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Mental Depression) © 2019 JETIR January 2019, Volume 6, Issue 1 www.jetir.org (ISSN-2349-5162) CLINO-COMPARATIVE TRIAL OF CHARKOKTAMEDHYARASAYAN AND SHIRODHARA IN PATIENTS OF MANSIKAVASAD (MENTAL DEPRESSION) Dr. Shraddha Sharma* * Lecturer Department of Kayachikitsa. Pt. Khusilal Sharma Ayurveda Govt. Autonomous College and Institute Bhopal (M.P.) ABSTRACT Depression is extremely common as a disorder. It is estimated that 20 to 25% of women and 12 to 15% of men will suffer from a major depression during their life. Depression is normal feature of our hard life. Depression is the most common disease of psychiatry as cough and cold is in dept. of medicine. MedhyaRasayanaYog is one of such drug which is said to be Medhahitam, Rasayana, Vrsya and acts as mood elevators and promotes the sense of well being. The present clinical trial was conducted to evaluate the efficacy of Medhyarasayana and Shirodhara in 45 patients having symptoms of Depression. The effect of therapy was assessed adopting “Hamilton’s depression rating scale”. MedhyaRasayana and Shirodhara showed significant (P<.001) improvement in all parameters of Hamilton’s Depression Rating scale. It was inferred that most of the contents of the formulation of MedhyaRasayana are Medhya, Balya, Dhatupushtikara, Brimhaniya, Jivaniya, and Agnivardhaka. The drugs may act as adoptogens, antioxidants, immunostimulents, antistress, nootrophics, antidepressants, or may have other geriatrics benefits. Hence it was concluded that MedhyaRasayanaYog can be used as an alternative treatment to manage depression. Keywords: MedhyaRasayana, shirodhara, Stress. INTRODUCTION Depression is grouped under mood disorders or affective disorders, in which the primary and dominant characteristic is a change in mood consisting of a feeling of sadness, which may vary from mild desponding to the most object despair, mood disorder , affects the whole organism , feelings , energy , thinking , drive , personality and interest and tends to influence every sphere of personal life .chronically depressed individuals are among the least productive citizens and heaviest users of the medical services and are thus major economic burden to society. Its effect extends in varying degrees to family, friends and co-workers. Moreover, influence of depression has a wide sphere as stated by Caraka that vishadorogvardhanam1 and Susruta mention this disease as a manasvyadhi2. Being an alarming problem, Avasada needs upmost care and susruta mentions this disease as a manasvyadhi. Being on alarming problem, avasada needs upmost care and effective treatment. Generally management of psychic disorders in modern medicine is limited up to tranquilizers and sedatives and long use of which bestows hazardous side effects and drug dependency. All the electric mesuresunnativeral obviously get refused to body, which proves complete failure of such an artificial attitude in eradication of root cause of avosada so, it is essential to evaluate safe, easily available and economical drug, which potentiate the medha with additional vrsya effect. MedhyaRasayana3is a one of such drug which is said to be Medhahitam4, Rasayana5, vrsya and acts as mood elevator and promotes the sense of well being. It is a unique combination of four drugs mandukaparni, sankhapuspi, mulathi and gudhuchi which is consider as medhya as it works as nervine and brain tonic. JETIR1901615 Journal of Emerging Technologies and Innovative Research (JETIR) www.jetir.org 132 © 2019 JETIR January 2019, Volume 6, Issue 1 www.jetir.org (ISSN-2349-5162) Shirodhara is purity of liquid over the forehead or scalp. It helps to manage depression by activating nervous system to increase the secretion of neurotransmitters such as serotonin and dopamine. Shirodhara was done by medhyarasayanakwatha. MEDHAYA RASAYANA YOG • Medhaya rasayana yog is one of such drug which is said to be medhahitam,rasayana,vrisya and acts as mood elevator and promotes the sense of well being • Description of medhya rasayana yog is available in charak samhita ,1st chapter rasayana (3rd pada,karpratichiya pada) • It acts as nervine and brain tonic. • It stimulates the neurotransmitters of our brain. SHIRODHARA The name comes from the Sanskrit word shiro [head] and dhara [flow]. Shirodhara is an Ayurvedic method of treatment in which herbal oil, medicated milk or decoction is pored gently and steadily over fore head continuous stream a particular point from a definite height. Unique form of ancient therapy Specific height Specific period Continuously Rythmatically NIDANA (ETIOLOGY) 6 According to acharya charak, susruta and vagbhata. • Rajja and tamma manas doshes and manas bhava (Kama, krodha, bhaya, glani etc) are responsible for manas roga. according to Ayurveda nidana is A) Aharaja • 1.Tamasik