DOCSLIB.ORG

Original Article Effects of Butylphthalide Combined With

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Original Article Effects of Butylphthalide Combined With Int J Clin Exp Med 2020;13(10):7773-7779 www.ijcem.com /ISSN:1940-5901/IJCEM0112554 Original Article Effects of butylphthalide combined with Naofukang on cognitive function and the expression of serum neurotrophic factor in patients with vascular dementia Yonghua Chen1*, Jinlong Zhao2*, Hao Wu3, Xiaoyi Li4, Mingjun Zhang5 1Department of Psychiatry, Zhoushan Second People’s Hospital, Zhoushan 316000, Zhejiang, China; 2Depart- ment of Psychology, Armed Police Corps Hospital, Jiaxing 314000, Zhejiang, China; 3Department of Psychiatry, Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang, China; 4Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou 310012, Zhejiang, China; 5Depart- ment of General Medicine, Zhoushan Second People’s Hospital, Zhoushan 316000, Zhejiang, China. *Co-first authors. Received April 14, 2020; Accepted June 2, 2020; Epub October 15, 2020; Published October 30, 2020 Abstract: Objective: This study aimd to determine the effect of butylphthalide combined with Naofukang on cogni- tive function and serum neurotrophic factor level in patients with vascular dementia. Methods: A total of 172 pa- tients with vascular dementia were randomly enrolled and equally divided into an observation group and a control group. Patients in the control group received Naofukang orally besides routine treatment, while the observation group was treated with Butylphthalide Soft Capsules in addition to Naofukang for 12 weeks. Simple Mental State Examination (MMSE) and Clinical Dementia Degree Scale (CDR) were used to assess cognitive function. Activity of Daily Life Scale (ADL) and Barthel Index were used to evaluate the self-care ability of patients. Adverse drug reac- tions were recorded while serum neurotrophic factor (BDNF) level was detected by ELISA. Results: The therapeutic effect of the observation group (86.05%) was significantly higher than that of the control group (70.93%) (P<0.05). MMSE and CDR scores showed no significant difference between two groups before treatment (P>0.05). After treatment, the MMSE score in observation group was significantly increased and the CDR score was statistically reduced compared to those in the control group (P<0.05). In addition, MMSE scores were significantly elevated and CDR scores were markedly decreased after treatment (P<0.05). Butylphthalide combined with Naofukang sig- nificantly improved the Barthel index score, whereas it markedly decreased the ADL score compared to single use of Naofukang (P<0.05). After treatment, serum BDNF level was significantly increased in both groups and it was further up regulated in the observation group compared to control group (P<0.05). Adverse reaction rates showed no significant difference between the two groups (P>0.05). Conclusion: Butylphthalide combined with Naofukang can improve cognitive function and patients’ self-care ability, which maybe implicated to the changes in BDNF levels. Keywords: Butylphthalide, Naofukang, vascular dementia, cognitive function, serum neurotrophic factor Introduction tant types of Alzheimer’s related diseases. In recent years, as the aging population increas- Vascular dementia (VaD) is caused by brain es, the prevalence of VaD is rising rapidly. The damage owing to cerebral hypoperfusion and incidence of VaD in males is clearly higher lesions such as multiple stroke or chronic ce- than that in females [5]. At present, the treat- rebral ischemia [1-3]. Cognitive dysfunction is ment of VaD mostly depends on drug inter- an important clinical symptom of VaD patients. vention, but the clinical effects vary in multi- The patients frequently present with dysfunc- ple types of medicine. Therefore, how to effec- tion of language, memory, orientation, beha- tively improve the cognitive impairment and vior and so on, which seriously affects cogni- patient’s quality life remains to be settled [6]. tive function, social activities and quality of life. The disease even causes great psychologi- Butylphthalide is a new kind of lipid-soluble cal pressure and economic burden to patients drug, which can directly exert anti-cerebral is- and their families [4]. VaD is one of the impor- chemia functions and protect neurons against Effects of butylphthalide in patients with vascular dementia injury through the blood-brain barrier [7, 8]. equally assigned into a control group and an Therefore, in 2002, butylphthalide was official- observation group by a double blind method. ly approved by China’s Food and Drug Admi- nistration as a new drug for the treatment of Therapeutic methods acute ischemic stroke. Many animal experi- ments and pharmacodynamic studies have Patients from both groups received basic confirmed that butylphthalide has protective treatment such as routine control of blood effects on nerve cells, and its structure as well pressure, blood sugar, blood lipids, anticoagu- lation, regulation of cerebral circulation and as clinical safety has been determined [9, 10]. brain