IMPAC T REPORT 2018

Finding cures for cardiovascular disease through medical research Heart attacks + stroke

Stem cells

Pregnancy + birth defects

Life-saving Inherited heart disease research

Heart transplants

Genetic analysis

Cardiac arrests ANNUAL REVIEW 2018 01

No.1 Cardiovascular disease is the number one cause of death globally Contents

SUBJECT PAGE NO.

About Us 02 The Problem 03 PREVENTING HEARTBREAK William’s Story 04 Chairman’s Report 06 42/wk 42 babies are born Executive Director’s Report 10 with a heart defect PREVENTING HEARTBREAK Liza’s Story 12 every week Organisational Structure 13 Board of Directors 14 The Power of Discovery 16 THE SOLUTION Seeing really is believing 18 THE SOLUTION Our ace of hearts 22 THE SOLUTION Sequence of success 26 Research Divisions 30 Victor Chang Cardiac Research Institute Innovation Centre 32 PREVENTING HEARTBREAK Fred’s Story 34 Statement of Income and Expenditure 35 Health Check Booth 36 Cover image. In a recent paper published in the Sohn Hearts & Minds prestigious journal Nature, Dr Gonzalo Del Monte Nieto, Investment Leaders Conference 38 Professor Richard Harvey and their colleagues put forward a new model for how the pumping chambers of the heart Achievements and Awards 40 form in the developing embryo. Central to this model is how fibrous extracellular material, called extracellular matrix, 42 Fundraising Events organises the growth of cardiac muscle cells, necessary for Supporters and Acknowledgments 44 proper heart function. This image is a view from inside the ventricles of the main pumping chamber of a developing Support Life-Saving Heart Research 49 heart, with cardiac muscle shown in red, and the extracellular matrix shown in blue. In normal (wild type – left) hearts, you can see the extracellular matrix material organised into a series of domes separated at their base by threads of cardiac muscle. However, the growth of the cardiac muscle occurs mostly within the matrix domes. In hearts that carry a defect in the gene for Neuregulin 1 (Nrg1tm/tm – right), responsible for the synthesis of the extracellular matrix, the domes do not form well and the underlying muscle becomes exposed and does not grow properly, severely affecting heart function. This study will provide a new framework for understanding heart development and the causation of congenital heart disease. Read more about these findings on page 16. 02 VICTOR CHANG CARDIAC RESEARCH INSTITUTE

About Us

The Victor Chang Cardiac Research Institute is dedicated to finding cures for cardiovascular disease through world class medical research.

Renowned for the quality of its breakthroughs, the Victor Chang Cardiac Research Institute uses innovative transplantation techniques and conducts complex molecular and genetic analysis. It integrates advanced stem cell research, regenerative medicine and bio‑engineering, to discover better ways of diagnosing, treating and ultimately preventing the onset of heart disease.

Our Mission Our Values Our 2018 Statistics

The relief of pain Excellence: 320 and suffering, and to achieve excellence in research researchers and staff the promotion of Creativity: 114 wellbeing, through an to demonstrate creativity in the scientific publications pursuit of scientific discovery understanding of the 23 Integrity: laboratories fundamental mechanisms to act with honesty, integrity 80 and fairness at all times of cardiovascular biology seminars hosted at the Victor in health and disease. Impact: Chang Cardiac Research Institute to undertake research that has 10,035 significant impact and makes people tested by the a difference Health Check Booth Teamwork: 800 to promote a sense of teamwork people toured the Victor Chang and collegiality amongst staff Cardiac Research Institute and collaborators ANNUAL REVIEW 2018 03

The Problem No.1 12min Heart disease is the One Australian dies from single biggest killer cardiovascular disease of Australians every 12 minutes Cardiovascular disease is the leading cause of death globally. It claims the life of one Australian every 12 minutes and can affect anyone regardless of age or gender. Labelled Australia’s most expensive disease, it currently costs more than $12 billion in healthcare expenditure per year. $12bn 10min The Victor Chang Cardiac Research Cardiovascular disease One Australian costs the economy suffers a heart attack Institute is a key part of a global up to $12 billion a year every 10 minutes community working towards making a difference for the 4.2 million Australians living with effects of heart disease. Our job doesn’t stop until we find a cure to end all suffering.

3× 22/day Three times more women Heart disease kills die of heart disease 22 Australian women than breast cancer every day

1/500 40/day One in 500 people Forty Australians are affected by die of a heart rhythm cardiomyopathy disorder every day Preventing Heartbreak: William’s Story

04 VICTOR CHANG CARDIAC RESEARCH INSTITUTE

Preventing Heartbreak At the Victor Chang Cardiac Research Institute, we’re striving towards transforming the lives of millions of people living with heart disease. Every day we search for answers. Answers for the people living with its devastating effects. We are striving to solve the unsolved.

William’s Story

“Our introduction to the world of heart disease JULIA, WILLIAM’S MUM was sudden, unexpected and truly terrifying. It was August 2015 and our little boy, William, We are so grateful had been unwell with suspected gastro. But he wasn’t recovering, so we took him to a GP. We to the incredible were told to take him home and give him Panadol doctors and because the doctor thought he had a virus. Six hours surgeons we have, later we were in emergency. William was actually in end-stage heart failure, with a diagnosis of and how modern dilated cardiomyopathy. medicine has given Everything was surreal. The next day we were our son a future. told William was in a critical state and that he’d be put on ECMO, or short-term life support, and then most likely be given a ventricular assist device until a heart transplant became our only option. We remember it was midnight and we were sitting with two cardiologists being told the news … we just sat there thinking ‘how did this happen? How did we not know?’

Research Update

Professor Diane Fatkin and her team of researchers are using cutting‑edge technology, including next generation sequencing techniques, to find genetic variants in families with dilated cardiomyopathy. Professor Fatkin and her team are hoping to identify new approaches that can assist in the diagnosis, treatment and prevention of inherited heart disease. ANNUAL REVIEW 2018 05

129 In 2018, 129 Australians received a life- saving heart  William with his brother, Mason, dad, Tristan, mum, Julia and sister, Eliza William recovering after his heart transplant

transplant a. b.

Now we understand the grunting breaths, the puffiness, the excessive sweating, the dry cough … they were all signs of heart failure. We couldn’t believe it. Just that morning, William had been diving off the couch like any other crazy, unstoppable 17-month-old baby. We spent just over six months in hospital – four-and-a-half months waiting for a heart transplant and another two-and-a-half months recovering after the transplant. It was incredibly tough on our family. Our life is now complicated and full of anxieties. But William is alive. And we know each day is a blessing.”

b

Research Update

Professor Peter Macdonald’s laboratory is pioneering a new era a of heart transplantation, which is expected to be implemented around the globe. His team is working on novel methods of donor heart preservation with the hope of extending this life-saving treatment to more Australians. 06 VICTOR CHANG CARDIAC RESEARCH INSTITUTE

Chairman’s Report

Perseverance is something our scientists have in abundance. Not to mention endurance and imagination.

It takes years of pragmatic, methodical and meticulous investigation to make a life-changing breakthrough in heart research. That’s the commitment the scientists at the Victor Chang Cardiac Research Institute make. These gifted and passionate men and women have devoted their lives to help bring

us closer to the future they imagine. The research A future in which no baby will be born breakthroughs continue with a heart defect and there will be Through this ongoing work, again better and more effective cures for this year our scientists have made discoveries that will change the cardiovascular disease. lives of people around the globe. One such landmark breakthrough was accomplished by Professor Richard Harvey and his team, shedding new light on heart defects in babies. Our hope is that this groundbreaking research will provide insights into how we might coax the human heart to regenerate its own cells. Imagine that. And then imagine the possibilities to come from the work of Professor Roland Stocker and his team, who have developed the first non-invasive test to diagnose those likely to suffer a heart attack. ANNUAL REVIEW 2018 07

c Chairman Grounds, Matthew c.

Further still, Professor Bob Graham, The NSW Government recognises our founding Executive Director, the cost of cardiovascular disease and his team, in collaboration Our hope is that on society. We have been fortunate with international colleagues, to receive $25 million from the discovered the first genetic marker this groundbreaking NSW Government to develop the of spontaneous coronary artery research will provide world class Victor Chang Cardiac dissection or SCAD, which is insights into how Research Institute Innovation killing otherwise fit women in Centre. Most recently, the NSW their 40s and 50s. we might coax Government has made a game- the human heart changing $150 million investment NSW Government support to regenerate in cardiovascular research which is While the advances our scientists set to revolutionise the treatment make are genuinely life-changing its own cells. and prevention of heart disease (as detailed in the Executive Imagine that. and stroke. Over the next decade, Director’s Report), cardiovascular NSW medical research institutes, disease continues to wreak havoc universities and hospitals will in our community. It claims the life benefit from this generous of one Australian every 12 minutes; contribution. We are delighted every four hours a baby in this that the NSW Government country is born with a heart defect, is being so supportive of our and it kills three times more women outstanding scientists. than breast cancer. Astonishingly, cardiovascular disease costs Australia $12 billion annually in healthcare expenditure. 08 VICTOR CHANG CARDIAC RESEARCH INSTITUTE

Hearts and Minds HM1 is an ingenious idea from Conference and Fund fellow board member, Hamish The need for We are grateful to again be Douglass, and my long-time beneficiaries of the third Sohn colleague at UBS, Guy Fowler. philanthropic Hearts and Minds Investment The initial public offering support of our Leaders Conference, in which was a great success, raising cardiovascular Australia’s and the world’s $500 million and will be a major top fund managers share contributor of funding for medical researchers their best investment ideas research both at the Institute has never been as a contribution to medical and other medical research greater. With research. The conference goes organisations around Australia. from strength to strength with A very big thank you to you on our side almost 1,000 people attending all the participating fund in Melbourne in November. the possibilities managers and in particular are endless. Building on the success of the the Core Fund Managers, conference, in a world first, Caledonia Investments, Cooper we have established a listed Investors, Magellan Financial investment vehicle which has, Group, Paradice Investment as one of its objectives, the Management and Regal Funds generation of revenue to benefit Management, together with the medical research. Known as board of HM1, all of whom are Hearts and Minds Investments donating their services. Limited (ASX: HM1), this vehicle provides investors with exposure to the investment ideas presented at the conference, plus a few others. The fund managers provide their ideas pro bono and in lieu of management fees, and the fund makes a donation to medical research equal to 1.5% of the fund annually. ANNUAL REVIEW 2018 09

