCRI) has been committed collaboration and communication public, to give them an insight into farewelled our finance manager, Board, headed so ably by Mr. Steven to unlocking the mysteries of heart among researchers, clinician scientists the research we are conducting. Awards and honours Monica O’Loughlin, who tragically Lowy, AM, our Appeals Committee, disease. Despite the disruption of and students. In addition to our The tours have proved to be very Further evidence of the Institute’s died suddenly of heart disease while chaired by Mr. John McGuigan, moving into the new Lowy Packer regular seminars, we host a yearly popular with Probus, Rotary, Lions scholarship is the many awards and visiting her mother. She is much our Finance Committee, headed building at the end of 2008, we have international Princesses’ Lecture. and View Clubs. Our researchers fellowships garnered by our faculty missed by all at the institute, and by Mr. John Kean, the Sisters of been able to maintain our momentum, In 2008 and 2009, two world were also invited to speak about the and trainees. Some of the highlights sadly her death at such a young age Charity, and all of our scientific and with continued strong progress and renowned researchers, Professor institute’s work and heart disease to from the past two years include again highlights the fact that heart administrative staff. many discoveries in 2009. Of course Richard Henderson from the MRC various community groups. We again of course the prestigious Australia disease claims four times more this new facility is much needed Fellowship awarded to Professor Laboratory of Molecular Biology in participated in the Science in the City women’s lives than breast cancer and gives us the opportunity to now Richard Harvey. In addition, Monique Cambridge and Professor Andreas Expo, and Science Exposed, which or indeed any other cause. move ahead at an increased and by Ohanian who, whilst at high school, Zeiher from the University of Frankfurt are aimed at school students. expanding our research team. won the VCCRI Science Award and were our Princesses’ lecturers and Education then went on to win the University spoke at two further international In this our 15th year of operations, of Western Sydney Dean’s medal for symposia that the Institute organised In 2009, PhD degrees for work I am pleased to report that an her honours project conducted jointly – these symposia also featuring many carried out at the institute, in independent survey by the Australia with the VCCRI. Monique has now other nationally and internationally conjunction with the University of National University ranked the VCCRI commenced her PhD with us. James acclaimed scientists and clinicians. NSW Faculty of Medicine, were 6th out of Australia’s top 37 medical Chong was awarded the inaugural In 2009, the Honourable Jodi McKay, awarded to Alfred Hing and research institutes. The report also NSW Fulbright Australia-America NSW Minister for Science and Jacque-Lynne Johnson. Carol Mark showed that we have established a Commission Fellowship, which Medical Research, who has been a was awarded First Class Honours strong international reputation with supports students to complete their strong supporter of our sector, kindly in bioinformatics. our research having almost double PhD in Australia or the United States. opened the last of these symposia. the impact of that of biomedical Alasdair Watson has been awarded research carried out worldwide and a research fellowship from the Royal by Australian universities and other Australasian College of Surgeons. Robert M. Graham, AO, FAA, MD Executive Director research organisations. Professor Peter MacDonald Since our last annual report, our was nominated as an Australian of the Year and has also been researchers have published 128 appointed the president-elect of the research papers in highly regarded Transplantation Society of Australia journals as well as eight book and New Zealand. A full list of our chapters, and in 2009 our researchers awards and honours recipients can attracted a record $10.6 million in be found later in this report.
6_The VCCRI Annual Report 08/09 7_The VCCRI Annual Report 08/09 Victor Chang (1936-1991) VALE
• • • A pioneer of the modern era of heart • • • transplantation, Victor Chang established the National Heart Transplant Unit at St. Vincent’s Hospital in 1984.
Healer of Hearts — Victor Chang (Yam Him) was born in Shanghai of Australian born Chinese parents. He came to Australia in 1953 to complete his schooling at Christian Brothers College, Lewisham, and then moved to medical training at Sydney University. Graduating in A pioneer of the modern era of 1962, he became an intern and later Monica Frances O’Loughlin John Patrick Joseph Baker heart transplantation, Victor Chang a registrar in cardiothoracic surgery at February 2, 1958 – 5 May, 2009 February 23, 1929 –August 15th, 2009 established the National Heart St. Vincent’s Hospital. — — Transplant Unit at St. Vincent’s After completing additional training in Hospital in 1984. The Victor Chang Cardiac Research Institute When John Baker entered a room he certainly England, and then at the prestigious (VCCRI) lost one of its most treasured made his presence felt. If it wasn’t his colourful During the 1980’s he became Mayo Clinic in the US, he returned to employees on May 5, 2009. Our Finance attire, matching shirts, socks and braces that got widely known as a man of vision, St. Vincent’s Hospital in 1972 to join Manager Mrs. Monica O’Loughlin, wife and everyone’s attention, it was his grand entrance. as a caring surgeon, as a researcher the elite St. Vincent’s cardiothoracic mother of 5 died suddenly from a heart attack He had the knack of turning a stressful meeting and as an ambassador for Australia team that already included Harry whilst visiting her mother in Taree. into a fun event making everyone laugh with and the people of South East Asia. his witty comments and, at times, risqué jokes. Windsor and Mark Shanahan. Monica joined the VCCRI over eight years ago, During this time he nurtured a He was an integral part of the Victor Chang Ball initially on a part-time basis, but then soon became vision to establish an internationally committee and even at the tender age of 80 still a full-time employee looking after the Institute’s recognised cardiac research centre at did his bit to ensure the event was a great success. St. Vincent’s and to this end, in 1990 finances which was a massive task especially he and others launched the “Heart of during the construction period of our new building. The perfect guest, John was a gentleman through and through. He garnered friends from around St. Vincent’s Appeal”. Coping with full-time work and the demands the world and kept in touch with each and every of a large family weren’t enough for Monica, in one of them. He never forgot birthdays or special her spare time she managed to get a diploma in occasions and sent the most fitting cards. He sent psychology and had started an honours degree at postcards from wherever he was visiting. The only the time of her death. problem being his writing – it was appalling – he’d Monica was always quick to volunteer to help be home before you could decipher the few words at any fundraising events and embraced all the he had written on the card! ‘special’ holidays with great enthusiasm. John Patrick Joseph Baker died on August 15 at Monica was much loved by the Institute and her St. Vincent’s Hospital. We loved him and we miss death has had a great impact on us all. him. But he has left us with a legacy of many happy memories. Her family remain in our thoughts and prayers.
8_The VCCRI Annual Report 08/09 9_The VCCRI Annual Report 08/09 THE INSTITUTE
• • • With funds donated, St. Vincent’s Hospital established the Victor Chang Cardiac Research Institute, which was launched on February 14, 1994. History Royal Opening — — With his tragic and untimely death in Sydney on Her Royal Highness Crown Princess Mary of Denmark July 4th, 1991, efforts to realise Victor Chang’s dream officially opened the Lowy Packer Building on Wednesday accelerated, resulting in generous donations from the September 3, 2008 in front of 250 guests. That night both Federal Government, the late Mr. Kerry Packer, AC, and their Royal Highnesses Crown Prince Frederik and Crown the Australian public. Prince Mary attended a celebratory dinner in the building. With these funds St. Vincent’s Hospital established the The $80 million purpose-built facility, together with Victor Chang Cardiac Research Institute, which was the existing Garvan Building, houses the St. Vincent's launched on February 14, 1994 by the then Prime Minister Research Precinct, the largest biomedical hub in NSW of Australia, the Hon. Paul Keating, with the late Mr. Kerry comprising the Victor Chang Cardiac Research Institute Packer, AC as its Patron and Professor Robert Graham as (VCCRI), the St. Vincent's Centre for Applied Medical its Executive Director. Research and the Garvan Institute of Medical Research. On February 27th 1995, the Institute was incorporated as The Lowy Packer Building was built with funds kindly an independent research facility with the Hon. Neville Wran, provided by the NSW State Government and Australian AC,QC as its Chairman, and on November 1, 1996 the late Federal Government, as well as generous donations from Diana, Princess of Wales opened the Institute in its then The Atlantic Philanthropies, the Lowy and Packer families, new premises in the Garvan Building. In 2004, Mrs. Ann the National Australia Bank, ANZ Bank and Citigroup, along Chang became a Patron of the Institute, in 2005 Her Royal with many other generous donors. Highness Crown Princess Mary of Denmark, an Honorary Her Royal Highness unveiled a plaque and a bronze Life Governor and in 2008 the Hon. Neville Wran, AC, QC, life-sized sculpture of the late esteemed cardiac surgeon our inaugural Chairman retired and became a Patron. Dr. Victor Chang, which sits in front of the building. The opening was also attended by the then Premier of New developmental Biology 07 South Wales, the Hon. Morris Iemma, MP and the building 01 Lowy Packer Buidling was blessed by His Eminence, George Cardinal Pell. 02 03 Mrs Ann Chang and The new building will allow the VCCRI to expand its 06 Her Royal Highness Crown research and develop vital ancillary core facilities, such Developmental Biology Princess Mary of Denmark as X-Ray crystallography and will provide increased opportunities for research training of students undertaking BSc (Hons), MSc, MD or PhD degrees as well as training Molecular Cardiology postdoctoral students. & Biophysics 05 Molecular genetics Structural & Computational Biology
02 Administration & FInance 04
reception 03
01 03 Biocore Facility & Aquarium 02
10_The VCCRI Annual Report 08/09 11_The VCCRI Annual Report 08/09 15 Years of Discovery
• • • 2004 1996 2000 2006 2009
1998 2007 1994 2001 1995 2005
1997 2003 1999 2002 2008
2009 marked the 15th Birthday of The Victor Chang Cardiac Research Institute. Our researchers are passionate, dedicated and committed to finding a cure for heart disease.
