Invasive Procedures Preparing a PD Patient
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Cefoxitin Versus Piperacillin– Tazobactam As Surgical Antibiotic Prophylaxis in Patients Undergoing Pancreatoduodenectomy: Protocol for a Randomised Controlled Trial
Open access Protocol BMJ Open: first published as 10.1136/bmjopen-2020-048398 on 4 March 2021. Downloaded from Cefoxitin versus piperacillin– tazobactam as surgical antibiotic prophylaxis in patients undergoing pancreatoduodenectomy: protocol for a randomised controlled trial Nicole M Nevarez ,1 Brian C Brajcich,2 Jason Liu,2,3 Ryan Ellis,2 Clifford Y Ko,2 Henry A Pitt,4 Michael I D'Angelica,5 Adam C Yopp1 To cite: Nevarez NM, ABSTRACT Strengths and limitations of this study Brajcich BC, Liu J, et al. Introduction Although antibiotic prophylaxis is Cefoxitin versus piperacillin– established in reducing postoperative surgical site tazobactam as surgical ► A major strength of this study is the multi- infections (SSIs), the optimal antibiotic for prophylaxis in antibiotic prophylaxis institutional, double- arm, randomised controlled in patients undergoing pancreatoduodenectomy (PD) remains unclear. The study trial design. objective is to evaluate if administration of piperacillin– pancreatoduodenectomy: ► A limitation of this study is that all perioperative care protocol for a randomised tazobactam as antibiotic prophylaxis results in decreased is at the discretion of the operating surgeon and is controlled trial. BMJ Open 30- day SSI rate compared with cefoxitin in patients not standardised. 2021;11:e048398. doi:10.1136/ undergoing elective PD. ► All data will be collected through the American bmjopen-2020-048398 Methods and analysis This study will be a multi- College of Surgeons National Surgical Quality ► Prepublication history for institution, double- arm, non- blinded randomised controlled Improvement Program, which is a strength for its this paper is available online. superiority trial. Adults ≥18 years consented to undergo PD ease of use but a limitation due to the variety of data To view these files, please visit for all indications who present to institutions participating included. -
Extraneal PI Brunei.Pdf
BAXTER EXTRANEAL Peritoneal Dialysis Solution The drained fluid should be inspected for the presence of fibrin or cloudiness, with 7.5% Icodextrin which may indicate the presence of peritonitis. For intraperitoneal administration only Safety and effectiveness in pediatric patients have not been established. Protein, amino acids, water-soluble vitamins, and other medicines may be lost PATIENT LEAFLET during peritoneal dialysis and may require replacement. Peritoneal dialysis should be done with caution in patients with: Product name 1) abdominal conditions, including disruption of the peritoneal membrane and EXTRANEAL (Icodextrin 7.5%) diaphragm by surgery, from congenital anomalies or trauma until healing is complete, abdominal tumors, abdominal wall infection, hernias, fecal Composition fistula, colostomy, or ileostomy, frequent episodes of diverticulitis, EXTRANEAL is a sterile solution for intraperitoneal administration. inflammatory or ischemic bowel disease, large polycystic kidneys, or other conditions that compromise the integrity of the abdominal wall, abdominal Each 100 ml of EXTRANEAL contains: Electrolyte solution content per 1000 ml: surface, or intra-abdominal cavity; and Icodextrin 7.5 g Sodium 132 mmol 2) other conditions including aortic graft placement and severe pulmonary Sodium Chloride 538 mg Calcium 1.75 mmol disease. Patients should be carefully monitored to avoid over- and underhydration, Sodium Lactate 448 mg Magnesium 0.25 mmol which may have severe consequences including congestive heart failure, Calcium Chloride 25.7 mg Chloride 96 mmol volume depletion and shock. An accurate fluid balance record should be kept and the patient’s body weight monitored. Magnesium Chloride 5.08mg Lactate 40 mmol Overinfusion of an EXTRANEAL volume into the peritoneal cavity may be Theoretical osmolarity 284 (milliosmoles per litre). -
Pictures of Central Venous Catheters