The Institute Congratulations to all our Bob would be the first to tell It has certainly been a busy and board members and faculty, you that research is a long- successful year for the Institute, whose unwavering commitment distance journey, and that not only on the research front is exemplary. an endurance runner needs but also from a finance and an incredible support crew, And, a special mention of administration perspective. prepared to go the distance Professor Graham, who has None of our successes would be with them. I know he joins me fostered excellence and innovation possible without the dedication in thanking the 320 scientists at the Institute for 25 years. Bob and significant contribution from and staff at the Institute for their works tirelessly to champion the all of our board members, and in perseverance, imagination and critical need for cardiovascular particular David Craig, our Deputy endurance in helping to fight research in Australia. Chairman and Chairman of the cardiovascular disease. Finance Committee. David spends We are indeed very fortunate While we have put some plans a significant amount of time to have had his strong leadership in place for long-term support supporting the Institute at the Institute for so many years, of the Institute’s work, the need in so many ways. and so, too, are the scores of for philanthropic support of up-and-coming young scientists our cardiovascular researchers who have flourished under has never been greater. Why his mentorship. don’t you join us for the journey – with you on our side the possibilities are endless.

Matthew Grounds CHAIRMAN 10 VICTOR CHANG CARDIAC RESEARCH INSTITUTE

Executive Director’s Report

2018 was a very successful I’d like to thank our Chairman This year saw further progress year for the Institute, both in and board member, Gary Weiss, with the development of the and also Guy Fowler of UBS, for Victor Chang Cardiac Research terms of scientific achievements not only continuing to co-ordinate Institute Innovation Centre – again and financially. My thanks another successful Sohn Hearts generously supported by the NSW to all involved including our and Minds Conference – this time Government – which will feature in Melbourne – but also for setting state-of-the-art equipment so fundraising team, our faculty up the Hearts and Minds Listed NSW scientists can investigate and staff, our Finance and Risk Investment Company, which will cardiovascular research problems Committee, our Board, and provide much-needed financial at a level of sophistication support, not just to our Institute, only possible in a few places the Sohn Hearts and Minds but for research into diabetes in the world. Conference organisers. and children’s diseases. I would like to thank Professor Our annual international Roland Stocker for advancing The highlight of the year was our symposium was hosted by the facility to this point, together success in getting the NSW Government the Heart Research Institute with Professor Sally Dunwoodie to commit $150 million over 10 years to after we joined forces with as Deputy Director, who has now build capacity in cardiovascular research them last year to morph taken over from Roland to lead in the state – this the result of a two- the event into the Sydney the Victor Chang Cardiac Research year campaign involving our Chairman, Cardiovascular Symposium. Institute Innovation Centre into Matthew Grounds, the Chairman of the next decade. the Heart Research Institute (HRI), The Symposium was very well Stephen Hollings, the Scientific Director attended with researchers from In 2018 the Institute published of the HRI, Shaun Jackson, and myself, around the state and featured major papers in leading journals, with great assistance from Professor as our Princesses’ Lecturer, such as Nature, Nature Genetics, Ben Freedman (HRI) and, importantly, Professor Jonathan Cohen, Nature Communications and the from Britt Granath, Victor Chang Cardiac who, together with Professor European Heart Journal (EHJ). Research Institute, who worked tirelessly Helen Hobbs, discovered The EHJ paper from Roland to develop the business plan. the PCSK9 pathway for Stocker’s laboratory reported on cholesterol, which has led the development of a molecular Also, particularly thanks to NSW Premier, to a very powerful treatment imaging tool that discriminates the Hon. Gladys Berijiklian, our Health and for high cholesterol. vulnerable from stable plaque, Medical Research Minister, the Hon. Brad as well as a therapeutic approach Hazzard, and Treasurer, the Hon. Dominic to convert vulnerable to stable Perrottet, for getting behind this initiative plaque. His team is now actively and showing such enormous leadership working to translate these findings to bolster funding for research into the into powerful new approaches number one killer in this country, which to prevent heart attacks. costs the nation $12 billion annually in healthcare costs. ANNUAL REVIEW 2018 11

My thanks to The Heart of the West Charity Ball, hosted by the d Marconi Soccer Club, the Women Against Heart Disease Lunch and the Des Renford Charity Gala Day, which all raised much-needed Several of our people also funds for the Institute’s work. received major recognition of Thank you to all our supporters, their work, including Professor The Hearts our board, the Trustees of the Dunwoodie, who was awarded Mary Aikenhead Ministries, and Minds the Eureka Prize for Scientific St Vincent’s Hospital Australia; Research; Professors Jamie Listed Investment our administrative and scientific Vandenberg and Livia Hool, Company will staff, and the Sisters of Charity, who were elected to the who continue to inspire us and provide much- Fellowship of the International support our work. needed financial Society of Heart Research; support, not just Professor Richard Harvey, But it is our donors, who are who received the NSW Premier’s the lifeblood of the organisation, to our Institute, Prize for Excellence in Medical that I particularly want to but for research Biological Sciences – the second acknowledge, because none of into diabetes year in a row that a member our groundbreaking discoveries of the Institute’s faculty has would be possible without them. and children’s received this award – and diseases. our Chairman was deservedly awarded the Research Champion Award by Research Australia, for his efforts in advocating for medical research. Professor Robert M. Graham AO EXECUTIVE DIRECTOR Our fundraising events continue to help us spread the word that 54,000 Australians will suffer a heart attack every year – that’s one every 10 minutes – and cardiovascular disease will kill one in three of us. Professor Bob Graham, Executive Director d. Preventing Heartbreak: Liza’s Story

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Preventing Heartbreak

Liza’s Story

“I was a fit, healthy mum of two young children when I had my heart attack. There were absolutely no signs and I had no risk factors. It all happened while I was at an open house inspection with my husband. I started to feel a pain in my arm that radiated down from around my shoulder and I was unusually hot and sweaty. I didn’t want to cause a scene because I was surrounded by people I didn’t know, but my husband insisted he call an ambulance. He recognised the signs of a heart attack. Within three minutes of the paramedics arriving, I went into cardiac arrest. My heart stopped beating for over half an hour. The ambulance team performed CPR for 32 minutes, I had seven defibrillation shocks. e I turned blue and my eyes were bulging from all the compressions. I had several broken ribs and I didn’t look in a great way. I was taken to hospital and rushed into emergency where they placed three stents in my heart. I spent six weeks in hospital and also had an ICD fitted before I left. Liza with her daughter, Ella f Liza in hospital after suffering a SCAD heart attack

I now know I suffered from a condition known e. f. as spontaneous coronary artery dissection (SCAD), which is when an inner layer of one of the blood vessels in the heart tears. I just presumed it wouldn’t happen to me and I always imagined that heart LIZA problems were for men over 60 who carried a little bit of weight. I would never have thought that My husband someone as healthy and as active as I was, could 25% or would suffer such a heart attack. thought that he’d SCAD is responsible be telling my kids It’s terrifying to think what could’ve happened that day. for around 25% of Ever since, I’ve begun to look at the world differently. heart attacks in women that mummy I cherish every day and focus on the important things, under the age of 50 died today. like my kids, my husband and my family.”

Research Update

Professor Bob Graham and his team are leading Australian research into SCAD. They now have more than 230 SCAD survivors, including 10 families with more than one affected member participating in this cutting-edge study. Our researchers are currently looking to identify genetic variations that contribute to the development of this disease. ANNUAL REVIEW 2018 13

Organisational Structure Board Committees

Finance and Risk Member CHAIR David Craig St Vincent’s Health Australia CHAIR Paul Robertson AO Media and Communications CHAIR Affiliation Jill Margo AM UNSW Sydney Board of Directors Western Sydney CHAIRMAN CHAIR Matthew Grounds Louise Di Francesco DEPUTY CHAIRMAN David Craig

Scientific Advisory Board EXECUTIVE DIRECTOR Professor Robert Graham AO DEPUTY DIRECTORS Professor Richard Harvey AM Professor Jamie Vandenberg Research Divisions

Cardiac Physiology and Transplantation HEAD CHIEF OPERATING OFFICER Professor Peter Macdonald AM Janina Jancu Developmental and Administration and Core Facilities Stem Cell Biology Victor Chang Cardiac • Essential Services HEAD Research Institute Professor Richard Harvey AM • Finance Innovation Centre • Governance and Policy Molecular Cardiology • Human Resources and Biophysics DIRECTOR Professor Sally Dunwoodie • Information Technology HEAD Professor Robert Graham AO CENTRE MANAGER Milad Melhem Molecular, Structural and Computational Biology HEAD DIRECTOR OF FUND DEVELOPMENT Dr Joshua Ho Ariane Gallop Vascular Biology Fund Development HEAD • Bequests Professor Roland Stocker • Corporate Partnerships • Direct Marketing • Media and Communications • Philanthropy 14 VICTOR CHANG CARDIAC RESEARCH INSTITUTE

