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Tomonidan Ithutuotte TOMONIDANUS010022425B2 ITHUTUOTTE (12 ) United States Patent (10 ) Patent No. : US 10 ,022 , 425 B2 Bancel et al. ( 45) Date of Patent : Jul. 17 , 2018 ( 54 ) ENGINEERED NUCLEIC ACIDS AND 4 , 399 ,216 A 8 / 1983 Axel et al. METHODS OF USE THEREOF 4 ,401 , 796 A 8 / 1983 Itakura 4 ,411 ,657 A 10 / 1983 Galindo 4 ,415 , 732 A 11/ 1983 Caruthers et al . @(71 ) Applicant : Moderna TX , Inc ., Cambridge , MA 4 ,458 , 066 A 7 / 1984 Caruthers et al. (US ) 4 , 474 , 569 A 10 / 1984 Newkirk 4 ,500 ,707 A 2 / 1985 Caruthers et al . @(72 ) Inventors : Stephane Bancel, Cambridge , MA 4 , 579 , 849 A 4 / 1986 MacCoss et al. 4 ,588 , 585 A 5 / 1986 Mark et al. (US ) ; Jason P . Schrum , Philadelphia , 4 ,668 , 777 A 5 / 1987 Caruthers et al . PA (US ) ; Alexander Aristarkhov , 4 , 737 ,462 A 4 / 1988 Mark et al . Chestnut Hill, MA (US ) 4 ,816 , 567 A 3 / 1989 Cabilly et al . 4 ,879 , 111 A 11 /1989 Chong ( 73 ) Assignee : ModernaTX , Inc. , Cambridge, MA 4 , 957 , 735 A 9 / 1990 Huang 4 , 959 , 314 A 9 / 1990 Mark et al. (US ) 4 ,973 ,679 A 11/ 1990 Caruthers et al. 5 ,012 ,818 A 5 / 1991 Joishy @( * ) Notice: Subject to any disclaimer, the term of this 5 ,017 ,691 A 5 / 1991 Lee et al. patent is extended or adjusted under 35 5 ,021 , 335 A 6 / 1991 Tecott et al. U . S . C . 154 (b ) by 0 days . 5 , 036 , 006 A 7 / 1991 Sanford et al . 5 , 047 ,524 A 9 / 1991 Andrus et al . @ 5 , 116 , 943 A 5 / 1992 Koths et al . ( 21 ) Appl . No .: 15 /266 , 791 5 , 130 , 238 A 7 / 1992 Malek et al . 5 , 132 ,418 A 7 / 1992 Caruthers et al. (22 ) Filed : Sep . 15 , 2016 5 , 153 , 319 A 10 / 1992 Caruthers et al . 5 , 168 , 038 A 12 / 1992 Tecott et al. (65 ) Prior Publication Data 5 , 169 , 766 A 12 / 1992 Schuster et al. 5 , 194 , 370 A 3 / 1993 Berninger et al. US 2017 /0065675 A1 Mar. 9 , 2017 5 , 199 , 441 A 4 / 1993 Hogle 5 , 240 , 855 A 8 / 1993 Tomes Related U . S . Application Data 5 ,262 , 530 A 11/ 1993 Andrus et al . 5 ,273 , 525 A 12 / 1993 Hofman (60 ) Division of application No . 14 /533 , 264 , filed on Nov. 5 , 298 ,422 A 3 / 1994 Schwartz et al. 5 , 2014 , now Pat . No . 9 , 464 , 124 , which is a 5 , 332 ,671 A 7 / 1994 Ferrara et al. 5 , 399 ,491 A 3 / 1995 Kacian et al . continuation of application No . 14 /342 , 905 , filed as 5 , 409 ,818 A 4 / 1995 Davey et al. application No. PCT/ US2012 / 054561 on Sep . 11 , 5 , 426 , 180 A 6 / 1995 Kool 2012 , now abandoned . 5 ,437 ,990 A 8 / 1995 Burg et al . 5 ,457 ,041 A 10 / 1995 Ginaven et al. ( 60 ) Provisional application No . 61/ 533 , 537, filed on Sep . 5 ,466 ,586 A 11/ 1995 Davey et al. 12 , 2011 . 