Mapping Multiple Mutations See Biobits Page 28
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Unrestricted Immigration and the Foreign Dominance Of
Unrestricted Immigration and the Foreign Dominance of United States Nobel Prize Winners in Science: Irrefutable Data and Exemplary Family Narratives—Backup Data and Information Andrew A. Beveridge, Queens and Graduate Center CUNY and Social Explorer, Inc. Lynn Caporale, Strategic Scientific Advisor and Author The following slides were presented at the recent meeting of the American Association for the Advancement of Science. This project and paper is an outgrowth of that session, and will combine qualitative data on Nobel Prize Winners family histories along with analyses of the pattern of Nobel Winners. The first set of slides show some of the patterns so far found, and will be augmented for the formal paper. The second set of slides shows some examples of the Nobel families. The authors a developing a systematic data base of Nobel Winners (mainly US), their careers and their family histories. This turned out to be much more challenging than expected, since many winners do not emphasize their family origins in their own biographies or autobiographies or other commentary. Dr. Caporale has reached out to some laureates or their families to elicit that information. We plan to systematically compare the laureates to the population in the US at large, including immigrants and non‐immigrants at various periods. Outline of Presentation • A preliminary examination of the 609 Nobel Prize Winners, 291 of whom were at an American Institution when they received the Nobel in physics, chemistry or physiology and medicine • Will look at patterns of -
MED C-LIVE Transcript
JUNE 2020 Mario Capecchi, Ph.D. NOT FOR PUBLIC DISTRIBUTION Michael Keel My name is Michael Keel from New Jersey. And it is my honor to introduce Dr. Mario Capecchi. Dr. Capecchi is the Distinguished Professor of Human Genetics at the University of Utah School of Medicine. He is best known for his groundbreaking work in gene targeting, in mass embryo derived stem cells. He was awarded the Nobel Prize in Physiology for Medicine, for his work in finding ways to manipulate the mammalian genome by changing mammals’ genes. His research interests include analysis of neural development in mammals, gene therapy, and production of murine models of human genetic diseases, from cancer to neuropsychiatric disorders. Dr. Capecchi, welcome to the Congress of Future Medical Leaders. Dr. Capecchi Thank you. First of all, welcome to the Medical Leaders’ Congress. It's a pleasure to be here. My name is Mario. I'm going to be talking about gene targeting. Next slide please. My laboratory has developed a technology called gene targeting that allows you to change any gene in any conceivable manner in a living creature, such as a mouse. Next slide. Why do we do gene targeting? Next slide. There are many reasons, but they boil down to two. One is basic research and the other is applied research. In basic research, you investigate the biology of an animal. For example, how do you make a limb or a heart or a brain? Those are basic research questions. The other is applied research. That is we can use gene targeting to generate mice with human diseases. -
Kohen Curriculum Vitae
Curriculum Vitae Amnon Kohen Department of Chemistry Tel: (319) 335-0234 University of Iowa FAX: (319) 335-1270 Iowa City, IA 52242 [email protected] EDUCATION AND PROFESSIONAL HISTORY Education D.Sc., Chemistry 1989-1994 Technion – Israel Institute of Technology, Haifa, Israel Advisor: Professor T. Baasov Topic: Mechanistic Studies of the Enzyme KDO8P Synthase B.Sc., Chemistry (with Honors) 1986-1989 Hebrew University, Jerusalem, Israel Positions Professor 2010-Present Department of Chemistry, University of Iowa, Iowa City, IA and Molecular and Cellular Biology Program, and MSTP faculty member Associate Professor 2005-2010 Department of Chemistry, University of Iowa, Iowa City, IA and Molecular and Cellular Biology Program Assistant Professor 1999-2005 Department of Chemistry, University of Iowa, Iowa City, IA Postgraduate Researcher 1997-1999 With Professor Judith Klinman Department of Chemistry, University of California, Berkeley Topic: Hydrogen