victor chang cardiac 2010 research institute annual REPORT HEART FACTS Contents

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02 Our Institute 03 A Message from the Mary Aikenhead Ministries 04 2010 Chairman’s Report 07 2010 Executive Directors Report 08 Scientific Advisory Board 10 Board of Directors St. Vincent’s Health Ltd victor chang cardiac — research institute BOARD 12 VCCRI Honourees Chairman 14 Highlights 2010 Mr. Steven Lowy, AM CHAIRMAN, Finance COMMITTEE — Mr. John Kean 19 Publications CHAIRMAN, Appeal COMMITTEE 22 Awards and Achievements VCCRI MRS. LOUISE DI FRANCESCO 23 Symposia and Lecture Series organisational — 25 Financials structure 26 VCCRI Health Check Booth University of NSW Vice Chancellor: 28 Research Divisions VCCRI scientific advisory board Professor Fred Hilmer, AO 30 School Science Awards 32 Fundraising Executive DIRECTOR 35 Bequests PROFESSOR ROBERT GRAHAM, AO

VCCRI Research Divisions

Chief Operating Officer

The relief of pain and suffering and AdministratiON the promotion of well-being, through Core Facilities an understanding of the fundamental Essential Services mechanisms of cardiovascular biology in health and disease.

VCCRI ANNUAL REPORT 2010 01. OUR INSTITUTE A MESSAGE FROM THE MARY AIKENHEAD MINISTRIES

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With donated funds, St. Vincent’s Hospital established the Victor Chang Cardiac Research Institute, which was launched on February 14, 1994. The Trustees of Mary Richard Harpham Foreword Aikenhead Ministries Chairman, Trustees of — Mary Aikenhead Ministries would like to congratulate On 1 July 2009, Mary both Steven Lowy and Bob Aikenhead Ministries Graham on the continued was established by the success of the Institute. Congregation of the Religious The contribution it continues Sisters of Charity of Australia, to make to the health and to assume the governance research communities is role previously held by the extraordinary. The Trustees Congregation in relation are very grateful that people to various health and aged of great commitment and care, research, education ability (both Directors and and welfare ministries, staff) have contributed so including the Victor Chang much to ensure that the Cardiac Research Institute. Institute continues to excel, developmental Biology 07 notwithstanding the many The name Mary Aikenhead challenges it faces. Molecular Cardiology & Ministries is both a tribute Biophysics 06 to, and reminder of, the On behalf of the Trustees of Molecular genetics extraordinary work and Mary Aikenhead Ministries, ministry of Mary Aikenhead, I am pleased to commend to the Foundress of the Sisters you the 2010 Annual Report Structural & 05 Computational Biology of Charity, who dedicated her of Victor Chang Cardiac life to service of the poor. Research Institute.

Administration & FInance 04

Richard Harpham Chairman, Trustees of reception, stores, 03 loading dock & Mary Aikenhead Ministries cryogenics

Biocore Facility & Aquarium 01

02. VCCRI ANNUAL REPORT 2010 VCCRI ANNUAL REPORT 2010 03. 2010 Chairman’s Report

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It’s an enormous challenge In addition to excellence in Our efforts to meet this but one this Institute was research the Institute also challenge are ably led by the inspired to undertake by the fulfils an important role in board’s Appeals Committee, man whose name it bears – raising awareness of heart now chaired by new board the renowned heart disease. In 2010 we launched member, Louise Di Francesco, Victor Chang. 2011 marks the the Victor Chang Health who took over from John 20th anniversary of Victor’s Check Booth. The booth is McGuigan who served in passing and I think it’s fair designed to encourage people this role for many years. to say that his ambition to have their blood pressure, One of the major fundraising to establish a centre for cholesterol and blood sugar events each year is our excellence in this field is levels tested to increase their Steven Lowy awareness of cardiovascular traditional ‘Heart-to-Heart Chairman being more than honoured Ball’ and last year we were through the work that is risk factors. The booth has been trialled at a number of honoured that the Prime — carried out every day in the venues in and around . Minister, Julia Gillard, made new building which is now This is just one example of a special effort to attend. Each year this report provides home to the Institute. me with an opportunity to how we are continually taking put the many activities of the The case to do more and our message to the wider Institute into some context – more research into heart community. She spoke about the to explain, at a high level, what chose the VCCRI to be their article ‘Could it Happen to You’ disease is a compelling one Of course, to undertake our we do, why we do it, and what lasting impact Victor charity partner in a promotion in the SMH Good Weekend for two reasons. The first is research and community have been the results. that it is an enormous problem Chang has had on the launching their new car. magazine. The journalism programs the Institute faces - cardiovascular disease (CVD) awards are an initiative of the an ongoing challenge to lives of many Australians It’s also an opportunity is Australia’s biggest killer, The Commonwealth Bank Marketing and Communication carefully manage its budget and her presence also to recognise the outstanding resulting in more than 50,000 generously agreed to print our Committee formed during the and undertake a range of contribution so many people deaths each year. provided an opportunity message about the warning year and led by board member make to help us achieve fundraising activities. to raise some important signs of heart attacks, and Ms Jill Margo. those results. The second is that we can what to do until help arrives, This challenge is made all the prove that the sort of research issues, like the on the back of their envelopes On Mothers’ Day last harder by a self-perpetuating So let me begin with the big being done by this Institute fundraising challenge during 2010. year we urged Australian problem inherent in the current picture. is going a long way in women to recognise the system of funding for medical I just mentioned. overcoming the problem. Another successful event was early warning signs for heart The Victor Chang Institute is research institutes like the Victor this year’s Crabfest charity attack by having their risk a research institute. We exist Yes, the problem is enormous. Chang. Fundamentally, there is In 2010 the Institute welcomed lunch organised by VCCRI factors checked regularly. to do the hard, grinding work But answers are being found. an ever-widening gap between a generous new supporter - Ambassador Cameron Irving This campaign has a special of better understanding the Priceline. Priceline donated a Fewer people are dying. the federal grants received for and his committee, and significance for the VCCRI causes of heart disease and to research and the limited funding proportion of the sale price of the Victor Chang Award for as our friend and colleague, bridge the gap between that available for indirect costs that every bottle of Nature’s Own Excellence in Cardiovascular finance manager Monica and Blackmore’s Fish Oil to understanding and a clinical are necessary to undertake that Journalism that was launched O’Loughlin died suddenly heart disease research. Our application that will make a More people are living research. When we receive a at the VCCRI ball in 2010. Today of a heart attack. A 51-year- partnership with Priceline will material difference for patients. longer lives, happier lives much-needed grant to pursue Tonight Perth reporter Mark old mother of five, Monica continue in 2011 when they Gibson received the Award for delayed seeing a doctor about I want to emphasise the thanks to the kind of an important research project, launch their new ‘Sisterhood’ Excellence in Cardiovascular her condition despite having hard work aspect of the we then have to generate new initiative that will focus on the work that happens here. Journalism for his story about some classic symptoms of Institute because it is the income to fund the essential heart health of women. items to actually carry it out – Perth radio announcer Ian a coronary artery disease. It reality. Big breakthroughs In Australia the death rate for is hoped that 2011 will see are rare. When they do not just scientific equipment We also thank KIA for Blackley who suffered a heart all major types of CVD has and administrative and legal attack during his live radio show. the start of a yearly lunch come, they are usually the fallen by 80% since the 1960s including the VCCRI in their expenses, but also mundane Ambassador’s Program. Each Fred Witsenhuysen received the to honour Monica, called result of literally years of toil – an advance due directly to ‘Women and Heart Disease’, but equally essential services of their Ambassadors is given regional award for his article that by dedicated researchers– advances in medical research. which aims to further raise like lighting and telephones. the use of a KIA for at least one appeared in the Sunshine Coast like building a massive In 2010, advances like these awareness that cardiovascular year and, in our case, we have Daily on his own experience building brick by brick. achieved by the Victor Chang disease affects not just men been able to use it to transport with bypass surgery, and Ms Institute were reported in but women too. Four times leading international journals our Health Check Booth from Janet Hawley received an honourable mention for her more women die from heart such as Nature and Nature venue to venue. KIA also disease than breast cancer. Structural Biology. 04. VCCRI ANNUAL REPORT 2010 VCCRI ANNUAL REPORT 2010 05. 2010 Chairman’s Report 2010 Executive director’s Report