5 , 484 ,401 A 1 / 1996 Rodriguez et al. 5 ,514 ,545 A 5 / 1996 Eberwine (51 ) Int. Ci. 5 , 527 , 288 A 6 / 1996 Gross et al. 5 , 545 , 522 A 8 / 1996 Van Gelder et al . A61K 49 / 00 ( 2006 .01 ) 5 , 554 , 517 A 9 / 1996 Davey et al . A61K 39 /00 ( 2006 .01 ) 5 ,580 ,859 A 12 / 1996 Felgner et al . A61K 39 / 38 ( 2006 .01 ) 5 , 588 , 960 A 12 / 1996 Edwards et al. A61K 38 / 17 ( 2006 .01 ) (Continued ) CO7K 14 /47 ( 2006 . 01 ) A61K 45 / 06 ( 2006 .01 ) FOREIGN PATENT DOCUMENTS A61K 38 /46 ( 2006 . 01 ) A61K 48 / 00 ( 2006 .01 ) CA 2376634 12 / 2000 ( 52 ) U . S . Ci. ?? 2473135 6 / 2003 CPC .. .. A61K 38 / 1729 (2013 . 01 ) ; A61K 38 /465 ( Continued ) (2013 .01 ) ; A61K 45 / 06 ( 2013 .01 ) ; A61K 48 /0075 (2013 .01 ) ; CO7K 14 /4723 (2013 . 01 ) ; OTHER PUBLICATIONS C12Y 301/ 27 (2013 . 01 ) ( 58 ) Field of Classification Search US 2002 /0198163 A1, 12 /2002 , Feigner et al. (withdrawn ) CPC . .. .. .. .. .. .. A61K 38 / 1729 ; A61K 47 / 00 ; A61K ( Continued ) 47 /48815 ; A61K 48 /00 Primary Examiner — Rodney P Swartz USPC . .. .. .. .. .. 424 / 9 . 1 , 9 . 2 , 184 . 1 , 185 . 1 (74 ) Attorney , Agent, or Firm — Wolf, Greenfield & See application file for complete search history. Sacks, P . C . ( 56 ) References Cited (57 ) ABSTRACT Provided are compositions and methods for delivering bio U . S . PATENT DOCUMENTS logical moieties such as modified nucleic acids into cells to 2 ,008 ,526 A 7 / 1935 Wrappler et al . kill or reduce the growth of microorganisms. Such compo 3 , 552 , 394 A 1 / 1971 Horn et al . sitions and methods include the use of modified messenger 3 , 737 , 524 A 6 / 1973 Ebel et al. RNAs, and are useful to treat or preventmicrobial infection , 3 , 766 , 907 A 10 / 1973 Muenzer 3 , 906 ,092 A 9 / 1975 Hilleman et al. or to improve a subject' s heath or wellbeing . 4 , 373 ,071 A 2 / 1983 Itakura 25 Claims, No Drawings US 10 ,022 ,425 B2 Page 2 (56 ) References Cited 6 , 300 ,484 B1 10/ 2001 Duhl 6 , 303 , 378 B1 10 /2001 Bridenbaugh et al . U . S . PATENT DOCUMENTS 6 , 303 , 573 B110 / 2001 Ruoslahti et al . 6 , 322 , 967 B1 11/ 2001 Parkin 5 , 589 , 466 A 12 / 1996 Felgner et al. 6 , 326 , 174 B1 12 / 2001 Joyce et al. 5 ,663 , 153 A 9 / 1997 Hutherson et al. 6 , 334, 856 B1 1 / 2002 Allen et al. 5 ,665 ,545 A 9 / 1997 Malek et al. 6 , 355 , 245 B1 3 /2002 Evans et al . 5 ,672 ,491 A 9 / 1997 Khosla et al. 6 , 368 , 801 B1 4 / 2002 Faruqi 5 ,674 , 267 A 10 / 1997 Mir et al . 6 , 376 , 248 B1 . 4 /2002 Hawley -Nelson et al . 5 ,677 ,124 A 10 / 1997 DuBois et al. 6 , 395 , 253 B2 5 / 2002 Levy et al. 5 ,679 ,512 A 10 / 1997 Laney et al. 6 , 399 , 061 B1 6 / 2002 Anderson et al . 5 ,693 ,622 A 12/ 1997 Wolff et al . 