Tunneling in Biology: Alcohol Dehydrogenases Postgraduate Fellow 1995-1997 With Professor Judith Klinman Department of Chemistry, University of California, Berkeley Topic: Hydrogen Tunneling in Biology: Glucose Oxidase Visiting Scholar Fall 1994 With Professor Karen S. Anderson Department of Pharmacology, Yale Medical School, New Haven, CT Kohen, A. Affiliations American Society for Biochemistry and Molecular Biology (ASBMB, 2013 - present) Center for Biocatalysis and Bioprocessing (CBB) University of Iowa (2000-Present) The Interdisciplinary Graduate Program in Molecular Biology, University of Iowa (2003- Present) American Association for the Advancement of Science (AAAS, 2011-present) American Chemical Society (1995-Present) Divisions: Organic Chemistry, Physical Chemistry, Biochemistry Sigma Xi (1997-Present) Protein Society (1996-1998) Honors and Awards • Career Development Award (University of Iowa- 2015-2016) • Graduate College Outstanding Faculty Mentor Award (2015). -
The Promise of Human Genome Editing for Rare and Genetic Disease Summary Report of the 2019 FORUM Annual Lecture
The promise of human genome editing for rare and genetic disease Summary report of the 2019 FORUM Annual Lecture The Academy of Medical Sciences The Academy of Medical Sciences is the independent body in the UK representing the diversity of medical science. Our mission is to promote medical science and its translation into benefits for society. The Academy’s elected Fellows are the United Kingdom’s leading medical scientists from hospitals, academia, industry and the public service. We work with them to promote excellence, influence policy to improve health and wealth, nurture the next generation of medical researchers, link academia, industry and the NHS, seize international opportunities and encourage dialogue about the medical sciences. Opinions expressed in this report do not necessarily represent the views of all participants at the event, the Academy of Medical Sciences, or its Fellows. All web references were accessed in February 2020. This work is © Academy of Medical Sciences and is licensed under Creative Commons Attribution 4.0 International. The Academy of Medical Sciences 3 The promise of human genome editing for rare and genetic disease Summary report of the 2019 FORUM Annual Lecture Contents Executive summary .................................................................................................... 4 An introduction to genome editing ................................................................................ 6 Genome editing: moving to the clinic ........................................................................... -
2004 Albert Lasker Nomination Form
albert and mary lasker foundation 110 East 42nd Street Suite 1300 New York, ny 10017 November 3, 2003 tel 212 286-0222 fax 212 286-0924 Greetings: www.laskerfoundation.org james w. fordyce On behalf of the Albert and Mary Lasker Foundation, I invite you to submit a nomination Chairman neen hunt, ed.d. for the 2004 Albert Lasker Medical Research Awards. President mrs. anne b. fordyce The Awards will be offered in three categories: Basic Medical Research, Clinical Medical Vice President Research, and Special Achievement in Medical Science. This is the 59th year of these christopher w. brody Treasurer awards. Since the program was first established in 1944, 68 Lasker Laureates have later w. michael brown Secretary won Nobel Prizes. Additional information on previous Lasker Laureates can be found jordan u. gutterman, m.d. online at our web site http://www.laskerfoundation.org. Representative Albert Lasker Medical Research Awards Program Nominations that have been made in previous years may be updated and resubmitted in purnell w. choppin, m.d. accordance with the instructions on page 2 of this nomination booklet. daniel e. koshland, jr., ph.d. mrs. william mccormick blair, jr. the honorable mark o. hatfied Nominations should be received by the Foundation no later than February 2, 2004. Directors Emeritus A distinguished panel of jurors will select the scientists to be honored. The 2004 Albert Lasker Medical Research Awards will be presented at a luncheon ceremony given by the Foundation in New York City on Friday, October 1, 2004. Sincerely, Joseph L. Goldstein, M.D. Chairman, Awards Jury Albert Lasker Medical Research Awards ALBERT LASKER MEDICAL2004 RESEARCH AWARDS PURPOSE AND DESCRIPTION OF THE AWARDS The major purpose of these Awards is to recognize and honor individuals who have made signifi- cant contributions in basic or clinical research in diseases that are the main cause of death and disability. -
