The Academic Centre for Dentistry Amsterdam

ANNUAL RESEARCH REPORT 2016

Annual Research Report 2016

Edited by : H.S. Brand and F.M. Meijer, ACTA Design cover : Facilitaire dienst, ACTA Cover : Department of Oral and Maxillofacial Surgery AMC, ACTA

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3 Annual Research Report 2016

CONTENTS page

INTRODUCTION 5

REPORT OF THE DEAN 6

The Research Institute ACTA 6 Evaluation of the research program 6 Summary of research output and input 7 Societal impact 10 Management 11 PhD students 12 Points of attention 14 Conclusion 14

DESCRIPTION OF PROGRAMS AND RESULTS

Oral Infections and Inflammation 15

Oral Regenerative Medicine 55

Other research, including education related research 102

APPENDIX: Impact factors of SCI journals for ACTA publications 105 Name Index 106

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INTRODUCTION

ACTA is the combined Faculty of Dentistry of the University of Amsterdam (UvA) and the VU University Amsterdam. ACTA has a unique position in the Netherlands, being a combined faculty of two universities since 1984. The boards of both the University of Amsterdam and the Vrije Universiteit Amsterdam share the responsibility for the research at ACTA. Research at ACTA is organized in the ACTA Dental Research Institute.

The annual report starts with chapters containing the annual survey of the dean, and overviews of the scientific activities. As in preceding years the scientific performance is subsequently presented for each programme. Detailed information is given of dissertations, scientific publications in refereed journals, other scientific publications, professional publications, indicators of esteem, collaborations and societal impact.

In 2014 an international review committee evaluated the two research programs of ACTA. Both programmesOral Infections and Inflammation and Oral Regenerative Medicine received a very good to excellent rating.

An overview of the scientific output in 2016 is presented in Table 1. During the last decade, the output has increased considerable. The number of scientific publications and the impact factor sum remained high in 2016. The number of PhD theses continued to increase and an all time high number of 25 PhD theses were published and defended in 2016.

Research Institute ACTA prof.dr. A.J. Feilzer dean dr. T.J.M. van Steenbergen co-ordinator of research dr. H.S. Brand co-ordinator of research

Address ACTA Gustav Mahlerlaan 3004 1081 LA Amsterdam The Netherlands

tel: +31-20-5980641 e-mail: [email protected]

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REPORT OF THE DEAN

The Research Institute ACTA  mission statement Dental research at ACTA focuses on the study of health and diseases of essentially all tissues of the oral cavity, the masticatory system and of oral fluids. Besides infectious diseases like dental caries, periodontal and periapical inflammatory processes, and inflammatory processes around dental implants, attention is paid to the development, function and regenerative capacities of the hard tissues, pain and dysfunction of the masticatory system, and diseases of salivary glands and oral mucosa. It is the general aim to improve strategies for diagnosis, treatment indication and treatment planning as well as prevention of diseases, functional repair of the affected tissues in and around the oral cavity and evaluation of therapies developed to treat patients. Moreover, we aim to gain insight in the aetiology and pathology as well as the risk factors involved in these diseases. In our attempts to fulfil this mission we aim to establish: - integration of the clinical sciences with fundamental disciplines - education and further academic training of post-graduate and PhD-students - knowledge transfer and improvement of the quality of the research in ACTA with special attention to the translation of the results into applications in clinical dentistry. To this end there is a vivid interaction with professional dental organizations and industries.

 positioning of the research institute National position. ACTA comprises the combined Faculties of Dentistry of the University of Amsterdam and the Vrije Universiteit Amsterdam. The ACTA Research Institute is the only institute for research of the faculty. Research programs. From 2011, ACTA research has been organized into the two research programmes (see below). Next to these two major programmes, some limited other research is performed, which is mainly education-related. The programme Oral Infections and Inflammation (OII) focuses on (i) the aetiology, prevention and therapy of oral infections such as caries, periodontal and endodontic infections, on (ii) oral inflammatory processes, protective functions of saliva, oral cancer and on (iii) the definition of a normal, healthy oral cavity including psychosocial factors. The programme Oral Regenerative Medicine (ORM) focuses on (i) the biological process of adaptation and repair of teeth, bone, mucosa and periodontium, on (ii) the biocompatibility of dental materials, and on (iii) regenerating damaged oral tissue by means of stem cell therapy and/or tissue engineering techniques, taking into account the mechanical threats of the masticatory system. Untill December 31s 2016, ACTA research on oral regenerative medicine was also included in the interfaculty MOVE Research Institute Amsterdam, a collaboration between the faculty of Behavioural and Movement Sciences, the VU University Medical Centre (VUmc) and ACTA.

 description of output, leading scientific journals in the field Within both research programmes considerable differences exist in the approaches used; yet, both range from fundamental medical-biological to clinical-applied science. This is reflected by the type of scientific journals in which ACTA researchers publish. Some groups primarily present their findings in journals read in the dental research community, while others also aim for the general medical-biological literature.

Evaluation of the research program  external evaluation SEP external evaluation. In 2014 an external evaluation of dental research of ACTA was completed according to the Standard Evaluation Protocol designed by the VSNU. The two research programs of ACTA, Oral Infections and Inflammation and Oral Regenerative Medicine were evaluated separately with respect to quality of the research, relevance to society and viability. The committee concluded about the program Oral Infections and Inflammation: The quality of research in this programme was considered excellent. Many strong publications from the OII group have had a considerable impact in the field of dental research and have influenced opinion development on these topics in the broader scientific community. The relevance of the group’s research to society was considered to be very good. Collectively the future of the programme was considered to be very good. The committee concluded about the program Oral Regenerative Medicine: Because of the future trajectory and promise provided in particular by the increased integration of cell biology approaches into scaffold

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development and prosthodontics/ implantology research, the research quality of the ORM programme was considered to be excellent. The ORM programme’s impact on society is considered to be very good. While there are some structural organizational issues that need to be resolved to ensure further integration, research success and ongoing productivity, the group’s viability is considered to be very good. The committee gave a number of valuable recommendations that will be elaborated in the next years. to further strengthen the research at ACTA. For more details about this evaluation we refer to the assessment report of the committee. In spring 2017, an external evaluation of both Research Priority Grants of the University of Amsrerdam will be performed. Citation analysis. In 2013, the CWTS in Leiden has performed a bibliometric analysis of the ACTA scientific publications over the years 2001-2011. One of the goals of this study was to identify possible benchmarks. These benchmark candidates were investigated in more detail and compared with the performance of ACTA. The conclusions of this study are as follows: In this study we developed and applied a method to identify benchmark candidates for institutes with a non- mainstream research profile. These benchmarks are used to position the performance of ACTA. The outcome of this study shows an important role of ACTA in terms of output. ACTA has published an impressive amount of papers during the period studied (1,142 papers). Also the amount of number of citations received is very high (4,667) as well as the number of publications in the top 10% most highly cited (P_top10). It should be noted, however, that the latter two are size-depended: the more you publish, the more citations you will receive. If we look at the impact (MNCS and PP_top10, citations per publication normalized by field), ACTA is among the middle group. Still the impact is well above world average (10%).

Summary of research output and input

Table 1. Comparison of research indicators 2004-2016

Year 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

Dissertations 12 11 11 12 13 6 18 15 13 18 13 15 25

Refereed publications 170 166 189 185 214 216 196 199 208 250 255 286 272 First author from ACTA 111 130 131 117 159 132 105 103 117 127 126 161 140 Other scientific publications 8 17 13 6 24 12 18 15 14 16 18 31 22 Professional publications 91 99 114 113 98 168 164 169 132 159 167 175 131 Publications for general public 8 14 9 12 9 13 31 3 Impact factor sum 273 322 344 354 435 509 434 503 493 696 656 745 686

Personnel WP 1 49.4 46.0 46.5 50.3 43.4 40.8 36.7 36.2 39.5 42.2 40.6 38.6 46.2 WP2 6.6 4.8 7.9 7.8 9.6 7.0 7.8 10.1 9.4 6.3 5.9 4.9 3.9 WP3 7.7 6.7 7.4 6.5 5.4 12.9 13.5 14.4 17.6 19.6 19.6 28.1 27.8 Guests 1.9 2.2 4.2 4.3 3.6 pm pm pm pm pm pm pm pm Total personnel 65.6 59.8 66.1 68.7 62.1 61.6 57.9 60.7 66.5 68.1 66.1 71.6 77.1 wp1 = academic personnel funded by 1st source in fte; this includes direct funding by the university wp2 = academic personnel funded by 2nd source in fte; this includes research grants obtained in national competition from NWO, STW and KNAW wp3 = academic personnel funded by 3rd source in fte; this includes research contracts for specific projects obtained from external organizations, such as industry, governmental ministries, European Commission and charity organizations

 long time performance Dissertations (PhD theses). The performance of the research institute over a longer period is shown in Table 1. These data show that the number of dissertations per year has fluctuated between 6 and 18. This reflects variations in external collaborations, such as non-ACTA employees receiving a PhD from our universities and tenure staff members finishing their PhD. In 2016, 25 dissertations were accomplished.

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PhD performance. The percentage of PhD students that finished their thesis averages 92 % over the last 20 years, and the mean time period between start of employment and defending the thesis is 4.6 years. This figure is corrected for the 0.6 to 0.8 fte employment of several PhD students and for long leave of absence (e.g. maternity and illness) of some PhD students. Scientific publications. The main attention in the research assessment at the individual and program level is given to publications in scientific journals with a peer review referee system. This category has increased considerable since the turn of the century, and resulted in a stable high output since 2013. In 2016, again a high number of 272 refereed publications was obtained. The majority of these publications were published as open access (Gold/Hybrid 29%, Green 32%). The average quality of the publications has also improved during the last two decades, as indicated by the concominant increase of the impact factor sum (Figure 1). Professional publications. ACTA scientists are very active in communicating their research findings not only to the scientific community, but also to professionals. The number of professional publications in 2016 was 131.

Figure 1. Impact factor sum of ACTA publications, scientific publications in refereed journals, professional publications and total scientific personnel in fte. 800

700

600

500 IF sum ref publ 400 total fte

300 prof publ

200

100

 notable events in 2016 Publications in high ranking journals. Outstanding contributions for the year 2016 were publications in high ranking biomedical journals, i.e. Trends in Biotechnology (impact factor 12.1), Proceedings of the National Academy of Sciences of the United States of America (impact factor 9.4), Oncogene (impact factor 7.9), and Schizophrenia Bulletin (impact factor 7.6). ACTA scientists also published 16 papers in the top 10% journals in dentistry. Impact factors. In addition to the output indicators given, the percentage of papers in high impact journals in the field gives valuable information. ACTA published in total 272 scientific papers in refereed journals, of which 253 in journals with an impact factor (SCI journals). 41% of these 253 papers appeared in journals belonging to the field Dentistry, Oral Surgery and Medicine. 15% of all publications were in the top 10% of the journals, 42% in the top 25% and 80% in the top 50% (Table 2). This means that, as in previous years, a relatively large number of publications were published in the top journals in the field, both in dental and in non-dental journals.

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Indicators of esteem. On a personal level a number of ACTA employees rank in the top of the international dental community, as determined by the various indicators of esteem, such as editorships, invited lectures, and congresses organized. In 2016 a total of 9 awards were received by ACTA scientists for their achievements. For more details we refer to the description of the two research programs. Grants. In 2016, the successful participation of ACTA in the nationally funded and oriented Top Institute Food and Nutrition (TIFN) was completed. In the TIFN theme ‘Oral Health’, which started in 2011, world players in the oral care industry, the chewing gum industry, flavour industry, food industry and (oral) care appliances industry collaborated with ACTA and with the Netherlands Organization for Applied Scientific Research (TNO). At this moment two ACTA PhD students are funded by the large EU-MUNDUS project MOVE-AGE. In 2013 the large Marie Curie ITN EU project Euroclast was granted by the EU. This project is coordinated by ACTA and involves participation of seven academies and two industrial partners and a total of 11 PhD students. In 2015, the EU Horizon 2020 Research Program awarded 6 million Euro’s for the project ADVOCATE – Adding value to oral care. A grant was obtained in collaboration with the Radboud University Nijmegen from the Dutch Cancer Society to explore oral complications in cancer patients (KWF-HOME). The Netherlands Organisation for Health Research and Development (ZonMw) granted a project for the development of biomimetic bone substitutes (BIOBONE).

Table 2. Percentage of publications in different quartiles of dentistry and non-dental journals in 2016

dentistry journals non-dental journals all journals

numbers percentage numbers percentage numbers percentage top 10% 16 15 % 23 15 % 39 15 %

Quartile 1 30 29 % 78 52 % 108 42 %

Quartile 2 39 38 % 55 37 % 94 37 %

Quartile 3 24 23 % 15 10 % 39 15%

Quartile 4 11 11 % 1 1 % 12 5 % total 104 100% 149 100% 253 100%

 assessment at the program level In general, both research programs have performed comparable in terms of parameters like input and output during the past (personnel, PhD students, publications, dissertations etc). In 2016 the output of the OII programme was higher than the ORM programme, in particular with respect to professional publications, see Table 3. Other research (OWI), not related to the two programs, is limited both in terms of input (personnel and budget), and of output. Despite the very limited financial input by ACTA, this education related research is considered valuable.

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Table 3. Summary of the number of publications, impact factor sum and academic personnel in fte

Program Dis Ref publ OSP PP PGP IF wp1 wp2 wp3 wp tot OII 15 149 (65) 16 95 3 426 24,85 0,50 12,20 37,55

ORM 15 135 (63) 6 59 - 368 20,75 3,40 15,60 39,00

OWI - 1 (1) - 1 - 3 0,30 - 0,25 0,55

ACTA* 25 272(140) 22 131 3 686 45,90 3,90 28,05 77,10

This table summarises the number of scientific publications in refereed journals, the number of other scientific publications, and the number of professional publications. Also the personnel involved in full time equivalent (fte) and the impact factor-sum (IF-sum) are included in this table. The IF-sum was calculated for each program by adding together the impact factor values of all 2016 publications. Dis = number of dissertations Ref publ = number of scientific papers in refereed journals. Between parentheses is the number of first authors belonging to the program in question OSP = other scientific publications (international, refereed) PP = professional publications PGP = publications for the general public IF = sum of impact factors as indexed by ISI. wp1 = academic personnel funded by 1st source in fte wp2 = academic personnel funded by 2nd source in fte wp3 = academic personnel funded by 3rd source in fte wp tot = all academic personnel in fte OII = Oral Infections and Inflammation ORM = Oral Regenerative Medicine OWI = Education Institute and other research * ACTA = the total number of dissertations and papers reflects the total for ACTA; a dissertation or paper was counted only once; the total impact factor sum is not a summation of the data from each program

Table 4: fte of staff and PhD students (see table 2) by type of position

Program Staff PhD students Total 1st 2nd 3rd 1st 2nd 3rd OII 17,40 0,20 7,20 7,45 0,30 5,00 37,55

ORM 12,75 1,10 5,20 8,00 2,30 10,40 39,00

OWI 0,10 - 0,10 0,20 - 0,75 0,55

Total 30,25 1,30 12,50 15,65 2,60 15,65 77,10 OII = Oral Infections and Inflammation ORM = Oral Regenerative Medicine OWI = Education Institute and other Research

Societal impact  impact on teaching and dental care The prime societal values of a strong research program in a dental discipline are the effect on teaching and on dental care. The research improves the quality of teaching given at ACTA, both for undergraduate students, graduate students, students participating in the post-initial specialist courses, and for PhD students. New findings and concepts are included in the curriculum at ACTA, but are also presented to dental practitioners at frequently held education activities, e.g. Quality Practice. The Research Institute participates in the ACTA curriculum by offering scientific training to all ACTA dental students. The societal impact of the research of ACTA is also focussed on the influence on patient care, both within ACTA and externally. Research on different

10 Academic Centre for Dentistry Amsterdam main areas of interest contributes to improved prevention, diagnosis and treatment of relevant patient groups. The high number of professional publications contributes to this societal impact. In this annual report the societal impact of each research program is described in more detail in the respective chapters.

 functions in the scientific and professional community ACTA employees take an active role as executives in international scientific organizations (87 international functions), as members of editorial boards of scientific journals (61) and in being leading in 'wetenschappelijke verenigingen' of researchers and dental practitioners in the Netherlands. Furthermore, the societal impact is evident from the organization of symposia and conferences in the Netherlands and abroad, presentations for dentists, medical specialists and patient groups, memberships of advisory councils, and frequent contacts with the industry. In addition many scientists are also practising as dentists in specialized clinics at ACTA or in the Amsterdam region. Obviously the societal impact of their activities, individually as clinically active professionals and leading among their peers, should be acknowledged. The societal impact is also evident from the relatively large number of 131 professional publications. Some ACTA researchers also wrote popularising publications aimed at a more general audience. Several research findings were high lightened in the general press.

 invited lectures and congresses organized In 2016 ACTA researchers have again contributed actively in internationally held meetings, workshops and symposiums, both as organizers and participants. A total of 105 lectures were given as ‘invited speaker’ at international congresses and symposia. In addition a large number of presentations were given at international congresses after selection on submission of abstracts and during congresses and symposia for a Dutch or international audience. Due to this large number, congress abstracts are not listed in this annual report. A total of 18 international meetings were organized by ACTA scientists.

Management  finances The overall budget of the research institute is divided into a part controlled directly by the directorate and another part that is allocated to the departments. The institute budget (senso stricto) of k€ 817 is used for the management of the institute, salaries of PhD students, for travel allowances of PhD students, for the organization of courses for PhD students and for printing PhD theses. The research budgets for the departments (in total being k€ 3298) are distributed based on a model containing several parameters, such as external peer review, bibliometric data over the last 5 years, education, PhD theses and external funding. In addition, standard bench fees are issued for PhD students appointed by the research institute. In addition to the university budget (1st source) ACTA scientists were involved in many research projects with external funding. The total amount of research grants (2nd source) was k€ 215, and the total amount of research contracts (3rd source) was k€ 2053.

 personnel The directorate of the institute comprises: prof.dr. A.J. Feilzer, dean and director of research ad interim p.m. dr. T.J.M. van Steenbergen, co-ordinator of research 0.55 fte dr. H.S. Brand, co-ordinator of research (started May 2016) 0.40 fte mrs. F.M. Meijer, secretary 0.60 fte dr. J.A.M. Korfage, research technician 0.15 fte

The activities of the research institute directorate consist of organizing scientific meetings with presentations of PhD students, the screening of new research projects, the day-to-day interaction with graduate students on practical matters regarding their position, compiling the annual research report, the planning of graduate courses, allocating budgets for research to the departments, controlling the institutes budget and dealing with general correspondence on research issues with UvA, VU etc.

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PhD students The ACTA PhD training program is organized in the ACTA Graduate School of Dentistry (AGSD). As ACTA has currently no research master training, the AGSD is limited to the PhD program.

 PhD student appointments In Figure 2, the number of new PhD students at ACTA is shown from the years 1991 to 2016. 26% of the current PhD students has a foreign nationality. In 2016, 9 new PhD students were appointed by ACTA which is similar to the long-term average number. Three of these students have been appointed by the research institute. More than half of all PhD students have a dental background (see Table 5). Of all PhD students about 70% is female.

Figure 2. Numbers of new ACTA PhD students from the Netherlands and other countries

14 12 10 Foreign 8 Dutch

6 numbers of PhD students PhD of numbers 4 2 0

year of entry

Table 5: PhD students by type of undergraduate training program dentistry dentistry biology / psychology medicine other total Dutch other chemistry OII 31 19 10 5 9 11 85

ORM 22 26 16 1 14 4 83 - OWI 2 1 - - - - 3

Total 54 45 26 6 23 16 171 OII = Oral Infections and Inflammation ORM = Oral Regenerative Medicine OWI = Education Institute and other research

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 PhD Courses The following courses are organized for PhD students: Scientific Integrity, Dentistry for non-dentist PhD students, Writing and Presenting in English, Methodology and Statistics and Oral Biology. Dentistry is a multidisciplinary science and the background of the PhD students of ACTA is diverse. Therefore, most PhD students also follow external courses on specific research areas, organized by research schools in other disciplines.

 PhD thesis duration and completion rate Attention has been paid to the problems related to the social security benefits of PhD students and the time that PhD students need to finish their thesis. The mean time between start of the PhD project and the defence of the thesis within ACTA amounts 4.6 years.

Figure 3. Mean duration of completing the thesis of ACTA PhD students related to the year of entry

6,5

5,5

years 4,5

3,5

year of entry

Over the last 20 years, about 90 % of all PhD students in ACTA completed their thesis (Figure 4). The PhD programma was evaluated by an external review committee in 2014. They concluded: Following queries about the infrastructure and core facilities, there was strong and unanimous agreement on the effectiveness of the ACTA programme to provide excellent PhD training. The students indicated that their programmes were well- organized and were well-supported to enable fulfilment of their research goals.

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Figure 4. Percentage of ACTA PhD students completing their thesis related to the year of entry

120

100

40 percenatge 20

year of entry

Points of attention  HRM and retirement In the coming years several full professors who were active in 2016 will retire, thus giving the opportunity to appoint highly qualified researchers with a focus on one of the two programmes. The number of persons involved in research on university budget (1st source) increased compared to 2015, while the fte scientific personnel on grants (in particular 3rd source) showed a slight decrease.

 PhD training The duration of the PhD programme is, like elsewhere in The Netherlands, in general 4 years full time. PhD students with an employee status are generally employed for 4 years full time or for 5 years during 4 days a week. PhD students funded by EU grants are appointed for 3 years. Recently, it has been decided that future PhD students funded by ACTA will also be appointed for 3 years. The research institute will continue its strategy, concentrating on the two main research programmes. New PhD positions will be reserved for high quality projects which focus at the integration of fundamental and clinical science. According to the PhD regulations of both universities the course programme has been formalized with 30 ECTS points and examinations. The integration between the PhD training programme and the post-graduate clinical training programmes for dental specializations, which is limited now to the courses on statistics and oral biology, will be intensified. Following a course on Scientific Integrity is obligatory for all PhD-students

Conclusion The research at ACTA has always been characterized by a wide range of different topics that covered most dental disciplines. The present policy is to focus on the two specific research areas with an excellent performance. The analysis of the various parameters of performance shows that the research at ACTA is, despite of budget restrictions, increasingly improving. Future performance will be dependent among others from the success in obtaining 2nd and 3rd source grants.

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Oral Infections and Inflammation

Program Leaders

Prof.dr. B.G. Loos ACTA Gustav Mahlerlaan 3004 1081 LA Amsterdam Tel: +31-20-5980558 E-mail: [email protected]

Prof.dr. W. Crielaard ACTA Gustav Mahlerlaan 3004 1081 LA Amsterdam Tel: +31-20-5980558 E-mail: [email protected]

Full professors

E. Bloemena J.J.M. Bruers J.M. ten Cate T. Forouzanfar

G.J.M.G. v.d. Heijden A. de Jongh B.J.F. Keijser J. de Lange

C. van Loveren F.R. Rozema E.A.J.M. Schulten L.E. Smeele

E.C.I. Veerman G.H.W. Verrips I. van der Waal G.A. van der Weijden

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Introduction

Oral Infections and Inflammation The oral cavity is one of the most infected parts of man. We hardly understand why most people are completely healthy with at least a thousand different species of microorganisms in billions of numbers present in the mouth, while other individuals develop oral infectious diseases, chronic inflammatory processes and other pathologies, including oral cancers. The central research theme “Oral Infections and Inflammation” (OII) focusses on the pathophysiology, epidemiology and (psycho)social aspects of oral infections and inflammation and prevention and treatment of those, as well as defining and understanding the healthy oral cavity as a complex ecosystem, with applications far beyond the mouth alone. The four topics in this program interact with each other and can be depicted in the schematic diagram below.

Research objectives 1) The healthy oral cavity and good systemic health. Oral health is an essential part of the general health of each person during his or her life. Poor oral health, oral infections and inflammation, oral cancer and other oral pathology, can lead to major health risks and might affect the progression of cardiovascular diseases, diabetes, cancer and cancer dissemination, systemic chronic and acute infections and vital organ failure. Poor oral health leads to a lower quality of life and economic hardship. In collaboration with several industrial partners, the Netherlands Organization for Applied Scientific Research (TNO) and the Top Institute of Food and Nutrition (TIFN), we work on defining normal oral health using a molecular biology approach (-omics). At the same time, we investigate the systemic effects of oral infectious processes in relation to atherosclerotic cardiovascular disease and diabetes, both by literature review and with an intervention trial (focus is mainly on changes in the microbiome and in biomarkers of the named systemic diseases). 2) Innate immunity (cells/saliva), and susceptibility for caries and periodontal diseases. Studies into the role of saliva and innate immune cells (oral PMN) in the maintenance of oral health have a prominent place. Several salivary proteins have strong antimicrobial capabilities and have important proteinase inhibitory actions. Synthetic peptide analogues of salivary histatins are tested as broad spectrum antibiotics. The influence of saliva on the interaction of oral microorganisms with oral epithelial cells and the in vitro wound healing capacities of salivary components are also being investigated. We find PMN in rinsing samples and they have antimicrobial functionality and are thought to have an essential role in maintaining oral health. For periodontal diseases, we collaborate in a self-supported European consortium to identify genetic variations, and we model periodontal disease as a complex system (environmental, life style factors, systemic factors, randomness).

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3) Epidemiology and pathophysiology of oral cancer. Forms of oral cancer, precursor lesions of oral cancer, particularly leukoplakia, and salivary tumours are studied. Amongst others, the prognostic value of molecular markers is examined with regard to the malignant transformation of leukoplakia, and the role of the human papilloma virus (HPV) has been studied. Poor oral health with its concomitant increase in the oral bacterial load, can predispose for oral cancer. Oral infections are independently associated with oral (pre)cancers. Therefore, not only the traditional risk factors smoking and alcohol usage play a role in oral cancer, but also oral bacteria, yeast and virus. Laboratory and clinical studies are ongoing. Intervention in the precursor lesions of oral cancer, particularly leukoplakia, may prevent the development of frank malignancies. Also other odontogenic tumours are studied, with emphasis on ameloblastomas and keratocystic odontogenic tumours. Characterization is also included of salivary gland tumours at the genomic and protein level. 4) Prevention and therapy of oral infections and inflammation. The knowledge that oral infections may have systemic effects, provides a fundamental basis for new cost- effective prevention programs as well as economic and social spin-off product-innovations in the food and oral care products and dental restorative materials. The dental and medical profession is (re)educated with new knowledge on the fundamentals of normal oral health and the risks of having chronic oral inflammatory processes. The formation, structure and properties of oral and dental biofilms are studied, also in relation to tooth and implant structures. In addition, new antimicrobials and peptides have come into focus as caries and periodontitis preventive agents. Studies into the most effective clinical measures to prevent inflammation of the gingiva and mucosa and to control oral health are being conducted, including substantial efforts to reach clinical standards for evidence based dentistry. Part of successful prevention measures is to improve and to maintain the well-being of both regular dental patients and subgroups of patients suffering from (extreme forms of) anxiety or (anticipated) pain or from physical/mental handicaps.

The researchers within the theme Oral Infections and Inflammation have an international prominence in the field of oral health and have acquired a global leadership role in the emerging field of complex ecosystems such as the oral cavity; thus understanding of oral infections, inflammatory processes, oral cancer and the definition of a normal, healthy oral cavity including psychosocial factors. We have been awarded a grant from the University of Amsterdam (UvA) (starting date 1-1-2011) and we demonstrated the multiplier effect (both on the academic as well as the economic aspects) by participating in the Top Institute of Food and Nutrition (TIFN) (contract signed December 2011, first year research in 2012, ending date December 2016).

Results obtained Preclinical studies  In an in vitro study on the anti-erosive effects of phytosphingosine (PHS) it was shown that PHS significantly reduced tissue loss. Toothpastes containing Sn2+ and F- ions were significantly more effective compared to PHS.  Diffusion of antimicrobials in multispecies biofilms were evaluated in a new biofilm model.  In order to evaluate the ability of dental materials to prevent and to arrest caries lesions in approximal surfaces in contact with occlusoproximal restorations, a systematic review and meta analysis was carried out. The results showed that in laboratory studies, GIC shows better ability to arrest caries lesions in approximal adjacent surfaces, but this ability was not confirmed in longitudinal clinical trials.  We previously established that osteoclasts can be cultured from three distinct mouse bone marrow precursor sets: early blasts, myeloid blasts and monocytes. Now their susceptibility to inflammatory cytokine IL-1beta was established. It was shown that the less differentiated lineages early blast and myeloid blasts responded by increased osteoclast formation and that monocytes were relatively indifferent. Early blasts showed higher proliferation, myeloid blasts responded by enhanced and earlier fusion of precursors.  Inflammatory cytokines such as TNF-alpha accumulate in the inflamed periodontium, leading to osteoclast activation and periodontal bone loss. In an attempt to isolate possible players in this process, osteoclast formation by periodontal ligament fibroblasts and peripheral blood, containing osteoclast precursors were incubated with infliximab, a widely-used TNF-blocker. Infliximab potently blocked the formation of cell clusters preceding osteoclast formation as well as the formation of osteoclasts.

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 It has previously been established that different categories of monocytes, the classical, intermediate and non-classical monocytes, can give rise to osteoclasts. Inflammatory cytokines, such as IL-17, a key-player in periodontitis, may further activate osteoclast precursors. Especially intermediate monocyte-derived osteoclasts were more active in the presence of IL-17.  For Workpackage 5 Field Studies of the ADVOCATE project, which is funded through the EU Horizon 2020 program, strong collaborative workstreams in Germany, Denmark and the Netherlands have been build together with project partners and general dental practitioners .  The project Research Agenda Oral health aims at establishing a national oral health outcomes research agenda. The long list of topics as suggested by general dental and oral health care practitioners has become available. Topics of this list will be prioritized by dentists and oral health care practitioners.  We have characterized the immunomodulatory and anti-inflammatory activities of chicken cathelicidin-2 derived peptides in vitro.  The anti-erosive effects of PHS were established in a pH cycle model.  The use of magnetic beads for optimization of bead-based diagnostic tests has been evaluated.  It was found that PAI-2/SerpinB2 inhibits the proteolytic activity in a P. gingivalis-dominated multispecies bacterial consortium.  We developed Valine-Leucine-Lysine containing peptides. After proteolysis by bacterial enzymes, these are incorporated in the bacterial cell wall.  We have developed novel synthetic sortase A substrates that are incorporated with high efficacy into the S. aureus cell wall.  We continued to study the inflammation-driven process of osteoclastogenenesis, from monocytes to pre- osteoclasts, to osteoclast and multinucleated giant cells; this is the field of osteoimmunology and was carried out as preclinical studies in mice or with ex vivo materials. Various sources of bone-samples showed a differential capability for osteoclast generation and functionality. The role of periodontal ligament cells in inflamed situations or normal situations was investigated, again by ex vivo cell cultures or mouse models.  A novel compound to maintain a healthy oral plaque ecology in vitro was discovered and characterized.  It was shown that nitrate and the origin of saliva influence the composition and short chain fatty acid production of oral microcosms.  We explored a new algorithm, metaModules, which identifies key functional subnetworks in microbiome- related diseases.  We studied and characterized the red and green fluorescence from oral biofilms.  A systematic review and meta-analysis on the prevalence and nature of fungi in root canal infections was compiled.  It was shown that a single nucleotide change in the promoter mutp enhances fluoride resistance of Streptococcus mutans.  Epithelial cell detachment by Porphyromonas gingivalis biofilm and planktonic cultures was characterized.  It was shown that in mixed biofilms Enterococcus faecalis benefits from a calcium hydroxide challenge and culturing.  A systematic review with meta-analysis on psychosocial correlates of oral hygiene behaviour in people aged 9 to 19 was compiled.  We showed interspecies interactions between Clostridium difficile and Candida albicans.  A study on Candida albicans in multispecies oral communities was showed that Candida albicans in oral biofilms could prevent caries.  A study on fine-tuning covalent inhibition of bacterial quorum sensing was performed.  Antibiotic resistance testing and host interactions were performed in Staphylococcus-Candida interaction models.  New in vitro models for Candida biofilm development were explored.  A study on failed bonded interfaces submitted to microcosm biofilm caries development was carried out.  Candida albicans metabolism and biofilm heterogeneity were studied by transcriptome mapping.

Clinical studies  The early detection of periapical lesions with color power Doppler was investigated.  Methods of teaching undergraduate students to perform root canal treatment as well as virtual learning environments and its effects on the performance and satisfaction of dental students were studied.

18 Academic Centre for Dentistry Amsterdam

 3-years results showed that the survival rate of the approximal ART restorations is positively influenced by the bilayer technique, and the application of nanofilled coating increases the longevity of the conventional approximal ART restorations.  A study aiming to investigate the influence of parental presence during dental treatment on children's behaviour and perception was carried out. The results showed that the only significant finding lay in the antithesis of how children perceived their last treatment session and how the dentist rated children's behaviour regarding parental presence. Parents' scores of their child's behaviour were unrelated to parental presence.  A multicenter, cross-sectional study was carried out to evaluate the associated factors for developing early childhood caries (ECC) and Severe-ECC (S-ECC) in a group of children aged 24-71 months in Turkey. The results showed a significant difference between the children with caries and caries-free associated with the brushing initiation age started before or after 18 months.  The composition of immune infiltrate in head and neck squamous cell carcinoma is related to tumor outcome.  The presence of viral antigens in HPV-related oropharyngeal tumors might serve as targets for immunotherapy.  Mucoepidermoid carcinoma of the salivary gland has aberrant expression of mucins and carbohydrates  Since 2015 the ORA-STEM/H-OME study is running. The goal is to determine the relationship between several oral complications (like oral mucositis and oral graft-versus-host disease), oral health (caries and periodontitis) and biological determinants like the oral microbiome and proteome in stem cell transplant patients.  We found that sialendoscopy of the major salivary glands improved both the objective (salivary flow rate) and subjective oral dryness in patients with Sjögrens syndrome.  We performed an inventory of the oro-dental manifestations of Crohn’s disease.  We have shown that physical exercise increases salivary viscosity caused by an increase in MUC5B secretion in saliva.  We have shown that salivary agglutinin is the most important complement-stimulating component of saliva.  Several papers based on clinical trials and systematic reviews were published on the topic of prevention and treatment of periodontal diseases and periimplantitis. Such as the added effect of a chemotherapeutic cooling solution in an ultrasonic device or the added effect of lasers and the effect of systemic antibiotics and local disinfection, all adjunctive to scaling and root planning (SCRP). The outcome of SCRP is better explained by the pre-operative periodontal microbiome than the prescription of systemic antibiotics. The efficacy of powered tooth brushing following a single brushing exercise, the efficacy of brushing with and without a dentifrice, CHX mouth rinses and SLS containing dentifrices, the incidence of complications associated with lip and/or tongue piercings and the effect of water on morning bad breath. A clinical study was prepared and performed comparing interdental brushes and the waterflosser on gingival bleeding and gingival abrasions.  Several projects were related to the link between periodontitis and systemic diseases, (cardiovascular diseases and diabetes). Using the ACTA Axium database a study was published that reported on the association between periodontitis and cardiovascular diseases in the Netherlands. The difficulty to interpret the association of periodontitis with various co-morbidities has been discussed in a Letter. Arterial stiffness was found to be associated with periodontitis. We proposed plausible mechanisms how to explain the associations of periodontitis with various diseases.  The research in the department of periodontology also focused on peripheral and oral polymorphonuclear leukocytes (oPMN) and various salivary peptides in maintaining oral health. We reviewed their role and used oral rinses to study numbers and function of oPMN in young adults, edentulous dental patients and periodontitis patients. The results show that oPMN are end stage cells, but yet very capable to phagocytize and digest oral bacteria, and to produce reactive oxygen species, proving their role in the maintenance of oral health.  We studied the microbiomes associated with equine periodontitis and equine oral health.  We showed that microbial profiles at baseline and not the use of antibiotics determine the clinical outcome of the treatment of chronic periodontitis.  A study of the variation in the salivary peptide profiles of young healthy adults was performed.  A cohort study on the dynamics of red fluorescent dental plaque during experimental gingivitis revealed three subpopulations in young healthy adults.

19 Annual Research Report 2016

 The effect of parental presence on the child's perception and co-operation during dental treatment was studied.  A cross-sectional study on the comparison of red autofluorescing plaque and disclosed plaque was performed.

