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Histamine in Psychiatry: Promethazine As a Sedative Anticholinergic
BJPsych Advances (2019), vol. 25, 265–268 doi: 10.1192/bja.2019.21 CLINICAL Histamine in psychiatry: REFLECTION promethazine as a sedative anticholinergic John Cookson (strongly influenced by the ideas of Claude Bernard John Cookson, FRCPsych, FRCP, is SUMMARY and Louis Pasteur). There he met Filomena Nitti, a consultant in general adult psych- iatry for the Royal London Hospital The author reflects on discoveries over the course daughter of a former prime minister of Italy. They of a century concerning histamine as a potent and East London NHS Foundation married in 1938 and she became her husband’slife- chemical signal and neurotransmitter, the develop- Trust. He trained in physiology and long co-worker. They moved in 1947 to the pharmacology at the University of ment of antihistamines, including promethazine, Institute of Health in Rome. In 1957 he was Oxford and he has a career-long and chlorpromazine from a common precursor, interest in psychopharmacology. His and the recognition of a major brain pathway awarded a Nobel Prize for his work in developing duties have included work in psychi- involving histamine. Although chlorpromazine has drugs ‘blocking the effects of certain substances atric intensive care units since 1988. been succeeded by numerous other antipsycho- occurring in the body, especially in its blood vessels He has co-authored two editions of tics, promethazine remains the antihistamine and skeletal muscles’ (Oliverio 1994). He and his Use of Drugs in Psychiatry, published recommended for sedation in acutely disturbed by Gaskell. research student Marianne Staub introduced the Correspondence: Dr John Cookson, patients, largely because it is potently anticholiner- first antihistamine in 1937, developed by altering Tower Hamlets Centre for Mental gic at atropinic muscarinic receptors and therefore the structures of drugs found to block known trans- Health, Mile End Hospital, Bancroft anti-Parkinsonian: this means it is also useful in mitters – acetylcholine and adrenaline – such as atro- Road, London E1 4DG, UK. -
World War II Pilot Frank Welford Kerikeri Music
Erika Grundmann N L. W ZEALAND • (T" I Mansons Landing BC VOP 1KO moneAugust/Septembesr 2000 World War II pilot Frank Welford ISSN 1173-4159 Kerikeri Music Camps Childhood memories - 'Strawberry Fields Forever' Antarctic journey : Robert Falcon Scott 9 "771 173"415007 Images from the regions : Hawke's Bay and Otago jqSism IIB jqj if 3§Bd oj ujttix '9161 u^-ip az^dBj^ 3i[j uo (Mopq SuiSuiMs) uj^qqiQ ^Sjo^^ jo joqs IIOIJOB siqj SuonjdBD joj ^qisuods^j awAi ^JIA^UUBQ ui soipn^s uojjaS^ pjoxejj aqx *^JO^s [Bnsnun UB saDnpojjui qdBjSojoqd jBtisnun uy of rust, lured by the freedom of Australia, he jumped ship in Sydney and set out to seek his fortune in the Blue Mountains. Confident to the point of appearing GERMAN cocky, his motto was "I'm a sailor -1 can do anything!" He worked with the blasting crew in the Lithgow Tunnel construction, and as a waiter at The Hydro Hotel in GEORGE Medlow Bath where he quickly learned English and became known as "George." It was at The Hydro that Erika Grundmann is researching the intriguing he met fellow German Wilhelm Hugo Hildebrandt with character of George Dibbern. In this short whom, in 1910, he travelled to New Zealand. excerpt Erika explores a segment of George's diverse life whilst living in the Hawke's Bay. Hildebrandt, ten years Dibbern's senior and married to Francis Keneally, a young Australian widow with two George Dibbern, as "Business Man," Sydney, 1911 eorge Johann Dibbern was born March 26, 1889 in Kiel, Germany. -
Denman Marine Newsletter
