2010 ANNUAL REPORT RESEARCH OUTREACH ADVOCACY 3 Hepat itis B Foundation “We appreciate [the HBF’s] continued support of the Hep B community. With the addition of a second adopted child DearThe Hepatitis Friends, B Foundation has enjoyed one of its most with hep B into our family, we obviously 2010 Annual Report productive years despite the economic downturn. We are are supportive of your efforts in pleased to report that our work has been a bright spot in RESEARCH research and education.” one of the toughest years. YEAR IN REVIEW (New Jersey) This year we have focused our efforts on making the FINANCIAL INFORMatioN* greatest impact on some of the greatest unmet needs. (Fiscal Year 2010 ending June 30, 2010) IN THE LABS This includes establishing consensus recommendations Sources of Funds – HBF & IHVR Combined for hepatitis B screening and treatment of children who (Total $4,322,068) live with this disease and for primary care providers who Charitable lack clear guidelines. Grants 84% Contributions 11% $3,649,257 $475,492 Research results take longer, but we have impressive Interest >1% LIVING SCIENCE and tangible results to share, too. This year, the liver $3,157 Building for a Cure cancer biomarker that we helped to discover has been Other 4% $194,162 HBF’s groundbreaking for the expansion optioned to a major diagnostics company. If all goes well, of its research facility to build nine new this blood test will be available for human use within the labs, which includes a teaching lab, • Biomarkers of liver cancer enter next couple of years. represented a bright spot during a tough advanced option development with So, if this is what we can accomplish in a tough year, economy. Funding for the $1.4 million Abbott Diagnostics (Block et al) • New pathway of HBV DNA synthesis it has only got to become easier! Thanks to all of you for renovation project was provided in part • Biomarkers of liver fibrosis are good discovered (Guo et al, Journal of Virology 2009) your continued support, donations and confidence by the HBF and its research organization, enough to advance to testing in 15,000 in our mission. the Institute for Hepatitis and Virus people with Johns Hopkins University • New drug (alkylated porphoryn) Research, and Univest. in an NIH-funded study discovered that inactivates HBV, HCV, & (Mehta et al, in progress) HIV without harming mammalian cells Sincerely, Uses of Funds – HBF & IHVR Combined (Guo et al, submitted 2010) (Total $4,028,054) • Primabody, marker of infectious disease, validated in animal studies • Glucovir drug enhances immune attack Timothy M. Block, Ph.D. Outreach and (Chen/Romano et al, in preparation) against hepatitis B in woodchucks President and Co-Founder Research 56% Education 21% $2,222,270 $834,920 (Norton et al, Hepatology 2010) • Liver carcinoid drug successfully completes Phase II human studies • Liver cancer drug to be tested in animals (Shailubhai et al, in progress with Callisto, Inc.) (Cuconati et al, in progress) Public Health 4% Joel D. Rosen, Esq. $188,538 • Urine DNA test for colorectal cancer and • New glucovir compound protects animals Chairman of the Board polyps and liver cancer gets major award from Dengue disease Supporting Services 5% PA state senator Chuck McIlhinney (3rd from from the Coulter Foundation (Su et al) (Chang et al, submitted 2010) $210,400 right) and PA Congressman Patrick Murphy (2nd to right) and PA state representatives • Human gene products discovered that • Serum micro arrays can represent 8,000 Marguerite Quinn (center) and Kathy Watson repress hepatitis B, C and other viruses different people on a single small “chip” General and (Guo et al, Journal of Virology 2009) (Chen et al, in progress) Administrative 14% (right) joined HBF to lend their support at $571,926 our groundbreaking ceremony at the PA Biotechnology Center (Jan 2010). HBF manages HBF’s research is conducted in partnership with Drexel University College of Medicine, and co-owns the Center, which it created in whose labs are located at our Biotech Center. * This audited financial information includes revenue and expenses from HBF and its 2006 to accelerate its research mission. research institute IHVR, but excludes the Foundation’s 50% ownership (or $6.9 million) in the PA Biotechnology Center valued at $13.8 million as per audited statements. 