metabolism. The control group was given Naofukang, also known as piracetam, is a cy- Naofukang (piracetam tablet, Tianjin Jinshi clic derivative of alpha-aminolevulinic acid. It Pharmaceutical Co., Ltd., the Chinese medi- has the function of activating, protecting and cine standard H12020667, specifications: 0.4 repairing neuronss and can be used for the g*100 tablets), orally 0.8 g/3 times/d, along treatment of memory impairment and cognitive with the routine treatment. The observation dysfunction caused by cerebrovascular diseas- group received Butylphthalide Soft Capsules es, brain trauma and various toxic encephalop- (Enbipu, produced by Enbipu Pharmaceuti- athy [11, 12]. This study explored the thera- cal Co., Ltd. of Stone Pharmaceutical Group, peutic effect of Butylphthalide combined with the Chinese medicine standard H20050299, Naofukang on VaD and analyzed their effects specifications: 0.1 g*24 capsules) orally 0.2 on brain-derived neurotrophic factor (BDNF), g/3 times/d for 12 weeks. which is expected to provide ideas and evi- dence for the clinical treatment of VaD. Observation Indicators Materials and methods Cognitive function was assessed by MMSE and CDR: Among them, the MMSE scale includes General information 30 questions with a total score of 30. If the score is lower than 23, a cognitive impairment A total of 172 patients with VaD from June is implicated. The score is negatively corre- 2017 to June 2018 were enrolled. The diagno- lated to the severity of cognitive impairment. sis was performed according to the diagnostic CDR scale mainly includes memory, orienta- criteria of VaD based on American Psychiatric tion, judgment and question-solving ability, Association’s Diagnostic and Statistical Man- work and social communication ability, family ual for Psychiatry (DSMIV) 5th edition. life and personal hobbies, and self-care ability for an independent life. Each aspect is as- Inclusion criteria [13]: 1) patients diagnosed sessed by five grades from harmlessness to with ischemic stroke previously by brain CT or/ severe damage. However, the scores of each or MRI; 2) patients with dementia occurring aspect are not superimposed. Instead, the six within 3 months after stroke and lasting for aspects are assessed as a total score. The more than 6 months; 3) Hachonski ischemic comprehensive results are expressed as 0, score ≥7; 4) MMSE score was between 12-23 0.5, 1, 2 and 3 points. A higher score indicates points. Exclusion criteria: 1) patients with se- more serious cognitive dysfunction. vere heart, liver, kidney dysfunction or hema- tological diseases, malignant tumors and ca- The ADL and Barthel index were used to asse- chexia; 2) patients with other nervous system ss the self-care ability of the patients: Among diseases or psychiatric diseases, depression, them, there are 14 items in the ADL scale, etc.; 3) patients with dementia before stroke; 4) including self-care, exercise, housework and patients who have incomplete clinical data, or communication. The total score ranges from took drugs which affected cognitive function 14 to 56, and the lowest is 14, which indica- recently, or stopped treatment due to intoler- tes completely normal. When the ADL score is ance or severe adverse reactions of drugs in more than 14, it denotes that there are differ- this study. The study was approved by the Eth- ent degrees of functional decline. The critical ics Committee of Zhoushan Second People’s value is 20. A high score suggests poor prog- Hospital. All participants were aware of the nosis. The Barthel index has 10 items, includ- contents of this study and signed the informed ing eating, bathing, decorating, dressing, defe- consent. The 172 patients were randomly and cation control, toilet use, bed and chair trans- 7774 Int J Clin Exp Med 2020;13(10):7773-7779 Effects of butylphthalide in patients with vascular dementia Statistical analysis The data were input into SPSS 15.0 for result analysis and statistical processing. The count- ing data were displayed as mean ± standard deviation. The comparison between the two groups and the comparison before and after treatment were analyzed by t-test. The mea- surement data were displayed as percentage or number of cases, and the comparison bet- ween the two groups was analyzed by chi- square test. P<0.05 indicates a significant difference. Result Basic characteristics of participants The control group consisted of 44 males and 42 females, aged 55-74 years (average age: 62.58+4.73), and disease course ranged from 7 to 23 months (average: 5.36+4.08 mon- ths). The observation group included 43 males Figure 1. Comparison of efficiency. and 43 females, aged 57-75 years (average: 63.42±4.88) with a course of disease of 7-25 fer, walking and stairs up and down. A full score months (average: 16.14±4.72 months). Gene- of 100 means that patients have good activi- ral data were comparable and no significant ties of daily life, while a score below 60 indi- difference was found between the two groups cates that patients have moderate to severe (P>0.05). dysfunction of activities and need care from others in daily life.