Academic personnel in 2016 Research staff ACTA – OII Oral Infections and Inflammation (in full time equivalents) Position Name 2016 Funding Bloemena, prof.dr. E. 0,20 1 Bruers, prof.dr. J.J.M. 0,40 3 Cate, prof.dr. J.M. ten pm guest Crielaard, prof.dr. W. 0,45 1 Crielaard, prof.dr. W. 0,15 3 Eijkman, prof. dr. M.A.J. pm guest Forouzanfar, prof.dr. T. 0,05 1 Heijden, prof.dr.G. J.M.G. van der 0,50 1 Heijden, prof.dr.G. J.M.G. van der 0,30 3 Jongh, prof.dr. A. de 0,30 1 Keijser, prof.dr.ir. B.J.F. 0,20 3 Lange prof.dr. J. de 0,10 1 Full professors Loos, prof.dr. B.G. 0,40 1 Loveren, prof.dr. C. van 0,40 1 Loveren, prof.dr. C. van 0,10 3 Rozema, prof.dr. F.R. 0,30 3 Schulten, prof.dr. E.A.J.M. 0,10 1 Smeele, prof.dr. L.E. 0,10 3 Veerman, prof.dr. E.C.I. 0,75 1 Velden, prof.dr. U. van der pm guest Verrips, prof.dr. G.H.W. 0,20 3 Weijden, prof.dr. G.A. van der 0,45 1 Weijden, prof.dr. G.A. van der 0,05 3 Wesselink, prof.dr. P.R. pm guest Bikker, dr. F.J. 0,65 1 Bikker, dr. F.J. 0,05 3 Gorter dr. R.C. 0,20 1 Krom, dr. B.P. 0,75 1 Krom, dr. B.P. 0,05 3 Laine, dr. M.L. 0,35 1 Soet, dr. J.J. de 0,35 1 Senior lecturers Shemesh, dr. H. 0,30 1 Steenbergen, dr. T.J.M. van 0,05 1 Strijp, dr. A.J.P. van 0,20 1 Veen, dr.ir. M.H. van der 0,50 1 Wijk, dr. A.J. van 0,50 1 Zaura, dr. E. 0,70 1 Zaura, dr. E. 0,10 3 Aartman, dr. I.H.A. 0,30 1 Other lecturers and tenured Bizzarro, dr. S. 0,40 1 research staff Bolscher, dr. J.G.M. 0,60 1 Bolscher, dr. J.G.M. 0,10 3

20 Academic Centre for Dentistry Amsterdam

Position Name 2016 funding Bonifacio, dr. C.C. 0,20 1 Brand, dr. H.S. 0,15 1 Brand, dr. H.S. 0,20 3 Brandt, dr. B.W. 0,50 1 Brandt, dr. B.W. 0,30 3 Dekker, dr. J., den 0,10 1 Deng, dr. D.M. 0,75 1 Deng, dr. D.M. 0,05 3 Diermen, dr. D.E. van 0,10 1 Other lecturers and tenured Karagozoglu, drs. K.H. 0,10 1 research staff Lagerweij, dr. M.D. 0,20 1 Ligtenberg, dr. A.J.M. 0,55 1 Lindeboom, dr. J.A.H. 0,10 1 Nicu, dr. E.A. 0,70 1 Özok, dr. A.R. 0,40 1 Rosema, dr. N.A.M. 0,20 1 Slot, dr. D.E. 0,55 1 Slot, dr. D.E. 0,05 3 Vries, dr.ir. T.J. de 0,80 1 Total tenured staff 18,35 Anssari Moin, drs. D. 0,15 3 Baaij, drs. A. 0,40 1 Bots, dr. C.P. pm guest Boutsioukis, dr. C. 0,05 1 Cai, dds. Y. 0,75 3 Duijster, dr. D. 0,90 3 Gambon, dr. D.L. pm guest Han, dds. Q. 0,70 3 Hesse, dr. D. 0,10 1 Jager, dr. D.H.J. 0,10 3 Laheij, dr. A.M.G.A. 0,10 1 Laheij, dr. A.M.G.A. 0,60 3 Non tenured staff Liu, dds. H. 0,45 3 Maskrey, MD. N. pm guest Milstein, dr. D.M.J. 0,20 1 Milstein, dr. D.M.J. 0,20 2 Moinzadeh, dr. A.T. 0,10 1 Nes, MSc. K.A. van 0,20 1 Özen, dr. B. 0,20 1 Papagianni, C. 0,05 1 Raber-Durlacher, dr. J.E. 0,40 1 Raber-Durlacher, dr. J.E. 0,10 3 Visscher, dr. J.G.A.M. de 0,10 1 Yang, dds. Y. 0,30 3 Akveld, MSc. N.A.E. pm guest Al Ansari, MSc. S. pm guest Al Hothali, dds. M.M. pm guest PhD students Al Jamaei (Sahar), dds. A.A. 0,50 3 Baâdoudi, MSc. F. 0,75 3 Böhmer, MSc. K.L. ten 0,05 3 Boink, MSc. M.A. pm --

21 Annual Research Report 2016

Position Name 2016 funding Bots- van 't Spijker, drs. P.C. pm guest Broers, drs. D.L.M. pm guest Castro Morais Machado, G. de pm guest Dekker, drs. H. -- pm Delatola, dds. C. 0,20 1 Dijk, MSc. I.A., van -- pm Dijk, drs. S., van 0,20 1 Donders, drs. H.C.M. pm guest Elkerbout, MSc. T.A. pm guest Esposito, dds. S.A. pm guest Everaars, MSc. B. pm guest Geurs, MSc. N.C. pm guest Gunput, MSc. S.T.G. -- pm Hansenova Manaskova, MSc. S. -- pm Haverman, MSc. T.M. 0,25 1 Helmers, drs. R. pm guest Hendra, dds. F.N. 0,25 3 Hertog, drs. D. pm guest Ho, MSc. J.P.T.F. pm guest Houtem, dr. C.M.H.H. van -- pm Hummel, drs. G.I. pm guest Imangaliyev MSc. S. 0,55 3 Janus, ir. M.M. 0,40 3 Jong, MSc. B.G. de 0,65 1 Jong-Lenters, drs. M. de pm guest PhD students Kaper, N. pm guest Koopman, drs. J.E. -- pm Koppelmans, MSc. R.G.A. 0,05 3 Kraaij, MSc. S. pm guest Liao, dds. Y. 0,75 3 Louropoulou, dds. A. pm guest Matse, drs. J.H. -- pm May, MSc. A. 0,40 1 Melo Avila, dds. W. de pm guest Mevissen-Renckens, drs. E.H.M. pm guest Moghimi, drs. M. pm guest Moonen, MSc. C.G.J. 0,70 1 Neelakantan, dds. P. pm guest Papantonopoulos, dds. G.H. pm guest Persoon, MSc. I.F. 0,40 1 Prodan, MSc. A. 0,60 3 Rademacher, MSc. W.M.H. 0,25 1 Raghav, dds. K. pm guest Rijkschroeff, MSc. P. 0,50 1 Roos, drs. C.J.A.M. de pm guest Roseboom, drs. H.J. 0,40 1 Sälzer, dr. S.A. pm guest Scheerman, MSc. J.F.M. 0,15 1 Schreuder, drs. W.H. 0,20 3 Shang, MSc. L. 0,40 3 Sijbrandij, MSc. T. -- pm

22 Academic Centre for Dentistry Amsterdam

Position Name 2016 funding Sluijs, MSc. E. van der pm guest Steegman, drs. J. pm guest Steenen, drs. S.A. pm guest Su, dds. N. pm guest Sun, dds. W. pm guest Tan, drs. C.W.X. pm guest Teeuw, MSc. W.J. 0,40 1 Tuk, drs. J.C. 0,20 1 Veerbeek, drs. H.J. pm guest Verhulst, MSc. J.M.L. 0,75 3 Verstraaten, mw. S. pm guest Vogels, drs. M.P.J.M. pm guest PhD students Volgenant, dr. C.M.C. 0,30 2 Voskuilen, MSc. L. 0,75 1 Vliet, drs. N.I. van pm guest Vries, MSc. M.W. de 0,05 1 Waal, drs. S.V. van der 0,35 1 Weinberg, MSc. F.M. 0,25 1 Widyahening, I. pm guest Wouden, drs. P. van der 0,60 1 Zande, MSC. M.M. van der 0,30 1 Zecha, drs. J.A.E.M. 0,40 1 Zemouri, MSc. C. 0,45 1 Zhao, dds. S. 0,25 3 Ziukaite, MSc. L. 0,15 3 Total non tenured staff 19,20 total 1st funding 24,85 1 total 2nd funding 0,50 2 total 3rd funding 12,20 3 Total research staff 37,55

Output

Dissertations De Jong-Lenters, M. (2016, September 14). Just add positivity? Dental caries, obesity and problem behaviour in children: the role of parents and family relations. Prom./coprom.: prof.dr. C. van Loveren, prof.dr. G.H.W. Verrips & dr. A.A. Schuller. Universiteit van Amsterdam. Hansenova Manaskova, S. (2016, November 11). Exploring Staphylococcus Aureus sortase: A for potential anti- infective applications. Prom./coprom.: prof.dr. E.C.I. Veerman, dr. W.J.B. van Wamel & dr. F.J. Bikker. Vrije Universiteit Amsterdam. Imangaliyev, S.K. (2016, October14). Multi-view learning and deep learning for heterogeneous biological data to maintain oral health. Prom./coprom.: prof.dr. W. Crielaard, prof.dr. B.J.F. Keijser & dr. E. Levin. Universiteit van Amsterdam. Koopman, J.E. (2016, September 9). Ecological dynamics of oral microbial communities. Prom./coprom.: prof.dr. W. Crielaard, prof.dr. B.J.F. Keijser & dr. E. Zaura. Universiteit van Amsterdam. Kraaijenga, S.A.C. (2016, July 8). Long-term oropharyngeal and laryngeal function in patients with advanced head and neck cancer. Prom./coprom.: prof.dr. M.W.M. van den Brekel & prof. dr. F.J.M. Hilgers. Universiteit van Amsterdam. Moinzadeh, A.T. (2016, May 11). Contemporary root canal filling strategies. Prom./coprom.:. prof.dr. P.R. Wesselink, dr. H. Shemesh & dr. P. Zaslansky. Universiteit van Amsterdam.

23 Annual Research Report 2016

Neelakantan, P. (2016, June15). Interactions between root canal irrigants, sealers and dentin. Prom./coprom.: prof.dr. P.R. Wesselink & dr. H. Shemesh. Universiteit van Amsterdam. Papantonopoulos, G. (2016, December 16). On the use of complexity methods in Personalized Periodontology and Implant Dentistry. Prom./coprom.: prof.dr. B.G. Loos & prof.dr. A. Bountis. Universiteit van Amsterdam. Persoon, I.F. (2016, November 11). Insights into the bacterial and fungal ecology of endodontic infections. Prom./coprom.: prof.dr. W. Crielaard & dr. A.R. Özok. Universiteit van Amsterdam. Sälzer, S.A. (2016, December 2). Prevention of gingivitis: Oral hygiene and dentifrices. Prom./coprom.: prof.dr. G.A. van der Weijden, prof.dr. C.E. Dörfer & dr. D.E. Slot. Universiteit van Amsterdam. Van Houtem, C.M.H.H. (2016, November 11). Anxiety, fainting and gagging in dentistry: Separate or overlapping constructs? Prom./coprom.: prof.dr. A. de Jongh & dr. A.J. van Wijk. Universiteit van Amsterdam. Volgenant, C.M.C. (2016, September 30). Red fluorescent dental plaque: An indicator of oral disease? Prom./coprom.: prof.dr. J.M. ten Cate, dr.ir. M.H. van der Veen & dr. J.J. de Soet. Universiteit van Amsterdam.

Scientific publications (refereed) Amara, N., Gregor, R., Rayo, J., Dandela, R., Daniel, E., Liubin, N., Willems, H.M.E., Ben-Zvi, A., Krom, B.P. & Meijler, M.M. (2016). Fine-tuning covalent inhibition of bacterial quorum sensing. ChemBioChem, vol 17, no. 9, pp. 825-835. DOI: 10.1002/cbic.201 500676 Baâdoudi, F., Maskrey, N., Listl, S., van der Heijden, G.J.M.G. & Duijster, D. (2016). Improving oral healthcare: Towards measurement? British Dental Journal, vol 221, no. 9, pp. 547-548. DOI: 10.1038/sj.bdj.2016.813 Barasch, A., Raber-Durlacher, J., Epstein, J.B. & Carroll, . (2016). Effects of pre-radiation exposure to LLLT of normal and malignant cells. Supportive Care in Cancer, vol 24, no. 6, pp. 2497-2501. DOI: 10.1007/s00520- 015-3051-8 Beth, S.A., Jansen, M.A.E., Elfrink, M.E.C., Kiefte-de Jong, J.C., Wolvius, E.B., Jaddoe, V.W.V., Zelm, M.C.V. & Moll, H.A. (2016). Generation R birth cohort study shows that specific enamel defects were not associated with elevated serum transglutaminase type 2 antibodies. Acta Paediatrica, vol 105, no. 10, pp. e485-e491. DOI: 10.1111/apa.13533 Beukers, N.G.F.M., van der Heijden, G.J.M.G., van Wijk, AJ & Loos, B.G. (2016). Periodontitis is an independent risk indicator for atherosclerotic cardiovascular diseases among 60 174 participants in a large dental school in the Netherlands Journal of Epidemiology and Community Health, vol 71, no. 1, pp. 37-42. DOI: 10.1136/jech-2015-206745 Bizzarro, S., Laine, M.L., Buijs, M.J., Brandt, B.W., Crielaard, W., Loos, B.G. & Zaura, E. (2016). Microbial profiles at baseline and not the use of antibiotics determine the clinical outcome of the treatment of chronic periodontitis. Scientific Reports, vol 6, 20205. DOI: 10.1038/srep20205 Bizzarro, S., van der Velden, U & Loos, B.G. (2016). Local disinfection with sodium hypochlorite as adjunct to basic periodontal therapy: a randomized controlled trial. Journal of Clinical Periodontology, vol 43, no. 9, pp. 778-788. DOI: 10.1111/jcpe.12578 Boink, M.A., Roffel, S., Nazmi, K., van Montfrans, C., Bolscher, J.G.M., Gefen, A., Veerman, E.C.I. & Gibbs, S. (2016). The influence of chronic wound extracts on inflammatory cytokine and histatin.. stability PLoS One, vol 11, no. 3, 0152613. DOI: 10.1371/journal.pone.0152613 Boink, M.A., van den Broek, L.J., Roffel, S., Nazmi, K., Bolscher, J.G.M., Gefen, A., Veerman, E.C.I. & Gibbs, S. (2016). Different wound healing properties of dermis, adipose, and gingiva mesenchymal stromal cells Wound Repair and Regeneration, vol 24, no. 1, pp. 100-109. DOI: 10.1111/wrr.12380 Boka, V., Arapostathis, K., Karagiannis, V., Kotsanos, N., van Loveren, C. & Veerkamp, J. (2016). The effect of parental presence on the childs perception and co-operation during dental treatment. European Archives of Paediatric Dentistry, vol 17, no. 5, pp. 381-386. DOI: 10.1007/s40368-016-0241-0 Boka, V., Lefkelidou, A. & Athanasiadou, E. (2016). Dental treatment of a child with congenital central hypoventilation syndrome. European Archives of Paediatric Dentistry, vol 17, no. 3, pp. 211-214. DOI: 10.1007/s40368-015-0213-9 Boks, M.A., Gunput, S.T.G., Kosten, I., Gibbs, S., van Vliet, S.J., Ligtenberg, A.J.M. & van Kooyk, Y. (2016). The human glycoprotein salivary agglutinin inhibits the interaction of dc-sign and langerin with oral microorganisms. Journal of Innate Immunity, vol 8, no. 4, pp. 350-361. DOI: 10.1159/000443016

24 Academic Centre for Dentistry Amsterdam

Bosch, A.A.T.M., Levin, E. van Houten, M.A., Hasrat, R., Kalkman, G., Biesbroek, G., de Steenhuijsen Piters, W.A.A., de Groot, P.K.C.M., Pernet, P., Keijser, B.J.F., Sanders, E.A.M. & Bogaert, D. (2016). Development of upper respiratory tract microbiota in infancy is affected by mode of delivery. EBIOMEDICINE, vol 9, pp. 336- 345. DOI: 10.1016/j.ebiom.2016.05.031 Bots-van ’t Spijker, P.C., Bruers, J.J.M., Bots, C.P., Vanobbergen, J.N.O., de Visschere, L.M.J., de Baat, C. & Schols, J.M.G.A. (2016). Opinions of dentists on the barriers in providing oral health care to community- dwelling frail older people: a questionnaire survey. Gerodontology, vol 33, no. 2, pp. 268-274. DOI: 10.1111/ger.12155 Boutsioukis, C. & Tzimpoulas, N. (2016). Uncontrolled removal of dentin during in vitro ultrasonic irrigant activation. The Journal of Endodontics, vol 42, no. 2, pp. 289-293. DOI: 10.1016/j.joen.2015.09.017 Bruers, J.J.M., van Dam, B.A.F.M., Gorter, R.C. & Eijkman, M.A.J. (2016). The impact of a formal complaint on Dutch dentists professional practice: a survey study. BMC Oral Health, vol 16, 104. DOI: 10.1186/s12903- 016-0295-8 Cao, Y., Jansen, I.D.C., Sprangers, S., Stap, J., Leenen, P.J.M., Everts, V. & de Vries, T.J. (2016). IL-1β differently stimulates proliferation and multinucleation of distinct mouse bone marrow osteoclast precursor subsets. Journal of Leukocyte Biology, vol 100, no. 3, pp. 513-523. DOI: 10.1189/jlb.1A1215-543R De Almeida, J., Hoogenkamp, M., Felippe, W.T., Crielaard, W. & van der Waal, S.V. (2016). Effectiveness of EDTA and modified salt solution to detach and kill cells from Enterococcus faecalis biofilm. The Journal of Endodontics, vol 42, no. 2, pp. 320-323. DOI: 10.1016/j.joen.2015.11.017 De Bont, P.A.J.M., van den Berg, D.P.G., van der Vleugel, B.M., de Roos, C., de Jongh, A., van der Gaag, M. & van Minnen, A.M. (2016). Prolonged exposure and EMDR for PTSD v. a PTSD waiting-list condition: effects on symptoms of psychosis, depression and social functioning in patients with chronic psychotic disorders. Psychological Medicine, vol 46, no. 11, pp. 2411-2421. DOI: 10.1017/S0033291716001094 De Jongh, A., Resick, P.A., Zoelner, L.A., van Minnen, A., Lee, C.W., Monson, C.M., Foa, E.B., Wheeler, K., ten Broeke, E., Feeny, N., Rauch, S.A.M., Chard, K.M., Mueser, K.T., Sloan, D.M., van der Gaag, M., Rothbaum, B.O., Neuner, F., de Roos, C., Hehenkamp, L.M.J., Rosner, R. & Bicanic, I.A.E. (2016). Critical analysis of the current treatment guidelines for complex ptsd in adults. Depression and Anxiety, vol 33, no. 5, pp. 359-369. DOI: 10.1002/da.22469 De Jongh, A., van Wijk, A.J., Horstman, M. & de Baat, C. (2016). Self-perceived halitosis influences social interactions. BMC Oral Health, vol 16, 31. DOI: 10.1186/s12903-016-0189-9 De Vries, T.J. (2016). Antisense sense in osteoclasts. The American Journal of Pathology, vol 186, no. 9, pp. 2248-2250. DOI: 10.1016/j.ajpath.2016.06.004 De Vries, T.J., Yousovich, J., Schoenmaker, T., Scheres, N. & Everts, V. (2016). Tumor necrosis factor- α infliximab inhibits osteoclast formation of peripheral blood mononuclear cells but does not affect periodontal ligament fibroblast-mediated osteoclast formation. Journal of Periodontal Research, vol 51, no. 2, pp. 186-195. DOI: 10.1111/jre.12297 Elfrink, M.E.C., Kalin, K., van Ruijven, L.J., ten Cate, J.M. & Veerkamp, J.S.J. (2016). MicroCT study on the enamel mineral density of primary molars. European Journal of Paediatric Dentistry, vol 17, no. 1, 26949242, pp. 60-64. Elkerbout, T.A., Slot, D.E., Bakker, E.W.P. & van der Weijden, G.A. (2016). Chlorhexidine mouthwash and sodium lauryl sulphate dentifrice: do they mix effectively or interfere? International Journal of Dental Hygiene, vol 14, no. 1, pp. 42-52. DOI: 10.1111/idh.12125 Fles, R., Indrasari, S.R., Herdini, C., Martini, S., Isfandiari, A., Romdhoni, A.C., Adham, M., Mayangsari, I.D., van Werkhoven, E., Wildeman, M.A., Hariwiyanto, B., Hermani, B., Kentjono, W.A., Haryana, S.M., Schmidt, M.K. & Tan, I.B. (2016). Effectiveness of a multicentre nasopharyngeal carcinoma awareness programme in Indonesia BMJ Open, vol 6, no. 3, pp. e008571. DOI: 10.1136/bmjopen-2015-008571 Gunput, S.T.G., Wouters, D., Nazmi, K., Cukkemane, N., Brouwer, M., Veerman, E.C.I. & Ligtenberg, A.J.M. (2016). Salivary agglutinin is the major component in human saliva that modulates the lectin pathway of the complement system. Innate Immunity, vol 22, no. 4, pp. 257-265. DOI: 10.1177/1753425916642614 Han, A., Li, X., Huang, B., Tsoi, JK-H., Matinlinna, J.P., Chen, Z. & Deng, D.M. (2016). The effect of titanium implant surface modification on the dynamic process of initial microbial adhesion and biofilm formation. International Journal of Adhesion and Adhesives, vol 69, pp. 125-132. DOI: 10.1016/j.ijadhadh.2016.03.018 Hansenova Manaskova, S., Bikker, F.J., Nazmi, K., van Zuidam, R., Slotman, J.A., van Capellen, W.A., Houtsmuller, A.B., Veerman, E.C.I. & Kaman, W.E. (2016). Incorporation of a valine−leucine−lysine- containing substrate in the bacterial cell wall. Bioconjugate Chemistry, vol 27, no. 10, pp. 2418-2423. DOI: 10.1021/acs.bioconjchem.6b00381

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Hansenová Maňásková, S., Nazmi, K., van t Hof, W., van Belkum, A., Martin, N.I., Bikker, F.J., van Wamel, W.J.B. & Veerman, E.C.I. (2016). Staphylococcus aureus sortase a-mediated incorporation of peptides: Effect of peptide modification on incorporation. PLoS One, vol 11, no. 1, e01474. DOI: 10.1371/journal.pone.0147401 Hansenová Maňásková, S, van Belkum, A., Endtz, H.P., Bikker, F.J., Veerman, E.C.I. & van Wamel, W.J.B. (2016). Comparison of non-magnetic and magnetic beads in bead-based assays. Journal of Immunological Methods, vol 436, pp. 29-33. DOI: 10.1016/j.jim.2016.06.003 Heidsieck, D.S.P., de Ruiter, M.H.T. & de Lange, J. (2016). Management of obstructive sleep apnea in edentulous patients: an overview of the literature. Sleep and Breathing, vol 20, no. 1, pp. 395-404. DOI: 10.1007/s11325-015-1285-9 Hennequin-Hoenderdos, N.L., Slot, D.E. & van der Weijden, G.A. (2016). The incidence of complications associated with lip and/or tongue piercings: a systematic review. International Journal of Dental Hygiene, vol 14, no. 1, pp. 62-73. DOI: 10.1111/idh.12118 Hesse, D., Bonifácio, C.C., Bönecker, M.A.B. Guglielmi, C.D., da Franca, C., van Amerongen, W.E., Colares, V. & Raggio, D.P. (2016). Survival rate of Atraumatic Restorative Treatment (ART) restorations using a glass ionomer bilayer technique with a nanofilled coating: a bi-center randomized clinical trial. Pediatric Dentistry, vol 38, no. 1, pp. 18-24. Hesse, D., Bonifácio, C.C., de Almeida Brandão Guglielmi, C., Bönecker, M., van Amerongen, W.E. & Raggio, D.P. (2016). Bilayer technique and nano-filled coating increase success of approximal ART restorations: a randomized clinical trial. International Journal of Paediatric Dentistry, vol 26, no. 3, pp. 231-239. DOI: 10.1111/ipd.12194 Hesse, D., Pinheiro de Araujo, M., Olegário, I.C., Innes, N,. Raggio, D. P. & Bonifácio, C.C. (2016). Atraumatic Restorative Treatment compared to the Hall Technique for occluso-proximal cavities in primary molars: study protocol for a randomized controlled trial. Trials, vol 17, 169. DOI: 10.1186/s13063-016-1270-z Houcken, W., Teeuw, W.J., Bizzarro, S., Rodriguez, E.A., Mulders, T.A., van den Born, B-JH. & Loos, B.G. (2016). Arterial stiffness in periodontitis patients and controls: A case-control and pilot intervention study. Journal of Human Hypertension, vol 30, no. 1, pp. 24-29. DOI: 10.1038/jhh.2015.41 Huang, L., van Loveren, C., Ling, J., Wei, X., Crielaard, W. & Deng, D.M. (2016). Epithelial cell detachment by Porphyromonas gingivalis biofilm and planktonic cultures. BIOFOULING, vol 32, no. 4, pp. 489-496. DOI: 10.1080/08927014.2016.1148693 Jacobi, I., Navran, A., van der Molen, L., Heemsbergen, W.D., Hilgers, F.J.M. & van den Brekel, M.W.M. (2016). Radiation dose to the tongue and velopharynx predicts acoustic-articulatory changes after chemo-IMRT treatment for advanced head and neck cancer. European Archives of Oto-Rhino-Laryngology, vol 273, no. 2, pp. 487-494. DOI: 10.1007/s00405-015-3526-8 Jacobi, I., Timmermans, A.J., Hilgers, F.J.M. & van den Brekel, M.W.M. (2016). Voice quality and surgical detail in post-laryngectomy tracheoesophageal speakers. European Archives of Oto-Rhino-Laryngology, vol 273, no. 9, pp. 2669-2679. DOI: 10.1007/s00405-015-3777-4 Jager, D.J., Karagozoglu, K.H., Maarse, F., Brand, H.S. & Forouzanfar, T. (2016). Sialendoscopy of salivary glands affected by Sjögren syndrome: a randomized controlled pilot study. Journal of Oral and Maxillofacial Surgery, vol 74, no. 6, pp. 1167-1174. DOI: 10.1016/j.joms.2015.12.019 Janus, M.M., Crielaard, W., Zaura, E., Keijser, B.J., Brandt, B.W. & Krom, B.P. (2016). A novel compound to maintain a healthy oral plaque ecology in vitro. Journal of Oral Microbiology, vol 8, 32513. DOI: 10.3402/jom.v8.32513 Janus, M.M., Willems, H.M.E. & Krom, B.P. (2016). Candida albicans in multispecies oral communities; a keystone commensal? Advances in Experimental Medicine and Biology, vol 931, pp. 13-20. DOI: 10.1007/5584_2016_5 Jepsen, K., Jepsen, S., Laine, M.L., Anssari Moin, D., Pilloni, A., Zeza, B., Sanz, M., Ortiz-Vigon, A., Roos- Jansaker, A.M. & Renvert, S. (2016). Reconstruction of peri-implant osseous defects: a multicenter randomized trial. Journal of Dental Research, vol 95, no. 1, pp. 58-66. DOI: 10.1177/0022034515610056 Kennedy, R., Lappin, D.F., Dixon, P.M., Buijs, M.J., Zaura, E., Crielaard, W., ODonnell, L., Bennett, D., Brandt, B.W. & Riggio, M.P. (2016). The microbiome associated with equine periodontitis and oral health. Veterinary Research, vol 47, 49. DOI: 10.1186/s13567-016-0333-1 Kilian, M., Chapple, I.L.C., Hannig, M., Marsh, P.D., Meuric, V., Pedersen, A.M.L., Tonetti, M.S., Wade, W.G. & Zaura, E. (2016). The oral microbiome - an update for oral healthcare professionals. British Dental Journal, vol 221, no. 10, pp. 657-666. DOI: 10.1038/sj.bdj.2016.865 Koçak, E., Sağlam, M., Kayış, S.A., Dündar, N., Kebapçılar, L., Loos, B.G. & Hakki, S.S. (2016). Nonsurgical periodontal therapy with/without diode laser modulates metabolic control of type 2 diabetics with

26 Academic Centre for Dentistry Amsterdam

periodontitis: a randomized clinical trial. Lasers in Medical Science, vol 31, no. 2, pp. 343-353. DOI: 10.1007/s10103-016-1868-0 Koopman, J.E., Buijs, M.J., Brandt, B.W., Keijser, B.J.F., Crielaard, W. & Zaura, E. (2016). Nitrate and the origin of saliva influence composition and short chain fatty acid production of oral microcosms. Microbial Ecology, vol 72, no. 2, pp. 479-492. DOI: 10.1007/s00248-016-0775-z Kortekaas, M.F., Bartelink, M.L.E.L., van der Heijden, G.J.M.G., Hoes, A.W. & de Wit, N.J. (2016). Development and validation of a new instrument measuring guideline adherence in clinical practice. Family Practice, vol 33, no. 5, cmw063, pp. 562-568. DOI: 10.1093/fampra/cmw063 Kortekaas, MF, Bartelink, MEL, Zuithoff, NPA, van der Heijden GJMG, de Wit, NJ, Hoes, AW. (2016). Does integrated training in evidence-based medicine (EBM) in the general practice (GP) specialty training improve EBM behaviour in daily clinical practice? A cluster randomised controlled trial. BMJ Open;6: e010537. doi:10.1136/ bmjopen-2015-010537 Kraaijenga, S.A.C., Oskam, I.M., van Son, R.J.J.H., Hamming-Vrieze, O., Hilgers, F.J.M., van den Brekel, M.W.M. & van der Molen, L. (2016). Assessment of voice, speech, and related quality of life in advanced head and neck cancer patients 10-years+ after chemoradiotherapy. Oral Oncology, vol 55, pp. 24-30. DOI: 10.1016/j.oraloncology.2016.02.001 Krom, B.P., Levy, N., Meijler, M.M. & Jabra-Rizk, M.A. (2016). Farnesol and Candida albicans: quorum sensing or not quorum sensing? Israel Journal of Chemistry, vol 56, no. 5, pp. 295-301. DOI: 10.1002/ijch.201500025 Kuiper, J.L., Hashemi, S.M.S., Thunnissen, E., Snijders, P.J.F., Grünberg, K., Bloemena, E., Sie, D., Postmus, P.E., Heideman, D.A.M. & Smit, E.F. (2016). Non-classic EGFR mutations in a cohort of Dutch EGFR-mutated NSCLC patients and outcomes following EGFR-TKI treatment. The British Journal of Cancer, vol 115, no. 12, pp. 1504-1512. DOI: 10.1038/bjc.2016.372 Liao, Y., Brandt, B.W., Zhang, M., Li, J., Crielaard, W., van Loveren, C. & Deng, D.M. (2016). A single nucleotide change in the promoter mutp enhances fluoride resistance of Streptococcus mutans. Antimicrobial Agents and Chemotherapy, vol 60, no. 12, pp. 7509-7512. DOI: 10.1128/AAC.01366-16 Ligtenberg, A.J.M., Liem, E., Brand, H.S. & Veerman, E.C.I. (2016). The effect of exercise on salivary viscosity. Diagnostics, vol 6, no. 4, pp. E40. DOI: 10.3390/diagnostics6040040 Limonard, E.J., Schoenmaker, T., de Vries, T.J., Tanck, M., Heijboer, A.C., Endert, E., Fliers, E., Everts, V. & Bisschop, P.H. (2016). Clonidine increases bone resorption in humans. Osteoporosis International, vol 27, no. 3, pp. 1063-1071. DOI: 10.1007/s00198-015-3312-x Lodders, J.N., Schulten, E.A.J.M., de Visscher, J.G.A.M., Forouzanfar, T. & Karagozoglu, K.H. (2016). Complications and risk after mandibular reconstruction with fibular free flaps in patients with oral squamous cell carcinoma: a retrospective cohort study. Journal of Reconstructive Microsurgery, vol 32, no. 6, pp. 455-463. DOI: 10.1055/s-0036-1571794 Logie, R.D.J. & de Jongh, A. (2016). Die Flashforward-Technik: sich der Katastrophe stellen. Journal of EMDR Practice and Research, vol 10, no. 2, pp. 68E-76E (9). Loos, B.G. (2016). Periodontal medicine: work in progress! Journal of Clinical Periodontology, vol 43, no. 6, pp. 470-471. DOI: 10.1111/jcpe.12550 Loos, B.G. (2016). Severe periodontitis may result in higher numbers of oral polymorphonuclear (oPMN) leukocytes in oral rinse samples The Journal of Evidence-Based Dental Practice, vol 16, no. 1, pp. 73-74. May, A., Brandt, B.W., El-Kebir, M., Klau, G.W., Zaura, E., Crielaard, W., Heringa, J. & Abeln, S. (2016). metaModules identifies key functional subnetworks in microbiome-related disease Bioinformatics, vol 32, no. 11, pp. 1678-1685. DOI: 10.1093/bioinformatics/btv526 Mevissen, L., Didden, R., Korzilius, H. & de Jongh, A. (2016). Assessing posttraumatic stress disorder in children with mild to borderline intellectual disabilities. European Journal of Psychotraumatology, vol 7, no. 1, 29786. DOI: 10.3402/ejpt.v7.29786 Milstein, D.M.J., Ince, C., Gisbertz, S.S., Boateng, K.B., Geerts, B.F., Hollmann, M.W., van Berge Henegouwen, M.I. & Veelo, D.P. (2016). Laser speckle contrast imaging identifies ischemic areas on gastric tube reconstructions following esophagectomy. Medicine, vol 95, no. 25, pp. e3875. DOI: 10.1097/MD.0000000000003875 Moinzadeh, A.T., Farack, L., Wilde, F., Shemesh, H. & Zaslansky, P. (2016). Synchrotron-based phase contrast- enhanced micro-computed tomography reveals delaminations and material tearing in water-expandable root fillings ex vivo. The Journal of Endodontics, vol 42, no. 5, pp. 776-781. DOI: 10.1016/j.joen.2016.01.023 Monsuur, H.N., Boink, M.A., Weijers, E.M., Roffel, S., Breetveld, M., Gefen, A., van den Broek, L.J. & Gibbs, S. (2016). Methods to study differences in cell mobility during skin wound healing in vitro. Journal of Biomechanics, vol 49, no. 8, pp. 1381-1387. DOI: 10.1016/j.jbiomech.2016.01.040

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Montagner, A.F., Maske, T.T., Opdam, N.J., de Soet, J.J., Cenci, M.S. & Huysmans, M.C .(2016). Failed bonded interfaces submitted to microcosm biofilm caries development. Journal of Dentistry, vol 52, pp. 63-69. DOI: 10.1016/j.jdent.2016.07.007 Nasr, S., Slot, D.E., Bahaa, S., Dörfer, C.E. & Fawzy El-Sayed, K.M. (2016). Dental implants combined with sinus augmentation: What is the merit of bone grafting? A systematic review. Journal of Cranio-Maxillofacial Surgery, vol 44, no. 10, pp. 1607-1617. DOI: 10.1016/j.jcms.2016.06.022 Neilands, J., Bikker, F.J. & Kinnby, B. (2016). PAI-2/SerpinB2 inhibits proteolytic activity in a P. gingivalis- dominated multispecies bacterial consortium. Archives of Oral Biology, vol 70, pp. 1-8. DOI: 10.1016/j.archoralbio.2016.05.016 Nicu, E.A. & Loos, B.G. (2016). Polymorphonuclear neutrophils in periodontitis and their possible modulation as a therapeutic approach. Periodontology 2000, vol 71, no. 1, pp. 140-163. DOI: 10.1111/prd.12113 Olegário, I.C., Hesse, D., Bönecker, M., Pettorossi Imparato, J.C., Minatel Braga, M., Medeiros Mendes, F. & Prócida Raggio, D. (2016). Effectiveness of conventional treatment using bulk-fill composite resin versus Atraumatic Restorative Treatments in primary and permanent dentition: a pragmatic randomized clinical trial. BMC Oral Health, vol 17, 34. DOI: 10.1186/s12903-016-0260-6 Oomens, M.A.E.M., Lazzari, S., Heymans, M.W. & Forouzanfar, T. (2016). Association between funding, risk of bias, and outcome of randomised controlled trials in oral and maxillofacial surgery. British Journal of Oral & Maxillofacial Surgery, vol 54, no. 1, pp. 46-50. DOI: 10.1016/j.bjoms.2015.10.021 Özen, B., van Strijp, A.J.P., Özer, L., Olmus, H., Genc, A. & Cehreli, S.B. (2016). Evaluation of possible associated factors for early childhood caries and severe early childhood caries: a multicenter cross-sectional survey. Journal of Clinical Pediatric Dentistry, vol 40, no. 2, pp. 118-123. DOI: 10.17796/1053-4628-40.2.118 Pakpour, A.H., Kumar, S., Scheerman, J.F.M., Lin, C.Y., Fridlund, B. & Jansson, H. (2016). Oral health-related quality of life in Iranian patients with spinal cord injury: a case-control study. Injury, vol 47, no. 6, pp. 1345- 1352. DOI: 10.1016/j.injury.2016.03.022 Passchier, E., Stuiver, M.M., van der Molen, L., Kerkhof, S.I.C., van den Brekel, M.W.M. & Hilgers, F.J.M. (2016). Feasibility and impact of a dedicated multidisciplinary rehabilitation program on health-related quality of life in advanced head and neck cancer patients. European Archives of Oto-Rhino-Laryngology, vol 273, no. 6, pp. 1577-1587. DOI: 10.1007/s00405-015-3648-z PradeepKumar, A.R., Shemesh, H., Jothilatha, S., Vijayabharathi, R., Jayalakshmi, S. & Kishen, A. (2016). Diagnosis of vertical root fractures in restored endodontically treated teeth: A time-dependent retrospective cohort study. The Journal of Endodontics, vol 42, no. 8, pp. 1175-1180. DOI: 10.1016/j.joen.2016.04.012 Prodan, A., Brand, H., Imangaliyev, S., Tsivtsivadze, E., van der Weijden, F., de Jong, A., Paauw, A., Crielaard, W., Keijser, B. & Veerman, E. (2016). A study of the variation in the salivary peptide profiles of young healthy adults acquired using MALDI-TOF MS. PLoS One, vol 11, no. 6, e0156707. DOI: 10.1371/journal.pone.0156707 Prodan, A., Imangaliyev, S., Brand, H.S., Rosema, M.N.A., Levin, E., Crielaard, W., Keijser, B.J.F. & Veerman, E.C.I. (2016). Effect of experimental gingivitis induction and erythritol on the salivary metabolome and functional biochemistry of systemically healthy young adults. Metabolomics, vol 12, pp. 147. DOI: 10.1007/s11306-016-1096-4 Puknun, A., Kanthawong, S., Anutrakunchai, C., Nazmi, K., Tigchelaar, W., Hoeben, K.A., Veerman, E.C.I., Bolscher, J.G.M. & Taweechaisupong, S. (2016). Ultrastructural effects and antibiofilm activity of LFchimera against Burkholderia pseudomallei. World Journal Of Microbiology & Biotechnology, vol 32, no. 2, 33. DOI: 10.1007/s11274-015-1988-x Punt, S., Dronkers, E.A.C., Welters, M.J.P., Goedemans, R., Koljenovic, S., Bloemena, E., Snijders, P.J.F., Gorter, A., van der Burg, S.H., Baatenburg de Jong, R.J.B. & Jordanova, E.S. (2016). A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL- 17(+) cell frequency. Cancer Immunology and Immunotherapy, vol 65, no. 4, pp. 393-403. DOI: 10.1007/s00262-016-1805-x Raghav, K., van Wijk, A.J., Abdullah, F., Islam, M.N., Bernatchez, M. & de Jongh, A. (2016). Efficacy of virtual reality exposure therapy for treatment of dental phobia: a randomized control trial. BMC Oral Health, vol 16, 25. DOI: 10.1186/s12903-016-0186-z Rajendran, R., May, A., Sherry, L., Kean, R., Williams, C., Jones, B.L., Burgess, K.V., Heringa, J., Abeln, S., Brandt, B.W., Munro, C.A. & Ramage, G. (2016). Integrating Candida albicans metabolism with biofilm heterogeneity by transcriptome mapping. Scientific Reports, vol 6, 35436. DOI: 10.1038/srep35436