1994 1996 1999 2001 2003 2004 2006 2008
The VCCRI officially launched Molecular structure, An entirely unexplained but Since the human gene has Muscle is composed of Major advance in the Groundbreaking evidence 2. Interactions between Researchers find that the 2. Circumstantial evidence by the Prime Minister the Hon function, and signaling. important phenomenon – in been sequenced we now know two types of fibre – fast understanding of adult showing how dietary choices inherited gene changes and embryonic mouse heart has shows that placental Paul Keating, MP with Mr. Major review of the family of identical twins disease severity the order of millions of DNA twitch provides strength stem cell biology and in the in pregnancy affect children stretch or dilation of the low an astounding capacity to insufficiency may also affect Kerry Packer, AC as Patron proteins on the surface of cells can vary markedly. ie one twin bases. What cannot fully be and slow twitch is required application of adult stem cells for at least two generations. pressure upper chambers regenerate, a phenomenon renal medullary growth that allow adrenaline, released may have very severe disease, predicted from this sequence for endurance. Previously to treat cardiac disease. In an international first, of the heart, the atria, may previously observed only in which could account for Reported for the first time that at times of stress, to regulate the other is only mildly affected is where all the genes lie unidentified signals have our researchers reported be important in the onset non-mammalian species. cases of unexplained renal an enzyme involved in forming heart function. or normal. Given that such compared to all the extra DNA been discovered that control Although it has been long that the diet of pregnant of atrial fibrillation, which medullary dysplasia and protein polymers is also able to twins have identical genes, the material. For the first time the the development of slow known that structural gene – mothers can affect, not only is the most common heart 2009 for abnormalities in renal function as a critical molecule 1997 difference is not in the genes precise location of thousands twitch muscles in zebrafish. defects (or mutations) can be in the children, but in their rhythm abnormality in our function among infants linking the activation of cells, inherited and cause disease, themselves but differences in of genes that are active in the The findings should be grandchildren as well. community and is a major 1. A world-first technique which had experienced such as those in the heart, with it was a surprise to find that Clumping of red blood cells how their genes function. developing embryo which is directly applicable to our risk factor for heart failure has been developed that intrauterine growth enhanced functioning of these so too can defects in gene results in changes that can be critical for reading our genome understanding of human and stroke. will almost double the retardation. cells in response to stress. activity (epimutations). 2007 observed non-invasively with 2000 map has now been discovered. muscle development life of donor hearts being anechocardiogram and used and physiology, and 1. Breakthrough discovery 3. Abnormalities in a cardiac transported to transplant 1995 to diagnose patients with an When both copies of the gene 2002 muscle diseases. 2005 in understanding heart gene TBX20 (a member of surgery. increased risk for blood clots the T-box family of genes Major finding demonstrates Nkx2.5 are not functioning, problems in babies by and strokes. the heart fails to develop, A detailed review of inherited A breakthrough discovery addressing origin of heart that regulate how other Medical scientists have how the metabolism of an causes of heart muscle in how a newly uncovered sets of genes are turned expensive immunosuppressant but if only one of the genes defects and discovering that successfully trialed a new 1998 is defective, this results in a disease that result in excessive natural mechanism works to certain types of congenital on and off in the embryo) combination of drugs that drug used in transplant patients thickening or dilation of the control how much protein is which are responsible for can be slowed by the use higher rate of hole in the heart, heart problems occur at a will extend the time a donor Landmark study heart disorders that often produced from a gene. heart malformations in of another cheaper drug the commonest form of heart much earlier stage in the heart can spend in transit, demonstrating the far lead to severe heart failure children identified. used to prevent infections disease present at birth. development of a baby than from the current four to five reaching benefits of lowering requiring a heart transplant in these patients. ever expected. hour limit, up to 14 hours. cholesterol regardless of how was undertaken. 4. Patients with severe heart high it is before treatment. disease may soon have Researchers say the access to a simple injection technique will give greater to help manage their scope to accept a variety of symptoms and reduce donors, including those from their need for large interstate and overseas. amount of pain relief.
12_The VCCRI Annual Report 08/09 13_The VCCRI Annual Report 08/09 Board of Directors
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The successful operations of The Victor Chang Cardiac Research Institute are heavily reliant upon the dedication, commitment and vision provided by the Mr. John McGuigan Professor. Leslie D Field Board of Directors and subsidiary committees. LLB BSc, PhD — — John McGuigan is a co-founder Professor Field was appointed to of Hunter Bay Partners, a private his current position as Deputy investment company with Vice-Chancellor (Research) at investments in the Energy and Food the University of NSW on sectors. He has both an accounting Mr. Angelos Frangopoulos 29 March 2005. Mr. Chum Darvall and legal background, leading to BA(Comm), MAICD, JP BA, FFin, FAICD His main areas of research are senior positions at Price Waterhouse — — organometallic chemistry, catalysis and then Baker & McKenzie. Angelos Frangopoulos is the CEO of and NMR spectroscopy. He is the Chum Darvall was appointed Mr. Steven Lowy Jill Margo He has served on the boards of Australian News Channel Pty Ltd. author of more than 170 scientific Chief Executive Officer Deutsche AM (Chairman) AM, BA (Hons) a number of public and private papers and 4 text books. He was Bank Australia and New Zealand He joined the company in companies, and maintains an active recipient of the Organic Chemistry in July 2002. He joined the bank — — July 1996, 5 months after the involvement in charitable and civic Medical of the Royal Australian in September 1994 as Director channel’s inception. Steven Lowy was appointed Jill Margo is a medical journalist organisations. In addition to serving Chemical Institute in 1994 and was Treasury managing the money managing director of Westfield on The Australian Financial Review. as a Director of the VCCRI, he is Before joining Australian News elected as a Fellow of the Australia market, swaps and foreign exchange Holdings in 1997 and currently She has won 17 international and Chairman of its Appeals Committee. Channel, he held positions at British Academy of Science in 1996. units and group funding. In early serves as group managing director of Professor Ian Dawes national media awards, including Professor. Robert M. Graham Sky Broadcasting, the Nine Network 1998, he became Head of Global the Westfield Group. Mr. Lowy holds BSc, DPhil (Oxon) two Walkleys. Since 2000, she AO, FAA, MBBS (Hons), MD, and Prime Television Canberra. Markets responsible for all financial a Bachelor of Commerce (Honors) — has been a member of working FRACP, FACP, FAHA market-related activities. Chum was degree from University of NSW. parties charged with developing — also part of the management group Prior to joining Westfield in 1987, Professor Dawes is Scientia clinical and consumer guidelines responsible for the integration of the he worked in investment banking in Professor of Genetics in the School for the management of prostate Professor Graham is Executive New Zealand operation of Bankers the US. Mr. Lowy is President of the of Biotechnology and Biomolecular cancer. In 2006 Jill was awarded Director of the Victor Chang Cardiac Trust with Deutsche Bank in 1999 Board of Trustees of the Art Gallery Sciences. He is also Director of the an Order of Australia for services to Research Institute and a member of New South Wales; a director of Ramaciotti Centre for Gene Function journalism and cancer. She holds a of its Executive Management, Chum is a council member for the the Lowy Institute for International analysis and an ARC Professorial BA (Honours) in English literature, is Appeals and Finance Committees. Business Council of Australia and Policy; a member of the Prime Fellow as well as a university a best selling author and biographer. He is the Des Renford Professor sits on a number of Boards. Minister’s Business-Government medallist and Rhodes Scholar. of Medicine, and Professor of Mr. David Craig Mrs. Barbara Matthews Advisory Group on National Security; Biotechnology and Biomolecular BEC, FCA, CTFP — — and Chairman of the Board of Science, University of NSW, and Born in Auckland, New Zealand and Management for the Associate Professor (adjunct) of Physiology David Craig commenced as educated at St. Mary’s College prior Degree of Policing Practice (ADPP). and Biophysics, Case Western Chief Financial Officer of the Mr. John Kean to her nursing training at Auckland Past Board Members Reserve University School of FCA, FAICD Hospital, Barbara then continued — Medicine, Cleveland, Ohio. He Commonwealth Bank in September 2006. — her nursing career at Merriwa Mr. Kerry James, AM is Fellow, Australian Academy of District Hospital. After marrying, Mrs. Ann Chang Science, and a member of the David has over 30 years of John Kean is Executive Chairman Barbara moved to Sydney, where American Association for Clinical experience in financial management, of Pinpoint Pty Limited. He she raised her three children, Dr. Tina Clifton Research, the American Society of strategy, mergers and acquisitions. was a founding Partner of Justine, Sara and Robert. In addition Mr. Paul Kelly Mrs. Ros Packer Clinical Investigation, the American Prior to joining the Bank, David was WHK Greenwoods, Chartered to serving on the VCCRI Appeals Mr. John Laws, CBE AO Heart Association, and the National Chief Financial Officer for Australand Accountants. Committee, Barbara is widely — Heart Foundation of Australia where he was responsible for Mr. Malcolm Irving, AM He also acts as an Independent recognised for her leadership in (NSW Division). leading the finance, treasury, IT Dr. Gary H. Weiss Sr. Anthea Groves Business Advisor and holds philanthropy and charity work. Sr. Paulina Pilkington, AM, RSC Mrs. Packer is a member of the and investor relations functions. LLB (Hons), LLM OAM, RSC, RN LHA Dip. Board of Trustees of St. Vincent’s Directorships in various businesses Mr. Cameron O’Reilly of Nursing Administration — Clinic Foundation. She is also a involved in marketing, finance, The Late Sr. Claire Nolan, RSC — member of the Board of Directors retail, primary production, Gary Weiss is chairman of Coats Ms. Anne Keating of the Sydney Festival, member of technology and international plc and an Executive Director of Sr. Anthea is a member of the the Council of the National Gallery trade. In addition to serving as a Mr. Mark Johnson, AO Guinness Peat Group plc, Ariadne congregation of the Sisters of of Australia, and Patron of the Director of the VCCRI, he chairs the Mr. Sam Chisholm Australia Limited, Tag Pacific Charity and is Patient Liaison Officer ladies Committee, St. Vincent’s Finance Committee and has been a Limited, the Westfield Group and at St. Vincent’s Hospital Sydney. Private Hospital. member of the Appeals Committee Premier Investments Limited. Sr. Anthea is a Director of the Sisters since its inception. of Charity Foundation.
14_The VCCRI Annual Report 08/09 15_The VCCRI Annual Report 08/09 COMMITTEES Research Programs
• • • • • • B iology
Finance Committee
—
The Finance Committee is responsible for the oversight of finances enetics omputational for the Board of Directors. The Committee oversees the audit of the G VCCRI’s accounts, investment management, management remuneration, structural & C DanielaDr. Stock Acting Division Head MerrideeDr. Wouters Group Leader and also sets finance policy for management to follow. hysiology
Members include P
– Mr. John Kean M olecular A/Professor Thomas Preiss Acting Division Head Dr Catherine Suter Lab Head – Mr. David Craig ransplantation ardiac & T C Professor Michael Feneley Division Head Professor Anne Keogh – Mr. Chum Darvall Lab Head Professor Peter Macdonald Lab Head A/Professor David Muller Lab Head O’Rourke Michael Professor Lab Head – Professor Bob Graham, AO – Ms. Jan Savage – Ms. Carla Northam – Mr. Bhavin Raval – Ms. Beverley Hillsdon Appeals Committee Mrs. Monica O’Loughlin was a member of the Finance Committee until her death in May, 2009. — The Appeals Committee consists of a group of Intellectual Property and volunteers & institute staff who are responsible for the Institute’s fundraising events to raise the Commercialisation Committee vital funds needed by the Institute to conduct its — groundbreaking research. The Intellectual Property & Commercialisation Committee (IP&CC) Members include is responsible for the oversight and management of the intellectual – Mrs. Ann Chang property and commercialisation activities of the Institute. The Committee – Mrs. Barbara Matthews meets formally twice a year, and on a “needs to” basis at other times. – Professor Robert Graham, AO Members include – Mr. John McGuigan (Chairman) – Mrs. Linda Duncombe – Professor Robert M. Graham, AO – Mr. John Kean – Ms. Mhairi Donohoe – Sr. Paulina Pilkington, AM – Ms. Anne-Marie Allgrove – Mr. Michael Renford – Dr. Trevor Davies – Mr. John Shim – Professor Joan Dawes – Mrs. Antoinette Ogilvie – Ms. Britt Granath – Mr. Russell Feilen – Dr. Melissa McBurnie – Ms. Bernie Connolly – Mrs. Carla Northam – Mr. Peter Homan – Ms. Jan Savage
– Mrs. Stephanie Hughes
– Mr. Rob Tunchon
– Mr. Alan Crouch – Ms. Anne-Marie Allgrove
– Mr. Robert Ryan
– Mrs. Louise Di Francesco ardiology
– Mr. Ross Kosarchsky C – Mr. Das Menon – Mr. Kerry James, AM evelopmental Division Head A/Professor Sally Dunwoodie Lab Head D Professor Richard Harvey B iology Lab Head & B iophysics Division Head Professor Terry Campbell Lab Head Professor Boris Martinac Lab Head A/Professor Diane Fatkin Lab Head A/Professor Jamie Vandenberg M olecular Professor Bob Graham, AO
16_The VCCRI Annual Report 08/09 17_The VCCRI Annual Report 08/09 VCCRI AWARDEES
• • •
The Heart and Soul of the VCCRI
— 03 Our voluntary Committee Members, Patrons, Life Governors, Ambassadors, Life Members, Donors and Supporters are the heart and soul of the VCCRI. Their dedication, commitment and encouragement of our research is unconditional. We thank them for their generosity, enormous time and the expertise they provide so willingly and freely.