Denman Marine Newsletter Hi, and welcome to the latest Denman Marine newsletter. In this month's newsletter we have; Te Rapunga Restoration Centre Harbour 31 May Special - $150 o all Chesapeake Light Craft Kayak Kits Small Boats Monthly Features the Chester Yawl Customer Build Update Website Additions If there is anything you would like to see in our future newsletters, discuss, query or order, please contact us via the contact form on our website. Te Rapunga Restoration Bruny Island Coastal Retreats and Nature Pact together with the help of some fellow sailing enthusiasts have acquired the boat Te Rapunga. Their goal is to realise Erika Grundmann’s “nostalgic vision” - to fully restore and return Te Rapunga to the Sea - her rightful home. Denman Marine is very proud to be restoring the historic vessel Te Rapunga. Please watch and share the videos below that illustrate the CAD technology being used for the restoration of Te Rapunga, Who is George Dibbern? and the journey of Te Repunga from a suburban backyard in Auckland New Zealand, all the way to our workshop in Kettering Tasmania. Te Rapunga is the foundation for an amazing story about a man, a small boat and the many lives they inuenced along the way. Never heard of George and his boat Te Rapunga? Take a look at Erika Grundman's website which has loads of info on the man and the boat. Better still, buy the books (Quest by George Dibbern and Dark Sun by Erika Grundman) and read about a man who had the courage to follow his heart, regardless of the cost. -
Winter 2008 Volume 22
COMMUNITY AUTHOR #9,000 obody’s counting—except a computer at Simon Fraser University Library—but David Stanley is the 9,000th B.C. author to be added to our encyclopedic, ever- expanding, massive on-line Author Bank for B.C. literature—replete with photos, re- “DAVID views and essays—at www.abcbookworld.com. We’d never heard of NDavid Stanley either, but hey, isn’t that somehow the point? STANLEY, WE Turns out David Stanley once pur- David Stanley has visited more than chased the longest plane ticket ever is- 195 countries and territories. PRESUME.” sued in Canada by Pan American “Each year I try to get to a few Airways back in 1978. He arranged to more countries on my to-do list,” he make over 50 stops between Los Ange- says. “I stay at inexpensive hotels, the les and Singapore. kind I recommend in my guide- Now with nine books to his credit, books. Mostly I prefer to travel in- Stanley has recorded the development cognito, and rough, using public of tourism in the South Pacific over the transport as much as possible.” past quarter-century. Stanley’s “under the radar” approach David Stanley of Nanaimo, seen here on Aitutaki in the Cook Islands, has “In the early days there was only one backfired on him during the papal visit visited more than 195 countries and territories as a travel writer. large resort on Bora Bora,” he recalls, of John Paul II to the Solomon Is- “and it was fine to camp free, for as long lands in 1984. -
PIRATES of BOAT HARBOUR -DESTINATION: WEST COAST July 1999-$ 4.50 Acific
PIRATES Of BOAT HARBOUR -DESTINATION: WEST COAST July 1999-$ 4.50 acific I X i ML; 17™' 78624" 70129"" 9" HISTORY By Erika Grundmann George Dibbern: Sailor-Philosopher A free-spirited wanderer who declared himself beyond nationality, Qeorge Dibbern spent two years on the B.C. coast, writing, cruising, and inspiring all he met with his idealism and charisma. Left: George Dibbern sailed the 32' ketch Te Rapunga from his native Germany to New Zealand, then to B.C. and back to New Zealand. She is pictured at the start of the 1934 Trans Tasman Race, which she won. Below: Dibbern aboard Te Rapunga at Immigration Wharf, Vancouver, in 1937. HEY hove to in the early morning mist. After 31 days en route from Honolulu, a clean-up was in order for boat and Tcrew. Te Rapunga had once again made landfall, this time in Victoria. Canada at last! Skipper George Dibbern, along with Roy Murdock and Eileen Morris, had started their adventure in Auckland, New Zealand almost two years earlier. The brass polished and the crew, like the deck, scrubbed, the 32' ketch sailed (no motor for this lot!) confidently into Vic- toria Harbour. Puzzled by the fact that no harbour boat came to meet them, they circled, then tied up at Enterprise Wharf, only to learn that they would have to return to William Head for pratique. It was July 1, 1937. By late afternoon, with proper clearance, Te Rapunga lay silent alongside Enterprise Wharf. Her crew had been whisked off to the hospitality of the Royal Victoria YC. -
