General Surgery Curriculum – Operative Management
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Hepatic Surgery
Hepatic Surgery Honorary Editors: Tan To Cheung, Long R. Jiao Editors: Zhiming Wang, Giovanni Battista Levi Sandri, Alexander Parikh Associate Editors: Yiming Tao, Michael D. Kluger, Romaric Loffroy Editors: Zhiming Wang, Giovanni Battista Levi Sandri, Levi Battista Giovanni Alexander Parikh Hepatic Surgery Honorary Editors: Tan To Cheung, Long R. Jiao Editors: Zhiming Wang, Giovanni Battista Levi Sandri, Alexander Parikh Associate Editors: Yiming Tao, Michael D. Kluger, Romaric Loffroy AME Publishing Company Room C 16F, Kings Wing Plaza 1, NO. 3 on Kwan Street, Shatin, NT, Hong Kong Information on this title: www.amegroups.com For more information, contact [email protected] Copyright © AME Publishing Company. All rights reserved. This publication is in copyright. Subject to statutory exception and to the provisions of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of AME Publishing Company. First published in 2018 Printed in China by AME Publishing Company Editors: Zhiming Wang, Giovanni Battista Levi Sandri, Alexander Parikh Hepatic Surgery (Hard Cover) ISBN: 978-988-78919-1-8 AME Publishing Company, Hong Kong AME Publishing Company has no responsibility for the persistence or accuracy of URLs for external or third-party internet websites referred to in this publication, and does not guarantee that any content on such websites is, or will remain, accurate or appropriate. The advice and opinions expressed in this book are solely those of the authors and do not necessarily represent the views or practices of the publisher. No representation is made by the publisher about the suitability of the information contained in this book, and there is no consent, endorsement or recommendation provided by the publisher, express or implied, with regard to its contents. -
Cefoxitin Versus Piperacillin– Tazobactam As Surgical Antibiotic Prophylaxis in Patients Undergoing Pancreatoduodenectomy: Protocol for a Randomised Controlled Trial
Open access Protocol BMJ Open: first published as 10.1136/bmjopen-2020-048398 on 4 March 2021. Downloaded from Cefoxitin versus piperacillin– tazobactam as surgical antibiotic prophylaxis in patients undergoing pancreatoduodenectomy: protocol for a randomised controlled trial Nicole M Nevarez ,1 Brian C Brajcich,2 Jason Liu,2,3 Ryan Ellis,2 Clifford Y Ko,2 Henry A Pitt,4 Michael I D'Angelica,5 Adam C Yopp1 To cite: Nevarez NM, ABSTRACT Strengths and limitations of this study Brajcich BC, Liu J, et al. Introduction Although antibiotic prophylaxis is Cefoxitin versus piperacillin– established in reducing postoperative surgical site tazobactam as surgical ► A major strength of this study is the multi- infections (SSIs), the optimal antibiotic for prophylaxis in antibiotic prophylaxis institutional, double- arm, randomised controlled in patients undergoing pancreatoduodenectomy (PD) remains unclear. The study trial design. objective is to evaluate if administration of piperacillin– pancreatoduodenectomy: ► A limitation of this study is that all perioperative care protocol for a randomised tazobactam as antibiotic prophylaxis results in decreased is at the discretion of the operating surgeon and is controlled trial. BMJ Open 30- day SSI rate compared with cefoxitin in patients not standardised. 2021;11:e048398. doi:10.1136/ undergoing elective PD. ► All data will be collected through the American bmjopen-2020-048398 Methods and analysis This study will be a multi- College of Surgeons National Surgical Quality ► Prepublication history for institution, double- arm, non- blinded randomised controlled Improvement Program, which is a strength for its this paper is available online. superiority trial. Adults ≥18 years consented to undergo PD ease of use but a limitation due to the variety of data To view these files, please visit for all indications who present to institutions participating included. -
Extraneal PI Brunei.Pdf