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Ravesloot, M.J.L., Frank, M.H., van Maanen, J.P., Verhagen, E.A., de Lange, J. & de Vries, N. (2016). Positional OSA part 2: retrospective cohort analysis with a new classification system (APOC). Sleep and Breathing, vol 20, no. 2, pp. 881-888. DOI: 10.1007/s11325-015-1206-y Retsas, A. Koursoumis, A., Tzimpoulas, N. & Boutsioukis, C. (2016). Uncontrolled removal of dentin during in vitro ultrasonic irrigant activation in curved root canals. The Journal of Endodontics, vol 42, no. 10, pp. 1545-1549. DOI: 10.1016/j.joen.2016.07.006 Rijkschroeff, P., Jansen, I.D.C., van der Weijden, F.A., Keijser, B.J.F., Loos, B.G. & Nicu, E.A. (2016). Oral polymorphonuclear neutrophil characteristics in relation to oral health: a cross-sectional, observational clinical study. International Journal of Oral Science, vol 8, no. 3, pp. 191-198. DOI: 10.1038/ijos.2016.23 Rosema, N.A.M., Slot, D.E., van Palenstein Helderman, W.H., Wiggelinkhuizen, L. & van der Weijden, G.A. (2016). The efficacy of powered toothbrushes following a brushing exercise: a systematic review. International Journal of Dental Hygiene, vol 14, no. 1, pp. 29-41. DOI: 10.1111/idh.12115 Ruslin, M., Boffano, P., ten Brincke, Y.J.D., Forouzanfar, T. & Brand, H.S. (2016). Sport-related maxillofacial fractures. The Journal of Craniofacial Surgery, vol 27, no. 1, pp. e91-e94. DOI: 10.1097/SCS.0000000000002242 Sälzer, S, Graetz, C, Plaumann, A, Heinevetter, N, Grender, J, Klukowska, M, Schneider, CA, Springer, C, van der Weijden, F.A. & Dörfer, CE (2016). Effect of a multidirectional power toothbrush and a manual toothbrush in individuals susceptible to gingival recession: A 12-month randomized controlled clinical study Journal of Periodontology, vol 87, no. 5, pp. 548-556. DOI: 10.1902/jop.2016.150472 Sälzer, S., Rosema, N.A.M., Martin, E.C.J., Slot, D.E., Timmer, C.J., Dörfer, C.E. .& van der Weijden, G.A. (2016). The effectiveness of dentifrices without and with sodium lauryl sulfate on plaque, gingivitis and gingival abrasion: a randomized clinical trial. Clinical Oral Investigations, vol 20, no. 3, pp. 443-450. DOI: 10.1007/s00784-015-1535-z Sauro, S., Lin, C.Y., Bikker, F.J., Cama, G., Dubruel, P., Soria, J.M., DOnofrio, A. & Gillam, D. (2016). Di-calcium phosphate and phytosphingosine as an innovative acid-resistant treatment to occlude dentine tubules. Caries Research, vol 50, no. 3, pp. 303. DOI: 10.1159/000445444 Scheerman, J.F.M., van Loveren, C., van Meijel, B., Dusseldorp, E., Wartewig, E., Verrips, G.H.W., Ket, J.C.F. & van Empelen, P. (2016). Psychosocial correlates of oral hygiene behaviour in people aged 9 to 19: a systematic review with meta-analysis. Community Dentistry and Oral Epidemiology, vol 44, no. 4, pp. 331- 341. DOI: 10.1111/cdoe.12224 Schouten, C.S., Hakim, S., Boellaard, R., Bloemena, E., Doornaert, P.A,. Witte, B.I., Braakhuis, B.J.M., Brakenhoff, R.H., Leemans, C.R., Hoekstra, O.S. & de Bree, R. (2016). Interaction of quantitative 18F-FDG- PET-CT imaging parameters and human papillomavirus status in oropharyngeal squamous cell carcinoma. Head & Neck, vol 38, no. 4, pp. 529-535. DOI: 10.1002/hed.23920 Schwarz, F., Becker, K., Bastendorf, K.D., Cardaropoli, D., Chatfield, C., Dunn, I., Fletcher, P., Einwag, J., Louropoulou, A., Mombelli, A., Ower, P., Pavlovic, P., Sahrmann, P., Salvi, G.E., Schmage, P., Takeuchi, Y. van der Weijden, F. & Renvert, S. (2016). Recommendations on the clinical application of air polishing for the management of peri-implant mucositis and peri-implantitis. Quintessence International, vol 47, no. 4, pp. 293-296. DOI: 10.3290/j.qi.a35132 Sonis, S.T., Hashemi, S., Epstein, J.B., Nair, R.G. & Raber-Durlacher, J.E. (2016). Could the biological robustness of low level laser therapy (Photobiomodulation) impact its use in the management of mucositis in head and neck cancer patients. Oral Oncology, vol 54, pp. 7-14. DOI: 10.1016/j.oraloncology.2016.01.005 Sprangers, S., de Vries, T.J. & Everts, V. (2016). Monocyte heterogeneity: consequences for monocyte-derived immune cells. Journal of Immunology Research, vol (2016). 1475435. DOI: 10.1155/2016/1475435 Sprangers, S., Schoenmaker, T., Cao, Y., Everts, V. & de Vries, T.J. (2016). Different blood-borne human osteoclast precursors respond in distinct ways to IL-17A Journal of Cellular Physiology, vol 231, no. 6, pp. 1249-1260. DOI: 10.1002/jcp.25220 Steenen, S.A. & Becking, A.G. (2016). Bad splits in bilateral sagittal split osteotomy: systematic review of fracture patterns. International Journal of Oral and Maxillofacial Surgery, vol 45, no. 7, pp. 887-897. DOI: 10.1016/j.ijom.2016.02.001 Steenen, S.A., van Wijk, A.J. & Becking, A.G. (2016). Bad splits in bilateral sagittal split osteotomy: systematic review and meta-analysis of reported risk factors. International Journal of Oral and Maxillofacial Surgery, vol 45, no. 8, pp. 971-979. DOI: 10.1016/j.ijom.2016.02.011 Steenen, S.A., van Wijk, A.., van der Heijden, G.J.M.G., van Westrhenen, R., de Lange, J. & de Jongh, A. (2016). Propranolol for the treatment of anxiety disorders: systematic review and meta-analysis. Journal of Psychopharmacology, vol 30, no. 2, pp. 128-139. DOI: 10.1177/0269881115612236

29 Annual Research Report 2016

Stoker, S.D., Fles, R., Herdini, C., Rijntjes, F.J.F., Tjokronagoro, M., Dwidanarti, S.R., Sikorska, K., Leemans, C.R., Schmidt, M.K., Al-Mamgani, A., Wildeman, A., Haryana, S.M., Indrasari, S.R. & Tan, I.B. (2016). The impact of the overall radiotherapy time on clinical outcome of patients with nasopharyngeal carcinoma: a retrospective study. PLoS One, vol 11, no. 3, pp. 0151899. DOI: 10.1371/journal.pone.0151899 Stoker, S.D., Wildeman, M.A., Novalic, Z., Fles, R., van der Noort, V., de Bree, R., Braunius, W.W., van den Broek, G.B., Kreike, B., Kross, K.W., Juwana, H., Ramayanti, O., Verkuijlen, S.A.W.M., de Boer, J.P., Greijer, A.E., Middeldorp, J.M. & Tan, I.B. (2016). Can Epstein-Barr virus DNA load in nasopharyngeal brushings or whole blood predict recurrent nasopharyngeal carcinoma in a non-endemic region?: A prospective nationwide study of the Dutch Head and Neck Oncology Cooperative Group. European Archives of Oto- Rhino-Laryngology, vol 273, no. 6, pp. 1557-1567. DOI: 10.1007/s00405-015-3620-y Sungur, D.D., Moinzadeh, A.T., Wesselink, P.R., Tarhan, S.C. & Özok, A.R. (2016). Sealing efficacy of a single- cone root filling after post space preparation. Clinical Oral Investigations, vol 20, no. 5, pp. 1071-1077. DOI: 10.1007/s00784-015-1593-2 Tabeian, H., Bakker, A.D., de Vries, T.J., Zandieh-Doulabi, B., Lobbezoo, F. & Everts, V. (2016). Juvenile porcine temporomandibular joint: three different cartilaginous structures? Archives of Oral Biology, vol 72, pp. 211- 218. DOI: 10.1016/j.archoralbio.2016.08.033 Tan, C.X.W., Brand, H.S., de Boer, N.K.H. & Forouzanfar, T. (2016). Gastrointestinal diseases and their orodental manifestations: part 1: Crohns disease. British Dental Journal, vol 221, no. 12, pp. 794-799. DOI: 10.1038/sj.bdj.2016.954 Tartaglione, G., Stoeckli, S.J., de Bree, R., Schilling, C., Flach, G.B., Bakholdt, V., Sorensen, J.A., Bilde, A., von Buchwald, C., Lawson, G., Dequanter, D., Villareal, P.M., Forcelledo, M.F.F., Amézaga, J.A., Moreira, A., Poli, T., Grandi, C., Vigli, M.G., ODoherty, M., Donner, D., Bloemena, E., Rahimi, S., Gurney, B., Haerle, S.K., Broglie, M.A., Huber, G.F., Krogdah, A.L., Sebbesen, L.R., Odell, E., Junquera Gutierrez, L.M.J., Barbier, L., Santamaria-Zuazua, .J, Jacome, M., Nollevaux, M.C., Bragantini, E., Lothaire, P., Silini, E.M., Sesenna, E., Dolivet, G., Mastronicola, R., Leroux, A., Sassoon, I., Sloan, P., Colletti, P.M., Rubello, D. & McGurk, M. (2016). Sentinel node in oral cancer: the nuclear medicine aspects. a survey from the sentinel european node trial. Clinical Nuclear Medicine, vol 41, no. 7, pp. 534-542. DOI: 10.1097/RLU.0000000000001241 Taslim, S.J., Leemans, C.R., van der Waal, I. & Karagozoglu, K.H. (2016). Follow-up of oral cancer patients: three uneventful years may be enough. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol 122, no. 4, pp. 434-439. DOI: 10.1016/j.oooo.2016.05.009 Tedesco, T.K., Bonifacio, C.C., Bissoto Calvo, A.F., Gimenez, T., Braga, M.M. & Raggio, D.P. (2016). Caries lesion prevention and arrestment in approximal surfaces in contact with glass ionomer cement restorations - a systematic review and meta-analysis. International Journal of Paediatric Dentistry, vol 26, no. 3, pp. 161- 172. DOI: 10.1111/ipd.12174 Ten Harkel, B., Koopsen, J., Putten, S.M., van Veen, H., Picavet, D.I., de Vries, T.J., Bank, R.A. & Everts, V. (2016). Ultrastructural aspects of foreign body giant cells generated on different substrates. Journal of Structural Biology, vol 195, no. 1, pp. 31-40. DOI: 10.1016/j.jsb.2016.04.016 Ter Heide, F.J.J., Mooren, T.M., van de Schoot, R., de Jongh, A. & Kleber, R.J. (2016). Eye movement desensitisation and reprocessing therapy v. stabilisation as usual for refugees: Randomised controlled trial. British Journal of Psychiatry, vol 209, no. 4, pp. 311-318. DOI: 10.1192/bjp.bp.115.167775 Timmer, F.C.A, Klop, W.M.C., Relyveld, G.N., Crijns, M.B., Balm, A.J.M., van den Brekel, M.W.M. & Lohuis, P.J.F.M. (2016). Merkel cell carcinoma of the head and neck: emphasizing the risk of undertreatment. European Archives of Oto-Rhino-Laryngology, vol 273, no. 5, pp. 1243-1251. DOI: 10.1007/s00405-015- 3558-0 Timmermans, A.J., Harmsen, H.J.M., Bus-Spoor, C., Buijssen, K.J.D.A., van As-Brooks, C., de Goffau, M.C., Tonk, R.H., van den Brekel, M.W.M., Hilgers, F.J.M. & van der Laan, B.F.A.M. (2016). Biofilm formation on the Provox ActiValve: Composition and ingrowth analyzed by Illumina paired-end RNA sequencing, fluorescence in situ hybridization, and confocal laser scanning microscopy. Head & Neck, vol 38, no. S1, pp. E432-E440. DOI: 10.1002/hed.24014 Timmermans, A.J., van Dijk, B.A.C., Overbeek, L.I.H., Velthuysen, M-L.F., van Tinteren, H., Hilgers, F.J.M. & van den Brekel, M.W.M. (2016). Trends in treatment and survival for advanced laryngeal cancer: a 20-year population-based study in the Netherlands. Head & Neck, vol 38, no. S1, pp. E1247-E1255. DOI: 10.1002/hed.24200 Toxopeus, A.H., Husebo, B.S., Strand, L.I., Delwel, S., van Wijk, A.J., Scherder, E.J.A. & Lobbezoo, F. (2016). The mouth care item of the MOBID pain scale: secondary analyses of unique video uptakes by dental professionals. Gerodontology, vol 33, no. 1, pp. 61-68. DOI: 10.1111/ger.12115

30 Academic Centre for Dentistry Amsterdam

Tuzuner, T., Turgut, S., Özen, B., Kılınç, H. & Bagis, B. (2016). Storing tooth segments for optimal esthetics Journal of Clinical Pediatric Dentistry, vol 40, no. 2, pp. 113-117. DOI: 10.17796/1053-4628-40.2.113 Tytgat, S.H.A.J., van Herwaarden, M.Y.A., Stolwijk, L.J., Keunen, K., Benders, M.J.N.L., de Graaff, J.C., Milstein, D.M.J., van der Zee, D.C. & Lemmers, P.M.A. (2016). Neonatal brain oxygenation during thoracoscopic correction of esophageal atresia. Surgical Endoscopy and other Interventional Techniques, vol 30, no. 7, pp. 2811-2817. DOI: 10.1007/s00464-015-4559-1 Valkenburg, C., Slot, D.E., Bakker, E.W. & van der Weijden, F.A. (2016). Does dentifrice use help to remove plaque? A systematic review Journal of Clinical Periodontology, vol 43, no. 1, pp. 1050-1058. DOI: 10.1111/jcpe.12615 Van den Berg, D.P.G., de Bont, P.A.J.M., van der Vleugel, B.M., de Roos, C., de Jongh, A., van Minnen, A. & van der Gaag, M. (2016). Trauma-focused treatment in PTSD patients with psychosis: symptom exacerbation, adverse events, and revictimization. Schizofrenia Bulletin, vol 42, no. 3, pp. 693-702. DOI: 10.1093/schbul/sbv172 Van den Berg, D.P.G., van der Vleugel, B.M., de Bont, P.A.J.M., Staring, A.B.P., Kraan, T., Ising, H., de Roos, C., de Jongh, A., van Minnen, A. & van der Gaag, M. (2016). Predicting trauma-focused treatment outcome in psychosis. Schizophrenia Research, vol 176, no. 2-3, pp. 239-244. DOI: 10.1016/j.schres.2016.07.016 Van den Berg, D.P.G., van der Vleugel, B.M., de Bont, P.A.J.M., Thijssen, G., de Roos, C., de Kleine, R., Kraan, T., Ising, H., de Jongh, A., van Minnen, A. & van der Gaag, M. (2016). Exposing therapists to trauma-focused treatment in psychosis: effects on credibility, expected burden, and harm expectancies. European Journal of Psychotraumatology, vol 7, 31712. DOI: 10.3402/ejpt.v7.31712 Van der Sluijs, E., Slot, D.E., Bakker, E.W.P. & van der Weijden, G.A. (2016). The effect of water on morning bad breath: a randomized clinical trial. International Journal of Dental Hygiene, vol 14, no. 2, pp. 124-134. DOI: 10.1111/idh.12149 Van der Sluijs, M, van der Sluijs, E, van der Weijden, F & Slot, D.E. (2016). The effect on clinical parameters of periodontal inflammation following non-surgical periodontal therapy with ultrasonics and chemotherapeutic cooling solutions: a systematic review Journal of Clinical Periodontology, vol 43, no. 12, pp. 1074-1085. DOI: 10.1111/jcpe.12613 Van der Tas, J.T., Elfrink, M.E.C., Vucic, S., Heppe, D.H.M., Veerkamp, J.S.J., Jaddoe, V.W.V., Rivadeneira, F., Hofman, A., Moll, H.A. & Wolvius, E.B. (2016). Association between bone mass and dental hypomineralization. Journal of Dental Research, vol 95, no. 4, pp. 396-401. DOI: 10.1177/0022034515625470 Van der Tas, J.T., Kragt, L., Veerkamp, J.S.J., Jaddoe, V.W.V., Moll, H.A., Ongkosuwito, E.M., Elfrink, M.E.C. & Wolvius, EB (2016). Ethnic disparities in dental caries among six-year-old children in the Netherlands. Caries Research, vol 50, no. 5, pp. 489-497. DOI: 10.1159/000448663 Van der Veen, M.H., Volgenant, C.M.C., Keijser, B., ten Cate, J.M. & Crielaard, W. (2016). Dynamics of red fluorescent dental plaque during experimental gingivitis-A cohort study. Journal of Dentistry, vol 48, pp. 71- 76. DOI: 10.1016/j.jdent.2016.02.010 Van der Waal, S.V., Connert, T., Crielaard, W.. & de Soet, J.J. (2016). In mixed biofilms Enterococcus faecalis benefits from a calcium hydroxide challenge and culturing. International Endodontic Journal, vol 49, no. 9, pp. 865-873. DOI: 10.1111/iej.12542 Van Dijk, A., van Eldik, M., Veldhuizen, E.J.A., Tjeerdsma-van Bokhoven, H.L.M., de Zoete, M.R., Bikker, F.J. & Haagsman, H.P. (2016). Immunomodulatory and anti-inflammatory activities of chicken cathelicidin-2 derived peptides. PLoS One, vol 11, no. 2, e0147919. DOI: 10.1371/journal.pone.0147919 Van Eekeren, P.J.A., Aartman, I.H.A., Tahmaseb, A. & Wismeijer, D. (2016). The effect of implant placement in patients with either Kennedy class II and III on oral health-related quality of life: A prospective clinical trial. Journal of Oral Rehabilitation, vol 43, no. 4, pp. 291-296. DOI: 10.1111/joor.12370 Van Leeuwen, P.T., van der Peet, J.M., Bikker, F.J., Hoogenkamp, M.A., Oliveira Paiva, A.M., Kostidis, S., Mayboroda, O.A., Smits, W.K. & Krom, B.P. (2016). Interspecies Interactions between Clostridium difficile and Candida albicans. mSphere, vol 1, no. 6, e00187-16. DOI: http://dx.doi.org/10.1128/mSphere.00187-16 Van Loveren, C. & van Palenstein Helderman, W. (2016). EAPD interim seminar and workshop in Brussels May 9 2015 Non-invasive caries treatment. European Archives of Paediatric Dentistry, vol 17, no. 1, pp. 33-44. DOI: 10.1007/s40368-015-0219-3 Van Minnen, A., van der Vleugel, B.M., van den Berg, D.P.G., de Bont, P.A.J.M., de Roos, .C, van der Gaag, M. & de Jongh, A. (2016). Effectiveness of trauma-focused treatment for patients with psychosis with and without the dissociative subtype of post-traumatic stress disorder. British Journal of Psychiatry, vol 209, no. 4, pp. 347-348. DOI: 10.1192/bjp.bp.116.185579

31 Annual Research Report 2016

Van Monsjou, H.S., Schaapveld, M., Hamming-Vrieze, O., de Boer, J.P., van den Brekel, M.W.M. & Balm, A.J.M. (2016). Cause-specific excess mortality in patients treated for cancer of the oral cavity and oropharynx: a population-based study. Oral Oncology, vol 52, pp. 37-44. DOI: 10.1016/j.oraloncology.2015.10.013 Van Wijk, A.J., Molendijk, G. & Verrips, G.H.W. (2016). OHRQoL in a sample of alcohol and drug abusers. The Open Dentistry Journal, vol 10, pp. 338-346. DOI: 10.2174/1874210601610010338 Vanneste, B.G.L., Lopez-Yurda, M., Tan, I.B., Balm, A.J.M., Borst, G.R. & Rasch, C.R. (2016). Irradiation of localized squamous cell carcinoma of the nasal vestibule. Head & Neck, vol 38, no. S1, pp. E1870-E1875. DOI: 10.1002/hed.24337 Venekamp, R.P., Burton, M.J., van Dongen, T.M.A., van der Heijden, G.J., van Zon, A. & Schilder, A.G.M. (2016). Antibiotics for otitis media with effusion in children. Cochrane Database of Systematic Reviews, vol 6, CD009163. DOI: 10.1002/14651858.CD009163.pub3 Volgenant, C.M.C., Fernandez y Mostajo, M., Rosema, N.A.M., van der Weijden, F.A., ten Cate, J.M. & van der Veen, M.H. (2016). Comparison of red autofluorescing plaque and disclosed plaque-a cross-sectional study. Clinical Oral Investigations, vol 20, no. 9, pp. 2551-2558. DOI: 10.1007/s00784-016-1761-z Volgenant, C.M.C., Hoogenkamp, M.A., Buijs, M.J., Zaura, E., ten Cate, J.M. & van der Veen, M.H. (2016). Red fluorescent biofilm: the thick, the old, and the cariogenic. Journal of Oral Microbiology, vol 8, 30346. DOI: 10.3402/jom.v8.30346 Volgenant, C.M.C., Hoogenkamp, M.A., Krom, B.P., Janus, M.M., ten Cate, J.M., de Soet, J.J., Crielaard, W. & van der Veen, M.H. (2016). Red and green fluorescence from oral biofilms. PLoS One, vol 11, no. 12, e0168428. DOI: 10.1371/journal.pone.0168428 Vucic, S., Drost, R.W., van Wijk, A.J., Wesselink, P.R. & Wolvius, E.B. (2016). Patterns of orodental injury and mouthguard use in Dutch field hockey. British Journal of Sports Medicine, vol 50, no. 11, pp. 661-668. DOI: 10.1136/bjsports-2015-095677 Wan, Q., Schoenmaker, T. Jansen, I.D.C., Bian, Z., de Vries, T.J. & Everts, V. (2016). Osteoblasts of calvaria induce higher numbers of osteoclasts than osteoblasts from long bone. Bone, vol 86, pp. 10-21. DOI: 10.1016/j.bone.2016.02.010 Willems, H.M., Kos, K., Jabra-Rizk, M.A. & Krom, B.P. (2016). Candida albicans in oral biofilms could prevent caries. Pathogens and Disease, vol 74, no. 5, ftw039. DOI: 10.1093/femspd/ftw039 Wondergem, M., Lieben, G., Bouman, S., van den Brekel, M.W.M. & Lohuis, P.J.F.M. (2016). Patients satisfaction with facial prostheses. British Journal of Oral & Maxillofacial Surgery, vol 54, no. 4, pp. 394-399. DOI: 10.1016/j.bjoms.2016.09.011 Yönel, N., Bikker, F.J., Lagerweij, M.D., Kleverlaan, C.J., van Loveren, C., Özen, B., Çetiner, S. & van Strijp, A.J.P. (2016). Anti-erosive effects of fluoride and phytosphingosine: an in vitro study. European Journal of Oral Sciences, vol 124, no. 4, pp. 396-402. DOI: 10.1111/eos.12283 Zandbergen, D., Slot, D.E., Niederman, R. & van der Weijden, F.A. (2016). The concomitant administration of systemic amoxicillin and metronidazole compared to scaling and root planing alone in treating periodontitis: a systematic review. BMC Oral Health, vol 16, 27. DOI: 10.1186/s12903-015-0123-6 Zecha, J.A.E.M., Raber-Durlacher, J.E. Nair, R.G., Epstein, J.B., Elad, S., Hamblin, M.R., Barasch, A., Migliorati, C.A., Milstein, D.M.J., Genot, M.T., Lansaat, L., van der Brink, R., Arnabat-Dominguez, J., van der Molen, L., Jacobi, I., van Diessen, J., de Lange, J., Smeele, L.E., Schubert, M.M. & Bensadoun, R.J. (2016). Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols. Supportive Care in Cancer, vol 24, no. 6, pp. 2793-2805. DOI: 10.1007/s00520-016-3153-y Zecha, J.A.E.M., Raber-Durlacher, J.E., Nair, R.G., Epstein, J.B., Sonis, S.T., Elad, S., Hamblin, M.R., Barasch, A., Migliorati, C.A., Milstein, D.M.J., Genot, M.T., Lansaat, L., van der Brink, R., Arnabat-Dominguez, J., van der Molen, L., Jacobi, I., van Diessen, J., de Lange, J., Smeele, L.E., Schubert, M.M. & Bensadoun, R.J. (2016). Low level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations. Supportive Care in Cancer, vol 24, no. 6, pp. 2781-2792. DOI: 10.1007/s00520-016-3152-z Zemouri, C., Wi, T.E., Kiarie, J., Seuc, A., Mogasale, V., Latif, A. & Broutet, N. (2016). The performance of the vaginal discharge syndromic management in treating vaginal and cervical infection: A systematic review and meta-analysis. PLoS One, vol 11, no. 10, e0163365. DOI: 10.1371/journal.pone.0163365 Zhang, M., Wang, R., Liao, Y., Buijs, M.J. & Li, J. (2016). Profiling of oral and nasal microbiome in children with cleft palate. Cleft Palate-Craniofacial Journal, vol 53, no. 3, pp. 332-338. DOI: Profiling of oral and nasal microbiome in children with cleft palate.

32 Academic Centre for Dentistry Amsterdam

Zygogiannis, K., Wismeijer, D., Aartman, I.H.A. & Osman, R.B. (2016). A systematic review on immediate loading of implants used to support overdentures opposed by conventional prostheses: factors that might influence clinical outcomes. International Journal of Oral & Maxillofacial Implants, vol 31, no. 1, pp. 63-72. DOI: 10.11607/jomi.4028

Other scientific publications Balta, G.M., Boloori, E., Nikolaou, C.F., Loos, B.G. & van der Velden, U. (2016). Paper Digest. Journal of Clinical Periodontology 2016:43: 02 (Sharma et al. Association between periodontitis and mortality in stages 3-5 chronic kidney disease: NHANES III and linked mortality study. J Clin Periodontol. 2016 Feb;43(2):104-113) Journal of Clinical Periodontology, vol 43, no. 2. Bizzarro, S. (2016). Critical appraisal on the prevalence of prediabetes, diabetes mellitus and cardiovascular risk in patients with periodontitis. International Journal of Evidence-Based Practice for the Dental Hygienist, vol 2, no. 2, pp. 116-118. DOI: 10.11607/ebh.69 Brand, H.S. (2016). Sweeth tooth: What pocket money is buying today. Expert view British Dental Journal, vol 221, no. 2, pp. 18-19. DOI: 10.1038/sj.bdj.2016.490 De Jongh, A. (2016). EMDR therapy for specific fears and phobias: the phobia protocol. in M. Luber (ed.), Eye movement desensitization and reprocessing: EMDR therapy: scripted protocols and summary sheets: treating anxiety, obsessive-compusive, and mood-related conditions. Springer Publishing, New York, pp. 9- 39. Den Dekker, J. (2016). Sociale Tandheelkunde in de praktijk. 2e druk edn, Prelum, Houten. Groisman, S., Jardim, J.J., Maltz, M. & van der Veen, M.H. (2016). Diagnóstico da cárie dentária. Capítulo 6. in M. Maltz, L.M.A. Tenuta, S. Groisman & J.A. Cury (eds), Cariologia: conceitos básicos, diagnósticos e tratamento não restaurador. (Série Abeno: Odontologia Essencial - Parte Clínica). Artes Médicas, São Paulo, pp. 66-74. Hennequin-Hoenderdos, N.L., Slot, D.E. & van der Weijden, G.A. (2016). Respond to the letter of McIsaac. (2015) International Journal of Dental Hygiene, vol 14, no. 1, pp. 76. DOI: 10.1111/idh.12186 Hesse, D., Bonifacio, C.C., A.B. Guglielmi, C.D., da Franca, C., Mendes, F.M. & Raggio, D.P .(2016). Answer to the letter Complete clinical retention of sealant materials should not be contemplated as cut-off for clinical success. Braz. Oral Res. 2016;30:e32. doi: 10.1590/1807-3107BOR-2016.vol30.0032 Brazilian Oral Research, vol 30, no. 1, e57. DOI: 10.1590/1807-3107BOR-2016.vol30.0057 Horst, F. & de Jongh, A. (2016). EMDR therapy protocol for panic disorders with or without agoraphobia. in M. Luber (ed.), Eye movement desensitization and reprocessing: EMDR therapy: scripted protocols and summary sheets: treating anxiety, obsessive-compusive, and mood-related conditions. Springer Publishing, New York, pp. 51-69. Krom, B.P. & Willems, H.M.E. (2016). In vitro models for Candida biofilm development. in R. Calderone & R. Cihlar (eds), Candida species: methods and protocols. Methods in molecular biology, no. 1356, Humana Press, New York, pp. 95-105. DOI: 10.1007/978-1-4939-3052-4_8 Loos, B.G., Teeuw, W.J. & Nicu, E.A. (2016). Plausible mechanisms explaining the association of periodontitis with cardiovascular diseases. in A.M.L. Petersen (ed.), Oral infections and general health book: From molecule to chairside. Part II edn, Springer International Publishing Switzerland, pp. 19-33. DOI: 10.1007/978-3-319-25091-5_3 Mevissen, L., Didden, R. & de Jongh, A. (2016). Assessment and treatment of PTSD in people with intellectual disabilities. in C.R. Martin, V.R. Preedy & V.B. Patel (eds), Comprehensive guide to Post-Traumatic Stress Disorders. 1st edn, vol. 3, Springer Publishing, Switzerland, pp. 281-299. DOI: 10.1007/978-3-319-08359- 9_95 Patel, S., Harvey, S., Shemesh, H. & Durack, C. (2016). Cone Beam Computed Tomography in Endodontics. 1 edn, Quintessence Publishing Co. Inc. Scheres, C.R. & Krom, B.P. (2016). Staphylococcus-Candida interaction models: antibiotic resistance testing and host interactions. in R. Calderone & R. Cihlar (eds), Candida species: methods and protocols. Methods in molecular biology, no. 1356, Humana Press, New York, pp. 153-161. DOI: 10.1007/978-1-4939-3052- 4_11 Slot, D.E., Mettes, T.D. & van der Weijden, F. (2016). Research methods. The Journal of the American Dental Association, vol 147, no. 4, pp. 231-3. DOI: 10.1016/j.adaj.2016.02.007 Ter Heide, F.J.J., Mooren, T.M. de Jongh, A. & Kleber, R.J. (2016). Authors reply. British Journal of Psychiatry, vol 209, no. 1, pp. 85-86. DOI: 10.1192/bjp.209.1.84a

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Professional publications Alansari, S. (2016). Osteonecrose van de kaak door bisfosfonaten en andere medicatie. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 11, no. 4, pp. 30-34. Al-Maliky, S., Hennequin-Hoenderdos, N.L., van der Sluijs, E., Slot, D.E., Keijser, B.J.F. & van der Weijden, G.A. (2016). Mondhygiënegedrag van een groep gezonde studenten. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 6, pp. 295-302. DOI: 10.5177/ntvt.2016.06.15238 Baart, J.A. & van der Waal, I. (2016). Het focusvrij maken van de mond. Quality Practice Assistenten, vol 3, no. 2, pp. 14-17. Baart, J.A. & van der Waal, I. (2016). Röntgendiagnostiek in de kaakchirurgie: enkele voorbeelden. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 11, no. 5, pp. 39-44. Beerens, M.W. & van der Veen, M.H. (2016). Detectie en preventie van wittevleklaesies tijdens en na de orthodontische behandeling met vaste apparatuur. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 12, no. 3, pp. 20-25. Beukers, N., Loos, B., van Wijk, A. & van der Heijden, G.J.M.G. (2016). Associatie tussen parodontitis en hart- en vaatziekten. Rubriek Uitgelezen Nederlands Tandartsenblad, vol 19, no. 11, pp. 22. Bicanic, I. & de Jongh, A. (2016). De effectiviteit van EMDR therapie bij slachtoffers van seksueel geweld. EMDR Magazine, vol 3, no. 12, pp. 48-49. Bicanic, I. & de Jongh, A. (2016). EMDR in Amerikaanse Rape Crisis Centers. EMDR Magazine, vol 3, no. 12, pp. 50. Bicanic, I. & de Jongh, A. (2016). Waarom mensen gapen na EMDR. EMDR Magazine, vol 2, no. 11, pp. 68. Bicanic, I. & de Jongh, A. (2016). Yvonne van Riemsdijk vertelt over satanisch ritueel misbruik. EMDR Magazine, vol 3, no. 12, pp. 30-34. Bicanic, I., de Jongh, A., Lagro-Janssen, T. & Leusink, P. (2016). Centra Seksueel Geweld voor acute slachtoffers. Huisarts en Wetenschap, vol 59, no. 6, pp. 265-267. Bonifacio, C.C. (2016). Micro-invasieve behandeling van approximale cariës: de infiltratietechniek. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, vol 8, no. 3, pp. 30-33. Brand, H. (2016). Een patiënt met een ICD. De Tandartspraktijk, vol 37, no. 1, pp. 43-47. DOI: 10.1007/s12496- 016-0012-4 Brand, H. (2016). Een patiënt met een pacemaker: van slag door tandheelkundige apparatuur? De Tandartspraktijk, vol 37, no. 4, pp. 28-31. DOI: 10.1007/s12496-016-0050-y Brand, H. (2016). Verbeelding: pardon us. Nederlands Tandartsenblad, vol 71, no. 19, pp. 8. Brand, H. (2016). Verbeelding: snow dogs. Nederlands Tandartsenblad, vol 71, no. 15, pp. 8. Brand, H.S. (2016). Afscheidscollege prof. dr. D.B. Tuinzing. Meer dan op het eerste gezicht. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 8, pp. 8-9. Brand, H.S., Bots, C.P. & Schulte, P.F.J. (2016). Mondgezondheid van patiënten met een bipolaire stoornis. Quality Practice Assistenten, vol 4, no. 1, pp. 14-18. Braun, A.K. (2016). Complicerende factoren tijdens een endodontische herbehandeling: tips en trucs om endodontische materialen te verwijderen. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 11, no. 3, pp. 34-43. Braun, A.K., Le, N.T.P. & de Groot-Kuin, D. (2016). De endodontische vulling aan de hand van drie individuele casussen. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 11, no. 3, pp. 20-25. Cohenca, N. & Shemesh, H. (2016). Klinische toepassingen van CBCT binnen de endodontie: een uitgebreid overzicht. Deel 2: Toepassingen in verband met uitgebreide endodontische problemen en complicaties. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 11, no. 4, pp. 39-49. Cristescu, R., Marques, M.S., Feiz Barazandeh, A. & Moinzadeh, A. (2016). Obturatie van het wortelkanaalstelsel met vier verschillende technieken. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 11, no. 3, pp. 13-19. Danser, M. & Thomas, R. (2016). Parodontitis en de algemene gezondheid: Wat is de impact van parodontitis op de rest van het lichaam? De Tandartspraktijk, vol 37, no. 7, pp. 24-27. DOI: 10.1007/s12496-016-0091-2 De Jongh, A. & Bicanic, I. (2016). Hoe behandel je een patiënt met een genitale respons na seksueel misbruik. Deel 1. EMDR Magazine, vol 3, no. 12, pp. 53-55. De Jongh, A. (2016). Angst voor de tandarts. EMDR Magazine, vol 1, no. 10, pp. 53-54. De Jongh, A. (2016). De mooie plaatjes van vroeger zijn verdwenen. EMDR Magazine, vol 3, no. 12, pp. 60-61. De Jongh, A. (2016). EMDR gericht op dromen over vroeger. EMDR Magazine, vol 2, no. 11, pp. 64-69. De Jongh, A. (2016). Geen beelden.... EMDR Magazine, vol 2, no. 11, pp. 58-59.

