Psychiatry and Stigmatization
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Histamine in Psychiatry: Promethazine As a Sedative Anticholinergic
BJPsych Advances (2019), vol. 25, 265–268 doi: 10.1192/bja.2019.21 CLINICAL Histamine in psychiatry: REFLECTION promethazine as a sedative anticholinergic John Cookson (strongly influenced by the ideas of Claude Bernard John Cookson, FRCPsych, FRCP, is SUMMARY and Louis Pasteur). There he met Filomena Nitti, a consultant in general adult psych- iatry for the Royal London Hospital The author reflects on discoveries over the course daughter of a former prime minister of Italy. They of a century concerning histamine as a potent and East London NHS Foundation married in 1938 and she became her husband’slife- chemical signal and neurotransmitter, the develop- Trust. He trained in physiology and long co-worker. They moved in 1947 to the pharmacology at the University of ment of antihistamines, including promethazine, Institute of Health in Rome. In 1957 he was Oxford and he has a career-long and chlorpromazine from a common precursor, interest in psychopharmacology. His and the recognition of a major brain pathway awarded a Nobel Prize for his work in developing duties have included work in psychi- involving histamine. Although chlorpromazine has drugs ‘blocking the effects of certain substances atric intensive care units since 1988. been succeeded by numerous other antipsycho- occurring in the body, especially in its blood vessels He has co-authored two editions of tics, promethazine remains the antihistamine and skeletal muscles’ (Oliverio 1994). He and his Use of Drugs in Psychiatry, published recommended for sedation in acutely disturbed by Gaskell. research student Marianne Staub introduced the Correspondence: Dr John Cookson, patients, largely because it is potently anticholiner- first antihistamine in 1937, developed by altering Tower Hamlets Centre for Mental gic at atropinic muscarinic receptors and therefore the structures of drugs found to block known trans- Health, Mile End Hospital, Bancroft anti-Parkinsonian: this means it is also useful in mitters – acetylcholine and adrenaline – such as atro- Road, London E1 4DG, UK. -
Jean Delay Preamble
1 Barry Blackwell: Pioneers and Controversies in Psychopharmacology Chapter Six: Jean Delay Preamble Jean Delay is perhaps best remembered for the discovery of Chlorpromazine, the first effective drug for the treatment resistant psychotic men and women who filled the world’s asylums in the mid twentieth century. Compared to Delay’s other scientific and literary accomplishments, as told in Driss Moussai’s biography, his role in this discovery was largely conceptual and clinically modest, but as was customary in hierarchical French academia, Delay’s name came first on scientific publications. The clinical work was conducted by Pierre Deniker and an intern in his department, J.M. Harl, who died prematurely in a mountain climbing accident. Deniker described the early work in detail (Deniker, 1970) when he received the Taylor Manor Award for the discovery and presented his paper, “Introduction of Neuroleptic Chemotherapy.” “Logically a new drug was tried in cases resistant to all existing therapies. We had scarcely treated 10 patients - with all due respect to fervent adherents of statistics - when our conviction proved correct. It was supported by the sudden, great interest of nursing personnel, who had always been reserved about innovations.” When the first paper was presented to the French Medico-Psychological Society at a meeting on shock or sleep therapy the effect was described as ”neuroleptic” – effecting the neuron - in cases of “manic excitation, and more generally, psychotic patients who were often resistant to shock or sleep therapy.” The specific effects were noted on “agitation, aggressiveness and delusive conditions of schizophrenia which improved. Contact with patients could be re-established, but deficiency symptoms did not change markedly.” When six definitive papers were published between May and June 1952 these observations had been made on only 38 patients without any attempt at controlled design (Delay, Deniker and Harl 1952). -
On Henry Miller