BAXTER EXTRANEAL Peritoneal Dialysis Solution The drained fluid should be inspected for the presence of fibrin or cloudiness, with 7.5% Icodextrin which may indicate the presence of peritonitis. For intraperitoneal administration only Safety and effectiveness in pediatric patients have not been established. Protein, amino acids, water-soluble vitamins, and other medicines may be lost PATIENT LEAFLET during peritoneal dialysis and may require replacement. Peritoneal dialysis should be done with caution in patients with: Product name 1) abdominal conditions, including disruption of the peritoneal membrane and EXTRANEAL (Icodextrin 7.5%) diaphragm by surgery, from congenital anomalies or trauma until healing is complete, abdominal tumors, abdominal wall infection, hernias, fecal Composition fistula, colostomy, or ileostomy, frequent episodes of diverticulitis, EXTRANEAL is a sterile solution for intraperitoneal administration. inflammatory or ischemic bowel disease, large polycystic kidneys, or other conditions that compromise the integrity of the abdominal wall, abdominal Each 100 ml of EXTRANEAL contains: Electrolyte solution content per 1000 ml: surface, or intra-abdominal cavity; and Icodextrin 7.5 g Sodium 132 mmol 2) other conditions including aortic graft placement and severe pulmonary Sodium Chloride 538 mg Calcium 1.75 mmol disease. Patients should be carefully monitored to avoid over- and underhydration, Sodium Lactate 448 mg Magnesium 0.25 mmol which may have severe consequences including congestive heart failure, Calcium Chloride 25.7 mg Chloride 96 mmol volume depletion and shock. An accurate fluid balance record should be kept and the patient’s body weight monitored. Magnesium Chloride 5.08mg Lactate 40 mmol Overinfusion of an EXTRANEAL volume into the peritoneal cavity may be Theoretical osmolarity 284 (milliosmoles per litre). -
Intermittent Pringle Maneuver May Be Beneficial for Radiofrequency Ablations in Situations with Tumor-Vessel Proximity
Innov Surg Sci 2018; 3(4): 245–251 Original Article Franz G.M. Poch*, Christina A. Neizert, Ole Gemeinhardt, Beatrice Geyer, Katharina Eminger, Christian Rieder, Stefan M. Niehues, Janis Vahldiek, Stefan F. Thieme and Kai S. Lehmann Intermittent Pringle maneuver may be beneficial for radiofrequency ablations in situations with tumor-vessel proximity https://doi.org/10.1515/iss-2018-0008 of ablation area could be measured on the margin of Received February 11, 2018; accepted April 11, 2018; previously the ablations with an intermittent PM, starting without published online May 11, 2018 hepatic inflow occlusion (p < 0.05). Abstract Conclusion: An intermittent PM did not lead to smaller ablations compared to a continuous or no PM ex vivo. Background: Radiofrequency ablation (RFA) represents Furthermore, an intermittent PM can increase the abla- a treatment option for non-resectable liver malignancies. tion area when initial hepatic inflow is succeeded by a PM. Larger ablations can be achieved with a temporary hepatic Keywords: cooling effect; hepatic; liver; multipolar; radi- inflow occlusion (Pringle maneuver – PM). However, a PM ofrequency ablation. can induce dehydration and carbonization of the target tissue. The objective of this study was to evaluate the impact of an intermittent PM on the ablation size. Methods: Twenty-five multipolar RFAs were performed in Introduction porcine livers ex vivo. A perfused glass tube was used to Radiofrequency ablation (RFA) is an important therapy simulate a natural vessel. The following five test series (each option for the treatment of non-resectable malignant liver n = 5) were conducted: (1) continuous PM, (2–4) intermittent tumors [1, 2]. -
Traumatic Haemoabdomen
Zurich Open Repository and Archive University of Zurich Main Library Strickhofstrasse 39 CH-8057 Zurich www.zora.uzh.ch Year: 2010 Traumatic haemoabdomen Sigrist, Nadja ; Spreng, D Abstract: Haemoabdomen is an important differential diagnosis for canine and feline abdominal trauma. The diagnosis is made by aspiration of blood from the abdomen by abdominocentesis. Spleen and liver are the most likely sources of traumatic bleeding. Patients are stabilized with appropriate fl uid therapy, oxygen supplementation and analgesia. With ongoing haemorrhage, serial measurement of abdominal and venous haematocrit can be helpful in making the decision between surgical and medical therapy. Most patients with traumatic haemoabdomen can be treated medically. Surgical therapy should be reserved for patients that cannot be stabilized despite medical intervention. The surgical approach should be thoroughly planned in order to minimize further abdominal blood loss and blood transfusions should be readily available. Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-123588 Journal Article Published Version Originally published at: Sigrist, Nadja; Spreng, D (2010). Traumatic haemoabdomen. European Journal of Companion Animal Practice (EJCAP), 20(1):45-52. CRITICAL CARE REPRINT PAPER (CH) Traumatic Haemoabdomen N. Sigrist(1), D. Spreng(1) SUMMARY Traumatic haemoabdomen Haemoabdomen is an important differential diagnosis for canine and feline abdominal trauma. The diagnosis is made by aspiration of blood from the abdomen by abdominocentesis. Spleen and liver are the most likely sources of traumatic bleeding. Patients are stabilized with appropriate fl uid therapy, oxygen supplementation and analgesia. With ongoing haemorrhage, serial measurement of abdominal and venous haematocrit can be helpful in making the decision between surgical and medical therapy. -
Bicycle Handlebar Injury in a Child Resulting
ical C lin as Grosek et al., J Clin Case Rep 2020, 10:2 C e f R o l e a p n o r r t u s o J Journal of Clinical Case Reports ISSN: 2165-7920 Case Report Open Access Bicycle Handlebar Injury in a Child Resulting in Complex Liver Laceration with Massive Bleeding and Bile Leakage: A Case Report Grosek J1,2, Cebron Z1,2, Janez J1,2 and Tomazic A1,2* 1Department of Abdominal Surgery, University Medical Centre Ljubljana, Zaloska 7, Ljubljana, Slovenia 2Medical Faculty, University of Ljubljana, Vrazov Trg 2, Ljubljana, Slovenia Abstract Background: Bicycle accidents are a significant cause of traumatic morbidity in the paediatric population. The handlebar injuries are usually isolated and remain a major source of bicycle related morbidity. We present a case of severe liver laceration with left hepatic duct transection caused by handlebar trauma in a 13-year-old boy. Case presentation: An otherwise healthy 13-year-old Caucasian male patient was rushed to the hospital following a blunt abdominal trauma from a bicycle handlebar. An ultrasound finding of extensive free intraperitoneal fluid with accompanying features of hemodynamic instability necessitated a decision to perform an emergency exploratory laparotomy. Operative findings included massive haemoperitoneum, a deep laceration almost separating left and right liver lobes, and a near-complete interruption of the left hepatic duct. Interestingly, the vascular anatomy of the left liver lobe was preserved. Surgical haemostasis was successfully accomplished, and a duct-to-duct anastomosis of the ruptured left hepatic duct was performed. A T-tube biliary drainage was inserted, and intraoperative cholangiography showed no extraluminal spillage of contrast. -
Classification of Livertrauma
HPB Surgery, 1996, Vol.9, pp.235-238 (C) 1996 OPA (Overseas Publishers Association) Reprints available directly from the publisher Amsterdam B.V. Published in The Netherlands Photocopying permitted by license only by Harwood Academic Publishers GmbH Printed in Malaysia Classification of Liver Trauma SANDRO B. RIZOLI, FREDERICK D. BRENNEMAN, SHERIF S. HANNA, and KAMYAR KAHNAMOUI Department of Surgery and the Trauma Program, Sunnybrook Health Science Centre, University of Toronto, Toronto, Ontario, Canada (Received 30 June 1994) The classification of liver injuries is important for clinical practice, clinical research and quality assurance activities. The Organ Injury Scaling (OIS) Committee of the American Association for the Surgery of Trauma proposed the OIS for liver trauma in 1989. The purpose of the present study was to apply this scale to a cohort of liver trauma patients managed at a single Canadian trauma centre from January 1987 to June 1992.170 study patients were identified and reviewed. The mean age was 30, with 69% male and a mean ISS of 33.90% had a blunt mechanism of injury. The 170 patients were categorized into the 60IS grades of liver injury. The number of units of blood transfused, the magnitude of the operative treatment required, the liver-related complications and the liver-related mortality correlated well with the OIS grade. The OIS grade was unable to predict the need for laparotomy or the length of stay in hospital. We conclude that the OIS is a useful, practical and important tool for the categorization of liver injuries, and it may prove to be the universally accepted classification scheme in liver trauma. -
Peritoneal Dialysis in the 21St Century: an Analysis of Current Problems and Future Developments