4 5 Hepat Board of Directors Biotechnology Faculty State Recognition for HBF Research International HBV Meeting 2009 Bruce Witte Lecturer 2010 Chairman William Kinney, PhD itis B Foundation Joel Rosen, Esq. Mohan Philip, PhD, MBA In a special HBF coordinates this prestigious international scientific President Adjunct Research Faculty ceremony at the meeting each year that attracts hundreds of researchers from Timothy Block, PhD These Drexel U. research faculty members state Capital, around the world to work at our research center and are Vice President supported in part by HBF/IVHR funds 2010 Annual Report PA Governor discuss the science W. Thomas London, MD Jinhong Chang, MD, PhD Ed Rendell of hepatitis B and Treasurer Mary Ann Communale, MS announced new D viruses. This R. Donald Leedy, MBA Yanming Du, PhD Alison Evans, ScD grant awards year the meeting Secretary Haitao Guo, PhD to support was held in the Janine Witte Ju-Tao Guo, MD the important work of research groups that included the beautiful Loire Dr. T. Jake Liang (left), from the National Joan M. Block, RN, BSN Xuanyong Lu, PhD Anand Mehta, D.Phil HBF and its research institute – the Institute for Hepatitis Valley in France. Institutes of Health, gave the 9th Annual Thomas Block Stanley Broadbent Tulin Morcol, PhD and Virus Research (IHVR) – which is led by HBF/IHVR Bruce Witte Lecture about “Choreographing 2009 Meeting co-chairs Dr. Camille Sureau (France) and Alan Brownstein, MPH Brad Nefsky, PhD president Dr. Timothy Block (far left). (June 2010) Dr. Stephen Locarnini (Australia) model the unique HBV ties the Tango between Hepatitis C Virus and Cells Sandra Budinsky Pamela Norton, PhD given by HBF at the concluding banquet dinner. (Oct. 2009) by Functional Genomic Screen.” The lecture James Datin Allen Reitz, PhD Ying-Hsiu Su, PhD series was established by HBF co-founders Kimberly Jungkind, RN, MPH Dale Kindregan Executive Director Paul and Janine Witte. (April 2010) Charles Sigety, Esq. Joan M. Block, RN, BSN Gurney Sloan, Esq. Catharine Williams, MGA Chief Business Officer HBF Distinguished Scientist Robert Zivin, PhD Nelson Carvalho, MBA Director of Programs Award 2010 Medical and Scientific Advisors Margaret Farley, MBA TRAINING YOUNG SCIENTISTS Harvey Alter, MD Timothy Block, PhD Director of Accounting Summer College Research The High School Enrichment Baruch Blumberg, MD, PhD Patti McAloon, MBA Internships provide a wonderful (and Program offers a two-week “hands-on” Carol Brosgart, MD Director of Operations/IT Nathaniel Brown, MD paid) opportunity for students to work experience in a professional lab for Konrad Kroszner Raymond Dwek, D Phil, FRS on an independent research project with students entering their senior year. Lawrence Friedman, MD Outreach and Public Health senior scientists for a 10-week period. Interactive seminars led by leaders in the Robert Gish, MD Nina Baltierra Funding is provided by grants from field introduce them to careers in science, Hie-Won L. Hann, MD Gang Chen, MD, PhD W. Thomas London, MD Chari Cohen, MPH (DrPh candidate) the PA Department of Health, Merck’s medicine, patent law, public health and “ Working as a young scientist William Mason, PhD Jackie Corwell West Point Charitable Contributions more. This program is supported in part Dr. R. Palmer Beasley (center), Brian McMahon, MD Richard Kahn, MPH is a unique experience. Many Kenneth Rothstein, MD Kelly La (MPH candidate) Committee, and the Charles Sigety by Pennsylvania EITC funds received from accompanied by his wife and research doors of opportunity have Family Foundation. Universal Health Services of Delaware Raymond Schinazi, PhD Loretta Molle collaborator Dr. Lu Yu Wang, received the Bud Tennant, DVM Lauren Nonini opened for me and to others and Wal-Mart Stores, Inc. Distinguished Scientist Award from HBF like me in the [HBF labs]. We are president Dr. Timothy Block (left) and Senior Research Faculty The Apprenticeship Program is Songming Chen, PhD encouraged to be unafraid in Nobel Laureate Dr. Baruch Blumberg designed for the recent college graduate who Andrea Cuconati, PhD our insights, and to realize that (right) at the Crystal Ball for his seminal HBV Surendra Dheer, PhD wants to gain real-life research experience every new discovery comes research conducted in Taiwan that identified Sergey Ilyin, PhD before making a decision to pursue graduate Ramila Philip, PhD mother-to-newborn transmission and the from both standing on the or medical education. They receive valuable David Ren, MD, PhD fatal link to primary liver cancer. He served shoulders of giants and from mentorship and encouragement to become Patrick Romano, PhD as Chair of the National Academies Institute Thomas Russell, PhD pioneering new ideas.” deeply involved in their research projects Kunwar Shailubhai, PhD, MBA of Medicine (IOM) committee that published Anne Lamontagne, former Research and to participate in the intellectual world James Thacker, PhD in January 2010 the first IOM report on Apprentice now in graduate school. of scientists through research rounds, Michael Xu, PhD “Hepatitis and Liver Cancer”. (April 2010) journal clubs, and special seminars. 6 7 Hepat “Your website has been an Drug Discovery itis B Foundation