04
Patrons Life Governors Ambassadors NOW
14HRS — — — – Mrs. Ann Chang – Abigroup – Baker & McKenzie – The Hon Neville Wran, AC, QC – ANZ Bank – The Crane Group Past Patron – Mr. Sam Chisholm – Crestbrook Mountain Springs – Citigroup – The late Mr. Alan David 4HRS B efore — – Mr. John David – The late Amana Finley – The Late Mr. Kerry Packer, AC – Mrs. Barbara Ell – Mr. John Laws, CBE – Lady Mary Fairfax, AC,OBE – Mr. Ken Laing, AM Honorary Life Governor – The late Lady Finley – Schute Bell Badgery Lumby — – The Freedman Foundation – Steve Costi Seafoods – Her Royal Highness – The Freshest Group – Mr. & Mrs. Scott & Rhonda Gibbons Crown Princess Mary of Denmark – Mr. Frank Lowy, AC – Mr. & Mrs. Russell & – Mr. Steven Lowy, AM Julieanne Cooper – Mr. James Packer – Mr. & Mrs. John & Margaret Ingram – National Australia Bank – Mr. & Mrs. Ralph & Lorraine Keyes – Mr. Robert Oatley – Guinness Peat Group – Strathfield Group Limited – Club Marconi – Mr. Ziggy Switkowski – LK Jewellery – Telstra Corporation – Mr. Cameron Irving – Mrs. Jennie Thomas, AM – Deutsche Bank – Mr. Lance Rosenberg – Mr. Mark Johnson, AO Honorary Life Members – The late Mr. Ken Lee —
01 – Mr. & Mrs. David & Diana Ritchie – Ms Fiona Coote, AM
– The Atlantic Philanthropies – Mr. Kerry James, AM – Ingham Enterprises – Mrs. Roslyn Packer, AO Young Ambassador Award — – Mr Mark Vincent physiology
02
01 Ralph & Lorraine Keyes with Bob Graham and Steven Lowy
transplantation 02 Ingham Enterprises, John Ingham with Bob Graham & Steven Lowy 03 LK Jewellery's Martha Kennedy with Bob Graham & Steven Lowy 04 Mark Vincent receiving his Young Ambassador Award blood flow,” said Professor Bob Graham, Executive Executive Graham, Bob Professor said flow,” blood being transported transplant for surgery. like Australia and the time it can take to transport a transport to take can it time the and Australia like heart from a donor a recipient.” to Director of the Victor Chang Cardiac Research Research Cardiac Chang Victor the of Director a longer period, we will reduce deterioration and and deterioration reduce will we period, longer a Research Institute (VCCRI) and St. Vincent’s Hospital Hospital Vincent’s St. (VCCRI)and Institute Research therefore allow the heart to function more quickly and and quickly more function to heart the allow therefore the more it will deteriorate, increasing the risk of injury injury of risk the increasing deteriorate, will it more the
Institute. 41_The VCCRI Annual Report 08/09 (SVH) that will almost double the life of donor hearts hearts donor of life the double almost will (SVH)that or death even during transplantation, due restricted to effectively after surgery,--- added Professor Graham. and cardiac • A world-first technique has been developed by developed been has technique world-first A Cardiac Chang Victor the at scientists Australian Medical scientists have successfully successfully have scientists Medical can drugs of heart combination a new trialed donor a time the four current extending the from transit, in spend hours. 14 to up limit, hour five to “If we can we “If successfully preserve the donor heart for “This is a major issue given the vast countries of size “The longer a donor heart lives outside the recipient, AWARDS AND AWARDS AND ACHIEVEMENTS 2008 ACHIEVEMENTS 2009
• • • • • • Achievements Achievements — — Dr Catherine Suter Wendy Saad Professor Robert Graham Adam Hill Degrees Awarded — Received funding from the Cure Cancer Awarded the John Yu Scholarship by Awarded an AO in the Queen’s Birthday Elected NSW State Representative for Alfred Hing Australia Foundation as well as being the Royal Alexandria Hospital (Children’s Honours for service to medicine, the Australian Society for Biophysics. selected as the 2008 Macquarie Group Hospital at Westmead) to complete her particularly through stewardship of the Awarded his PhD at the University of Professor Richard Harvey Foundation Fellowship. Honours degree in B.Medical Science Victor Chang Cardiac Research Institute New South Wales (Faculty of Medicine, through Sydney University. and research in the field of molecular Won the Australian and New Zealand St. Vincent’s Clinical School). Alfred’s Dr Merridee Wouters cardiology. Society of Cell and Developmental project “Optimising the quality of donor Jacque-Lynne Johnson Awarded International Travel Grant Biology President’s Medal and Oration organs for transplantation: Studies of Lawrence Lee at the Joint 52nd Annual Meeting of Received an NGED conference (presented at Combio 2009). hormone resuscitation of the brain-dead Biophysical Society and 16th IUPAB participation award to attend the 2008 Awarded the “Best Postdoc Talk” multi-organ donor and the development Degrees Awarded James Chong International Biophysics Congress Santa Cruz Developmental Biology for his presentation “The structure of a long-term preservation strategy to — at Long Beach California, February Meeting June 26-29 at UC Santa Cruz. of the torque-generating ring of the Won the inaugural NSW Fulbright optimise function of the transplanted 2-6 2008. Marco Nousch bacterial flagellar motor and the Australia-America Commission heart in a porcine model” demonstrated Monique Ohanian molecular basis for the rotational Fellowship for 2010. that the use of hormone resuscitation Professor R M Graham, AO Awarded his PhD at the University Received the Lorna Byrne Public switching at the 2009 East Coast of the organ donor improved the quality of New South Wales, School of Paul Korner Seminar Series 2009 Will commence a 2-year term as Protein Meeting”. and function of the donor heart. Speaking Trophy for Best Honours Biotechnology and Biomolecular President, Australian Association thesis presentation, School of Natural Sciences. Alastair Stewart Lawrence Lee was the winner of the Jacque-Lynne Johnson of Medical Research Institutes in Sciences, University of Western 2009 Paul Korner Seminar Series with November 2008. Sydney. Milena Furtado Awarded the “Best PhD Student Sharon Chih and James Chong the Awarded her PhD at the University Talk” for his presentation “Molecular runners up. The Staff Choice Awards of NSW (Faculty of Medicine). A/Professor Sally Dunwoodie Leah Cannon Awarded PhD, University of New South Architecture of the T.thermophilus were presented to both Chris Blair and Jacque-Lynne’s project: “The role of Wales (Faculty of Medicine). Won the inaugural Australian & Awarded the Cardiac Society Australia A-ATPase Stator Complex”. Liz Yeo. the zebrafish scube gene family in New Zealand Society for Cell & & New Zealand (CSANZ) Travelling Edwin Kirk Hedgehog signaling and slow muscle Christiana Leimena Cheryl Li Developmental Biology (ANZSCDB) Fellowship to attend the American development” investigated how this Awarded PhD, University of New family of three genes interacted with Young Investigator Award. Heart Association Scientific Sessions in Received The Miltenyi Biotech Awarded best oral presentation from South Wales (School of Women’s and the Hedgehog pathway to specify New Orleans in November 2008. Student Poster Prize at the 19th St. a student at the Annual Epigenetics Laura Ng Children’s Health, Faculty of Medicine). slow muscle cell fate in the developing Vincent’s & Mater Health Sydney Conference in Melbourne. Professor Richard Harvey zebrafish embryo. Jacque-Lynne Has received the D.I. McCloskey Prize Ishtiaq Ahmed Research Symposium. showed that all three scube genes were for Physiology/Pharmacology Honours. Elected as an Associate Member Awarded his PhD at the University Cheryl Li required for slow muscle development of the European Molecular Biology of Durham (Faculty of Biological and and functioned redundantly in slow Dr Arie Jacoby Organisation (EMBO). Received the Genesearch Award for Biomedical Sciences). muscle specification acting upstream of Excellence in Oral Presentation at the Received a Network in Genes and Dr Rob Bryson-Richardson the obligate receptor patched. Jacque- 19th St. Vincent’s & Mater Health Environment in Development (NGED) Lynne was awarded an International Received a travel award from the Sydney Research Symposium. Conference Participation Award to Postgraduate Award from the University NGED, which allowed him to be an attend the 8th International Meeting on of New South Wales to undertake invited instructor at the European Zebrafish Development and Genetics in her PhD at the Victor Chang Cardiac Molecular Biology Organisation (EMBO) the USA in June 2008 and was selected Research Institute. to speak in a “plenary session”. practical course on 3D Developmental Imaging in Lisbon, Portugal. Carol Mak Paul Korner Seminar Series 2008 BE Bioinformatics Honours Class.
Adam Hill was the winner of the 2008 Paul Korner Seminar Series with Traude Beilharz runner up and the Staff Choice Award being presented to both Leah Cannon and Lawrence Lee.