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I’d like to take this opportunity through the provision of services, On behalf of the board, towards nutrients. These Early in 2010, the Institute’s to acknowledge and thank such as that provided by Anne- I would like to extend our motors are the most energy progress was evaluated by our longterm friend and Marie Allgrove and Ms Mary thanks to the many people efficient motors known and our ‘blue ribbon’ international supporter, Aldo Santamaria, Saywell and their team at Baker and organisations that help us are used to spread bacterial Scientific Advisory Board who staged a very successful McKenzie who offer pro bono continue our work. All of us at infection. which provided a very Sportsman’s Lunch for the legal advice to the Institute. the Institute – the board, our favourable report on our This discovery solves a riddle Institute, and to Sharon and executive team, and research progress over the last five that has been perplexing Andrew Cooper who are Finally, I would like to and support staff – value this years. The Board also provided scientists for decades and important recommendations donating part of the proceeds acknowledge the ongoing enormously, and we look could have important practical for the Institute to progress to of their book How to Grow commitment, support forward to working with you implications through the the next stage, which led to Superfoods to the Institute. and advice provided by into the future. the Trustees of the Mary Professor Robert M. Graham development of unique new the recruitment of new faculty Executive Director Despite the difficulties we Aikenhead Ministries, Board therapies for the treatment member Dr Kazu Kikuchi, an face to continually win research Member Sr Anthea Groves — of some of our most serious international expert on heart muscle regeneration. Currently, grants and then find the funds and Appeals Committee diseases, including bacterial in the US, he will be moving to to carry out that research, Member, Sr Clare Nolan. I am pleased to share with you endocarditis that destroys my enthusiasm and excitement heart valves and rheumatic Australia to start working at the the VCCRI financial position Steven Lowy It has been another successful about our current research and fever that causes inflammation Institute early 2011. remains sustainable. We had AM, BComm (Hons) budgeted for a loss in 2010 of year for Victor Chang, one the many accomplishments of heart muscle. I would like to most sincerely about $2.1 million. However, in which we have made over the past year. In addition thank all VCCRI donors and I am pleased to announce further inroads into better to launching our major supporters, as well as our we completed the year with understanding one of the community health initiative, Board and Appeals Committee the Victor Chang Health This discovery solves a loss of only $808,596. greatest health challenges for their continued recognition of our times.We continue to Check Booth, this year was a riddle that has been and unflagging support of our This performance was driven find answers that make a real also a record year in terms of perplexing scientists work–without their hard work by better-than- budgeted grant difference to people’s lives new grant funding. A total of for decades. and extraordinary generosity and other income and stringent and this gives us hope and $13 million in new NHMRC none of our achievements grant funding was awarded would be possible. I would cost control. I would like to inspiration to continue the work. Associate Professor Diane acknowledge the leadership of to the Institute over a five- also like to acknowledge the year period, which included Fatkin and her team found that, extraordinary work done by the chair of the board’s finance contrary to accepted dogma, committee, John Kean, who the renewal of our NHMRC Britt Granath, our Science a regular exercise program Policy Officer, during my has been a tireless contributor program grant (over $9 million) in addition to treatment tenure as President of the to the Institute over many years. to study how defects in the development and function of with the beta-blocking drug Association of Australian It is not possible to thank It has been another successful year heart muscle cells can lead to carvedilol, retards rather than Medical Research Institute every organisation and for Victor Chang, one in which we structural heart malformations. accelerates the development from 2008 to 2010. individual that supports our We also published 3 book of dilated cardiomyopathy, a serious genetic condition of Finally, it is of note that work but it is important for have made further inroads into better chapters and 57 journal heart muscle that commonly 2011 will be a very special them to know how much we papers, many of these in understanding one of the greatest leads to the need for a heart one for the Institute and its value their contribution. Quite the highest-ranking journals transplant. supporters, as we will be simply, without it the Institute health challenges of our times. including Nature and Nature commemorating the 20th would not be here doing the Medicine. Amongst our many Associate Professor Thomas anniversary of the untimely life-saving work that it does. important discoveries this year, Preiss, in collaboration with death of Victor Chang. I hope This support is provided through I would like to highlight three: Garvan Medical Research you will join me in taking the time to commemorate Dr financial assistance, but also Dr Daniela Stock and her Institute and international researchers, discovered a new Chang as we continue his work postdoctoral fellow, Dr in eradicating heart disease. Lawrence Lee, discovered way of potentially reversing the secrets behind one of certain cancers using a new nature’s most extraordinary class of genes known as biological machines. The ‘microRNAs’— work that is researchers have discovered at the cutting edge of genetic the mechanism behind the tiny research. Professor Robert M. Graham motors in the tail of bacteria AO, FAA, MBBS (Hons), MD, that allow them to swim FRACP, FACP, FAHA

06. VCCRI ANNUAL REPORT 2010 VCCRI ANNUAL REPORT 2010 07. SCIENTIFIC ADVISORY BOARD

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Every five years the VCCRI undergoes a rigorous and stringent review by an international panel of experts in medical research. These valued consultants exhaustively evaluate our research programs and provide advice on our future research directions and strategy. We sincerely thank our panel for their generous time and advice which ensures our research can continue to be counted amongst the best in the world.

Scientific Advisory Professor Physiology & Board Members Biophysics, University of California, a member of the Professor Doug Hilton, Howard Hughes Medical (Chair), Director Walter & Institute and of the National Eliza Hall Institute, Melbourne, Academy of Sciences, USA. Research Professor of Medical Biology and Head, Professor Janet Rossant, Dept of Medical Biology, The Hospital for Sick Children, University of Melbourne, Toronto, Canada, Professor, and a fellow Australian Departments of Molecular 02 Academy of Science. Genetics, Obstetrics/ Gynaecology & Paediatrics, 01 Associate Professor Diane Fatkin and Professor Witold Filipowicz, University of Toronto, Chief of Liz Yeo Friedrich Miescher Institute Research, Research Institute, 02 Dr. Daniela Stock and Dr. Lawrence Lee Basel, Switzerland. Professor Distinguished Investigator, with the X-Ray crystallography machine of Biochemistry, member Canadian Institutes of Healthv of the European Molecular Research. Member of the investigators in independent Biology Organisation and the American Academy of Arts positions is exemplary. The Academia Europea. & Sciences, USA & Foreign staff and the students of Associate, National Academy the VCCRI have established Professor Lily Jan, of Sciences, USA. a highly collegial research Dept of Physiology & atmosphere, in which there Biophysics, University of Professor Stephen Vatner, is uniform excitement about California, San Francisco, Chairman, Dept Cell Biology being part of an outstanding USA. Professor Jan is the & Molecular Medicine at Institute. Given the challenges Jack and DeLoris Lange University of Medicine that many institutions around 01 & Dentistry, New Jersey the world face in building Medical School. a translational research program, the VCCRI is doing Findings an outstanding job. In short, the VCCRI has developed The Board’s major findings admirably and is at the were that: “The Institute has most exciting point in its developed to be one of the fifteen-year journey. Major best known and most highly recommendations included respected medical research recruitment of additional institutes in Australia and has research groups, increasing an international reputation the Institute’s endowment for its cardiac research. The and enhancing support of VCCRI has an excellent faculty, core facilities and additional and support of younger translational research efforts.”

