Annual Report 2019 Annual Report
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Perillyl Alcohol Conjugate Downregulates O6-Methylguanin DNA Methltransferase Via Inducing Ubiquitination-De
Song et al. Cell Death and Disease (2018) 9:202 DOI 10.1038/s41419-017-0193-2 Cell Death & Disease ARTICLE Open Access Temozolomide–perillyl alcohol conjugate downregulates O6- methylguanin DNA methltransferase via inducing ubiquitination-dependent proteolysis in non-small cell lung cancer Xingguo Song1,LiXie1,2,MinghuiChang2,3,XinranGeng4,XingwuWang1,ThomasC.Chen5 and Xianrang Song 1,2 Abstract The DNA repair enzyme O6-methylguanin-DNA-methltransferase (MGMT) is able to remove products of alkylating agent such as O6-meG and emerges as a central determinant of cancer resistance to temozolomide (TMZ). Temozolomide–perillyl alcohol conjugate (TMZ–POH), a novel TMZ analog developed based on the conjugation of TMZ and POH, displayed strong anticancer potency in multiple cancer types, but seemed not to experience the chemoresistance even in cells with high MGMT expression unlike TMZ and other alkylating agents. In this study, we demonstrated TMZ–POH inhibited MGMT dependent on proteasomal pathway and this inhibition is a significant factor in its toxic effect in the non-small cell lung cancer (NSCLC) cells. 1234567890():,; 1234567890():,; Introduction such as O6-methyl-guanine (O6-meG), which trigger cell Nowadays, chemotherapy has been traditionally con- cycle-dependent DNA damage and cell death4. Although sidered as one of the standard treatment options for TMZ chemotherapy may enhance survival of cancer cancer patients, but the chemoresistance dramatically patients, intrinsic or acquired resistance to TMZ is also hinders its clinical application, especially for alkylating common and accounts for many treatment failures5, agents like temozolomide (TMZ)1. TMZ, an imidazote- because TMZ-induced DNA alkylation damage can be trazine derivative of the alkylating agent dacarbazine, was repaired by O6-methylguanin-DNA-methltransferase approved by the US FDA (Food and Drug Administration) (MGMT)6. -
WEIHAI CITY COMMERCIAL BANK CO., LTD.* 威海市商業銀行股份有限公司* (A Joint Stock Company Incorporated in the People’S Republic of China with Limited Liability) (Stock Code: 9677)
Hong Kong Exchanges and Clearing Limited and The Stock Exchange of Hong Kong Limited take no responsibility for the contents of this announcement, make no representation as to its accuracy or completeness and expressly disclaim any liability whatsoever for any loss howsoever arising from or in reliance upon the whole or any part of the contents of this announcement. WEIHAI CITY COMMERCIAL BANK CO., LTD.* 威海市商業銀行股份有限公司* (A joint stock company incorporated in the People’s Republic of China with limited liability) (Stock Code: 9677) ANNOUNCEMENT OF ANNUAL RESULTS FOR THE YEAR ENDED 31 DECEMBER 2020 The board of directors (the “Board”) of Weihai City Commercial Bank Co., Ltd.* (the “Bank”) hereby announces the audited annual results of the Bank and its subsidiary (the “Group”) for the year ended 31 December 2020. This announcement, containing the full text of the 2020 annual report of the Bank, complies with the relevant requirements of the Rules Governing the Listing of Securities on The Stock Exchange of Hong Kong Limited in relation to information to accompany preliminary announcement of annual results. The Group’s final results for the year ended 31 December 2020 have been reviewed by the audit committee of the Bank. This results announcement will be published on the website of The Stock Exchange of Hong Kong Limited (www.hkexnews.hk) and the Bank’s website (www.whccb.com). The Bank’s 2020 annual report will be despatched to the holders of H shares of the Bank and published on the websites of The Stock Exchange of Hong Kong Limited and the Bank in due course. -
Online Corruption-Reporting, Internet Censorship, and the Limits of Responsive Authoritarianism
Online Corruption-Reporting, Internet Censorship, and the Limits of Responsive Authoritarianism by Jack Hoskins BA, University of Victoria, 2015 A Thesis Submitted in Partial Fulfillment of the Requirements for the Degree of MASTER OF ARTS in the Department of History © Jack Hoskins, 2017 University of Victoria All rights reserved. This thesis may not be reproduced in whole or in part, by photocopy or other means, without the permission of the author. ii Supervisory Committee Online Corruption Reporting, Internet Censorship, and the Limits of Responsive Authoritarianism by Jack Hoskins BA, University of Victoria, 2015 Supervisory Committee Dr. Guoguang Wu (Department of History) Supervisor Dr. Colin Bennett (Department of Political Science) Outside Member iii Abstract This thesis traces the development of the Chinese government’s attempts to solicit corruption reports from citizens via online platforms such as websites and smartphone applications. It argues that this endeavour has proven largely unsuccessful, and what success it has enjoyed is not sustainable. The reason for this failure is that prospective complainants are offered little incentive to report corruption via official channels. Complaints on social media require less effort and are more likely to lead to investigations than complaints delivered straight to the government, though neither channel is particularly effective. The regime’s concern for social stability has led to widespread censorship of corruption discussion on social media, as well as a slew of laws and regulations banning the behaviour. Though it is difficult to predict what the long- term results of these policies will be, it seems likely that the regime’s ability to collect corruption data will remain limited. -