J Am Soc Nephrol 13: S104–S116, 2002 Peritoneal Dialysis in the 21st Century: An Analysis of Current Problems and Future Developments RAM GOKAL Manchester Royal Infirmary, Manchester, United Kingdom. One major development in the field of kidney diseases in the of death on PD as compared with HD and by and large found 21st century will be in prevention of end-stage renal disease that mortality risk was equal for HD and PD in the various (ESRD). Basic research has made inroads into the understand- studies reported. After this analysis was the report of Bloem- ing of the mechanisms of progression of chronic renal failure, bergen et al. (2), which was based on the US Renal Data including the understanding of the functions of genes activated Systems (USRDS) data on prevalent patients (1987, 1988, and by renal damage. All this may well result in a major reduction 1989). This showed that PD subjects had a 19% higher risk of in the incidence of ESRD. The second important development mortality as compared with patients who used HD. This was will be in transplantation, which will constitute the mainstay of met with considerable consternation in the United States and ESRD treatment in the next century. The clinical introduction probably did the therapy a major disservice. Analysis from the of xenotransplantation and the cloning of one’s own organs via Canadian Organ Replacement Registry on patients starting one’s stem cells may well represent the major areas of replace- RRT between 1990 and 1994 showed that for incident patients, ment therapy. This will reduce dialysis as a method to support the survival with PD was better in the first 2 yr of treatment the main treatments. -
Antibiotic Prophylaxis in Peritoneal Dialysis Patients
Advances in Peritoneal Dialysis, Vol. 33, 2017 Antibiotic Prophylaxis in Miten J. Dhruve, Joanne M. Bargman Peritoneal Dialysis Patients Peritonitis is an important cause of morbidity, Discussion mortality, and technique failure in patients on peri- toneal dialysis (PD). The most effective approach Endoscopy in PD patients to peritonitis is prevention, which includes careful Several studies have looked at PD patients undergoing patient training and follow-up. Although peritonitis colonoscopy. Yip et al. (4) reported on 97 colonosco- as a result of contiguous spread of bacteria or fungi pies performed in 77 patients, observing a 6.3% rate of during invasive procedures, or as a result of seeding peritonitis after colonoscopy. Patients who were given of the peritoneum during bacteremia, is uncommon, prophylactic antibiotics did not develop colonoscopy- the likelihood of such spread is often predictable, and related peritonitis. The authors also noted that no in- the risk can be mitigated with antibiotic prophylaxis. crease in the rate of peritonitis was observed in patients Here, we describe the rationale for, and approach to, who underwent polypectomy. Wu et al. (5) reported a antibiotic prophylaxis in PD patients for the preven- similar post-endoscopy peritonitis rate of 6.4% and tion of infective episodes. noted that no patient prescribed prophylactic antibiot- ics developed peritonitis. In addition, several other Key words small case reports demonstrated the phenomenon of Antibiotics, peritonitis, prevention, bacteremia peritonitis after colonoscopy, with some even reporting a much higher rate of peritonitis (increased by a factor Introduction of 3 – 5) in patients undergoing polypectomy than in Peritonitis is the leading cause of technique failure those having nontherapeutic colonoscopy (5–9). -
Antibiotic Prophylaxis for GI Endoscopy
GUIDELINE Antibiotic prophylaxis for GI endoscopy This is one of a series of statements discussing the use of procedure. Endoscopy-related bacteremia carries a small GI endoscopy in common clinical situations. The Stan- risk of localization of infection in remote tissues (ie, infec- dards of Practice Committee of the American Society for tive endocarditis [IE]). Endoscopy also may result in local Gastrointestinal Endoscopy (ASGE) prepared this docu- infections in which a typically sterile space or tissue is ment, and it updates a previously issued document on breached and contaminated by an endoscopic accessory this topic.1 In preparing this guideline, MEDLINE and or by contrast material injection. This document is an up- PubMed databases were used to search for publications date of the prior ASGE document on antibiotic prophylaxis between January 1975 and December 2013 pertaining for GI endoscopy,1 discusses infectious adverse events to