08. VCCRI ANNUAL REPORT 2010 VCCRI ANNUAL REPORT UPDATE 2010 09. Board of Directors

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The successful operations of the VCCRI are Mr. John McGuigan LLB heavily reliant upon the dedication, commitment — and vision provided by the Board of Directors – Life Member VCCRI and subsidiary committees. – Co-founder Hunter Bay Partners – Chairman, White Energy

Mr. Chum Darvall Mr. Angelos Frangopoulos BA, FFin, FAICD BA (Comm), MAICD, JP — — – Chief Executive Officer, – CEO Australian News Channel Deutsche Bank Aust & NZ – Member of the Council of Charles – Council Member, Business Sturt University Council of Australia – Chairman, Australia Day – Board Member, Wilson HTM, NSW Council AFMA, Centre for Independent Mr. Steven Lowy Mr. David Craig Studies, Australian Theatre for Professor Leslie D Field Chairman BEC, FCA, CTFP Young People & Others BSc, PhD AM, BComm (Hons) — — — – Chief Financial Officer, – Deputy Vice Chancellor (Research) – Life Governor VCCRI Commonwealth Bank University NSW – Joint Chief Executive Officer – Member VCCRI Finance – Director New South Innovations, Westfield Group Mr. John Kean Committee Australian Technology Park – President of the Board of FCA, FAICD Innovations Trustees Art Gallery, NSW — – The Cooperative Research Centre – Director, Lowy Institute for – Life Member VCCRI for Spatial Information International Policy – Executive Chairman Pinpoint Pty Ltd. – Smart Internet Technology – Member Prime Minister’s Cooperative Research Centre – Founding Partner of WHK Business Government Advisory Greenwoods, Chartered Accountants – Member Australian Institute of Group on National Security Population Ageing Research – Independent Business Advisor and – Chairman, Board of Management Leaders Forum Director of various businesses for the Associate Degree of Policing Practice(ADPP). – Chairman Finance Committee Sr. Anthea Groves Ms. Jill Margo Dr. Gary H. Weiss OAM, RSC, RN LHA AM, BA (Hons) LLB (Hons), JSD Dip. of Nursing Administration — — — – Medical Journalist, Australian – Director Ariadne Australia Ltd, Tag – Member of the Congregation Financial Review Pacific Ltd, Premier Investments Ltd of the Sisters of Charity – Best Selling Author and Biographer – Chairman of Coats plc – Patient Liaison Officer, St Vincent’s Hospital Sydney

Mrs. Barbara Ell Professor Robert M. Graham Mrs. Louise Di Francesco — AO, FAA, MBBS (Hons), MD, — – Life Governor, Member of the FRACP, FACP, FAHA – Chair, Victor Chang Appeals VCCRI Appeal Committee — Committee – Chair, Victor Chang Annual Ball – Executive Director, VCCRI – Director Verve Communications – Specialist in PR, Media Communications, Issues & Crisis Management

10. VCCRI ANNUAL REPORT 2010 VCCRI ANNUAL REPORT 2010 11. Vccri Honourees

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The Heart and Soul of the VCCRI Life Governors Ambassadors — — — Our voluntary Committee Members, Patrons, Life Governors, Ambassadors, – Abigroup – Baker & McKenzie Life Members, Donors and Supporters are the heart and soul of the VCCRI. – ANZ Bank – The Crane Group Their dedication, commitment and encouragement of our research is – Mr. Sam Chisholm – The late Mr. Alan David unconditional. We thank them for their generosity, enormous time and – Citigroup – The late Amana Finley the expertise they provide so willingly and freely. – Mr. John David – Mr. John Laws, CBE – Mrs. Barbara Ell – Mr. Ken Laing, AM – Lady Mary Fairfax, AC,OBE – Schute Bell Badgery Lumby Patrons Honorary Life Governor – The late Lady Finley – Steve Costi Seafoods — — – The Freedman Foundation – Mr. & Mrs. Scott & Rhonda Gibbons – Mrs. Ann Chang – Her Royal Highness Crown Princess – The Freshest Group – Mr. & Mrs. Russell & Julieanne Cooper Mary of Denmark – The Hon Neville Wran, AC, QC – Mr. Frank Lowy, AC – Mr. & Mrs. John & Margaret Ingram – Mr. Steven Lowy, AM – Mr. & Mrs. Ralph & Lorraine Keyes Past Patron – Mr. James Packer – Guinness Peat Group — – National Australia Bank – Club Marconi – The late Mr. , AC – Mr. Robert Oatley – LK Jewellery – Strathfield Group Limited – Mr. Cameron Irving – Mr. Ziggy Switkowski – Deutsche Bank – Telstra Corporation – Mrs. Jennie Thomas, AM – Mr. Lance Rosenberg Honorary Life Members — – Mr. Mark Johnson, AO – Ms. Fiona Coote, AM – The late Mr. Ken Lee 02 – Mr. Kerry James, AM – Mr. & Mrs. David & Diana Ritchie – Mr. John Kean – The Atlantic Philanthropies – Mr. John McGuigan – Ingham Enterprises – Mrs. Roslyn Packer, AO – Mr. & Mrs Gerry & Young Ambassador Award Wendy Commerford — – Mr. Lionel Lee – Mr. Mark Vincent

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01 Steven Lowy with VCCRI Life Governor Lionel Lee, wife Lisa Lee & mother Yenda Lee. 02 Steven Lowy with VCCRI Life Governors Gerry & Wendy Commerford. 12. VCCRI ANNUAL REPORT 2010 VCCRI ANNUAL REPORT 2010 13. highlights 2010

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New methods found to combat Putting the brakes on bacterial common heart muscle condition infection — — Associate Professor Diane Fatkin and her Drs Daniela Stock and Lawrence Lee, in the team in the Molecular Cardiology Division, Structural and Computational Biology Division, found two new approaches that could be made an important discovery that may help used to prevent dilated cardiomyopathy stop bacterial infection in its tracks, by revealing (DCM), a common disease of the heart the first clear picture of how the tiny motors muscle that reduces the pumping action that drive bacteria operate. of the heart. The tiny motors, called flagellar, are the most The research revealed that regular moderate energy efficient motors known, and allow exercise from a young age could help prevent bacteria to manouvre quickly towards nutrients rather than contribute to the common genetic and away from toxins, which is crucial to the heart condition, that can lead to heart failure and spread of bacterial infection. sudden death. Scientists around the world have been trying As well as a regular exercise program, the beta to determine how these tiny motors worked blocking drug carvedilol, commonly used to for around 30 years, making the discovery treat patients with symptomatic heart failure, a massive coup for Victor Chang scientists, was also found to reduce the development of led by Dr Stock. The study was published in DCM, if taken from a young age. the prestigious scientific journal Nature, in August 2010. A/Professor Diane Fatkin, said the results of the study are exciting. The finding could have significant implications for the treatment of potentially life-threatening diseases such as bacterial endocarditis that “Rather than dealing with the end destroys heart valves, and rheumatic fever that stage of heart failure, which places an causes inflammation of heart muscle. enormous economic and social burden Professor Bob Graham said of the research: on our community, we can recommend patient therapies and exercise programs “This work really unifies the results of that will slow down the progression of decades of international scientific study, the disease from an early age.” and is a coup for Australian science. The study was published in the international The fact we can now understand how journal Circulation Research in February 2010. these bacteria generate movement and change direction is of critical importance, not only for biologists around the world, but for the future design of nano-machines as well.”