Toxicol Rev 2004; 23 (1): 21-31 GHB SYMPOSIUM 1176-2551/04/0001-0021/$31.00/0
Toxicol Rev 2004; 23 (1): 21-31 GHB SYMPOSIUM 1176-2551/04/0001-0021/$31.00/0 2004 Adis Data Information BV. All rights reserved. γ-Butyrolactone and 1,4-Butanediol Abused Analogues of γ-Hydroxybutyrate Robert B. Palmer1,2 1 Toxicology Associates, Prof LLC, Denver, Colorado, USA 2 Rocky Mountain Poison & Drug Center, Denver, Colorado, USA Contents Abstract ................................................................................................................21 1. Clinical Effects .......................................................................................................23 2. Diagnosis and Management ..........................................................................................25 3. Withdrawal ..........................................................................................................26 4. Conclusion ..........................................................................................................29 Abstract γ-Hydroxybutyrate (GHB) is a GABA-active CNS depressant, commonly used as a drug of abuse. In the early 1990s, the US Drug Enforcement Administration (DEA) warned against the use of GHB and restricted its sale. This diminished availability of GHB caused a shift toward GHB analogues such as γ-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) as precursors and surrogates. Both GBL and 1,4-BD are metabolically converted to GHB. Furthermore, GBL is commonly used as a starting material for chemical conversion to GHB. As such, the clinical presentation and management of GBL and 1,4-BD -
Autograph Auction Saturday 14 December 2013 11:00
Autograph Auction Saturday 14 December 2013 11:00 International Autograph Auctions (IAA) Radisson Edwardian Heathrow Hotel 140 Bath Road Heathrow UB3 5AW International Autograph Auctions (IAA) (Autograph Auction) Catalogue - Downloaded from UKAuctioneers.com Lot: 1 Lot: 4 GULLY JOHN: (1783-1863) CARNERA PRIMO: (1906-1967) English Boxer, Sportsman and Italian Boxer, World Heavyweight Politician. Signed Free Front Champion 1933-34. Bold blue envelope panel, addressed in his fountain pen ink signature ('Primo hand to Thomas Clift at the Carnera') on a page removed Magpie & Stumps, Fetter Lane, from an autograph album. One London and dated Pontefract, very slight smudge at the very 27th September 1835 in his conclusion of the signature and hand. Signed ('J Gully') in the some slight show through from lower left corner. Very slightly the signature to the verso. VG irregularly neatly trimmed and Estimate: £60.00 - £80.00 with light age wear, G. The Magpie & Stumps public house is situated opposite the Old Bailey Lot: 5 and was famous for serving BOXING: Small selection of execution breakfasts up until vintage signed postcard 1868 when mass public hangings photographs by the boxers Gene were stopped. Tunney (World Heavyweight Estimate: £80.00 - £100.00 Champion 1926-28), Max Baer (World Heavyweight Champion 1934-35) and Ken Overlin (World Lot: 2 Middleweight Champion 1940-41; WILLARD JESS: (1881-1968) signed to verso). Each of the American World Heavyweight images depict the subjects in full Boxing Champion 1915-19. Blue length boxing poses and all are fountain pen ink signature ('Yours signed in fountain pen inks. truly, Jess Willard') on a slim Some slight corner creasing, G to oblong 8vo piece. -
From Early Pioneers to Recent Brain Network Findings