© Copyright, Princeton University Press. No part of this book may be distributed, posted, or reproduced in any form by digital or mechanical means without prior written permission of the publisher. In Praise of Flight There is no salvation in becoming adapted to a world which is crazy. — Henry Miller, The Colossus of Maroussi La fuite reste souvent, loin des côtes, la seule façon de sauver le bateau et son équipage. Elle permet aussi de découvrir des rivages inconnus qui surgiront à l’horizon des calmes retrouvés. Rivages inconnus qu’ignoreront toujours ceux qui ont la chance apparente de pouvoir suivre la route des cargos et des tankers, la route sans imprévu imposée par les compagnies de trans- port maritime. Vous connaissez sans doute un voilier nommé “Désir.” — Henri Laborit, Éloge de la fuite A man wakes. He knows exactly what is going to happen today, or at least he thinks he does (like everyone, he knows that the unexpected might occur at any time, that he might go to see his doctor and be told he has an inoperable cancer, or his girlfriend, who stood by him all through that messy divorce, will call him at the office mid- morning to say that she has met someone else, but he keeps the thought of random harm • 1 For general queries, contact [email protected] © Copyright, Princeton University Press. No part of this book may be distributed, posted, or reproduced in any form by digital or mechanical means without prior written permission of the publisher. at bay as well as he is able, usually by means of a combination of superstition, moral duplicity, and steady, if uninventive, self- medication). -
Toxicol Rev 2004; 23 (1): 21-31 GHB SYMPOSIUM 1176-2551/04/0001-0021/$31.00/0
Toxicol Rev 2004; 23 (1): 21-31 GHB SYMPOSIUM 1176-2551/04/0001-0021/$31.00/0 2004 Adis Data Information BV. All rights reserved. γ-Butyrolactone and 1,4-Butanediol Abused Analogues of γ-Hydroxybutyrate Robert B. Palmer1,2 1 Toxicology Associates, Prof LLC, Denver, Colorado, USA 2 Rocky Mountain Poison & Drug Center, Denver, Colorado, USA Contents Abstract ................................................................................................................21 1. Clinical Effects .......................................................................................................23 2. Diagnosis and Management ..........................................................................................25 3. Withdrawal ..........................................................................................................26 4. Conclusion ..........................................................................................................29 Abstract γ-Hydroxybutyrate (GHB) is a GABA-active CNS depressant, commonly used as a drug of abuse. In the early 1990s, the US Drug Enforcement Administration (DEA) warned against the use of GHB and restricted its sale. This diminished availability of GHB caused a shift toward GHB analogues such as γ-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) as precursors and surrogates. Both GBL and 1,4-BD are metabolically converted to GHB. Furthermore, GBL is commonly used as a starting material for chemical conversion to GHB. As such, the clinical presentation and management of GBL and 1,4-BD -
A Modo De Fichas Sobre Clásicos De La Psiquiatría: Jean Delay Y El Nacimiento De La Psicofarmacología Moderna
A modo de fichas sobre clásicos de la Psiquiatría: Jean Delay y el nacimiento de la psicofarmacología moderna Reda Rahmani y Luis Pacheco Su vida: Jean Delay nació el 14 de noviembre de 1907 en El recorrido académico de Jean Delay es la Bayona, hijo único de Maurice Delay y Berthe historia de una conquista sin pausa. Mihura. Según su colega Pierre Deniker, tenía Dirigiéndose a él, Léon Bérard, miembro de la absoluta admiración por su madre y le dedicaría academia francesa, dirá: “su carrera nos en vida gran parte de sus obras. Su padre, antes sorprende por una especie de regularidad e de llegar a ser alcalde de la ciudad, era el infalibilidad en el éxito”. Regular e infalible pero, principal cirujano de la misma, y deseó que su sobre todo, muy precoz. hijo le sucediera en el oficio. Frustrar ese Jean Delay acabó el bachillerato en la rama de destino fue el inicio de una carrera sin filosofía con 14 años, sin sospechar que la precedentes en el panorama de la pregunta sobre las relaciones entre lo físico y lo