Load more

Recommended publications
  • A Survey of Marine Coastal Litters Around Zhoushan Island, China and Their Impacts
    Journal of Marine Science and Engineering Article A Survey of Marine Coastal Litters around Zhoushan Island, China and Their Impacts Xuehua Ma 1, Yi Zhou 1, Luyi Yang 1 and Jianfeng Tong 1,2,3,* 1 College of Marine Science, Shanghai Ocean University, Shanghai 201306, China; [email protected] (X.M.); [email protected] (Y.Z.); [email protected] (L.Y.) 2 National Engineering Research Center for Oceanic Fisheries, Shanghai 201306, China 3 Experimental Teaching Demonstration Center for Marine Science and Technology, Shanghai Ocean University, Shanghai 201306, China * Correspondence: [email protected] Abstract: Rapid development of the economy increased marine litter around Zhoushan Island. Social- ecological scenario studies can help to develop strategies to adapt to such change. To investigate the present situation of marine litter pollution, a stratified random sampling (StRS) method was applied to survey the distribution of marine coastal litters around Zhoushan Island. A univariate analysis of variance was conducted to access the amount of litter in different landforms that include mudflats, artificial and rocky beaches. In addition, two questionnaires were designed for local fishermen and tourists to provide social scenarios. The results showed that the distribution of litter in different landforms was significantly different, while the distribution of litter in different sampling points had no significant difference. The StRS survey showed to be a valuable method for giving a relative overview of beach litter around Zhoushan Island with less effort in a future survey. The questionnaire feedbacks helped to understand the source of marine litter and showed the impact on the local environment and economy.
    [Show full text]
  • Identifying the Financing Pattern Problems
    日本建築学会計画系論文集 第84巻 第756号，323-331， 2019年2月 【カテゴリーⅠ】 J. Archit. Plann., AIJ, Vol. 84 No. 756, 323-331, Feb., 2019 DOI http://doi.org/10.3130/aija.84.323 IDENTIFYINGIDENTIFYING THE THE FINANCING FINANCING PATTERN PATTERN PROBLEMS PROBLEMS OF DILAPIDATED OF DILAPIDATED URBAN URBANHOUSING HOUSING RENEWAL RENEWAL SYSTEM SYSTEM IN ZHEJIANG, IN ZHEJIANG, CHINA: CHINA: CASECASE STUDY STUDY OF OF JINSHOUJINSHOU PROJECTPROJECT IN IN ZHOUSHAN ZHOUSHAN 中国浙江の危房改造システムの資金面の問題点：舟山の「金寿新村」プロジェクトを対象に୰ᅜύỤࡢ༴ᡣᨵ㐀ࢩࢫࢸ࣒ࡢ㈨㔠㠃ࡢၥ㢟Ⅼ ⯚ᒣࡢࠕ㔠ᑑ᪂ᮧࠖࣉࣟࢪ࢙ࢡࢺࢆᑐ㇟࡟ ＊1 ＊2 LiLi GUAN GUAN* and and Takashi Takashi ARIGA ARIGA** ⟶ࠉࠉ⌮㸪᭷㈡ࠉ㝯管 理，有 賀 隆 A dualistic system of private urban housing renewal consisting of marketized “Old City Renewal” and government voluntary “Dilapidated Urban Housing Renewal” has been established in China since 2015. Focusing on the latter '8+5PRGHWKLVVWXG\DLPVWRLGHQWLI\LWVSUREOHPVIURPWKHSHUVSHFWLYHRIÀQDQFLQJSDWWHUQ-LQVKRX3URMHFWLQ =KRXVKDQLVVHOHFWHGDVDUHSUHVHQWDWLYHFDVHWRFODULI\WKH'8+5PRGHLQ=KHMLDQJ3URYLQFH7KURXJKDQDO\]LQJWKH VWDWLVWLFVRISURMHFWIXQGLQJWKLVSDSHUDUJXHVWKDWWKH'8+5PRGHFRPSOHWHO\UHOLHVRQSXEOLFIXQGLQJDQGLVKDUGWR tackle the increasing number of dilapidated housing. Keywords: Dilapidated Urban Housing Renewal, Old City Renovation, Financing pattern, China ༴ᡣᨵ㐀㸪ᪧᇛᨵ㐀㸪㈨㔠ࡢὶࢀ㸪୰ᅜ 1. Introduction structure has been seriously damaged or the load-bearing 1.1. Research background component is in danger and may at any time lose the stability Evolution of Chinese urban housing system and load-bearing capacity.*4) Recent years, frequent collapse The Chinese social
    [Show full text]
  • Results Announcement for the Year Ended December 31, 2020