Biological Psychiatry: Review CNNI Connectomics in Schizophrenia: From Early Pioneers to Recent Brain Network Findings Guusje Collin, Elise Turk, and Martijn P. van den Heuvel ABSTRACT Schizophrenia has been conceptualized as a brain network disorder. The historical roots of connectomics in schizophrenia go back to the late 19th century, when influential scholars such as Theodor Meynert, Carl Wernicke, Emil Kraepelin, and Eugen Bleuler worked on a theoretical understanding of the multifaceted syndrome that is currently referred to as schizophrenia. Their work contributed to the understanding that symptoms such as psychosis and cognitive disorganization might stem from abnormal integration or dissociation due to disruptions in the brain’s association fibers. As methods to test this hypothesis were long lacking, the claims of these early pioneers remained unsupported by empirical evidence for almost a century. In this review, we revisit and pay tribute to the old masters and, discussing recent findings from the developing field of disease connectomics, we examine how their pioneering hypotheses hold up in light of current evidence. Keywords: Association fibers, Connectomics, Dissociation, History of psychiatry, Integration, Schizophrenia http://dx.doi.org/10.1016/j.bpsc.2016.01.002 The hypothesis that schizophrenia is a disorder of brain connectomics in schizophrenia, Figure 1 shows a selection of connectivity has its roots in the 19th century, in which mental visionary scholars that contributed to the development of the illness was first attributed to the brain [for review, see (1)]. disconnectivity theory of schizophrenia. However, the methodological tools to test the disconnectivity Of note, the nomenclature in psychiatry has changed theory were long lacking, leaving it unsupported by neuro- substantially over the years (7). -
Abon Waywan Rm
BOOKS edited by Margie Thomson DARK SUN: TE RAPUNGA AND THE QUEST OF GEORGE DiBBERN By Erika Grundman David Ling, $49.99 Reviewed by Margie Thomson EORGE DIBBERN, vagabond, adven- turer. Never a member of any herd, Ghe was the original "citizen of the world", who sailed the seven seas with his own flag, his own passport, and an extraor- dinary, free-thinking philosophy that made him friends and admirers (and surprisingly few detractors) in every port. Born in Germany in 1889, Dibbern first went to sea at 18 as a cabin boy aboard a merchant sailing ship, but soon realised that, CAREFREE: George with engines about to supersede sail, it would Dibbern lived his life no longer be a desirable career. Sail was according to his always the thing for Dibbern. conscience He jumped ship in Australia and eventually made his way to New Zealand, which he loved, but where he was interned on Somes Island during World War I. Sent back, against his will, to Germany in 1919, he stayed 10 years, marrying, fathering three daughters, struggling hopelessly against abon Germany's crippling economic problems and huge unemployment. Finally, in 1930, he took off in a 9.75m ketch for freedom and a life unbound by convention. waywan rm For the next 30 years he sailed the world, apart from another period of internment on Somes Island during World War II, despite his down a job and lived frugally, making ends wife and family he left in Germany. visible and vocal rejection of Nazism. Had he meet by writing, lecturing and the generosity Certainly, this issue hangs like a black returned to Germany, he would, his wife of others. -
Psychiatry and Stigmatization
EDITOR’S NOTE Psychiatry and Stigmatization Amir Zarrinpar Editor WHEN MURRAY AND LOPEZ IN 1996 INTRODUCED THE IDEA OF THE DIS- Stuart P. Weisberg ability-adjusted life-year (which measures healthy years lost to pre- Columbia University College of Physicians mature mortality or disability), it should have come as no surprise when and Surgeons they found that 7 of the top 10 causes of disability in industrialized Deputy Editors countries were mental disorders. Unipolar major depression and al- Alison J. Huang, MPhil University of California ON THE COVER cohol abuse, the top 2 on this list, caused more years lost to disability San Francisco Christopher Adams, 1 School of Medicine Columbia University, than the next 5 combined. Pam