neuropsiquiatría francesa. moral, en su examen final de disertación filosófica, le iba finalmente a ocupar gran parte de su vida. Gracias a un permiso del ministro de Educación comenzó la carrera de medicina a los 15 años de edad, en París. Posteriormente, fue un amigo de la familia, Pasteur Vallery-Radot, quién tuvo que viajar de París a Bayona para anunciarle al padre de nuestro protagonista que éste jamás será cirujano. A los 20 años estaba ya especializándose en neurología en el hospital de la Pitié-Salpêtrière en el servicio de Lévy- Fig .1: Portada del libro de Delay “Les dissolutions de la Valensi, su primer maestro, para estudiar memoire”. -
From Early Pioneers to Recent Brain Network Findings
Biological Psychiatry: Review CNNI Connectomics in Schizophrenia: From Early Pioneers to Recent Brain Network Findings Guusje Collin, Elise Turk, and Martijn P. van den Heuvel ABSTRACT Schizophrenia has been conceptualized as a brain network disorder. The historical roots of connectomics in schizophrenia go back to the late 19th century, when influential scholars such as Theodor Meynert, Carl Wernicke, Emil Kraepelin, and Eugen Bleuler worked on a theoretical understanding of the multifaceted syndrome that is currently referred to as schizophrenia. Their work contributed to the understanding that symptoms such as psychosis and cognitive disorganization might stem from abnormal integration or dissociation due to disruptions in the brain’s association fibers. As methods to test this hypothesis were long lacking, the claims of these early pioneers remained unsupported by empirical evidence for almost a century. In this review, we revisit and pay tribute to the old masters and, discussing recent findings from the developing field of disease connectomics, we examine how their pioneering hypotheses hold up in light of current evidence. Keywords: Association fibers, Connectomics, Dissociation, History of psychiatry, Integration, Schizophrenia http://dx.doi.org/10.1016/j.bpsc.2016.01.002 The hypothesis that schizophrenia is a disorder of brain connectomics in schizophrenia, Figure 1 shows a selection of connectivity has its roots in the 19th century, in which mental visionary scholars that contributed to the development of the illness was first attributed to the brain [for review, see (1)]. disconnectivity theory of schizophrenia. However, the methodological tools to test the disconnectivity Of note, the nomenclature in psychiatry has changed theory were long lacking, leaving it unsupported by neuro- substantially over the years (7). -
Perspectives in Drug Discovery a Collection of Essays on the History and Development of Pharmaceutical Substances
Perspectives in Drug Discovery A Collection of Essays on the History and Development of Pharmaceutical Substances Professor Alan Wayne Jones Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine Perspectives in Drug Discovery A Collection of Essays on the History and Development of Pharmaceutical Substances Professor Alan Wayne Jones Department of Forensic Genetics and Forensic Toxicology National Board of Forensic Medicine Perspectives in Drug Discovery A Collection of Essays on the History and Development of Pharmaceutical Substances Professor Alan Wayne Jones Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine Artillerigatan 12 • SE-587 58 Linköping • Sweden E-mail: [email protected] Internet: www.rmv.se RMV-report 2010:1 ISSN 1103-7660 Copyright © 2010 National Board of Forensic Medicine and Professor Alan Wayne Jones Design and graphic original: Forma Viva, Linköping • Sweden Printed by Centraltryckeriet, Linköping • Sweden, October 2010 Contents Preface Introduction 1. The First Sedative Hypnotics . 13 2. The Barbiturates ......................... 19 3. The Benzodiazepines ..................... 25 4. Narcotic Analgesics . 31 5. Central Stimulant Amines . 39 6. The First Antidepressants .................. 45 7. Antipsychotic Medication ................. 51 8. Aspirin and Other NSAID .................. 59 9. General Anesthetics . 65 10. SSRI Antidepressants . 71 11. Histamine Antagonists .................... 79 12. Anticonvulsants ......................... 87 -
Autographes & Manuscrits