42_The VCCRI Annual Report 08/09 43_The VCCRI Annual Report 08/09 Paul Korner Paul Korner Seminar Series 2008 Seminar Series 2009
• • • • • •
Lawrence Lee Vashe Chandrakathan Duncan Sparrow Stanley Artap
Unsolved Mysteries of the Rotary “Characterization of A Novel “Placental insufficiency and “Cited2 is necessary for ATPase Enzymes “Marvelous Cardiac Cell-Type With Stem and embryonic kidney formation” determining the left-right body Claus Hallwirth Rotary Engine(s) of the Cell” Sam Fan Progenitor Cell Properties” Jason Liu Alasdair Watson axis and to the development of Marion Mohl the placenta in the mouse” “Investigating the closed-loop Nick Cole “A structure based method Adam Hill “Gentrepid: A candidate gene “Exploring the non- “Involvement of a novel alpha1A- model of mRNA translation in for identifying redox-regulated prediction system and webserver” haematopoietic effects of Vesna Nikolova “Morphogenesis and evolution of “Risk stratification in LQTS2: adrenergic receptor signaling eukaryotes” cysteine residues in yeast” erythropoietin in cardiac vertebrate appendicular muscle Laboratory insights into a clinical Orit Wolstein pathway in cardiac contractility” “When Nesprins Snap - Getting to transplantation” Arie Jacoby formation” Chris Blair problem.” the Core of Heart Disease” “Tbx20 Is Essential For Cardiac Jeff Squires Liz Yeo “Damage and recovery of skeletal Cheryl Li “Assessment of a multipotent Jennifer Cropley Proliferation And Differentiation Munira Xaymardan “Investigating RNA methylation muscle: why softy is hardy” marrow stormal cell therapy for Independently of Tbx2” “Evaluation of mechanisms of “Epigenetic programming “Epimutation in health and with bisulfite sequencing” “Characterization of Sca-1+/ cardiac repair in a murine model of contractile dysfunction in mouse Traude Beilharz in a perturbed intrauterine disease” Kylie Lopes-Floro PECAM-1-/PDGFRa+ Cardiac acute myocardial infarction” Michelle Holland model of dilated cardiomyopathy, environment.” Stem Cells” “Finding the targets of miRNA Christiana Leimena “Branching out into hypoxia: The Lamin A/C-deficient mice” Ting Wai Yiu “Profiling the transcriptome during mediated repression” James Chong role of Hif1a during placental Chris Blair “Familial Atrial Fibrillation and cardiac differentiation and other Mark Perrin “Transglutaminase 2: a dynamic development” Ling Gao “Where did I come from? Role of BKCa Channel in normal projects” “Mesenchymal stem cell modulator of fibroblast adhesion “The kinetics of hERG drug – A Cardiac Stem/Progenitor Cardiomyocyte Function and Traude Beilharaz transplantation for functional pathways and skin wound healing Gavin Chapman binding and their effect on high “Polypharmaceutical Strategies Cell Perspective” Heart Disease.” recovery following acute against Ischemia-Reperfusion in mice” “Working in Circles: The throughput screening assays” “Expression and localisation of myocardial infarction” Injury in Donor Heart Preservation” Joachim Berger David Wang determination of mRNA Alex Shaw Notch pathway proteins during Simon Keam configuration in active translation” Merridee Wouters Duncan Sparrow “sapje, a model for Duchenne “The use of phi value analysis somitogenesis” “MicroRNA repression of “piRNAs and the aberrant Muscular Dystrophy” to investigate the inactivation Romaric Bouveret “Data Mining: a tool for p53 contributes to survival Scott Kesteven silencing of genes” “SNP, SNP, Array for Affymetrix! mechanism of the human ether- knowledge discovery” Getting HESterical about SCD” Stefan Mann of embryonic stem cells and “Heart development in plants” a-go-go-related gene (HERG) “Developmental Changes in Sam Fan neuroblastomas” Andy Mg Kylie Lopes-Floro “Electrical transgenesis: potassium channel” Ling Gao Ventricular Diastolic Function” “Structure-based identification of a dynamic approach” David Humphreys “Getting to the heart of hERG K+ Andrew Jabbour redox-regulated thiols” “Cited2 is required for left-right “Cardioprotective effects of channel gating” asymmetry, but where on earth Liz Yeo “Contribution of poly(A) tail sodium hydrogen exchange “Targeting Myocardial Apoptosis Ting Wai Yiu does it act? Weighing up the deadenylation in miRNA inhibition by Zoniporide: Adam Hill “Evaluation of mechanisms and Ischaemia Reperfusion evidence” mediated repression”. association with pro-survival “Transglutaminase 2: a role in skin of contractile dysfunction and Injury. Recombinant Human “Unlocking the gate to potassium signaling pathway activation” wound healing” Tom Hall hypertrophy development in Mark Perrin Neuregulin-1 in Heart Failure and channel inactivation” Lamin A/C-deficient mice” Lawrence Lee Transplantation” James Chong “Dystrophic models and “State Dependent Drug Binding David Szekely post-embryonic muscle growth Leah Cannon to hERG” “The Victor Chang’s first protein Alex Shaw “An Epicardial Origin for Sca1+/ “An improved curvilinear in zebrafish” crystal structure - The molecular CD31-/PDGFRa+ Cardiac Stem “Characterisation of a Regulatable Robert Bryson-Richardson “miR-380-5p represses p53 to gradient method for model basis for rotation and switching of Cells” Michelle Woolford Mouse Model of Left Ventricular control cellular survival and is parameterisation: application to a “Muscle Specification and Early the bacterial flagellar rotary motor” Hypertrophy” 01 associated with poor outcome in Sharon Chih novel hERG model” “Investigating the function of Onset Myopathies in the David Humphreys neuroblastoma” Gfpt2 in heart development” Jair Kwan Zebrafish” “Granulocyte-colony Vashe Chandrakathan “Two small RNA stories: Leah Cannon stimulating factor to stimulate Romaric Bouveret “Strategies to improve donor Merridee Wouters “A cardiac cell-type with stem and (i) Contribution of poly(A) neovascularisation in chronic heart preservation during cardiac “Investigation of the pathogenesis progenitor cell properties in the “Disulfides as Redox Switches in tail in miRNA function and angina” “Genome-wide identification transplantation” of LVH due to the R403Q MHC developing and adult murine heart” of target genes of key cardiac protein Structures” (ii) Early experiences in mutation” Christiana Leimena transcription factors” preparing small RNA libraries for Solid deep sequencing.” Cheryl Li “Role of BKCa Channel - in the 02 normal cardiomyocyte and in heart Peter Riek “Epigenetic programming 01 Adam Hill,Bob Graham,Paul Korner disease” in a perturbed intrauterine 02 Lawrence Lee, Leah Cannon, “Do canonical p-helical structures environment” Bob Graham, Paul Korner exist in proteins?”
44_The VCCRI Annual Report 08/09 45_The VCCRI Annual Report 08/09 Barbara Ell Barbara Ell Seminar Series 2008 Seminar Series 2009
• • • • • • Dissecting the cellular and molecular layers that control Professor Bryan Williams antibody quality and prevent Director, Monash Institute of Medical Research, Victoria, autoimmunity. Dr Carola Vinuesa “RNAi and Innate Immunity”
Dr. Julie McMullen Dr. Himanshu Brahmbhatt Cardiac Hypertrophy Lab, & Dr. Jennifer MacDiarmid Baker IDI, Victoria Co-founders and Managing Directors Professor David Tremethick Professor Michael Good “Protective role of the IGF1- EnGeneIC Pty Ltd Group & Genome Biology, The John Director, The Queensland Institute PI3K(p110alpha) pathway in the heart” "Bacterially-derived nanocells for Curtin School of Medical Research, of Medical Research targeted delivery of drugs or siRNAs Australian National University, ACT Professor Charles Mackay to tumors in-vivo" "Vaccines for the developing world – “Understanding the link between Director, Immunology & status of rheumatic fever" chromatin structure and function during Inflammation Research, Dr. Marnie Blewitt early development” Garvan Institute of Medical Research WEHI , Bioinformatics Division Glenn King Group leader – IMB “Chemoattractant receptors and Dr. Rohan Teasdale "Studies on the molecular mechanisms their role in leukocyte migration, behind epigenetic control - stories about Chemical & Structural Biology Institute of Molecular Sciences, inflammation, HIV infection, and cancer” Smchd1 and polycomb group proteins" "Venomics as a drug discovery platform" University of Queensland
Professor Greg Gibson "The Dynamic Endosome: A journey Dr. Carola Vinuesa Dr. Jackie Wilce through space and time" School of Biological Sciences, Viertel Senior Medical Research Faculty of Medicine, Nursing and University of Queensland Fellow / Group Leader Health Sciences Professor Doug Hilton Division of Immunology “Genomic dissection of complex Monash University Victoria Head Molecular Medicine, and Genetics disease in flies and humans” "mRNA recognition by proteins involved Walter & Eliza Institute of Medical John Curtin School of Medical in translation regulation" Research Victoria Research Australian National University “Genetic Dissection of Blood Dr. Ryszard Maleszka Cells Formation”. "Dissecting the cellular and molecular layers that control antibody quality and Molecular Genetics and Evolution Group Dr. Eddy Kizana prevent autoimmunity" Understanding the link Research School of Biological between chromatin Faculty of Medicine, University of Dr. Melanie Bahlo Sciences Sydney & Staff Cardiologist, Dept. of structure and function "How the interplay between genes and Cardiology, Westmead Hospital WEHI, Bioinformatics Division during early development. environment generates organismal and “Transfer of Regulatory RNA "Using high throughput technologies behavioural complexity: insights from Professor David Tremethick Molecules via Gap Junctions in for disease gene identification" the honey bee epigenomics" Heart Cells”. Dr. Kevin Pfleger Professor Jennifer Gamble
