2010 Annual Report RESEARCH OUTREACH ADVOCACY 3 Hepat itis B Foundation “We appreciate [the HBF’s] continued support of the Hep B community. With the addition of a second adopted child

DearThe Hepatitis Friends, B Foundation has enjoyed one of its most with hep B into our family, we obviously 2010 Annual Report productive years despite the economic downturn. We are are supportive of your efforts in pleased to report that our work has been a bright spot in RESEARCH research and education.” one of the toughest years. YEAR IN REVIEW () This year we have focused our efforts on making the Financial Information* greatest impact on some of the greatest unmet needs. (Fiscal Year 2010 ending June 30, 2010) IN THE LABS This includes establishing consensus recommendations Sources of Funds – HBF & IHVR Combined for hepatitis B screening and treatment of children who (Total $4,322,068) live with this disease and for primary care providers who Charitable lack clear guidelines. Grants 84% Contributions 11% $3,649,257 $475,492 Research results take longer, but we have impressive Interest >1% LIVING SCIENCE and tangible results to share, too. This year, the $3,157 Building for a Cure cancer biomarker that we helped to discover has been Other 4% $194,162 HBF’s groundbreaking for the expansion optioned to a major diagnostics company. If all goes well, of its research facility to build nine new this blood test will be available for human use within the labs, which includes a teaching lab, • Biomarkers of liver cancer enter next couple of years. represented a bright spot during a tough advanced option development with So, if this is what we can accomplish in a tough year, economy. Funding for the $1.4 million Abbott Diagnostics (Block et al) • New pathway of HBV DNA synthesis it has only got to become easier! Thanks to all of you for renovation project was provided in part • Biomarkers of liver fibrosis are good discovered (Guo et al, Journal of Virology 2009) your continued support, donations and confidence by the HBF and its research organization, enough to advance to testing in 15,000 in our mission. the Institute for Hepatitis and Virus people with Johns Hopkins University • New drug (alkylated porphoryn) Research, and Univest. in an NIH-funded study discovered that inactivates HBV, HCV, & (Mehta et al, in progress) HIV without harming mammalian cells Sincerely, Uses of Funds – HBF & IHVR Combined (Guo et al, submitted 2010) (Total $4,028,054) • Primabody, marker of infectious disease, validated in animal studies • Glucovir drug enhances immune attack Timothy M. Block, Ph.D. Outreach and (Chen/Romano et al, in preparation) against hepatitis B in woodchucks President and Co-Founder Research 56% Education 21% $2,222,270 $834,920 (Norton et al, Hepatology 2010) • Liver carcinoid drug successfully completes Phase II human studies • Liver cancer drug to be tested in animals (Shailubhai et al, in progress with Callisto, Inc.) (Cuconati et al, in progress) Public Health 4% Joel D. Rosen, Esq. $188,538 • Urine DNA test for colorectal cancer and • New glucovir compound protects animals Chairman of the Board polyps and liver cancer gets major award from Dengue disease Supporting Services 5% PA state senator Chuck McIlhinney (3rd from from the Coulter Foundation (Su et al) (Chang et al, submitted 2010) $210,400 right) and PA Congressman Patrick Murphy (2nd to right) and PA state representatives • Human gene products discovered that • Serum micro arrays can represent 8,000 Marguerite Quinn (center) and Kathy Watson repress hepatitis B, C and other viruses different people on a single small “chip” General and (Guo et al, Journal of Virology 2009) (Chen et al, in progress) Administrative 14% (right) joined HBF to lend their support at $571,926 our groundbreaking ceremony at the PA Center (Jan 2010). HBF manages HBF’s research is conducted in partnership with Drexel University College of Medicine, and co-owns the Center, which it created in whose labs are located at our Biotech Center. * This audited financial information includes revenue and expenses from HBF and its 2006 to accelerate its research mission. research institute IHVR, but excludes the Foundation’s 50% ownership (or $6.9 million) in the PA Biotechnology Center valued at $13.8 million as per audited statements. 4 5 Hepat Board of Directors Biotechnology Faculty

State Recognition for HBF Research International HBV Meeting 2009 Bruce Witte Lecturer 2010 Chairman William Kinney, PhD itis B Foundation Joel Rosen, Esq. Mohan Philip, PhD, MBA

In a special HBF coordinates this prestigious international scientific President Adjunct Research Faculty ceremony at the meeting each year that attracts hundreds of researchers from Timothy Block, PhD These Drexel U. research faculty members state Capital, around the world to work at our research center and are