6 , 406 , 705 B1 6 / 2002 Davis et al . 5 ,693 , 761 A 12 / 1997 Queen et al . 6 , 410 , 276 B1 6 / 2002 Burg et al. 5 ,697 , 901 A 12 / 1997 Ericksson 6 , 413 , 942 B1 7 / 2002 Felgner et al. 5 , 700 ,642 A 12 / 1997 Monforte et al. 6 , 433 , 155 B1 8 / 2002 Umansky et al . 5 , 702 , 384 A 12 / 1997 Umeyama et al . 6 , 440, 096 B1 8 / 2002 Lastovich et al. 5 , 703 , 055 A 12 / 1997 Felgner et al. 6 , 455 , 043 B1 9 / 2002 Grillo - Lopez et al . 5 , 712 , 127 A 1 / 1998 Malek et al. 6 , 491 , 657 B2 12 / 2002 Rowe et al . 5 , 716 ,785 A 2 / 1998 Van Gelder et al. 6 , 500, 419 B1 12 / 2002 Hone et al. 5 , 736 , 137 A 4 / 1998 Anderson et al . 6 , 500, 919 B1 12 / 2002 Adema et al . 5 ,756 , 264 A 5 / 1998 Schwartz et al. 6 , 514 , 948 B1 2 / 2003 Raz et al. 5 , 759 , 179 A 6 / 1998 Balbierz 6 , 517 , 869 B1 2 / 2003 Park et al . 5 , 766 , 903 A 6 / 1998 Sarnow et al. 6 , 520 , 949 B2 2 / 2003 St . Germain 5 , 773 , 244 A 6 / 1998 Ares, Jr . et al . 6 , 525 ,183 B2 2 /2003 Vinayak et al. 5 , 776 , 456 A 7 / 1998 Anderson et al. 6 , 541 , 498 B2 2 / 2003 Antonsson et al. 5 , 789 ,554 A 8 / 1998 Leung et al. 6 , 527 , 216 B2 3 / 2003 Eagleman et al . 5 , 807 ,707 A 9 / 1998 Andrews et al. 6 , 528 , 262 B1 3 / 2003 Gilad et al . 5 , 824 , 307 A 10 / 1998 Johnson 6 , 534 ,312 B1 3 / 2003 Shiver et al . 5 , 824 ,497 A 10 / 1998 Andrews et al . 6 , 552, 006 B2 4 / 2003 Raz et al. 5 , 840 , 299 A 11/ 1998 Bendig et al. 6 , 555 , 525 B2 4 / 2003 Burke 5 , 843 , 439 A 12 / 1998 Anderson et al . 6 , 565 , 572 B2 5 /2003 Chappuis 5 , 848 , 996 A 12 / 1998 Eldor 6 , 572 , 857 B1 6 / 2003 Casimiro et al. 5 , 849 , 546 A 12 / 1998 Sousa et al . 6 , 586 , 524 B2 7 / 2003 Sagara 5 , 851, 829 A 12 / 1998 Marasco et al . 6 , 589 , 940 B1 7 / 2003 Raz et al . 5 , 861, 501 A 1 / 1999 Benseler et al . 6 , 610 , 044 B2 8 / 2003 Mathiesen 5 , 869, 230 A 2 / 1999 Sukhatme 6 , 610, 661 B1 8 / 2003 Carson et al. 5 , 889 , 136 A 3 / 1999 Scaringe et al . 6 , 613 , 026 B1 9 / 2003 Palasis et al . 5 ,891 ,636 A 4 / 1999 Van Gelder et al. 6 , 617, 106 B1 9 / 2003 Benner 5 ,914 ,269 A 6 / 1999 Bennett et al . 6 , 623 , 457 B1 9 / 2003 Rosenberg 5 , 955 , 310 A 9 / 1999 Widner et al. 6 ,652 , 886 B2 11/ 2003 Ahn et al . 5 ,958 ,688 A 9 / 1999 Eberwine et al . 6 ,653 ,468 B1 11 / 2003 Guzaev et al . 5 , 962, 271 A 10 / 1999 Chenchik et al. 6 ,664 , 066 B2 12 /2003 Parks 5 , 962 , 272 A 10 / 1999 Chenchik et al. 6 ,670 , 178 B1 12 / 2003 Selden et al . 5 , 965 ,720 A 10 / 1999 Gryaznov et al. 6 , 676 , 938 B1 1 /2004 Teti et al . 5 ,965 , 726 A 10 / 1999 Pavlakis et al. 6 ,696 , 038 B1 2 / 2004 Mahato et al.
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