Head of the Laboratory for Professor of Vascular Biology Molecular Endocrinology Medicine, Central Clinical School Western Australian Institute Centenary Institute of Cancer Medicine & Cell Biology "Monitoring G Protein-Coupled Receptor Complexes using BRET" "Regulation of Vascular Phenotypes"
46_The VCCRI Annual Report 08/09 47_The VCCRI Annual Report 08/09 Princesses’ Lecture Series Publications 2008 and International Symposiums • • •
• • •
1_ Amirahmadi F, Turnbull L, Du proper formation of the hyaloid 15_ Hashimoto J, O’Rourke 22_ Loomes KM, Stevens SA, The Princesses’ Lecture Series is an annual VCCRI XJ, Graham RM, Woodcock vasculature and for lens MF. Arterial stiffness: O’Brien ML, Gonzalez event inaugurated in 1998. The lecture series is named in EA. Heightened alpha1A- morphogenesis. Development does it predict risk over DM, Ryan MJ, Segalov M, adrenergic receptor activity 2008, 135:2939-48 blood pressure? Current Dormans NJ, Mimoto MS, honour of the late Diana, Princess of Wales and Her Royal suppresses ischaemia/ Cardiovascular Risk Reports Gibson JD, Sewell W, Schaffer reperfusion-induced Ins(1,4,5) 8_ Clarke CE, Veale EL, Wyse 2008; 2:133-140. AA, Nah HD, Rappaport K, Vandenberg JI, Mathie Highness Crown Princess Mary of Denmark, both strong P3 generation in the mouse EF, Pratt SC, Dunwoodie A. The M1P1 loop of TASK3 heart: a comparison with 16_ Hashimoto J, Nichols WW, SL, Kusumi K. Dll3 and K2P channels apposes the supporters of the Institute and its research. ischaemic preconditioning. Clin O’Rourke MF, Imai Y. Notch1 genetic interactions selectivity filter and influences Sci (Lond) 2008; 114:157-64. Association Between Wasted model axial segmental and 01 channel function. J Biol Chem. Pressure Effort and Left craniofacial malformations of 2008; 283:16985-92 2_ Bansal PS, Torres AM, Ventricular Hypertrophy in human birth defects. Dev Dyn. Hypertension: Influence of Crossett B, Wong KK, Koh 9_ Coman D, Bacic S, Boys A, 2008; 237:1754. Arterial Wave Reflection. Am J JM, Geraghty D, Vandenberg Sparrow DB, Dunwoodie Hypertens 2008;21:329-33. 23_ Martin DIK, Cropley JE, Suter JI, Kuchel PW. Substrate SL, Savarirayan R, Amor DJ. The VCCRI’s 10th International specificity of platypus venom CM. Environmental influence Spondylocostal Dysostosis in 17_ Hashimoto J, Westerhof Symposium Molecular L-to-D-peptide isomerase. J a pregnancy complicated by on epigenetic inheritance at Biol Chem 2008; 283:8969-75. BE, Westerhof N, O’Rourke the Avy allele. Nutr Rev 2008; Pharmacology of G Protein-Coupled Confined Placental Mosaicism MF. Different role of wave for Tetrasomy 9p. American 66 Suppl 1:S12-4. 3 _ Banfor PN, Preusser LC, reflection magnitude and Receptors, was held in November Journal of Medical Genetics: Campbell TJ, Marsh KC, timing on left ventricular 24_ Newton PJ, Davidson PM, 2008 and featured a number of leading Part A, 2008; 146A, 1972- Polakowski JS, Reinhart GA, mass reduction during Macdonald P, Ollerton 02 1976. international and national investigators. Cox BF, Fryer RM. Comparative antihypertensive treatment. R, Krum H. Nebulized 01 Diana, Princess of Wales effects of levosimendan, OR- 10_ Cropley JE, Martin DIK, Suter Hypertension 2008; 26:1017- Furosemide for the Speakers 1896, OR-1855, dobutamine, 1024. Management of Dyspnea: The VCCRI’s 11th International 02 Her Royal Highness Crown CM. Germline epimutation in and milrinone on vascular humans. Pharmacogenomics. Does the Evidence Support Princess Mary of Denmark 18_ Keogh A, Jabbour A, – Dr. Stephane Angers,(Canada) Symposium Cardiology at the resistance, indexes of cardiac 2008 Dec;9(12):1861-8. Its Use? J Pain Symptom Hayward C, Macdonald P. – Professor Michel Bouvier, (Canada) Frontier – Development, Stem function, and O2 consumption Manage. 2008; 36:424-41. 11_ Esteban O, Bernal RA, Clinical deterioration after Cells and Heart Failure was held in dogs. Am J Physiol Heart Circ – Professor Nigel Bunnett, (USA) Physiol 2008; 294:H238-48. Donohoe M, Videler H, sildenafil cessation in patients 25_ Nichols WW, Denardo SJ, – Professor Arthur Christopoulos, in October 2009 featuring a number Sharon M, Robinson CV, with pulmonary hypertension. Wilkinson IB, McEniery CM, (Australia); of leading international, national and We would like to sincerely thank 4_ Blewitt ME, Gendrel AV, Pang Stock D. Stoichiometry and Vascular Health and Risk Cockcroft J, O’Rourke MF. the following companies for Z, Sparrow DB, Whitelaw Localization of the Stator Management 2008; 4:1111-13. Effects of arterial stiffness, – A/Professor Arthur Conigrave, VCCRI speakers. N, Craig JM, Apedaile A, Subunits E and Gin Thermus pulse wave velocity, and (Australia) supporting our symposiums. Hilton DJ, Dunwoodie thermophilus H+-ATPase/ 19_ Kovacic JC, Moore J, wave reflection on the central International speakers Herbert A, Ma D, Boehm M, – Dr. Shaun Coughlin, (USA) Merck, Pfizer, addex, TGR SL, Brockdorff N, Kay GF, Synthase. J Biol Chem 2008; aortic pressure waveform. J Whitelaw E. SmcHD1, 283:2595-603. Graham RM. Endothelial Clin Hypertens (Greenwich) – Debbie Hay, (NZ) – Professor Stefanie Dimmeler BioSciences, Amgen, containing a structural- progenitor cells, angioblasts, 2008;10:295-303. 12_ Furtado MB, Solloway – Professor Graeme Henderson, (UK) (Germany) maintenance-of-chromosomes and angiogenesis--old terms GlaxoSmithKline, Biolab, Beckman MJ, Franklin V, Costa MW, hinge domain, has a critical reconsidered from a current 26_ O’Rourke MF, Adji A. Basis for – Dr. Brian Kobilka, (USA) – Professor Antoon Moorman Coulter, Perkin Elmer, AstraZeneca, Biben B, Wolstein O, Preis role in X inactivation. Nat perspective. Trends Cardiovasc use of central blood pressure (Netherlands) JI, Sparrow DB, Saga Y, – Professor Tsutomu Kouyama (Japan) Mar Research; Wyeth, Bristol- Genet. 2008; 40:663-9. Med 2008; 18:45-51. measurement in office clinical – Professor Shoumo Bhattacharya Dunwoodie SL, Robertson practice. J Am Soc Hypertens – Dr. Laurence Miller, (USA) Myers Squibb, GE Healthcare, EJ, Tam PPL, Harvey RP. 20_ Kovacic JC, Macdonald PS, (UK) 5_ Bryson-Richardson RJ, 2008;2:28-38. – Mr. Klaus Mohr, (Germany) Roche, Discoverx, Prism, Pathtech, Currie PD. The genetics of (2008). BMP/SMAD1 Feneley MP, Muller DWM, – Dr. Rama Ranganthan, (USA) – Professor Brian Black (USA) KI Scientific, Bioline, British vertebrate myogenesis. Nat signalling sets a threshold for Freund J, Dodds A, Milliken 27_ O’Rourke MF, Avolio AP. – A/Professor Vincent Christoffels Rev Genet. 2008; (8):632-46. the left/right pathway in lateral S, Tao H, Itescu S, Moore J, Arterial transfer functions: – Gebhard Franz Xaver Schertler Pharmacological Society, John plate mesoderm and limits Ma D, Graham RM. Safety background, applications and – A/Professor Gunnar Schulte, (Netherlands); Morris Scientific, Rigaku, Meeco, 6_ Butt AJ, Sergio CM, Inman availability of SMAD4. Genes and efficacy of consecutive reservations. J Hypertens (Sweden) – Dr. Rob Doughty (NZ); Eppendorf, Bayer HealthCare, CK, Anderson LR, McNeil CM, Dev 2008; 22:3037-49. cycles of granulocyte-colony 2008; 26:8-10. Russell AJ, Nousch M, Preiss stimulating factor, and an – Roger Summers, (Australia) – Dr. Nicola Hiemann (Germany); MACs, Genesearch, Schering- 13_ George RA, Smith TD, T, Biankin AV, Sutherland RL, intracoronary CD133+ cell 28_ O’Rourke MF, Hirata K. Callaghan S, Hardman – A/Professor Roger Sunahara, (USA) – Professor Ahsan Husain (USA); Plough, Quantum Scientific, Musgrove EA. The estrogen infusion in patients with Analysis of Carotid and L, Pierides C, Horaitis O, – Dr. Robert Kelly (France); and c-Myc target gene chronic refractory ischemic Ophthalmic Flow Velocity – Celine Valant, (Australia) Millipore, Australian Stem Cell Wouters MA, Cotton RG. HSPC111 is over-expressed in heart disease: the Gain I trial. Waveforms. Hypertension – Dr. Mark von Zastrow, (USA). – A/Professor Anne Moon (USA); Centre, NGED, Sapphire Bioscience, Response to Stenson et al on breast cancer and associated Am Heart J 2008;156:954-63. 2008; 51:e18. – Professor Nadia Rosenthal the review of general mutation – Professor Richard Henderson, SDR Clinical Technology, RISS, with poor patient outcome. (Italy/UK/Australia); databases. J Med Genet. 21_ Li M, Naqvi N, Yahiro E, 29_ O’Rourke MF, Safar ME. MRC Laboratory of Molecular Janssen-Cilag, International Society Breast Cancer Res. 2008; 2008; 45:319-20. Methods for transfer function – Richard G Smith (USA). 10:R28. Liu K, Powell PC, Bradley Biology, Cambridge, UK delivered of Developmental Biologists, ARMI, WE, Martin DI, Graham assessment. J Hypertens – Professor Andreas Zeiher 14_ George RA, Smith TD, 2008; 26:377-78. the Princesses’ Lecture speaking Solvay Pharmaceuticals, Scisense, 7_ Chen Y, Doughman YQ, GuS, Callaghan S, Hardman RM, Dell’italia LJ, Husain on the topic of ‘Structural changes (Germany), delivered the NSW Government Industry & Jarrell A, Aota S, Cvekl A, L, Pierides C, Horaitis O, A. c-kit Is Required for Princesses’ Lecture speaking on Watanabe M, Dunwoodie SL, Wouters MA, Cotton RG. Cardiomyocyte Terminal underlying function in 7-helix Investment, Heart Repair, Novartis, Johnson RS, van Heyningen V, Differentiation. Circ Res 2008 ‘Regeneration therapies for the General mutation databases: membrane proteins including SynCardia, Alphapharm, Heart Ware, Kleinjan DA, Beebe DC, Yang analysis and review. J Med 102:677-85. GPCRs’. failing heart’. Servier and Actelion. YC. Cited2 is required for the Genet. 2008; 45:65-70.