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De Jongh, A. (2016). Hallucinaties na EMDR. Iets om je zorgen over te maken? EMDR Magazine, vol 3, no. 12, pp. 59. De Jongh, A. (2016). Schuldgevoel na verkrachtingen. EMDR Magazine, vol 1, no. 10, pp. 54-57. De Jongh, A. (2016). Wachten met EMDR vanwege een bestaande bedreiging? EMDR Magazine, vol 2, no. 11, pp. 60-61. De Jongh, A., Bicanic, I. & Eimers, D. (2016). Verhalen over satanisch en ritueel misbruik: Hoe moeten we er mee omgaan? EMDR Magazine, vol 3, no. 12, pp. 36-41. De Jong-Lenters, M. (2016). Hora est 7. Is positiviteit het geheime ingrediënt? Cariës, overgewicht en probleemgedrag bij kinderen: de rol van ouders en het gezin. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 11, pp. 554-556. DOI: 10.5177/ntvt.2016.11.16213 De Soet, J.J. & Zaura, E. (2016). Cariës - een oplosbare ecologische catastrofe? Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, vol 8, no. 3, pp. 7-11. De Visscher, J.G.A.M. (2016). Gehoorschade door kankerbehandeling. [Bespreking van: E.A.R. Theunissen (2015) Treatment induced hearing loss after (chemo) radiotherapy in patients with head and neck cancer]. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 1, pp. 57. Donders, H.C.M., Berkhout, W.E.R. & de Lange, J. (2016). Röntgenraadsels. Solitaire of multiple radio- opaciteit? Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 11, no. 3, pp. 51. Eijkman, M.A.J. (2016). Afscheidsrede prof. dr. I. van der Waal. Een witte plek in de mond; wat te doen? Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 7/8, pp. 342. Eijkman, M.A.J. (2016). Afscheidsrede prof.dr. C.de Putter. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 5, pp. 396. Eijkman, M.A.J. (2016). De Hongaarse patiënt: Tandartsverhalen afl. 1. Dental Tribune, vol 5, pp. 23. Eijkman, M.A.J. (2016). De verliefde oude heer: Tandartsverhalen afl. 3. Dental Tribune, vol 7, pp. 23. Eijkman, M.A.J. (2016). De verwijtbare gemiste diagnose. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 3, pp. 119. Eijkman, M.A.J. (2016). De vijlloze endo. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 5, pp. 581. Eijkman, M.A.J. (2016). De vitale pulpa. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 5, pp. 237. Eijkman, M.A.J. (2016). Haute couture: Tandartsverhalen afl. 5. Dental Tribune, vol 9, pp. 31. Eijkman, M.A.J. (2016). Het gelaat van een medicus. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 3, pp. 125. Eijkman, M.A.J. (2016). Niet meer de oude: Tandartsverhalen afl. 6. Dental Tribune, vol 10, pp. 31. Eijkman, M.A.J. (2016). Oppassen, dokter: Tandartsverhalen afl. 2. Dental Tribune, vol 6, pp. 23. Eijkman, M.A.J. (2016). Witte tandjes voor Luuk: Tandartsverhalen afl. 4 Dental Tribune, vol 8, pp. 31. El Haddouchi, F., de Jongh, A. & Broers, D.L.M. (2016). Het rubinstein-taybisyndroom: Een casus. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 11, no. 4, pp. 35-38. Gambon, D. (2016). Help! Mijn kind wil niet poetsen. De Tandartspraktijk, vol 37, no. 5, pp. 16-20. DOI: 10.1007/s12496-016-0061-8 Gambon, D. (2016). Het kind bij de tandarts: Als je flink bent, krijg je een beloning! De Tandartspraktijk, vol 37, no. 7, pp. 18-23. DOI: 10.1007/s12496-016-0090-3 Gambon, D. (2016). Preventie, tandpastas en spoelmiddelen. De Tandartspraktijk, vol 37, no. 1, pp. 37-41. DOI: 10.1007/s12496-016-0011-5 Gambon, D. (2016). Probleem, uitdaging of koud kunstje: Het (hele) jonge kind bij de tandarts. De Tandartspraktijk, vol 37, no. 6, pp. 43-47. DOI: 10.1007/s12496-016-0081-4 Gambon, D. (2016). Zwarte verkleuringen in het kindergebit. De Tandartspraktijk, vol 37, no. 3, pp. 22-25. DOI: 10.1007/s12496-016-0034-y Gambon, D.L. (2016). Sport- en energiedranken in relatie tot tanderosie. Quality Practice Assistenten, vol 4, no. 1, pp. 13-18. Gambon, D.L. (2016). Sport- en energiedranken in relatie tot tanderosie. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 12, no. 1, pp. 26-30. Gambon, D.L (2016). Zuigflescariës: Het pyjamapapje een nieuw fenomeen!? De Tandartspraktijk, vol 37, no. 10, pp. 22-28. DOI: 10.1007/s12496-016-0133-9 Gorter, R.C. (2016). De psychologie van samenwerken. Quality Practice Assistenten, vol 4, no. 1, pp. 25-28. Jonkman, J., Jongen, L., & Eijkman, M. (2015). Helse Mondklachten. Kiespijn en andere mondproblemen in de Middeleeuwen. Madoc, 29(4), 208-218. Kind, L.S., van Gemert-Schriks, M.C.M. & Elhorst, J.H. (2016). Autismevriendelijke tandheelkundige zorg. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 2, pp. 73-77. DOI: 10.5177/ntvt.2016.02.15182

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Koopmans, J. & de Jongh, A. (2016). Behandelsessie van een jonge vrouw met ernstige PTSS na langdurig en extreem seksueel geweld. EMDR Magazine, vol 3, no. 12, pp. 10-13. Laheij, A.M.G.A. & Volgenant, C.M.C. (2016). De volgorde van het aan- en uittrekken van de persoonlijke beschermingsmiddelen. Quality Practice Assistenten, vol 4, no. 1, pp. 50. Laine, M.L. (2016). Mittausten perusteella hyvin hoidettu. Appolonia. Loos, B.G. (2016). Mondinfecties en atherosclerotische hart- en vaatziekten. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, vol 8, no. 2, pp. 32-40. Louropoulou, A., Schoolderman, H. & van der Weijden, F. (2016). Preventie en behandeling van peri- implantaire infecties Nazorg uit voorzorg Dentista : magazine voor het tandheelkundig team, pp. 3-5. Mevissen, L., Didden, R. & de Jongh, A. (2016). EMDR therapie voor posttraumatische stressstoornis bij kinderen en adolescenten met een licht verstandelijke beperking: Een multiple baseline studie. Directieve Therapie, vol 36, no. 3, pp. 169-183. Mevissen, L., Didden, R. & de Jongh, A. (2016). EMDR voor trauma- en stressorgerelateerde klachten bij patiënten met een verstandelijke beperking: overzicht en casusbespreking. Directieve Therapie, vol 36, no. 1, pp. 5-26. Mevissen, L., Didden, R., & de Jongh, A. (2016). Eye movement desensitization and reprocessing (EMDR). in R. Didden, P. Troost & X. Moonen (Eds). Handboek psychiatrie en lichte verstandelijke beperking. 1 edn, De Tijdstroom, Utrecht, pp. 409-424. Mevissen, L., Didden, R., & de Jongh, A. (2016). Posttraumatische-stressstoornis (PTSS). in R. Didden, P. Troost & X. Moonen (Eds). Handboek psychiatrie en lichte verstandelijke beperking. 1 edn, De Tijdstroom, Utrecht, pp. 171-184. Neelakantan, P., Shemesh, H. & Wesselink, P. (2016). Hora est 4. Interacties tussen irrigatie-oplossingen, wortelkanaalcementen en dentine. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 9, pp. 425-427. DOI: 10.5177/ntvt.2016.09.16178 Parisius, K.G.H., Wartewig, E., Jansen, B.J. & van Loveren, C. (2016). Geen fluoride alstublieft! Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, vol 9, no. 1, pp. 54-56. Raber-Durlacher, JE, Slief, RIC, Geuke, M & Hazenberg, MD (2016). Chronische orale graft-versus-hostziekte Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 11, no. 4, pp. 22-28. Rijken, J.A., van Nieuwkerk, E.B.J., Bloemena, E. & Eerenstein, S.E.J. (2016). Pleiomorf adenoom uitgaande van de kleine speekselklieren. Nederlands tijdschrift voor Keel- Neus- en Oorheelkunde, vol 22, pp. 123-126. Rosema, N.A.M. & van Palenstein Helderman, W.H. (2016). Goede mondhygiëne: een wereldwijd streven. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 12, no. 1, pp. 18-21. Rosema, NAM (2016). Tandenpoetsen anno nu. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, vol 8, no. 2, pp. 15-18. Rozema, F.R. (2016). Antibiotica en infecties in de tandheelkundige praktijk. [Bespreking van: L. Abraham- Inpijn (2016). Antibiotica en infecties. Antibiotica in de tandheelkundige praktijk]. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 11, pp. 567. Rozema, F.R. (2016). Behandeling van traumata in het orofaciale gebied. [Bespreking van: M. Perry, A. Brown, P. Banks (2015) Fractures of the facial skeleton, second edition]. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 2, pp. 113. Rozema, F.R. (2016). Nikkel- en palladiumafgifte. [Bespreking van: A.M. Ventura da Cruz Rodriques Milheiro (2015) Exposure to nickel and palladium from dental appliances]. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 5, pp. 271. Said Afellad, S., de Jongh, A., & Pieterse, C. M. (2015). Een patiënt met Somatisch Onvoldoende verklaarde Lichamelijke Klachten (SOLK). Quality Practice. Nascholingstijdschrift voor Tandartsen, 11(2), 42-46. Teeuw, W.J. (2016). Ernstige parodontitis moet je interdisciplinair behandelen. Nederlands Tandartsenblad, vol 71, no. 18, pp. 8. Valkenburg, C., Slot, D.E. & van der Weijden, F. (2016). Het nut van tandpasta bij het verwijderen van tandplaque. Nederlands Tandartsenblad, vol 71, no. 17, pp. 18-19. Van der Waal, I. (2016). Tand- en mondpathologie. [Bespreking van: P.J. Slootweg (2016). Dental and Oral Pathology]. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 11, pp. 568. Van der Waal, S.V. (2016). Behandeling van pijn van endodontische oorsprong. Antibiotica helpen niet bij endodontische pijn. Wat wel? De Tandartspraktijk, vol 37, no. 9, pp. 27-30. Van der Weijden, F. & Andreotta, S. (2016). Een vreemde casus. Een vreemd lichaam. Dentista: magazine voor het tandheelkundig team. Van der Weijden, F. & Berkhout, E. (2016). De gerechtvaardigde röntgenfoto. Dentista: magazine voor het tandheelkundig team, vol 13, pp. 13-15.

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Van der Weijden, F. & Doornik, T. (2016). Bewegingsstoornis als bijwerking van medicatie:. Tardieve dyskinesie. Dentista magazine voor het tandheelkundig team, pp. 3-5. Van der Wouden, P., Shemesh, H. & van der Heijden, G. (2016). Kloof tussen praktijk en wetenschap overbruggen: Kennisagenda Mondzorg Scientific Dentistry United, vol 2, pp. 19-21. Van der Zande, M.M., Gorter, R.C., Wismeijer, D. & van der Heijden, G.J.M.G. (2016). Vernieuwingen in de praktijk. Rubriek Uitgelezen Nederlands Tandartsenblad, vol 71, no. 14, pp. 18. Van Loveren, C. (2016). Modern cariësmanagement. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, vol 8, no. 3, pp. 12-18. Van Loveren, C. & Lagerweij, M. (2016). Tandhalsgevoeligheid. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, vol 8, no. 2, pp. 7-14. Van Spreuwel, P, Jerković-Ćosić, K., van Loveren, C. & van der Heijden, G.J.M.G. (2016). Zorg voor het kindergebit. Rubriek Uitgelezen Nederlands Tandartsenblad, vol 9, no. 5, pp. 24. Voogt, L., Louropoulou, A. & van Pelt, H. (2016). Hopeloos verloren en toch bruikbaar: Extraheren, zandstralen van het worteloppervlak en terugplaatsen. De Tandartspraktijk, vol 37, no. 7, pp. 4-9. DOI: 10.1007/s12496- 016-0087-y Walenkamp, G.H.I.M., Moojen, D.J.F., Hendriks, J.G.E., Rozema, F.R., Goedendorp, T.A. & Rademacher, W.M.H. (2016). Richtlijn Antibioticaprofylaxe bij patiënten met een gewrichtsprothese. Nederlandse Orthopaedische Vereniging (NOV), s-Hertogenbosch. Warnsinck, C.J. & Shemesh, H. (2016). De periapicale laesie op langere termijn. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 11, no. 3, pp. 7-12. Warnsinck, C.J & Shemesh, H (2016). Endodontologie in beweging: nieuwe concepten, materialen en technieken 5. De dynamiek van de periapicale laesie. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 1, pp. 44-48. DOI: 10.5177/ntvt.2016.01.15214

Publications for the general public Danser, M. M. (2015). Tandenpoetsen kinderen? Telegraaf, gezondheidsrubriek, 5. Danser, M. M. (2015). Hartprobleem door slecht gebit? Telegraaf, gezondheidsrubriek, 5. Danser, M. M. (2015). Verband met parodontitis? Telegraaf, gezondheidsrubriek, 5. Danser, M. M. (2015). Parodontitis erfelijk? Telegraaf, gezondheidsrubriek, 5. Danser, M. M. (2015). Invloed dieet op tandvlees? Telegraaf, gezondheidsrubriek, 5. Eijkman, M.A.J. (2016). Tandarts kan versleten gebit restaureren. NRC Weekend Wetenschap. Ten Cate, J.M. (2016). Maakt ACTA kans op de Nobelprijs? Factaal, vol 16, no. 3, pp. 6-7. Van der Waal, S.V. (2016). Antibiotica voorschrijven is niet onschuldig. Factaal, vol 16, no. 3, pp. 18-19.

Grants: current projects with external funding Bloemena, E. Optimizing access to personalized cancer therapy in The Netherlands; from tissue to therapy. ZonMW call Personalized treatment 2015, participant (2015, January 01 - 2016, December 31). Bolscher, J.G.M. Co‐investigator of research project: Starvation response, biofilm formation and drug tolerance in Burkholderia pseudomallei, granted by the Thailand Research Fund through the Royal Golden Jubilee Ph.D. Program (Grant no. PHD/0351/2551) during 6 years (2010-2016). Granted total 1,555,000 Thai baht; covering PhD‐student MSc. A. Chitchanok visits to ACTA and visits of co‐investigator to Khon Kaen University. Principal Investigator: prof.dr. S. Taweechaisupapong, Faculty of Dentistry, Department of Oral Diagnosis, Khon Kaen University, Thailand (2010, January 01 - 2016, December 31). Bolscher, J.G.M. & Veerman, E.C.I. Co-investigators project: Applying histatin-1 to improve integration of dental implants. ITI research grant (International team for Implantology). Grant no. 1091-2015, during six months 2015-2016, (€ 37607). Principal Investigator: dr. J. Stap, Core facility Cellular Imaging / LCAM-AMC, Academic Medical Center, University of Amsterdam: (2015, January 01 - 2016, December 31). Crielaard, W. (collaborator) Collaboration research on anti-caries biomaterials containing nanoparticles International Science and Technology Cooperation Program of China (2014DFE30180). Granted 1.22 million RMB. Principal investigators: Xuedong Zhou (PI), Lei Cheng, Jiyao Li. Collaborators: ACTA, the Netherlands; Saarland University, Germany (2014, November 01, 2016, November 01). Crielaard, W. & Loos, B.G. Preventive Dentistry, Periodontology, Oral Biochemistry, Cariology, TIFN Oral Health. Public Private Partnership funded by the Dutch Ministry of Economic Affairs, Wrigley, Philips

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Research, Cargill, GlaxoSmithKline, TNO, WUR & ACTA (total investment 5.2 M€): (2012, January 01 - 2016, September 01). Crielaard, W., Buijs, M.J., Brandt, B.W. & Zaura, E. The microbiome associated with equine periodontitis and oral health. Collaborative Research with Dental School, University of Glasgow, United Kingdom, granted: GBP 14.000: (2015, January 01 – 31 December 2016). Crielaard, W., Buijs, M.J., Brandt, B.W. & Zaura, E. Subgingival microbiome in relation to periodontal health. Collaborative Research with Faculty of Medicine and Dentistry, Department of Clinical Dentistry, University of Bergen, Bergen, Norway, granted €15.000: (2016, January 01 – 2017, December 31). Crielaard, W., Buijs, M.J. & Brandt, B.W. Amplicon sequencing of oral samples. Commissioned Research Glasgow Dental School, University of Glasgow, United Kingdom, granted: GBP 20.000 excl. VAT: (2016, September – 2017, September). Crielaard, W. & Krom, B.P. Studying dynamics in complex microbial biofilms. NWO Middelgroot, granted €164.000: (2013, January 01 - 2017, January 01). Deng, D.M. & Wu, G. Application of a novel local antimicrobial delivery and osteconductive system on decontaminated implant surfaces to promote re-osseointegration. ITI Foundation research grant, 1034_2014 (Principal investigator) (01-07-2015 till 30-06-2017), granted €37.798 (2015, July 01 - 2017, June 30). De Soet, J.J. & Laheij, A.M.G.A. (collaborators). The influence of the oral microbiome and salivary proteome on oral complications in hematopoietic stem cell transplantation recipients: H-OME study. Granted 563.100 Euro. Principal investigators: J.E. Raber, F.R. Rozema & N.M.A. Blijlevens (2015, May 1 – 2019, May 1). Exterkate, R.A.M. & Crielaard, W. Effect of S-PRG eluent on in-vitro biofilms - Part II Commissioned Research Shofu Inc. Japan, granted €22.000 (February 2016). Exterkate, R.A.M. & Crielaard, W. Effect of S-PRG eluent on in-vitro biofilms - Part II - Data on composition of biofilms. Commissioned Research Shofu Inc. Japan, granted €6.000 (August 2016). Exterkate, R.A.M. & Crielaard, W. The effect of S-PRG particles on biofilm development and activity. Commissioned Research Shofu Inc. Japan, granted €18.000 (August 2016). Exterkate, R.A.M., de Wit, W.E.A.J. & Crielaard, W. The effect of lactate and lactylate variants on saliva derived biofilm growth, survival and behaviour. Commissioned Research Corbion, granted €18.000 (June 2016). Jager, D.H.J. A randomized, double blind (sponsor open), comparative, multi-center study to evaluate the safety and efficacy of subcutaneous belimumab (GSK1550188) and intravenous rituximab co- administration in subjects with primary Sjögren’s syndrome. GlaxoSmithKline plc. Granted €114.000,- (2015-2016). Jager, D.H.J. & Forouzanfar, T. Klinische inventarisatie van implantologie bij Sjögrenpatiënten in Nederland. NUTS OHRA, granted € 150.000,- (2013, December 01 - 2016, December 01). Jager, D.H.J. & Forouzanfar, T. Klinische inventarisatie van implantologie bij Sjögrenpatiënten in Nederland. BioHorizons inc., granted € 118.000,- (2013, December 01 - 2016, December 01). Krom, B.P. Effect of quorum sensing inhibitors on biofilm formation in an ex vivo burn wound model. The National Institute for Biotechnology in the Negev Ltd. Be'er-Sheva, Israel, granted 2650 euro: (2015, January 01 – 2016, December 31). Krom, B.P., Brandt, B.W. & Exterkate, R.A.M. Plaque on white spots is different compared to plaque on dental enamel. GlaxoSmithKline, granted 15.000 euro: (2015, January 01 – 2016, December 31). Krom, B.P. & Hoogenkamp, M.A. (2016). Prontosan® for removal of biofilm-related infections in wounds. BBraun, granted €15.000: (2016, May – December). Krom, B.P., Exterkate, R.A.M. & de Wit W.E.A.J. Quorum Sensing compounds screening in the Amsterdam Active Attachment biofilm model. Commissioned Research Philips Group Innovation/Research, granted €20.000: (2016, May – October). Loos, B.G. & Teeuw, W.J. The implementation of oral care ORADIA. Sunstar, granted €171.000,-: (2014, January 01 - 2017, January 01). Smeele, L.E. Quantification of treatment-induced growth disruption using 3D photography in children with orbital rhabdomyosarcoma. Stichting ODAS, granted €87.827: (2016, January 01 - 2017, January 01). Ten Cate, J.M., Crielaard, W., de Soet, J.J., van Loveren, C., van der Veen, M.H. & Volgenant, C.M.C. Seeing is believing. STW project; granted € 500.000: (2010, October 01 - 2016, October 01). Van der Heijden, G.J.M.G. ADVOCATE -Adding value to oral care. Horizon 2020 Research Program, PHC-23- 2014, European Union EU, granted 6M€: (2015, May 01 - 2019, June 01). Van Loveren, C & Exterkate, R.A.M. Zuurproductie van biofilms blootgesteld aan verschillende melk- gerelateerde produkten. Commissioned Research Alpro, granted €5.000 (October 2016).

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Van Loveren, C. Cariogenicity of soja-milks: PI, Funded by Sint-Denijs-Westrem Belgium, grant 10 K€ (2016 – 2017). Van Loveren, C. Effect of the amount of sugar on caries development (2016 – 2017): PI, Funded by World Sugar Research Organisation (WSRO), total investment 5.5 K€. Van Loveren, C., van Strijp, A.J.P., Kleverlaan, C.J. & Feilzer, A.J. Infiltrating micro-sealant for preventive treatment of early non-cavitated caries (PEARL). Eurostars project 224 k€ (2016-2019). Veerman, E.C.I. Novel strategies to enhance oral health. Top Institute Food and Nutrition, 1 AIO: (2012, January 01 - 2016, December 31). Veerman, E.C.I. & Bikker, F.J. Functional food mondspray met ovomucine-bevattende microdruppels ter bestrijding van het droge mond syndroom. TKI-Agrifood, 150 k€: (2015, January 01 - 2019, December 31). Veerman, E.C.I., Bikker, F.J. & Brand, H.S. Analysis of canine saliva. Mars Inc. Granted 25 K€ (2016, May 01 – 2016, October 10). Wang, T. TOPPER project: Treatment of periodontal disease, prosthodontics evaluated by oral radiology. PhD program during 4 years, financially supported by Grant China Scholarship Council (CSC), granted €57.600,00: (2016, September 01 - 2020, November 01). Wismeijer, D., Bruers, J.J.M. & Reijers, H. Data mining naar de kosten effectiviteit van implantaat gedragen overkappingsprotheses in bestanden van de zorgverzekeraars. NWO project. Granted €78.000, (2015, January 01- 2016, December 31). Zaura, E. & Brandt, B.W. Use of novel molecular techniques for improvement of abortion diagnostics in ruminants, granted €15.000. Collaborative Research with Institute of Veterinary Bacteriology, University of Bern, Bern, Switzerland. Principal investigators: dr. S. Rodriguez Campos, prof.dr. V. Perreten. (2014, January 01 – 2016, December 31). Zaura, E. The effect of Philips Sonicare AirFloss Ultra plus Listerine Cool Mint compared to dental floss on gingival bleeding, dental plaque and gingival abrasion in a healing of experimental gingivitis model. Commissioned research Philips Healthcare, granted €90.000 (total investment €300.000): (2015, January 01 - 2016, December 31). Zaura, E. Transversal skills in dentistry: content and language integrated learning approach. ERASMUS+ strategic partnership project AGREEMENT No – 2015-1-LV01-KA203-013401– P3, granted €12668: (2015, December 01 - 2017, November 30).

Indicators of Esteem

Scientific awards/honours Shemesh, H. (April 8, 2016). Louis Grossman Award. French Endodontic Society and the American Association of Endodontics. During the AAE annual session in San Francisco, USA. Van der Velden, U. (April 15, 2016). Distinguished Scientist Award, Dutch Society of Periodontology, Lustrumcongres. Hoorn, the Netherlands. Zemouri, C. (May 9-12, 2016). The International Union against Sexually Transmitted Infections (IUSTI): 17th IUSTI world congress Marrakesh; Marrakesh, Morocco.

Memberships editorial board Aartman, I.H.A: European Journal of Dental Education. Bloemena, E.: ISRN Gastroenterology. Bloemena, E.: Scandinavian Journal of Gastroenterology. Bloemena, E.: World Journal of Gastrointestinal Oncology. Boutsioukis, C.: Journal of Endodontics. Brand, H.S.: Nederlands Tijdschrift voor Tandheelkunde. Crielaard, W.: Critical Reviews in Microbiology. Gorter, R.C.: European Journal of Dental Education. Krom, B.P.: Odontology. Krom, B.P.: Critical Reviews in Microbiology. Krom, B.P.: Scientific Reports.

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Laheij, A.M.G.A.: ACTA Quality Practice, editor in chief. Ligtenberg, A.J.M.: Scientific Reports - Nature. Laine, M.L.: Current Oral Health Reports. Laine, M.L.: Finnish Dental Society Apollonia Loos, B.G.: Journal of Clinical Periodontology. Loos, B.G.: Journal of Dental Research Loos, B.G.: Oral Health and Preventive Dentistry. Özen, B.: Biomed Research International (SCI-Expanded), Special Issue Biomaterials for Dental Applications, Hindawi Publishing Group. Özen, B.: Makara Journal of Health Research (MJHR) (Emerging Sources Citation Index), International Advisory Editorial Board member Özen, B.: American Journal of Medical Sciences and Medicine, Science and Education Publishing Özen, B.: Journal of International Dental and Medical Research, Ectodermal Displasia Group Özen, B.: EC Dental Science, Ecronicon. Rosema, N.A.M.: International Journal of Dental Hygiene. Shemesh, H.: International Endodontic Journal. Shemesh, H.: Journal of Endodontics. Velden, U. van der: Journal of Clinical Periodontology. Veerman, E.C.I.: Odontology. Zaura, E.: Caries Research.

Organization of (inter)national scientific congresses and symposia Bikker, F.J. (May 18-20, 2016). Atlant Conference. Innate host defence and infections, from basic science to applications. Utrecht, the Netherlands. Bloemena, E. (November 17-18, 2016). Novemberdagen van de pathologie, Amersfoort. Brand, H.S. (April 7-8, 2016). 7th Meeting of the Association of Basic Science Teachers in Dentistry, Amsterdam. Crielaard, W. (March 9-11, 2016). Co-organizer. Oral Microbiology and Immunology Group Meeting: Gregynog, Wales, UK. Crielaard, W. & Loos, B.G. (September 20–23, 2016). Organizing committee. Symposium: The healthy oral ecosystem is resilient to common challenges, International Association of Dental Research (IADR)/Pan European Region (PER), Jerusalem, Israel. Shemesh, H. (2016, October 7-8). 2nd Scientific meeting of the European Society of Endodontology (ESE), Amsterdam. Zemouri, C. (May 9-12, 2016). The International Union against Sexually Transmitted Infections (IUSTI): 17th IUSTI world congress Marrakesh; Marrakesh Morocco.

Invited speakers at (inter)national scientific congresses or symposia Bloemena, E. (April 8-9, 2016). Pathology of sentinel node biopsy in the SENT trial. 7th Meeting on Sentinel Node Biopsy in head and neck cancer, Rome, Italy. Boutsioukis, C. (April 8, 2016). Advances in root canal irrigation. San Francisco, American Association of Endodontics. Boutsioukis, C. (May 8-11, 2016). Root canal irrigation: blending endodontics and fluid dynamics. European Opinion Leader Meeting, organized by Dentsply Sirona, Lucerne. Boutsioukis, C. (June 24, 2016). Fluid dynamics in endodontic irrigation. Study Club meeting of the Cercle Parisien d’Endodontologie Appliquée, France. Brand, H.S. (September 22, 2016). Effect of experimental gingivitis induction and erythritol on the salivary metabolome. International Association for Dental Research (IADR)/PER Congress 2016, Jerusalem, Israel (2016, September 20 – 23). Crielaard, W. (September 22, 2016). The normal oral microbiome and its resilience to experimental gingivitis. International Association for Dental Research (IADR)/PER Congress 2016, Jerusalem, Israel (2016, September 20 – 23).

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De Soet, J.J. (March 11, 2016). Transmission of multiresistant bacteria amongst dental students, OMIG meeting, Gregynog Hall, Wales. Duijster, D. & van der Heijden, G.J.M.G. (May 11-13, 2016). Towards establishing a harmonized set of core oral health outcome measures. Workshop. 7th International Conference Methodological Issues in Oral Health Research. Methodology of handling data from longitudinal studies. Bergen, Norway. Krom, B.P. (April 3, 2016). Fungal-Bacterial Interactions. Preconference workshop, Paris. Krom B.P. (September 12-15, 2016). Molecular and physiological regulation of medical and environmental microbial biofilms. Summer School, Leuven, Belgium. Laine, M.L. (May 16, 2016). Genetics in dentistry. Finnish Doctoral Program in Oral Sciences (FINDOS), Genetic susceptibility to a complex disease periodontitis and dental caries. Helsinki, Finland. Laine, M.L. (May 3, 2016). Biofilm formation and antibiotic applications in peri-implantitis. China-Europe Medical Postgraduate Academy, Dental Implantology, Amsterdam, the Netherlands. Liao, Y. (2016, 11 March). A single nucleotide change leads to enhanced fluoride resistance in Streptococcus mutans, OMIG meeting, Gregynog Hall, Wales. Ligtenberg, A.J.M. (April 7-8, 2016) Saliva diagnostics and education. ABSTD Meeting, Amsterdam. Loos, B.G. (November 25, 2016). Periodontitis and cardiovascular diseases – The NL-studies, Dutch Society of Periodontology (NVvP) Paro & Partners, Utrecht, the Netherlands. Loos, B.G. (October 11, 2016). Oral infections and inflammation affect the cardiovascular system and the hematocrit. Invited lecture at the program: Good Oral Health and (top)sports, a double achievement! Scientific meeting Foundation Education in the Sportsmedicine, Bilthoven, the Netherlands. Loos, B.G. (September 20-22, 2016). Normal host immune factors in the healthy oral cavity and resistance to perturbation. Symposium The healthy oral eco-system is resilient to common challenges, during the International Association of Dental Research (IADR)/Pan European Region (PER), Jerusalem, Israel. Loos, B.G. (August 24, 2016). Periodontitis and atherosclerotic cardiovascular disease. School of Dental Medicine, Hong Kong University, Hong Kong. Loos, B.G. (August 5-7, 2016). Periodontitis and atherosclerotic cardiovascular disease: epidemiology, genes and therapy. Taishan Scholar International Dental Symposium, Yantai, Shandong, China. Loos, B.G. P, (June 22-25, 2016). Periodontitis, cardiovascular disease and diabetes: a role for good oral health. Symposium during the 94th General Session & Exhibition of the International Association of Dental Research (IADR), Seoul, Korea. Loos, B.G. (June 11, 2016). Focus on gingivitis and periodontitis from public health to chair side. Scientific Symposium (Industry Sponsored [Philips]) during International Dental Expo Beijing, China. Loos, B.G. (May 20-22, 2016). Genetics and microbiology interactions in periodontal therapy. Greek Society for Periodontology, 12th Symposium of Periodontology, Athens, Greece. Loos, B.G. (April 16, 2016). Goede gezondheid loont. Dutch Society of Periodontology (NVvP), 80th Anniversary meeting, Hoorn, the Netherlands. Özen, B. (October 29-30, 2016). Endodontology. Keynote Speaker 10th International Dentistry Scientific Meeting (ISDM), Indonesia. Rosema, N.A.M. (June 22, 2016.) Tandenpoetsen anno 2016, wetenschapsdag, CTM-Groningen, the Netherlands. Shemesh, H. (January 27, 2016). Vertical root fractures and endodontic instrumentation. Endodontic Association of Brazil, Sao Paulo, Brazil. Shemesh, H. (April 8, 2016). Debate on root dentine cracks and fractures and their origin. San Francisco, American Association of Endodontics. Shemesh, H. (July 7, 2016). Outcome of root canal treatments as seen on cone beam computed tomography. Sao Paulo, Brazil. Brazilian Dental Association . Van der Heijden, G.J.M.G. (August 24–26, 2016). Qualitative content analysis for international comparison of data usage agreements. International Population Data Linkage conference, Swansea, Wales. Van der Waal, I. (September 16, 2016,). Leukoplakia; to treat or no tot treat. EAOM, Torino, Italy. Van der Velden, U. (April 15, 2016). Etiologie en diagnose van parodontitis. Lustrumcongres Nederlandse Vereniging voor Parodontologie (NVvP). Hoorn, the Netherlands. Van der Velden, U. (May 26, 2016). The etiology of periodontal diseases and subsequent treatment strategies. Paris, France, Paris Diderot Paris7 University. Van der Velden, U. (October 28, 2016) Etiology of periodontitis and consequences for treatment. Bandung, Indonesia, Indonesian Society of Periodontology. Van der Velden, U. (October 31, 2016) Aggressive and chronic periodontitis: etiology and consequences for treatment. Padjadjaran University, Bandung, Indonesia.

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Van der Zande, M.M., Gorter, R.C., Aartman, I.H.A, Bruers, J.J.M. & Wismeijer, D. (June 22-25, 2016). Dentists’ considerations about using digital technologies and their job resources. IADR Seoul, South-Korea. Zaura, E. (March 22 - 23, 2016). On the oral microbiome and Candida interaction. KNVM/NVMM Scientific Spring Meeting, Papendal, the Netherlands. Zaura, E. (April 23, 2016). Promises and pitfalls of new technology, ERGOB symposium Consensus and controversies in dental research, Geneva. Zaura, E. (June 22 - 25, 2016,). Microbiome analysis by 16S rRNA gene amplicon sequencing: pros and cons in research and diagnostics, IADR Cariology group symposium, Seoul, Korea.

Other (inter)national scientific functions Bolscher, J.G.M.: Advisory Board Chiang Mai University Journal of Natural Sciences, 2013- heden. Brand, H.S.: President-Elect Salivary Research Group, International Association of Dental Research (IADR). Crielaard, W.: Co-chair of the ILSI Functional Food Taskforce Oral and Systemic Health. Crielaard, W.: Board member Oral Microbiology and Immunology Group, British Society for Oral and and Dental Research. Crielaard, W.: Visiting professor Oral BioSciences, Hong Kong University, Hong Kong, China. Crielaard, W.: Visiting professor Oral Microbiology School of Stomatology, Sun Yat Sen University, Guangzhou, China. Crielaard, W.: Member of the Thesis Advisory Committee Preethi Prajod; Faculty of Dentistry, National University of Singapore. Deng, D.M.: Coordinator International Summer camp for ACTA students, Chengdu, Sichuan, China July 3-17. Deng, D.M.: Guest professor Oral Microbiology, School of Stomatology, Sun Yat Sen University, Guangzhou, China. Deng, D.M.: Chair of PhD defense committees West China College of Stomatology, Sichuan University, Chengdu, China. De Soet, J.J., Member working group to develop new guidelines for Infection Prevention in dentistry for the NMT Nederlandse Vereniging voor Medische Microbiologie. De Soet, J.J.: Treasurer Stichting Orale Biologie. Gorter, R.C.: Executive committee Association for Dental Education in Europe (ADEE), since 2013. Gorter, R.C.: Executive committee Platform for Better Oral Health in Europe. Krom, B.P.: Member of the Thesis Defense Committee Marian Van Kerckhoven, Laboratory of Microbiology, Parasitology and Hygiene, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Belgium. PhD defense: April 2017. Krom, B.P.: Member of the Thesis Advisory Committee Devon Allison, Baltimore, Department of Microbial Pathogenesis, Dental School, University of Maryland, USA. PhD defense: May 2017. Laheij, A.M.G.A.: Member working group to develop new guidelines for Infection Prevention in dentistry for the NMT - Nederlandse Vereniging voor Medische Microbiologie. September 2013-2015. Loos, B.G.: Member IADR Distinguished Scientist Award Committee (2016-2017). Loos, B.G.: Member Continental European Division (CED) of IADR Research Prizes and Travel Grant Awards Committee (2007-current). Loos, B.G.: Member Expert Group Oral and Systemic Health Resilience within the Functional Foods Task Force, International Life Sciences Institute (ILSI) Europe, Brussels, Belgium. (2015-current). Loos, B.G.: Member Organizing Committee, EFP EuroPerio9, 2018, Amsterdam, the Netherlands. Loos, B.G.: Member IADR Young Investigator Awards Committee (2014-2017).