Robert M Graham AO Board of EXECUTIVE DIRECTOR “Regrettably, almost Directors everyone has been touched by someone who Matthew Grounds has died of heart disease. CHAIRMAN Despite great progress, “Heart disease is the heart disease remains leading cause of death amongst our leading for both men and killers. We still have women in Australia, much work to do, and with 1 in 5 Australians we need your help.” currently suffering from Peter K Allen some form of heart “The Institute’s medical disease. Our researchers research breakthroughs at the Institute are at save lives. This is an the global forefront of extraordinary outcome, making new discoveries yet given the prevalence that help the significant of cardiovascular disease populations around the globally, the Institute’s world who suffer from world-class research and cardiovascular disease.” mission to promote well- Angelos Frangopoulos AM being is more important “It’s impossible not to than ever.” be impressed by the depth of talent that makes up the Institute’s researchers. Their scientific work is truly world class, and would make Victor Chang very proud of his legacy.” David Craig DEPUTY CHAIRMAN

“We have assembled Terry Campbell AM a world-class team of “The great thing about scientists and doctors independent medical to address Australia’s research facilities such number one killer – as the Victor Chang heart disease.” Cardiac Research Institute is that they attract top research Louise Di Francesco talent because, unlike The successful operations of the “The vital work done universities, they are by the Victor Chang Victor Chang Cardiac Research Institute dedicated entirely Cardiac Research to research at the are heavily reliant on the dedication, Institute scientists, who highest levels.” commitment and vision provided year after year strive to change the medical by our Board of Directors, led by landscape with exciting Mr Matthew Grounds. new discoveries, make a difference not just nationally but globally.” ANNUAL REVIEW 2018 15

Jill Margo AM “In extending the boundaries of knowledge about cardiovascular disease, this Institute John Kean OAM does not only save lives, it “One of my heroes, continues to provide solid Neil Armstrong, blocks of research upon Jennifer Doubell described research as which other scientists creating new knowledge. “The Victor Chang can safely build.” In the case of the Victor Cardiac Research Chang Cardiac Research Institute is host to some Institute, using this of the world’s brightest knowledge is helping minds in cardiac research. solve heart disease.” We’re fortunate in Australia to have such a powerhouse focussed on finding better ways of preventing, detecting and treating Annabel Spring cardiovascular disease, addressing one of the “Heart disease is the greatest burdens in leading cause of death our community.” for all Australians. Shangjin (Jin) Lin Already the research results of the Institute “The heart is where life are helping prevent starts. The work that the birth defects, inherited Victor Chang Cardiac heart diseases and Research Institute does heart attacks.” is world class and critical in helping to mitigate one of Australia’s biggest killers – heart disease.” Dr Gary Weiss “Cardiovascular disease is a major cause of death in Australia, and one of our largest health problems. Our institute Leslie Field AM provides first-class medical research with “The Institute brings groundbreaking results. together the best Hamish Douglass From this research, minds in cardiovascular we also strive to give research and the hands- “My father was incredibly on clinical care of real lucky to have received a all Australians the tools to maintain good heart patients. The research heart transplant in 1990 teams are passionate at St Vincent’s hospital, health and thus prevent cardiovascular disease.” in their pursuit for which extended his life a better understanding by 16 years. My family of the complex causes have experienced of cardiac disease.” first-hand the benefits of breakthrough cardiac research.” 16 VICTOR CHANG CARDIAC RESEARCH INSTITUTE

The Power of Discovery

Rewriting the textbooks on heart formation

DEVELOPMENTAL AND STEM CELL BIOLOGY LABORATORY

Professor Richard Harvey and his team have shed a new light on heart defects in babies.

The findings, published in the prestigious journal Nature, have generated new understanding of how the chambers in the heart form and, importantly, how certain structural heart PROFESSOR HARVEY defects can occur in babies. Even before most women know they are pregnant, This discovery their baby’s heart is already beating in the womb. could provide By this stage, the foetus is approximately 24 days insights into how old and its heart is required for the development h of all the other organs in the body. This means the we might coax correct formation of the heart in the earliest stages the human heart is essential for a healthy baby. to regenerate, Using a mouse model, the team led by Professor which is the holy PROFESSOR STOCKER Richard Harvey and senior scientist Dr Gonzalo grail for heart del Monte Nieto, provided fresh insights into fetal heart development, and in particular chamber growth. researchers and Aside from leading Key to this advance is understanding the role and cardiologists alike. a healthy lifestyle, behaviour of the heart’s various tissue layers. this ‘early warning This discovery centres around three innovations: system’ could be 1. Professor Harvey’s team have shown exactly our best defence how the heart chambers grow in a fetus. against heart 2. Scientists have now shown that the endocardium attacks, many of (cells that line the foetal heart tube) does some exciting gymnastics, which are vital for correct which may be fatal. heart formation. Identifying in whom 3. The research has revealed that the chambers and when heart of the heart begin to form at a much earlier stage attacks will occur than previously believed. remains a holy grail “This new knowledge is vital for understanding of clinical cardiology heart defects in babies and, in the future, for how and personalised we might approach the design of new treatments,” says Professor Harvey. medicine. g ANNUAL REVIEW 2018 17

Harnessing the power of DNA

INHERITED HEART DISEASES LABORATORY

A better diagnostic test could potentially support World first heart attack families affected by cardiomyopathy by helping pinpoint those at risk at the earliest possible stage. breakthrough In the largest patient study of its kind, an investigation VASCULAR BIOLOGY LABORATORY has put whole genome sequencing to the test, measuring its effectiveness as a first-line clinical diagnostic tool for dilated cardiomyopathy. Research led by Professor Roland Stocker has shown it may be possible to both identify After two decades of heart disease research and three years those at risk of a heart attack and prevent it of genetic analysis, the study found there are clear benefits from happening. of using a whole genome sequencing test to help find the causes of cardiomyopathy. In particular, it is a sensitive and The underlying cause of a heart attack more comprehensive test than is currently used clinically, is a build‑up of plaque composed of fatty and it provides rich additional information likely to be material and inflammatory cells on the inside valuable in the future. of the heart’s arteries. Some plaques are known Using the whole genome test, which looks at a person’s as ‘unstable’, resulting in the formation of a clot entire DNA sequence, scientists were able to find the that blocks blood flow to the heart, causing genetic causes of more cases of dilated cardiomyopathy a heart attack. than the standard test, which only looks at a restricted Using a highly sophisticated mouse model, set of heart disease genes. So far, though, whole genome Professor Stocker and his team discovered that sequencing has only been integrated into routine patient the activity of an inflammatory enzyme, known care in a select few instances. as myeloperoxidase, is significantly higher The research, conducted by scientists at the Victor Chang in unstable compared to stable plaques. Cardiac Research Institute and the Garvan Institute of The researchers then demonstrated that Medical Research through the National Cardiogenomics an MRI scan, after injection of a chemical Program, looked at the entire genetic make-up of probe, can be used to accurately and selectively 42 patients with dilated cardiomyopathy. This inherited identify the presence of dangerous plaques disease causes the heart to weaken and enlarge, and

can affect up to 1 in 500 Australians. It is also the most Professor Roland Stocker Dr Gonzalo del Monte Nieto and Professor Richard Harvey in coronary arteries. Administered into the Professor Diane Fatkin blood stream, the chemical probe highlights common reason for heart transplantation. g. h. i. the dangerous plaques, making it easily visible on an MRI scan. The team then investigated whether elevated PROFESSOR FATKIN enzyme activity causes plaque destabilisation. The results were really exciting. When researchers It’s hugely satisfying administered a drug that inhibits myeloperoxidase that we can now say to activity, they discovered it stabilised the plaque by making its lining sturdier and less prone clinicians: yes, you should to rupture. absolutely consider whole- The next step is to adjust the chemical MRI genome sequencing as the probe for human use, and then carry out test of choice in families clinical trials to confirm the utility of both the new imaging techniques to identify and treat, at risk of developing high‑risk patients. cardiomyopathy. i The Solution: Seeing really is believing

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The Solution

Seeing really is believing A young scientist is using fundamental knowledge to play with biology and is having fun while doing it Dr Alastair Stewart presenting at the 2018 Sohn Hearts & Minds Conference j. ANNUAL REVIEW 2018 19

Never did Dr Alastair Stewart think a holiday to ‘the land down under’ would see him sharing skills, ideas and experiences with some of the brightest minds in cardiovascular research.

What started out as a summer volunteer role while on a gap year in Australia, has since seen Dr Alastair Stewart reach many milestones, both in and out of the laboratory. However, it’s his transition into the industry that caught him by surprise. “I originally came to Australia to have a gap year, with no intention of practicing science. When I arrived, I cared for flying foxes through a bat conservation program. Colonies of these flying foxes were slowly being wiped out, so at the time we were trying to preserve their habitats.” Growing up in Cambridge, Dr Stewart was no stranger to the world of science. Concepts such as macromolecules and nucleic acids were thrown around at the dinner table from a young age, as both his parents were scientists themselves. And while he ended up following in the family business, it was dedication, curiosity and his desire to imagine the unimaginable that landed him in the field of structural biology.