48_The VCCRI Annual Report 08/09 49_The VCCRI Annual Report 08/09 Publications 2008 CONT Publications 2008 CONT
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30_ O’Tuathaigh CM, O’Connor 37_ Riek RP, Finch AA, Begg 44_ Xu B, Qu X, Gu S, Doughman Commentaries & Editorials artery disease extent and Book Chapters AM, O’Sullivan GJ, Lai GE, Graham RM. Wide YQ, Watanabe M, Dunwoodie severity by Hope et al”. J D, Harvey R, Croke DT, turn diversity in protein SL, Yang YC. Cited2 is required 3_ Trounsen A, Harvey RP. “A Hypertens 2008;26:377-3783 17_ Turnpenny, PD, Kusumi, Waddington JL. Disruption transmembrane helices - for fetal lung maturation. Dev critical time for stem cell [Letter to the editor] K, Dunwoodie SL. to social dyadic interactions implications for G-protein Biol. 2008; 317:95-105. research in Australia” Cell DLL3, MESP2, LFNG and but not emotional/anxiety- coupled receptor and other Stem Cell 2008; 2:118-22. 14_ O’Rourke MF, Safar ME. spondylocostal dysostosis; related behaviour in mice with polytopic membrane protein 45_ Yadava RS, Frenzel-McCardell Methods for transfer function MIM 277300. In Inborn 4_ O’Rourke MF, Avolio AP. heterozygous ‘knockout’ of structure and function. Mol CD, Yu Q, Srinivasan V, Tucker assessment. J Hypertens. Errors of Development: The Arterial transfer function: the schizophrenia risk gene Pharmacol 2008 73:1092-104. AL, Puymirat J, Thornton 2008; 26:377-8; 378-9. Molecular Basis of Clinical background, applications, neuregulin-1. Progress in CA, Prall OW, Harvey [author reply] Disorders and Morphogenesis. reservations. J Hypertens Neuro-Psychopharmacology 38_ Strange G, Keogh A, RP, Mahadevan MS. RNA 2nd edition. Oxford University 2008; 26:4-5 [invited 15_ O’Rourke MF. How stiffening & Biological Psychiatry 2008; Williams T, Wlodarcyzk toxicity in myotonic muscular Press, Oxford, UK 2007 (In commentary]. of the aorta and elastic 32:462-6. J, McNeil K, Gabbay E. dystrophy induces NKX2- press). Bosentan therapy in patients 5 expression. Nat Genet arteries leads to compromised 5_ O’Rourke MF, Safar ME. 31_ Palmer BM, Wang Y, with pulmonary arterial 2008;40:61-8. coronary flow. [editorial] Heart 18_ Humphreys DT, Westman BJ, “Arterial pulse wave velocity Teekakirikul P, Hinson JT, hypertension: the relationship 2008; 94:690-1. Martin DIK, Preiss T. Inhibition but not augmentation index Fatkin D, Strouse S, Vanburen between improvements in Book Research of translation initiation a by is associated with coronary 16_ O’Rourke MF, O’Rourke P, Seidman CE, Seidman JG, 6 minute walk distance and a miRNA. In: Appasani K, 1_ Larson WJ (Harvey RP artery disease extent and J, Fansworth A. Aortic Maughan DW. Myofilament quality of life. Respirology ed. MicroRNAs: From Basic contributing Ed) Human severity by Hope et al”. J dimensions and stiffness in mechanical performance is 2008;13:5:674-82. Science to Disease Biology. Embryology (Forth Edition), Hypertens 2008; 26:377-3783 normal man. J Am Coll Cardiol enhanced by R403Q myosin Cambridge, UK: Cambridge Churchill Livingstone Inc., [Letter to the editor]. Imag 2008;1:749-51. (editorial) in mouse myocardium 39_ Sparrow DB, Guillén-Navarro University Press, 2008; 85- E, Fatkin D, Dunwoodie New York. [In Press, expected independent of sex. Am J 6_ O’Rourke MF. How stiffening Invited Reviews 101. SL. (2008). Mutation of release date April 11th 2008]. Physiol Heart Circ Physiol of the aorta and elastic HAIRY-AND-ENHANCER- 19_ Muckenthaler M, Preiss 2008; 294:H1939-47. Book & Meeting Reviews arteries leads to compromised 1_ Fatkin D, Otway R, Richmond OF-SPLIT-7 in Humans T. Mechanismen der coronary flow. (editorial) Heart Z. Genetics of dilated 32_ Pang CN, Krycer JR, Lek Causes Spondylocostal Translationskontrolle in 2_ Kovacic JC, Harvey RP, 2008;94:690-1. cardiomyopathy. Heart Failure A, Wilkins MR. Are protein Dysostosis. Hum Mol Genet Dimmeler S. Cardiovascular Clinics (in press-accepted Eukaryonten [Mechanisms complexes made of cores, 2008;17:3761-66. Regenerative Medicine: 7_ O’Rourke MF. How a stiff aorta 1/7/08). of translational control in modules and attachments? digging in for the long- leads to worse coronary flow. eukaryotes]. Chapter for the 40_ Sparrow DB, Boyle SC, Sams Proteomics. 2008 haul. Meeting Report, [editorial] Heart 2008 (in press). 2_ Cropley JE, Martin DIK, Suter book series “Molekulare RS, Mazuruk B, Zhang L, Feb;8(3):425-34. Cardiovascular Regenerative CM. Germline epimutation in Medizin [Molecular Moeckel GW, Dunwoodie SL, Medicine Symposium, 8_ O’Rourke MF, O’Rourke humans. Pharmacogenomics Medicine]”, volume 1: 33_ Pang CN, Wilkins MR. de Caestecker MP. Placental NIH-NHLBI, Bethesda, USA, J, Fansworth A. Aortic 2008; 9(12): 1861-1868 [Invited ”Grundlagen der Molekularen Online resources for the insufficiency causes renal October 1-2-2007. Cell Stem dimensions and stiffness in Review]. Medizin [Foundations of molecular contextualization of medullary dysplasia in Cited1 Cell 2008; 1:628-633. normal man. J Am Coll Cardiol molecular medicine]”, Editors: disease. Methods Mol Med. mutant mice. J Am Soc Imag 2008;1:749-51. (editorial) 3_ Cropley JE, Suter CM. An Ruckpaul K and Ganten 2008;141:287-308. Nephrol accepted 21/10/08 epigenetic basis for fetal D, 3rd completely revised 9_ O’Rourke MF. Brain programming. Highlights edition, Springer-Verlag, 41_ Teber ET, Liu JY, Ballouz 34_ Pang CN, Lin K, Wouters Microbleeds, Amyloid Plaques, 2008;16(1): 22-26 [Invited Berlin, Heidelberg, New York, S, Fatkin D, Wouters MA. MA, Heringa J, George RA. Intellectual Deterioration, Review]. London, Paris, Tokyo 2008; Comparison of automated Identifying foldable regions and Arterial Stiffness. p139-158. in protein sequence from the candidate gene prediction Hypertension 2008 51:e20. 4_ Martin DIK, Cropley JE, Suter hydrophobic signal. Nucleic systems using genes CM. Environmental influence 20_ Chapman G, Dunwoodie Acids Res 2008;36:578-88. implicated in type 2 diabetes 10_ O’Rourke MF, Safar ME. Book on epigenetic inheritance at the SL. Role of Delta-like-3 in by genome-wide association on Central Arterial Pressure. Avy allele. Nutrition Reviews mammalian somitogenesis 35_ Perrin, MJ, Kuchel, PW, studies. BMC Bioinformatics Laurent S, Cockcroft J (eds) 2008;66: S12-S14 [Invited and vertebral column Campbell, TJ, Vandenberg, 2008;10(Suppl 1): S69 Review]. formation. pp 95-112. In 11_ O’Rourke MF. Letter to the JI. Drug binding to the (IF=3.493) Somitogenesis (Advances editor “Brain microbleeds, 5_ Nichols WW, O’Rourke MF. inactivated state is necessary in Experimental Medicine 42_ Weber T, O’Rourke amyloid plaques, intellectual The life and times of Donald A but not sufficient for high and Biology, Vol.638, eds. MF, Ammer M, Kvas E, deterioration and arterial McDonald. Artery Research affinity binding to Human M Maroto and NV Whittock) Punzengruber C. Arterial stiffness”. Hypertension 2008; 2008;2:1-8. (review) Ether-a` -go-go-Related Gene Landes Bioscience and Channels. Mol Pharmacol stiffness and arterial wave 51:e20. 6_ O’Rourke MF, Hashimoto Springer Science+Business 2008;74:1443-52. reflections are associated J. Arterial stiffness: a Media (2008). IF = na (na) with systolic and diastolic 12_ O’Rourke MF, Hirata K. “Analysis of carotid and modifiable cardiovascular risk 36_ Perrin MJ, Subbiah RN, function in patients with 21_ O’Rourke MF, Safar ME. ophthalmic flow velocity factor? J Cardiopulmonary Vandenberg JI, Hill AP. normal ejection fraction. Am J Foreword. In: Laurent S, waveforms”. Hypertension Rehabilitation and Prevention Human ether-a-go-go related Hypertens 2008;21:1194-202. Cockcroft J (eds). Central 2008; 51:e18. [Letter to the 2008; 8:225 -237. gene (hERG) K+ channels: aortic blood pressure. 43_ Woodcock EA, Du XJ, editor] function and dysfunction. Paris: Les Laboratoires Reichelt ME, Graham RM. Prog Biophys Mol Biol. Servier, 2008. 2008;98:137-48. Cardiac {alpha}1-adrenergic 13_ O’Rourke MF, Safar ME. drive in pathological “Arterial pulse wave velocity remodelling. Cardiovasc Res but not augmentation index 2008;77:452-62. is associated with coronary
50_The VCCRI Annual Report 08/09 51_The VCCRI Annual Report 08/09 Publications 2009 Publications 2009 CONT
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1_ Battle AR, Petrov E, Pal 9_ Dunwoodie SL. Reprint 17_ Hing AJ, Watson A, Hicks M, 24_ Maple-Brown LJ, Cunningham 32_ Romantsov T, Battle AR, 40_ Wouters MA, Fan SW, 6_ Vandenberg JI, Kuchel PW. 15_ Weber T, Ammer M, Rammer P, Martinac B. Rapid and of mutation of the Gao L, Faddy SC, McMahon J, Barry RE, Leylsey L, Hendel JL, Martinac B, Haworth NL. Disulfides as Proteins, membranes and M, Adji A, O’Rourke MF, improved reconstitution of fucose-specific beta1,3 AC, Kesteven SH, Wilson O’Rourke MF, Celermajer Wood JM. Protein localization redox switches: from molecular cells: the structure-function Wassertheurer S, Rosenkranz bacterial mechanosensitive cetylglucosaminyltransferase MK, Jansz P, Feneley MP, DS, O’Dea K. Impact of in Escherichia coli cells: mechanisms to functional nexus-ASB 2008. Eur Biophys S, Eber B. Noninvasive ion channel proteins MscS and LFNG results in abnormal Macdonald PS. Combining dyslipidaemia on arterial comparison of cytoplasmic significances. Antioxid Redox J. 2009;39:1. determination of carotid- MscL into liposomes using formation of the spine. cariporide with glyceryl structure and function in membrane proteins ProP, LacY, Signal. 2009. femoral pulse wave velocity a modified sucrose method. Biochim Biophys Acta. 2009; trinitrate optimises cardiac urban Indigenous Australians. ProW, AqpZ, MscS, and MscL. Reviews depends critically on preservation during porcine J Bacteriol 2009. 41_ Xaymardan M, Cimini M, Fazel FEBS Lett. 2009; 583:407-12. 1792:862-73. Atherosclerosis. 2009; 7_ Dunwoodie SL. Mutation of assessment of travel distance: heart transplantation. American 202:248-54. S, Weisel RD, Lu WY, Martin a comparison with invasive 33_ Sewell W, Sparrow DB, Smith the fucose-specific beta1,3 2_ Beilharz TH, Preiss 10_ Dunwoodie SL. The role of Journal of Transplantation U, Harvey RP, Li RK. c-Kit measurement. J Hypertens. AJ, Gonzalez DM, Rappaport cetylglucosaminyltransferase T. Transcriptome-wide hypoxia in development of the 2009; 9: 1-9. 25_ Matsui Y, Eguchi K, O’Rourke function is necessary for in 2009; 27:1624-30. measurement of mRNA Mammalian embryo. Dev Cell. MF, Ishikawa J, Miyashita H, EF, Dunwoodie SL, Kusumi vitro myogenic differentiation LFNG results in abnormal polyadenylation state. Methods 2009 17:755-73. 18_ Huang YH, Colgrave ML, Daly Shimada K, Kario K. Differential K. Cyclical expression of the of bone marrow hematopoietic formation of the spine. 