China Data Supplement
China Data Supplement October 2008 J People’s Republic of China J Hong Kong SAR J Macau SAR J Taiwan ISSN 0943-7533 China aktuell Data Supplement – PRC, Hong Kong SAR, Macau SAR, Taiwan 1 Contents The Main National Leadership of the PRC ......................................................................... 2 LIU Jen-Kai The Main Provincial Leadership of the PRC ..................................................................... 29 LIU Jen-Kai Data on Changes in PRC Main Leadership ...................................................................... 36 LIU Jen-Kai PRC Agreements with Foreign Countries ......................................................................... 42 LIU Jen-Kai PRC Laws and Regulations .............................................................................................. 45 LIU Jen-Kai Hong Kong SAR................................................................................................................ 54 LIU Jen-Kai Macau SAR....................................................................................................................... 61 LIU Jen-Kai Taiwan .............................................................................................................................. 66 LIU Jen-Kai ISSN 0943-7533 All information given here is derived from generally accessible sources. Publisher/Distributor: GIGA Institute of Asian Studies Rothenbaumchaussee 32 20148 Hamburg Germany Phone: +49 (0 40) 42 88 74-0 Fax: +49 (040) 4107945 2 October 2008 The Main National Leadership of the -
Annual Report 2019 X
CHAPTER I Definition 2 CHAPTER XI Corporate Governance Report 102 CHAPTER II Risk Warnings 5 I. Overview of Corporate Governance 102 CHAPTER III Company Profile 6 II. General Meeting 102 I. Profile 6 III. Performance of the Directors 104 II. History 9 IV. Work Performance of Board of Directors and 111 III. Staff Profile 11 Special Committees IV. Brief Introduction of the Organs and Branches 12 V. Chairman and General Manager 123 V. Basic Information about the Industry in Which the 16 VI. Securities Transactions by the Directors, Supervisors and 125 Company Operates Senior Management VI. Business Briefings of the Company 16 VII. Performance of Duties by Independent Non-executive 125 VII. Briefings of our Subsidiaries 17 Directors VIII. Honours Awarded to the Company During the 18 VIII. Supervision on Risk Management and Internal Control 125 Reporting Period System CHAPTER IV Financial Summary 20 IX. Other Relevant Matters 128 I. Major Accounting Data of the Group 20 CHAPTER XII Internal Control 133 II. Major Financial Indexes of the Group 20 I. Establishment of Internal Control Structure 133 III. Net Capital of the Company and Relevant Risk Control 21 II. Implementation and Operation of Internal Control System 133 Indicators III. Supervision and Inspection of Internal Control 133 IV. Financial Conditions of the Group of the Latest Five Years 22 IV. Conclusion of the Assessment of Internal Control 134 CHAPTER V Chairman Statement 23 CHAPTER XIII Independent Auditor’s Report 135 CHAPTER VI Management Discussion and Analysis 25 CHAPTER XIV Notes to the Consolidated Financial 140 I. Economic and Futures Market Analysis during the 25 Statements Reporting Period Consolidated Statements of Comprehensive Income 140 II. -
Resettlement Plan for Medium City Traffic Construction Project of Anhui Province
RP825 V1 World Bank Financed Project Public Disclosure Authorized Resettlement Plan for Medium City Traffic Construction Project of Anhui Province Public Disclosure Authorized (Summary Report) Public Disclosure Authorized Public Disclosure Authorized July 2009 Final Report of Resettlement Action Plan for World Bank Financed Medium City Traffic Construction Project of Anhui Province Terms and Definitions I. Displaced persons 1. Displaced persons (DPs) may be classified in one of the following three groups by eligibility for compensation: A. those who have formal legal rights to land (including customary and traditional rights recognized under the laws of the country); B. those who do not have formal legal rights to land at the time the census begins but have a claim to such land or assets—provided that such claims are recognized under the laws of the country or become recognized through a process identified in the resettlement plan; and C. those who have no recognizable legal right or claim to the land they are occupying. 2. Persons covered under para. 2(A) and (B) are provided compensation for the land they lose, and other assistance. Persons covered under para. 2(C) are provided resettlement assistance in lieu of compensation for the land they occupy, and other assistance, as necessary, to achieve the objectives set out in this policy, if they occupy the project area prior to a cut-off date1 established by the borrower and acceptable to the Bank. Persons who encroach on the area after the cut-off date are not entitled to compensation or any other form of resettlement assistance. All persons included in para. -