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The Solution

k

“In 2007 I started my volunteer role here From the very start at the Institute. I was mainly here to gain and at the very heart l skills in the laboratory. I was purifying The human body is an incredibly efficient proteins, making enzymes and learning machine. It only requires around 2,000 about molecular biology. This experience calories a day to function, which is about really made me think about molecules … the same as an old fashioned 100-watt how they come together and what they’re light bulb. The heart uses the majority doing. That’s really what pulled me into of this energy to pump blood throughout this area of study.” our bodies, enabling us to get out of bed every day. Dr Stewart’s determination in the m laboratory saw him appointed to Research When there is a genetic mutation Assistant in Dr Daniela Stock’s Structural or a problem with the production line Biology team. From there, he completed of energy inside our cells, this can lead his PhD, performed a post-doctoral to debilitating diseases such as infant fellowship, before returning to the heart failure. Institute as a Group Leader to start his own laboratory in 2016. Every week, 42 babies are born with a congenital heart defect. As a new father “My team now researches energy production himself, Dr Stewart believes that seeing and how biological energy conversion can really is believing, and by understanding play a role in the development of heart the fundamental mechanisms of how disease. We look deeply into the world molecules work, his research will have inside you, at the little cells which have quite a huge impact on the world. thousands of motors rotating around making all your energy.” Molecular animation created by Dr Drew Barry Alastair at the beach with his daughter, Isabella Dr Alastair Stewart in his laboratory Dr Stewart presenting at the 2018 Sohn Hearts & Minds Conference k. l. m. n. ANNUAL REVIEW 2018 21

A little bit of chemistry We aim to understand how molecules In science, finding answers can work and how we could potentially fix be painfully time consuming and meticulous; finding an them, so hopefully one day we’ll be able answer may lead to another to cure genetic mutations in children. “Without the knowledge question, but research is about of how something works, it’s perseverance, collaboration and almost impossible for us to fix intrigue. It’s these qualities that DR ALASTAIR STEWART it. By understanding molecules, have seen Dr Stewart recognised we have a real ability to make with several prestigious important discoveries and provide industry awards. answers to some of biology’s most unanswered questions. I want But perhaps his most momentous to be able to find better ways achievement at the Victor Chang to detect and treat heart disease Cardiac Research Institute would so when young children ask their be meeting his now wife, Laura, parents why they have a broken and welcoming a beautiful baby heart, they’ll be able to provide girl into the world. As he liked to them with an answer.” put it, the Institute has provided him with a family in more ways And how is he going to find than one. that answer? Well, the clues may lay behind a microscope. And so they say having a child No ordinary microscope, like changes your perspective on life, the ones in school science labs. but for Alastair it’s only made We’re talking imaging molecules him more determined to achieve at an atomic scale. At six foot four his goal and change the course inches tall, Dr Stewart is dwarfed of biology as we know it. by the microscope, which is more than double his size and costs over $6 million. “In order to make discoveries, we need to use one of the world’s most powerful microscopes, Driving our known as a cryo-EM. We’re lucky enough to have Sydney’s first discoveries multi-million-dollar machine as part of the Victor Chang Cardiac n Research Institute Innovation Centre. This really is enabling us to build the future of structural Dr Alastair Stewart’s research has been supported biology and be at the forefront by the National Health and Medical Research Council. of our field.” It also has received a generous contribution from the Baxter Charitable Foundation. This funding is integral in sustaining the ongoing success of the research program at the Victor Chang Cardiac Research Institute. Equipping our scientists with the very best technology is critical in driving discoveries. The Solution: Our ace of hearts

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The Solution

Our ace of hearts Meet the pioneer credited with the most important advance in heart transplantation in three decades ANNUAL REVIEW 2018 23

Professor Peter Macdonald is used to long journeys. He walks long distances for fun – 500 kilometres of hiking trails whilst on holidays – and doesn’t mind travelling 450 kilometres just to go to work some days (more on that later). But it’s his stamina and extraordinary discoveries in the voyage of cardiovascular research for which he is most revered in medical circles around the globe. Professor Macdonald and his team at the Victor Chang Cardiac Research Institute developed a unique preservation solution that, combined with a portable “heart in a box” machine, extends the amount of time a donor heart can spend in transit from four to 14 hours. This means donor hearts can be transported further and so be better matched with a recipient, improving the outcomes for patients. The revolutionary technique also allows donor hearts that have stopped beating to be reactivated, so that at least 20% more transplants can be performed each year in Australia, and around the world. It is described as the most important global advance in heart transplantation since organ transplants began in the early 1980s, but you wouldn’t know it, talking to the humble man with a dry sense of humour, whose “other job” is as a highly respected cardiothoracic specialist at St Vincent’s Hospital, where the Cardiopulmonary Transplant Program is regarded as one of the most successful in the world. “In all of our years, our biggest hindrance has been the limited availability of organ donors. In many respects this breakthrough represents a major inroad to reducing the shortage of donor organs,” Professor Macdonald said, understatedly. A similar character trait, according to those who knew him, to that of Dr Victor Chang, who was one of Professor Macdonald’s early mentors. It was 30 years ago when Professor Macdonald was in his first year as a Cardiology Fellow at St Vincent’s Hospital Sydney that Dr Chang asked him to stay. He packed up his wife and small children from Melbourne and moved to Sydney’s southern beaches, having decided to devote his career to heart failure and transplantation. Professor Peter Macdonald Peter Professor

o. “Beta blockers were just starting to be investigated … there were surgical solutions. It seemed to me there was more you could do for the heart than any other organ o or system in the body.” 24 VICTOR CHANG CARDIAC RESEARCH INSTITUTE

The Solution

Race against the clock The first time he was sent to retrieve a heart for transplantation was “exhilarating and confronting at the same time,” he recalled. “I flew there and back with the heart and watched it all being sewn in – there’s nothing that prepares you for that experience.” “There were green lights all along South Dowling Street for the police escort from St Vincent’s Hospital to the airport, which we did in just seven minutes. “Later I remember Victor casually telling me p their record was four minutes … he was witty and funny, and he had charisma.”

Professor Macdonald remembered once For more Australians assisting Dr Chang in the early days of For patients with heart failure who are lung transplantation. The two lungs from not eligible for transplantation, Professor one donor were being transplanted into Macdonald and his colleague, Professor different recipients, so two operating Chris Hayward, have played a critical theatres ran simultaneously. role in the team that has developed “There weren’t as many surgical assistants a highly successful program implanting in those days, so they roped me in to mechanical devices, such as defibrillators helping – mainly holding a retractor – and pacemakers. but I remember that the atmosphere in Professor Macdonald’s expertise managing the theatre was very relaxed, with Victor critically ill patients helps to translate making it all look very straight forward, laboratory findings into clinical practice, although it was only his first or second 100 driven purely by wanting to extend life- lung transplantation.” At any one time saving treatments to more Australians. at least 100 people He said being a cardiothoracic specialist, are on the waiting To all Australians, that is, including our and a scientific researcher, was the perfect list for a heart indigenous community. partnership of jobs. transplant Which is why Professor Macdonald travels “You see challenges in the hospital, and 450 kilometres each way, one day every you come in here to the Institute to try six weeks or so, in a 1960s Chifton 8-seater to find solutions to those problems.” propeller plane to work at the Condobolin Professor Macdonald said his team in Aboriginal Medical Centre in outback the Cardiac Transplantation Laboratory New South Wales. want to improve donor heart preservation techniques even further, and develop better methods to manage organ donations. Professor Macdonald seeing patients in Condobolin Condobolin in patients seeing Macdonald Professor Professor Macdonald and his team in an operating theatre Peter Macdonald and colleagues in Condobolin Condobolin in colleagues and Macdonald Peter

p. q. r. ANNUAL REVIEW 2018 25

I remember that the atmosphere in the theatre was very relaxed, with Victor making it all look very straight forward, although it was only his first or second He cited the gap in life expectancy between Aborigines and non-indigenous Australians, lung transplantation. plus the imbalance of cardiovascular disease

among the indigenous population, as reasons PROFESSOR PETER MACDONALD for wanting to “give something back”. So he’s been going back to Condobolin for 12 years. Professor Macdonald has been heard before to say: “I won’t solve the problem, but at least it’s something,” which would be why he is described by his peers as “very much a noble, humble guy”. “There are not too many people who can say their research has had such as major impact on the world,” said Professor Graham, Executive Director of the Victor Chang Cardiac Research Institute. Professor Macdonald, who has been awarded a Queen’s Birthday Honour for q services to cardiovascular research and heart transplantation, has published more than 300 research papers. Driving our His three adult sons have left home, but he gets to see them once or twice discoveries a week; he body surfs at Maroubra Beach, and he really enjoys hiking with his wife. The best training for that, he said, is playing golf once a week. The groundbreaking work by Professor The hardest part of any of his jobs, Peter Macdonald and his team is funded Professor Macdonald said, “is referring by the National Health and Medical a patient for a transplant and finding Research Council and the St Vincent’s r out they are not suitable, then having to Clinic grants program. say ‘sorry, we can’t help you’. They place a lot of trust in you,” he said, solemn Making a philanthropic investment into for just a moment. “And so have very this new era in heart transplantation high expectations.” A fairly well-placed means our scientists can continue their presumption, wouldn’t you agree? search for ways to even further extend the time that donor hearts can spend in transit before transplantation. The scarcity of suitable donor organs makes this a life-changing difference. The greater the timeframe, the better donor hearts can be matched to recipients, meaning more heart transplants being performed and better patient recovery outcomes. The Solution: Sequence of success