Pictures of Central Venous Catheters Below are examples of central venous catheters. This is not an all inclusive list of either type of catheter or type of access device. Tunneled Central Venous Catheters. Tunneled catheters are passed under the skin to a separate exit point. This helps stabilize them making them useful for long term therapy. They can have one or more lumens. Power Hickman® Multi-lumen Hickman® or Groshong® Tunneled Central Broviac® Long-Term Tunneled Central Venous Catheter Dialysis Catheters Venous Catheter © 2013 C. R. Bard, Inc. Used with permission. Bard, are trademarks and/or registered trademarks of C. R. Bard, Inc. Implanted Ports. Inplanted ports are also tunneled under the skin. The port itself is placed under the skin and accessed as needed. When not accessed, they only need an occasional flush but otherwise do not require care. They can be multilumen as well. They are also useful for long term therapy. ` Single lumen PowerPort® Vue Implantable Port Titanium Dome Port Dual lumen SlimPort® Dual-lumen RosenblattTM Implantable Port © 2013 C. R. Bard, Inc. Used with permission. Bard, are trademarks and/or registered trademarks of C. R. Bard, Inc. Non-tunneled Central Venous Catheters. Non-tunneled catheters are used for short term therapy and in emergent situations. MAHURKARTM Elite Dialysis Catheter Image provided courtesy of Covidien. MAHURKAR is a trademark of Sakharam D. Mahurkar, MD. © Covidien. All rights reserved. Peripherally Inserted Central Catheters. A “PICC” is inserted in a large peripheral vein, such as the cephalic or basilic vein, and then advanced until the tip rests in the distal superior vena cava or cavoatrial junction. -
Traumatic Haemoabdomen
Zurich Open Repository and Archive University of Zurich Main Library Strickhofstrasse 39 CH-8057 Zurich www.zora.uzh.ch Year: 2010 Traumatic haemoabdomen Sigrist, Nadja ; Spreng, D Abstract: Haemoabdomen is an important differential diagnosis for canine and feline abdominal trauma. The diagnosis is made by aspiration of blood from the abdomen by abdominocentesis. Spleen and liver are the most likely sources of traumatic bleeding. Patients are stabilized with appropriate fl uid therapy, oxygen supplementation and analgesia. With ongoing haemorrhage, serial measurement of abdominal and venous haematocrit can be helpful in making the decision between surgical and medical therapy. Most patients with traumatic haemoabdomen can be treated medically. Surgical therapy should be reserved for patients that cannot be stabilized despite medical intervention. The surgical approach should be thoroughly planned in order to minimize further abdominal blood loss and blood transfusions should be readily available. Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-123588 Journal Article Published Version Originally published at: Sigrist, Nadja; Spreng, D (2010). Traumatic haemoabdomen. European Journal of Companion Animal Practice (EJCAP), 20(1):45-52. CRITICAL CARE REPRINT PAPER (CH) Traumatic Haemoabdomen N. Sigrist(1), D. Spreng(1) SUMMARY Traumatic haemoabdomen Haemoabdomen is an important differential diagnosis for canine and feline abdominal trauma. The diagnosis is made by aspiration of blood from the abdomen by abdominocentesis. Spleen and liver are the most likely sources of traumatic bleeding. Patients are stabilized with appropriate fl uid therapy, oxygen supplementation and analgesia. With ongoing haemorrhage, serial measurement of abdominal and venous haematocrit can be helpful in making the decision between surgical and medical therapy. -
Renovascular Hypertension
z RENOGRAM INIS-mf —11322 RENOVASCULAR HYPERTENSION G.G. Geyskes STELLINGEN Behorende bij het proefschrift THE RENOGRAM IN RENOVASCULAR HYPERTENSION door G.G. Geyskes \ "n. it f 1 VII Het captopril renogratn kan de diagnostische PTA zoals door Maxwell Paranormale geneeskunde bij patiënten met hypertensie heeft meer bepleit vrijwel vervangen. subjectieve dan objectieve effecten. M.H. Maxwell. A.V. Walu. Hyptritnsion 1914.6:589-392. II VIII Bij dubbelzijdige nierarteriestenose geeft ncfrectomie van een kleine Het lijkt mogelijk de ontwikkeling van diabetische nefropathie af te nier in combinatie met PTA van de contralaterale nier vaak verbetering remmen door medicamenteuze antihypertensieve therapie, speciaal met van de totale nierfunktie. converting enzyme inhibitors. Ill IX Onderdrukking van de PRA is een antihyperteniief mechanisme van Het roken van sigaretten kan een oorzaak van renovaculaire hyperten- betaMokkers. sie zijn. G.G. Geyskts. J. Vos. P. Boer. E.J. Dorhoul Mets. Lmcei 1976:1049-1051. CE. Grimm el al. Nrphron 1986. 44 SI: 96-100. IV Contractie van het extracellulair volume is een antihyperteniief mecha- Het metaiodobenzylguanidine scintigram is een aanwinst bij de diag- nisme van diuretka. nostiek van het feochromocytoom. De opname van deze stof kan ook U.A.M. van Seht». G.G. Geyskti. J.C. Hom. El Dorhoul Mees. therapeutische consequenties hebben. CKn Phorm è Vier 1986. 39:6044, XI Bij veroordeling voor een /.waar misdrijf kan men 't best een levenslange Het clonidine withdrawal syndroom is een vrij sterke contraindicatie tegen het gebruik van dit antihyptttensivum. strul geven die verkort wordt bij verbetering van de mentaliteit. G.G. Geyskts. P. Boer. E.J. -