    (GDR under the symbol "HTSC") RESULTS ANNOUNCEMENT FOR THE YEAR ENDED DECEMBER 31, 2020 The Board of Huatai Securities Co., Ltd. (the "Company") hereby announces the audited results of the Company and its subsidiaries for the year ended December 31, 2020. This announcement contains the full text of the annual results announcement of the Company for 2020. PUBLICATION OF THE ANNUAL RESULTS ANNOUNCEMENT AND THE ANNUAL REPORT This results announcement of the Company will be available on the website of London Stock Exchange (www.londonstockexchange.com), the website of National Storage Mechanism (data.fca.org.uk/#/nsm/nationalstoragemechanism), and the website of the Company (www.htsc.com.cn), respectively. The annual report of the Company for 2020 will be available on the website of London Stock Exchange (www.londonstockexchange.com), the website of the National Storage Mechanism (data.fca.org.uk/#/nsm/nationalstoragemechanism) and the website of the Company in due course on or before April 30, 2021. DEFINITIONS Unless the context otherwise requires, capitalized terms used in this announcement shall have the same meanings as those defined in the section headed “Definitions” in the annual report of the Company for 2020 as set out in this announcement. By order of the Board Zhang Hui Joint Company Secretary Jiangsu, the PRC, March 23, 2021 CONTENTS Important Notice ........................................................... 3 Definitions ............................................................... 6 CEO’s Letter .............................................................. 11 Company Profile ........................................................... 15 Summary of the Company’s Business ........................................... 27 Management Discussion and Analysis and Report of the Board ....................... 40 Major Events.............................................................. 112 Changes in Ordinary Shares and Shareholders .................................... 149 Directors, Supervisors, Senior Management and Staff..............................
    [Show full text]
  • Spatial Distribution Pattern of Minshuku in the Urban Agglomeration of Yangtze River Delta
    The Frontiers of Society, Science and Technology ISSN 2616-7433 Vol. 3, Issue 1: 23-35, DOI: 10.25236/FSST.2021.030106 Spatial Distribution Pattern of Minshuku in the Urban Agglomeration of Yangtze River Delta Yuxin Chen, Yuegang Chen Shanghai University, Shanghai 200444, China Abstract: The city cluster in Yangtze River Delta is the core area of China's modernization and economic development. The industry of Bed and Breakfast (B&B) in this area is relatively developed, and the distribution and spatial pattern of Minshuku will also get much attention. Earlier literature tried more to explore the influence of individual characteristics of Minshuku (such as the design style of Minshuku, etc.) on Minshuku. However, the development of Minshuku has a cluster effect, and the distribution of domestic B&Bs is very unbalanced. Analyzing the differences in the distribution of Minshuku and their causes can help the development of the backward areas and maintain the advantages of the developed areas in the industry of Minshuku. This article finds that the distribution of Minshuku is clustered in certain areas by presenting the overall spatial distribution of Minshuku and cultural attractions in Yangtze River Delta and the respective distribution of 27 cities. For example, Minshuku in the central and eastern parts of Yangtze River Delta are more concentrated, so are the scenic spots in these areas. There are also several concentrated Minshuku areas in other parts of Yangtze River Delta, but the number is significantly less than that of the central and eastern regions. Keywords: Minshuku, Yangtze River Delta, Spatial distribution, Concentrated distribution 1.