26 VICTOR CHANG CARDIAC RESEARCH INSTITUTE

The Solution

Sequence of success

How one team of scientists uses mathematics and computing to accelerate research

Doctor Eleni Giannoulatou’s work underpins some of the greatest discoveries in cardiovascular research in the past decade in Australia. That’s because her Computational Genomics Laboratory at the Victor Chang Cardiac Research Institute continues to develop next-generation techniques to speed up the analysis of massive datasets – information taken from patient DNA – to identify mutations that cause different types of heart disease. Despite the complexity of whole genome sequencing, Dr Giannoulatou explains it simply: “We develop computational methods and mathematical models to analyse large volumes of data from the DNA of patients more efficiently and quickly than we’ve ever been able to before.” Indeed, without Dr Giannoulatou’s team, her colleague Professor Sally Dunwoodie might not yet have discovered the potential of vitamin B3 to treat a molecular deficiency causing miscarriages and complex birth defects. The breakthrough is akin to the revolutionary finding last century that confirmed folic acid supplements could prevent the neural tube defect spina bifida in babies. As a result, consumption of folic acid has been adopted by expectant mothers worldwide, and the addition of folate to our food supply has led to a 70% decrease in the number of babies born with neural tube defects. “To be part of such a discovery makes me feel really proud,” Dr Giannoulatou said. Dr Eleni Giannoulatou Giannoulatou Eleni Dr s. ANNUAL REVIEW 2018 27

s 28 VICTOR CHANG CARDIAC RESEARCH INSTITUTE

The Solution

“We live in an era of unprecedented Power of genetics amounts of biological and genetic data. Dr Giannoulatou was 22 years old, with Using computational methods, we can a Masters of Computer Engineering and now derive insight from these datasets Informatics, when she left Greece bound to improve medical decision making. for the UK, where she earned her Master of Philosophy in Computational Biology “The best part is analysing genetic data at Cambridge University in 2005, and her that hasn’t been seen before; looking Doctor of Philosophy in Bioinformatics to see if the data can explain our genetic at Oxford University in 2011. questions, especially when you get a brand‑new dataset. She then came to Sydney to join the Victor Chang Cardiac Research Institute in 2013 as “That’s what I was doing this morning, 4/wk a member of the Bioinformatics and Systems I still wanted to look myself – it still Congenital heart Medicine Laboratory, and only two years excites me,” she added, with a level disease kills four later started an independent research group. of enthusiasm more commonly seen babies every week Just a year after that, she became a faculty in a young university student. in Australia member. She’s still only 38 years old. “There is a lot of support in this Institute as it recognises the importance of bioinformatics and bioinformatics research and the power of genetics in solving important clinical problems,” Dr Giannoulatou said. Driving our “We all carry numerous genetic variations, discoveries but finding the rare ones that cause disease is hard, unless you have enough data or statistical evidence.

Dr Eleni Giannoulatou is fortunate to receive support from the NSW Office for Health and Medical Research, the Heart Foundation and the National Health and Medical Research Council. By making a philanthropic investment towards improving the diagnosis of genetic diseases using computational methods, you will assist her team to:

• Develop new analytical approaches to improve our ability to detect mutations that cause heart defects in babies

• Analyse large DNA datasets to identify genetic mutations that contribute to spontaneous coronary artery dissection (SCAD) t

• Use genetic information to predict the risk of developing dilated cardiomyopathy

ANNUAL REVIEW 2018 29

“I can’t speak highly enough of Eleni,” said Professor Graham. “She has a level of thinking and analysis that is rare, and is always open to new ideas and to looking at things in a new way.” But while her quest at work is to find the genetic causes of cardiovascular diseases, at home she and physicist husband Matt are sometimes hard-pressed to u just find their two-year-old son Georgios, whose favourite game is hide-and-seek. They take Georgios to Greece once a year, and her family The Institute recognises the importance visits annually so that Yiayia of bioinformatics research and the power of and Pappou can enjoy their grandson’s play time too. genetics in solving important clinical problems. Dr Giannoulatou said the Institute had provided her with, among

Dr Giannoulatou and her bioinformatics team of researchers Dr Giannoulatou in her laboratory

t. u. DR ELENI GIANNOULATOU many other things, outstanding role models. “I feel so fortunate to have all of these collaborations. I think “We simply have to develop more Precision medicine they have all been very successful sophisticated methods to find mutations, Considerable excitement, scientists – I wish I could become and to look in the not-so-obvious places.” she explained, surrounds the like them one day. genomic revolution in healthcare, A demure scientist, Dr Giannoulatou and which promises treatments on “I’d like to be internationally her team work collaboratively with many the basis of a person’s unique recognised for my work too, but laboratories, including that of founding DNA sequence: their genome it is the genetic questions and the Executive Director Professor Bob Graham, – so called personalised or love of finding the answers that which is trying to elucidate the genetic precision medicine – in contrast motivates me. basis of spontaneous coronary artery to the empirical treatments dissection (SCAD): a disorder that affects “I would encourage everyone to available today. and, unfortunately, not infrequently kills consider studying STEM subjects, otherwise healthy young women in their So it’s no surprise that her team not only because of the difference 40s and 50s. has this year more than doubled you can make in people’s lives, in size. but also all the different places She also works with Deputy Director it can take you.” Professor Richard Harvey on hypoplastic You wouldn’t need to spend left heart syndrome, a very severe type of longer than a coffee break with And there is no doubt that this congenital heart disease, and with Professor Dr Giannoulatou to know she’d be young scientist is most definitely Dianne Fatkin on dilated cardiomyopathy – more than just a little embarrassed going places. one of the most common forms of heart hearing herself described as an disease causing severe heart failure “extremely intelligent young necessitating a heart transplant. superstar” by her peers. 30 VICTOR CHANG CARDIAC RESEARCH INSTITUTE

Research At the Victor Chang Cardiac Research Institute, Divisions we integrate innovative transplantation techniques, advanced stem cell research, bioengineering, and complex molecular and genetic analysis – to discover better ways to diagnose, treat and ultimately prevent the onset of heart disease.

3 1

Cardiac Physiology Molecular Cardiology and Transplantation and Biophysics

Macdonald Laboratory Graham Laboratory • Heart transplantation • Cardiac regeneration • Donor heart preservation • Heart failure • New heart failure treatments • Hypertension Hayward Laboratory 2 Vandenberg Laboratory • Heart failure • Arrhythmias • Left ventricular mechanical • Electrical activity in the heart support devices Developmental Hill Laboratory Feneley Laboratory and Stem Cell Biology • Drug-induced arrhythmias • Cardiomyopathy • Computational cardiology • Heart attack Harvey Laboratory Fatkin Laboratory • Ischemic heart disease • Heart development • Dilated cardiomyopathy Keogh Laboratory • Congenital heart disease • Atrial fibrillation • Pulmonary hypertension • Heart stem cells & regeneration • Inherited heart disease • Heart failure Dunwoodie Laboratory Martinac Laboratory • Immunosuppression • Congenital heart disease • Ion channels in the heart Muller Laboratory • Embryonic development • Mechanical forces • Structural heart disease • Birth defects Hool Laboratory • Valvular heart problems Kikuchi Laboratory • Cardiomyopathy Jabbour Laboratory • Heart muscle regeneration • Heart failure associated • Heart transplant rejection • Heart failure with muscular dystrophy • Magnetic Resonance Imaging Winlaw Laboratory Smith Laboratory Dhital Laboratory • Congenital heart disease • Hypertension • Heart transplantation • Genetic analysis • Pharmacology ANNUAL REVIEW 2018 31

Clinical Faculty Honorary Faculty

A/Prof Cameron Holloway Prof Oliver Freidrich A/Prof Jane McCrohon Prof Matthias Hentze Dr James Otton Prof Ahsan Husain A/Prof Jacob Sevastos Dr Lawrence Lee Dr Phillip Spratt Dr Ming Li A/Prof Rajesh Subbiah Prof David Martin Prof Andras Nagy Prof Soren-Peter Olsen Dr W. Andrew Owens Prof Thomas Preiss

4

6 Molecular, Structural and Computational Biology

Ho Laboratory Victor Chang • Bioinformatics • Mass analysis of human Cardiac Research Institute genomic data Innovation Centre 5 Giannoulatou Laboratory • Bioinformatics Professor Sally Dunwoodie • Cardio genomics Director • DNA analysis Vascular Milad Melhem Manager Stewart Laboratory Biology • Protein structure A/Professor Mark Hodson • Cryo-electron microscopy Stocker Laboratory Metabolomics Laboratory Christie Laboratory • Atherosclerosis Dr Ashish Mehta • Protein biochemistry • Heart attack iPSC and Phenotyping • Protein function • Stroke Research Laboratory Victor Chang Cardiac Research Institute Innovation Centre

32 VICTOR CHANG CARDIAC RESEARCH INSTITUTE

Proudly supported by the NSW Investing in Government, the Victor Chang Cardiac Research Institute Innovation Centre the future of will place NSW at the forefront of heart research cardiovascular research in Australia, facilitating a new era of collaboration The Victor Chang Cardiac between researchers across the state Research Institute Innovation and the Asia Pacific. Centre will herald a medical The Innovation Centre will allow researchers to tackle Australia’s deadliest killer through research revolution, helping access to state‑of‑the-art equipment and the 4.2 million babies and adults cutting‑edge technologies. around Australia affected by This year, the Innovation Centre’s heart disease. Cyro‑electron Microscopy Facility at UNSW Sydney was officially opened by Nobel Laureate Professor Joachim Frank. This facility is now home to one of the world’s most powerful microscopes for imaging frozen, atomic-sized molecules in 3D, giving scientists unprecedented insights into cardiovascular disease.  Dr Gavin Chapman working in the Victor Chang Cardiac Research Institute Innovation Centre

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Building works and equipment procurement across the four facilities within the Victor Chang Cardiac Research Institute have now been completed and received certification. The Advanced Cardiac Imaging Centre at St Vincent’s Hospital Sydney will be launched in 2019. Altogether, the Victor Chang Cardiac Research Institute Innovation Centre will push the boundaries of knowledge by transforming the landscape of cardiovascular research in NSW.