Home Dialysis
Have you thought about DIALYSIS at There is more than one HOME? way to treat kidney failure. Choosing your treatment is about helping you live your life. GETTING INVOLVED REALLY MATTERS You’ll feel more in charge if you take an active role in the decision. Your kidney team should tell you about all treatment options and the pros and What are the first steps? cons of each. But you make Learn about the different options for treatment of kidney failure. the choice based on your n Talk to the professionals who are treating you. needs, lifestyle, medical n Ask questions: conditions, and current • What treatments are done at home? level of kidney function. In • Am I eligible for home treatments? • How will my choice of treatment affect my order to make this decision, health and lifestyle? you need to learn about all • At this point in my kidney disease, is one choice better than another? the treatments. • Will one treatment better protect my remaining kidney function? Which one? 2 Where can you learn about your options? When you have kidney disease, a team of professionals (your kidney team) will help you understand how your choice will affect your life. Ask questions to be sure what the right option is for you. Discuss the things that are most important to you and any concerns or worries you may have. Visit the National Kidney Foundation website at www.kidney.org for helpful resources. You can also call the NKF Cares patient help line toll-free at 1.855.NKF.CARES (1.855.653.2273) or email [email protected]. -
An Interesting Presentation of Invasive Bladder Carcinoma As Pseudo
An interesting presentation of invasive bladder carcinoma as pseudo renal failure Uma apresentação interessante do carcinoma invasivo de bexiga como pseudo insuficiência renal ABSTRACT RESUMO Authors Ascites and oliguria with an increasing Ascite e oligúria com um nível crescente Ashwin Shekar1 serum creatinine level are often observed de creatinina sérica são frequentemente 1 Anuj Dumra in patients with acute renal failure. observadas em pacientes com insuficiência 1 Dinesh Reddy However, these symptoms are also renal aguda. Entretanto, esses sintomas 1 Hardik Patel noted in individuals with intraperitoneal também são notados em indivíduos com urinary leakage and can be mistaken for extravasamento urinário intraperitoneal acute renal failure. This rise in creatinine e podem ser diagnosticados como lesão 1 Sri Sathya Sai Institute of Higher in such patients is called pseudo renal renal aguda erroneamente. Este aumento Medical Sciences, Department of Urology, Prashantigram, failure and it happens by a process of de creatinina em tais pacientes é chamado Puttaparthi, Andhra Pradesh reverse peritoneal dialysis. In literature, de pseudo insuficiência renal e ocorre por 515134, India. the most commonly described condition um processo de diálise peritoneal reversa. that leads to this clinical picture is Na literatura, a condição mais comumente following a spontaneous or missed descrita que leva a este quadro clínico se dá bladder perforation. We, herein, report após uma perfuração vesical espontânea ou a case of carcinoma of the bladder that perdida. Relatamos aqui um caso de carcinoma presented with features resembling acute de bexiga que apresentou características renal failure, which later turned out to be semelhantes à insuficiência renal aguda, e pseudo renal failure due to intraperitoneal mais tarde se revelou uma pseudo insuficiência urinary extravasation from a forniceal renal devido a extravasamento urinário rupture. -
Dynamic Renogram