Rajendran College of Physicians The public remains reluctant, however, to respond to this public Boston University and Surgeons, School of Medicine health problem. A 1996 poll found that most people would be un- Tripods, white Associate Editors willing to support paying for mental illness treatment if it would lead stoneware, low-fire 2 Rahul Rajkumar underglaze, 22.8 ϫ to increases in their premiums or taxes. Legislators appear similarly Yale University ϫ School of Medicine 22.8 22.8 cm. reluctant to support measures that would make mental health care more Teri A. Reynolds, PhD accessible. In his report on mental health, the US surgeon general urged University of California San Francisco proper public education to remove the misperceptions and stigma of School of Medicine mental illnesses that prevent them from being treated like other types John F. Staropoli of medical illness.3 This task will likely prove difficult as mental ill- Columbia University College of Physicians nesses have suffered from misperception and stigma ever since and Surgeons ancient times. -
Perspectives in Drug Discovery a Collection of Essays on the History and Development of Pharmaceutical Substances
Perspectives in Drug Discovery A Collection of Essays on the History and Development of Pharmaceutical Substances Professor Alan Wayne Jones Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine Perspectives in Drug Discovery A Collection of Essays on the History and Development of Pharmaceutical Substances Professor Alan Wayne Jones Department of Forensic Genetics and Forensic Toxicology National Board of Forensic Medicine Perspectives in Drug Discovery A Collection of Essays on the History and Development of Pharmaceutical Substances Professor Alan Wayne Jones Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine Artillerigatan 12 • SE-587 58 Linköping • Sweden E-mail: [email protected] Internet: www.rmv.se RMV-report 2010:1 ISSN 1103-7660 Copyright © 2010 National Board of Forensic Medicine and Professor Alan Wayne Jones Design and graphic original: Forma Viva, Linköping • Sweden Printed by Centraltryckeriet, Linköping • Sweden, October 2010 Contents Preface Introduction 1. The First Sedative Hypnotics . 13 2. The Barbiturates ......................... 19 3. The Benzodiazepines ..................... 25 4. Narcotic Analgesics . 31 5. Central Stimulant Amines . 39 6. The First Antidepressants .................. 45 7. Antipsychotic Medication ................. 51 8. Aspirin and Other NSAID .................. 59 9. General Anesthetics . 65 10. SSRI Antidepressants . 71 11. Histamine Antagonists .................... 79 12. Anticonvulsants ......................... 87 -
History of Psychopharmacology: from Functional Restitution to Functional Enhancement Jean-Gaël Barbara
History of Psychopharmacology: From Functional Restitution to Functional Enhancement Jean-Gaël Barbara To cite this version: Jean-Gaël Barbara. History of Psychopharmacology: From Functional Restitution to Functional Enhancement. Handbook of Neuroethics, 2014. halshs-03090884 HAL Id: halshs-03090884 https://halshs.archives-ouvertes.fr/halshs-03090884 Submitted on 11 Jan 2021 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. HISTORY OF PSYCHOPHARMACOLOGY – FROM FUNCTIONAL RESTITUTION TO FUNCTIONAL ENHANCEMENT Version auteur : J.G. Barbara, 2014. « History of Psychopharmacology: From Functional Restitution to Functional Enhancemen», in Handbook of Neuroethics, Jens Clausen and Neil Levy éds., Dordrecht, Springer, 2014, ISBN 978-94-007-4706-7, p. 489-504. Jean-Gaël Barbara Université Pierre et Marie Curie, CNRS UMR 7102 Université Paris Diderot, CNRS UMR 7219 [email protected] TABLE OF CONTENTS CHAPTER TITLE ABSTRACT 1.0 INTRODUCTION 2.0 FROM ANTIQUITY TO THE 18TH C. 3.0 THE CONCEPT OF PSYCHOPHARMACOLOGY (19TH C.) 3.1 THE RATIONAL REFUSAL OF DRUGS 3.2 NOVEL AND OFTEN NAIVE RATIONALISMS 3.3 NEW DRUGS AND NEW CLINICAL TRIALS 4.0 EXPERIMENTS AND NEWLY SYNTHETIZED DRUGS AT THE TURN OF THE 20TH C.