this topic. The search was supplemented by accessing related to endoscopy, and provides recommendations for the “related articles” feature of PubMed, with articles periprocedural antibiotic therapy. identified on MEDLINE and PubMed as the references. Additional references were obtained from the bibliogra- phies of the identified articles and from recommenda- BACTEREMIA ASSOCIATED WITH tions of expert consultants. When few or no data were ENDOSCOPIC PROCEDURES available from well-designed prospective trials, emphasis was given to results from large series and reports from Bacteremia can occur after endoscopic procedures and has been advocated as a surrogate marker for IE risk. How- recognized experts. Weaker recommendations are indi- fi cated by phrases such as “We suggest.” whereas stronger ever, clinically signi cant infections are extremely rare. -
Liau-Report.Pdf
SOCIETY FOR SURGERY OF THE ALIMENTARY TRACT KAREN AND JOSEF E. FISCHER INTERNATIONAL TRAVELING FELLOWSHIP FOR SURGEONS IN ACADEMIC PRACTICE 2018 REPORT Fellow: Siong-Seng Liau, MD, FRCS ‐ Addenbrooke’s Hospital, Cambridge, United Kingdom Travel Dates: Oct 31-November 13, 2018 Hosts: 1) Professor Sung-Gyu Lee, Division of Liver Transplantation and Hepatobiliary Surgery, Asan Medical Centre, Seoul, South Korea 2) Professor Jin-Young Jang, Division of Hepatopancreatobiliary Surgery, Seoul National University Hospital, Seoul, South Korea 3) Professor Ho-Seong Han, Division of Hepatopancreatobiliary Surgery, Seoul National University Bundang Hospital, Seoul, South Korea Meeting: Annual Congress of Korean Surgical Society 2018 & 70th Congress of the Korean Surgical Society, Nov 1-3, Seoul, South Korea Report: I wish to thank Mrs Karen Fischer, Dr Josef Fischer, and the Society for Surgeons of the Alimentary Tract for this immense privilege to be the 2018 SSAT-Fischer International Travelling Fellow. I visited 3 major Hepatopancreatobiliary (HPB) centres in Seoul over the course of two weeks. This experience exceeded all my expectations. I planned this visit to focus on minimally- invasive HPB surgery. During this time, I witnessed a wide spectrum of HPB surgeries, including laparoscopic and robotic-assisted approaches. Seoul is indeed the ‘mecca’ of HPB surgery with the major HPB units in close vicinity to each other, making it convenient to visit each of these centres during the same fellowship. Further, I was able to coincide my fellowship with the Annual Congress of Korean Surgical Society, held annually in Seoul. My fellowship started at the Division of HPB Surgery and Liver Transplantation in Asan Medical Centre (AMC). -
Anatomy of the Gallbladder and Bile Ducts
BASIC SCIENCE the portal vein lies posterior to these structures; Anatomy of the gallbladder the inferior vena cava, separated by the epiploic foramen (the foramen of Winslow) lies still more posteriorly, and bile ducts behind the portal vein. Note that haemorrhage during gallbladder surgery may be Harold Ellis controlled by compression of the hepatic artery, which gives off the cystic branch, by passing a finger through the epiploic foramen (foramen of Winslow), and compressing the artery Abstract between the finger and the thumb placed on the anterior aspect A detailed knowledge of the gallbladder and bile ducts (together with of the foramen (Pringle’s manoeuvre). their anatomical variations) and related blood supply are essential in At fibreoptic endoscopy, the opening of the duct of Wirsung the safe performance of both open and laparoscopic cholecystectomy can usually be identified quite easily. It is seen as a distinct as well as the interpretation of radiological and ultrasound images of papilla rather low down in the second part of the duodenum, these structures. These topics are described and illustrated. lying under a characteristic crescentic mucosal fold (Figure 2). Unless the duct is obstructed or occluded, bile can be seen to Keywords Anatomical variations; bile ducts; blood supply; gallbladder discharge from it intermittently. The gallbladder (Figures 1 and 3) The biliary ducts (Figure 1) The normal gallbladder has a capacity of about 50 ml of bile. It concentrates the hepatic bile by a factor of about 10 and also The right and left hepatic ducts emerge from their respective sides secretes mucus into it from the copious goblet cells scattered of the liver and fuse at the porta hepatis (‘the doorway to the throughout its mucosa.