    [Show full text]
  • SUPPLIER LIST OCTOBER 2019 Cotton on Group - Supplier List 2
    SUPPLIER LIST OCTOBER 2019 Cotton On Group - Supplier List _2 REGION SUPPLIER NAME FACTORY NAME SUPPLIER ADDRESS PRODUCT TOTAL % OF % OF % OF TYPE WORKERS FEMALE MIGRANT TEMP WORKERS WORKERS WORKERS BANGLADESH APTECH DESIGN LTD DESIGNER FASHION LTD GOHAILBARI SHIMULIA APPAREL 3422 72% 0% 0% SAVAR DHAKA BANGLADESH APTECH DESIGN LTD Y-FRONTS ACCESSORIES (NEW HOUSE 24, WARD # 01, ARSHINAGOR MAIN ROAD APPAREL 24 0% 0% 0% LOCATION) ARSHINAGOR, KERANIGONJ DHAKA BANGLADESH BELAMY TEXTILES LTD BELAMY TEXTILES LTD KHOWAZ NAGAR, AZIMPARA APPAREL KARNAFULLY CHITTAGONG BANGLADESH BIG BOSS CORPORATION LTD (of aptech BIG BOSS CORPORATION LTD (NEW) APTECH INDUSTRIAL PARK APPAREL group) 30 SHARABO,KASIMPUR GAZIPUR BANGLADESH CLASSIC FASHIONS FOUR DESIGN PVT LTD (NEW) PLOT NO. B-201, 202, BSCIC HOSIERY I/E APPAREL 305 64% 0% 0% SHASONGAON, ENAYETNAGAR, FATULLAH NARAYANGANJ BANGLADESH CLASSIC FASHIONS FOUR DESIGN PVT LTD (TEMPORARY) PLOT NO. B327/328, BSCIC HOSIERY I/E APPAREL 380 60% 0% 0% SHASONGAON, ENAYETNAGAR, FATULLAH NARAYANGANJ BANGLADESH IMPRESS NEWTEX COMPOSITE TEXTILES B2B EXCELLANCE LTD MIRZAPUR PURBAPARA, APPAREL 1355 76% 0% 0% LTD 8 NO. MIRZAPUR MOUZA, GAZIPUR SADAR,GAZIPUR BANGLADESH IMPRESS NEWTEX COMPOSITE TEXTILES IMPRESS NEWTEX COMPOSITE TEXTILES GORAI INDUSTRIAL AREA APPAREL 2124 56% 0% 0% LTD LTD MIRZAPUR TANGAIL BANGLADESH IRIS FABRICS LIMITED IRIS FABRICS LIMITED ZIRANIBAZAR APPAREL 2984 47% 0% 0% KASHIMPUT, JOYDEVPUR GAZIPUR BANGLADESH JERICHO IMEX JERICHO IMEX LTD MONTREE BARI ROAD APPAREL 700 62% 0% 0% SOUTH SHANLA, SHANLA BAZAR
    [Show full text]
  • SUPPLIER LIST AUGUST 2019 Cotton on Group - Supplier List 2
    SUPPLIER LIST AUGUST 2019 Cotton On Group - Supplier List _2 COUNTRY FACTORY NAME SUPPLIER ADDRESS STAGE TOTAL % OF % OF % OF TEMP WORKERS FEMALE MIGRANT WORKER WORKERS WORKER CHINA NINGBO FORTUNE INTERNATIONAL TRADE CO LTD RM 805-8078 728 LANE SONGJIANG EAST ROAD SUP YINZHOU NINGBO, ZHEJIANG CHINA NINGBO QIANZHEN CLOTHES CO LTD OUCHI VILLAGE CMT 104 64% 75% 6% GULIN TOWN, HAISHU DISTRICT NINGBO, ZHEJIANG CHINA XIANGSHAN YUFA KNITTING LTD NO.35 ZHENYIN RD, JUEXI STREET CMT 57 60% 88% 12% XIANGSHAN COUNTY NINGBO CITY, ZHEJIANG CHINA SUNROSE INTERNATIONAL CO LTD ROOM 22/2 227 JINMEI BUILDING NO 58 LANE 136 SUP SHUNDE ROAD, HAISHU DISTRICT NINGBO, ZHEJIANG CHINA NINGBO HAISHU WANQIANYAO TEXTILE CO LTD NO 197 SAN SAN ROAD CMT 26 62% 85% 0% WANGCHAN INDUSTRIAL ZONE NINGBO, ZHEJIANG CHINA ZHUJI JUNHANG SOCKS FACTORY DAMO VILLAGE LUXI NEW VILLAGE CMT 73 38% 66% 0% ZHUJI CITY ZHEJIANG CHINA SKYLEAD INDUSTRY CO LIMITED LAIMEI INDUSTRIAL PARK SUP CHENGHAI DISTRICT, SHANTOU CITY GUANGDONG CHINA CHUANGXIANG TOYS LIMITED LAIMEI INDUSTRIAL PARK CMT 49 33% 90% 0% CHENGHAI DISTRICT SHANTOU, GUANGDONG CHINA NINGBO ODESUN STATIONERY & GIFT CO LTD TONGJIA VILLAGE, PANHUO INDUSTRIAL ZONE SUP YINZHOU DISTRICT NINGBO CITY, ZHEJIANG CHINA NINGBO ODESUN STATIONERY & GIFT CO LTD TONGJIA VILLAGE, PANHUO INDUSTRIAL ZONE CMT YINZHOU DISTRICT NINGBO CITY, ZHEJIANG CHINA NINGBO WORTH INTERNATIONAL TRADE CO LTD RM. 1902 BUILDING B, CROWN WORLD TRADE PLAZA SUP NO. 1 LANE 28 BAIZHANG EAST ROAD NINGBO ZHEJIANG CHINA NINGHAI YUEMING METAL PRODUCT CO LTD NO. 5 HONGTA ROAD
    [Show full text]
  • Annual Report 2019 Annual Report
