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A Profile of Robert Schimke May 2012 Living through art and science: a profile of Robert Schimke ALSO INSIDE THIS ISSUE: It’s award nomination season The community college culture American Society for Biochemistry and Molecular Biology Keep your cells happy ... ... with the POLARstar Omega microplate reader and the unique Atmospheric Control Unit (ACU). With its independent control of O2 and CO2, the POLARstar Omega microplate reader with integrated ACU represents a true “walk away“ solution for long term cell based assays. Tandem Technology UV/Vis Absorbance Spectra (220-1000 nm) Fluorescence Intensity incl. FRET Fluorescence Polarization TRF, TR-FRET incl. HTRF® and LanthaScreen® Growth curve of three Campylobacter Luminescence (flash and glow) strains using the POLARstar Omega ® ® AlphaScreen /AlphaLISA with the unique Atmospheric Control Unit. ACU – regulate O2 (1-19%) and CO2 (0-20%) For more information scan the QR code with your smart phone or visit us on www.bmglabtech.com T RANSCREENER™ T RANSCREENER™ T RANSCREENER™ Red TR-FRET validated www.bellbrooklabs.com HTRF is a registered trademark of Cisbio International. LanthaScreen is a registered trademark of Invitrogen Corporation. DLR is a trademark of Promega Corporation. AlphaScreen and AlphaLISA are registered trademarks of PerkinElmer, Inc. The Microplate Reader Company Transcreener is a registered trademark of BellBrook Labs. contents MAY 2012 On the cover: ASBMB Today science writer Rajendrani Mukhopadhyay news profiles Robert Schimke, whose lab made major 3 President’s Message contributions to at least four Credos for challenging times different areas of biology and who is now an artist. 12 5 News from the Hill Work-force diversity 6 Member Update Introducing the 8 JBC/Tabor Young Investigator Mildred Cohn Award. Award winners 10 9 New and updated annual awards 10 2013 award nominations welcome features 12 Living through art and science 19 NIH updates: 1000 Genomes Project and Lilly partnership 20 Gifts for new grads Can’t figure out what to buy that new grad in your life? Check out our list of departments must-have gifts. 20 22 Lipid News Reimagining neurometabolism 24 Journal News 24 JBC: Carolyn Cohen’s reflections on Find out about the seeing and knowing in structural biology first two winners in 2012 of JBC/Tabor 25 JLR: Potential drug target for treating Young Investigator lipid accumulation in fatty liver Awards. 8 26 MCP/JBC: Eicosanoid research of yesteryear and now 28 Minority Affairs U.S. health disparities at a glance 30 Education Reach out to your community college colleagues and students education A community college assistant professor addresses the 32 Open Channels well-documented repercussions of transfer shock and writes openly about her own experience with it decades ago to persuade others to help create a culture of undergraduate research at community colleges. Page 30 May 2012 ASBMB Today 1 onlineexclusives A monthly publication of www.asbmb.org/asbmbtoday The American Society for Biochemistry and Molecular Biology Officers Suzanne R. Pfeffer President ANNUAL Jeremy M. Berg President-Elect Mark A. Lemmon Secretary MEETING Merle S. Olson Treasurer Visit our who got (tem- Toni M. Antalis Treasurer-Elect COVERAGE Council Members website for porarily) inked Karen N. Allen Ruma V. Banerjee a transcript at the society’s Benjamin F. Cravatt Michael A. Marletta David Sabatini John D. Scott of tweets tattoo parlor Melissa Starovasnik Wesley I. Sundquist spurred by booth and Jonathan S. Weissman Ex-Officio Members our session on a roundup of Russell DeBose-Boyd communicating blogging about Hongtao Yu Co-chairs, 2012 Annual Meeting Program Committee science, a slide- symposia and Peter J. Kennelly Chair, Education and Professional Development show documenting special events. Committee Joan W. Conaway Chair, Meetings Committee Terri Kinzy Chair, Membership Committee Squire J. Booker Tune in to advocacy Chair, Minority Affairs Committee Bettie Sue Masters Earlier this spring, Chair, Public Affairs Advisory Committee Charles Brenner Hill Day was a multi- Chair, Publications Committee channel, multimedia Martha J. Fedor, Editor-in-chief, JBC Herbert Tabor, Co-editor, JBC affair, and we have Ralph A. Bradshaw videos to prove it. A. L. Burlingame Co-editors, MCP Hear from the 2012 Edward A. Dennis Joseph L. Witztum cohort of ASBMB Co-editors, JLR members on our ASBMB Today Editorial Advisory Board website. Alex Toker (Chair) Mike Bradley Craig E. Cameron A. Stephen Dahms Alex C. Drohat Ben Ellington Irwin Fridovich Richard W. Hanson Gerald Hart Peter Kennelly Carol C. Shoulders Complementary skills: What they ASBMB Today Angela Hopp Editor are and how to develop them [email protected] Rajendrani Mukhopadhyay In the coming months, ASBMB Today contribu- Sr. Science Writer / Editor tor Aruni S. Arachchige Don will report on a [email protected] Erin Salb Production Coordinator