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Loos, B.G.: Board member and Treasurer, Society for the Advancement of Natural Sciences, Medicine and Surgery, University of Amsterdam. the Netherlands. (2013-current). Loos, B.G.: Councillor to the Board of the CED (Continental European Division) of the International Association of Dental Research (IADR) and CED representative to the PER (Pan European Region) of the IADR. (2013- 2016). Loos, B.G.: Member committee annual Meridol Research Prize, German Society of Periodontology (DGP), Germany. (2005-current). Loos, B.G.: Project leader European Periodontal Genetics (EPG) taskforce; a multicenter research project Genetics of periodontitis, a collaboration of University of Kiel, Germany, University of Oslo, Norway and ACTA, the Netherlands. (2001-current). Shemesh, H.: Member Scientific committee of the Dutch Association of Endodontology (NVvE). Van der Veen, M.H.: Honorary lecturer University of Liverpool, UK. Van der Veen, M.H.: Invited expert and member of working group 3 of EFP-ORCA joined workshop The boundaries between caries and periodontal diseases. Van der Velden, U.: Board member Education Committee of the European Federation of Periodontology. Van der Velden, U.: Chair Lustrumcongres Nederlandse Vereniging voor Parodontologie (NVvP) 15 April 2016, Hoorn, the Netherlands. Van der Waal, S.V.: Member scientific committee Nederlandse Vereniging voor Endodontologie (NVvE). Van Loveren, C.: Member advisory board Sugar Bureau UK. Van Loveren, C.: Member advisory board Tooth Friendly Society. Van Loveren, C.: Voorzitter Adviescollege preventie Mond en Tandziekten Ivoren Kruis. Volgenant, C.M.C.: Member working group to develop new guidelines for Infection Prevention in dentistry for the NMT Nederlandse Vereniging voor Medische Microbiologie. Zaura, E.: Visiting professor Oral Microbiology and Preventive Dentistry, Faculty of Medicine, University of Latvia, Riga, Latvia. Zaura, E.: Invited expert and member of working group 1 of EFP-ORCA joined workshop The boundaries between caries and periodontal diseases. Zaura,E.: Elected member of CED-IADR board, since September 2016.

Supervisor of an external PhD student Bolscher, J.G.M. (February 23, 2016). Co-supervisor of external PhD student C. Anutrakunchai with thesis Starvation response, biofilm formation and drug tolerance in Burkholderia pseudomallei. Supervisor: prof.dr. S. Taweechaisupapong, Khon Kaen, Thailand.

Collaborations - Ben Gurion University of the Negev, Beer Sheva, Israel, dr. M. Meijler. - BENECOMO, Flemish Netherlands Geriatric Oral Research Group and Zorgaccent, Amersfoort, the Netherlands, dr. G.J. van der Putten. - Charite, Berlin: dr. Paul Zaslansky and dr. Sebastian Paris. Grant application. - Clinic for Carolinas Health Care System Charlotte, North Carolina, USA Professor Michael Brennan. - College of Dentistry, New York University, USA, Richard Niederman. - Common Wealth University, Virginia, prof.dr. H.A. Schenkein. - Center for Advanced Research in Public Health, Valencia, Spain, dr. Alex Mira. - Centre for Integrative Bioinformatics (IBIVU), VU Amsterdam, prof. J. Heringa, dr. S. Abeln. - Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, United Kingdom.

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- Department of Endodontics, School of Dentistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil. - Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden. - Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, the Netherlands. dr. W. van Wamel, dr. W. Kaman-van Zanten. - Department of Microbial Diseases, UCL Eastman Dental Institute, London, United Kingdom. - Department of Odontology, Facultad de Ciencias de la Salud, Universidad CEU-Cardenal Herrera, Valencia, Spain, prof.dr. S. Sauro. - Department of Oral Biology, Faculty of Odontology, Malmö University, Malmö, Sweden, dr. J. Neilands. - Department of Otorhinolaryngology, VUmc. - Department of Pathology, VUmc. - Department of Pedodontology, dr. B. Özen, Istanbul Kemerburgaz University, Istanbul, Turkey. - Department of Periodontology, Endodontology and Cariology, University of Basel, Basel, Switzerland. - Diseases and Immunology, Utrecht University, 3584 CL Utrecht, the Netherlands. prof.dr. H.P. Haagsman. - Division of Cariology and Endodontology, prof.dr. I. Krejci, University of Geneva, Switzerland. - Division of Molecular Host Defence, Faculty of Veterinary Medicine, Department of Infectious. - Department of Conservative Dentistry , University Medical Center Groningen, the Netherlands (dr. L.W.M. van der Sluis). - Department of Dentistry, Aarhus University- dr. Lisselotte Kirkevang. - Department of Endodontology, Dental School, Aristotle University of Thessaloniki, Greece (prof. T. Lambrianidis). - Department of Periodontics, School of Dentistry, University of Missouri-Kansas City, USA, Charles Cobb. - Division of Endodontics, Department of Dental Medicine, Karolinska Institutet, Sweden (dr. L.E. Chavez de Paz). - Erasmus Medisch Centrum, dr. M. van Zelm. - Faculty of Archaeology, Leiden University, drs. K.A. Ziesemer, prof.dr. Corinne Hofman. - Genetics and Genomic Medicine Programme, UCL Institute of Child Health, London, United Kingdom. - Health Science Research Center, Indiana University-Purdue University, Fort Wayne, IN, USA, Mark Putt. - Helperby Therapeutics Limited, London, United Kingdom. - Interleukin Genetics, USA: prof.dr. K. Kornman. - Kindertandheelkundepraktijk Bambodino, Rotterdam, the Netherlands, dr. D.L. Gambon. - Khon Kaen University, Thailand, Dept of Oral Diagnosis, prof.dr. S. Taweechaisupapong, dr. S. Kanthawong and dr. C. Anutrakunchai. - Mesoscale Chemical Systems, Faculty of Science and Technology, University of Twente, the Netherlands (dr. D. Fernandez Rivas). - MSB Group: S. Imangaliyev and E. Tsivtsivadse. - OLVG, afd. Verloskunde & Gynaecologie, dr. M. van Pampus. - Oral Diagnostic Sciences University of Adelaide, Adelaide, Australia, Professor Richard Logan. - Physics of Fluids group, Faculty of Science and Technology, University of Twente, the Netherlands (dr. B. Verhaagen, prof. M. Versluis). - Radboud University Medical Center prof.dr. W.H. van Palenstein Helderman and prof.dr. Nicole Blijlevens. - Research Group Microbiology and Systems Biology, TNO Earth, Life and Social Sciences, Zeist, the Netherlands. - School of Stomatology, Sun Yat Sen University, Guangzhou, China, prof. X. Wei. - Temple University Philadelphia, Kornberg Dental School, United States. - The Netherlands Organization for Applied Scientific Research (TNO), Zeist, the Netherlands. - The Swammerdam Institute for Life Sciences, UvA, Amsterdam, dr. Joost Teixeira de Matos. - Tigran, Malmö, Sweden, U. Lundgren. - TNO, Zeist, dr. E. Tsivtsivadze and prof.dr. B. Keijser, Preventive Dentistry, ACTA-TNO, Zeist. - UCLA, School of Dentistry, Los Angeles CA. Wong, D.T.W. - University of Amsterdam, Core facility Cellular Imaging / LCAM-AMC. J. Stap. - University of Maryland Dental School, Baltimore, USA, dr. M.A. Jabra-Rizk. - University of Nagasaki, Japan, dr. Y. Iijima. - University of Phayao, Thailand, School of Medical Science. dr. A. Puknun. - Uniklinikum Schleswig-Holstein-Campus, Kiel, Germany, Clinic for Conservative Dentistry and Periodontology, Christof Doerfer and Karim M. Fawzy El-Sayed.

44 Academic Centre for Dentistry Amsterdam

- Universiteit van Amsterdam, AMC, Dept. of Clinical Chemistry. - Universiteit van Groningen, Dept. of Periodontology. - University Federico II, Naples, Italy. Department of Periodontology, Andrea Blasi. - University of Bandung, Indonesia, Amaliya. - University of Bonn, Dept. of Periodontology, prof.dr. S. Jepsen. - University of Cagliari, Italy, prof. E. Cotti. - University of Cairo, Oral Medicine and Periodontology Department- Faculty of Dentistry- Egypt, Karim M. Fawzy El-Sayed. - University of Gothenburg Sweden Professor Inger von Bültzingslöwen. - University of Kiel, Germany, Dept. of Gastro‐Enterology, prof.dr. S. Schreiber. - University of Kiel, Germany, Institute for Clinical Molecular Biology, dr. A. Scheafer. - University of Kristianstad, Sweden, prof.dr. S. Renvert. - University of Madrid, Spain, prof.dr. M. Sanz. - University of Malaya, Malaysia, Faculty of Dentistry, dr. Rathna Devi Vaithilingam. - University of Milan, Italy, Unit of Periodontology, Giulio Rasperini. - University of Patras, Greece, prof.dr. T. Bountis. - University of Rome, Italy, prof. dr. Pilloni. - University of Toronto, Dept. of Endodontics dr. Anil Kishen. - University of Wageningen, the Netherlands, dr. S. Boesveldt. - VU University Medical Center, Amsterdam, the Netherlands. Department of Oral and Maxillofacial Surgery/Oral Pathology: J.A. Baart, T. Forouzanfar, D.J. Jager, K.H. Karagozoglu. - West China School of Stomatology, Sichuan University, China, prof. J. Li, dr. L. Cheng.

Current PhD projects Akveld NAE. Tailor-made transparency-intervention for dentists: using registry feedback to improve effectiveness of caries related oral healthcare. Supervisor: prof.dr. J.J.M. Bruers; co-supervisor: prof.dr. G.J.M.G. van der Heijden, start: 2015. Baâdoudi F. Horizon 2020 (EU) ADVOCATE field studies. Supervisor: prof.dr. G.J.M.G. van der Heijden, co- supervisor: dr. D. Duijster, start: 2015. Baaij A. Curricular changes in undergraduate dental education. Supervisor: prof.dr. J.F.M. Roeters; co- supervisor: dr. A.R. Özok, start: 2014. Beerens MW. Aspects in the prevention of caries in patients undergoing orthodontic treatment with multi- bracket fixed appliances. Supervisor: prof.dr. J.M. ten Cate; co-supervisor: dr.ir. M.H. van der Veen, start: 2009. Boink MA. Histatin peptides for treatment of chronic wounds. Supervisors: prof.dr. E.C.I. Veerman & prof.dr. S. Gibbs; co-supervisor: dr. J.G.M. Bolscher, start: November 2010. Broers DLM. Experienced-based dentistry in individuals with physical and/or mental limitations. Supervisor: prof.dr. A. de Jongh; co-supervisor: prof.dr. G.J.M.G. van der Heijden, start: 2012. Cao Y. Different osteoclasts and their response to cytokines. Supervisor: prof.dr. V. Everts, co-supervisor: dr.ir. T.J. de Vries, start 2014. Delatola C. Phenotyping and clustering of periodontitis patienst. Supervisor: prof.dr. B.G. Loos, co-supervisor: dr. M.L. Laine, start: December 2016. De Jong BG. Local and systemic antibody responses for maintaining gingival health. Supervisors: prof.dr. W. Crielaard & prof.dr. B.G. Loos; co-supervisor: dr. M.C. van Zelm, start: April 2012. De Jong-Lenters M. Gebitsgezondheid van kinderen in relatie tot het gezin. Supervisor: prof.dr. G.H.W. Verrips & prof.dr. C. van Loveren; co-supervisor: dr. A.A. Schuller, start: June 2012, end: 2016. De Roos CJAM. Treatment of children following a potential traumatic incident. Supervisors: prof.dr. A. de Jongh & prof.dr. P.M.G. Emmelkamp, start: 2008. De Vries MW. The association between artritis and oral tissues. Supervisors: prof.dr. F. Lobbezoo & prof.dr. D. van Schaardenburg; co-supervisors: prof.dr. B.G. Loos & prof.dr. W. Crielaard; daily supervision: dr. C.M. Visscher, 1st, start: 2015 (PhD-student stopped in June 2016, Kroese wil take over the position in March 2017; dr. C.M.C. Volgenant will join the team as daily supervisor). Dekker H. Peri-implantitis, implant loss and osteoradionecrosis in oral cancer patients. Supervisors: prof.dr. E.A.J.M. Schulten, prof.dr. C.M. ten Bruggenkate & prof.dr. E. Bloemena; co-supervisor: dr. N. Bravenboer, start: 2010.

45 Annual Research Report 2016

Donders HCM. The effects of periodontal therapy on systemic health of patients with cardiovascular disease. Supervisors: prof.dr. J. de Lange & prof.dr. B.G. Loos; co-supervisor: dr. A.W.J. van 't Hof, start: January 2011. Elkerbout TA. Oral hygiene. Supervisor: prof.dr. G.A. van der Weijden, co-supervisor: dr. D.E. Slot, start: May 2015. Esposito SA. Endodontic applications of 3D imaging techniques in diagnosis of periapical lesions. From ultrasound to MRI. Supervisor: prof.dr. P.R. Wesselink; co-supervisor: dr. H. Shemesh & prof. E. Cotti, start: 2015. Everaars B. De rol van mondgezondheid en mondzorg op de voorspelbaarheid van kwetsbaarheid bij thuiswonende ouderen. Supervisor: prof.dr. G.J.M.G. van der Heijden, co-supervisor: prof. J.J. de Wit. Start: 2016. Fernandez y Mostajo M. Novel methods for preventing and treating polymicrobial biofilm infections in the oral cavity. Supervisors: prof.dr. W. Crielaard, prof.dr. G.A. van der Weijden & prof.dr. W. Beertsen; co- supervisor: dr. E. Zaura, start: June 2011. Geurs N.C. Socket preservation after extraction for implant dentistry. Supervisors: prof.dr. B.G. Loos & prof.dr. U. van der Velden, start: 2010. Gunput STG. The effect of saliva on the complement system. Supervisor: prof.dr. E.C.I. Veerman; co- supervisor: dr. A.J.M. Ligtenberg, start: January 2012. Hansenova Manaskova S. Sortase as target for antimicrobial peptides. Supervisor: prof.dr. E.C.I. Veerman; co- supervisor: dr. F.J. Bikker, start: November 2010, end: 2016. Haverman TM. Oral mucositis. Supervisors: prof.dr. F.R Rozema & prof.dr. W. Crielaard; co-supervisors: dr. J.E. Raber-Durlacher & dr. A.M.G.A. Leheij. Start: January 2013. Helmers R. Hyperbaric oxygen therapy and micro vascularisation. Supervisor: prof.dr. J. de Lange; co- supervisor: dr. D.M.J. Milstein, start: September 2011. Hennequin-Hoenderdos NL. Piercings and abrasion. Supervisor: prof.dr. G.A. van der Weijden, co-supervisor: dr. D.E. Slot, start May 2015. Hertog D. Treatment of ameloblastomas. Supervisor: prof.dr. E.A.J.M. Schulten; co-supervisor: prof.dr. I. van der Waal, start: September 2009. Hol MLF. Skull growth in oncological treatments in childhood. Supervisors: prof.dr. L.E. Smeele & prof.dr. A.G Becking, start: January 2013. Hummel GI. Van meten naar verbeteren? Hoe uitkomstindicatoren de behandelaanpak van de tandarts en de cariësincidentie bij de jeugd beïnvloeden. Supervisors: prof. dr. G.J.M.G. van der Heijden & prof. dr. J.J.M. Bruers, start: 2015. Imangaliyev S. Novel strategies to promote oral health. Supervisor: prof.dr. W. Crielaard; co-supervisor: prof.dr.ir. B.J.F. Keijser, start: September 2012, end: 2016. Janus MM. Microbial interactions in oral biofilms. Supervisor: prof.dr. W. Crielaard; co-supervisor: dr. B.P. Krom, start: June 2012. Karagozoglu KH. Endoscopy of salivary gland diseases. Supervisor: prof.dr. T. Forouzanfar; co-supervisor: dr. J.G.A.M. de Visscher, start: 2016. Koopman JE. Ecological dynamics of oral microbial communities. Supervisors: prof.dr.ir. B.J.F. Keijser & prof.dr. W. Crielaard; co-supervisor: dr. E. Zaura, start: April 2010, end: 2016. Kosho MXF. Periodontitis as an early risk indicator for atherosclerotic cardiovascular disease and diabetes mellitus: a multicenter study (PACMEL). Supervisor: prof. dr. B.G. Loos, co-supervisor: drs. W.J. Teeuw, start: 2016. Kraaij S. Salivary stones. Supervisors: prof.dr E.C.I. Veerman & prof.dr. T. Forouzanfar; co-supervisor: dr. H.S. Brand, start: 2016. Liao Y. Fluoride resistance of Streptococcus mutans. Supervisors: prof.dr. C. van Loveren & prof.dr. W. Crielaard; co-supervisors: dr. B.W. Brandt & dr. D. Deng, start: 2014. Louropoulou A. Maintenance of peri-implant health, the evidence and guideline. Supervisor: prof.dr. G.A. van der Weijden, start: 2010. Matse JH. The diagnostic role of mucin expression in tissue and saliva in patients with salivary gland tumors. Supervisors: prof.dr. E. Bloemena & prof.dr. E.C.I. Veerman; co-supervisor: dr. J.G.M. Bolscher, start: September 2008. May A. Bioinformatic analysis for oral metagenomics. Supervisors: prof.dr. W. Crielaard & prof.dr. J. Heringa; co-supervisors: dr. B.W. Brandt & dr. S. Abeln, start: August 2012. Mevissen-Renckens EHM. EMDR as a treatment of individuals with intellectual disabilities. Supervisor: prof.dr. A. de Jongh; co-supervisor: prof.dr. R. Didden, start: 2010.

46 Academic Centre for Dentistry Amsterdam

Moghimi M. Head and neck infection. Supervisors: prof.dr. T. Forouzanfar & prof.dr. E.A.J.M. Schulten, start: 2011. Moinzadeh AT. Quality assessment of root canal obturation. Supervisor: prof.dr. P.R. Wesselink; co-supervisor: dr. H. Shemesh, start: 2012, end: 2016. Moonen CGJ. Identification of the cellular interactions that leads to alveolar bone destruction in periodontitis. Supervisor: prof.dr. B.G. Loos, co-supervisors: dr.ir. T.J. de Vries & Dr. E.A. Nicu. Start: 2016. Neelakantan P. Influence of irrigation solution on the root canal filling. Supervisor: prof.dr. P.R. Wesselink; co- supervisor: dr. H. Shemesh, start: 2012, end: 2016. Papantonopoulos GH. Mathematical modeling of periodontitis. Supervisor: prof.dr. B.G. Loos, start: 2012, end: 2016. Persoon IF. Molecular ecology and novel treatments in endodontic infections. Supervisor: prof.dr. W. Crielaard; co-supervisor: dr. A.R. Özok, start: 2010, end: 2016. Prodan A. Saliva and oral health. Supervisors: prof. dr. E.C.I. Veerman; co-supervisors: dr. H.S. Brand & prof.dr.ir. B.J.F. Keijser, start: September 2012. Rademacher WMH. Oral complications in oncological treatment. Supervisors: prof.dr. F.R. Rozema & prof.dr. J. de Lange; co-supervisor: dr. D.E. van Diermen. Start: August 2013. Raghav K. The use of virtual reality technology for the treatment of dental fears. Supervisor: prof.dr. A. de Jongh, start: 2013. Rijkschroeff P. The oral polymorphonuclear neutrophils. Supervisor: prof.dr. B.G. Loos, co-supervisor: dr. E.A. Nicu, start: January 2013. Roseboom HJ. Oral mucositis and graft versus host disease (GVHD) after stem cell transplant: the role of different host factors and oral pathogens. Supervisors: prof.dr. F.R. Rozema & prof.dr. W. Crielaard; co- supervisors: dr. D.M. Deng & dr. A.M.G.A. Laheij, start: 2015. Sabrina D. Oral Pathology. Supervisor: prof.dr. T. Forouzanfar; co-supervisor: dr. M. Helder, start: 2016. Sahar A. Oral cancer and oral pathology. Supervisors: prof.dr. T. Forouzanfar & prof.dr. E. Bloemena; co- supervisor: dr. J.G.A.M. de Visscher, start: 2016. Sälzer SA. Dentifrices and Oral Hygiene. Supervisors: prof.dr. G.A. van der Weijden & prof.dr. C.E. Doerfer, co- supervisor: dr. D.E. Slot, start: May 2015, end: 2016. Schreuder WH. Treatment options in central giant cell granuloma. Supervisor: prof.dr. J. de Lange; co- supervisors: dr. H. van den Berg & dr. J.A.M. Bramer, start: January 2010. Shang L. Host and microbe interaction. Supervisors: prof.dr. C. van Loveren & prof.dr. S. Gibbs; co-supervisors: dr. D.M. Deng & prof.dr. W. Crielaard, start: 2015. Sijbrandij T. Application of antimicrobial peptides as anti-warfare therapeutics. Supervisors: prof. dr. E.C.I. Veerman; co-supervisors: dr. F.J. Bikker & dr. A.J.M. Ligtenberg,start: March 2010. Sprangers SL. Osteoclasts and their precursors. Supervisor: prof.dr. V. Everts, co-supervisor: dr.ir. T.J. de Vries, start: 2014. Steenen SA. The effects of propranolol on fear of wisdom tooth removal: A randomized, placebo-controlled. Double-blind parallel design trail. Supervisors: prof. dr. A. de Jongh & prof. dr. J. de Lange, start: 2013. Tabeian H. Arthritis models for the Temporo Mandibular Joint. Supervisors: prof.dr. V. Everts & prof.dr. F. Lobbezoo; co-supervisors: dr. A.D. Bakker & dr.ir. T.J. de Vries, start: 2012. Tan CWX. Oral manifestations of inflammatory Bowel disease. Supervisor: prof.dr. T. Forouzanfar; co- supervisor: dr. H.S. Brand, start: September 2012. Teeuw WJ. Relationships between periodontitis an general health: focus on diabetes and cardiovascular disease. Supervisor: prof.dr. B.G. Loos, start: October 2010. Ten Harkel B. Multinucleated giant cells versus osteoclasts. Supervisor: prof.dr. V. Everts; co-supervisor: dr.ir. T.J. de Vries, start: December 2011. Valstar MH. Controversies in epidemiology, diagnosis and treatment of salivary gland tumors. Supervisors: prof.dr. L.E. Smeele & prof.dr. A.J.M. Balm, start: May 2013. Van der Kaaij NCW. Efficacy of fluoride rinse in the prevention of caries in patients undergoing orthodontic treatment with multi-bracket fixed appliances. Supervisor: prof.dr. J.M. ten Cate; co-supervisors: dr.ir. M.H. van der Veen & dr. E. Zaura, start: 2009. Van der Sluijs E. Mouthrinses and Bad Breath. Supervisor: prof.dr. G.A. van der Weijden, co-supervisor: dr. D.E. Slot, start: May 2015. Van der Wouden P. Agendering van onderzoek in de mondzorg: De kennisagenda mondgezondheid. Supervisor: prof.dr. G.J.M.G. van der Heijden; co-supervisor: dr. H. Shemesh, start: May 2015. Van der Zande MM. Digital dentistry in practice: On dentists’ interaction with technological transformation. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. R.C. Gorter, start: February 2012.

47 Annual Research Report 2016

Van Dijk IA. How histatins enhances wound closure: structural and cellular aspects. Supervisor: prof.dr. E.C.I. Veerman; co-supervisor: dr. J.G.M. Bolscher, start: February 2011. Van Dijk S. Functional consequences of oral tongue carcinoma. Supervisors: prof.dr. L.E. Smeele & prof.dr. A.J.M. Balm, start: january 2013. Van Houtem CMHH. ADRA2B polymorphism as a putative biomarker for the acquisition of anxiety based on inadequate storage of emotional memories. Supervisor: prof.dr. A. de Jongh; co-supervisor: dr. A.J. van Wijk, start: 2009, end: 2016. Van Vliet NI. The necessity of stabilization in the treatment of complex PTSD. Supervisors: prof.dr. A. de Jongh & prof.dr. A. van Minnen, start: 2015. Verhulst JLM. The implementation of oral care in diabetic patients. Supervisor: prof.dr. B.G. Loos, co- supervisor: dr. V.E. Gerdes, start: January 2015. Vogels MPJM. Supervisor: prof.dr. J. de Lange; co-supervisor: H. Shemesh, start: 2015. Volgenant CMC. Red fluorescence in dental plaque. Supervisor: prof.dr. J.M. ten Cate; co-supervisor: dr.ir. M.H. van der Veen, start: 2010, end: 2016. Zecha JAEM. Effect van lage intensiteit laser behandeling (LLLT) op bestralingsmucositis van het mondslijmvlies. Supervisors: prof.dr. L.E. Smeele & prof.dr. J. de Lange; co-supervisor: dr. J.E. Durlacher, start: January 2013. Zemouri C. Hoe kunnen we de transmissie van potentieel schadelijke micro-organismen binnen de tandheelkundige praktijk verminderen? Supervisor: prof.dr. W. Crielaard; co-supervisors: dr. J.J. de Soet & dr. A.M.G.A. Laheij, start: December 2015. Zhao S. Acquired microbial antibiotic resistance in oral microbiota. Supervisors: prof.dr. B.J.F. Keijser & prof.dr. W. Crielaard; co-supervisors: dr. D.M. Deng, start: September 2016. Zygogiannis K. Mandibular overdentures retained by immediately loaded mini dental implants: expanding the treatment options for the edentulous patient. Supervisor: prof.dr. D. Wismeyer; co-supervisors: dr. I.H.A. Aartman & dr. A. Tahmaseb Eghbali, start: 2012.

Societal impact Oral infections and oral cancer have a substantial impact on the society. Oral infectious diseases are the most frequent infections in the western society and have important consequences, both medically and economically. Head and neck squamous cell carcinomas (HNSCC) and specifically oral squamous cell carcinomas (OSCC) are the most prevalent forms of head and neck cancer. The general aim of the program is to understand the normal healthy oral cavity and to understand links with general health, to study oral innate immunity and susceptibility to caries and periodontal diseases, to study prevention and treatment options for the oral infectious and inflammatory processes and to study the epidemiology and pathegnesis of oral cancers, in particular in relation to good/poor oral health. In addition, attention is paid to social and psychological aspects of dental treatment, such as dental anxiety. Through education, a new generation of dentists and researchers in the Netherlands, Europe and the world are trained to implement a radical shift from mechanistically and (invasive) treatment oriented professionals to 21st century oral physicians focused on diagnosis and prevention of dental and of oral infections and maintenance of the quality of life. Over the last 5 years it has become increasingly clear that oral infections are having negative impact on cardiovascular health, diabetic status and quality of life. The researchers in this theme focus on this aspect. The members of our priority area have had a relative large number of invitations to give lectures at dental congresses, and to educate the dental profession on fundamental understanding of oral health. Moreover, we experienced increased interest from newspapers, magazines and radio programs on the above subjects, in which we participated. The link oral health - general health is actively communicated by the researchers. Important for the dental profession and the general public, is the substantial number of published and accessible systematic reviews (and meta-analyses) on the various modes of prevention and oral hygiene measures. These contribute to clinical protocols for the dental profession and form the basis for evidence based dentistry. Ongoing clinical research on oral and head/neck cancer contributes to improved prevention, diagnosis and treatment of relevant patient groups. New plans are developed to bring together knowledge on oral microbiomes and salivary innate immune peptides with oral cancer diagnosis and pathophysiology. The program has strong links with all players in the oral care industry; this not only results in contract research, but also in industrial co-funding of grants (STW) and has led to participation of ACTA in the Top Institute Food

48 Academic Centre for Dentistry Amsterdam and Nutrition (TIFN), where the theme Oral Health has been initiated. In this theme, world players in the oral care industry, the chewing gum industry, flavour industry, food industry and (oral) care appliances industry collaborate with the University of Wageningen, TNO and ACTA. The societal impact of the research is evident from the impact on patient care and public dental health, and from collaborations with the industry, as is shown by for instance the grants obtained and the external reports. The societal impact of the clinical research contributes to improved prevention, diagnosis and treatment of relevant patient groups. The societal impact is evident from the items listed below. The societal impact of the clinical research on oral and maxillofacial surgery is focussed on the influence on patient care, both within the department and externally. Research contributes to improved treatment of relevant patient groups.

I. Societal relevance for the dental professional in the Netherlands

Courses organized for Dutch dental and medical professionals Brand H.S. (June 3, 2016). Acute Medische Situaties in de Tandartspraktijk. PAOT-cursus, ACTA, Amsterdam. Brand H.S. (September 9, 2016). Acute Medical Situations in the dental office. Post graduate school, ACTA, Amsterdam. Gorter, R.C. (April 2 - 23 & September 3 – 24, 2016). Herregistratie BIG voor tandartsen: ACTA, Amsterdam. Van der Waal, I. (February 5, 2016). Mondpathologie. Een nascholingscursus voor KNO-artsen en dermatologen. Amsterdam. Van der Waal, I. (2016). Leukoplakie en daarop lijkende afwijkingen. E-learning nascholingscursus voor tandartsen. Accredidact, Prelum, Houten. Van der Waal, I. (2016). Mondafwijkingen bij ouderen (herziening en samenvoeging van eerder samengesteld materiaal). E-learningcurus. E-Wise, Utrecht.

Lectures given during courses for Dutch dental and medical professionals Bizzarro, S. (April 8, 2016). Course for general practitioners: parodontale chirurgie in de algemene praktijk. Acta Dental Education, Acta, Amsterdam, the Netherlands,. Brand, H.S. (March 12, 2016). De tandarts een eeuw in the picture. ANT Congres, Amsterdam. Brand, H.S. (December 10, 2016).The do’s and don’ts in acute medische situaties. Terug naar de schoolbanken. Assistentendag, Amersfoort. De Soet, J.J. (April 13 & 19, 2016). IQual/Preventietour KNMT: Herziene richtlijn infectiepreventie, wat is echt nieuw? De Vries, T.J. (October 11, 2016). Celbiologie met tandgeassocieerde cellen van FOP patiënten. Special evening on FOP and dentistry. Centrum Bijzondere Tandheelkunde Rijnmond, the Netherlands. Laheij, A.M.G.A. (December 12, 2016). Avondseminar ACTA-DE: Nut en noodzaak van hygiëne en infectiepreventie. Laheij, A.M.G.A. (November 18, 2016). Assistenten symposium ACTA-DE: workshop infectiepreventie. Laheij, A.M.G.A. (October 11, 2016). Avondseminar TTL Smithuis Hengelo: Implementatie van de nieuwe richtlijn Infectie Preventie Richtlijnen met de focus op de waterkwaliteit van dentale units. Laheij, A.M.G.A. (June 24, 2016). Jaarcongres KNMT: Richtlijn infectiepreventie voor assistenten. Laheij, A.M.G.A. (April 18 & 20, 2016). IQual/Preventietour KNMT: Herziene richtlijn infectiepreventie, wat is echt nieuw? Laheij, A.M.G.A. (March 12, 2016). ANT Dental studie update congres 2016: Voorkomen van kruisbesmetting door het juist indelen en reinigen/desinfecteren van praktijkruimtes. Laheij, A.M.G.A. (February 15, 2016). Avondseminar Oisterwijk: Nut en noodzaak van hygiene en infectiepreventie. Laine, M.L. (November 18, 2016). ADE dagcursus, Peri-implantitis: diagnostiek en behandeling, Zuid Limburgse Tandartsen Vereniging, Maastricht, the Netherlands. Laine, M.L. (June 26, 2016). Post HBO Mondhygiene, dagcursus Halitose, ACTA Amsterdam, the Netherlands. Laine, M.L. (April 20, 2016). Verwijzersavond Periodontology, Patiënt op leeftijd, ACTA Amsterdam, the Netherlands. Laine, M.L. (April 8, 2016). ADE QP voor Mondhygiënisten, Implantaten: Diagnostiek en uitvoering, Microbiologie van parodontale en peri-implantaire ontstekingen, ACTA Amsterdam, the Netherlands.

49 Annual Research Report 2016

Laine, M.L. (March 11, 2016). Preventie, ACTA QP, Mondgezondheid bij de ouder wordende patiënt, Utrecht, the Netherlands, Laine, M.L. (February 19, 2016). Organisatie van Nederlandse Tandprothetici (ONT), Nazorg bij implantaten, Microbiologie van parodontale en peri-implantaire ontstekingen, Amsterdam, the Netherlands. Laine, M.L. (January 15, 2016). KNMT Gelderland, Nazorg bij implantaten, Microbiologie van parodontitis en peri- implantitis. Duiven, the Netherlands. Loos, B.G. (March 11, 2016). Preventie van peri-implantitis, ACTA-QP MH 4, Nascholingscongres Preventie, Utrecht, the Netherlands. Loos, B.G. (April 9, 2016). De link tussen parodontale ontstekingen, diabetes en hart, ACTA-QP THK 4, Nascholingscongres Tandheelkunde over grenzen, Utrecht, the Netherlands. Loos, B.G. (April 23 & September 10, 2016). Parodontologie ACTA BIG re-registration course, Amsterdam, the Netherlands. Loos, B.G. (August 31, 2016). Van DPSI naar diagnose – het paroprotocol. ACTA Summerschool. Rosema, N.A.M. (November 4, 2016). Dagvoorzitter, Congres, NVAMK Uit de hoge hoed, Stadion Galgenwaard Utrecht, the Netherlands. Schoenmaker, A.M. (November 26, 2016). Het gebruik van tandgeassocieerde cellen in FOP onderzoek. Patients day fibrodysplasia ossificans progressiva society. Haarlem, the Netherlands. Schoenmaker, A.M. (October 11, 2016). Activine A, de nieuwe target in het FOP onderzoek. Special evening on FOP and dentistry. Centrum Bijzondere Tandheelkunde Rijnmond, the Netherland. Schreuder W.H. (2016). In de wereld van 3D reconstructies. Reünistendag Antonie van Leeuwenhoek. Schreuder W.H. (2016). Orale slijmvliesafwijkingen in de Tandheelkundige praktijk – Een stapsgewijze benadering van diagnostiek tot verwijzing. KNMT/AMC/AVL nascholingsavond. Schreuder W.H. (2016). Hoofdhalskanker anno 2016. KNMT/AMC/AVL nascholingsavond. Schreuder W.H. (2016). In de 3D wereld van de reconstructieve hoofdhalschirurgie. KNMT/AMC/AVL nascholingsavond. Teeuw, W.J. (November 24, 2016). The medical compromised patient. Seminar NVM, Breukelen, the Netherlands. Teeuw, W.J. (November 16, 2016). Oral health and chronic diseases. POH-dag, Alkmaar, the Netherland. Teeuw, W.J. (September 16, 2016). Does periodontal treatment really contribute to metabolic health? 25th- aniversary of the MSc-program Periodontology ACTA, Amsterdam, the Netherlands. Teeuw, W.J. (April 15-16, 2016). Old age has its infirmities. Lustrum congress NVvP, Hoorn, the Netherlands. Van der Waal, I. (November 5, 2016). Mondpathologie; een overzicht voor de algemeen-practicus. Edudentaal, Amsterdam. Van der Waal, I. (November 24, 2016). Mondklachten bij ouderen; wat te doen? VerenSO, najaarscongres Kiezen voor delen, Den Bosch. Van der Waal, S.V. (December 9, 2016). ACTA Dental Education Endodontische leergang, Amsterdam. Van Strijp, A.J.P. (January 4, 2016). Cariësmanagement: Een update Stafdag ACTA. Van Strijp, A.J.P. (April 16, 2016). Modern cariës management. Een update. Moderator dag 3 BIG herregistratie cursus. Van Strijp, A.J.P. (May 28, 2016). 1. Cariësmanagement: Gewoon gaaf. 2. Cariësrisicoschatting. Moderator and lectures ACTA-QP Mondhygiëne. Van Strijp, A.J.P. (September 16, 2016). Modern cariësmanagement. Een update. Moderator dag 2. BIG herregistratie cursus. Van Strijp, A.J.P. (November 25, 2016). De wetenschap achter de praktijk. NVM Educatie Mondhygiënisten. Mondzorg voor de jeugd: Kiezen voor kinderen. Volgenant, C.M.C. (November 18, 2016). Assistenten symposium ACTA-DE: workshop infectiepreventie. Volgenant, C.M.C. (April 11 & 14, 2016). IQual/Preventietour KNMT: Herziene richtlijn infectiepreventie, wat is echt nieuw? Arnhem en Lijnden. Zaura, E. (September 29, 2016). Towards understanding oral health. PAOT Klinische Avond, Akersloot.

Organization of congresses and symposia for professionals in the Netherlands Crielaard, W. & Loos B.G. (June 15, 2016). Symposium Antibiotica in de tandheelkunde, Amersfoort.

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Invited speakers at professional congresses or symposia in the Netherlands Bruers, J.J.M. (April 22, 2016). Een klacht! Wat doet dat met de tandarts? Lezing Actualiteitencursus: Recht en Onrecht in de Tandartspraktijk, Utrecht. Crielaard, W. (June 3, 2016). Van Aanvallen naar Verdedigen in de Orale Microbiologie. VIT Event 2016 De Aftrap, Implantologie is Topsport, Maastricht. Crielaard, W. (June 15, 2016). De effecten van antibiotica op het gezonde menselijk microbioom. Symposium Antibiotica in de tandheelkunde, Amersfoort. Crielaard, W. (November 30, 2016). Antibiotica, het menselijk microbioom & de parodontitis patiënt. Avondsymposium Antibioticagebruik & Nazorg implantologie in de algemene tandartspraktijk, Rotterdam. Gorter, R.C. (April 8, 2016). Uiterlijke schijn? Hoe belangrijk is het er mooi uit te zien? Nederlandsch Tandheelkundig Genootschap, Amsterdam. Gorter, R.C. (June 24, 2016). Een klacht, dat hakt er in! Koninklijke Nederlandse Maatschappij tot bevordering der Tandheelkunde, Jaarcongres, Maarssen. Gorter, R.C. (December 16, 2016). Burnout: risico’s, rode vlaggen en oplossingen. Lemion, Utrecht. Van der Heijden, G.J.M.G. (January 29, 2016) Mondzorg op een tweesprong. Onder Professoren X. Apeldoorn. Van der Waal, S.V. (June 15, 2016). Antibiotica in de tandheelkunde. ACTA Dental Education Symposium, Amersfoort. Van der Waal, S.V. (November 25, 2016). Nederlandse Vereniging voor Endodontologie/Tandartsen- endodontologen Nederland, Studiedag, Amsterdam. Zaura, E. (June 15, 2016) Antibiotica tijdens parodontitis – vaak weinig toegevoegde waarde. Symposium Antibiotica in de Tandheelkunde, Amersfoort.

