08/09 VICTOR CHANG CARDIAC RESEARCH INSTITUTE REVIEW “BIOMEDICAL RESEARCH IS A GLOBAL ENTERPRISE INVOLVING A NETWORKK OF WORLDWIDELD COLLABORATIONS” HEART FACTS Mission statement & CONTENTS MARY AIKENHEAD MINISTRIES • • • • • • CHAIR: MR. RICHARD HARPHAM ST. VINCENT’S HEALTH The relief of pain and suffering and AUSTRALIA LTD CEO: DR. TRACEY Batten JOURNEY OF THE BLOOD CARDIOVASCULAR DISEASE PREVALEncE IN AUSTRALIANS the promotion of well-being, through an understanding of the fundamental ST. VINCENT'S & mechanisms of cardiovascular biology Mater HEALTH in health and disease. CEO: MR. STEVEN RUBIC VICTOR CHANG CARDIAC TO LUNGS AND BACK TO THE HEART THREE POINT SEVEN MILLION RESEARCH INSTITUTE Introduction — 00 Overview 00 Chairman'S Report VCCRI UNIVERSITY OF NSW 00 director'S Report VICE CHANCELLOR: PROFESSOR FRED HILMER, AO 00 Victor Chang organisational FIRST SINGLE LUNG TRANSPLANT FIRST BILATERAL LUNG TRANSPLANT HEART BEATS SEVENTY TIMES PER MINUTE PEOPLE WAITING FOR HEART TRANSPLANTS 00 Vale 00 The Institute structure 00 15 Years of Discovery BOARD CHAIRMAN MR. STEVEN LOWY, AM Board Committees — 00 Board Members COMMITTEES 00 Committees EXECUTIVE MANAGEMENT SCIENTIFIC ADVISORY MR. STEVEN LOWY Research programs COMMITEE FINANCE 1990 1992 3,000 — MR. JOHN KEAN 3,700,000 00 Cardiac Physiology and APPEALS Transplantation MR. JOHN MCGUIGAN NUMBER OF AUSTRALIAN WOMEN WHO DIED FROM CORONARY HEART DISEASE IN 2000 HEART FAILURE DEATHS HIGHER IN WOMEN HEART DISEASE DOESN'T DISCRIMINATE A HEART IS VIABLE OUTSIDE THE BODY HEART CONTRACTIONS PER DAY 00 Developmental Biology 00 Molecular Cardiology and Biophysics 00 Molecular Genetics EXECUTIVE DIRECTOR 00 Structural and PROFESSOR ROBERT STRIKES THE GRAHAM, AO Computational Biology AWARDS AND SEMINARS CHIEF Operating OFFICER — RESEARCH DIVISIONS YOUNG AND OLD 00 VCCRI Awardees UP 4HRS 100,000 00 Awards and Achievements 00 Seminar Series LIFE EXPECTANCY OF MEN FIRST ORGAN TO BEGIN FUNCTIONING PEOPLE WHO DIE OF (CVD) IN AUSTRALIA ML’S OF BLOOD PUMPED EACH BEAT 00 Symposium/Princesses Lecture 00 Publications 08/09 Administrative SUPPORT Administration Report — 00 Finance REPORT CORE FACILITIES ESSENTIAL SERVICES 00 Vccri Spotlight 00 Fundrasing and Functions 00 School Science Awards 76.6 HEART 1IN3 70-100 00 Limited Members 00 VCCRI Supporters 12,469 1_The VCCRI Annual Report 08/09 OVERVIEW • • • International — 8_Canada 13_Wales 16 8 17 – Howard Hughes Institute – Cardiff University 10 – Samuel Lunenfeld Research 13 14 20 22 Institute 14_Denmark OUR Institutions 12 – Royal Danish Academy 11 9_USA of Sciences & Letters 9 16 – Harvard Medical School, Boston 15_Japan 26 18 – Harvard Stem Cell Institute, Boston 15 – Cardiovascular Research Institute, – Osaka University 19 San Francisco – RIKEN, Saitama – University of San Francisco – Cincinnati Children’s Hospital 16_Sweden Medical Centre 25 – University of Virginia – Karolinksa Institute, Stockholm – University of Minnesota 24 – University of Wisconsin 17_UK – Mayo Clinic, Rochester – University of Oxford, England – Vanderbilt University, Tennessee – Royal Devon & Exeter Hospital, – University of Phoenix, Arizona The Worldwide Web Exeter – Case Western Reserve University, – University of Liverpool 23 Cleveland of Heart Research – Addenbrooke’s Hospital, Cambridge – Northwestern University, Chicago – University of Cambridge — – University of Chicago, Chicago – University of Oxford – Emory University School of – Imperial College of London More than ever before, science Medicine, Atlanta – Royal Brompton Hospital, London – Children’s Hospital Oakland progresses as an open-ended – University of Newcastle Upon Tyne Research Institute, California network of human activity. – Sanger Centre, Great Britain – Stanford University, California 5 – Royal College of Surgeons, Ireland The private curiosity, drive, insight 6 – UC San Diego, California 7 1 – Burnham Institute for Medical and even genius of individual 4 3 18_Korea 2 Research, La Jolla scientists are still at the core of – UMDNJ-New Jersey Medical – Yonsei University College this activity. However, the ability Virtually overnight, we moved from 21 School, Newark of Medicine, Seoul to communicate freely through an ability to analyse single genes at – Rochester University, NY – Cold Spring Harbour 19_China email and other electronic means, a time, extrapolating wildly about Laboratories, NY – Zensun Ltd, Shanghai and through the worldwide web to the behaviour of the whole cell, to The Victor Chang Cardiac Local – University of Illinois Urbana- one in which we can interrogate Research Institute is committed Champaign 20_ Switzerland access virtually all of the published — – UTMB, Galveston, Texas literature as well as websites