_25_06_15 AUTOGRAPHES & MANUSCRITS & AUTOGRAPHES Pierre Bergé & associés Société de Ventes Volontaires_agrément n°2002-128 du 04.04.02 Paris 92 avenue d’Iéna 75116 Paris T. +33 (0)1 49 49 90 00 F. +33 (0)1 49 49 90 01 Bruxelles Avenue du Général de Gaulle 47 - 1050 Bruxelles Autographes & Manuscrits T. +32 (0)2 504 80 30 F. +32 (0)2 513 21 65 PARIS - JEUDI 25 juIN 2015 www.pba-auctions.com VENTE AUX ENCHÈRES PUBLIQUES PARIS Pierre Bergé & associés AUTOGRAPHES & MANUSCRITS DATE DE LA VENTE / DATE OF THE AUCTION Jeudi 25 juin 2015 - 13 heures 30 June Thursday 25th 2015 at 1:30 pm LIEU DE VENTE / LOCATION Drouot-Richelieu - Salle 8 9, rue Drouot 75009 Paris EXPOSITION PRIVÉE / PRIVATE VieWinG Sur rendez-vous à la Librairie Les Autographes 45 rue de l’Abbé Grégoire 75006 Paris T. + 33 (0)1 45 48 25 31 EXPOSITIONS PUBLIQUES / PUBlic VieWinG Mercredi 24 juin de 11 heures à 18 heures Jeudi 25 juin de 11 heures à 12 heures June Wednesday 24th from 11:00 am to 6:00 pm June Thursday 25th from 11:00 am to 12:00 pm TÉLÉPHONE PENDANT L’EXPOSITION PUBLIQUE ET LA VENTE T. +33 (0)1 48 00 20 08 CONTACTS POUR LA VENTE Eric Masquelier T. + 33 (0)1 49 49 90 31 - [email protected] Sophie Duvillier T. + 33 (0)1 49 49 90 10 - [email protected] EXPERT POUR LA VENTE Thierry Bodin Syndicat Français des Experts Professionnels en Œuvres d'Art 45 rue de l'Abbé Grégoire, 75006 Paris T. -
History of Psychopharmacology: from Functional Restitution to Functional Enhancement Jean-Gaël Barbara
History of Psychopharmacology: From Functional Restitution to Functional Enhancement Jean-Gaël Barbara To cite this version: Jean-Gaël Barbara. History of Psychopharmacology: From Functional Restitution to Functional Enhancement. Handbook of Neuroethics, 2014. halshs-03090884 HAL Id: halshs-03090884 https://halshs.archives-ouvertes.fr/halshs-03090884 Submitted on 11 Jan 2021 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. HISTORY OF PSYCHOPHARMACOLOGY – FROM FUNCTIONAL RESTITUTION TO FUNCTIONAL ENHANCEMENT Version auteur : J.G. Barbara, 2014. « History of Psychopharmacology: From Functional Restitution to Functional Enhancemen», in Handbook of Neuroethics, Jens Clausen and Neil Levy éds., Dordrecht, Springer, 2014, ISBN 978-94-007-4706-7, p. 489-504. Jean-Gaël Barbara Université Pierre et Marie Curie, CNRS UMR 7102 Université Paris Diderot, CNRS UMR 7219 [email protected] TABLE OF CONTENTS CHAPTER TITLE ABSTRACT 1.0 INTRODUCTION 2.0 FROM ANTIQUITY TO THE 18TH C. 3.0 THE CONCEPT OF PSYCHOPHARMACOLOGY (19TH C.) 3.1 THE RATIONAL REFUSAL OF DRUGS 3.2 NOVEL AND OFTEN NAIVE RATIONALISMS 3.3 NEW DRUGS AND NEW CLINICAL TRIALS 4.0 EXPERIMENTS AND NEWLY SYNTHETIZED DRUGS AT THE TURN OF THE 20TH C. -
History of Sodium Oxybate – a Review
Vol 3 | Issue 2 | 2012 | 104-113. e - ISSN – 2249-7552 Print ISSN – 2229 7502 HISTORY OF SODIUM OXYBATE – A REVIEW I. Govardhan Kumar*, B. Kumar, NS. Midhuna Sagari *Department of Pharmacology, Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupati, Andhra Pradesh – 517 501, India. ABSTRACT Gamma Hydroxybutyric acid (GHB), also known as 4-hydroxybutanoic acid and sodium oxybate is a naturally occurring substance found in the human central nervous system as well as in wine, beef, small citrus fruits, and almost all animals in small amounts. It is also categorized as an illegal drug in many Article countries. It is currently regulated in Australia and New Zealand, Canada, most of Europe and in the US. Key Words: Gamma Hydroxybutyric acid (GHB), 4-hydroxybutanoic acid, Sodium oxybate, History. view INTRODUCTION for the treatment of cataplexy in adult patients Re GHB as the sodium salt, known as with narcolepsy. It is considered to act in a sodium oxybate, is sold by Jazz Pharmaceuticals different way to the only other the licensed under the name Xyrem to treat cataplexy and medication, clomipramine, for this indication. excessive daytime sleepiness in patients with Cataplexy is an abrupt, reversible decrease in narcolepsy. GHB has been used in a medical muscle tone caused by emotion and is reported in setting as a general anesthetic, to treat conditions approximately 75% of patients with narcolepsy. such as insomnia, clinical depression, Sodium oxybate is the sodium salt of narcolepsy, and alcoholism, and to improve gamma hydroxybutyrate (GHB) and is a schedule athletic performance. It is also used as an 4 (part 1 CD Benz) controlled drug in the UK. -
Schizophrenia What Is Psychosis?