01 Dr. Daniela Stock (right) 14. VCCRI ANNUAL REPORT 2010 VCCRI ANNUAL REPORT 2010 15. highlights 2010

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Busy mums urged to ‘take heart’ Victor Chang Awards for — Excellence in Cardiovascular On the first anniversary of the passing Journalism of former colleague and finance manager — Monica O’Loughlin in May, Australian These awards are the first in Australia to women were urged to recognise the early reward excellence in reporting and raising warning signs for heart attack and have awareness about heart disease. The inaugural their risk factors checked regularly. awards were presented in 2010 at the Victor On average, heart disease kills almost 30 Chang Annual Ball and despite being the first Australian women each day or around 204 year, a large number of entries were received. women each week. Putting this in perspective, The Regional Media Award was presented to Australian women are 4 times more likely to 85 year old Fred Witsenhuysen for his article die of heart disease than breast cancer. published in Queensland’s Sunshine Coast Daily, “Facing up to heart disease”. The Spokesperson Associate Professor Diane Metropolitan Media Award was presented Fatkin, said that educating women about to 7 Perth Today Tonight’s Mark Gibson for the warning signs of heart attack and getting his story on MIX FM announcer Ian Blackley’s regular blood pressure and cholesterol tests, heart attack on air. An honourable mention is just as important as getting a regular went to Fairfax Journalist Ms Janet Hawley mammogram or pap smear, particularly if for her article “Could it Happen to You?” you have a family history of heart disease. which appeared in the Good Weekend.

“We need to change the perception that only old, overweight men die of heart attacks. The reality is, just as many women die of heart disease, and they are often tragically taken at the prime of their life, leaving behind husbands, children and families.”

In 2011, the Monica O’Loughlin Women and Heart Disease Women’s Lunch will be inaugurated. 01

01 2010 VCCRI Journalism Award Winner Mark Gibson (right) with his subject, Perth radio announcer Ian Blackley, who suffered a heart attack on air. 02 A/Professor Diane Fatkin & team 03 Monique Ohanian (left) 02 16. VCCRI ANNUAL REPORT 2010 VCCRI ANNUAL REPORT 2010 17. PUBLICATIONS 2010

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Beilharz TH, Humphreys DT, Clarke OB, Caputo AT, Hill AP, Du H, Davidson PM, Everett B, Preiss T. miRNA effects on mRNA Vandenberg JI, Smith BJ, Salamonson Y, Zecchin R, Rolley closed-loop formation during Gulbis JM. Domain reorientation JX, Newton PJ, Macdonald PS. translation initiation. Prog Mol and rotation of an intracellular Assessment of a self-administered Subcell Biol. 2010; 50:99-112. assembly regulate conduction in adapted 6-minute walk test. J Kir potassium channels. Cell 2010; Cardiopulm Rehabil Prev. 2010; Börngen K, Battle AR, Möker 141:1018-29. 30 :116 -120. N, Morbach S, Marin K, Martinac B, Krämer R. The Combes AN, Spiller CM, Harley Granados-Riveron JT, Ghosh TK, properties and contribution of the VR, Sinclair AH, Dunwoodie SL, Pope M, Bu'Lock F, Thornborough Corynebacterium glutamicum Wilhelm D, Koopman P. Gonadal C, Eason J, Kirk EP, Fatkin D, MscS variant to fine-tuning of defects in Cited2-mutant mice Feneley MP, Harvey RP, Armour osmotic adaptation. Biochim indicate a role for SF1 in both testis JA, David Brook J. Alpha-cardiac Biophys Acta. 2010; 1798:2141-9. and ovary differentiation. Int J Dev myosin heavy chain (MYH6) Biol. 2010; 54:683-689. mutations affecting myofibril Butler TL, Esposito G, Blue GM, formation are associated with Cole AD, Costa MW, Waddell LB, Corry B, Hurst AC, Pal P, Nomura T, congenital heart defects. Hum Mol Walizada G, Sholler GF, Kirk EP, Rigby P, Martinac B. An improved Genet. 2010;19(20):4007-16. Harvey RP, Winlaw DS. GATA4 open-channel structure of MscL mutations in 357 unrelated patients determined from FRET confocal Gucev ZS, Tasic V, Pop-Jordanova with congenital heart malformation. microscopy and simulation. J Gen N, Sparrow DB, Dunwoodie Genet Test Mol Biomarkers. Physiol. 2010; 136:483-94. SL, Ellard S, Young E, Turnpenny 2010;14:797-802. PD. Autosomal Dominant Corte TJ, Wells AU, Gatzoulis MA, Spondylocostal Dysostosis in Three Chandar S, Yeo LS, Leimena Cramer D, Ward S, Macdonald Generations of a Macedonian C, Tan JC, Xiao XH, Nikolova- PS, Dimopoulos K, Wort SJ. Non- Family: Negative Mutation Analysis Krstevski V, Yasuoka Y, Gardiner- invasive assessment of pulmonary of DLL3, MESP2, HES7, and LFNG. Garden M, Wu J, Kesteven S, blood flow using an inert gas Am J Med Genet 2010; Part A Karlsdotter L, Natarajan S, Carlton rebreathing device in fibrotic lung 152A:1378–1382. A, Rainer S, Feneley MP, Fatkin disease. Thorax. 2010; 65:341-345. D. Effects of mechanical stress and Hayward CS, Peters WS, carvedilol in lamin A/C-deficient Cropley JE, Suter CM, Beckman Merry AF, Ruygrok PN, Jansz P, dilated cardiomyopathy. Circ Res. KB, Martin DI. CpG methylation of O'Driscoll G, Larbalestier RI, Smith 2010; 1063:573-582. a silent controlling element in the JA, Ho B, Legget ME, Milsom murine Avy allele is incomplete FP. Chronic extra-aortic balloon Chih S, Macdonald PS, Feneley and uresponsive to methyl donor counterpulsation: First-in-human MP, Law M, Graham RM, supplementation. PLoS One. 2010; pilot study in end-stage heart McCrohon JA. Reproducibility of 5:e9055. failure. J Heart Lung Transplant. adenosine stress cardiovascular 2010; 29:1427-32. magnetic resonance in multi-vessel Davidson PM, Macdonald PS, symptomatic coronary artery Newtown PJ, Currow DC. End Hentze MW, Preiss T. The REM disease. J Cardiovasc Magn Reson. stage heart failure patients – phase of gene regulation. Trends 2010; 12:42. palliative care in general practice. Biochem Sci. 2010; 35:423-6. Aust Fam Physician. 2010, Chiu J, Tactacan CM, Tan SX, Lin 39:916-920. Hildenbrand ZL, Molugu SK, RC, Wouters MA, Dawes IW. Cell Stock D, Bernal RA. The C-H cycle sensing of oxidative stress Diehl F, Brown MA, van Peripheral Stalk Base: A Novel in Saccharmoyces cerevisiae by Amerongen MJ, Novoyatleva T, Component in V1-ATPase oxidation of a specific cysteine Wietelmann A, Harriss J, Ferrazzi Assembly. PLoS ONE 2010; 5: residue in the transcription F, Böttger T, Harvey RP, Tucker e12588. factor Swi6p. J Biol Chem.2010; PW, Engel FB. Cardiac deletion of 286:5204-5214 smyd2 is dispensable for mouse heart development. PLoS One. 2010; 5:e9748.