Curriculum Vitae Natalie G. Ahn
Natalie G. Ahn Curriculum Vitae Natalie G. Ahn ADDRESS: Department of Biochemistry Jennie Smoly Caruthers Biotechnology Building 3415 Colorado Avenue, 596 UCB University of Colorado at Boulder Boulder, CO 80309-0596 Phone: (303) 492-4799 (Phone) Email: [email protected] I. ACADEMICS EDUCATION Postdoctoral Fellow, 1988-1990, Department of Pharmacology, Univ. of Washington, Seattle Research advisor: Edwin G. Krebs Postdoctoral Fellow, 1985-1987, Department of Medicine, Univ of Washington, Seattle Research advisor: Christoph de Haën Ph.D.,1985, Department of Chemistry University of California, Berkeley Thesis advisor: Judith P. Klinman 1979-1981 Teaching Assistant, undergraduate chemistry, Dept. of Chemistry 1981-1985 Research Assistant, Dept. of Chemistry B.S., 1979, Department of Chemistry, University of Washington, Seattle Undergraduate senior thesis advisor: Lyle H. Jensen, Department of Biological Structure Undergraduate research advisor: David C. Teller, Department of Biochemistry APPOINTMENTS 2018-present Distinguished Professor, University of Colorado 2003-present Associate Director, BioFrontiers Institute, Univ. Colorado, Boulder 1994-2014 Investigator, Howard Hughes Medical Institute (1994-2002 Assistant Investigator; 2003-2004 Associate Investigator; 2005-2014 Investigator) 1993-present Member, UCHSC Cancer Center, Univ. Colorado Health Sciences Center, Denver 1992-2018 Professor, Department of Chemistry and Biochemistry, Univ. Colorado, Boulder (1992-1998 Assistant Professor; 1998-2003 Associate Professor; 2003-present Professor) 1990-1992 Research Assistant Professor, Department of Biochemistry, Univ. Washington, Seattle 3 Natalie G. Ahn II. HONORS 2018 Distinguished Professor, University of Colorado 2018 Member, National Academy of Sciences 2018 Member, American Academy of Arts and Sciences 2016-2018 President, American Society of Biochemistry and Molecular Biology 2012 Professor of Distinction, College of Arts & Sciences, U. -
Official Gazette
OFFICIAL GAZETTE EDITION GOVERNMENT PRINTIG BUREAU ENGLISH 08≫--t--#+--.fl=-1-HJB=SB!flitMBTtf EXTRA WEDNESDAY, APRIL 7, 1948 ASAKURA, Tadataka 'ASAKURA, Kan-ichi NOTICE DOTEI, Yujiro EGUCHI, Shiro ETO, Shinobu ENDO, Kiyoshi Public Notice of Screening Results No. 28 FUCHI, Kataaki FUJIMAKl', Kiohiro (March 16―March 31, 1948) FUJIMOTO, Ka:suhiko FUJITA, Yuji HAGUiMA, Kazuo HAMADA, Kazuo April 7, 1948 HANASE, Saburo HARA, Akira Director-General of Cabinet Secretariat HAYASHI Fujimaru HAYASHI, Fumiko TOMABECHI Gizo ≪, HAYASHI, Shigenori HIRAKAWA, Katamitsu 1. This table shows the screening result of the HIRAMATSU, Hideo HIRATA, Sadaichi Central Public Office Qualifications Examination HISAGANE, Akira HISATOMI, Yoshitsugu Committee, in accordance with the provisions of HISAYA, Yasuyoshi HOSHINO, Hideo Imperial Ordinance No. 1 of the same year. IEMORI, Hidetaro IGARASHI, Morishi 2. This table is to be most widely made public. IIDA, Shfro IIZUKA, Yoshihiko The office of a city, ward, town or village, shall IMAIZUMI, Kyojiro INOUE, Masao placard, upon receipt of this official report the IRI, Sadayo ISHIDA Taichiro said table. This table shall be at least placarded ISHIKAWA, Jun ITAKURA, Sadahisa for a month, and it shall, upon receipt of the ITO, Yoshitaka ITO, Yukuo next official report, be replaced by a new one. IWANAGA, "Sukegoro IWAO Akio The old report which is replaced, shall not be KABAYAMA, Hisao KAGURAI, Suzukazu destroyed, but be cound and preserved at the KAIBARA, Tsutomu KAJIYA, Mibujiro office of the city, ward, town or village, -
The Member Magazine of the American Society for Biochemistry and Molecular Biology CONTENTS