hosting all of the 40,000 or so genes in to making important discoveries 1_ Sydney 4_Melbourne – University of Texas – University of Geneva the human genome in a single in cardiovascular biology and – Louisiana State University Health large data sets, has revolutionised 21_New Zealand medicine. Its scientists are – Victor Chang Cardiac – St. Vincent’s Institute Sciences Centre the way science is conducted. Ideas experiment. Robots have also allowed Research Institute – Walter & Eliza Hall Institute – Chori, USA us to do hundreds of thousands of very much embedded in the – Centenary Institute – Monash University – CSHL, USA – Starship Hospital, Auckland now circulate more freely instead of – University of Auckland manipulations that a singe researcher worldwide web of heart research. – Garvan Institute – Peter MacCallum Cancer Centre – University of Birmingham, Alabama being buried away in obscure books – St. Vincent’s Hospital – Baker IDI – University of Otago, Dunedin could not possibly contemplate. They collaborate widely with – Mesoblast Ltd 10_ Netherlands and journals, and can be seized upon, – Children’s Hospital & Medical 22_Poland Research Institute – University of Melbourne filtered and extended very rapidly The data sets we generate are huge, researchers internationally, and these – University of Amsterdam – Bosch Institute – Royal Melbourne Hospital – Warsaw University by others, much in the same way and there is a strong expectation in collaborations lead to important – Donate Life, Liverpool Hospital – Alfred Hospital – Academic Medical Centre, the community that these be made discoveries, as can be seen by the – Macquarie University Amsterdam 23_ Singapore as cultural ideas and trends pervade 5_Brisbane – VIB, Netherlands publicly available for other scientists high impact of our publications. – Millenium Institute, Westmead the community. Adding to this, the – Sydney Melanoma Unit – Nanyang University – Mater Medical Research Institute 1 1 _ F r a n c e to analyse. As a result, a new This impact is as much related to – University of Sydney technology of experimental science – IMB, University of Queensland 2 4 _ I n d i a – Prince of Wales Medical generation of scientists skilled how those discoveries pervade back – Queensland Institute for Medical – Pasteur Institute, Paris has changed dramatically. Research Institute Research – University of Nice, Sophia-Antipolis – Centre for Cellular & Molecular The scale of our endeavours, aided in information technology who help through the worldwide information – Children's Hospital Westmead – Griffith University Biology, Hyderabad by computers, is simply mind- us sift through these large data sets network and are used by others, – University of New South Wales 12_Germany for their hidden secrets, has emerged. as the discoveries themselves. – EngeneIC Ltd 6_Perth 25_Hong Kong boggling. Genes provide the heritable – BMI, Sydney – Institute of Molecular Biology, code for proteins and RNA, which are Because of the need for a greater These are exciting times, and the – WA Institute of Medical Research Hanover – University of Hong Kong 2_Wollongong – University of Western Australia – Karlsruhe Institute of Technology, range of expertise and technologies, brief profiles and stories provided 26_Italy the enzymes and structural elements – Curtin University Karlsruhe collaborations between laboratories in this VCCRI Annual Report speak – University of Wollongong – University of Cologne, Koeln that make up the cells of our bodies. – EMBL, Montorotondo and the sharing of reagents are now not only of the individuals and their 7_Adelaide – University of Heidelberg Accidental changes in genes or how 3_Canberra – EMBL vital parts of our work. Science is achievements, but also of the web- – Hanson Institute they are regulated cause disease, – Australian National University – Max Planck Institute – University of Adelaide conducted as a human network like organism of science and how it – John Curtin School of Medicine – Medical University, Berlin or contribute to the severity of – IVMS, Adelaide disease, including heart disease. spread across the globe. impacts our daily lives. – University of South Australia 2_The VCCRI Annual Report 08/09 3_The VCCRI Annual Report 08/09 Chairman’S Report • • • During our 15th year, the Institute was Ladies and gentlemen, each of the past Fundraising and functions Our inaugural Victor Chang Young Board and Appeals Committee able to reflect on how far it has come. 15 years has been marked by at least Without VCCRI friends and supporters Ambassador Award was presented to In these times of global financial It has established an international one major discovery in a wide-ranging our institute