18. VCCRI ANNUAL REPORT 2010 VCCRI ANNUAL REPORT 2010 19. PUBLICATIONS 2010

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Jabbour A, Macdonald PS, McConoughey SJ, Basso M, Schonrock N, Ke YD, Humphreys Weber T, O'Rourke MF, Martinac B, Rohde PR, Battle AR, O'Rourke MF, Adji A. Central Keogh AM, Kotlyar E, Mellemkjaer Niatsetskaya ZV, Sleiman SF, DT, Staufenbiel M, Ittner LM, Lassnig E, Porodko M, Ammer Petrov E, Pal P, Foo AFW, Vasquez pressure and pulse wave S, Coleman CF, Elsik M, Krum H, Smirnova NA, Langley BC, Preiss T, Götz J. Neuronal M, Rammer M, Eber B. Pulse V, Huynh T. and Kloda A, Studying amplification in the upper limb. Hayward CS. Differences between Mahishi L, Cooper AJ, Antonyak microRNA deregulation in response waveform characteristics predict mechanosensitive ion channels Hypertension. 2010; 55:e1-2. beta-blockers in patients with MA, Cerione RA, Li B, Starkov A, to Alzheimer's disease amyloid- cardiovascular events and mortality using liposomes. Methods Mol. [author reply e3]. chronic heart failure and chronic Chaturvedi RK, Beal MF, Coppola beta. PLoS One. 2010; 11;5:e11070. in patients undergoing coronary Biol. 2010; 606:31-53. obstructive pulmonary disease: a G, Geschwind DH, Ryu H, Xia L, angiography. J Hypertens. 2010; O'Rourke MF. The CHARM of a randomized crossover trial. J Am Iismaa SE, Pallos J, Pasternack Sparrow DB, Sillence D, Wouters 4:797-805. Commentaries & Editorials Paradox. J Am Coll Cardiol. 2010; MA, Turnpenny PD, Dunwoodie Coll Cardiol. 2010; 55:1780-1787. R, Hils M, Fan J, Raymond LA, 55:257. Marsh JL, Thompson LM, Ratan SL. Two novel missense mutations Williams H, Pease RJ, Newell LM, Macdonald PS. Heart failure with Kung C, Martinac B, Sukharev RR. Inhibition of transglutaminase in HAIRY-AND-ENHANCER- Cordell PA, Graham RM, Kearney preserved ejection fraction - coming O'Rourke MF, Nichols WW. S. Mechanosensitive channels in 2 mitigates transcriptional OF-SPLIT-7 in a family with MT, Jackson CL, Grant PJ. Effect of to terms with an oxymoron. Med J Microvascular angina or "vis a microbes. Annu Rev Microbiol. dyregulation in models of spondylocostal dysostosis. Eur J transglutaminase 2 (TG2) deficiency Aust. 2010; 192:4-5. tergo". J Am Coll Cardiol. 2010; 2010; 64:313-29. Huntington disease. EMBO Mol Hum Genet. 2010; 18:674-679. on atherosclerotic plaque stability 55: 611. in the apolipoprotein E deficient Vandenberg JI. Oxidative stress Med. 2010; 2:349-70. O'Rourke MF, Weber T, Adji A. Lai D, Liu X, Forrai A, Wolstein O, Squires JE, Preiss T. Function and mouse. Atherosclerosis 2010; fine-tunes the dance of hERG Aortic stiffness in hypertrophic Michalicek J, Ahmed I, Garratt AN, Medioni C, Bertrand N, Mesbah K, detection of 5-methylcytosine in 210:94-9. K+ channels. J Physiol. 2010; cardiomyopathy. J Am Coll Cardiol. Birchmeier C, Zhou M, Hartley L, Hudry B, Dupays L, Wolstein O, RNA. Epigenomics, 2010; 2:709- 588:2975. 2010; 55:504-505. Robb L, Feneley MP, Fatkin D, Washkowitz AJ, Papaioannou VE, 715. [Special report] Yuasa S, Onizuka T, Shimoji K, Mohun TJ, Harvey RP, Zaffran S. Ohno Y, Kageyama T, Yoon SH, Harvey RP. Neuregulin 1 sustains Suter CM, Martin DI. Reviews O'Rourke MF, Avolio A, Safar M, the gene regulatory network in Expression of Slit and Robo genes Egashira T, Seki T, Hashimoto H, Paramutation: the tip of an Nishiyama T, Kaneda R, Murata Nichols W. Changes in the central both trabecular and nontrabecular in the developing mouse heart. Dev Fatkin D, Otway R, Richmond Z. epigenetic iceberg? Trends Genet. M, Hattori F, Makino S, Sano M, arterial pressure pulse with aging. myocardium. Circ Res. 2010; Dyn. 2010; 239:3303-11. Genetics of dilated cardiomyopathy. 2010; 26:9-14. Ogawa S, Prall OW, Harvey RP, J Am Coll Cardiol. 2010; 55:2183. 107:715 -27. Heart Fail Clin. 2010; 6:129-140. O'Rourke MF, Safar ME, Dzau Fukuda K. Zac1 is an essential [author reply 2184]. Swarbrick A, Woods SL, Shaw A, V. The Cardiovascular Continuum transcription factor for cardiac Larance M, Rowland AF, Hoehn Balakrishnan A, Phua Y, Nguyen Harvey RP and Rosenthal N Otton J, Hayward C, Macdonald extended: Aging effects on the morphogenesis. Circ Res. 2010; K, Humphreys DT, Preiss T, A, Chanthery Y, Lim L, Ashton LJ, (Eds). Heart Development and PS. Gene-expression profiling after aorta and microvasculature. Vasc 106:1083-91. Guilhaus M, James DE. Global Judson RL, Huskey N, Blelloch R, Regeneration. Academic Press cardiac transplantation. N Engl J Med. 2010; 15:461-8. 2010, San Diego, CA. [ISBN 978-0- phosphoproteomics identifies Haber M, Norris MD, Lengyel P, Zhang S, Rattanatray L, Maclaughlin Med 2010; 363:1374. 12-3813329]. a major role for akt and 14-3-3 O'Tuathaigh CM, Harte M, O'Leary Hackett CS, Preiss T, Chetcuti A, SM, Cropley JE, Suter CM, in regulating Edc3. Mol Cell Sullivan CS, Marcusson EG, Weiss Towers KA, Bardsley KA, C, O'Sullivan GJ, Blau C, Lai Molloy L, Kleemann D, Walker O'Rourke MF, Adji A. Clinical Proteomics. 2010; 9:682-694. W, L'etoile N, Goga A. miR-380-5p Macdonald PS. Nebulised D, Harvey RP, Tighe O, Fagan SK, Muhlhausler BS, Morrison use of applanation tonometry: frusemide for the symptomatic AJ, Kerskens C, Reynolds GP, represses p53 to control cellular Lee LK, Stewart AG, Donohoe M, JL, McMillen IC. Periconceptional hope remains in Pandora's Box. J treatment of end-stage congestive Waddington JL. Schizophrenia- survival and is associated with undernutrition in normal and Bernal RA, Stock D. The structure Hypertens. 2010; 28:229-233. heart failure. Med J Aust. 2010; related endophenotypes in poor outcome in MYCN-amplified overweight ewes leads to increased of the peripheral stalk of Thermus 193:555. heterozygous neuregulin-1 neuroblastoma. Nat Med. 2010; adrenal growth and epigenetic Wouters MA, Fan SW, Haworth thermophilus H+-ATPase/synthase. 'knockout' mice. Eur J Neurosci. 16:1134 -1140. changes in adrenal IGF2/H19 NL. Disulfides as redox switches: O'Rourke MF, Safar ME, Roman Nat Struct Mol Biol. 2010 3:373-8. 2010; 31:349-58. gene in offspring. FASEB J. 2010; Tee AE, Marshall GM, Liu PY, Xu from molecular mechanisms to MJ. Letter by O'Rourke et Al 24:2772-82. functional significance. Antioxid regarding article, "Arterial stiffness Lee, LK, Ginsburg M, Crovace Posch MG, Gramlich M, Sunde N, Haber M, Norris MD, Iismaa C, Donohoe M, Stock D. The SE, Liu T. Opposing effects of two Redox Signal. 2010; 12:53-91. and cardiovascular events: M, Schmitt K, Richter S, Perrot A, Books & Book Chapters the framingham heart study". structure of the torque ring of the Panek AN, Al Khatib I, Nemer G, tissue transglutaminase protein flagellar motor and the molecular Letters to the Editor Circulation. 2010; 122:e512. Megarbane A, Dietz R, Stiller B, isoforms in neuroblastoma cell Beilharz TH, Humphreys DT, basis for rotational switching. [author reply 515] Berger F, Harvey RP, Ozcelik C. A differentiation. J Biol Chem. 2010; Preiss T. miRNA Effects on mRNA Nature 2010; 466:996-1000. 285:3561-7. Hirata K, Momomura S, O'Rourke gain-of-function TBX20 mutation Closed-Loop Formation During MF. Carotid flow augmentation as causes congenital atrial septal Vlachopoulos C, Aznaouridis Translation Initiation. In: Rhoads a risk for small vessel disease of defects, patent foramen ovale and K, O'Rourke MF, Safar ME, RE, ed. miRNA regulation of the the brain. Am J Hypertens. 2010; cardiac valve defects. J Med Genet. Baou K, Stefanadis C. Prediction translational machinery. 2009/10/21 23:932. [author reply 933]. 2010; 47:2350-235. of cardiovascular events and ed. Berlin, Heidelberg, New York, , Paris, Tokyo: Springer- Namasivayam M, Adji A, O'Rourke Romantsov T, Battle AR, Hendel all-cause mortality with central Verlag 2010:99-112. MF. Aortic augmentation index JL, Martinac B, Wood JM. Protein haemodynamics: a systematic and aging: mathematical resolution localization in Escherichia coli review and meta-analysis. Eur Harvey RP and Rosenthal N of a physiological dilemma. cells: comparison of cytoplasmic Heart J. 2010; 31:1865-71. (Eds). Heart Development and Hypertension. 2010; 56:e9-e10. membrane proteins ProP, LacY, Regeneration. Academic Press ProW, AqpZ, MscS, and MscL. J 2010, San Diego, CA. [ISBN 978-0- Bacteriol. 2010; 192:912-24. 12-3813329].