    Annual Report 2019 Annual Report 2019 For more information, please refer to : CONTENTS DEFINITIONS 2 Section I Important Notes 5 Section II Company Profile and Major Financial Information 6 Section III Company Business Overview 18 Section IV Discussion and Analysis on Operation 22 Section V Directors’ Report 61 Section VI Other Significant Events 76 Section VII Changes in Shares and Information on Shareholders 93 Section VIII Directors, Supervisors, Senior Management and Staff 99 Section IX Corporate Governance Report 119 Section X Independent Auditor’s Report 145 Section XI Consolidated Financial Statements 151 Appendix I Information on Securities Branches 276 Appendix II Information on Branch Offices 306 China Galaxy Securities Co., Ltd. Annual Report 2019 1 DEFINITIONS “A Share(s)” domestic shares in the share capital of the Company with a nominal value of RMB1.00 each, which is (are) listed on the SSE, subscribed for and traded in Renminbi “Articles of Association” the articles of association of the Company (as amended from time to time) “Board” or “Board of Directors” the board of Directors of the Company “CG Code” Corporate Governance Code and Corporate Governance Report set out in Appendix 14 to the Stock Exchange Listing Rules “Company”, “we” or “us” China Galaxy Securities Co., Ltd.（中國銀河證券股份有限公司）, a joint stock limited company incorporated in the PRC on 26 January 2007, whose H Shares are listed on the Hong Kong Stock Exchange (Stock Code: 06881), the A Shares of which are listed on the SSE (Stock Code: 601881) “Company Law”
    [Show full text]
  • 2020 Annual Report.Pdf
    HAITONG SECURITIES CO., LTD. 海通證券股份有限公司 Annual Report 2020 年度報告2020 年度報告 Annual Report 2020 CONTENTS Section I DEFINITIONS AND MATERIAL RISK WARNINGS 3 Section II COMPANY PROFILE AND KEY FINANCIAL INDICATORS 7 Section III SUMMARY OF THE COMPANY’S BUSINESS 25 Section IV REPORT OF THE BOARD OF DIRECTORS 33 Section V SIGNIFICANT EVENTS 85 Section VI CHANGES IN ORDINARY SHARES AND PARTICULARS ABOUT SHAREHOLDERS 123 Section VII PREFERENCE SHARES 136 Section VIII DIRECTORS, SUPERVISORS, SENIOR MANAGEMENT AND EMPLOYEES 137 Section IX CORPORATE GOVERNANCE 191 Section X CORPORATE BONDS 229 Section XI FINANCIAL REPORT 240 Section XII DOCUMENTS AVAILABLE FOR INSPECTION 241 Section XIII INFORMATION DISCLOSURES OF SECURITIES COMPANY 242 2 HAITONG SECURITIES CO., LTD. | Annual Report 2020 (H Share) IMPORTANT NOTICE The Board, the Supervisory Committee, Directors, Supervisors and senior management of the Company warrant the truthfulness, accuracy and completeness of contents of this annual report (the “Report”) and that there is no false representation, misleading statement contained herein or material omission from this Report, for which they will assume joint and several liabilities. This Report was considered and approved at the 15th meeting of the seventh session of the Board. All the Directors of the Company attended the Board meeting. None of the Directors or Supervisors has made any objection to this Report. PricewaterhouseCoopers Zhong Tian LLP (Special General Partnership) and PricewaterhouseCoopers have audited the annual financial reports of the Company prepared in accordance with PRC GAAP and IFRS respectively, and issued a standard and unqualified audit report of the Company. All financial data in this Report are denominated in RMB unless otherwise indicated.