Vice President supported in part by HBF/IVHR funds 2010 Annual Report PA Governor discuss the science W. Thomas London, MD Jinhong Chang, MD, PhD Ed Rendell of hepatitis B and Treasurer Mary Ann Communale, MS announced new D viruses. This R. Donald Leedy, MBA Yanming Du, PhD Alison Evans, ScD grant awards year the meeting Secretary Haitao Guo, PhD to support was held in the Janine Witte Ju-Tao Guo, MD the important work of research groups that included the beautiful Loire Dr. T. Jake Liang (left), from the National Joan M. Block, RN, BSN Xuanyong Lu, PhD Anand Mehta, D.Phil HBF and its research institute – the Institute for Hepatitis Valley in France. Institutes of Health, gave the 9th Annual Thomas Block Stanley Broadbent Tulin Morcol, PhD and Virus Research (IHVR) – which is led by HBF/IHVR Bruce Witte Lecture about “Choreographing 2009 Meeting co-chairs Dr. Camille Sureau (France) and Alan Brownstein, MPH Brad Nefsky, PhD president Dr. Timothy Block (far left). (June 2010) Dr. Stephen Locarnini (Australia) model the unique HBV ties the Tango between Hepatitis C Virus and Cells Sandra Budinsky Pamela Norton, PhD given by HBF at the concluding banquet dinner. (Oct. 2009) by Functional Genomic Screen.” The lecture James Datin Allen Reitz, PhD Ying-Hsiu Su, PhD series was established by HBF co-founders Kimberly Jungkind, RN, MPH Dale Kindregan Executive Director Paul and Janine Witte. (April 2010) Charles Sigety, Esq. Joan M. Block, RN, BSN Gurney Sloan, Esq. Catharine Williams, MGA Chief Business Officer HBF Distinguished Scientist Robert Zivin, PhD Nelson Carvalho, MBA Director of Programs Award 2010 Medical and Scientific Advisors Margaret Farley, MBA TRAINING YOUNG SCIENTISTS Harvey Alter, MD Timothy Block, PhD Director of Accounting Summer College Research The High School Enrichment Baruch Blumberg, MD, PhD Patti McAloon, MBA Internships provide a wonderful (and Program offers a two-week “hands-on” Carol Brosgart, MD Director of Operations/IT Nathaniel Brown, MD paid) opportunity for students to work experience in a professional lab for Konrad Kroszner Raymond Dwek, D Phil, FRS on an independent research project with students entering their senior year. Lawrence Friedman, MD Outreach and Public Health senior scientists for a 10-week period. Interactive seminars led by leaders in the Robert Gish, MD Nina Baltierra Funding is provided by grants from field introduce them to careers in science, Hie-Won L. Hann, MD Gang Chen, MD, PhD W. Thomas London, MD Chari Cohen, MPH (DrPh candidate) the PA Department of Health, Merck’s medicine, patent law, public health and “Working as a young scientist William Mason, PhD Jackie Corwell West Point Charitable Contributions more. This program is supported in part Dr. R. Palmer Beasley (center), Brian McMahon, MD Richard Kahn, MPH is a unique experience. Many Kenneth Rothstein, MD Kelly La (MPH candidate) Committee, and the Charles Sigety by EITC funds received from accompanied by his wife and research doors of opportunity have Family Foundation. Universal Health Services of Delaware Raymond Schinazi, PhD Loretta Molle collaborator Dr. Lu Yu Wang, received the Bud Tennant, DVM Lauren Nonini opened for me and to others and Wal-Mart Stores, Inc. Distinguished Scientist Award from HBF like me in the [HBF labs]. We are president Dr. Timothy Block (left) and Senior Research Faculty The Apprenticeship Program is Songming Chen, PhD encouraged to be unafraid in Nobel Laureate Dr. Baruch Blumberg designed for the recent college graduate who Andrea Cuconati, PhD our insights, and to realize that (right) at the Crystal Ball for his seminal HBV Surendra Dheer, PhD wants to gain real-life research experience every new discovery comes research conducted in Taiwan that identified Sergey Ilyin, PhD before making a decision to pursue graduate Ramila Philip, PhD mother-to-newborn transmission and the from both standing on the or medical education. They receive valuable David Ren, MD, PhD fatal link to primary liver cancer. He served shoulders of giants and from mentorship and encouragement to become Patrick Romano, PhD as Chair of the National Academies Institute Thomas Russell, PhD pioneering new ideas.” deeply involved in their research projects Kunwar Shailubhai, PhD, MBA of Medicine (IOM) committee that published Anne Lamontagne, former Research and to participate in the intellectual world James Thacker, PhD in January 2010 the first IOM report on Apprentice now in graduate school. of scientists through research rounds, Michael Xu, PhD “Hepatitis and Liver Cancer”. (April 2010) journal clubs, and special seminars. 6 7 Hepat “Your website has been an