20. VCCRI ANNUAL REPORT 2010 VCCRI ANNUAL REPORT 2010 21. awards & achievements 2010 SYMPOSIA AND LECTURE SERIES

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Leah Cannon Dr James Chong Dr Lawrence Lee Juliane Heide Prof Roland Stocker Awarded a Travel grant Inaugural winner of the Awarded a full travel Awarded the Student’s International Barabara Ell Professor of Biochemistry to attend the ISHR XXth Fulbright New South grant by the Journal Poster Award Runner-up Symposium Seminar Series 2010 in Vascular Medicine World Congress, Kyoto, Wales Scholarship and of Cell Science at the prize for the Australian — — Pathology, Japan. Representing the UNSW University of Oxford. Physiological Society. School of Medical Sciences Faculty of Medicine This seminar series is Professor Bob To stay at the forefront of 3 minute thesis Li Sze Yeo Jennifer Cropley cutting-edge research, the named after Mrs Barbara “How heme oxygenase-1 protects Graham competition. against atherosclerosis and related Received a Postgraduate Awarded the VCCRI hosts an annual Ell, an avid supporter of the Elected as a foreign Research Student Poster Outstanding Postdoctoral disease” member of the Royal Li Sze Yeo international symposium, VCCRI, a Life Governor Prize at the UNSW Presentation Award for Prof Jane McCrohon Danish Academy of Awarded a Postgraduate Faculty of Medicine her talk at the inaugural incorporating the Princesses’ and a hard working member Sciences and Letters Research Student Research Day. NSW Epigenetics Lecture - named after the of both the Board and Cardiology St Vincent’s Hospital in their Natural Sciences Support Travel Grant, Alliance meeting. late Diana, Princess of Appeals Committee. “Assessing the myocardium using Class. UNSW. David Wang Wales and Crown Princess Each month the VCCRI invites Cardiac Magnetic Resonance Awarded a 2010 Dean's Paul Korner techniques—current and future David Ma Dr Lawrence Lee Mary of Denmark. a renowned Australian scientist List Award for his BSc Seminar Series directions” Awarded the David Awarded the St Vincent’s (Med) Hons work. Alistair Stewart Winner, In 2010, we were extremely to present a lecture as part of Walsh Memorial and Mater Health Liz Yeo and Chu-Kong fortunate to have Professor the Barbara Ell Seminar Series. Prof Frances Separovic Scholarship, Faculty Research Symposium David Ma Liew, Joint Runners Up Matthias Hentze, Associate Professor University of of Medicine, UNSW. Prof Marilyn Renfree Best Oral Presentation by Awarded the best ILP/ and the Paul and Staff Director of the European Melbourne a post-doc. Choice Winner David Laureate Professor Director Natalie Stunnell Honours Student Grand Molecular Biology Laboratory NMR and Structural Studies Rounds Presentation, Szekely. (EMBL) Germany, and a of ARC Centre of Excellence Will attend the 2010 Leah Cannon of Membrane Proteins St Vincent’s Clinical recipient of Germany’s for Kangaroo Genomics AALAS National “Resolving antimicrobial and Awarded the St School, UNSW Faculty highest research award, Ian Potter Chair of Zoology meeting. Vincent’s and Mater of Medicine. Degrees 2010 amyloid peptides in model The University of Melbourne — as our Princesses’ Lecturer, membranes” Professor Richard Health Research Symposium Best Oral Dr Lawrence Lee along with 10 other acclaimed “Life in the Pouch: Womb with Harvey Sharon Chih Prof Merlin Crossley Presentation by a Awarded the NARF keynote speakers from a view” Awarded the Lemberg student. (National Association Awarded a PhD, UNSW all corners of the globe Dean of the Faculty Medal and Oration, Prof Sam Berkovic of Research) Young and around Australia. of Science University of Australian Society Alastair Stewart Investigator Award. Andrew Jabbour Director Epilepsy Research for Biochemistry and Awarded the St Centre Molecular genetics Molecular Biology. Awarded a PhD, UNSW “The Klf Family of Mammalian Vincent’s and Mater Professor Jamie of epilepsy Vandenberg Transcription Factors” Health Research “Epilepsy, ion channels and the Dr Romaric Bouveret Mark Perrin Symposium Best Promoted to Conjoint heart—from family studies to A/Prof Sam El-Osta Awarded the Australian student poster Professor, UNSW Awarded a PhD, UNSW basic mechanisms“ Epigenetics in Human Health and New Zealand presentation. Faculty of Medicine. and Disease Laboratory Society of Cell and Elected President, Prof Lea Delbridge Developmental Biology Dr Guanglan Guo The Alfred Medical Research Australian Society for Head of Laboratory University of Postdoctoral Award. Biophysics. and Education Precinct (AMREP) Research has been Melbourne Cardiac Phenomics accepted for a poster “The Legacy of Hyperglycemic “Linking the developmental origins presentation at the David Szekely 01 Memory Associated with of genetic cardiac hypertrophy prestigious American Awarded the Australian Epigenetic Changes” Society of Human Society for Biophysics with perinatal autphagy excess” Genetics. Young Biophysicist award.