Dynamic Renogram What is a dynamic renogram scan? measure the number of gamma ray counts over time and plot the uptake, excretion and clearance Water soluble substances are predominantly data on a graph to form an objective analysis. cleared from the body via the kidneys. The rate at which waste products are cleared is a reflection of But injecting different chemical tracers that are the efficiency of the kidney and referred to as excreted in different ways by the kidney, we can kidney function. infer information about different aspects of kidney function i.e. DTPA is filtered and used to assess Many conditions can affect this function. Without filtration function; MAG3 is secreted by the kidney being able to clear waste products the body would tubular cells and used to assess tubular function eventually deteriorate and eventually one organ (and indirectly assess filtration function) and OIH system after another with begin to fail. It is combines both of these and allows us the assess a imperative that we are able to assess renal parameter called the effective renal plasma flow. clearance or function so that we can intervene and These parameters are all very important for your act in a timeous fashion. doctor. In patients with renal failure it also allows us to see What can I expect to happen? when dialysis will become necessary. In patients with kidney transplants it allows us to see when the Many things can affect kidney function that can transplant starts to deteriorate and oftentimes tell give spurious results. These include: us what is causing the deterioration. -
Office Cystoscopy Urinary Tract Infection Rate and Cost Before And
www.auajournals.org/journal/urpr Office Cystoscopy Urinary Tract Infection Rate and Cost before and after Implementing New Handling and Storage Practices Vincent Roth, Pedro Espino-Grosso, Carl H. Henriksen and Benjamin K. Canales* From the Department of Urology (VR, PE-G, CHH, BKC), University of Florida, Gainesville, Florida, Department of Surgery (VR, PE-G, BKC), Division of Urology, Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida Abstract Abbreviations Introduction: Based on 2010 American Urological Association recommendations our practice and Acronyms fl transitioned from sterile to high level disinfection exible cystoscope reprocessing and from sterile AUA ¼ American to clean handling practices. We examined symptomatic urinary tract infection rate and cost before Urological Association and after policy implementation. GU ¼ genitourinary Methods: We retrospectively reviewed 30-day outcomes following 1,888 simple cystoscopy en- HLD ¼ high level counters that occurred from 2007 to 2010 (sterile, 905) and 2012 to 2015 (high level disinfection, disinfection 983) at the Malcom Randall Veterans Affairs Medical Center. We excluded veterans who had recent ¼ instrumentation, active or recent urinary tract infection, performed intermittent catheterization, or had SUNA Society of complicated cystoscopy (dilation, biopsy etc). Patient/procedural factors and cost were collected and Urologic Nurses and Associates compared between groups. UTI ¼ urinary tract Results: Both cohorts had similar age (mean 68 years), race (Caucasian, 82%), comorbidities infection (cancer history, 62%; diabetes mellitus, 36%; tobacco use, 24.5%), and cystoscopy procedural indications (cancer surveillance, 50%; hematuria, 34%). Urological complication rate was low between groups (1.43%) with no significant difference in symptomatic urinary tract infection events (0.99% sterile vs 0.51% high level disinfection, p¼0.29) or unplanned clinic/emergency department visits (0.66% sterile vs 0.71% high level disinfection, p¼0.91). -
Peritoneal Dialysis in the 21St Century: an Analysis of Current Problems and Future Developments
J Am Soc Nephrol 13: S104–S116, 2002 Peritoneal Dialysis in the 21st Century: An Analysis of Current Problems and Future Developments RAM GOKAL Manchester Royal Infirmary, Manchester, United Kingdom. One major development in the field of kidney diseases in the of death on PD as compared with HD and by and large found 21st century will be in prevention of end-stage renal disease that mortality risk was equal for HD and PD in the various (ESRD). Basic research has made inroads into the understand- studies reported. After this analysis was the report of Bloem- ing of the mechanisms of progression of chronic renal failure, bergen et al. (2), which was based on the US Renal Data including the understanding of the functions of genes activated Systems (USRDS) data on prevalent patients (1987, 1988, and by renal damage. All this may well result in a major reduction 1989). This showed that PD subjects had a 19% higher risk of in the incidence of ESRD. The second important