Drug Discovery itis B Foundation CALENDAR YEAR 2009 DONATIONS invaluable tool for my family, and Takes Center Stage Thank you to all of the individuals and organizations that have we thank you for helping us in our treatment of the disease.” generously supported the Hepatitis B Foundation. We truly appreciate HBF established this year the PA Center for Drug Discovery (PCDD) as an innovative (California)

everyone who has contributed to advancing our Cause for a Cure! program of its research institute, the Institute 2010 Annual Report for Hepatitis and Virus Research, to accelerate OUTREACH BENEFACTORS’ SOCIETY President’s Circle — $1,000 - $2,499 the translation of biomedical discoveries into $1000 – $10,000 and more AIG Matching Grants Program therapies for clinical evaluation in humans. IN THE COMMUNITY Amper, Politziner & Mattia, LLP Our PCDD program encompasses activities Bank of America United Way Campaign to improve efficiencies in early drug discovery Visionary Circle Begley, Carlin & Mandio, LLP research and to help integrate senior scientists $10,000 and more Stanley and Gerri Broadbent Hepatitis B Faith Calhoun back into the workforce who have been laid-off Gunst Charitable Trust Delaware Valley College from companies that have downsized during The Philadelphia Story Kahn Charitable Foundation Discovery Chicago the tough economy (we call this our “Up and The hepatitis B virus was discovered by Universal Health Services of Delaware Drexel University College of Medicine On June 15, 2010, HBF launched Esterly Family of The Pittsburgh Out” program which has been well-received). Hep B Free Philadelphia, a public health HBF’s Distinguished Scholar Dr. Baruch Foundation campaign based on the successful model Blumberg (for which he won the Nobel Global Circle Fox Rothschild, LLP B Informed Now! in San Francisco. Hep B Free aims to Prize) at Fox Chase Cancer Center in Glenmede Trust Company $5,000 - $9,999 Breaks the Barriers Philadelphia, and he invented the hepatitis Matt and Anne Greene increase screening Timothy and Joan Block Hawai’i Community Foundation HBF revamped its annual patient conference and vaccination rates B vaccine that is now manufactured by Joseph Potz and Pam Norton Making the Rounds Grace John into a mobile event that touched down on through a citywide two companies located in the region. The Charles Reynolds and Katharine Holloway R. Donald and Martha Leedy mobilization effort. first animal discovered to be most useful HBF continues to make an impact on Tulchin Family Foundation Robert Loughery both U.S. coasts in Philadelphia and Los Anand and Valerie Mehta Angeles, with Seattle, WA slated to round HBF’s campaign also in studying hepatitis B was an infected clinical practice through its specialty Microsoft Giving Campaign out the 2010 itinerary. The B Informed Now! returns hepatitis B to groundhog living at the Philadelphia Zoo. workshops. The pediatric HBV Founders’ Circle Pharmabridge Patient Workshops on hepatitis B and liver the forefront in Philadelphia, which has And the only national nonprofit dedicated workshops we convened to focus on $2,500 - $4,900 Plumbline Construction been at the center of the hepatitis B story to this disease, the Hepatitis B Foundation, children has resulted in the first national Quakertown National Bank cancer attracted almost 200 people at each Bugajewski Facility Services Joel and Nancy Rosen site and offered free HBV screenings as well. from the very beginning. was established in Philadelphia as well. recommendations for their care and CCG Metamedia Claire Signs Featured keynote speakers included Drs. treatment; and this year’s workshop with High Swartz, LLP Bud Tennant Emmett Keeffe (Stanford U), Hie-Won leading primary care providers (PCPs) W. Thomas and Linda London University City Science Center established recommendations for hepatitis Research Triangle Institute University of the Sciences Hann (Thomas Jefferson U), andKenneth Univest Richard Slabinski Rothstein (Drexel U). Sessions were offered B in busy primary care settings. All of the Wal-Mart Stores, Inc. Brian Wigdahl in English with headsets provided for live HBF clinical workshops were facilitated Kyan Win translations into Chinese and Korean. Podcasts by HBF medical advisors Drs. Brian Paul and Janine Witte McMahon and Thomas London. Worth & Company of the workshops are now available in all three languages on our website @ www.hepb.org.