Proudly funded by Preventing Heartbreak: Fred’s Story

34 VICTOR CHANG CARDIAC RESEARCH INSTITUTE

Preventing Heartbreak

Fred’s Story

“I had a midlife crisis at 34. That was the year my beautiful dad died after a long struggle with heart disease. He was 68. My dad was a quietly intelligent man who had a smile that could light up a room, no matter how much he was hurting on the inside. Dad had a long list of heart problems that first emerged around the year 2000. w He had an enlarged heart. Later there was surgery to insert stents. I still recall the surgeon reading him the riot act because there was so much calcification in his heart, he couldn’t perform one part of the operation. Dad casually revealed that he wasn’t surprised, because his parents and grandparents also had cardiovascular issues. I was stunned. That meant that there were three generations of heart disease in front of me. I naively thought the worst aspect of heart disease was the prospect of having a fatal heart attack. I had no idea how debilitating it could be. I watched my dad, who used x to do the crossword in the newspaper every day, struggle to pick up a pen. And after a quadruple bypass my Mum called

me. My Dad, her best friend, was beyond NICOLE, FRED’S DAUGHTER exhausted. ‘He won’t get better. He has chronic heart failure. That’s what I’m trying to tell you Nicky.’ I’m grateful for the work the Victor A few months later Dad had a fall. And his sick heart couldn’t sustain him. Chang Cardiac Research Institute I held his hand and resolved that my 1/3 daughter wouldn’t ever be in the same is doing to save One in three position thinking ‘It didn’t have to be lives. And I’m Australians die this way.’ prematurely of hopeful that one cardiovascular I think the greatest tribute I can offer is day, it won’t be disease to live the life Dad can’t and look after my heart. My doctor says you can’t change necessary. your genetics, but you can minimise the

risk factors.” Nicole and her dad, Fred, on her wedding day Fred in hospital looking at photos of his grandchildren

w. x. ANNUAL REVIEW 2018 35

Statement of Income and Expenditure

2018 2017 For the year ended 31 December $ $

Income Research grants 13,797,156 12,774,886 Donations and fundraising 8,722,7251 2,849,366 Investment and other income 2,141,432 2,090,217 Total income 24,661,313 17,714,469

Expenses Research expenses 15,119,422 14,680,685 Administration expenses 6,264,770 5,886,458 Fundraising expenses 1,637,115 1,411,149 Total expenses 23,021,307 21,978,292

Operating surplus/(deficit) 1,640,006 (4,263,823)

Non operating income/(expenses) Innovation Centre grant 3,589,482 – Depreciation on Innovation Centre equipment (1,051,798) – Unrealised (loss)/gain on investment revaluation to market (1,097,340) 987,70 5

Net surplus/(deficit) for the year 3,080,350 (3,276,118)

1. Donations and fundraising activities include an incremental investment of approximately $3 million made in 2017 in developing and implementing strategically focused fundraising activities of Regular Giving and Direct Marketing Appeals. Comparative figures have been adjusted to conform with changes in presentation for the current year. The above is an extract from the 2018 audited Financial Statements. The extract does not include the information normally included in the financial statement. Accordingly, this extract is to be read in conjunction with the audited Financial Statements for the year ended 31 December 2018. 36 VICTOR CHANG CARDIAC RESEARCH INSTITUTE

Health Check Booth

Keeping the hearts of Australia healthy The Victor Chang Cardiac Research Institute 1/3 Health Check Booth travels right across the country, One in three testing Australians for the key modifiable risk factor participants y of heart disease. have one or more modifiable In 2018, our Health Check Booth provided risk factors of heart health checks to more than 10,000 people heart disease – from community groups to corporate employees – helping Australians to better understand their blood pressure, total cholesterol and blood sugar.

Our mobile heart health checks are carried out DIANE, PARTICIPANT by qualified nurses in less than ten minutes using fast, reliable and non-invasive testing equipment. Participants walk away with their results and advice The Health Check on how to lead healthier lives to minimise their Booth is an excellent chances of developing heart disease. service and I come The Victor Chang Cardiac Research Institute every year. The staff Health Check Booth is generously supported are fantastic, and by HCF and IMB Community Foundation. it is so convenient. For all enquiries or to book the Health Check Booth, It’s a great reminder please contact Jayne Baric on (02) 9295 8760 or [email protected] to keep looking after myself. Thanks for the great service. Nurses Sanya, Jayne, Chris and John with Panthers great, Royce Simmons A participant having their blood pressure taken

y. z. 2018 Results

10,035 77 6 Australians tested regions around Australia states

32% 90% 38% had high cholesterol did not know their were advised blood sugar level to visit their GP ANNUAL REVIEW 2018 37

z 38 VICTOR CHANG CARDIAC RESEARCH INSTITUTE

SOHN AUSTRALIA HEARTS & MINDS INVESTMENT LEADERS CONFERENCE

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Sohn Hearts & Minds Investment Leaders Conference

The Sohn Hearts & Minds With record attendance of 1,000 people, a stellar line-up Investment Leaders Conference of local and global fund managers shared their top investment tip with the aim of generating exceptional returns for medical 2018 was held in Melbourne research in Australia. The line-up of international experts for the first time at Hamer Hall. included Babak Poushanchi, Cota Capital (USA) and Beeneet The world-class event brought Kothari, Tekne Capital Management (USA); local gurus included Emma Goodsell, Airlie Funds Management and together the most illustrious Jun Bei Liu, Tribeca Investments. members of Australia’s fund We welcomed the support of the Federal Treasurer management community to hear The Hon. Josh Frydenberg, MP, and were delighted by from the brightest investment guest appearances from presenter and comedian Andrew minds from around the globe. Denton and CEO of the AFL, Gillon McLachlan. The conference raised over $3 million for its beneficiaries, which included the Victor Chang Cardiac Research Institute, the Black Dog Institute, MS Research Australia, the Juvenile Diabetes Research Foundation and Murdoch Children’s Research Institute. Integral to the success of the conference is the ongoing and generous support of our major partners, the Commonwealth Bank and the Paul Ramsay Foundation for which we are deeply grateful. ANNUAL REVIEW 2018 39

FRIDAY 16 NOVEMBER 2018 HAMER HALL, ARTS CENTRE MELBOURNE MELBOURNE, AUSTRALIA

C D Dr Alastair Stewart, Victor Chang Cardiac Research Institute Jun Bei Liu, Tribeca Investments Australian businessman, Solomon Lew TV personality, Andrew Denton and CEO of the AFL, Gillion McLachlan A. B. C. D.

Hearts & Minds Investment Limited Sohn Hearts & Minds

A new investment company Hearts & Minds Investment Limited (HM1) was established following the Sohn Hearts & Minds Investment Leaders Conferences. This innovative fundraising model aims to further boost funding for medical $10m+ research institutes in Australia and is aimed at investors seeking raised for medical research exposure to a high conviction portfolio of global equities. HM1 will forego any investment fees and instead make donations to designated medical research institutes. The HM1 Board and Investment Committee have waived the right to be a paid director. The brokers for the offer waived management fees. 75 55 HM1 recognises that investment in medical research is speakers partnerships critical and that medical research provides strong returns that benefit the health of the community. For every dollar invested in medical research, it is estimated that an average of $2.17 in health benefits is returned. HM1 will support the development of new medicine and 2,200 drive a new generation of medical research in Australia. conference attendees 40 VICTOR CHANG CARDIAC RESEARCH INSTITUTE

Achievements 3 and Awards

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Scientific Accolades PhD’s Awarded

Professor Richard Harvey 1 Professor Jamie Vandenberg 4 Dr Yury Nikolaev Winner Fellow Mechanobiology NSW Premier’s Prize for Excellence Fellowship of the International Dr Matthias Duebbert in Medical Biological Sciences Society of Heart Research Epigenetics Professor Sally Dunwoodie 2 Professor Livia Hool 5 Dr Hananeh Fonoudi Winner Fellow Developmental and Eureka Prize for Scientific Research Fellowship of the International Stem Cell Biology Society of Heart Research Winner Dr James Coleman President’s Medal, Australia and Dr Stewart Heitmann 6 Molecular Pharmacology New Zealand Society for Cell and Winner Developmental Biology Dynamical Systems Software Prize, Dr Dhanushi Abeygunawardena Society of Industrial and Applied Developmental and Mr Matthew Grounds 3 Mathematics Stem Cell Biology Winner Research Champion Award, Research Australia Health & Medial Research Awards ANNUAL REVIEW 2018 41

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10 11 15

12 13 16

Victor Chang Cardiac Research Institute Awards Victor Chang Community Awards

Dr Xin Wang Dr Gonzalo del Monte 8 Mr Guy Fowler 10 Victor Chang Award for Excellence 14 Bioinformatics and Postdoctoral Fellow Supporter in Cardiovascular Journalism Systems Medicine Paul Korner Seminar Series Award Life Governor Award Dr Norman Swan and James Bullen, ABC Radio National Dr Louis Wang 7 Mr Sean So Mr David Craig 11 Inherited Heart Disease PhD Student Deputy Chairman Victor Chang Heart of Gold Awards 15 Paul Korner Student Award Life Member Award 37 Australians honoured for Dr Chung-Yao Yu helping save the life of someone Cardiac Transplantation Dr Anita Ayer 9 Sr Anthea Groves 12 having a heart attack or cardiac arrest Postdoctoral Fellow RSC, OAM Dr Tomasz Szczesnik Paul Korner People’s Former Board Member Victor Chang School Science Awards 16 Bioinformatics and Choice Award Life Member Award Over 200 Year 11 students Systems Medicine across NSW commended for Ms Kate Thomas Ms Louise 13 Dr Navind Jayasooriah excellence in science Cloud 9 Cafe Di Francesco Epigenetics Executive Director’s Award Board Member Honorary Award 42 VICTOR CHANG CARDIAC RESEARCH INSTITUTE

Fundraising Events

Women get Cuban inspired Tour-de- Charity steer breaks to the heart night by the bay Adelaide an-udder record of the matter