and rajjasik ahara • 2.Vatadoshakaraka ahara • 3.Kaphavridhikaraka ahara B) Viharaja • 1.Tamasik and rajjasik karya • 2.Anavanchitta karya • 3.Asimitta karya JETIR1901615 Journal of Emerging Technologies and Innovative Research (JETIR) www.jetir.org 133 © 2019 JETIR January 2019, Volume 6, Issue 1 www.jetir.org (ISSN-2349-5162) • 4.Asamajik karya • 5.Vatadushtikaraka karya C) Rogaja • 1.Vatapradhana roga • 2.Kaphapropokapa roga • 3.Roga aggravates sadhaka pitta • 4.Chronic roga • 5.Manosararik raga D) Manasik • 1.Shoka,bhaya,krodha,dukha,ishya,chintta,diveysha,moha etc • 2.Mansik aghata • 3.Economic problem • 4.Family and social problems • 5.Sexual problems E) Others • Pragjyaappradha, purvajanam karya, disobeying of devta, rishi, gandharva, yaksa, guru, acharya etc. Modern etiology • 1.Genetic • 2.Biochemical • 3.Family problems • 4.Social AIMS AND OBJECT To evaluate the role of charkoktamedhyarasayana and shirodhara in mansikavasad Evaluation of changes in psychological state after using medhayarasayanayog. To provide a general observation of depressive patients METHODOLOGY • A clinical study for 21 days duration was carried out with three groups of patients to fulfill the aims and objects of the study. A special research Performa was prepared and data was statistically analyzed. There are 45 patients were selected are divided into three groups.(15 patients in each group) Group A • Medhyarasayanayog was given 10gm two times with milk for 21 days. Group B • Shirodhara was done by medhyarasayanakwath for 21 days. JETIR1901615 Journal of Emerging Technologies and Innovative Research (JETIR) www.jetir.org 134 © 2019 JETIR January 2019, Volume 6, Issue 1 www.jetir.org (ISSN-2349-5162) Group C • Medhyarasayana and shirodhara both are given for 21 days. SUBJECTIVE PARAMETERS A. PYSCHIC SYMPTOMS 1 Dukkhatvam 2 Anavastha Cittam 3 Glani 4 Asiddhi Bhaya 5 Visada 6 Atmana Asktata 7 Kheda 8 Alpa Nidra 9 Suicidal Tendencies 10 Ati chinta B. SOMATIC SYMPTOMS 1 Karmesu Apravritti 2 Aaruchi 3 Bharchinata 4 Mala avarodha 5 Swasa Karchichata OBJECTIVE PARAMETER 1 CBP with ESR 2 Sugar Test OTHERS 1 B.P. 2 Body weight 3 Pulse 4 Temperatures Result and observation JETIR1901615 Journal of Emerging Technologies and Innovative Research (JETIR) www.jetir.org 135 © 2019 JETIR January 2019, Volume 6, Issue 1 www.jetir.org (ISSN-2349-5162) JETIR1901615 Journal of Emerging Technologies and Innovative Research (JETIR) www.jetir.org 136 © 2019 JETIR January 2019, Volume 6, Issue 1 www.jetir.org (ISSN-2349-5162) S.NO Effect of therapy Group A Group B Group C Pt. % Pt. % Pt. % 1 Markedly improved - - 2 13.32 3 20 2 Improved 9 60 9 60 10 67.67 3 Mildly improved 6 64 4 26.67 2 13.33 4 Not improved ---- ---- ------ --- ----- ---- To 15 100 15 100 15 100 tally Discussion The effect of therapy in 45 patients are in three groups are mentioned as below Group A Out of 15 patients, 9 patients (i.e. 60/) are improved and 6 patients (40/) are mildly improved. Group B Out of 15 patient,2 patients(i,.e13.32/)are markedly improved and 9 patients(60/) are improved whereas 4 patients (i.e. 26.67/) are mildly improved. Group C Out of 15 patients, 3 patients (i.e. 20/) are markedly improved and 10 patients (i.e. 66.67) are improved whereas 2 patients (i.e. 13.33/) are mildly improved. MODE OF ACTION MEDHYA RASAYANA . Medhya rasayana yog is a combination of four drugs . Mandukaparni, mulathi, sankhapushpi and guduchi. JETIR1901615 Journal of Emerging Technologies and Innovative Research (JETIR) www.jetir.org 137 © 2019 JETIR January 2019, Volume 6, Issue 1 www.jetir.org (ISSN-2349-5162) . The medhya rasayana are known to be beneficial to improve the intellectual e.g. mandukparni swaras, yashtimadhu churna with ksheer, guduchi swaras and shankhapushpi kalka.medhya rasayana drugs are used for prevention and treatment of mental disorders of all the age groups. These drugs promote the Intellect (Dhi), Retention power (Dhriti), memory (smriti). Unfortunately modern medicine based psychoactive drugs have met with limited success in treatment of various neurological and psychiatric disorders due to multi-factorial nature of these diseases. This review discusses about medhya rasayanas as great players for prevention and management of age related cognitive decline. PROBABLE MODE OF ACTION OF SHIRODHARA 1. TRANQUILIZING EFFECT Chemical constituent of medicated oil may acts as a neurotransmitter (for ex. serotonin) as deficiency of certain neurotransmitter can be checked hypothetically , if oil circulate into the brain cortex as explained by Johnson while treating the patient of angina by nitroglycerin. 2. EFFECT ON AUTONOMIC NERVOUS SYSTEM Shirodhara may also have alpha adrenergic blocking effect and can thus block certain actions of adrenaline and noradrenaline.shirodhara
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