“I would love to be able to Twitter A Social (Networking) Butterfly @hepbfoundation contribute millions if I could! Your HBF has entered the dawn of a new era where organization has been a huge help to Facebook: technology and human connections have been www.facebook.com/hepbfoundation me and my family and I have taken blended to create the ultimate interactive the B-Informed newsletter with me YouTube: experience — Social Media Networking. We are www.youtube.com/hepbfoundation to doctor’s visits to make sure he joining the global conversation, so please log on to had the most current information.” Linkedin: our new social media venues to keep in touch! www.linkedin.com/companies/hepatitis-b-foundation (Maine) 8 9 Hepat CALENDAR YEAR 2009 DONATIONS (continued) “Our daughter was adopted from

China and most likely infected itis B Foundation Ambassadors’ Circle — $500 - $999 Steve and Janet Cohen at birth. Your work to increase Amgen Foundation Matching Gifts Bertha Conyers Victor Araya CP Commercial Printing ADVOCACY awareness of HBV will surely lead Artemis Solutions Andy Cuconati to more extensive research, and

Chistopher and Catherine Asplen Joshua and Miriam Feldstein —I pray—an eventual cure. 2010 Annual Report Clement and Choi Seung Au Fox Chase Cancer Center Bricker, Landis & Hunsberger, LLP Jamie Fox ON THE HILL Thank you.” Bridgepoint Insurance Group Robert Frey (Minnesota) Bronx Park Assets Curt and Roseanne Friehs 5 Million Americans Alan and Patti Brownstein Gregory Gore Brian and Annie Buinewicz Thomas Grim Silent No More! Scott and Sandy Budinsky Henry “Dutch” and Kim Gronendahl HBF helped to organize the first World Andrew and Kathy Chen Caitlyn Hoang th Michael Christenson Peter and Judith Hoekstra Hepatitis Day Rally on May 19 in Washington, John Donahue Wilson Hong DC with the National Viral Hepatitis Roundtable Enantigen Therapeutics Joyce Huber which sponsored the event. More than 50 HBF Alan and Irma Freedman Patrick Hylton researchers, outreach staff and board members James Horan Scott Jacobs Joanne Jensen John Jennings traveled to the Capitol to advocate for increased Emmet Keeffe Donald and Kimberly Jungkind federal attention and funding for chronic hepatitis. Dale Kindregan Patrick and Cynthia Kelly With more than 5 million Americans living with Anthony Klockenbrink Martin Kimmel hepatitis B and C, we cannot be silent anymore. Richard Chung-Wen Liu Izabel Lam Arline Loh Peter Lamberts Medical Diagnostic Laboratories Raymond Lee James Mongold Robert Leventhal Janice Morris Madison Associates Deborah Nelson Marketri Paul Nelson Patrick Marra Prodesco Mercer Communications Yusheng Qu Jean Miller Virginia Shames Tulin Morcol Landmark IOM Report on HBF Joins Historic New Beth Snyder Catherine Ng Hepatitis and Liver Cancer Asia Pacific Coalition David Tolle Timothy Peissig Elizabeth Walsh Thomas Quirk, Jr. HBF is proud to have been a key HBF co-founders Timothy and Joan Block Lindsey Wayne and Eva Hogg Congressman Mike Honda sounds the David Rolf participant in the Institute of Medicine (standing, center) were invited to present U.S. advocacy John Wu and Kimberly Harper The Sawtooth Group alarm at the World Hepatitis Day rally. Richard Sokorai (IOM) study that looked at the U.S. successes at a workshop in Beijing to discuss better Discovery Circle — $250 - $499 Susan Stellini response to chronic viral hepatitis. The policy coordination for hepatitis B in the Asia Pacific. Susannah Amiteye Eric Stollnitz landmark IOM report on Hepatitis and The workshop included leading clinicians in the region Baldwin Publishing Ying-Hsiu Su Liver Cancer concluded that, “The current and other international groups. Discussions revolved Bee Bergvall and Company Sun Microsystems Foundation Richard Bendis James Talamonti approach to the prevention and control of around the need to identify public policy issues that Joanne Blasenheim Dan and Cindy Taylor chronic hepatitis B and hepatitis C is not impede optimized screening and linkage to care, and Joyce Block David Thompson working” and that “inadequate resources to develop practical strategies to reduce the burden Sarah Williams Boa Construction are being allocated” to address the needs of hepatitis B. At the conclusion of the workshop the Mary Boatner George and Cathleen Woods Bucks County Community College Mary Yee of 5 million affected Americans. The IOM decision was made to establish a new independent, P. (Peter) Chiang committee met over an 18-month period and included two HBF multi-disciplinary group — Coalition for Eradication of Paul and Chari Cohen PA Congressman Patrick Murphy stands with the HBF scientific advisers —Drs. Harvey Alter and Brian McMahon — Viral Hepatitis in Asia Pacific (CEVHAP) — and HBF is at the historic World Hepatitis Day rally in Washington, DC. and HBF director of Public Health Research Dr. Alison Evans. proud to be a charter member. 11 Hepat itis B Foundation CALENDAR YEAR 2009 DONATIONS (continued) CALENDAR YEAR 2009 DONATIONS (continued)