Vol. 13 / No. 5 / May 2014 THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY CONTENTS NEWS FEATURES PERSPECTIVES 2 14 18 PRESIDENT’S MESSAGE PROPAGATING POSSIBILITIES OPEN LETTER Good reads and the power of data Researcher tinkers with tree genetics On hindsight and gratitude 5 19 NEWS FROM THE HILL PROFESSIONAL DEVELOPMENT Making scientic research 11 19 Tips for Ruth L. Kirschstein training a priority for Congress grant applicants 21 e skills you need for 6 a career in science policy MEMBER UPDATE 22 Give credit where it is due ACS honors nine ASBMB members 24 7 EDUCATION JOURNAL NEWS 24 Reimagining the undergraduate 18 science course 12 27 ‘Creativity is in all – not a possession ASBMB NEWS of only a certain few’ 2014 annual meeting travel award winners 28 OUTREACH Yale Science Diplomats 28 31 LIPID NEWS Desperately seeking Sputnik for fundamental science 32 OPEN CHANNELS Reader comments 14 12 In our cover story, we learn about one research team’s eort to manipulate common trees to produce high-value commodities. MAY 2014 ASBMB TODAY 1 PRESIDENT’S MESSAGE calibration curves are much worse. tomy for breast cancer by surgeon perpetually changing landscape of is is particularly true for the local William Halsted and the implications breast cancer was beginning to tire THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY television forecasts: ey substantially of studies of its eectiveness. Moving him out. Trials, tables, and charts FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY Good reads and overpredict the probability of rain. past surgical treatments that focused had never been his forte; he was a is tendency gets at a key point. -
Shigekazu Nagata Is Better Known for His Work on Apoptosis
© 2001 Nature Publishing Group http://medicine.nature.com NEWS Having originally researched the activities of the potent hematopeotic stimulator of bone-marrow cells, granulocyte colony stimulating factor, Shigekazu Nagata is better known for his work on apoptosis. Here, one of Japan’s most renowned biomedical scientists outlines the path that has taken him full circle: from stimulating cells to grow, to finding out how they die, to tying the two processes together. Shigekazu Nagata For a man who spends most of his time clusively activated in apoptosis. He says Charles Weissmann. He took the job be- thinking about death, Shigekazu Nagata is there are several questions left to be an- cause at that time, “almost no one was remarkably upbeat. For over a decade, he swered concerning the Fas pathway. using recombinant DNA technology in has been making a name for himself with Central among them is, how does the onco- Japan.” He credits his experience in research on apoptosis, the mechanism of gene product Bcl-2 block apoptosis? Weissman’s lab with forming the basis for programmed cell death, and during that However, he has no personal plans to work his future studies and teaching him an “or- time he has watched the field come alive. on an answer to that question, perhaps be- derliness and logical procedure” to re- “Medline publications on apoptosis have cause he has become a victim of his own search. In 1982, he returned to IMS for a risen from only a couple of hundred in success at propagating interest in cell death. short time before moving to the OBI in 1990 to over 10,000 this year,” he says with “There are so many other 1987 and then to taking up a satisfied nod. -
BBSRC Annual Report and Accounts 2007-08 HC
ANNUAL REPORT & ACCOUNTS 2007-2008 Biotechnology and Biological Sciences Research Council ANNUAL REPORT & ACCOUNTS 2007-2008 Presented to Parliament by the Secretary of State, and by the Comptroller and Auditor General, in pursuance of Schedule 1, Sections 2 [2] and 3 [3] of the Science and Technology Act 1965. Ordered to be printed by the House of Commons 16 July 2008. HC761 LONDON: The Stationery Office £18.55 Contents PART 1: MANAGEMENT COMMENTARY Chairman’s statement 1 Chief Executive’s report 3 Supporting world class research 6 Key funding data 7 Embedding Systems Biology 11 Major collaborative and multidisciplinary programmes 12 Delivering economic and social benefits 14 Collaborative research with industry 14 Commercialising research outputs 17 Tackling major challenges 20 People, skills, training and knowledge flows 22 Embedding our science in society 26 Opinion gathering and public dialogue 26 Outreach and engagement 28 Engaging young people in science 29 Corporate information 30 2007-2008 Council 30 Boards, Panels