    [Show full text]
  • Assessment on Island Ecological Vulnerability to Tourism Application to Zhoushan, China
    Ecological Indicators 113 (2020) 106247 Contents lists available at ScienceDirect Ecological Indicators journal homepage: www.elsevier.com/locate/ecolind Nouveauté or Cliché? Assessment on island ecological vulnerability to Tourism: Application to Zhoushan, China T ⁎ Xin Maa,b, , Martin de Jongc,d,e, Baiqing Suna, Xin Baoa a School of Management, Harbin Institute of Technology, 92 West Dazhi Street, Nan Gang District, Harbin 150001, China b School of Languages and Literature, Harbin Institute of Technology, 2 Wenhuaxi Road, Weihai 264209, China c Erasmus School of Law, Erasmus University Rotterdam, 3062 PA Rotterdam, The Netherlands d Rotterdam School of Management, Erasmus University Rotterdam, 3062 PA Rotterdam, The Netherlands e School of International Relations and Public Affairs, Fudan University, Shanghai 200433, China ARTICLE INFO ABSTRACT Keywords: In comparison with coastal zones, islands are even more vulnerable to anthropogenic disturbance, especially to Island ecological vulnerability (IEV) tourism and tourism-induced activities. Despite a great number of studies on either island tourism or island Island tourism vulnerability reviewed in this paper, knowledge and practice of the impact from tourism upon island ecological Coupling coordination degree modeling vulnerability (IEV) still needs to be expanded. In this contribution, the IEV of four administrative regions in (CCDM) Zhoushan, China is assessed between 2012 and 2017 based on an “exposure (E)-sensitivity (S)-adaptive capacity Zhoushan (A)” framework and by means of coupling
    [Show full text]
  • Company Brochure-CCPIT Zhejiag 1105
    Contents Ⅰ Textile and Garment 1. Stage Group Co., Ltd. 2. Wuchan Zhongda E-commerce Co.,Ltd 3. Zhejiang Shenzhou Woollen Textile Co., Ltd. 4. Zhejiang Linglong Textile Co., Ltd. 5. Zhejiang Tongxing Textile Science & Technology Development Co., Ltd. 6. Kaidi Silk Industry Co., LTD. 7. Mingda Group Co., Ltd. 8. Shaoxing Bolihao Hometextiles Co.,Ltd. 9. Jinhua Shijun Industrial Co., Ltd. 10. Jinhua Aishang Leather Goods Co.,Ltd 11. Pujiang Rongsheng Garment Factory Ⅱ Infrastructure and Energy 12. Hangzhou Dongheng Industrial Group Co., Ltd. 13. ZhouShan Marine Comprehensive Development and Investment Co.,Ltd. 14. Zhejiang Deye Investment Co., Ltd. 15. Zhoushan Water Group Co., Ltd.( cancel) 16. Jiashan Huayang Wooden&flocking Co.,Ltd. Ⅲ Processing and Manufacturing 17. Xinmingli Lighting Co.,Ltd. 18. Zhejiang Pan Casa Co.,Ltd. 19. Zhejiang L'meri Home Co.,Ltd. 20. Jinhua Ailanjie Automation Equipment Technology Co., Ltd. 21. Yongkang Arda Motor Co.,Ltd. 22. Zhejiang Myhome Kitchen Co.,Ltd. 23. Quzhou T-nine Tools Co.,Ltd. 24. Zhejiang Chengyuan Heavy Machinery Joint-Stock Co., Ltd. ⅣTrade andLogistics& Cultural and Tourism 25. Zhejiang Everbirght Development Corp. 26. Zhejiang Kaihom Logistics Co.,Ltd. 27. Zhejiang Runjiu Shipping Co., Ltd. 28. lulu&bewell 29. Jinhua Qun'an Trading Co.,Ltd. 30. Zhejiang Pingshanjinshui Culture& Communication Broadcast Co.,Ltd. ⅤElectronic Information and Security Services 31. Zhejiang Chinajoiner Information Technology Co., Ltd. 32. Zhejang Sunhope Electronic Technology Co., Ltd. 33. POPP Electric Co., Ltd.（cancel） 34. Zhejiang XINAN Intelligent Technology Co., Ltd. 35. Jinhua Jindong Security Service Co., Ltd. ⅥChemical Engineering and Medical Equipment 36. Zhejiang Polyker Fluorine Material Co., Ltd.