MARCH 2018 APRIL 2018 APRIL 2018 AUGUST 2018

More than 150 guests gathered Four teams of dedicated Livestock heavyweights Schute Putting a spotlight on the on the waterfront of Watsons corporate cyclists from Bell Badgery Lumby celebrated importance of women’s Bay Beach for the annual Bay across NSW completed a twenty-year milestone at heart health, the annual Soiree. Hosted in partnership an extremely tough the 2018 Sydney Royal Easter Women Against Heart with Watsons Bay Boutique Hotel, 1,000 km tour across Show’s Charity Steer Auction. Disease Lunch was guests were transported to the the beautiful Adelaide 600 kg prime steer, Dub the a huge success. Guests Caribbean to enjoy a bespoke Hills, to raise money for limousin was auctioned off were left inspired after Cuban-inspired menu. After babies born with heart for a record-breaking $66,000, hearing from double a night of fedoras, mojitos defects. Overcoming with all proceeds donated to transplant recipient and and la musica Cubana, guests tough terrain, extreme cardiovascular research. Raised, Ironman contestant, Kate raised over $30,000 to support weather conditions, fed and nurtured by the students Phillips, and cardiologist, a young researcher’s quest to flat tyres and multiple at Murrumburrah High School, Dr Fiona Foo. Established find cures for heart disease. leg cramps, The Chain Dub was bid on and won by to honour the memory A big thanks must go to our Reaction Challenge the generous Paul Ferry for of Monica O’Loughlin, MC Todd McKenney, the Young Foundation raised the tenth year in a row. the event raised $70,000 Appeals Committee, Marcus $91,000 for congenital for our scientists. A big Chang, Fraser Short, the team heart disease research. thanks must go to our at Watsons Bay Boutique Hotel MC Natalie Barr and and all of our sponsors. all sponsors.  Students from Murrumburrah High School at the Charity Steer Auction Guests enjoying the Bay Soiree Riders participating in the Chain Reaction Challenge

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Hole‑in‑one Putting heart Forecast of fun honours into the West at charity gala day dad’s legacy

SEPTEMBER 2018 NOVEMBER 2018 NOVEMBER 2018

Over 350 people put on For the eighteenth consecutive The fifth Glen Carling Golf Day their finest frocks to attend the year, the Des Renford Charity was an extremely successful day Heart of the West Ball at Club Gala Day put on a fun filled event out on the green. Dedicated to Marconi. With a line-up of for the whole family. Thousands the memory of Glen Carling and extraordinary talent, delicious of people enjoyed splashing his passion for golf, the event has food and important messages, around the pool, sausage sizzles, raised a cumulative total of more the night was a huge success. petting zoos, face painting and than $126,000 for the Victor The Ball raised more than $80,000 much more. The day raised over Chang Cardiac Research Institute. for Victor Chang Cardiac Research $42,000 to support research Remembered as an incredible Institute scientists. A big thank into heart disease. This event man by his family and friends, you must go to The Committee wouldn’t be possible without the annual event keeps Glen’s of Western Sydney including the generous support from legacy alive. The event was Louise Di Francesco, Vince Foti, Randwick City Council, Michael established by Norm Atkinson, Tony Zappia, Danny Rezek and Vanessa Renford, all of our Gemma Carling and the and Deloitte, Craig Wellman, event sponsors and the wonderful extended Carling Family. Club Marconi and heart team of volunteers. transplant survivor, Melissa Petro‑Hargrave.  DrFiona Foo, Natalie Barrand heart transplant survivor, Kate Philips at the Women Against Heart Disease Lunch Jerry, Robert and John at the Glen Carling Golf Day Children enjoying the Des Renford Charity Gala Day Guests enjoying the Heart of the West Ball H. I. J. K.

H I J K 44 VICTOR CHANG CARDIAC RESEARCH INSTITUTE

Supporters and Acknowledgments

Our life-saving research would not be possible without the generous commitment of our valued supporters.

These categories represent cumulative Discoverers philanthropic support received over ($100,000 – $499,999) the past 10 years. Bing Lee Electronics Chairman’s Council Citigroup Club Marconi ($1 million+) Commonwealth Bank Chain Reaction Challenge Foundation Consolidated Press Holdings Ltd Crown Resorts Foundation David Craig HCF Richard Elmslie NSW Government Ernst & Young The Lowy Foundation Paul Ferry Glen Carling Golf Day Goldenland Australia Property Pty Ltd Director’s Lab Gray Family Foundation ($500,000 – $999,999) Matthew Grounds High Pass Holdings Pty Ltd ANZ Banking Group Ltd Jessica Hore Aqualand RW Ingham AO Balmoral Pastoral Pty Ltd Mark Johnson De Groot Industries Pty Limited LFG Barbara Ell OAM MCK Family Pty Ltd Inghams Enterprises Pty Limited Mineral Resources Limited The Freedman Foundation PAF Mandalay Ervin Vidor AM Priceline Pty Ltd Diana Ritchie Tim Roberts Seven Group Holdings Simon Lee Foundation The Helping Hand Group The Key Foundation The Lady Fairfax Charitable Trust The Profield Foundation UBS Foundation Westfield Holdings Limited ANNUAL REVIEW 2018 45

Magellan Asset Management Limited Partners Angelo Maggiotto Supporters ($25,000 – $99,999) Susan Maple-Brown AM ($5,000 – $24,999) Geoffrey Marshall Alceon Group Pty Ltd ABC Tissue Products Master Management Pty Limited Appliances Online Accenture McDonald Jones Homes Foundation Pty Limited Ariadne Australia Limited Lenore Adamson Mark Mezrani Australian News Channel Gretel Ainsworth Wayne Morris AW Edwards Pty Ltd Allard Partners Mark Nelson G Belgiorno-Nettis AM Trevor Allen Patricia New Capital Investment Partners Alvaro Brothers Pty Ltd Oakville Produce Group Carla Zampatti Foundation American Express Australia Ltd P & M Quality Smallgoods Pty Ltd William Chalk AMP CAPITAL Paceline Inc Evelyn Chan AMP Services Limited PwC Australia Ann L Chang Angles Family Foundation R T Hall Trust Marcus Chang Appco Group Randwick City Council Sam Chisholm Arrow ECS Australia Mark Reardon Angela Cho Arthur Phillip Pty Ltd Michael Renford ClearView Wealth Ltd Astron Technology Pty Ltd Res Publica Pty Limited CM & JA Whitehouse Foundation ASX Jessie Ritchie Commercial Projects Pty Limited Aurrum Pty Ltd Road Runner Mobile Tyres Gerry Commerford Australian Chinese Charity Foundation Rotary Club of Dubbo South Inc Matthew Comyn Auzcorp Scentre Group Limited Alan Crawford Alina Azar Secure Parking RJ Crawford Baden J Green Service Pty Ltd Philip Small Crawford’s Casting Baker & McKenzie Speed & Stracey Lawyers Peter Crossings Tim Baldock Marie Spies Cue & Co Pty Ltd Baly Douglass Foundation Peter Stokes Geoff Davis Jayne Baric Tarkett Australia Pty Ltd Deutsche Bank AG Paul Bartlett Valerie Taylor Louise Di Francesco Richard Becker Terra Capital Management Elsie Cameron Foundation Ben & Gloria Sharma Foundation Tony Tesoriero Goodyer Real Estate Leigh Birtles The Hospitals Contribution Fund of Australia Bob Graham Limited Lucie Boulter Hawkesbury Race Club The Mostyn Family Foundation Anne Bowman HCF The RA Gale Foundation Breville Kristiane Herrmann The Sky Foundation Mark Bryce IMB Limited The Stan Perron Charitable Foundation Hilary Marion Cairns John Ingram The Wales Family Foundation Pty Limited Donovan Callaghan John Kean Alden Toevs John T Cameron John Kennedy Toga Pty Limited Capital Australia Pty Ltd Ralph Keyes UBS Australasia Carbon Systems Australia P/L Marcus Laithwaite Unilever Australia Limited John Carter Audrey Lois Lee WCL Management Pty Ltd Challenger Limited Lewin Foundation Robert Whyte Champ Group Services Pty Ltd Lin Huddleston Charitable Foundation Simon Wilkenfeld Charity Greeting Cards Pty Ltd Tony Littlemore Woods Foundation Ross Cicco Steven Lowy Lynn Yager Denis Cleary AM Macquarie Group Foundation Timothy Cohen Robert Mactier Col Johnson & Co Pty Ltd Commonwealth Bank Bernie Connolly Stanley Costigan 46 VICTOR CHANG CARDIAC RESEARCH INSTITUTE

Giugni Family Trust Linda Klarfeld Supporters ($5,000 – $24,999) CONT. Errol Goldberg A Kneubuhler Russ Cottle Golden Fruit Koppers Australia Pty Ltd Coutts Industrial Real Estate Golden Spring Development Pty Ltd Franz Kornfeld C Coxon Good2Give Krispy Kreme Donuts Rick Crabb Julie Goold Landerer & Co Croatian Karlovac Association Frank Goudge Warren Larsen John Croll GPT RE Limited Leda Holdings Pty Ltd Crowe Horwath James Graham Margaret Lederman Crown Property Enterprises Pty Ltd Janet Graham Lend Lease Crown Resorts Limited Greencliff Realty Pty Ltd John Leslie Michael Curcio Greenwoods & Freehills Pty Ltd Peter Leslie Graeme Cureton Jack Grimsley Thomas Lin Noel Darnell Paul Gross Linneys Jewellery Pty Ltd Leonie Davis GSA Services Trevor Loewensohn Timothy Day Claudio Guerrera Logan Family Foundation Eddy DeMarco Michael Gutman Kevin J Lonergan Deutsche Bank Private Wealth Management Eric Haines Jann C. Mackie DEXUS Property Group Janette E Hamilton Maggiotto Building Pty Ltd Margaret Donovan Hancock Prospecting Pty Ltd Mallesons Stephen Jaques Dorothy & Bill Irwin Charitable Trust Matt Hanning Manildra Group Hamish Douglass Martin Hanrahan Manly Warringah Australian Football Club Jennifer Dowling Kim Harding Maroubra Seals Sports & Community Club Ltd John D Duffy Ena May Harries Marsh Insurance Steve Duggan Kleo Hatziladas Boris Martinac Linda Duncombe HCF Marygold Charitable Foundation Phillip Durney Heartbeat of Football McCabes Lawyers Pty Ltd Justin Dwyer Mary Henzell Elizabeth McIntyre Eileen Egan Corinna Ho McIntyre Philanthropic Fund Elder Insurance Peter Homan Mediserve Pty Ltd Elite Fresh Produce Robbie C Horn Dennis Meek Julia Farrell Michael Hudson James Mellon FHG Rogers Pty Ltd A Kai Hung Mercator Supply Co (QLD) Pty Ltd A & M Fini Peter Hutchinson Meridian Corporate Pty Ltd William Finighan Hydro Produce (Aust) Pty Ltd Mersquad Investments Pty Limited Bruce Fink IFS International Finance Services Babak Moini Angela Fleming IMB Ltd Victoria Montano Joanna Fleming Frances A Ingham AC Morgan Christopher Flynn Inghams Services Pty Ltd Norm Moses Justine Forbes Cameron Irving Mulloway Pty Ltd Joyce Forster Patricia Irwin Murphy Foundation Vince Foti Italian Affair Murphy’s Produce Angelos Frangopoulos JECCEM Foundation Jacquie Murray Lars Erik Frankfelt Elizabeth Jewsbury Myer Pty Limited Richard & Jan Freemantle Ralph Johns N & P Romeo Pty Ltd Freshworld K & T Irwin Foundation MJM NAB Fujitsu General (Aust) Pty Limited Sonia Karoll Ian Narev Robert Gardos Sid Kelly J & A Newnham Adriana Gardos Caroline Kennedy Kenneth Ng GDC Accountants Debra Kepitis NGA Marketing Gelatissimo Pty Limited Kerry Ingredients Australia Pty Ltd Andrew Nguyen GFI Australia Pty Ltd Kia Motors Australia Pty Limited Nine Network Australia Camilla Gill Linda Kichno Heather Nobbs ANNUAL REVIEW 2018 47