development mortality as compared with patients who used HD. This was will be in transplantation, which will constitute the mainstay of met with considerable consternation in the United States and ESRD treatment in the next century. The clinical introduction probably did the therapy a major disservice. Analysis from the of xenotransplantation and the cloning of one’s own organs via Canadian Organ Replacement Registry on patients starting one’s stem cells may well represent the major areas of replace- RRT between 1990 and 1994 showed that for incident patients, ment therapy. This will reduce dialysis as a method to support the survival with PD was better in the first 2 yr of treatment the main treatments. -
Antibiotic Prophylaxis in Peritoneal Dialysis Patients
Advances in Peritoneal Dialysis, Vol. 33, 2017 Antibiotic Prophylaxis in Miten J. Dhruve, Joanne M. Bargman Peritoneal Dialysis Patients Peritonitis is an important cause of morbidity, Discussion mortality, and technique failure in patients on peri- toneal dialysis (PD). The most effective approach Endoscopy in PD patients to peritonitis is prevention, which includes careful Several studies have looked at PD patients undergoing patient training and follow-up. Although peritonitis colonoscopy. Yip et al. (4) reported on 97 colonosco- as a result of contiguous spread of bacteria or fungi pies performed in 77 patients, observing a 6.3% rate of during invasive procedures, or as a result of seeding peritonitis after colonoscopy. Patients who were given of the peritoneum during bacteremia, is uncommon, prophylactic antibiotics did not develop colonoscopy- the likelihood of such spread is often predictable, and related peritonitis. The authors also noted that no in- the risk can be mitigated with antibiotic prophylaxis. crease in the rate of peritonitis was observed in patients Here, we describe the rationale for, and approach to, who underwent polypectomy. Wu et al. (5) reported a antibiotic prophylaxis in PD patients for the preven- similar post-endoscopy peritonitis rate of 6.4% and tion of infective episodes. noted that no patient prescribed prophylactic antibiot- ics developed peritonitis. In addition, several other Key words small case reports demonstrated the phenomenon of Antibiotics, peritonitis, prevention, bacteremia peritonitis after colonoscopy, with some even reporting a much higher rate of peritonitis (increased by a factor Introduction of 3 – 5) in patients undergoing polypectomy than in Peritonitis is the leading cause of technique failure those having nontherapeutic colonoscopy (5–9). -
Antibiotic Prophylaxis for GI Endoscopy
GUIDELINE Antibiotic prophylaxis for GI endoscopy This is one of a series of statements discussing the use of procedure. Endoscopy-related bacteremia carries a small GI endoscopy in common clinical situations. The Stan- risk of localization of infection in remote tissues (ie, infec- dards of Practice Committee of the American Society for tive endocarditis [IE]). Endoscopy also may result in local Gastrointestinal Endoscopy (ASGE) prepared this docu- infections in which a typically sterile space or tissue is ment, and it updates a previously issued document on breached and contaminated by an endoscopic accessory this topic.1 In preparing this guideline, MEDLINE and or by contrast material injection. This document is an up- PubMed databases were used to search for publications date of the prior ASGE document on antibiotic prophylaxis between January 1975 and December 2013 pertaining for GI endoscopy,1 discusses infectious adverse events to this topic. The search was supplemented by accessing related to endoscopy, and provides recommendations for the “related articles” feature of PubMed, with articles periprocedural antibiotic therapy. identified on MEDLINE and PubMed as the references. Additional references were obtained from the bibliogra- phies of the identified articles and from recommenda- BACTEREMIA ASSOCIATED WITH tions of expert consultants. When few or no data were ENDOSCOPIC PROCEDURES available from well-designed prospective trials, emphasis was given to results from large series and reports from Bacteremia can occur after endoscopic procedures and has been advocated as a surrogate marker for IE risk. How- recognized experts. Weaker recommendations are indi- fi cated by phrases such as “We suggest.” whereas stronger ever, clinically signi cant infections are extremely rare.