16_ Safar ME, O’Rourke MF. The 2009; 48:294-300. NL, Keleshian A, Martinac B, effects between a calcium Notch/Wnt regulator Nrarp cells. Stem Cells. 2009; Biochim Biophys Acta. 2009; brachial-ankle pulse wave 11_ Du H, Davidson PM, Everett B, Craik DJ. The biological activity channel blocker and a diuretic requires modulation by Dll3 in 27:1911-20. 1792:100-11. velocity. J Hypertens. 2009; 3_ Beilharz TH, Humphreys Salamonson Y, Zecchin R, Rolley of the prototypic cyclotide kalata when used in combination with somitogenesis. Dev Biol 2009; 1960-1961. DT, Clancy JL, Thermann JX, Newton PJ, Macdonald b1 is modulated by the formation 329:400-9. 42_ Zdanowicz A, Thermann 8_ Dunwoodie SL. The role of angiotensin II receptor blocker Notch in patterning the human R, Martin DIK, Hentze MW, PS. Assessment of a Self- of multimeric pores. J Biol Chem. on central aortic pressure R, Kowalska J, Jemielity 17_ Sparrow DB, Boyle SC, Sams Preiss T. MicroRNA-mediated administered Adapted 6-Minute 2009; 284:20699-707. 34_ Suter CM, Martin DI. J, Duncan K, Preiss T, vertebral column. Curr Opin RS, Mazuruk B, Zhang L, in hypertensive patients. Paramutation: the tip of an messenger RNA deadenylation Walk Test. J Cardiopulm Rehabil Darzynkiewicz E, Hentze MW. Genet Dev. 2009; 19:329-37. Moeckel GW, Dunwoodie SL, Hypertension. 2009; 54:716-23. epigenetic iceberg? Trends contributes to translational Prev. 2009. 19_ Jacoby AS, Busch-Nentwich Drosophila miR2 primarily de Caestecker MP. Placental Genet. 2009. 9_ Giampietro PF, Dunwoodie repression in mammalian cells. E, Bryson-Richardson RJ, 26_ Naqvi N, Li M, Yahiro E, targets the m7GpppN cap insufficiency associated with Hall TE, Berger J, Berger S, SL, Kusumi K, Pourquié O, PLoS One. 2009; 4:e6783. 12_ Esposito G, Grutter G, Drago Graham RM, Husain A. structure for translational loss of Cited1 causes renal Sonntag C, Sachs C, Geisler 35_ Tatsukawa H, Fukaya Y, Tassy O, Offiah AC, Cornier AS, F, Costa MW, De Santis A, Insights into the characteristics repression. Mol Cell. 2009; medullary dysplasia. J A Soc R, Stemple DL, Currie PD. The Frampton G, Martinez- Alman BA, Blank RD, Raggio 4_ Carballo S, Robinson P, Otway Bosco G, Marino B, Bellacchio of mammalian cardiomyocyte 35:881-8. Nephrol 2009; 4:777-86. zebrafish dystrophic mutant Fuentes A, Suzuki K, Kuo TF, CL, Glurich I, Turnpenny PD. R, Fatkin D, Jongbloed J, E, Lepri F, Harvey RP, Sarkozy terminal differentiation shown softy maintains muscle fibre Nagatsuma K, Shimokado K, Progress in the Understanding de Jonge N, Blair E, van A, Dallapiccola B. Molecular through the study of mice with 43_ Zhao J, Hill AP, Varghese Letters to the Editor viability despite basement Okuno M, Wu J, Iismaa S, of the Genetic Etiology of Tintelen JP, Redwood C, analysis of PRKAG2, LAMP2, a dysfunctional c-Kit. Pediatr A, Cooper AA, Swan H, membrane rupture and muscle Matsuura T, Tsukamoto H, Zern Vertebral Segmentation 1_ Kovacic JC, Macdonald P, Watkins H. Identification and and NKX2-5 genes in a cohort Cardiol. 2009; 30:651-8. MA, Graham RM, Kojima S. Laitinen-Forsblom PJ, Rees functional characterisation of 125 patients with accessory detachment. Development MI, Skinner JR, Campbell TJ, Disorders in Humans. Ann N Y Feneley MP, Graham RM. 2009 136:3367-3376. Role of Transglutaminase 2 in Acad Sci. 2009; 1151:38-67. Granulocyte-colony stimulating of a novel disease gene in atrioventricular connection. 27_ Ng LJ, Cropley JE, Pickett liver injury via cross-linking and Vandenberg JI. Not all hERG autosomal dominant dilated Am J Med Genet A. 2009; HA, Reddel RR Suter pore domain mutations have factor in ischemic heart 20_ Ju P, Pages G, Riek RP, silencing of transcription factor 10_ Iismaa SE, Mearns B, disease: throwing stones from cardiomyopathy. Circ Res 149A:1574-7. CM. Telomerase activity is Sp. Gastroenterology 2009; a severe phenotype: G584S Chen PC, Torres AM, Bansal Lorand L, Graham RM. glass houses. Am Heart J. 2009; 105:375-82. associated with an increase 136:1783-95. has an inactivation gating 13_ Fan SW, George RA, Haworth PS, Kuyucak S, Kuchel PW, Transglutaminases and 2009; 27:157:e39; author reply Vandenberg JI. The pore in DNA methylation at the defect with mild phenotype Disease: Lessons from 5_ Chen Y, Carlson EC, Chen NL, Feng LL, Liu JY, Wouters 36_ Teber ET, Liu JY, Ballouz e41. domain outer helix contributes proximal subtelomere and compared to G572S which has Genetically-Engineered ZY, Hamik A, Jain MK, MA. Conformational changes S, Fatkin D, Wouters MA. to both activation and a reduction in telomeric a dominant negative trafficking Mouse Models and Inherited Dunwoodie SL, Yang YC. in redox pairs of protein Comparison of automated To be used for next inactivation of the hERG K+ transcription. (2009) Nucleic defect and a severe phenotype. Conditional Deletion of Cited2 structures. Protein Sci 2009; candidate gene prediction Disorders. Invited review. channel. J Biol Chem. 2009; Acids Res 2009; 37:1152-9. J Cardiovasc Electrophysiol Board Meeting Results in Defective Corneal 18:1745-1765. systems using genes Physiol Rev 2009; 89:991- 284: 1000-8. 2009; 8:923-30. Epithelial Morphogenesis and 28_ Otton J, Hayward CS, Keogh implicated in type 2 diabetes 1023. Williams H, Pease RJ, Newell LM, 14_ Foo D, Walker BD, Kuchar DL, Maintenance. Dev Biol. 2009; 21_ Kurz M, Iturbe-Ormaetxe AM, Glanville AR, Macdonald by genome-wide association Commentaries & Editorials Cordell PA, Graham RM, Kearney Thorburn CW, Tay A, Hayward 11_ Newton PJ, Betihavas V, 334:243-52. I, Jarrott R, Shouldice PS. Everolimus associated studies. BMC Bioinformatics MT, Jackson CL, G rant PJ. Effect of CS, Macdonald P, Keogh A, 1_ Grossfeld P, Ye M, Harvey Macdonald P. The role of SR, Wouters MA, Frei P, pneumonitis in 3 heart 2009; 10 Suppl 1:S69. transglutaminase 2 (TG2) deficiency Kotlyar E, Spratt P, Jansz P. Left R. Hypoplastic left heart b-type natriuretic peptide in 6_ Chandar S, Yeo LS, Leimena Glockshuber R, Oneill S, Heras transplant recipients. J Heart on atherosclerotic plaque stability 37_ Tomiyama K, O’Tuathaigh CM, heart failure management. Aust C, Tan JC, Xiao XH, Nikolova- ventricular mechanical assist B, Martin J. Structural and Lung Transplantation 2009; syndrome: new genetic in the apolipoprotein E deficient O’Sullivan GJ, Kinsella A, Lai Crit Care. 2009; 22:117-23. Krstevski V, Yasuoka Y, devices and cardiac device functional characterization of 28:104-106. insights. J Am Coll Cardiol. mouse. Atherosclerosis 2009. D, Harvey RP, Tighe O, Croke Gardiner-Garden M, Wu J, interactions: an observational the oxidoreductase α-DsbA1 2009 24;53:1072-4 12_ O’Rourke MF, Hayward CS. DT, Koshikawa N, Waddington Kesteven S, Karlsdotter case series. Pacing Clin from wolbachia pipientis. 29_ O’Rourke MF. Time domain The pulse of cardiology: quo Romantsov T, Battle AR, Hendel JL. Phenotype of spontaneous 2_ Nichols WW, O’Rourke MF. L, Natarajan S, Carlton A, Electrophysiol. 2009; 32:879- Antioxid Redox Signal. 2009. analysis of the arterial pulse in vadis? J Am Coll Cardiol. 2009; JL, Martinac B, Wood JM. Protein orofacial dyskinesia in Aortic pulse wave velocity, Rainer S, Feneley MP, Fatkin 87. clinical medicine. Med Biol Eng 54:714 -7. localization in Escherichia coli D. Effects of Mechanical 22_ Macindoe I, Glockner L, Comput. 2009; 47:119-29. neuregulin-1 ‘knockout’ mice. reflection site distance, cells: comparison of cytoplasmic Stress and Carvedilol in 15_ Ferdous A, Caprioli A, Iacovino Vukasin P, Stennard FA, Costa Prog Neuro-Psych Biol Psych and augmentation index. 13_ O’Rourke MF. How stiffening membrane proteins ProP, LacY, Lamin A/C-Deficient Dilated M, Martin CM, Morris J, MW, Harvey RP, Mackay JP, 30_ O’Rourke MF, Adji A. Central 2009; 33:330-3. Hypertension. 2009;53:e9; of the aorta and elastic arteries ProW, AqpZ, MscS, and MscL. J Richardson JA, Latif S, Pressure and Pulse Wave author reply. Cardiomyopathy. Circ Res. Sunde M. Conformational 38_ Traven A, Beilharz TH, Lo TL, leads to compromised coronary Bacteriol 2009. 2009 Hammer RE, Harvey RP, Olson stability and DNA binding Amplification in the Up Limb. flow. Heart. 2008; 94:690-1. EN, Kyba M, Garry DJ. Nkx2-5 Hypertension. Lueder F, Preiss T, Heierhorst 3_ O’Rourke MF, Safar ME. Chandar S, Yeo LS, Leimena specificity of the cardiac T-box J. The Ccr4-Pop2-NOT mRNA Cardiovascular risk in young 7_ Combes AN, Spiller CM, Harley transactivates the Ets-related transcription factor tbx20. J Mol 14_ O’Rourke MF, Hashimoto J. C, Tan JC, Xiao XH, Nikolova- 31_ Pages G, Torres AM, Ju P, Deadenylase contributes adults. J Hypertens. 2009; VR, Sinclair AH, Dunwoodie protein 71 gene and specifies Biol 2009; 12; 389:606-18. Arterial stiffness: a modifiable Krstevski V, Yasuoka Y, Gardiner- SL, Wilhelm D, Koopman P. an endothelial/endocardial fate Bansal PS, Alewood PF, Kuchel to septin organization in 27:1504-5; author reply 1505. cardiovascular risk factor? J Garden M, Wu J, Kesteven S, 23_ Macdiarmid JA, Amaro- PW, Vandenberg JI. Structure saccharomyces cerevisiae. Gonadal defects in Cited2 in the developing embryo. Proc 4_ O’Rourke MF, Weber T. Stroke Cardiopulm Rehabil Prev. 2008 Karlsdotter L, Natarajan S, Carlton Mugridge NB, Madrid-Weiss of the pore-helix of the hERG Genetics 2009; 182:955-66. -mutant mice indicate a role Natl Acad Sci U S A. 2009; risk and antihypertensive drug Jul-Aug; 28:225-37. A, Rainer S, Feneley MP, Fatkin D. for SF1 in both testis and ovary 106:814-9. J, Petti C, Sedliarou I, Wetzel K+ channel. Eur Biophys J. Effects of Mechanical Stress and 2009; 39:111-20. 39_ Williams H, Pease RJ, Newell therapy. J Hypertens. 2009; differentiation. Int J Dev Biol. S, Kochar K, Brahmbhatt V, LM, Cordell PA, Graham Carvedilol in Lamin A/C-Deficient 16_ Hurst AC, Gottlieb PA, 27:1505-6; author reply 1506-7. 2009. Phillips L, Stillman B, Graham RM, Kearney MT, Jackson Dilated Cardiomyopathy. Circ Res. Martinac B. Concentration RM, Brahmbhatt H. Sequential CL, G rant PJ. Effect of 5_ O’Rourke MF, Takazawa 2009 8_ Corte TJ, Wort SJ, Gatzoulis dependent effect of GsMTx4 treatment of drug-resistant transglutaminase 2 (TG2) K. Flawed Measurement MA, Macdonald P, Hansell on mechanosensitive channels tumors with targeted minicells deficiency on atherosclerotic of Brachial Tonometry for Dunwoodie SL. The role of hypoxia DM, Wells AU. of small conductance in E. coli containing siRNA or a cytotoxic plaque stability in the Calculating Aortic Pressure? in development of the Mammalian spheroplasts. Eur Biophys J. drug. Nature Biotech 2009; apolipoprotein E deficient Hypertension. 2009; 54:e131; embryo. Dev Cell. 2009 17:755-73. 2009; 38:415-25. 27;643-651. mouse. Atherosclerosis 2009. author reply e132.