    [Show full text]
  • Can Arable Land Alone Ensure Food Security? the Concept of Arable Land Equivalent Unit and Its Implications in Zhoushan City, China
    sustainability Article Can Arable Land Alone Ensure Food Security? The Concept of Arable Land Equivalent Unit and Its Implications in Zhoushan City, China Yongzhong Tan 1,*, Ju He 1, Zhenning Yu 1,* ID and Yonghua Tan 2 1 Department of Land Management, Zhejiang University, Hangzhou 310058, China; [email protected] 2 Second Institute of Oceanography, State Oceanic Administration, Hangzhou 310012, China; [email protected] * Correspondence: [email protected] (Y.T.); [email protected] (Z.Y.); Tel.: +86-0571-56662137 (Y.T.); +86-0571-56662125 (Z.Y.) Received: 12 March 2018; Accepted: 28 March 2018; Published: 30 March 2018 Abstract: The requisition–compensation balance of farmlands (RCBF) is a strict Chinese policy that aims to ensure food security. However, the process of supplementing arable land has substantially damaged the ecological environment through the blind development of grasslands, woodlands, and wetlands to supplement arable land. Can arable land alone ensure food security? To answer this question, this study introduced the concepts of arable land equivalent unit (ALEU) and food equivalent unit (FEU) based on the idea of food security. Zhoushan City in Zhejiang Province, China was selected as the research area. This study analyzed the ALEU supply and demand capabilities in the study area and presented the corresponding policy implications for the RCBF improvement. The results showed that the proportion of ALEU from arable land and waters for aquaculture is from 46:54 in 2009 to 31:69 in 2015, thereby suggesting that aquaculture waters can also be important in food security. Under three different living standards (i.e., adequate food and clothing, well-off, and affluence), ALEU from arable land can barely meet the needs of the permanent resident population in the study area.
    [Show full text]
  • Bahrain Bangladesh Bhutan Bolivia
    BAHRAIN IDP Education - Bahrain Office Isa Town Mall Shop #20 (Behind Ahli United Bank) Building 3324, Road 1012, Block 810 PO Box 54159, Isa Town –Bahrain T: +973 1768 9960; +973 16632491 Email: [email protected] http://www.idp.com BANGLADESH Bada Education Centre - Bangladesh Office Barek Mansion-2, 58/9 (1st Floor) Free School Street, Box Culvert, Panthapath Dhaka 1205 T: + 880 174 9803 500 Email: [email protected] Website: http://www.badaedu.com BridgeBlue Pty Ltd - Dhaka Office Gulshan Lake Palace House 2-E (5th Floor) Road 29, Gulshan 1 Dhaka 1212 T: +8802 985 3002 Email: [email protected] http://www.AMSBBgroup.com IDP Education - Dhaka Office Hamid Tower 4th Floor Level 5, Gulshan Circle 2 Dhaka - 1212 T: +88 019 6878 2782; +88 09666 782 782 Website: http://www.idp.com IDP Education - Chittagong Office Rahima Center, (3rd Floor) 1839 CDA Avenue, Nasiarabad Chittagong (Besides Sanmar) T: +88 096 1233 3111; +88 019 7008 2082 Email: [email protected] Website: http://www.idp.com BHUTAN AMS BridgeBlue Pty Ltd – Bhutan Office 4F Gaa Phel Shopping Centre (next to Le Meridian Hotel) Chhoten Lam Thimphu 11001 T: +975 233 9559 Email: [email protected] Website: http://www.AMSBBgroup.com BOLIVIA Bada Education Centre – Bolivia Office Barrio Polanco, Radial 10 entre 3er y4to anillo Calle F, Torre Barcelona Santa Cruz de la Sierra Bolivia T: + 59 7261 7052 Email: [email protected] Website: http://www.badaedu.com Latino Australia Education – Bolivia Office Oficina Virtual T: +591 3340 6661 Email: [email protected] Website:
    [Show full text]