Professional functions in the Netherlands Bloemena, E.: Voorzitter Wetenschappelijke Raad PALGA. Bloemena, E.: Bestuurslid Nederlandse Vereniging Voor Pathologie. Bloemena, E.: Voorzitter Cie Bij- en Nascholing NVVP. Bloemena, E.: Lid Richtlijn cie Hoofd-hals tumoren. Brand, H.S.: Lid ondernemingsraad ACTA. Danser, M.M.: Chair Nederlandse Vereniging voor Parodontologie (NVvP). De Soet, J.J.: Lid KNMT commissie Richtlijn infectiepreventie voor mondzorgpraktijken, KNMT Nieuwegein. Eijkman, M.A.J.: Chair Onder Professoren X, dr. G.J. van Hoytema Stichting, Apeldoorn, January 29, 2016. Eijkman, M.A.J.: Chair Themadag 1, Lifestyle en Mondgezondheid. QP Tandheelkunde, Utrecht, November 5, 2016. Jager, D.H.J.: Lid bestuur Nederlandse Vereniging voor Gnathologie en Prothetische Tandheelkunde (NVGPT). Laheij, A.M.G.A.: Lid KNMT commissie Richtlijn infectiepreventie voor mondzorgpraktijken, KNMT Nieuwegein. Laheij, A.M.G.A.: Lid KNMT Commissie OnderzoeksBegeleiding, KNMT, Nieuwegein. Laheij, A.M.G.A.: Lid Raad van Advies van de Nederlandse Wetenschappelijke Vereniging van Tandartsen (sinds september 2016). Laine, M.L.: Member Doctoral Education Committee ACTA (DECA). Laine, M.L.: Member Benoemingscommissie leerstoel Parodontologie, in het bijzonder de preventie en therapie van parodontale aandoeningen, dr. G.A. van der Weijden, section Periodontology, ACTA. Laine, M.L.: Member Structure committee of section Periodontology, ACTA. Laine, M.L.: Member Decentralized selection of dental students committee, ACTA. Özok, A.R.: Lid ACTA Ethische Toetsing Commissie (ETC). Schreuder, W.H.: Lid PAOK commissie NVMKA. Smeele, L.E.: Voorzitter auditcommissie Nederlandse Werkgroep Hoofd HalsTumoren. Smeele, L.E.: Lid Commissie Oncologie, Nederlandse Vereniging voor Mondziekten, Kaak- en Aangezichtschirurgie. Smeele, L.E.: Voorzitter DNHA (Dutch Head and Neck Audit).

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Van Loveren, C.: Chair Themadag 1, Lifestyle en Mondgezondheid. QP Tandheelkunde, Utrecht, November 5, 2016. Volgenant, C.M.C.: Lid KNMT commissie Richtlijn infectiepreventie voor mondzorgpraktijken, KNMT Nieuwegein.

II. Societal relevance for the dental professional internationally

Professional functions internationally Brand, H.S.: Co-opted member Association of Basic Science Teachers in Dentistry.

Invited speakers at international professional congresses or symposia Volgenant, C.M.C. (October 22, 2016). What is oral health? Colgate Talks (online conference), Basel (CH).

III. Contacts with the general public

Interactions with the press and the general public Boink M.A. (January 1, 2016). Onder de loep! Mireille Boink Interview Nederlands Tijdschrift voor Tandheelkunde 123 (2): 70. http://www.ntvt.nl/nieuws/onder-de-loep-m-boink Brand, H.S. (March 19, 2016). Speeksel, een unieke vloeistof. Regionale bijeenkomst Nederlandse Vereniging van Sjögren Patiënten. Leiden. Crielaard, W. (September 24, 2016). Poetsen we onze tanden te vaak? Interview met Jop de Vrieze, publicatie Volkskrant. De Jongh, A. (January 1, 2016). Vraag advies. Expert in Psychologie Magazine. https://www.psychologiemagazine.nl/redacteur/ad-de-jongh/# De Jongh, A. (February 2, 2016). PYTREC Interview Koerdische National TV omroep. YouTube, Television. https://www.youtube.com/watch?v=bH4nGqCPbDs De Jongh, A. (February 6, 2016). Niet praten maar kijken. Helpt EMDR nu zelfs tegen liefdesverdriet? Psychologie Magazine pp. 46-49 http://www.emdr.nl/niet-praten-maar-kijken/ De Jongh, A. (March 11, 2016). Vrees voor de tandarts. Interview Lokale Omroep Amstelveen RTVA. https://www.youtube.com/watch?v=BWzZWltl4mY De Jongh, A. (May 1, 2016). Getraumatiseerd na een oorlogsmissie. Altijd bang voor sluipschutters. Visie programmablad EO. De Jongh, A. (May 5, 2016). Zij houden Nederland in leven. Programma over innovaties in de zorg. TV NPO 1, Evangelische Omroep. http://psycho-trauma.nl/emdr-behandeling-in-uitzending-zij-houden-nederland-in- leven/ De Jongh, A. (June 11/12, 2016). Gaatjes of niet? Patiënten willen apk voor hun gebit. Interview Algemeen Dagblad http://www.ad.nl/nieuws/gaatjes-of-niet-patienten-willen-apk-voor-hun-gebit~ada7cdaf/ De Jongh, A. (July 16, 2016). EMDR is een populaire therapie om trauma’s te verwerken. Interview Parool PS. http://www.emdr.nl/artikel-in-het-parool-emdr-ziet-er-eenvoudig-uit-maar-het-is-meer-dan-een-vinger- heen-en-weer-bewegen/ De Jongh, A. (June 27, 2016). Een behandeling van een fobie voor de tandheelkundige behandeling met behulp van EMDR. Programma Genante tanden. RTL-4 Television. http://psycho-trauma.nl/medewerkers/ad-de- jongh/ De Jongh, A. (September 17, 2016). Wegwapperen maar. Interview door Els Quaegebeur. Vrij Nederland, pag. 40-45. https://www.vn.nl/emdr-als-traumaverwerking-trauma-wegwapperen/ De Jongh, A. (October 16, 2016). Verwerkt in een ogenblik. Interview Libelle 42: 70-73. http://www.emdr.nl/wp-content/uploads/2016/10/interview-Ad-EMDR-Libelle-okt-16.pdf De Jongh, A. (October 19, 2016). Onder volle narcose naar de tandarts is populair, maar 'absoluut niet nodig'. Interview RTL Nieuws 19 October. http://www.rtlnieuws.nl/gezondheid/onder-volle-narcose-naar-de- tandarts-is-populair-maar-absoluut-niet-nodig De Jongh, A. (December 4, 2016). Hoe kom ik van mijn bloosangst af? Lezersvraag Psychologie Magazine. Tips van een angstexpert. https://www.psychologiemagazine.nl/advies/hoe-kom-bloosangst-af/

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De Jongh, A. (December 6, 2016). Trauma's verdwijnen met simpele oogbewegingen. Interview Algemeen Dagblad december pp. 5. http://www.emdr.nl/wp-content/uploads/2016/12/Traumas-verdwijnen-met- simpele-oogbewegingen- AD-dec.-2016.pdf De Jongh, A. (December 13, 2016). EMDR. Interview op Ensie, https://www.ensie.nl/ad-de-jongh/emdr De Jongh, A. & Steenen S. (February 1, 2016). Vergeetpil tegen tandartsangst. Interview AMC Magazine nr. 1. https://issuu.com/amcamsterdam/docs/amc_magazine_nr._1_februari_2016 De Lange, J. (January 1, 2016). De mondhygiënist weet de weg naar het ziekenhuis steeds beter te vinden. Interview Quality Practice Mondhygiëne 9 (1): 4-6. http://www.qualitypractice.nl/mondhygienisten/ tijdschrift/tijdschrift_artikel/t/de_mondhygienist_weet_de_weg_naar_het_ziekenhuis_steeds_beter_te_vi nden Duijster, D. (January 1, 2016). De promotie: de rol van het gezin bij de preventie van cariës. Gezond gebit? Family matters! Interview Tandartspraktijk 37 (2): 29-31. https://mijn.bsl.nl/gezond-gebit-family- matters/7820646 Eijkman, M.A.J. (August 28, 2016). Tanden. Documentaire toont verband tussen tanden en cultuur. Dentz http://dentzmagazine.nl/wp-content/uploads/2016/08/pag.-42-47_Documentaire-Teeth-Art.pdf Gorter, R.C. (May 1, 2016). Burn-out onder tandartsen. Herkennen is één ding, erkennen is twee. Interview Dentz 5: 16-21. Gorter, R.C. (September 1, 2016). Loting was zo slecht nog niet. Tandheelkunde-faculteiten moeten hun studenten zelf gaan selecteren. Interview Dentz 9: 34-39. http://www.annedoeleman.nl/wp- content/uploads/2016/09/pag.-34- Gunput, S.T.G. (January 1, 2016). Onder de loep! Interview Sabrina Gunput Nederlands Tijdschrift voor Tandheelkunde 123 (5): 238. http://www.ntvt.nl/nieuws/onder-de-loep-sabrina-gunput Jerković-Ćosić, K. (October 14, 2016). Mondzorg ouderen moet bij zorgprofessionals prioriteit krijgen. Interview Dentz 10: 14-19. http://dentzmagazine.nl/wp-content/uploads/2016/10/p14-19_Module- Mondzorg-Hogeschool-Utrecht.pdf Crielaard, W. (September 24, 2016). Poetsen we onze tanden te vaak? Interview met Jop de Vrieze, publicatie Volkskrant. Koopman J.E. (January 1, 2016). Onder de loep! Interview Jessica Koopman Nederlands Tijdschrift voor Tandheelkunde 123 (1): 11. http://www.ntvt.nl/nieuws/onder-de-loep-jessica-koopman Laheij, A.M.G.A. (January 1, 2016). Tandarts, psycholoog en hoofdredacteur. Interview Quality Practice 11 (4): 4-6. http://www.qualitypractice.nl/tandartsen/tijdschrift/editie/tandheelkunde_over_grenzen Laine, M.L. (June 27, 2016). Halitose. Gezond Verstand TV programma NPO1. http://www.tv- visie.be/inhoud/nederland/laatste-aflevering-van-gezond-verstand-op-npo-1_84385/ Ligtenberg, A.J.M. (August 1, 2016). Interview voor de Slowaakse televisie in het wetenschappelijke programma Spectrum Vedy. Loos, B.G. & Wittekoek, J. (January 1, 2016). Mondgezondheid en algemene gezondheid: de mond is geen geïsoleerd orgaan. Interview Quality Practice Mondhygiëne 8 (2): 4-6. http://www.qualitypractice.nl/mondhygienisten/tijdschrift/tijdschrift_artikel/t/interview_1 Rijkschroeff, P. (January 1, 2016). Onder de loep! Interview Patrick Rijkschroeff Nederlands Tijdschrift voor Tandheelkunde 123 (9): 398. http://www.ntvt.nl/nieuws/onder-de-loep-patrick-rijkschroeff Rosema, N.A.M. (June 30, 2016). Waterflossen goed alternatief voor reinigen tussen de tanden. Artikel Telegraaf, www.gezond-leven.nu. Rosema, N.A.M. (August 4, 2016). Stoppen met flossen. Artikel Elsevier, www.elsevier.nl. Rosema, N.A.M. (December 4, 2016). Wat is de definitie van een gezonde mond? Artikel Factaal. Rosema, N.A.M. (June 1, 2016). Interview Martijn Rosema. Artikel Stand-by. Shemesh H. & van der Sluis L.W.M. (January 1, 2016). Meerwaarde van nieuwe producten voor endodontologie vaak beperkt. Interview quality Practice Tandheelkunde 11 (3): 4-6. http://www.qualitypractice.nl/tandartsen/tijdschrift/tijdschrift_artikel/t/meerwaarde_van_nieuwe_produ cten_voor_endodontologie_vaak_beperkt Teeuw, W.J. (November 8, 2016). Ernstige parodontitis moet je interdisciplinair behandelen. Interview Nederlands Tandartsenblad 71 (18); 8. http://ntdigitaal.nl/content/%E2%80%9Cernstige-parodontitis- moet-je-interdisciplinair-behandelen%E2%80%9D-0 Teeuw, W.J. (June 1, 2016). Mondzorg en diabetes mellitus. Information brochure Dutch Society of Diabetes. https://www.knmt.nl/diabetes Van der Heijden, G.J.M.G. & Bruers, J.J.M. (November 22, 2016). Nieuwe ruimte voor sociale tandheelkunde. Interview in Nederlands Tandartsenblad 71 (19): 23-35 http://ntblad.nl/content/meegegroeid-met-de- tijdsgeest

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Van der Waal, I. (September 14, 2016). Mijn patiënten inspireerden me. Interview Isaäc van der Waal Nederlands Tandartsenblad 71 (14): 12-15. http://ntblad.nl/content/isa%C3%A4c-van-der-waal-mijn- pati%C3%ABnten-inspireerden-me Van der Waal, S.V. (January 1, 2016). De promotie: Wortelkanaaldesinfectie in beweging. Onderzoek leidt tot innovatie. Interview Tandartspraktijk 37 (1): 31-33. https://mijn.bsl.nl/wortelkanaaldesinfectie-in- beweging/7462118 Van Houtem, C.M.H.H. (November 10, 2016). Doodsbang voor de tandarts. Interview NRC Next. https://www.nrc.nl/nieuws/2016/11/10/doodsbang-voor-de-boor-5233884-a1531236 Van Houtem, C.M.H.H. (November 10, 2016). Trauma door tandarts. Interview Parool. http://adbank.dossiers.knipselkranten.nl/abonnee/trauma-door-tandarts Van Houtem, C.M.H.H. (November 15, 2016). Tandarts heeft tandartsfobie aan zichzelf te danken. Interview De Standaard. http://www.standaard.be/cnt/dmf20161114_02572152 Van Houtem, C.M.H.H. (November 9, 2016). Hora est. Interview Folia blz. 45. http://www.folia.nl/uploads/Folia%2009_1645_inter.pdf Van Loveren, C. & Eijkman, M.A.J. (January 15, 2016). De tandarts speelt een te beperkte rol in het lifestyledebat. Interview Quality Practice Tandheelkunde 11(1): 4-6. http://www.qualitypractice.nl/ tandartsen/tijdschrift/tijdschrift_artikel/t/de_tandarts_speelt_een_te_beperkte_rol_in_het_lifestyledebat Van Strijp A.J.P. & Bonifacio, C.C. (January 1, 2016). Dreigende witte vlekken in cariësmanagement. Interview Quality Practice Mondhygiëne 8 (3): 4-6. http://www.qualitypractice.nl/mondhygienisten/tijdschrift/ tijdschrift_artikel/t/dreigende_witte_vlekken_in_cariesmanagement

Impact of the research on the general public or professionals Patients referred to the cariology clinic by their dentist are seen and advised. Laheij, A.M.G.A., de Soet, J.J. & Volgenant, C.M.C. Richtlijn Infectiepreventie KNMT Leden KNMT commissie Richtlijn infectiepreventie voor mondzorgpraktijken en bijdrage KNMT-infectiepreventie-filmpjes (www.knmt.nl/infectiepreventie). Laheij, A.M.G.A., de Soet, J.J. & Volgenant, C.M.C. Project Mondgezondheid van jongeren met een licht verstandelijke beperking en sociale aanpassingsproblemen bij het Leger des Heils. (Volgenant, C.M.C & De Soet, J.J.). Driejarig project waarbij jaarlijks gerapporteerd wordt naar het Leger des Heils. Volgenant, C.M.C & de Soet, J.J. Project Mondgezondheid bij bewoner op Sal, Kaapverdië, met een sociale achterstand. Project in samenwerking met de lokale overheid om mondgezondheid in kaart te brengen.

54 Academic Centre for Dentistry Amsterdam

Oral Regenerative Medicine

Program Leaders

Prof.dr. D. Wismeijer Department of Oral Implantology and Prosthodontics ACTA Gustav Mahlerlaan 3004 1081 LA Amsterdam Tel: +31-20-5980297 E mail: [email protected]

Prof.dr. C.J. Kleverlaan Department of Dental Materials Sciences ACTA Gustav Mahlerlaan 3004 1081 LA Amsterdam Tel: +31-20-5980882 E mail: [email protected]

Full professors

A.G. Becking C.M. ten Bruggenkate V. Everts A.J. Feilzer T. Forouzanfar

S. Gibbs J. Klein-Nulend J. de Lange F. Lobbezoo F.J.M. Roeters

E.A.J.M. Schulten P.F. van der Stelt D.B. Tuinzing N. de Vries A. Zentner

Introduction The human masticatory system has several important functions that determine an individual’s general health and well-being, like biting, chewing, swallowing, talking, laughing, and yawning. Sometimes, patients are confronted with problems in performing these functions. This may have various causes. On the one hand, chemical and bacteriological factors may hamper a healthy functioning of the masticatory system by causing infection and inflammation. On the other hand, mechanical overloading as well as underloading or disuse of

55 Annual Research Report 2016 the constituent structures of the masticatory system (viz., teeth, bone, cartilage, muscles, and joints) may yield functional oromandibular impairments. Importantly, trauma or disease may result in damaged tissues which in turn result in functional oromandibular impairments. The research of ACTA’s research program “Oral Regenerative Medicine” (ORM) focuses on regenerating damaged oral tissue by means of guided tissue regeneration, stem cell therapy or tissue engineering techniques, taking into account the mechanical threats for the masticatory system and inflammatory reactions involved in tissue repair. Relevant clinical problems are used to guide the research aimed at developing novel solutions for these clinical problems. Groups that are involved in ORM-ACTA are Oral Kinesiology (OKI), Oral Implantology and Prosthodontics (IMP), Dental Materials Sciences (DMS), Oral Cell Biology and Functional Anatomy (OCB/FA), Oral Radiology (ORA), Orthodontics (ORT), and Oral and Maxillofacial Surgery (OMS), both of the Academic Medical Center (AMC) and of the VU University Medical Center (VUmc). The Interfaculty MOVE Research Institute Amsterdam has chosen “Regenerative Medicine” as one of its domains (i.e., a collaboration of researchers within the VU campus on a key topic). Likewise, ORM has been formulated as one of the two priority areas (“zwaartepunt”) of ACTA. As implied above, a healthy oral system is characterized not only by the absence of infection and/or inflammation of dental and periodontal tissues, but also by a healthy musculoskeletal system and oral mucosa. Musculoskeletal tissues (i.e., bone, cartilage, muscles, and joints) and mucosa (epithelium and underling connective tissue) can be damaged or even destroyed by, for example, mechanical overloading, disuse, disease or trauma. In case of tissue loss, the replacement or regeneration of degenerating/degenerated cells, tissues, or organs is needed to restore or establish normal function. ORM studies these processes both at a fundamental and translational level in multidisciplinary settings, in which dentistry/oral medicine closely collaborates with medical disciplines like orthopaedics, neurology and dermatology/ plastic surgery, both within and outside The Netherlands. The objective of the ORM research is to investigate degenerating oral tissues in order to develop novel therapeutic strategies to replace or regenerate these tissues, thereby restoring oral function and thus improving oral health-related quality of life. The ultimate goal of oral regenerative medicine is to regenerate parts of the masticatory system, e.g. teeth, jaw bone and/or mucosa. Since this dot on the horizon is far away, we now concentrate on: A. Regeneration of jaw bone and oral mucosa. B. Local tissue and systemic (immune) response of the host to implant materials and restoratives. C. Implementing new technologies in the repair and restoration of oral and maxillofacial structures. D. Gaining in-depth knowledge of non-infectious diseases of the masticatory system.

Research objectives

A. Regeneration of jaw bone and oral mucosa Stem cells and smart substrates Adipose tissue derived stem cells have been used to heal bone defects in human jaws. The application of these cells proved to result in an improved healing of the bone defects. In the coming period this will be further explored making use of different types of biological and non-biological substrates (see B ). After we successfully determined the safety and efficacy of adipose stem cells together with a bone substitute material for bone regeneration in a clinical phase 1 study, we will continue to use maxillary sinus floor elevation as a valid model to test bone tissue engineering approaches.

3D printing and biomimetic coating - CAD/CAM For the repair of bone defects autologous bone is considered as the gold standard. However, the harvesting and transplantation of autologous bone is often associated with morbidity and pain at the donor site. Using bone tissue engineering technology we have developed a biomimetic octocalcium phosphate seeded with BMP-2 that in animal studies has proven to be osteoinductive, biocompatible and biodegradable. By making use of 3D bioprinters and the biomimetic coating developed in this research program, scaffolds containing (stem) cells and proteins will be constructed that can be implanted. The biomimetic coating involves the use of different growth factors that modulate cell behaviour and activity. By combining these different modalities it will be possible to finely tune tissue formation at sites wished for.

Computer Aided Design/Computer Aided Manufacturing (CAD/CAM) of tooth replacement, crown and bridgework and guided implant placement devices used to insert both tooth root implants as well as implants used to substitute bone loss based on CBCT scans combined with planning and designing software are also

56 Academic Centre for Dentistry Amsterdam being developed in this research program. In a joint project with industry the technology used to 3D print composite, PMMA and ceramics in crown and bridgework is being refined and a clinical trial has been initiated. A project focussed on the milling / printing of full tooth implants has shown that we can print teeth in titanium and zirconium within the same dimensions as the tooth scanned with CBCT. This technology makes it possible to design and fabricate implants for the specific bone volume in the individual patient. In-vitro research is being carried out to analyse the behaviour of cells of the oral mucosa around these printed implant materials.

B. Tissue response of the host to implant materials and restoratives Tissue response of the host Tissue lost after trauma or surgical intervention should be replaced or, most preferably, regenerate. In this part of the programme regeneration is induced by making use of a wide variety of scaffold materials, different cell types (e.g. stem cells) and a variety of growth factors and cytokines. The collaboration between clinical and non-clinical scientists from different departments and backgrounds (dental material sciences, implantology, oral cell biology) ensures a multi-disciplinary approach. It becomes more and more clear that implant materials, long thought as being harmless, may evoke an immunological response. Since the use of implant materials increases tremendously; knowledge about the response of these materials is of crucial importance. Whereas in the majority of cases, implants remain inert in the host, in some cases adverse events are observed. Host responses can include bioreabsorption (breakdown) of the implant material resulting in leachables, entering the surrounding tissue and systemic circulation. The local tissue effects include an inflammatory response leading to adjacent mucosa and bone degradation, irritation to the surrounding tissues and/or sensitization of the host. Systemic effects are largely not investigated yet but do include allergic skin rash. It is of utmost importance to develop safe biomaterials and implants for oral regenerative medicine. Scientists with different background have joined forces in order to tackle these issues. Two approaches to this research line are investigated: 1) Safety assessment of dental implants. For this the Adverse Outcome Pathway (AOP) approach is used to investigate potential inflammatory responses in full compliance with the 3Rs. Toxicity, irritation and sensitization are the focus. Both organotypic in vitro tissue engineered oral mucosa and bone constructs are used as healthy and disease models with integrated immune cells (eg Langerhans Cells) as well as traditional cell cultures. 2) Improved diagnostic testing of adverse events attributed to dental materials. Currently the skin patch test is used to identify an allergic response of the individual to a dental implant. Due to differences in skin and oral immunity as well as cutaneous penetration, often false negatives are diagnosed. Improved patch testing methods, (eg use of microneedles and different salts) as well as in vitro lymphocyte proliferation and cytokine tests are being investigated a alternatives.

Biological response to loading The maintenance and survival of tissues like bone and cartilage largely depend on mechanical loading exerted upon these tissues. The different cell types that harbour these tissues are mechanosensitive and respond to mechanical loading. Also the stiffness of the substrate the cells live on, has profound effects on their metabolic activities. A combination of substrate stiffness and mechanical loading will make it possible to direct the cells in such a way that they generate the required tissues, such as bone and cartilage. Insight in the interaction between the implanted material either being of biological or non-biological origin and the surrounding tissues is of crucial importance for the understanding how the host will respond to the implanted material. Special attention is paid to the response of the tissue under conditions of mechanical loading or unloading.

Response of oral mucosa to injury Oral mucosa heals rapidly and is almost scar free in contrast to skin. With the aid of physiologically relevant tissue engineered oral mucosa and skin constructs, mechanisms of healing are compared in vitro. In particular, differences in proliferation, migration and differentiation of the epithelium and the deposition of extracellular matrix by (myo-)fibroblasts are investigated. Trafficking of immune cells involved in determining the quality of scar formation is the focus as well as the impact of the environment e.g. air versus saliva. In addition to saliva, the role of the oral microbiome (oral healthy and pathogenic biofilm) is investigated with regards to oral mucosa homeostasis and wound healing. Once normal healing mechanisms are established, the models can be used to investigate i) medical devices (implants) safety and soft tissue attachement and ii) the mode of action of novel therapeutic compounds in vitro.

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C. Gaining in depth knowledge of non-infectious diseases of the masticatory system. Pain, trauma and dysfunction Overloading of the constituent tissues of the masticatory system, notably cartilage, bone, muscle tissue, periodontal tissues, and hard dental tissues due to bruxism (i.e., tooth grinding and clenching) and adverse oral habits (e.g., nail biting and excessive gum chewing) may lead to pain and dysfunction of the chewing apparatus. In turn, such conditions may yield risks for the individual’s general health and cognitive abilities. A threat to the success of dental implants is peri-implant disease which is characterized by bone loss around the individual implants. The primary cause of peri-implant bone loss can be overloading, immunological response to the implant material. The secondary cause of this bone loss is infection. Within the framework of ORM, the causes, consequences, and management of pain, trauma and dysfunction of the masticatory system are studied in multiple international and multidisciplinary settings. The following items are studied: - diagnosis, epidemiology, pathophysiology, and management of bruxism, obstructive sleep apnea, and orofacial pain. - relationship between mastication and cognition in elderly institutionalized persons with different types of dementia - surgical treatment strategies for orthognatic defects - incidence and treatment of maxillofacial trauma - peri-implantitis

Results obtained A. Regeneration of jaw bone and oral mucosa Stem cells and smart substrates  Biomimetic calcium phosphate coating can be a carrier for bone morphogenetic protein (BMP). Additional studies were published in which the release was investigated of bone morphogenetic protein (BMP) incorporated into calcium phosphate as a carrier. This technology known as biomimetic coating has been the basis for research at ACTA during the last 8 years. It has been shown to be an effective bone substitute in critical size defects promoting osteogenesis and enhancing bone growth. A PhD study that was defended this year has shown the value of this material in the regeneration of critical sized bone defects. This study also showed that when hydroxypropyltrimthylammonium chloride chitosan was incorporated into the calcium phosphate coating, next to osteogenic properties it also showed antimicrobial properties conferring this material a promising application in infected bone defects.  Tissue-engineered constructs need to become quickly vascularized in order to ensure graft take. One way of achieving this is to incorporate endothelial cells (EC) into the construct. The adipose tissue stromal vascular fraction (adipose-SVF) might provide an alternative source for endothelial cells as adipose tissue can easily be obtained by liposuction. Therefore we extensively characterized endothelial cells from adipose tissue (adipose-EC) and compare them with endothelial cells from dermis (dermal-EC) with respect to purity, surface marker expression, proliferation, migration, cytokine secretion and sprouting. Similar characteristics of adipose-EC compared to their dermal-derived counterpart were found making them an excellent source for tissue engineering purposes, since they are readily available, and easily isolated and multiplied.  In patients undergoing maxillary sinus floor elevation (MSFE) for dental implant placement, bone substitutes are currently evaluated as alternatives for autologous bone. However, bone substitutes have only osteoconductive properties and lack osteoinductive potential. We performed the first-in-human study using freshly isolated, autologous adipose stem cell preparations (the stromal vascular fraction (SVF) of adipose tissue) applied in a one-step surgical procedure with calcium phosphate ceramics (CaP) to increase maxillary bone height for dental implantations. Ten patients received CaP plus SVF on one side, whereas bilaterally treated patients (6 of 10) received CaP only on the opposite side. This allowed intrapatient evaluation of the potential added value of SVF supplementation, assessed in biopsies obtained after 6 months. Feasibility, safety, and potential efficacy of SVF for bone regeneration were demonstrated, showing high potential for this novel concept.  Stability and antithrombotic functionality of endothelial cells on silicone hollow fibers (SiHFs) are critical in the development of biohybrid artificial lungs. We found that flow preconditioning of endothelial cells on collagen-immobilized SiHFs enhanced cell retention and antithrombotic function, which could significantly improve current biohybrid artifical lungs.

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 Biomimetic coatings to increase endothelialization of blood-contacting materials in biomedical devices are promising to improve the biocompatibility of these devices. Although a stable extracellular matrix protein coating on a biomaterial’s surface is a prerequisite for endothelial cell attachment, it also stimulates platelet adhesion. Therefore. antithrombic additives, such as nitric oxide donors, to a stable protein coating might lead to successful endothelialization of a material’s surface. Our data showed that sodium nitrite-collagen coating with 25-50 M sodium nitrite on silicone tubes increases the number of endothelial cells attached and inhibits platelet adhesion suggest that this coating is highly promising for use in blood-contacting parts of biomedical devices.  Biocompatibility of artificial lungs can be improved by endothelialization of hollow fibers. Bioavailability of growth-inducing and anti-thrombotic agents on the hollow fiber-blood interface inhibits thrombosis. We found that nanoliposomal anti-thrombotic sodium nitrite-nanoliposomal growth-inducing growth hormone-collagen conjugate coatings promote endothelialization of silicone hollow fibers in biohybrid artificial lungs.  For bone tissue engineering synthetic biphasic calcium phosphate (BCP) with a hydroxyapatite-ß-tricalcium phosphate (HA/ß-TCP) ratio of 60/40 (BCP60/40) is succesfully clinically applied, but the high percentage of HA may hamper efficient scaffold remodeling. With BCP with a lower (HA/ß-TCP) ratio (BCP20/80) is more desirable is still unclear. Vascular development is needed before osteogenesis can occur. We found that BCP20/80-based composites showed enhanced osteogenic and vasculogenic differentiation potential compared to BCP60/40-based composites in vitro, suggesting that BCP20/80-based composites might be more promising for in vivo bone augmentation than BCP60/40-based composites.

3D printing and biomimetic coating - CAD/CAM, dental implants  A study on the precision of intraoral scanners using different software packages and different clinical parameters used in operative dentistry showed that there are several clinical circumstances that influence the clinical outcome. We have also shown that the combination of STL files and DICOM files when creating a digital planning environment in software to create drill guides and FDP’s for patient treatment has limitations. We see that VOXEL size in the DICOM file as well as scattering of metallic objects in the mouth (fillings, FDP’s etc) make it difficult and in some cases even impossible to match these files. We are now looking into technologies to make this matching process more predictable. Two articles on this subject was published this years.  Additive manufacturing is the process of building objects layer by layer by joining materials base on digital 3-dimensional (3D) model data. When using this technology in printing FDP’s (crown and bridge work) for dental use it is important that the materials used to print and the machines themselves are calibrated to optimise the fit of the restorations. Apart from that, the build direction also plays a role. We have managed to optimise the build angle of 3D printed resin based dental restorations so that they now are ready for clinical use. This year we were the first clinic in the world to 3D print a crown on a dental implant and insert this into a patients mouth.  Dental implants are generic in shape and size. This means that the implants dictate the shape and size of the bone defect in which they are to be inserted. Often this means that the bone has to be augmented to allow the implant to fit. Using CAD and 3D printing technologies we are now able to design dental implants in any dimension and shape to fit the bone instead of augmenting the bone to fit the implant. Implants have been printed in ceramics and titanium, and analysed for the dimensional stability and congruence to the CAD files showing promising results.  The same technology has been used to fine tune the autotransplantation of teeth. STL files to be transplanted teeth have been drawn from DICOM data from CBCT scans. Replicas of these teeth have been printed together with drills and osteotomes in titanium. After extraction of the hopeless or irrational to treat tooth the alveolus is shaped by using the drills and the osteotome to create a neo alveolus. The to be transplanted teeth are then extracted and transplanted to the neo alveolus. Our research shows that the fit is immediate, the periodontium of the to be transplanted teeth is hardly distorted and the ingrowth of the natural tooth is more predictable.  The diameters of dental implants generally vary between 3.0 and 6.0 mm. We have carried out a study looking at dental implants with a diameter varying between 1.8 and 2.4 mm supporting overdentures in edentulous patients. We have shown that these implants show at least in the short term predictable results comparable to regular diameter implants.  Two solitary dental implants in the maxilla with dalla bona attachments is an treatment approach that has not yet been reported on in the literature. We have an RCT running in the department where we have

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reported on the 1 year follow-up results in an article. These are a little less positive than when using 4 interconnected implants.  The fatigue properties of the dental CAD-CAM materials zirconia and lithium disilicate with respect to their manufacturing procedures.

B. Tissue response of the host to implant materials and restoratives Tissue response of the host  The gold standard for the diagnosis of allergic hypersensitivity is skin testing. However, this has only been validated for epidermal antigen contact. For several metals, patch testing gives unreliable results. The current alternative to metal allergy patch-testing is the in vitro lymphocyte proliferation test (LTT) using tritiated thymidine (3H). This method is promising but requires handling of radioactive material and has a low predictive value. Therefore the aim of this ongoing research is to develop a radioactive free LTT by using carboxyfluorescein succinimidyl ester (CFSE) and to evaluate the influence of human pooled serum (HPS) versus autologous serum, on the sensitivity of the LTT to nickel (NiSO4) and titanium salts. Peripheral blood mononuclear cells derived from nickel and titanium allergic patients and healthy controls are being used in this clinical study.  We have studies the clinical consequences when changing the position of the implant-abutment interface where restoring dental implants with an abutment en FDP’s. A PhD thesis showed that if the implant abutment interface is at bone level more bone loss can be seen on the X-rays. We also learned that if the mucosal thickness surrounding bone level implants is 2 mm or more there is statistically significantly less crestal bone loss when compared to bone level implants placed in less than 2 mm of initial mucosa thickness. This has implications when indicating either bone level or tissue level implants in partially edentulous patients.  Novel immune competent gingiva and skin equivalent models (GE-LC; SE-LC) (reconstructed gingiva epithelium with integrated MUTZ-3 derived Langerhans Cells on a fibroblast populated lamina propria) were used to compare LC activation and migration from oral versus skin epithelium. Topical exposure to sub-toxic concentrations of contact sensitizers resulted in LC migration out of the epithelia. Neutralizing antibody to CXCL12 blocked allergen-induced LC migration in SE-LC but not in GE-LC. Also, gingival fibroblasts secreted very low amounts of CXCL12 compared to skin fibroblasts even when stimulated with rhTNFα or rhIL-1α.  In gingiva, upon allergen exposure, MUTZ-3 LC migrate in a CXCL12 independent manner from the epithelium-to-lamina propria in contrast to the CXCL12 dependent manner found in skin. In both gingiva and skin, LC within the lamina propria were found to be mature becoming CD1a- CD83+. These physiologically relevant in vitro models, which not only are human but which also resemble specific tissues, may aid in the identification of factors regulating immune stimulation which in turn will aid the development of therapeutic interventions for allergy and inflammation, anti-cancer vaccines as well as improving diagnostics for skin and oral allergy.  Two studies showed toxic and immunological responses of palladium and nickel which were investigated because of their potential adverse effects from dental implants.

Biological response to loading  Insulin-like growth factor-1 (IGF-1) is anabolic for muscle by enhancing the rate of mRNA translation via activation of AKT and subsequent activation of the mammalian target of rapamycin complex 1 (mTOR), thereby increasing cellular protein production. IGF-1 is also anabolic for bone, but whether the mTOR pathway plays a role in the rate of bone matrix protein production by osteoblasts is unknown. We have shown that IGF-1 and pulsating fluid flow activate mTOR, thereby stimulating the rate of mRNA translation in osteoblasts. The known anabolic effect of mechanical loading and IGF-1 on bone may thus be partly explained by mTOR-mediated enhanced protein synthesis in osteoblasts.  Bone remodeling can be disturbed in active rheumatoid arthritis (RA), possibly as a result of elevated levels of circulating inflammatory cytokines. Osteocyte-specific proteins and cytokines play a vital role in bone remodeling by orchestrating bone formation and/or bone resorption. We found that gene expression of human osteocyte-specific proteins and cytokines was affected by RA-serum, and exogenous recombinant cytokines treatment suggesting that osteocytes could provide a new target to prevent systemic inflammation-induced bone loss in RA.  Delayed fracture healing is frequently experienced in patients with systemic inflammation such as during rheumatoid arthritis (RA). The reasons for this are diverse, but could also be caused by inflammatory

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cytokines and/or growth factors in serum from patients with active disease. We found that sera from patients with active RA negatively affect differentiation of osteochondrogenic precursors, and as a consequence may contribute to delayed fracture healing in these patients.  During the initial stages of bone repair, proinflammatory cytokines are released within the injury site, quickly followed by a shift to anti-inflammatory cytokines. The effect of pro- and anti-inflammatory cytokines on osteogenic differentiation of mesenchymal stem cells is controversial. We found that all cytokines studied have both enhancing and reducing effects on osteogenic differentiation of human adipose stem cells (hASCs), even when applied for 72 h only. Some cytokines, specifically IL-6, may be suitable to induce osteogenic differentiation of mesenchymal stem cells as a strategy for enhancing bone repair.