01 Professor Paul Korner & Liz Yeo 02 Professor Paul Korner & Chu-Kong Liew 02 22. VCCRI ANNUAL REPORT 2010 VCCRI ANNUAL REPORT 2010 23. SYMPOSIA AND LECTURE SERIES financials

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Alastair Stewart Income 2010 ($) 2009 ($) Paul Korner Gavin Chapman ‘Thermus thermophilus ‘Ligand-induced Grants 11,842,463 10,592,617 Seminar Series 2010 H+-ATPase/synthase’ trafficking of the — Alex James Notch1 receptor’ Fundraising 2,268,958 1,952,111 The Paul Korner Seminar Series is presented ‘Defining the role of Jessica Chaston Bequests 1,243,885 2,406,638 Notch4 in Angiogenesis’ ‘Structural investigation weekly, giving young scientists within the Other 1,929,797 2,268,181 Simon Keam of the TF55 Chaperonin VCCRI the opportunity to present some of from Sulfolobus ‘Piwi and piRNAs” A Total Income 17,285,103 17,219,547 the groundbreaking work they are carrying solfataraicus’ out within their individual research programs. role in somatic gene silencing?’ Inken Martin Jennifer Clancy Stefan Mann Dhakshinari Hulugalle ‘Do fish fibrillate? Expenses Modelling human cardiac ‘How microRNAs ‘In silico modeling ‘Computational arrhythmias in zebrafish’ Fundraising Events Expenses 638,907* 425,289 repress gene expression’ of cardiac disease investigation of the Jane Yu genotypes: how it adds association between Zinc Stuart Archer Salaries and related expenses 10,954,504 9,788,699 up to clinical insight sites and redox active ‘Investigating the ‘Simple or complex disulfides in proteins’ mechanisms of Research Consumables 1,989,251 1,946,559 mechanisms involved in Tram Doan eukaryotic translation induction of hypertrophy ‘Building Transcriptional Mardi Moradi Repairs and Maintenance 304,348 60,511 initiation’. in response to pressure Regulatory Networks for ‘Using advances overload’ Heart Development’ intercross line for high Chu-Kong Liew Other 2,189,478 3,049,821 Evgeny Petrov Mark Aplin resolution mapping ‘Towards the structure Total Expenses 16,076,488 15,270,879 of quantitative trait of a serpentine ‘Mechanosensitive ‘The role of loci affecting patent receptor: A game of ion channels as a Transglutaminase 2 foramen ovale’ snakes and ladders’ biophysical tool’ (TG2) in tissue injury Cheryl Li Surplus/(Deficit) before Depreciation 1,208,615 1,948,668 Amita Limaye and remodeling’ Orit Wolstein ‘Epigentic programming ‘Dosage of sensitivity ‘Role of SATB1L a Peter Riek Depreciation 1,570,528 1,331,146 in response to maternal of T-box transcription ‘chromatin organizer’ in ‘Is rhodopsin a suitable nutrition’ factors and congenital T cell differentiation and template for modeling heart defects’ development’ GPCRs?’ Leah Cannon Net Operating Surplus/(Deficit) (361,913) 617,522 Ming Li Chris Maloney ‘Mechanisms of Left Andy Ng Ventricular Hypertrophy ‘Structure and function of ‘Mast cell chymase limits ‘Epigenetic Origins of and Regression’ hERG N-terminal tail and the cardiac efficacy Complex Diseases’ Sara Ballouz PAS domain’ Non Operating Income/Expenses of Ang 1-converting Peter Tan enzyme inhibitor therapy’ ‘Computing, complexity David Szekely ‘Illuminating the Change in market value of investments (72,573) 11.430 and commonality: a ‘The Virtual Heart: Martin Oti mechanism of hERG holistic approach to Efficient and Interactive Depreciation on building 519,256 513,820 Evaluating disease gene channel activators’ understanding the Simulations of Cardiac candidacy using shared Arie Jacoby molecular mechanisms Electrical Function’. protein domains ‘Fish and SNPs: of complex diseases’ Naisana Asli Surplus/(Deficit) after non-operating items (808,596) 92,272 Duncan Sparrow Transgenic analysis of Liz Yeo ‘Cell Cycle Regulatory ‘Scoliotic spines and non-coding risk variants ‘Evaluation of mechanisms Networks in Adult holey hearts: Why acute in atrial fibrillation’ of contractile dysfunction Cardiac Stem Cells’ gestational hypoxia is Jason Liu in Lamin A/C-deficient bad news Carly Hynes ‘Gentrepid: A Webserver mice’ ‘Investigating the for candidate disease *Includes the cost of 2 cars purchased on behalf of the Freshest Group which they used to complexities of gene prediction’ fundraise for the VCCRI at their Annual Ball MicroRNA target interactions in 24. VCCRI ANNUAL REPORT 2010 Cardiac Biology’ VCCRI ANNUAL REPORT 2010 25. VCCRI HEALTH CHECK BOOTH

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In 2010 the VCCRI introduced a Health The Health Check Booth Service, available for Check Booth–its mission: Purpose hire during office hours from Monday to Friday, Cardiovascular Risk Factors — — provides: The nature of occupational illness and

workplace legal liability is changing. Health – confidential assessment testing Australian adults... conditions, stress, fatigue and the increased – information of immediate risk factors incidence of heart disease present new Have ONE or more Have HIGH BLOOD risk factors CHOLESTEROL To encourage employers to challenges to work health practices. – blood pressure measurements invest in the Heart Health of – blood sugar measurements The Victor Chang Health Check Booth has their employees and enhance been created to: – cholesterol measurements their well-being by providing a – Increase the understanding of Tests are conducted by a NSW Registered service to increase awareness of cardiovascular disease risk factors nurse in a private, branded and fully the modifiable risk factors for – Promote healthy lifestyles and reduce equipped booth. 90% 51% Cardiovascular Disease. obesity and other risk factors Tests take 10 minutes and results are – Enhance employee well-being and reduce provided directly to the participant. Have HIGH BLOOD PRESSURE HAVE DIABETES work related fatigue and stress – Invest in the heart health of employees Cardiovascular Disease – Raise awareness of the VCCRI and (CVD) Facts its research — The health and economic burden of Cardiovascular Disease exceeds that of any other disease-more than 3.7 million 30% 8% Australians have a long term cardiovascular condition. ARE NOT ARE OVERWEIGHT SUFFICIENTLY ACTIVE –  Heart disease is an Australia wide issue; it is our number 1 killer, responsible for 1 in 3 deaths or more than 48,000 people every year. –  CVD does not discriminate, it strikes young, old, male, female and directly 01 affects 2 in 3 families. 60% 54% 01 The Victor Chang Health Check –  Women are 4 times more likely to die of CVD DRINK AT HARMFUL SMOKING DAILY LEVELS Booth in action than cancer. It is Australia’s greatest yet least 02 The Victor Chang Health Check Booth & highlighted health concern. car, generously donated by Kia, & supported by Sydney Markets For further information about the Health Check Booth, please contact the Fund Development Office on (02) 9295 8600. 20% 10%

02 26. VCCRI ANNUAL REPORT 2010 VCCRI ANNUAL REPORT 2010 27. Research divisions

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Cardiac Physiology & Transplantation

Professor Michael Feneley Division Head Professor Anne Keogh Lab Head Professor Peter Macdonald Developmental Lab Head Biology A/Professor David Muller Lab Head Professor Richard Harvey Professor Michael O’Rourke Division Head Lab Head A/Professor Sally Dunwoodie Lab Head structural & Computational Biology

Dr. Daniela Stock Acting Division Head Dr. Merridee Wouters Group Leader

Molecular Cardiology & Biophysics

Professor Robert M. Graham AO Division Head Professor Boris Martinac Lab Head Professor Jamie Vandenberg Lab Head Molecular Genetics A/Professor Diane Fatkin A/Professor Thomas Preiss Lab Head Acting Division Head Dr Catherine Suter Lab Head

28. VCCRI ANNUAL REPORT 2010 VCCRI ANNUAL REPORT 2010 29. School science awards

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The Victor Chang Cardiac Research Institute School Science Award has been developed to foster and encourage an interest in science among secondary school students with a view to promoting science as a profession that provides a worthy and interesting career path.