David Norman Rosina Santamaria Sarina Vignaduzzo Ralph Norris Jeremy Sargeant Vison Pty Ltd Northryrie Pty Ltd – Trustee SCAD Research Inc Australia Rebecca Wachholz NSW Chamber of Fruit & Vegetables Schwartz Foundation Brian Walker Nudie Foods Australia Pty Ltd Maurice Segura Ian Wall Nu-Tech Air Conditioning Pty Ltd Gordon Selig Waterpoint Asset Management Oatlands Golf Club Limited Seven Network (Operations) Limited Watsons Bay Boutique Hotel Sylvia O’Cass Seven West Media Wellington Parkland Pty Ltd Pacific Bondi Management John Sevior Wesfarmers Limited Roslyn Packer Ben Sharma Westfield Corporation James Packer Smeg Australia Pty Ltd Westfield Retail Trust Francesca Packer Barham Souths Sydney Juniors Westpac Banking Corporation Pall Mall Manufacturing Co Pty Ltd Annabel Spring Westpac Institutional Bank Panthers Group St Vincent’s & Mater Health Sydney Willimbury Pty Ltd Andrew Pardoe Ben Stell Alfred Charles Wilson Michele Parker Michael Stening Phillip Wolanski Dominic Parsons Antonia Stephenson Albert Wong Leon Pasternak Maureen Stevenson Yoke-Koon Wong Pater Pty Ltd Alice Styles Wyndham-Chapman Investment George Penklis Simon Swanson Company Pty Ltd Penrith City Council S & V Swanson XL Fruit & Vegetable Pty Ltd Esmond Pereira Sydney Market Limited Ping Chuen Yick Perpetual Trustee Company Limited Sydney Markets Foundation Inc Yoba Pty Ltd Filippo Perri Victoria Taylor Raymond Young PKF Chartered Accounts Terra Capital T Zammit Stephen Pocklington Lillian Tesoriero Zap Nominees Pty Ltd Saverio Polistina The Alexandra & Lloyd Martin Family Foundation Bin Bin Zhang Carol Pollock The Dick and Pip Smith Foundation Steven Porges The Jenour Foundation Bequests Brent R Potts The Johnson Family Foundation Mark Powell The Lewis Foundation Estate of the Late John Baker Prime Partners The Myer Family Company Limited Estate of the Late Ilze Baltins Professional Advantage The O’Halloran Foundation Estate of the Late Nola Bennetts Fong Pui Yin The Patricia Dukes Foundation Estate of the Late Ralph Carrick QBE Australia The Wolanski Foundation Estate of the Late Ivan Crnkovic Ralph Johns Pty Ltd Jennie Thomas AM Estate of the Late Bob Henry De Groot RARE Infrastructure Millie Tong Estate of the Late Sheila E Finlayson Patrick Regan Phillip Townsend Estate of the Late Jennifer Goodhew Anne Reid Michael Traill Estate of the Late Eric Harrison Res Publica Pty Limited Trazoy Pty Ltd Estate of the Late Jane J Holland Denis Richmond Trim Fresh Leichhardt Pty Ltd Estate of the Late Michael Hopkins Andrew Roberts Tristate Produce Merchants Pty Ltd Estate of the Late Joyce Johnston Frank Robertson Colin Tuck Estate of the Late Moira Marlin Dennis L Robinson Turnbull Foundation Estate of the Late Thomas Martindale Judith Rose UBS Estate of the Late Kevin Marcus McGuinness Lance Rosenberg Ungarie District Bowling Club Estate of the Late Rex Morriss Stanley Roth AM Unilever Australia Limited Estate of the Late Daphne Muriel Redman John Rowan Tony Valos Estate of the Late Nancy Roberts Paul Roy Jamie Vandenberg Estate of the Late Shirley Isabel Robertson S & W Mi-Lees Pty Ltd Bruce Vaughan Estate of the Late James Sinapius Sam the Paving Man Pty Ltd Vaux Family Foundation Pty Ltd Estate of the Late Annette Geraldine Van Dop Jamie & Renee Samaha Patrick Versace Estate of the Late Ronald White Howard Sandler Paul Verscheur 48 VICTOR CHANG CARDIAC RESEARCH INSTITUTE

Honorary Life Governor Profield Foundation (2014) SCIENTIFIC ADVISORY BOARD Michael Renford (2014) Professor Doug Hilton (Chair) Her Royal Highness Crown Mimi Wong (2014) Walter and Eliza Hall Institute, Australia Princess Mary of Denmark Ruth Zukerman (2016) Professor John Chalmers Patti Chong (2016) The George Institute for Global Health, Australia IMB Community Foundation (2017) Professor Andrew P. Feinberg Patrons Guy Fowler (2018) Johns Hopkins University School of Medicine, Ann Chang USA Steven Lowy Professor John F. Keaney Jr Honorary Life Members University of Massachusetts Medical School, USA Fiona Coote AM (2001) Professor Eduardo Perozo Past Patrons Kerry James AM (2004) University of Chicago, USA John Kean OAM (2010) The late Kerry Packer AC Professor Janet Rossant John McGuigan (2010) The late Hon Neville Wran AC QC The Hospital for Sick Children, Canada Barbara Ell OAM (2014) David Craig (2018) FACULTY REVIEW COMMITTEE Ambassadors Sr Anthea Groves RSC, OAM (2018) Professor John Shine (Chair) UNSW Sydney and Garvan Institute John Laws CBE (2001) of Medical Research The late Amana Finley (2001) Committees Professor Michelle Haber Children’s Cancer Institute of Australia Ken Laing AM (2001) COMMITTEE FOR WESTERN SYDNEY Professor Bob Graham The late Alan David (2002) Victor Chang Cardiac Research Institute Crane Group Limited (2002) Louise Di Francesco (Chair) Alan Crouch Professor Peter Gunning Steve Costi Seafoods (2003) UNSW Sydney Vince Foti Crestbrook Mountain Springs (2003) Professor John Rasko Ariane Gallop Baker & McKenzie (2004) Centenary Institute Brendon Noney Schute Bell Badgery Lumby (2005) Professor Phil Robinson David and Diana Ritchie (2005) Frank Oliveri Children’s Medical Research Institute Scott and Rhonda Gibbons (2006) Danny Rezek Russell and Julieanne Cooper (2007) Craig Wellman John and Margaret Ingram (2007) Tony Zappia Ralph and Lorraine Keyes (2008) YOUNG APPEALS COMMITTEE Guinness Peat Pty Ltd (2008) Jonathan Henry (Chair) Cameron Irving (2009) Marcus Chang Deutsche Bank (2009) Alistair Booth Club Marconi (2009) Adam Buist LK Jewellery (2009) James Camilleri Mark Vincent (2009) Daniela Elser Steve Quinn (2011) Evelyn Yeung Cobram Estate (2011) Joel Barbuto Anne-Marie Allgrove (2011) Timothy Barrett United Airlines (2011) Alistair Booth Virgin Airlines (2012) James Camilleri Terry McCabe (2012) Daniela Elser Mark Ryan (2012) Vanessa Gilbert HCF (2012) Toby Harrison Michele Parker (2012) Alex Hart Emma Quick (2012) Laura Jayes Randwick City Council (2013) Caity McLoughlin Kia Motors (2013) Simon Raftery Ryan Stokes (2013) Sarah Stavrow Craig Marshall (2013) Sharlene Melville (2013) Kate Ritchie (2013) Support Life-Saving Heart Research

Be part of the solution One of the most life-changing ways you can make a difference is to support research into heart disease.

You’re an important piece of the puzzle that is helping shape the future. With your support, our researchers can continue to find cures for heart disease.

Donate today – help us solve the unsolved and prevent heartbreak happening to you.

Victor Chang Cardiac Research Institute Lowy Packer Building 405 Liverpool Street Darlinghurst NSW 2010 For more information or to show your Australia support today, please call T (+61) 02 9295 8600 E [email protected] 1300 842 867 www.victorchang.edu.au or visit www.victorchang.edu.au @VictorChangInst

Victor Chang Cardiac Research Institute ABN 61 068 363 235 Lowy Packer Building 405 Liverpool Street Darlinghurst NSW 2010 Australia T (+61) 02 9295 8600 1300 842 867

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