 The metabolite 1,25-dihydroxyvitamin D (1,25(OH)2D) is synthesized from its precursor 25-hydroxyvitamin D (25(OH)D) by human osteoblasts leading to stimulation of osteoblast differentiation in an autocrine or paracrine way. Osteoblast differentiation is also stimulated by mechanical loading through activation of various responses in bone cells such as nitric oxide signaling. We found that 1,25(OH)2D3 and mechanical loading, both stimuli of the differentiation of osteoblasts, interact at the cellular level.

Response of oral mucosa to injury  Tissue engineered oral mucosa equivalents constructed from TERT immortalized cells (OME) (reconstructed epithelium on a fibroblast populated lamina propria) were used to investigate inflammatory responses during wound healing. After introduction of a full thickness wound, OME showed an immediate inflammatory response (IL-6, CCL2 and CXCL8) followed by complete re-epithelialization. Seven days after wounding, tissue integrity, metabolic activity and cytokine levels had returned to pre- wounded state. This organotypic model will provide a valuable tool to investigate oral mucosa biology and can also be used as an animal alternative for drug targeting, investigating soft tissue attachment to implants, microbial biofilm studies and testing new therapeutics. Oral wounds heal faster and with better scar quality than skin wounds. Deep skin wounds where adipose tissue is exposed, have a greater risk of forming hypertrophic scars. Differences in wound healing and final scar quality might be related to differences in mesenchymal stromal cells (MSC) and their ability to respond to intrinsic (autocrine) and extrinsic signals, such as human salivary histatin. It was found that, compared to skin derived MSC, gingiva MSC showed greater proliferation and migration capacity, and less matrix contraction in full thickness tissue equivalents, which may partly explain the superior oral wound healing. Epidermal keratinocytes were required for enhanced adipose MSC matrix contraction and alpha smooth muscle actin expression, and may therefore contribute to adverse scarring in deep cutaneous wounds. Histatin enhanced migration without influencing proliferation or matrix contraction in all three MSC, indicating that salivary peptides may have a beneficial effect on wound closure in general. Understanding the mechanisms responsible for the superior oral wound healing will aid us to develop advanced strategies for optimal skin regeneration, wound healing and scar formation.  Chronic ulcers represent a major health burden in our society. Protein based therapies fail in part due to proteolytic activity in the chronic wound bed. In this study, the stability of saliva derived histatins within the chronic wound environment was investigated. Chronic wound extracts were isolated from non-healing ulcers in this in vitro study. Incubation with chronic wound extracts resulted in serious breakdown of Hst1 and Hst2 (~50% in 8h) and to lesser extent cyclic Hst1 and the minimal active domain of Hst1 (~20% in 8h). However, an initial 8-hour pulse of histatins during a 96-hour study period was sufficient to stimulate fibroblast migration equally well as a continuous 96-hour exposure, indicating that, despite being susceptible to proteolytic breakdown, they may possibly be used as novel bioactive therapeutics, exerting their activity for up to four days after a single exposure.

Gaining in depth knowledge of non-infectious diseases of the masticatory system. Pain, trauma and dysfunction  In a series of studies, we have demonstrated that 3D reconstructions of Cone-beam CTs of the upper airway can be performed reliable. In addition, based on a systematic review of the literature, the smallest cross-sectional area of the upper airway was found to be the most important anatomical characteristic to explain the pathophysiology of obstructive sleep apnea (OSA). Finally, the discipline “Dental Sleep Medicine” was redefined as to include other sleep disorders that affect (or are affected by) dentistry apart from OSA.  A study amongst adolescents in Israel showed that both sleep bruxism and awake bruxism are prevalent conditions, equally in both genders.

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 An extensive tooth wear evaluation system (TWES) was introduced. Using part of that system, it was shown that tooth wear can be assessed reliably on dental casts as well as on intra-oral photographs. Finally, a population study demonstrated that tooth wear is a prevalent condition in The Netherlands, and that the condition has gotten increasingly severe over the past ten years.  Studies on orofacial pain in intellectually disabled or non-verbal individuals revealed that 1. pictograms are helpful to assess both pain intensity and pain quality in adults with Down Syndrome; 2. The MOBID orofacial pain scale is not useful (not reliable) for pain assessment in people with severe dementia; and 3. The OPS-NVI yields promising results for the assessment of orofacial pain during eating of elderly with dementia.  Using the 3Q-TMD, a large-scale population study on the prevalence of temporomandibular disorders (TMD) was published, showing increasing symptoms during adolescence, a peak in middle age, and a gradual decrease thereafter – the more so in women as compared to men. The validity of the 3Q-TMD was demonstrated against the international gold-standard system DC/TMD. For the latter system, recommendations were formulated for its future usage in research and in clinical settings. Finally, the experience of TMD pain was found to be strongly associated with depression. Using computer models, it was shown that jaw-muscle relaxation and laterotrusive movements are useful strategies to resolve open locks of the temporomandibular joint.

Academic personnel in 2016 Research staff ACTA – ORM Oral Regenerative Medicine (in full time equivalents) Position Name 2016 Funding Becking, prof.dr. A.G. 0,20 1 Bruggenkate, prof.dr. C.M. ten -- pm Everts, prof.dr. V. 0,10 3 Feilzer, prof.dr. A.J. 0,05 1 Forouzanfar, prof.dr. T. 0,15 1 Forouzanfar, prof.dr. T. 0,05 3 Gibbs, prof.dr. S. 0,35 1 Klein Nulend, prof.dr. J. 0,70 1 Lange, prof.dr. J. de 0,10 1 Lobbezoo, prof.dr. F. 0,30 1 Full professors Lobbezoo, prof.dr. F. 0,05 3 Ravesloot, prof.dr. J.H. -- pm Roeters, prof.dr. F.J.M. -- pm Schulten, prof.dr. E.A.J.M. 0,10 1 Stelt, prof.dr. P.F. van der -- pm Tuinzing, prof.dr. D.B. 0,10 1 Vries, prof.dr. N. de 0,20 3 Wismeijer, prof.dr. D. 0,15 1 Wismeijer, prof.dr. D. 0,10 2 Wismeijer, prof.dr. D. 0,15 3 Zentner, prof.dr. A. 0,10 1 Bakker, dr. A.D. 0,70 1 Bronckers, dr. A.L.J.J. -- pm Helder, dr. M.N. 0,40 1 Hoekema, dr. A. 0,30 3 Senior lecturers Kleverlaan, dr. C.J. 0,50 1 Kleverlaan, dr. C.J. 0,05 3 Koolstra, dr.ir. J.H. 0,60 1 Kuitert, dr. R.B. 0,20 1 Langenbach, dr. G.E.J. 0,30 1

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Position Name 2016 funding Liu, dr. Y. 0,50 1 Liu, dr. Y. 0,30 2 Liu, dr. Y. 0,05 3 Sanderink, dr. G.C.H. 0,05 1 Senior lecturers Tahmaseb, dr. A. 0,30 1 Tahmaseb, dr. A. 0,05 3 Visscher, dr. C.M. 0,30 1 Visscher, dr. C.M. 0,05 3 Baart, drs. J.A. 0,05 1 Berkhout, dr. W.E.R. 0,20 1 Bos, dr. A. 0,30 1 Dubois, drs. L. 0,10 1 Geraets, dr. W.G.M. 0,40 1 Goené, drs. R.J. -- pm Hassan, dr. B.A. 0,20 3 Jager, dr.ir. N. de 0,05 3 Jongsma, dr. L.A. 0,15 1 Other lecturers and tenured Kok, drs. P. de 0,20 1 research staff Koutris, dr. M. 0,35 1 Muris, dr. J. pm 1 Poorterman, dr. J.H.G. -- pm Prahl, dr. C. 0,05 1 Selms, dr. M.K.A. van 0,35 1 Slot dr. D.E. 0,05 1 Verheij, dr. J.G.C. 0,15 1 Warnsinck, C.J. 0,05 1 Wu, dr. G. 0,40 1 Wu, dr. G. 0,50 2 Total tenured staff 11,30 Aarab, dr. G. 0,40 1 Algera, dr. T.J. -- pm Al Kurwi A. pm guest Amiri Bavandour, M. pm guest Apperloo, drs. R.C. 0,20 1 Baar, drs. G.J.C., van pm guest Baravordeh, F. -- pm Bollen, K. -- pm Bontkes, dr. H.J. 0,40 1 Bosch, M. van den -- pm Bruggeman, dr. J. P. 0,20 2 Non tenured staff Campos, dds. F. -- 3 Cioccari Oliveira, dds. S. 0,80 3 Calixtre, L.B. pm guest Danser, dr. M. pm guest Damaskos, dr. S. pm guest Disse, drs. M.A. 0,05 1 Elyassi, MSc. Y. 0,20 3 Engels, E. pm guest Entezami Rad, drs. N. -- pm Farhanghi, R. pm guest Farré-Guasch, dr. E. 0,10 3

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Position Name 2016 funding Flügge, dds. T.V. 0,20 3 Fraga, dds. S. 0,20 3 Gilijamse, drs. M. 0,05 1 Gimenez, dds. B. 0,20 1 Göbel, drs. J.C. 0,20 1 Hattem, A.B. pm guest Helmer, L. pm guest Hermus, R.R. pm guest Hoogeveen, MSc. R.C. 0,10 1 Iskender, S.Y. pm guest Jager, dr. D.H.J. 0,20 1 Joosten, M.W. pm guest Kapagiannidou, drs. D. -- pm Knibbe, drs. W. 0,05 1 Kramer, dr. G.J.C. pm pm Kuijs, R.H. 0,05 1 Lin, dds. X. 0,75 3 Liu, dds. Y. 0,55 3 Loon, dr. J.J.W.A. van 0,10 1 Loon, dr. J.J.W.A. van 0,80 3 Meer, H.A. van der pm guest Meijer, drs. B.A. 0,05 3 Mendrik, dr. A.N. 0,05 2 Milbradt Dutra, dds. D.A. 0,10 3 Nijkamp, P.G. pm guest Non tenured staff Nolte, F.M. pm guest Oey, C. pm guest Oosterhuis, M. pm guest Padmos, J. pm guest Papagianni, C. 0,05 1 Parvaneh, drs. D. -- pm Pereira, dds. G. 0,40 3 Ramdat Missier, R.H. pm guest Ras, F. pm guest Reyes Sevilla, drs. M. 0,05 1 Rollman, dr. A. 0,05 1 Slot, dr. D.E. 0,05 1 Soffner, M. -- pm Steegmans, P. pm guest Story, drs. J.J.P. 0,05 1 Vahed, MSc. F. 0,75 3 Vehmeijer, drs. M.J.J.B. 0,05 1 Volgenant, dr. C.M.C. 0,05 1 Weijenberg, dr. R.A.F. 0,25 1 Wetselaar, drs. P. 0,20 1 Wezel, N. van -- pm Wolff, dr. J.E.H. 0,10 1 Wolff, dr. J.E.H. 0,40 3 Yonel, dr. N. 0,10 3 Zandieh Doulabi, dr.ing. B. 0,70 1 Zardo Trindade, dr. F. 0,50 3

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Position Name 2016 funding Abdel Aziz, dds. M.F.A. pm guest Alharbi, dds.N.M. 0,75 3 Anssari Moin, drs. D. 0,10 3 Asikainen, drs. P.J. pm guest Baggen, drs. J.H.M. pm guest Bastidas Coral, dds. A.P. 0,80 1 Beerens, drs. M.W. pm guest Betti, MSc. B.F. pm guest Bergh, dr. B., van den pm guest Bouwman, drs. W.F. pm guest Buskermolen, MSc. J.K. 0,75 1 Cao, MSc. Y. 0,75 3 Chalil, dds. S. pm guest Chen, dds. H. 0,75 3 Couturier, drs. E.G.M. 0,20 3 Daher, dds. R. pm guest Delwel, drs. S. 0,25 3 Derksen, drs. W.D.C. 0,20 3 Eekeren, drs. P.J.A. van pm guest Eijnatten, MSc. M. van 0,15 1 Eijnatten, MSc. M. van 0,30 3 Esterik, MSc. F.A.S. van 0,75 1 Evans, dds. C. pm guest Fazaeli, MSc. S. 0,75 1 Gobel, drs. J. pm guest PhD students Graaf, MSc. N.P.J. de 0,75 2 Gregor, dds. L. pm guest Grootel, drs. R.J. van pm guest Harkel, MSc. B. ten 0,45 2 Heidsieck, drs. D.S.P. pm guest Hemmatian, dds. H. pm guest Ho, dds. B.V. 0,30 2 Hol, drs. M.L.F. 0,70 3 Houwing, drs. M. pm guest Jalali, dds. R. 0,50 1 Jong, MSc. T. de 0,60 1 Kaaij, drs. N.C.W. van der 0,10 1 Karssemakers, drs. L.H.E. 0,40 1 Kelder, MSc. C.L. 0,20 1 Kommers, MSc. S.C. pm guest Kuik, drs. K. 0,20 1 Lourenco, dds. A.L.R. 0,20 3 Maarse, MSc. F. 0,40 3 Maningky, drs. M.S. pm guest Marpaung, dds. C.D. pm guest Mirahmadi, MSc. F. 0,75 3 Mokhtari-Jafari, dds. F. pm guest Muzalev, drs. K.S. pm guest Münker, ir. T.J.A.G. 0,15 2 Natsir Kalla, dds. D.S. 0,75 3 Nikolopoulou, drs. M. pm guest

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Position Name 2016 funding Nolte, drs. J.W. 0,20 1 Oomens, drs. M.A.E.M. pm guest Renders, drs. G.A.P. pm pm Restrepo Serna, drs. C.C. pm guest Ridwan, drs. A. 0,15 1 Rozeboom, drs. A.V.J. pm guest Ruiter, drs. M.H.T. de 0,20 1 Ruslin, dds. M. pm 3 Salentijn, drs. E.G. pm guest Scholtanus, drs. J.D. pm guest Schreurs, drs. R. 0,60 1 Shang, MSc. L. 0,35 3 Sprangers, MSC. S.L. 0,75 3 Sleen, drs. J.C. van der pm guest Tabeian, MSc. H. 0,15 1 Tastepe, dds. C.S. 0,35 1 PhD students Täubock, drs. T.T.K.J. pm guest Teng, dds. F. 0,75 3 Tuijt, drs. M. pm guest Thymi, drs. M. 0,30 3 Uijlenbroek, drs. H.J.J. pm guest Veldhuizen, MSc. R. 0,50 2 Velzen, drs. F.J.J. van pm guest Verlinden, drs. C.R.A. pm guest Vijfeijken, drs. S.E.C.M. van der 0,15 1 Vijfeijken, drs. S.E.C.M. van der 0,60 2 Vries, MSc. M.W. de 0,10 1 Wang, dds. D. pm 1 Zamani, dds. Y. pm guest Zande, MSc. M.M. van der 0,30 1 Zembic, dds. A. pm guest Zhang, dds. X. pm guest Zygogiannis, dds. K. 0,15 3 Total non tenured staff 27,70 total 1st funding 20,75 1 total 2nd funding 3,40 2 total 3rd funding 15,60 3 Total research staff 39,00

Output Dissertations Boffano, P. (2016, July, 4). Maxillofacial trauma: epidemiology, management and imaging, Prom./coprom.: prof.dr. T. Forouzanfar & prof.dr. E.J.A.M.Schulten. VU University Amsterdam. Chalil, S. (May 20, 2016). Understanding muscle and bone anabolic resistance in aging: is ER stress involved? Prom./coprom.: prof.dr. L. Deldicque, prof.dr. J. Klein-Nulend, dr. A.D. Bakker & dr. R.T. Jaspers. Joint PhD degree KU Leuven and Vrije Universiteit Amsterdam. Dubois, L. (2016, June 3). Predictability in orbital reconstruction. Prom./coprom.: prof.dr. A.G. Becking, prof.dr. J. de Lange, dr. P.J.J. Gooris & dr. T.J.J. Maal. Universiteit van Amsterdam. Hoogeveen, R.C. (2016, April 15). Dose reduction in orthodontic radiology. Prom./coprom.: prof.dr. P.F. van der Stelt, dr. G.C.H. Sanderink & dr. W.E.R. Berkhout. VU University Amsterdam.

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Kommers, S.C. (2016, June 21). Unilateral mandibular condyle fractures and posttraumatic dysocclusion, Prom./coprom.: prof.dr. T. Forouzanfar & dr.ir. J.H. Koolstra. VU University Amsterdam. Meursinge Reynders, R.A. (2016, October 26). Evidence-based knowledge creation on orthodontic mini- implants: Why we know so little. Prom./coprom.: prof.dr. J. de Lange & dr. B.C.M. Oosterkamp. Universiteit van Amsterdam. Scholtanus, J.D. (2016, April 14). Amalgam stained dentin: a proper substrate for bonding resin composite? Prom./coprom.: prof.dr. A.J. Feilzer, prof. dr. M. Özcan & prof.dr. C.J. Kleverlaan. Universiteit van Amsterdam. Tabeian, H. (2016, November 2). One temporomandibular joint, three different types of cartilage. The effect of inflammatory cytokines on the cartilages of the temporomandibular joint. Prom./coprom.: prof.dr. V. Everts, prof.dr. F. Lobbezoo, dr.ir. T.J. de Vries & dr. A.D. Bakker. VU University Amsterdam. Van den Bergh, B. (2016, January 28). Aspects of maxillofacial trauma care with emphasis on closed treatment of mandibular condyle fractures in an era of open reduction and internal fixation, Prom./coprom.: prof.dr. T. Forouzanfar, prof.dr. D.B. Tuinzing & dr. J.J. de Mol van Otterloo. VU University Amsterdam. Van Eekeren, P.J.A. (2016, July 1). Clinical consequences when changing the position of the implant-abutment interface, Prom./coprom.: prof.dr. D. Wismeijer & dr. A. Tahmaseb. VU University Amsterdam. Van Grootel, R.J. (2016, October 27). Pain patterns and a novel way of evaluation of therapy outcome in myogeneoustemporomandibular disorders. Prom./coprom.: prof.dr. D. Wismeijer, dr. H.W. van der Glas & dr. R. Buchner. VU University Amsterdam. Wang, D. (2016, September 21). Osteoinductive and antibacterial biomaterials for bone engineering, Prom./coprom.: prof.dr. D. Wismeijer & dr. Y. Liu. VU University Amsterdam. Wetselaar, P. (2016, July 1). The Tooth Wear Evaluation System: development and applications. Prom./coprom.: prof.dr. F. Lobbezoo, dr. M. Koutris & dr. C.M. Visscher. Universiteit van Amsterdam.

Scientific publications (refereed) Abdelaziz, M., Rizzini, A.L., Bortolotto, T., Rocca, G.T., Feilzer, A.J., Garcia-Godoy, F. & Krejci, I. (2016). Comparing different enamel pretreatment options for resin-infiltration of natural non-cavitated carious lesions. American Journal of Dentistry, vol 29, no. 1, pp. 3-9. Aboushelib, M.N., Wang, H., Kleverlaan, C.J. & Feilzer, A.J. (2016). Fatigue behavior of zirconia under different loading conditions. Dental Materials, vol 32, no. 7, pp. 915-920. DOI: 10.1016/j.dental.2016.03.012 Aceto, J., Nourizadeh-Lillabadi, R., Bradamante, S., Maier, J.A., Alestrom, P., van Loon, J.JW.A. & Muller, M. (2016). Effects of microgravity simulation on zebrafish transcriptomes and bone physiology—exposure starting at 5 days post fertilization. NPJ Microgravity, vol 2, 16010. DOI: http://dx.doi.org/10.1038/npjmgrav.2016.10 Alharbi, N., Osman, R. & Wismeijer, D. (2016). Effects of build direction on the mechanical properties of 3D- printed complete coverage interim dental restorations. Journal of Prosthetic Dentistry, vol 115, no. 6, pp. 760-767. DOI: 10.1016/j.prosdent.2015.12.002 Alharbi, N., Osman, R.B. & Wismeijer, D. (2016). Factors influencing the dimensional accuracy of 3D-printed full-coverage dental restorations using stereolithography technology. The International Journal of Prosthodontics, vol 29, no. 5, pp. 503-510. DOI: 10.11607/ijp.4835 Anami, L.C., Lima, J.M.C., Valandro, L.F., Kleverlaan, C.J., Feilzer, A.J. & Bottino, M.A. (2016). Fatigue resistance of Y-TZP/porcelain crowns is not influenced by the conditioning of the intaglio surface. Operative Dentistry, vol 41, no. 1, pp. E1-E12. DOI: 10.2341/14-166-L Anssari Moin, D., Derksen, W., Verweij, J.P., van Merkesteyn, R. & Wismeijer, D. (2016). A novel approach for computer-assisted template-guided autotransplantation of teeth with custom 3d designed/printed surgical tooling. An ex vivo proof of concept. Journal of Oral and Maxillofacial Surgery, vol 74, no. 5, pp. 895-902. DOI: 10.1016/j.joms.2016.01.033 Anssari Moin, D., Hassan, B. & Wismeijer, D. (2016). A patient specific biomechanical analysis of custom root analogue implant designs on alveolar bone stress: a finite element study. International Journal of Dentistry, vol (2016). 8242535. DOI: 10.1155/2016/8242535 Baglio, S.R., Van Eijndhoven, M.A.J., Koppers-Lalic, D., Berenguer, J., Lougheed, S.M., Gibbs, S., Léveillé, N., Rinkel, R.N.P.M., Hopmans, E.S., Swaminathan, S., Verkuijlen, S.A.W.M., Scheffer, G.L., Van Kuppeveld, F.J.M., De Gruijl, T.D., Bultink, I.E.M., Jordanova, E.S., Hackenberg, M., Piersma, S.R., Knol, J.C., Voskuyl, A.E., Wurdinger, T., Jiménez, C.R., Middeldorp, J.M. & Pegtel, D.M. (2016). Sensing of latent EBV infection

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through exosomal transfer of 5pppRNA. Proceedings of the National Academy of Sciences of the United States of America, vol 113, no. 5, pp. E587-E596. DOI: 10.1073/pnas.1518130113 Bakker, A.D., Gakes, T., Hogervorst, J.M.A., de Wit, G.M.J., Klein-Nulend J. & Jaspers, R.T. (2016). Mechanical stimulation and IGF-1 enhance mRNA translation rate in osteoblasts via activation of the AKT-mTOR pathway. Journal of Cellular Physiology, vol 231, no. 6, pp. 1283-1290. DOI: 10.1002/jcp.25228 Bastidas-Coral, A.P., Bakker, A.D., Zandieh-Doulabi, B., Kleverlaan, C.J., Bravenboer, N., Forouzanfar, T. & Klein-Nulend, J. (2016). Cytokines TNF-α, IL-6, IL-17F, and IL-4 differentially affect osteogenic differentiation of human adipose stem cells. Stem Cells International, vol (2016). 1318256. DOI: 10.1155/2016/1318256 Bergers, L.I.J.C., Reijnders, C.M.A., van den Broek, L.J., Spiekstra, S.W., de Gruijl, T.D., Weijers, E.M. & Gibbs, S. (2016). Immune-competent human skin disease models. Drug Discovery Today, vol 21, no. 9, pp. 1479- 1488. DOI: 10.1016/j.drudis.2016.05.008 Boink, M.A., Roffel, S., Nazmi, K., van Montfrans, C., Bolscher, J.G.M., Gefen, A., Veerman, E.C.I. & Gibbs, S. (2016). The influence of chronic wound extracts on inflammatory cytokine and histatin stability. PLoS One, vol 11, no. 3, 0152613. DOI: 10.1371/journal.pone.0152613 Boink, M.A., van den Broek, L.J., Roffel, S., Nazmi, K., Bolscher, J.G.M., Gefen, A., Veerman, E.C.I. & Gibbs, S. (2016). Different wound healing properties of dermis, adipose, and gingiva mesenchymal stromal cells. Wound Repair and Regeneration, vol 24, no. 1, pp. 100-109. DOI: 10.1111/wrr.12380 Boks, M.A., Gunput, S.T.G., Kosten, I., Gibbs, S., van Vliet, S.J., Ligtenberg, A.J.M. & van Kooyk, Y. (2016). The human glycoprotein salivary agglutinin inhibits the interaction of dc-sign and langerin with oral microorganisms. Journal of Innate Immunity, vol 8, no. 4, pp. 350-361. DOI: 10.1159/000443016 Bookholt, F.D., Monsuur, H.N., Gibbs, S. & Vermolen, F.J. (2016). Mathematical modelling of angiogenesis using continuous cell-based models. Biomechanics and Modeling in Mechanobiology, vol 15, no. 6, pp. 1577-1600. DOI: 10.1007/s10237-016-0784-3 Boucheron-Dubuisson, E., Manzano, A.I., Le Disquet, I., Matia, I., Saez-Vasquez, J., van Loon, J.J.W.A., Herranz, R., Carnero-Diaz, E. & Medina, F.J. (2016). Functional alterations of root meristematic cells of Arabidopsis thaliana induced by a simulated microgravity environment. Journal of Plant Physiology, vol 207, pp. 30-41. DOI: 10.1016/j.jplph.2016.09.011 Brandini, D.A., Amaral, M.F., Poi, W.R., Casatti, .CA., Bronckers, A.L.J.J., Everts, V. & Beneti, I.M. (2016). The effect of traumatic dental occlusion on the degradation of periodontal bone in rats. Indian Journal of Dental Research, vol 27, no. 6, pp. 574-580. DOI: 10.4103/0970-9290.199600 Brungs, S., Egli, M., Wuest, S.L., Christianen, P.C.M., van Loon, J.J.W.A., Ahn, T.J.N. & Hemmersbach, R. (2016). Facilities for simulation of microgravity in the ESA ground-based facility programme. Microgravity Science and Technology, vol 28, no. 3, pp. 191-203. DOI: 10.1007/s12217-015-9471-8 Buskermolen, J.K., Reijnders, C.M.A., Spiekstra, S.W., Steinberg, T., Kleverlaan, C.J., Feilzer, A.J., Bakker, A.D. & Gibbs, S. (2016). Development of a full-thickness human gingiva equivalent constructed from immortalized keratinocytes and fibroblasts. Tissue Engineering, Part. C Methods, vol 22, no. 8, pp. 781-791. DOI: 10.1089/ten.tec.2016.0066 Cao, Y., Jansen, I.D.C., Sprangers, S., Stap, J., Leenen, P.J.M., Everts, V. & de Vries, T.J. (2016). IL-1β differently stimulates proliferation and multinucleation of distinct mouse bone marrow osteoclast precursor subsets. Journal of Leukocyte Biology, vol 100, no. 3, pp. 513-523. DOI: 10.1189/jlb.1A1215-543R Chen, H., Aarab, G., de Ruiter, M.H.T., de Lange, J., Lobbezoo, F. & van der Stelt, P.F. (2016). Three- dimensional imaging of the upper airway anatomy in obstructive sleep apnea: a systematic review Sleep Medicine, vol 21, pp. 19-27. DOI: 10.1016/j.sleep.2016.01.022 Chen, H., Aarab, G., Parsa, A., de Lange, J., van der Stelt, P.F. & Lobbezoo, F. (2016). Reliability of three- dimensional measurements of the upper airway on cone beam computed tomography images. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol 122, no. 1, pp. 104-110. DOI: 10.1016/j.oooo.2016.04.005 Da Silveira, H.L.D., Damaskos, S., Arus, N.A., Tsiklakis, K. & Berkhout, E.W.R. (2016). The presence of calcifications along the course of internal carotid artery in Greek and Brazilian populations: a comparative and retrospective cone beam CT data analysis. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol 121, no. 1, pp. 81-90. DOI: 10.1016/j.oooo.2015.10.011 Daher, R., Feilzer, A.J. & Krejci, I. (2016). Novel non-invasive reinforcement of MOD cavities on endodontically treated teeth. Journal of Dentistry, vol 54, pp. 77-85. DOI: 10.1016/j.jdent.2016.09.008 Damaskos, S., da Silveira, H.L.D. & Berkhout, EW.R. (2016). Severity and presence of atherosclerosis signs within the segments of internal carotid artery: CBCT’s contribution. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol 122, no. 1, pp. 89-97. DOI: 10.1016/j.oooo.2016.03.017

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De Jong, T., Weijers, E.M., Bakker, A.D., Koolwijk, P. & Smit, T.H. (2016). Matrix remodeling and osteogenic differentiation of human adipose-derived stem cells increases with higher fibrin matrix stiffness. Journal of Biomaterials and Tissue Engineering, vol 6, no. 9, pp. 729-738. DOI: 10.1166/jbt.2016.1494 De Knegt, N.C, Lobbezoo, F., Schuengel, C., Evenhuis, H.M. & Scherder, E.J.A. (2016). Self-reporting tool on pain for people with intellectual disabilities (STOP-ID!): A usability study. Augmentative and Alternative Communication, vol 32, no. 1, pp. 1-11. DOI: 10.3109/07434618.2015.1100677 De Knegt, N.C., Schuengel, C., Evenhuis, H.M., Lobbezoo, F. & Scherder, E.J.A. (2016). Apolipoprotein E ε4, cognitive function, and pain experience in Down syndrome: A pilot study. Archives of Clinical Neuropsychology, vol 31, no. 5, pp. 389-400. DOI: 10.1093/arclin/acw022 De Knegt, N.C., Schuengel, C., Lobbezoo, F., Visscher, C.M., Evenhuis, H.M., Boel, J.A. & Scherder, E.J.A. (2016). Comprehension of pictograms for pain quality and pain affect in adults with Down syndrome. Journal of Intellectual & Developmental Disability, vol 41, no. 3, pp. 222-232. DOI: 10.3109/13668250.2016.1176129 De Kok, P., de Jager, N., Veerman, I.A.M., Hafeez, N., Kleverlaan, C.J. & Roeters, J.F.M. (2016). Effect of a retention groove on the shear bond strength of dentin-bonded restorations Journal of Prosthetic Dentistry, vol 116, no. 3, pp. 382-388. DOI: 10.1016/j.prosdent.2016.01.032 De Vries, M.W., Visscher, C., Delwel, S., van der Steen, J.T., Pieper, M.J.C., Scherder, E.J.A., Achterberg, W.P. & Lobbezoo, F. (2016). Orofacial pain during mastication in people with dementia: reliability testing of the orofacial pain scale for non-verbal individuals. Behavioural Neurology, vol (2016). 3123402. DOI: 10.1155/2016/3123402 De Vries, T.J., Yousovich, J., Schoenmaker, T., Scheres, N. & Everts, V. (2016). Tumor necrosis factor- α infliximab inhibits osteoclast formation of peripheral blood mononuclear cells but does not affect periodontal ligament fibroblast-mediated osteoclast formation. Journal of Periodontal Research, vol 51, no. 2, pp. 186-195. DOI: 10.1111/jre.12297 Dubois, L., Jansen, J., Schreurs, R., Habets, P.E.M., Reinartz, S.M., Gooris, P.J.J. & Becking, A.G. (2016). How reliable is the visual appraisal of a surgeon for diagnosing orbital fractures? Journal of Cranio-Maxillofacial Surgery, vol 44, no. 8, pp. 1015-1024. DOI: 10.1016/j.jcms.2016.05.001 Durham, J., Al-Baghdadi, M, Baad-Hansen, L., Breckons, M., Goulet, J-P., Lobbezoo, F., List, T., Michelotti, A., Nixdorf, D.R., Peck, C., Raphael, K.G., Schiffman, E., Steele, J.G., Story, W. & Ohrbach, R. (2016). Self- management programmes in temporomandibular disorders: results from an international Delphi process. Journal of Oral Rehabilitation, vol 43, no. 12, pp. 929-936. DOI: 10.1111/joor.12448 Dziewieckia, D., van de Loo, S., Gremsec, F., Kloss-Brandstätter, A., Kloss, F., Offermans, V., Yamauchi, K. & Kessler, P. (2016). Osteoneogenesis due to periosteal elevation with degradable and nondegradable devices in Göttingen minipigs. Journal of Cranio-Maxillofacial Surgery, vol 44, no. 3, pp. 318-324. DOI: http://dx.doi.org/10.1016/j.jcms.2015.12.011 Elfrink, M.E.C., Kalin, K., van Ruijven, L.J., ten Cate, J.M. & Veerkamp, J.S.J. (2016). MicroCT study on the enamel mineral density of primary molars. European Journal of Paediatric Dentistry, vol 17, no. 1, 26949242, pp. 60-64. Emodi Perlman, A., Lobbezoo, F., Zar, A., Friedman Rubin, P., van Selms, M.K.A. & Winocur, E. (2016). Self- Reported bruxism and associated factors in Israeli adolescents. Journal of Oral Rehabilitation, vol 43, no. 6, pp. 443-450. DOI: 10.1111/joor.12391 Fage, S.W., Jakobsen, S.S., Thyssen, J.P. & Muris, J. (2016). Titanium: a review on exposure, release, penetration, allergy, epidemiology, and clinical reactivity. Contact Dermatitis, vol 74, no. 6, pp. 323-345. DOI: 10.1111/cod.12565 Fazaeli, S., Ghazanfari, S.,. Everts, V., Smit, T.H. & Koolstra, J.H. (2016). The contribution of collagen fibers to the mechanical compressive properties of the temporomandibular joint disc. Osteoarthritis and Cartilage, vol 24, no. 7, pp. 1292-1301. DOI: 10.1016/j.joca.2016.01.138 Fijnheer, C., Langhorst, F.R. & Wismeijer, D. (2016). Evaluation of the implant-related restorative undergraduate programme at ACTA, the Netherlands. Part I: students satisfaction. European Journal of Dental Education, vol 20, no. 2, pp. 84-93. DOI: 10.1111/eje.12145 Fraga, S., Pereira, G.K.R., Freitas, M., Kleverlaan, C.J., Valandro, L.F. & May, L.G. (2016). Loading frequencies up to 20 Hz as an alternative to accelerate fatigue strength tests in a Y-TZP ceramic. Journal of the Mechanical Behavior of Biomedical Materials, vol 61, pp. 79-86. DOI: 10.1016/j.jmbbm.2016.01.008 Frett, T., Petrat, G., van Loon, J.J.W.A., Hemmersbach, R. & Anken, R. (2016). Hypergravity facilities in the ESA ground-based facility program: current research activities and future tasks. Microgravity Science and Technology, vol 28, no. 3, pp. 205-214. DOI: 10.1007/s12217-015-9462-9 Gardien, K.L.M., Marck, R.E., Bloemen, M.C.T., Waaijman, T., Gibbs, S., Uhlrich, M.M.W. & Middelkoop, E. (2016). Outcome of burns treated with autologous cultured proliferating epidermal cells: a prospective