Year 11 students from over 100 schools were “The Victor Chang School Science Awards awarded the Victor Chang School Science are about recognising our brightest young Award in 2010. From Cambelltown and minds for their commitment, passion, and Bankstown, Penrith, Blacktown, and new in achievement in science throughout the year. 2010, the Illawarra and South-East regions, students were presented the award at “Time and time again words such as special ceremonies throughout November. ‘motivated’, ‘enthusiastic’ and ‘dedicated’ have come up to describe these students. Awardees are nominated by their teachers These are all words that resonate strongly as demonstrating the highest achievement with the legacy of Dr Victor Chang himself, in scientific studies throughout the year. so it’s exciting to think that our next Dr With a dramatic decline in the number Chang could be right here amongst us.” of school students pursuing science as a tertiary education option, as well as pursuing Each recipient was presented with a framed science as a career path, the Awards were certificate, and given the opportunity to created to foster and encourage an interest attend a ‘hands-on’ work experience day in in science among secondary students. December with researchers at the VCCRI. Associate Professor Sally Dunwoodie, who attended the inaugural ceremony in the Illawarra Region, said the Awards give great hope for the future of Australian scientific research.

Time and time again words such as ‘motivated’, ‘enthusiastic’ and ‘dedicated’ have come up to describe these students. These are all words that resonate strongly with the legacy of Dr Victor Chang himself, so it’s exciting to think that our next Dr Chang could be right here amongst us.

01 Mrs Ann Chang, with recipients of the 2010 Victor Chang School Science Awards, Campbeltown/Bankstown region (right) 30. VCCRI ANNUAL REPORT 2010 VCCRI ANNUAL REPORT 2010 31. fundraising

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From Masterchefs getting ‘Mudcrabby’ at the Crabfest, to sporting 03 glory at the Golf Day and Sportman’s Lunch, to ‘Pulse’ the steer stealing the limelight at Sydney’s Royal Easter Show –The Chang fundraisers in 2010 were not only fun, but fabulous! 07 A special thank you to the wonderful members of the Victor Chang Appeals Committee, led enthusiastically by Louise Di Francesco and her predecessor John McGuigan, as Chairs in 2010.

The VCCRI is incredibly fortunate 04 08 to have the support and generosity of so many talented and dedicated supporters who work tirelessly to bring a calendar of fundraising 03 Pee Wee Wilson at the Victor Chang “Heart to Heart” Ball 04 Chefs Sean Connolly, Massimo Mele and Justin North with events to the Institute each year. MC Deborah Hutton at the Victor Chang ‘Crabfest’ 05 Chefs Christine Manfield, Massimo Mele and Martin Boetze getting ‘mudcrabby’ at the Victor Chang ‘Crabfest’ 06 The Delltones at the Victor Chang Annual Ball 07 Prime Minister Julia Gillard and partner Tim Mathieson at the Victor Chang Annual Ball 08 Guests at the Victor Chang ‘Heart to Heart’ Ball at the Sydney Convention Centre 09 Victor Chang Young Ambassador, Mr Mark Vincent, singing at the Victor Chang Ball

02 05

01 ‘Pulse’ the steer, with Murrumburrah High 06 School students & Mrs Ann Chang at the Sydney Royal Easter Show 02 Marcus Chang & group playing at the Victor Chang Golf Day at Terrey Hills Golf Course 01 09 32. VCCRI ANNUAL REPORT 2010 VCCRI ANNUAL REPORT 2010 33. fundraising Bequests

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Fundraising and Donations Today, bequests are becoming a more What is an executor? — important source of funding. However — small or generous a bequest may be, you An executor is someone you appoint Whether you belong to the corporate can be confident that it will assist the in your Will to see that your wishes and or private sector of our community the VCCRI in its quest to solve the mystery instructions are carried out after your VCCRI needs your support. of heart muscle disease. death. Many people choose a family If you would like to help the VCCRI win The following is a guideline as to how you member, a friend or a solicitor. its fight against heart disease there are can leave a legacy to the VCCRI. a number of ways in which you can help. How can I add to or change my 01 Attend/support VCCRI fundraisers What is my estate? existing Will? — — Make a donation to the VCCRI 02 01 A first step is to list all the possessions that If you have a limited change to make to 03 Leave a Bequest to the VCCRI you own. Your property (home, car, furniture, your Will – to add a bequest to a charity in your Will collections, etc.) savings, pension and annuities. for example, you don’t need to start all over All of these things make up your ‘Estate’. Instead of sending flowers, ask again. You can do so quickly and easily by 04 for donations to the VCCRI Then add up the estimated present value adding a codicil. A codicil is an instruction of these things you own. Subtract what which becomes part of the Will. Your solicitor 05 Instead of presents at a party, be you owe in the way of mortgage and debts. or trust officer should advise you. it a birthday, anniversary or some The net amount is your Estate. other celebration give a donation to the VCCRI in that person’s name What wording should a solicitor use? Who will benefit? — 06 Hold your own fundraising event — If you are considering a bequest to the VCCRI, the following forms of wording, Sponsor someone in a fun run This is up to you. You need to decide to depending on the type of bequest, are 07 or marathon whom you wish to leave your assets – your as follows: 02 family, and/or friends. These people are called the Beneficiaries of your Estate. “I give to The Victor Chang Cardiac Research You may also wish to leave money to a Institute, (ABN 61 068 363 235) 405 charity(s), once all your family and friends Liverpool Street, Darlinghurst, NSW, are cared for. We hope that you will consider The sum of $... or the VCCRI. A B ...% of my estate or Who should prepare my Will? C residue of my estate — (insert a, b or c) to be used for the purposes Your solicitor or a trustee company. This is the 01 Steve Quinn and the ‘Paceline’ crew, who raised over of research and I direct that the receipt of best way to make sure your Will is legal, and $45,000 in 2010 for the VCCRI, exhausted but smiling the Executive Director of the VCCRI shall on top of Lavers Hill, en route in October 2010. does what you want it to do. be sufficient discharge to my Executor(s).” 02 The Westfield Team, who cycled around Lake Taupo, The best way to ensure that your Will remains New Zealand, raised over $80,000 for the VCCRI in 2010. For further information you can telephone valid is to have it checked by your solicitor or The Fund Development Office on: trustee company every few years. Any change (02) 9295 8600 or 1300 VICTOR. in your personal circumstances may make a change in your Will necessary or desirable.

34. VCCRI ANNUAL REPORT 2010 VCCRI ANNUAL REPORT 2010 35. Designed and produced by Stop.Edit.

36 VCCRI ANNUAL REVIEW UPDATE 2010 Karolinksa Institute, Sweden

Institute of molecular biology, Germany

unIversity of amsterdam, netherlands university of geneva, switzerland

Oxford University, UK

warsaw university, poland

Pasteur Institute, France

Cardiff University, Wales

Victor chang cardiac research institute ABN 61 068 363 235 Lowy Packer Building 405 Liverpool Street Darlinghurst, NSW 2010 embl, italy T +61 2 9295 8600 www.victorchang.edu.au