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A61K 38 / 1729 ; A61K 47 / 00 ; A61K ( Continued ) 47 /48815 ; A61K 48 /00 Primary Examiner — Rodney P Swartz USPC . .. .. .. .. .. 424 / 9 . 1 , 9 . 2 , 184 . 1 , 185 . 1 (74 ) Attorney , Agent, or Firm — Wolf, Greenfield & See application file for complete search history. Sacks, P . C . ( 56 ) References Cited (57 ) ABSTRACT Provided are compositions and methods for delivering bio U . S . PATENT DOCUMENTS logical moieties such as modified nucleic acids into cells to 2 ,008 ,526 A 7 / 1935 Wrappler et al . kill or reduce the growth of microorganisms. Such compo 3 , 552 , 394 A 1 / 1971 Horn et al . sitions and methods include the use of modified messenger 3 , 737 , 524 A 6 / 1973 Ebel et al. 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