Outreach Circle — $100 - $249 Jun Iwata Harriet Stenzel Kathy Crissey Frank Liu Andy Tien Matthew Adlai-gail Sherry Jean Herbert and Joan Stevens Brian Dang Lan Liu Nancy Tolle Barbara Allar Bonnie Jung Frederick Stiff Raymond D’Auria Mei Mei Ma Harry Tse and Zinna Lee

Margaret Keenan Linhui Sui R. Kimber and Christine David Thomas and Lori Macisaac Hin Wing Tse

Debra Andrews 2010 Annual Report Michael and Iris Artaki Alan Keim Judy Tam Angelo DeMeo Jeffrey Markowitz Heng Fu Tseng Artisans Gallery Robert Kelley Joly Tang Massimo and Mariachristina Di Blasio Tulaga Masaniai United Way California Capital Region Richard Bader Dan Kilcup John Taylor Se Jong Ding Candice Vargas McAuliffe Employees Campaign Eileen Beck KT Foundation Titan Mobile Shredding Paul Dominguez Don McGee Ron Uroda Susan Bellaire Albert Ku Thomas and Jessica Truong William and Patricia Donaldson Patrick and Maureen Cronin-McLaughlin Deb Watkins Patricia Benham Shailesh Kulkarsh Eva Tsai John and Sandra Draus Reggie and Neema Chong Michaud Carrie Welch Brant Biehn Michael and Jan Landis Walter Tsou Diane Ellis-Marseglia Robert Mickle, Jr. Vanessa Wenzell Earl Bierman John and Barbara Leavy C. Theodore Tucker Employment & Community Options Caroline Minnerick Lt. Roy Williams Bob Bowman Rachel Lefkowitz Uptowne Deli & Pizzeria Linda Essary Edith Mock Catherine Wolfe Matt Buchwitz Kathy Licht Sharon Victor John Estok Carlo Momo Robert Woo Jose Mari Casas Jun Luo Kathleen Watson Rich and Terri Ferraro Leslie Moore Lixun Zhang Garrett Chang Scott and Daryl MacKeverican Michael Wehner Kenneth and Anne Fields Morgan Stanley Zhong Zheng Gang Chen Shing-Wen Mao Wells Fargo Community Support Edward Fischer Louis Muzekari Amy Zipp Francis and Linda Chisari Gerard Marini Campaign Frank and Glenna Follmer Ulviyya Nasibova Marc and Ann Clearfield Donna Mattox Dietmar and Mary Lou Weselin Brian Free Network for Good Joe and Molli Conti Patti McAloon Deborah Wexler Thomas Freeman Thuan Nguyen Margaret Copeland Jim McGowan Thomas Wight Susan Gabai Peter Nguyen Alioune Coulibaly Brian McMahon Nicholas and Monica Winter Kathleen Garcia Mark Obermann David Crane Ed Meyers Stephen Wong Inge Green John Oldani Suzanne Crilley Patti Monaco Ben Woods Cindy Gutowski Shannon O’Neill James and Carol Curry Joanne Moroney Alan Chung-I Yu Richard and Renee Haliburton Tsung Hsi Oulee Loren Danzis Richard Moyer Greg Zappin Eric and Elizabeth Cohen Hamblet Mike and Meg Ovitt David and Doris Dowdy John Nardini Edward Zekas Glenn Hammond St. Thomas Parish Tom Drakeford Clyde and Mable Ng Mingyu Zhu Hunt Hawkins Pfizer United Way Campaign John and Joann Nonini Marc Helman Rose Poponi Patricia Dunn CORPORATE AND FOUNDATION Gregory Farkas Lauren Nonini Awareness Circle — Up to $99 Hollenbach Family Kristine Powell Eric and Elizabeth Friedman Eleanor Orth Ishola Adeyemo Max Holt David Provenzano GRANTS Lawrence Friedman Edward Peritz Steve Alexander Alfred and Evelyn How Michelle Pugh AAPCHO Roger and Nancy Gallic Janet Perper Danna Arnold Becky Hubbell John and Sandra Quirinale Bayer