Lecture 8 Careful Clinical Observation – chlorpromazine (Thorazine) to aripiprazole (Abilify) Psychosis and Schizophrenia What is Psychosis? • Impaired reality testing - the inability to distinguish between what is real and not real. • Presence of characteristic symptoms: – Disorders of perception (hallucinations) – Disorders of thougg(ht (delusions) – Disorganized speech (disordered associations) – Disorganized or catatonic behavior (rituals) • Note that severe episodes of mood disorders may have psychotic features as secondary symptoms and are not a primary psychotic disorder,,jpp i.e. Major Depressive Episode with pypsychosis or acute mania • Patients with personality disorders (schizotypal, schizoid, borderline and paranoid) can present with psychotic symptoms Psychotic Disorders Primary Psychiatric Disorders • Schizophrenia • Schizophreniform disorder • Schizoaffective disorder • Brief psychotic disorder • Shared ppysychotic disorder • Delusional disorder Schizophrenia • Course of Illness – Onset – Most common initial presentation during adolescence • Imaging studies show this is a period with extensive CNS remodeling – Progression – Patients fall into three general groups • A single psychotic episode followed by good mentlhtal hea lth • A lifelong pattern of remission followed by relapse • Lifelong disease with no remission Schizophrenia Symptoms • Positive syypmptoms (not normally experienced by healthy individuals) – Hallucinations – Delusions – Bizarre behavior • Negative symptoms (normally found in healthy individuals, but not -
Opportunities and Challenges in Psychopharmacology Pierre Schulz, MD
State of the art Opportunities and challenges in psychopharmacology Pierre Schulz, MD This review addresses novel approaches for influencing the transcriptome, the epigenome, the microbiome, the proteome, and the energy metabolome. These innovations help develop psychotropic medications which will directly reach the molecular targets, leading to beneficial effects, and which will be individually adapted to provide more efficacy and less toxicity. The series of advances described here show that these once utopian goals for psychiatric treatment are now real themes of research, indicating that the future path for psychopharmacology might not be as narrow and grim as considered during the last few decades. © 2019, AICH – Servier Group Dialogues Clin Neurosci. 2019;21(2):119-130. doi:10.31887/DCNS.2019.21.2/pschulz Keywords: psychotropic medication; drug development; molecular target Introduction might be an antipsychotic if it inhibited the abnormal stereotypic movements due to (psychosis-inducing) For millennia, humans have swallowed or inhaled amphetamines, and this led him to discover haloperidol, substances with the purpose of putting their psyche in a which did indeed inhibit these movements in rodents. comfortable zone, of adapting their psychological and Henri Laborit, who had studied chlorpromazine (CPZ) to bodily states to avoid suffering, and to regulate, metaphor- dampen neurovegetative responses during anesthesia and ically speaking, their mental engine in a manner suited to surgery, later developed γ-hydroxy butyric acid (GHB, momentary environments and goals. Consumers of psycho- sodium oxybate) in order to augment the brain concen- tropic medications (like those of addictive drugs) maintain tration of γ-aminobutyric acid (GABA), and stimulate this long-standing human tradition and effort.