and Committees 31 Organisational developments 36 Financial review 39 Remuneration report 42 PART 2: ANNUAL ACCOUNTS Financial statements for the year ended 31 March 2008 45 This Annual Report covers the period from 1 April 2007 to 31 March 2008. BBSRC ANNUAL REPORT & ACCOUNTS BBSRC ANNUAL The Biotechnology and Biological Sciences Research Council (BBSRC), established by Royal Charter in 1994, is the UK’s principal funder of basic and strategic research across the biosciences (www. bbsrc.ac.uk). It is funded primarily by the Science Budget, through the Department for Innovation, Universities and Skills (DIUS). Our mission is to support high-class science and research training, and to promote knowledge transfer in support of bio-based industries and public engagement in bioscience. -
Winter for the Membership of the American Crystallographic Association, P.O
AMERICAN CRYSTALLOGRAPHIC ASSOCIATION NEWSLETTER Number 4 Winter 2004 ACA 2005 Transactions Symposium New Horizons in Structure Based Drug Discovery Table of Contents / President's Column Winter 2004 Table of Contents President's Column Presidentʼs Column ........................................................... 1-2 The fall ACA Council Guest Editoral: .................................................................2-3 meeting took place in early 2004 ACA Election Results ................................................ 4 November. At this time, News from Canada / Position Available .............................. 6 Council made a few deci- sions, based upon input ACA Committee Report / Web Watch ................................ 8 from the membership. First ACA 2004 Chicago .............................................9-29, 38-40 and foremost, many will Workshop Reports ...................................................... 9-12 be pleased to know that a Travel Award Winners / Commercial Exhibitors ...... 14-23 satisfactory venue for the McPherson Fankuchen Address ................................38-40 2006 summer meeting was News of Crystallographers ...........................................30-37 found. The meeting will be Awards: Janssen/Aminoff/Perutz ..............................30-33 held at the Sheraton Waikiki Obituaries: Blow/Alexander/McMurdie .................... 33-37 Hotel in Honolulu, July 22-27, 2005. Council is ACA Summer Schools / 2005 Etter Award ..................42-44 particularly appreciative of Database Update: -
Final Program of LAMP2015
LAMP2015 The 7th International Congress on Laser Advanced Materials Processing LPM2015–The 16th International Symposium on Laser Precision Microfabrication HPL2015–The 7th International Symposium on High Power Laser Processing May 26 – 29, 2015 Kitakyushu, Fukuoka, Japan http://www.jlps.gr.jp/lamp/lamp2015/ Final Program updated May 20, 2015 General Chair Koji Sugioka RIKEN, Japan Co-Chair/LPM Program Committee Chair Hiroyuki Niino AIST, Japan Co-Chair/HPL Program Committee Chair Seiji Katayama Osaka University, Japan Co-Chair Takashi Ishide Mitsubishi Heavy Industries, Japan Co-Chair Yongfeng Lu University of Nebrasska-Lincoln, USA Co-Chair Michael Schmidt Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany Honorary Chair Isamu Miyamoto Emeritus Prof., Osaka University, Japan Honorary Chair Kazuyoshi Itoh Emeritus Prof., Osaka University, Japan Steering Committee Chair Tatsuo Okada Kyushu University, Japan Steering Committee Co-Chair (LPM) Toshihiko Ooie AIST, Japan Steering Committee Co-Chair (HPL) Takashi Ishide Mitsubishi Heavy Industries, Ltd., Japan Contents Program 1 Author Index 34 Program Program Program Oral Session Oral Session Day 1: May 26, Tuesday Main Hall Opening Day 1: May 26, Tuesday Chair: Koji Sugioka (RIKEN, Japan) 10:30 Opening Remark Main Hall Plenary Session Chair: Takashi Ishide (Mitsubishi Heavy Industries, Inc., Japan) 10:40 TuM-PL-1 Plenary A276 Latest developments in high precision ultrafast laser processing, Andreas Ostendorf1, 1Ruhr-University Bochum, Germany 11:20 TuM-PL-2 Plenary A249 Fundamentals and evolution of laser welding, Seiji Katayama1, 1JWRI, Osaka University, Japan 12:00 TuM-PL-3 Plenary A145 The state of the arts of laser manufacturing and future prospect , Bo Gu1, 1Bos Photonics, USA 12:40 Lunch Time 3 updated May 20, 2015 Oral Session 1.