Brochure of the 11Th Pan-Beibu Gulf Economic Cooperation Forum
Contents I. Agenda...….…………………….......……………....….…………………02 II. List of Delegates......……………..………………....….……………………11 III. Registration ………………….......……………....….……………………33 IV. Catering ……………………………….......…...……...……………………34 V. Service Information…………….....…………………….......…...…..…35 Airport ..................................................................………........................…35 Hotel................................................................…………..............................35 Local Transport.........................…………………………............................35 Registration.................................................……………..……………........35 Pandemic Prevention and Control.................................................................36 Medical Services..........................................................................................36 Food Safety...................................................................................................36 Hotel Notes...................................................................................................36 VI. Security...........……………...….....................................................…...……37 VII. Notes...........……………...…..........................................................…...……38 VIII. Background Information...........……………...…..........................…...……39 Pan-Beibu Gulf Economic Cooperation Forum...........……………...….....39 China-ASEAN Port Cities Cooperation Network Work Conference...........42 Pan-Beibu Gulf Think Tank Summit.............................................…...……43 -
A Survey of Marine Coastal Litters Around Zhoushan Island, China and Their Impacts
Journal of Marine Science and Engineering Article A Survey of Marine Coastal Litters around Zhoushan Island, China and Their Impacts Xuehua Ma 1, Yi Zhou 1, Luyi Yang 1 and Jianfeng Tong 1,2,3,* 1 College of Marine Science, Shanghai Ocean University, Shanghai 201306, China; [email protected] (X.M.); [email protected] (Y.Z.); [email protected] (L.Y.) 2 National Engineering Research Center for Oceanic Fisheries, Shanghai 201306, China 3 Experimental Teaching Demonstration Center for Marine Science and Technology, Shanghai Ocean University, Shanghai 201306, China * Correspondence: [email protected] Abstract: Rapid development of the economy increased marine litter around Zhoushan Island. Social- ecological scenario studies can help to develop strategies to adapt to such change. To investigate the present situation of marine litter pollution, a stratified random sampling (StRS) method was applied to survey the distribution of marine coastal litters around Zhoushan Island. A univariate analysis of variance was conducted to access the amount of litter in different landforms that include mudflats, artificial and rocky beaches. In addition, two questionnaires were designed for local fishermen and tourists to provide social scenarios. The results showed that the distribution of litter in different landforms was significantly different, while the distribution of litter in different sampling points had no significant difference. The StRS survey showed to be a valuable method for giving a relative overview of beach litter around Zhoushan Island with less effort in a future survey. The questionnaire feedbacks helped to understand the source of marine litter and showed the impact on the local environment and economy. -
Inside Information Bankruptcy and Liquidation of a Subsidiary of the Company
Hong Kong Exchanges and Clearing Limited and The Stock Exchange of Hong Kong Limited take no responsibility for the contents of this announcement, make no representation as to its accuracy or completeness and expressly disclaim any liability whatsoever for any loss howsoever arising from or in reliance upon the whole or any part of the contents of this announcement. (a sino-foreign joint stock limited company incorporated in the People’s Republic of China) (Stock Code: 00991) INSIDE INFORMATION BANKRUPTCY AND LIQUIDATION OF A SUBSIDIARY OF THE COMPANY This announcement is made by Datang International Power Generation Co., Ltd. (the “Company”) pursuant to Part XIVA of the Securities and Futures Ordinance (Cap. 571, Laws of Hong Kong) and Rules 13.09(2)(a) and 13.10B of the Rules Governing the Listing of Securities on The Stock Exchange of Hong Kong Limited(the “Hong Kong Listing Rules”). This announcement is also made by the Company pursuant to Rules 13.25(1), 13.51B(2) and 13.51(2)(l) of the Hong Kong Listing Rules. The board of directors of the Company (the “Board”) announced that Datang Anqing Biomass Power Generation Co., Ltd. (“Anqing Company”), a holding subsidiary of the Company, received the Civil Ruling from the People’s Court of Daguan District, Anqing City, Anhui Province ((2021) Wan 0803 Po Shen No. 1) recently. 1. OVERVIEW OF THE BANKRUPTCY AND LIQUIDATION Anqing Company applied to the People’s Court of Daguan District, Anqing City, Anhui Province for the bankruptcy and liquidation on the ground that it was unable to settle its due debts and its assets were insufficient to pay off all its debts. -