variety of skills that young scientists should [email protected] acquire to advance their careers— both inside Nancy J. Rodnan Director of Publications [email protected] and outside of the lab. Read her introductory Barbara Gordon Executive Director column at www.asbmb.org/asbmbtoday this [email protected] month, and look for her forthcoming discus- For information on advertising, contact Capitol Media Solutions at 800-517-0610 sions about important skills, such as com- or [email protected] munication, leadership, management, profes- sionalism, research conduct and professional and social networking. She’ll offer insights from professional communicators, leadership www.asbmb.org/asbmbtoday and ethics specialists, and those who make a living using social media to advance causes and careers. May 2012 president’smessage Credos for challenging times BY SUZANNE PFEFFER ave biochemists and molecular biologists become stupid the comments may sometimes seem. Reviewers Hmore cranky in recent years? I think so. For exam- do help authors improve papers – they just should do ple, there was a time when manuscript reviews would this constructively and with sensitivity. come back with warm praise and a highly construc- I have heard it said, “A day planning experiments tive tone. I once received a review in which the referee can be more valuable than a week doing experiments.” took the time to make suggestions about grammatical Mike Brown and Joe Goldstein chide their students usage that were very much appreciated by this then- that it is always “pH before Ph.D.” My former colleague assistant professor. That kind of review doesn’t need Arthur Kornberg was well known for saying, “Don’t to be rare: Each of us can be the change we wish to waste clean thoughts on dirty enzymes.” Another credo see, as the saying goes. Referees should remember I like is “Don’t be greedy.” This one applies when a that their comments are not just directed at a lab head; student complains that half the expressed enzyme is reviews have the biggest impact on the students and insoluble. I say, focus on the great yield in the soluble postdocs who have to respond to each of the points fraction! raised with additional data and, certainly, some level of discouragement. A vicious cycle can start with a critical or seemingly unfair manuscript review. Crankiness can escalate: How we treat each other can mirror how we feel we are treated. Are referees asking for more and more information for a single manuscript each year? Who decided that more was needed? All of us did, as authors, grant applicants, reviewers and editors, somewhere along the line. We calibrate reviews of papers and grants by what we perceive the state of the field to be— which we learn by looking at what other published papers (or funded grants) include and what other reviews look like. Gregory A. Petsko and Dagmar Ringe are both professors of I recently submitted a manuscript to a journal that biochemistry and chemistry at Brandeis University, where they is expressly designed to publish papers that present jointly run a laboratory. new information, requiring only that the conclusions be justified by the data. This story was part of a graduate Greg Petsko and Dagmar Ringe student’s very challenging thesis; the highly significant have a set of rules for their results were just out of reach, and it was time for this man to graduate. One reviewer thought it was just fine; jointly run lab that I find useful. the other reviewed the work as if it had been submitted 1. If you think you know the answer, to a much fancier journal. There was no appeasing this you will get that answer, even if it’s reviewer, despite my attempt to remind him or her which the wrong answer. journal we had selected. So a new lab member did all that was asked; at last, the significance of the findings 2. Never confuse an assumption with took a major leap forward, and we resubmitted a fully a fact. revised manuscript to a journal of much higher repute. I remind my lab members that I have never seen a 3. One good experiment is worth paper that is not improved upon revision, no matter how a thousand expert opinions. May 2012 ASBMB Today 3 firstpresident’ssecondmessagecontinuedcontinued 4. The strong shall take from the 16. Create an environment where weak, but the smart shall take from people can learn and have fun the strong. learning, and the work will take care of itself. The results are just 5. Take nothing on faith. Things are the report card. frequently not what they seem to Be your own toughest referee. be or what people tell you they are. 17. Whenever you get a result that Check everything. you expected or that you think you understand, always ask, “How 6. Excellence is the result of preparation, planning, imagination might nature be trying to fool me?” and tenacity. Neglect any one of 18. Be generous to your coworkers, these and the result is mediocrity.
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