52_The VCCRI Annual Report 08/09 53_The VCCRI Annual Report 08/09 FINANCE REPORT VCCRI SPOTLIGHT
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The memory of Des Renford will live Victor Chang Cardiac Research Institute Limited Des Renford Gala Day on in our hearts and through the Des A.B.N. 61 068 363 235 — Renford Chair of Heart Research. On the eve of the new millennium, Australia lost an icon and the $2009 $2008 Institute lost a dear friend – Des Renford, MBE, OHC. Des lived life to the fullest despite knowing Income that at any time his fight with heart disease might claim his life. He was Grants 10,592,617 10,518,509 an avid supporter of the Institute Fund Raising 4,358,749 2,668,125 and had a reputation for not wasting Des had spent many an hour at the time whilst he was recuperating Maroubra Aquatic Centre, which was Other 2,268,181 2,941,595 in hospital. Having had three open renamed the Des Renford Aquatic Total Income 17,219,547 16,128,229 heart surgeries and a transient Centre in his honour, so an annual stroke he spent his hospital days Gala Day at the pool for the last ten visiting fellow patients and selling years has helped raise the additional Expenses funds needed to fund the Chair with Victor Chang merchandise. 01 the help of Des and Michael’s friends Fundraising Events Expenses 425,289 617,126 To celebrate his life an all day tribute and Randwick Council. Operating and Overhead Expenses commencing with a swim-a-thon in a 25 metre, one lane purpose built Michael, not content with just the Salaries and related expenses 9,788,699 9,015,326 pool, erected on the old casino site Gala Day, has been the inspiration for Research Consumables 1,946,559 2,430,288 which at that time had been taken many other fundraisers to keep the over by Doltone House. Many of Des’ Chair viable. He not only swam across Building Fees 0 286,338 friends came along to swim in his the English Channel but has done the Repairs and Maintenance 60,511 173,566 honour - Murray Rose, John Devitt, Manhattan Island and Catalina Island 02 Barry Rodgers, Guy Leech, to name swims as well as many other local Other 3,049,821 2,745,513 just a few. As night fell, 600 guests challenges. Total Operating and Overhead Expenses 14,845,590 14,651,031 attended a black tie fundraiser to help We are very grateful to Michael, his raise money to establish the Des 15,270,879 15,268,157 lovely wife Vanessa and his friends Renford Chair of Heart Research at especially Errol and Gerry Goldberg, Total Expenses the VCCRI. $250,000 was raised that Tony Johnston, Baden Green, night which was put towards the $1.5 Surplus / (Deficit) Before Depreciation 1,948,668 860,072 Des’ Coffee Club friends, Randwick million needed to establish the Chair. Council and the staff at the Des 03 Depreciation 1,331,146 1,109,826 With $750,000 still to raise, Michael Renford Aquatic Centre for their Renford, Des’ youngest son, continued support and friendship. decided he would step into his Net Operating Surplus / (Deficit) 617,522 (249,754) The memory of Des Renford will live father’s shoes and take his place on in our hearts and through the Des on the VC Appeal Committee. Renford Chair of Heart Research.
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01 Des Renford 02 Face painting 03 Group entertainment 04 Children learning to swim
54_The VCCRI Annual Report 08/09 55_The VCCRI Annual Report 08/09 FUNDRAISING & FUCTIONS
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On behalf of everyone at the VCCRI, thank you to all of our donors for your continued support. This is your institute and its success over the past fifteen years is due to your faith in our research. 16 We hope you are proud of our achievements and we look forward to you working with us as try to unlock the mystery of heart disease.
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08 Crabfest; the celebrity Chefs 09 John Aloisi with Steven Lowy and Sr Elizabeth Dodds, RSC 10 Cooper Brothers Durack Stable 01 Golfers at the 2008 VC Golf Day at Opening Concord 11 2008 Steer Auction Royal Easter Show 02 Golfers at the 2008 VC Golf Day at 12 Heart to Heart Ball Concord 13 Artist George Ward with finishing 03 2009 Westfield Belconnen Golf Day touches to his painting 04 Executive Director Bob Graham 14 Guest of Honour at the 2009 Heart to with Lisa Curry-Kenny and Sonia Heart Ball Kruger at the 2008 Ball 15 Jim Redman with Confocal Microscope 05 Steve Quinn presenting cheque at the 2008 Ball 16 James Morrision performing at Heart to Heart Ball 06 2008 Hawkesbury Race Day 17 Scots College Pipes & Drums & Rhythm 07 Crabfest on Tap, 2009 Heart to Heart Ball 03 06 13 14
56_The VCCRI Annual Report 08/09 57_The VCCRI Annual Report 08/09 SCHOOL SCIENCE AWARDS VCCRI Limited Members
• • • • • • The Institute is extending its reach into the community for the good of science. Monique Ohanian, the Victor Chang The Mary Aikenhead The Trustees 2004 inaugural school science award — winner, remembers her excitement at Ministries Trustees winning the Award at Loyola Senior — High School, Mount Druitt. Mary Aikenhead Ministries was As a part of her prize Monique spent established by the Congregation a day at the Institute to see first-hand of Religious Sisters of Charity of the research being done. She later The Victor Chang School Science Australia to succeed to, and to carry did a week of work experience at Award program is directly in line on and expand, the various ministries the Institute, then a month in 2005 with one of the Institute’s major conducted by the Sisters of Charity Sister Linda Ferrington was Rowena McNally was born Richard Harpham lives in followed by 2 months in 2006 on a missions, namely the provision of of Australia. world-class training in biomedical born in Sydney and educated by in Papua New Guinea and Sydney. He has over 36 years Scholarship and in 2007 worked part- Mary Aikenhead Ministries was the Sisters of Charity and has attended primary school there. experience in the financial research and related sciences. The time whilst completing her degree – a granted canonical status as a public been engaged in the ministry of She completed her education services and banking industry Institute’s other major mission being The Victor Chang School Science Bachelor of Medical Science. Monique juridic person of pontifical right by education in various ways for the in Sydney and at All Hallows within Australia and overseas. to produce cutting-edge research, Awards are presented to Year 11 now works full time at the Institute the Congregation for Institutes of last thirty years. in Brisbane, where she now The bulk of his career has and to facilitate the rapid translation students who are selected by their resides. Her qualifications in been in commercial banking and recently not only completed her Consecrated Life and Societies of Linda was a Trustee of Sisters of of research advances to patient care. school as having excelled in their law entitle her to practice in the with Citibank, Westpac and Honours degree with the Institute but Apostolic Life on 25 April 2008 and Charity Australia for six years while science studies during the year. Federal Court and the High Court St. George. He attended graduated with First Class Honours Since the awards were first officially established on July 1, 2009. a member of the Congregational of Australia. She is an accredited St. Ignatius College, Riverview Awardees are presented with a Council and has been involved in and received the University Medal presented in 2004 we now have mediator, arbitrator and and is a graduate of the framed Certificate-of-Achievement Under Mary Aikenhead Ministries Governance since 1992. She has from the University of Western Sydney well over 100 schools participating construction industry adjudicator. University of Queensland. at presentation ceremonies and the many ministries that have served on Education and Health (Hawkesbury Campus). from Campbelltown, Bankstown, She is a director of St. Vincent’s & Richard has been involved are given the opportunity to visit been established and developed Boards with the Congregation and Holy Spirit Health. with the Sisters of Charity Blacktown and Penrith areas. In 2010 the wider Church. Linda is the Institute for some hands on by the Sisters of Charity, will be for well over 10 years serving we anticipate them being introduced Director of the Institute for experience. governed by a group of Trustees, on a number of boards and to schools in Wollongong and Mission which is responsible committees relating to consisting initially of members of the for Adult Faith Formation in surrounding areas. The Institute is extending its reach health, education and the Congregation and lay colleagues. the Diocese of Parramatta. into the community for the good of Congregation’s financial science, and it is hoped that one day Mary Aikenhead Ministries will administration. this will benefit the lives and health of invite Sisters of Charity of Australia all Australians. to contribute their presence, experience, involvement, wisdom and spirituality for as long as Sisters are willing and able.
Sister Elizabeth Dodds rsc David Robinson resides in has twelve years experience Sydney. He was educated by 01 as a Trustee of the Sisters of the Sisters of Charity and the Charity of Australia serving as Christian Brothers and is a a Congregational Councillor graduate of the University of and in the immediate past as Sydney. David is a Chartered Congregational Leader. She Accountant and a Company is a graduate of the University Director. He has been involved 03 of Sydney and the Australian with the Sisters of Charity since Catholic University. Her ministry 1989, serving on education experience includes education, boards and other committees governance and administration, and is currently serving on both education and 01 Monique Ohanian health boards within the Sisters Chairman of the Congregation’s 02 Blacktown presentation of Charity and other Religious Advisory Finance Committee. 03 Professor Graham congratulating Institutes and as a member a student at Bankstown of the Stewardship Board of 04 Penrith presentation Catholic Health Australia. 02 04
58_The VCCRI Annual Report 08/09 59_The VCCRI Annual Report 08/09 VCCRI Supporters
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KILOMETRES PER DAY IN WHICH THE BLOOD TRAVELS AROUND THE BODY 19,000 KILOMETRES
1 LIFE CLAIMED EVERY 10 Minutes AUSTRALIAN STROKES PER YEAR 70% OF HEART ATTACKS HAVE NO WARNING
AMOUNT OF WATER IN BLOOD FIRST HEART TRANSPLANT 78% 40, 1968 LIFE EXPECTANCY OF WOMEN FIRST HEART LUNG TRANSPLANT 82.0 1986 60_The VCCRI Annual Report 08/09 Designed and produced by stopedit.com.au 000 HOWARD HUGHES INSTITUTE, CANADA
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