New Oriental Education & Technology Group Inc
Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F (Mark One) ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(B) OR 12(G) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended May 31, 2011. OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☐ SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of event requiring this shell company report For the transition period from to Commission file number: 001-32993 NEW ORIENTAL EDUCATION & TECHNOLOGY GROUP INC. (Exact name of Registrant as specified in its charter) N/A (Translation of Registrant’s name into English) Cayman Islands (Jurisdiction of incorporation or organization) No. 6 Hai Dian Zhong Street Haidian District, Beijing 100080 The People’s Republic of China (Address of principal executive offices) Louis T. Hsieh, President and Chief Financial Officer Tel: +(86 10) 6260-5566 E-mail: [email protected] Fax: +(86 10) 6260-5511 No. 6 Hai Dian Zhong Street Haidian District, Beijing 100080 The People’s Republic of China (Name, Telephone, E-mail and/or Facsimile number and Address of Company Contact Person) Securities registered or to be registered pursuant to Section 12(b) of the Act: Title of Each Class Name of Exchange on Which Registered American depositary shares, each representing one New York Stock Exchange common share* Common shares, par value US$0.01 per share New York Stock Exchange** * Effective August 18, 2011, the ratio of ADSs to our common shares was changed from one ADS representing four common shares to one ADS representing one common share. -
Qinghai WLAN Area 1/13
Qinghai WLAN area NO. SSID Location_Name Location_Type Location_Address City Province 1 ChinaNet Quality Supervision Mansion Business Building No.31 Xiguan Street Xining City Qinghai Province No.160 Yellow River Road 2 ChinaNet Victory Hotel Conference Center Convention Center Xining City Qinghai Province 3 ChinaNet Shangpin Space Recreation Bar No.16-36 Xiguan Street Xining City Qinghai Province 4 ChinaNet Business Building No.372 Qilian Road Xining City Qinghai Province Salt Mansion 5 ChinaNet Yatai Trade City Large Shopping Mall Dongguan Street Xining City Qinghai Province 6 ChinaNet Gome Large Shopping Mall No.72 Dongguan Street Xining City Qinghai Province 7 ChinaNet West Airport Office Building Business Building No.32 Bayi Road Xining City Qinghai Province Government Agencies 8 ChinaNet Chengdong District Government Xining City Qinghai Province and Other Institutions Delingha Road 9 ChinaNet Junjiao Mansion Business Building Xining City Qinghai Province Bayi Road Government Agencies 10 ChinaNet Higher Procuratortate Office Building Xining City Qinghai Province and Other Institutions Wusi West Road 11 ChinaNet Zijin Garden Business Building No.41, Wusi West Road Xining City Qinghai Province 12 ChinaNet Qingbai Shopping Mall Large Shopping Mall Xining City Qinghai Province No.39, Wusi Avenue 13 ChinaNet CYTS Mansion Business Building No.55-1 Shengli Road Xining City Qinghai Province 14 ChinaNet Chenxiong Mansion Business Building No.15 Shengli Road Xining City Qinghai Province 15 ChinaNet Platform Bridge Shoes City Large Shopping -
The World Bank Financial Assistance Project
SFG2699 REV Public Disclosure Authorized The World Bank Financial Assistance Project Jingxi Farm Produce Distribution System Development Project Environmental Management Plan (EMP) Public Disclosure Authorized (Draft for Approval) Public Disclosure Authorized Construction Unit: Jiangxi Provincial Rural Social Affairs Development Bureau under Agricultural Department of Jiangxi Province Evaluation Institute: NO. 270 Research Institute of Jiangxi Nuclear Industry November, 2016 Public Disclosure Authorized I World Bank Loans----Jingxi Farm Produce Distribution System Development Project Responsibility list Project Name: The World Bank Financial Assistance Project---- Jiangxi Agricultural Products Distribution System Project Client: Jiangxi Provincial Rural Social Affairs Bureau under griculture Department of Jiangxi Province Project Category: Environmental Impact Statement (EIA category B) Legal Representative: Que Zushuang Institution in Charge of Compilation: NO. 270 Research Institute of Nuclear Industry Technical Review: Chen Zhiping Project Leader: Wan Fen Situation of evaluation personnel Registration Professional Professional Name (Registration Chapter Signature Certificate NO. Category Certificate) NO. Wan Chapter 1, 0011309 B231601707 Transportation Fen 3 and 4 Zheng Chapter 2 00013735 B23160071000 Social region Han and 5 Agriculture, Qiu forestry and Chapter 6 00015384 B231601505 Heng water and 9 conservancy Zhu Chapter 7 00016190 B23160091600 Transportation Fangxu and 8 Li Yuan 00015378 B231601407 Transportation Chapter 10 II