GE Foundation Pina’s Pizza of Chalfont Earlene Austin Kevin Hull Bob and Jackie Radenbaugh Bristol-Myers Squibb Genentech Givingstation Prudential Foundation Matching Gifts Bank of America Matching Gifts Steven and Jo Ann Hurley Wen X. Zeng Raiti Gilead Sciences Robert Gish Joohyun Pyune Laurie Beckert Sam Hurwitz Florence Render GlaxoSmithKline Give With Liberty Campaign Xiangdong (David) Ren Jackie Benson Suzanne Jeakle Charles and Lorie Roth Idenix GoodSearch Carol Rico Priscilla Bizer JP Morgan Chase Employee Giving Matthew Schneider Johnson & Johnson Mary Goudreault Richard and Priscilla Rosenberger Geraldine Block Barry and Yoli Kahn Larry Schneiderman Merck & Co. William Green Kenneth and Maria Rothstein Paul Burton Nina Katz Dennis Schuster Merck West Point Charitable David and Cynthia Gruber Bill Royal Joyce Cain Kathleen Kerrigan Yeh-Heng Sheng Contributions Committee Ziying Han Russell Biotech Su Cartmell Barbara Kilgallon Robert and Mary Sheppard Novartis Richard and Hie-Won Hann Tom Russell Everett and Diana Chambers Fawn King Robert Shore Onyx Dorothy Harris Kathleen Russo Daniel Champagne Sherrin Krueger Sara Shupe Vertex Pharmaceuticals Carol Hart James Ryan Ka-Ming Chan Denise Kunkel I. Earl and Janet Nancy Simon Anne Heacock James Samuels Yeuk “Atom” Chan Robert and Cheryl Lagay Priscilla Smith FEDERAL AND STATE GRANTS Harry and Dorothy Hellerman Ronald and Joyce Sanderson Joseph Chan Linda Landy Terry Spencer National Institutes of Health Harry Hicks Marlene Schaps Chun Chang Bruce and Eva Marie Lauer Lauren Sproull Pennsylvania Department of Health David and Debra Hines Lester Sdorow Henry Chuang James and Hope Leahey Denise Stern Henry Ho Richard Senker Christopher and June Leavy Jeanne Stern We apologize for any errors or omissions in the Robert Cohen donor list despite our best efforts to be as accurate Dorothy Hopkins John and Susan Shelly Anthony Colella King Liang Christian Stranutu as possible. Please contact [email protected] or David Huang James and Erica Shrimp Joan Copp Michael and Donna Line Terry Strickland, II call 215-489-4900 so that we can print corrections Paul and Laura Hunter Nancy Marie Sidun Lorie Corley Erica Litschi Janet Tangney in our next newsletter. Thank you. RESEARCH, Education and Advocacy IS THE KEY Hepatitis B is an enormous global health problem. • 2 billion people worldwide have been infected by hepatitis B. (1 out of every 3) • 1 million people in the world die from hepatitis B each year. Hepatitis B causes 80% of primary liver cancer worldwide. • Liver cancer is the 3rd leading cause of death in the world. • In the U.S., liver cancer rates are increasing as most other types of cancer are decreasing. • The hepatitis B vaccine is the 1st anti-cancer vaccine — by preventing a hepatitis B infection. There is no known cure for more than 400 million people worldwide living with hepatitis B. • Hepatitis B is preventable and treatable — now let’s make it curable!

Learn more about hepatitis B and the important work of the Hepatitis B Foundation by visiting www.hepb.org.