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randomized multicenter intrapatient comparative trial. Cell Transplantation, vol 25, no. 3, pp. 437-448. DOI: 10.3727/096368915X689569 Gilijamse, M., Baart, J.A., Wolff, J,. Sandor, G.K. & Forouzanfar, T. (2016). Tooth autotransplantation in the anterior maxilla and mandible: retrospective results in young patient.s Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol 122, no. 6, pp. e187-e192. DOI: 10.1016/j.oooo.2016.06.013 Gregor, L., Krejci, I., Di Bella, R., Feilzer, A.J. & Ardu, S. (2016). Silorane, ormocer, methacrylate and compomer long-term staining susceptibility using Delta E and Delta E-00 colour-difference formulas. Odontology, vol 104, no. 3, pp. 305-309. DOI: 10.1007/s10266-015-0212-7 Guo, J., Bervoets, T.J.M., Henriksen, K., Everts, V. & Bronckers, A.L.J.J. (2016). Null mutation of chloride channel 7 (Clcn7) impairs dental root formation but does not affect enamel mineralization. Cell and Tissue Research, vol 363, no. 2, pp. 361-370. DOI: 10.1007/s00441-015-2263-z Hoogeveen, R.C., Hazenoot, B, Sanderink, GCH & Berkhout, W.E.R. (2016). The value of thyroid shielding in intraoral radiography Dentomaxillofacial Radiology, vol 45, no. 5, 20150407. DOI: 10.1259/dmfr.20150407 Huang, H., Wismeijer, D., Shao, X & Wu, G (2016). Mathematical evaluation of the influence of multiple factors on implant stability quotient values in clinical practice: A retrospective study. Therapeutics and Clinical Risk Management, vol 12, pp. 1525-1532. DOI: 10.2147/TCRM.S113764 Huynh, N.C.N., Everts, V., Leethanakul, C., Pavasant, P. & Ampornaramveth, R.S. (2016). Rinsing with saline promotes human gingival fibroblast wound healing in vitro. PLoS One, vol 11, no. 7, e0159843. DOI: 10.1371/journal.pone.0159843 Huynh, N.C-N., Everts, V., Pavasant, P. & Ampornaramveth, R.S. (2016). Inhibition of histone deacetylases enhances the osteogenic differentiation of human periodontal ligament cells Journal of Cellular Biochemistry, vol 117, no. 6, pp. 1384-1395. DOI: 10.1002/jcb.25429 Jepsen, K., Jepsen, S., Laine, M.L., Anssari Moin, D., Pilloni, A., Zeza, B., Sanz, M., Ortiz-Vigon, A., Roos- Jansaker, A.M. & Renvert, S. (2016). Reconstruction of peri-implant osseous defects: a multicenter randomized trial. Journal of Dental Research, vol 95, no. 1, pp. 58-66. DOI: 10.1177/0022034515610056 Jonkergouw, J., van de Vijfeijken, S.E.C.M., Nout, E., Theys, T., Van de Casteele, E., Folkersma, H., Depauw, P.R.A.M. & Becking, A.G. (2016). Outcome in patient-specific PEEK cranioplasty: a two-center cohort study of 40 implants. Journal of Cranio-Maxillofacial Surgery, vol 44, no. 9, pp. 1266-1272. DOI: 10.1016/j.jcms.2016.07.005 Kalenderian, E., Tokede, B., Ramoni, .R, Khan, M., Kimmes, N., White, J., Vaderhobli, R., Yansane, A. & Feilzer, A. (2016). Dental clinical research: an illustration of the value of standardized diagnostic terms. Journal of Public Health, vol 76, no. 2, pp. 152-160 . DOI: 10.1111/jphd.12124 Kamal, K.Y., Herranz, R., van Loon, J.J.W.A., Christianen, P.C.M. & Medina, F.J. (2016). Evaluation of simulated microgravity environments induced by diamagnetic levitation of plant cell suspension cultures. Microgravity Science and Technology, vol 28, no. 3, pp. 309-317. DOI: 10.1007/s12217-015-9472-7 Kingma, S.D.K., Wagemans, T, Ijlst, L., Bronckers, A.L.J.J., van Kuppevelt, T.H., Everts, V., Wijburg, F.A. & van Vlies, N. (2016). Altered interaction and distribution of glycosaminoglycans and growth factors in mucopolysaccharidosis type I bone disease. Bone, vol 88, pp. 92-100. DOI: 10.1016/j.bone.2016.01.029 Korfage, J.A.M., Kwee, K.E., Everts, V. & Langenbach, G.E.J. (2016). Myosin heavy chain expression can vary over the length of jaw and leg muscles. Cells Tissues Organs, vol 201, no. 2, pp. 130-137. DOI: 10.1159/000443606 Kosten, I.J., Spiekstra, S.W., De Gruijl, T.D. & Gibbs, S. (2016). MUTZ-3 langerhans cell maturation and CXCL12 independent migration in reconstructed human gingiva. Altex-Alternatives To Animal Experimentation, vol 33, no. 4, pp. 423-434. DOI: 10.14573/altex.1510301 Koutris, M., Türker, K.S., van der Weijden, J.J., van Selms, M. & Lobbezoo, F. (2016). Two different analyzing methods for inhibitory reflexes: Do they yield comparable outcomes? Journal of Neuroscience Methods, vol 274, pp. 49-52. DOI: 10.1016/j.jneumeth.2016.10.003 Kuijs, R., van Dalen, A., Roeters, J. & Wismeijer, D. (2016). The resin-bonded fixed partial denture as the first treatment consideration to replace a missing tooth. The International Journal of Prosthodontics, vol 29, no. 4, pp. 337-339. DOI: 10.11607/ijp.4412 Limonard, E.J., Schoenmaker, T., de Vries, T.J., Tanck, M., Heijboer, A.C., Endert, E., Fliers, E., Everts, V. & Bisschop, P.H. (2016). Clonidine increases bone resorption in humans. Osteoporosis International, vol 27, no. 3, pp. 1063-1071. DOI: 10.1007/s00198-015-3312-x Liu, T., Zhang, X., Luo, Y., Huang, Y. & Wu, G. (2016). Slowly-delivered icariin/allogeneic bone marrow-derived mesenchymal stem cells to promote the healing of calvarial critical-size bone defects Stem Cells International, vol (2016). pp. 1416047. DOI: 10.1155/2016/1416047

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Liu, Y., Lin, Z., Guo, J., Xu, G., Li, Y, Xu, T., Lv., H., Chen, J. & Wu, G. (2016). Notoginsenoside R1 significantly promotes in vitro osteoblastogenesis International Journal of Molecular Medicine, vol 38, no. 2, pp. 537- 544. DOI: 10.3892/ijmm.2016.2652 Lobbezoo, F., Aarab, G., Wetselaar, P., Hoekema, A., de Lange, J. & de Vries, N. (2016). A new definition of dental sleep medicine. Journal of Oral Rehabilitation, vol 43, no. 10, pp. 786-790. DOI: 10.1111/joor.12421 Lövgren, A., Haggman-Henrikson, B., Visscher, C.M., Lobbezoo, F., Marklund, S. & Wanman, A. (2016). Temporomandibular pain and jaw dysfunction at different ages covering the lifespan - A population based study. European Journal of Pain, vol 20, no. 4, pp. 532-540. DOI: 10.1002/ejp.755 Lövgren, A., Visscher, C.M., Häggman-Henrikson, B., Lobbezoo, F., Marklund, S. & Wänman, A. (2016). Validity of three screening questions (3Q/TMD) in relation to the DC/TMD. Journal of Oral Rehabilitation, vol 43, no. 10, pp. 729-36. DOI: 10.1111/joor.12428 Lu, H., Liu, Y., Guo, J., Wu, H., Wang, J. & Wu, G. (2016). Biomaterials with antibacterial and osteoinductive properties to repair infected bone defects. International Journal of Molecular Sciences, vol 17, no. 3, 334. DOI: 10.3390/ijms17030334 Lübbers, J., van Beers-Tas, M.H., Vosslamber, S., Turk, S.A., de Ridder, S., Mantel, E., Wesseling, J.G., Reijm, M., van Hoogstraten, I.M., Bijlsma, J.W., van Schaardenburg, D., Bontkes, H.J. & Verweij, C.L. (2016). Changes in peripheral blood lymphocyte subsets during arthritis development in arthralgia patients. Arthritis Research & Therapy, vol 18, 205. DOI: 10.1186/s13075-016-1102-2 Ma, D., Kou, X., Jin, J., Xu, T., Wu, M., Deng, L., Fu, L., Liu, Y., Wu, G. & Lu, H. (2016). Hydrostatic compress force enhances the viability and decreases the apoptosis of condylar chondrocytes through integrin-FAK- ERK/PI3K pathway. International Journal of Molecular Sciences, vol 17, no. 11, 1847. DOI: 10.3390/ijms17111847 Manzano, A.I., Herranz, R., Manzano, A., van Loon, J.J.W.A. & Medina, F.J. (2016). Early effects of altered gravity environments on plant cell growth and cell proliferation: characterization of morphofunctional nucleolar types in an Arabidopsis cell culture system. Frontiers in Astronomy and Space Sciences, vol 3. DOI: 10.3389/fspas.2016.00002 Martin, W.J., Skorpil, N.E., Ashton-James, C.E., Tuinzing, D.B. & Forouzanfar, T. (2016). Effect of vasoconstriction on pain after mandibular third molar surgery: a single-blind, randomized controlled trial. Quintessence International, vol 47, no. 7, pp. 589-596. DOI: 10.3290/j.qi.a36174 Micha, D., Voermans, E., Eekhoff, M.E.W., van Essen, H.W., Zandieh-Doulabi, B., Netelenbos, C., Rustemeyer, T., Sistermans, E.A., Pals, G. & Bravenboer, N. (2016). Inhibition of TGFβ signaling decreases osteogenic differentiation of fibrodysplasia ossificans progressiva fibroblasts in a novel in vitro model of the disease. Bone, vol 84, pp. 169-180. DOI: 10.1016/j.bone.2016.01.004 Michelotti, A., Alstergren, P., Goulet, J.P., Lobbezoo, F., Ohrbach, R., Peck, C., Schiffman, E. & List, T. (2016). Next steps in development of the diagnostic criteria for temporomandibular disorders (DC/TMD): recommendations from the International RDC/TMD Consortium Network workshop. Journal of Oral Rehabilitation, vol 43, no. 6, pp. 453-467. DOI: 10.1007/s10658-016-0887-9 Michiels, S., Naessens, .S, van de Heyning, P., Braem, M., Visscher, C.M., Gilles, A. & de Hertogh, W. (2016). The effect of physical therapy treatment in patients with subjective tinnitus: A systematic review. Frontiers in Neuroscience, vol 10, 545. DOI: 10.3389/fnins.2016.00545 Milheiro, A., Nozaki, K., Kleverlaan, C.J., Muris, J., Miura, H. & Feilzer, A.J. (2016). In vitro cytotoxicity of metallic ions released from dental alloys. Odontology, vol 104, no. 2, pp. 136-142. DOI: 10.1111/joor.12378 Monsuur, H.N., Boink, M.A., Weijers, E.M., Roffel, S., Breetveld, M., Gefen, A., van den Broek, L.J. & Gibbs, S. (2016). Methods to study differences in cell mobility during skin wound healing in vitro. Journal of Biomechanics, vol 49, no. 8, pp. 1381-1387. DOI: 10.1016/j.jbiomech.2016.01.040 Monsuur, H.N., Weijers, E.M., Niessen, F.B., Gefen, A., Koolwijk, P., Gibbs, S. & van den Broek, L.J. (2016). Extensive characterization and comparison of endothelial cells derived from dermis and adipose tissue: Potential use in tissue engineering. PLoS One, vol 11, no. 11, e0167056. DOI: 10.1371/journal.pone.0167056 Mourits, D.L., Wolff, J., Forouzanfar, T., Ridwan-Pramana, A., Moll, A.C., de Graaf, P., Remmers, J.S., Kraal- Biezen, E. & Hartong, D.T. (2016). 3D orbital reconstruction in a patient with microphthalmos and a large orbital cyst - a case report Ophthalmic Genetics, vol 37, no. 2, pp. 233-237. DOI: 10.3109/13816810.2015.1033558 Navarro, L., Mogosanu, D.E., de Jong, T., Bakker, A.D., Schaubroeck, D., Luna, J., Rintoul, I., Vanfleteren, J. & Dubruel, P. (2016). Poly(polyol sebacate) Elastomers as Coatings for Metallic Coronary Stents Macromolecular Bioscience, vol 16, no. 11, pp. 1678-1692. DOI: 10.1002/mabi.201600105

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Pathak, J.L., Bakker, A.D., Luyten, F.P., Verschueren, P., Lems, W.F., Klein-Nulend, J. & Bravenboer, N. (2016). Systemic inflammation affects human osteocyte-specific protein and cytokine expression. Calcified Tissue International, vol 98, no. 6, pp. 596-608. DOI: 10.1007/s00223-016-0116-8 Pathak, J.L., Verschueren, P., Lems, W.F., Bravenboer, N., Klein-Nulend, J., Bakker, A.D. & Luyten, F.P. (2016). Serum of patients with active rheumatoid arthritis inhibits differentiation of osteochondrogenic precursor cells. Connective Tissue Research, vol 57, no. 3, pp. 226-235. DOI: 10.3109/03008207.2016.1146714 Pereira, G.K.R., Fraga, S., Montagner, A.F., Soares, F.Z.M., Kleverlaan, C.J. & Valandro, L.F. (2016). The effect of grinding on the mechanical behavior of Y-TZP ceramics: A systematic review and meta-analyse.s Journal of the Mechanical Behavior of Biomedical Materials, vol 63, pp. 417-442. DOI: 10.1016/j.jmbbm.2016.06.028 Pereira, G.K.R., Muller, C., Wandscher, V.F., Rippe, MP, Kleverlaan, C.J. & Valandro, L.F. (2016). Comparison of different low-temperature aging protocols: its effects on the mechanical behavior of Y-TZP ceramics. Journal of the Mechanical Behavior of Biomedical Materials, vol 60, pp. 324-330. DOI: 10.1016/j.jmbbm.2016.02.017 Pereira, GK..R., Silvestri, T., Amaral, M., Rippe, M.P., Kleverlaan, C.J. & Valandro, L.F. (2016). Fatigue limit of polycrystalline zirconium oxide ceramics: effect of grinding and low-temperature aging. Journal of the Mechanical Behavior of Biomedical Materials, vol 61, pp. 45-64. DOI: 10.1016/j.jmbbm.2016.01.006 Pereira, G.K.R., Silvestri, T., Camargo, R., Rippe, M..P, Amaral, M., Kleverlaan, C.J. & Valandro, L.F. (2016). Mechanical behavior of a Y-TZP ceramic for monolithic restorations: effect of grinding and low- temperature aging. Materials Science & Engineering C-Materials for Biological Applications, vol 63, pp. 70- 77. DOI: 10.1016/j.msec.2016.02.049 Potze, L., Franco, S., Grandela, C., Pras-Raves, M.L., Picavet, D.I., van Veen, H.A., van Lenthe, H., Mullauer, F.B., van der Wel, N.N., Luyf, .A.C.M, van Kampen, A.H.C., Kemp, S., Everts, V., Kessler, J.H., Vaz, F.M. & Medema, J.P. (2016). Betulinic acid induces a novel cell death pathway that depends on cardiolipin modification. Oncogene, vol 35, no. 4, pp. 427-437. DOI: 10.1038/onc.2015.102 Prins, H.J., Schulten, E.A.J.M., ten Bruggenkate, C.M., Klein-Nulend, J. & Helder, M.N. (2016). Bone regeneration using the freshly isolated autologous stromal vascular fraction of adipose tissue in combination with calcium phosphate ceramics. Stem Cells Translational Medicine, vol 5, no. 10, pp. 1362- 1374. DOI: 10.5966/sctm.2015-0369 Pull ter Gunne, L., Dikkes, B., Wismeijer, D. & Hassan, B. (2016). Immediate and early loading of two-implant- supported mandibular overdentures:: three-year report of loading results of a single-center prospective randomized controlled clinical trial. International Journal of Oral & Maxillofacial Implants, vol 31, no. 5, pp. 1110-6. Raphael, K.G., Santiago, V. & Lobbezoo, F. (2016). Is bruxism a disorder or a behaviour? Rethinking the international consensus on defining and grading of bruxism. Journal of Oral Rehabilitation, vol 43, no. 10, pp. 791-798. DOI: 10.1111/joor.12413 Ridwan-Pramana, A., Marcián, P., Borák, L., Narra, N., Forouzanfar, T. & Wolff, J. (2016). Structural and mechanical implications of PMMA implant shape and interface geometry in cranioplasty - A finite element study. Journal of Cranio-Maxillofacial Surgery, vol 44, no. 1, pp. 34-44. DOI: 10.1016/j.jcms.2015.10.014 Rocca, G.T., Sarrati, C.M., Poncet, A., Feilzer, A.J. & Krejci, I. (2016). The influence of FRCs reinforcement on marginal adaptation of CAD/CAM composite resin endocrowns after simulated fatigue loading. Odontology, vol 104, no. 2, pp. 220-232. DOI: 10.1007/s10266-015-0202-9 Rocca, G.T., Sedlakova, P., Saratti, C.M., Sedlacek, R., Rizcalla, N., Feilzer, A.J. & Krejci, .I (2016). Fatigue behavior of resin-modified monolithic CAD-CAM RNC crowns and endocrowns. Dental Materials, vol 32, no. 12, pp. e338-e350. DOI: 10.1016/j.dental.2016.09.024 Ruiz-Zapata, A.M., Kerkhof, M.H., Ghazanfari, S., Zandieh-Doulabi, B., Stoop, R., Smit, T.H. & Helder, M.N. (2016). Vaginal fibroblastic cells from women with pelvic organ prolapse produce matrices with increased stiffness and collagen content. Scientific Reports, vol 6, 22971. DOI: 10.1038/srep22971 Ruslin, M., Boffano, .P, ten Brincke, Y.J.D., Forouzanfar, T. & Brand, H.S. (2016). Sport-related maxillofacial fractures. The Journal of Craniofacial Surgery, vol 27, no. 1, pp. e91-e94. DOI: 10.1097/SCS.0000000000002242 Salehi-Nik, N., Amoabediny, G., Banikarimi, S.P., Pouran, B., Malaie-Balasi, Z., Zandieh-Doulabi, B. & Klein- Nulend, J. (2016). Nanoliposomal Growth hormone and sodium nitrite release from silicone fibers reduces thrombus formation under flow. Annals of Biomedical Engineering, vol 44, no. 8, pp. 2417-30. DOI: 10.1007/s10439-015-1529-7 Salehi-Nik, N., Amoabediny, G., Solouk, A., Shokrgozar, M.A., Zandieh-Doulabi, B. & Klein-Nulend, J. (2016). Biomimetic modification of silicone tubes using sodium nitrite-collagen immobilization accelerates

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endothelialization. Journal of Biomedical Materials Research. Part B Applied Biomaterials, vol 104, no. 7, pp. 1311-21. DOI: 10.1002/jbm.b.33412 Schreurs, R., Dubois, L., Becking, A.G. & Maal, T.J.J. (2016). Quantitative assessment of orbital implant position - a proof of concept. PLoS One, vol 11, no. 3, e0150162, pp. e0150162. DOI: 10.1371/journal.pone.0150162 Shah, K.M., Stern, M.M., Stern, A.R., Pathak, J.L., Bravenboer, N. & Bakker, A.D. (2016). Osteocyte isolation and culture methods. BoneKEy Reports, vol 5, pp. 838. DOI: 10.1038/bonekey.2016.65 Sprangers, S., de Vries, T.J. & Everts, V. (2016). Monocyte heterogeneity: consequences for monocyte-derived immune cells. Journal of Immunology Research, vol (2016). 1475435. DOI: 10.1155/2016/1475435 Sprangers, S., Schoenmaker, T., Cao, Y., Everts, V. & de Vries, T.J. (2016). Different blood-borne human osteoclast precursors respond in distinct ways to IL-17A. Journal of Cellular Physiology, vol 231, no. 6, pp. 1249-1260. DOI: 10.1002/jcp.25220 Tabeian, H., Bakker, A.D., de Vries, T.J., Zandieh-Doulabi, B., Lobbezoo, F. & Everts, V. (2016). Juvenile porcine temporomandibular joint: three different cartilaginous structures? Archives of Oral Biology, vol 72, pp. 211-218. DOI: 10.1016/j.archoralbio.2016.08.033 Tan, C.X.W., Brand, H.S., de Boer, N.K.H. & Forouzanfar, T. (2016). Gastrointestinal diseases and their orodental manifestations: part 1: Crohns disease. British Dental Journal, vol 221, no. 12, pp. 794-799. DOI: 10.1038/sj.bdj.2016.954 Ten Harkel, B, Koopsen, J., Putten, S.M., van Veen, H., Picavet, D.I., de Vries, T.J., Bank, R.A. & Everts, V. (2016). Ultrastructural aspects of foreign body giant cells generated on different substrates. Journal of Structural Biology, vol 195, no. 1, pp. 31-40. DOI: 10.1016/j.jsb.2016.04.016 Titinchi, F., Hassan, B.A., Morkel, J.A. & Nortje, C. (2016). Odontogenic myxoma: a clinicopathological study in a South African population. Journal of Oral Pathology & Medicine, vol 45, no. 8, pp. 599-604. DOI: 10.1111/jop.12421 Toxopeus, A.H., Husebo, B.S., Strand, L.I., Delwel, S., van Wijk, A.J., Scherder, E.J.A. & Lobbezoo, F. (2016). The mouth care item of the MOBID pain scale: secondary analyses of unique video uptakes by dental professionals. Gerodontology, vol 33, no. 1, pp. 61-68. DOI: 10.1111/ger.12115 Trindade, F.Z., Kleverlaan, C.J., da Silva, L.H., Feilzer, A.J., Cesar, P.F., Bottino, M.A. & Valandro, L.F. (2016). Ceramic inlays: effect of mechanical cycling and ceramic type on restoration-dentin bond strength. Operative Dentistry, vol 41, no. 4, pp. E102-E117. DOI: 10.2341/14-155-L Tuijt, M., Koolstra, J.H., Lobbezoo, F. & Naeije, M. (2016). How muscle relaxation and laterotrusion resolve open locks of the temporomandibular joint. Forward dynamic 3D-modeling of the human masticatory system. Journal of Biomechanics, vol 49, no. 2, pp. 276-283. DOI: 10.1016/j.jbiomech.2015.12.003 Van der Meijden, K., Bakker, A.D., van Essen, H.W., Heijboer, A.C., Schulten, E.A.J.M., Lips, P .& Bravenboer, N. (2016). Mechanical loading and the synthesis of 1,25(OH)2D in primary human osteoblasts Journal of Steroid Biochemistry and Molecular Biology, vol 156, pp. 32-39. DOI: 10.1016/j.jsbmb.2015.11.014 Van der Meijden, K., Buskermolen, J., van Essen, H.W., Schuurman, T., Steegenga, W.T., Brouwer-Brolsma, E.M, Langenbach, G.E.J., van Ruijven, L.J., den Heijer, M., Lips, P. & Bravenboer, N. (2016). Long-term vitamin D deficiency in older adult C57BL/6 mice does not affect bone structure, remodeling and mineralization. Journal of Steroid Biochemistry and Molecular Biology, vol 164, pp. 344-352. DOI: 10.1016/j.jsbmb.2015.09.004 Van der Meijden, K., van Essen, H.W., Bloemers, F.W., Schulten, E.A.J.M., Lips, P. & Bravenboer, N. (2016). Regulation of CYP27B1 mRNA expression in primary human osteoblasts. Calcified Tissue International, vol 99, no. 2, pp. 164-173. DOI: 10.1007/s00223-016-0131-9 Van Eekeren, P.J.A., Aartman, I.H.A., Tahmaseb, A. & Wismeijer, D. (2016). The effect of implant placement in patients with either Kennedy class II and III on oral health-related quality of life: A prospective clinical trial. Journal of Oral Rehabilitation, vol 43, no. 4, pp. 291-296. DOI: 10.1111/joor.12370 Van Eijnatten, M., Rijkhorst, E.J., Hofman, M., Forouzanfar, T. & Wolff, J. (2016). The accuracy of ultrashort echo time MRI sequences for medical additive manufacturing. Dentomaxillofacial Radiology, vol 45, no. 5, 20150424. DOI: 10.1259/dmfr.20150424 Van Esterik, F.A.S., Zandieh-Doulabi, B., Kleverlaan, C.J. & Klein-Nulend, J. (2016). Enhanced osteogenic and vasculogenic differentiation potential of human adipose stem cells on biphasic calcium phosphate scaffolds in fibrin gels. Stem Cells International, vol (2016). 1934270. DOI: 10.1155/2016/1934270 Van Groningen, L., Sips, R., Wismeijer, D. & Hassan, B. (2016). Comparing 2 cone beam computed tomography devices for the transfer accuracy of a laboratory-based guided surgery system in vitro. Implant Dentistry, vol 25, no. 2, pp. 222-226. DOI: 10.1097/ID.0000000000000361 Van Loon, J.J.W.A. (2016). Centrifuges for microgravity simulation. The reduced gravity paradigm. Frontiers in Astronomy and Space Sciences, vol 3, 21. DOI: http://dx.doi.org/10.3389/fspas.2016.00021

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Van Velzen, F.J.J., Lang, N.P., Schulten, E.A.J.M. & ten Bruggenkate, C.M. (2016). Dental floss as a possible risk for the development of peri-implant disease: an observational study of 10 cases. Clinical Oral Implants Research, vol 27, no. 5, pp. 618-621. DOI: 10.1111/clr.12650 Vehmeijer, M., van Eijnatten, M., Liberton, N. & Wolff, J. (2016). A novel method of orbital floor reconstruction using virtual planning, 3-dimensional printing, and autologous bone Journal of Maxillofacial & Oral Surgery, vol 74, no. 8, pp. 1608-1612. DOI: 10.1016/j.joms.2016.03.044 Vehmeijer, M.J.J.B., Verstoep, N., Wolff, J.E.H., Schulten, E.A.J.M. & van den Berg, B. (2016). Airway management of a patient with an acute floor of the mouth hematoma after dental implant surgery in the lower jaw. Journal of Emergency Medicine, vol 51, no. 6, pp. 721-724. DOI: 10.1016/j.jemermed.2016.07.099 Vermeer, J.A.F., Renders, G.A.P. & Everts, V. (2016). Osteonecrosis of the jaw-a bone site - specific effect of bisphosphonates. Current Osteoporosis Reports, vol 14, no. 5, pp. 219-225. DOI: 10.1007/s11914-016- 0318-z Versari, S., Barenghi, L., van Loon, J. & Bradamante, S (2016). The SCD - Stem Cell Differentiation ESA project: preparatory work for the spaceflight mission. Microgravity Science and Technology, vol 28, no. 1, pp. 19-28. DOI: 10.1007/s12217-015-9466-5 Verweij, J.P., Moin, D.A., Mensink, G., Nijkamp, P., Wismeijer, D. & van Merkesteyn, J.P.R. (2016). Autotransplantation of premolars with a 3-dimensional printed titanium replica of the donor tooth functioning as a surgical guide: proof of concept. Journal of Oral and Maxillofacial Surgery, vol 74, no. 6, pp. 1114-1119. DOI: 10.1016/j.joms.2016.01.030 Visscher, D.O., Farré-Guasch, E., Helder, M.N., Gibbs, S., Forouzanfar, T., van Zuijlen, P.P. & Wolff, J. (2016). Advances in bioprinting technologies for craniofacial reconstruction. Trends in Biotechnology, vol 34, no. 9, pp. 700-710. DOI: 10.1016/j.tibtech.2016.04.001 Vuorjoki-Ranta, T.R., Lobbezoo, F., Vehkalahti, M., Tuomilehto, H. & Ahlberg, J. (2016). Treatment of obstructive sleep apnoea patients in community dental care: knowledge and attitudes among general dental practitioners and specialist dentists. Journal of Oral Rehabilitation, vol 43, no. 12, pp. 937-942. DOI: 10.1111/joor.12441 Wan, Q., Schoenmaker, T., Jansen, I.D.C., Bian, Z., de Vries, T.J. & Everts, V. (2016). Osteoblasts of calvaria induce higher numbers of osteoclasts than osteoblasts from long bone Bone, vol 86, pp. 10-21. DOI: 10.1016/j.bone.2016.02.010 Wang, L., Hu, H., Cheng, Y., Chen, J., Bao, C., Zou, S. & Wu, G. (2016). Screening the expression changes in microRNAs and their target genes in mature cementoblasts stimulated with cyclic tensile stress. International Journal of Molecular Sciences, vol 17, no. 12, 2024. DOI: 10.3390/ijms17122024 Wetselaar, P., Vermaire, J.H., Visscher, C.M., Lobbezoo, F., Schuller, A.A. (2016). The prevalence of tooth wear in the Dutch adult population. Caries Research, vol 50, no. 6, pp. 543-550. DOI: 10.1159/000447020 Wetselaar, P. & Lobbezoo, F. (2016). The tooth wear evaluation system: a modular clinical guideline for the diagnosis and management planning of worn dentitions. Journal of Oral Rehabilitation, vol 43, no. 1, pp. 69-80. DOI: 10.1111/joor.12340 Wetselaar, P., Faris, A. & Lobbezoo, F. (2016). A plea for the development of an universally accepted modular tooth wear evaluation system BMC Oral Health, vol 16, 115. DOI: 10.1186/s12903-016-0309-6 Wetselaar, P., Wetselaar-Glas, M.J.M., Koutris, M., Visscher, C.M. & Lobbezoo, F. (2016). Assessment of the amount of tooth wear on dental casts and intra-oral photographs. Journal of Oral Rehabilitation, vol 43, no. 8, pp. 615-620. DOI: 10.1111/joor.12405 Wolff, J., Farré-Guasch, E, Sándor, G.K., Gibbs, S., Jager, D.J. & Forouzanfar, T. (2016). Soft tissue augmentation techniques and materials used in the oral cavity: an overview. Implant Dentistry, vol 25, no. 3, pp. 427-434. DOI: 10.1097/ID.0000000000000385 Wolff, J., Karagozoglu, K.H., Bretschneider, J.H., Forouzanfar, T. & Schulten, E.A.J.M. (2016). Altered nasal airflow: an unusual complication following implant surgery in the anterior maxilla International. Journal of Implant Dentistry, vol 2, 6. DOI: 10.1186/s40729-016-0045-3 Yönel, N., Bikker, F.J., Lagerweij, M.D., Kleverlaan, C.J., van Loveren, C., Özen, B., Çetiner, S. & van Strijp, A.J.P. (2016). Anti-erosive effects of fluoride and phytosphingosine: an in vitro study. European Journal of Oral Sciences, vol 124, no. 4, pp. 396-402. DOI: 10.1111/eos.12283 Zarauz, C., Valverde, A., Martinez-Rus, F., Hassan, B. & Pradies, G. (2016). Clinical evaluation comparing the fit of all-ceramic crowns obtained from silicone and digital intraoral impressions. Clinical Oral Investigations, vol 20, no. 4, pp. 799-806. DOI: 10.1007/s00784-015-1590-5

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Zygogiannis, K., Wismeijer, D. & Parsa, A. (2016). A pilot study on mandibular overdentures retained by mini dental implants: Marginal bone level changes and patient-based ratings of clinical outcome. International Journal of Oral & Maxillofacial Implants, vol 31, no. 5, pp. 1171-1178. DOI: 10.11607/jomi.4339 Zygogiannis, K., Wismeijer, D., Aartman, I.H.A & Osman, R.B. (2016). A systematic review on immediate loading of implants used to support overdentures opposed by conventional prostheses: factors that might influence clinical outcomes. International Journal of Oral & Maxillofacial Implants, vol 31, no. 1, pp. 63-72. DOI: 10.11607/jomi.4028

Other scientific publications Lobbezoo, F., Koyano, K., Paesani, D.A. & Manfredini, D. (2016). Sleep bruxism: Diagnostic considerations. in M.H. Kryger, T. Roth & W.C. Dement (eds), Principles and Practice of Sleep Medicine. 6 edn, Elsevier, Philadelphia, pp. 1427-1434e. DOI: 10.1016/B978-0-323-24288-2.00145-8 Lobbezoo, F., Manfredini, D. & Bracci, A. Bruxism. The right clinical information, right where its needed. (2016). Web publication/site. Manfredini, D., Mura, R., Ahlberg, J. & Lobbezoo, F. (2016). Letter to the Editor: Authors Response. Journal of Periodontology, vol 87, no. 1, pp. 3-4. DOI: 10.1902/jop.2016.150409 Raphael, K.G., Santiago, V. & Lobbezoo, F. (2016). Bruxism is a continuously distributed behaviour, but disorder decisions are dichotomous (Response to letter by Manfredini, De Laat, Winocur, & Ahlber). Journal of Oral Rehabilitation, vol 43, no. 10, pp. 802-803. DOI: 10.1111/joor.12425 Vanderveken, O.M., Hoekema, A. & Weaver, E. (2016). Upper airway surgery to treat obstructive sleep- disordered breathing. in M.H. Kryger, T. Roth & W.C. Dement (eds), Principles and Practice of Sleep Medicine. 6 edn, Elsevier, Philadelphia, pp. 1463-1477. Wetselaar, P. & Lobbezoo, F. (2016). The Tooth Wear Evaluation System (TWES): a modular clinical guideline for the diagnosis and management planning of worn dentitions. Part 1: introduction, diagnostic modules, and classification: Part 1: introduction, diagnostic modules, and classification. Journal of Craniomandibular Function, vol 8, no. 4, pp. 313-326.

Professional publications Baart, J.A. & Bosgra, J.F.L. (2016). Dentogene pijnklachten. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 10, pp. 484-490. DOI: 10.5177/ntvt.2016.10.16108 Baart, J.A. & Bosgra, J.F.L. (2016). Nabloeding. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 12, no. 2, pp. 33-39. Baart, J.A., Bosgra, J.F.L. & Gilijamse, M. (2016). Computergestuurde lokale anesthesie in de tandheelkunde. Dental Tribune, vol 10, pp. 17-19. Baart, J.A. & van der Waal, I. (2016). Het focusvrij maken van de mond. Quality Practice Assistenten, vol 3, no. 2, pp. 14-17. Baart, J.A. & van der Waal, I. (2016). Röntgendiagnostiek in de kaakchirurgie: enkele voorbeelden. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 11, no. 5, pp. 39-44. Becking, A.G. (2016). Bestralingsgeïnduceerde osteomyelitis. [Bespreking van: L.J. Poort (2015) Evaluation of the effects of irradiation on bone and osteoradionecrosis of the mandible in a large animal model]. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 6, pp. 329. Beerens, M.W. & van der Veen, M.H. (2016). Detectie en preventie van wittevleklaesies tijdens en na de orthodontische behandeling met vaste apparatuur. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 12, no. 3, pp. 20-25. Berkhout, E. & Hoogeveen, R. (2016). ALARA in de praktijk: Zin en onzin van dosisbeperking. De Tandartspraktijk, vol 37, no. 8, pp. 31-37. DOI: 10.1007/s12496-016-0107-y Berkhout, W.E.R. (2016). Handheld röntgentoestellen. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 11, no. 5, pp. 23-26. Berkhout, W.E.R. & de Lange, J. (2016). Röntgenraadsels. Reden tot ongerustheid? Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 11, no. 2, pp. 47. Berkhout, W.E.R. & de Lange, J. (2016). Röntgenraadsels. Anatomie of pathologie? Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 11, no. 4, pp. 51. Berkhout, W.E.R. & de Lange, J. (2016). Röntgenraadsels. Een Amerikaans verhaal. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 11, no. 6, pp. 53.

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Berkhout, W.E.R. (2016). Röntgenraadsels. Implantaat in beeld. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 12, no. 2, pp. 51-52. Bijl, D. & Baart, J. (2016). Geneesmiddelenbulletin. Nederlands Tandartsenblad. March 18;71(5):32. Bijl, D. & Baart, J. (2016). Geneesmiddelenbulletin. Nederlands Tandartsenblad. April 8;71(6):33. Bijl, D. & Baart, J.A. (2016). Geneesmiddelenbulletin. Nederlands Tandartsenblad. June 10;71(10):99. Bijl, D. & Baart, J. (2016). Geneesmiddelenbulletin. Nederlands Tandartsenblad. September 9;71(14):19. Bijl, D. & Baart, J.A. (2016). Geneesmiddelenbulletin. Nederlands Tandartsenblad. October 7;71(16):31. Bijl, D. & Baart, J. (2016). Geneesmiddelenbulletin. Nederlands Tandartsenblad. November 11;71(18):27. Carbaat, P.A.T. & Couturier, E.G.M. (2016). Hoofdpijn: classificatie en diagnose. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 11, pp. 539-544. DOI: 10.5177/ntvt.2016.11.16122 De Kok, P. (2016). Adhesief cementeren van porseleinen facings: Case report Kuraray Magazine. De Lange, J. (2016). De derde molaar in de onderkaak: Preventief verwijderen? Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, vol 9, no. 1, pp. 36-40. De Lange, J. (2016). Distractie van frontaal segment in de bovenkaak. [Bespreking van: C.U. Joss (2015) Distraction osteogenesis of the anterior mandibular process]. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 9, pp. 440. De Lange, J. (2016). Endodontische herbehandeling of apexresectie: is een evidencebased keuze mogelijk? Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 2, pp. 84-88. DOI: 10.5177/ntvt.2016.02.15147 De Lange, J. (2016). Overzicht van de ontwikkeling in de MKA-chirurgie. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, vol 9, no. 1, pp. 7-11. De Ruiter, M.H.T., Berkhout, E.W.R. & de Lange, J. (2016). Röntgenraadsels. Een pijnlijke zwelling in de omslagplooi in de bovenkaak. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 12, no. 1, pp. 51- 52. Disse, M.A. (2016). Schisis, een multidisciplinaire behandeling. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 12, no. 3, pp. 13-19. Donders, H.C.M., Berkhout, W.E.R. & de Lange, J. (2016). Röntgenraadsels. Solitaire of multiple radio- opaciteit? Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 11, no. 3, pp. 51. Dubois, L. & Roelofs, M.W.K. (2016). Tandletsel: de opvang en primaire behandeling. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, vol 9, no. 1, pp. 24-31. Forouzanfar, T. (2016). Eén op de vijf volwassen Europeanen lijdt aan chronische pijn. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 10, pp. 447. Gibbs, S. Bijna zoals een echte huid. Linkedin-ZonMw Showcase Translational Research: from bench to bedside. (2016). Web publication/site, Linkedin-ZonMw, Nederland. Hoekema, A., de Vries, N., Aarab, G., de Lange, J., Wetselaar, P. & Lobbezoo, F. (2016). Slaapapneu: Naslagwerk bij de online cursus. AccreDidact, Houten. Hoogeveen, R.C. (2016). Draagbare röntgentoestellen in de tandheelkunde. Imago, vol 4, pp. 52-54. Hoogeveen, R. (2016). Orthodontische röntgendiagnostiek. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 11, no. 5, pp. 27-34. Karssemakers, L.H.E., Baart, J.A., van Eijnatten, M., Wolff, J.E.H. & Forouzanfar, T. (2016). Radiologische aspecten van trauma in het aangezicht – Wat de clinicus van het radiologisch onderzoek verwacht. Imago, vol 6, pp. 48-51. Knibbe, W., Loyen, N.A., van der Meulen, M.J. & Lobbezoo, F. (2016). Diagnostische Criteria voor Temporomandibulaire Disfunctie: Onderzoeksinstrumenten. ACTA. Knibbe, W. (2016). Terughoudendheid gepast bij op het uiterlijk gerichte ingrepen. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, vol 8, no. 4, pp. 14-17. Lobbezoo, F., Aarab, G., Knibbe, W., Koutris, M., Warnsinck, C.J., Wetselaar, P. & Visscher, C.M. (2016). Pijnlijke temporomandibulaire disfuncties: diagnose en behandeling. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 11, pp. 528-532. DOI: 10.5177/ntvt.2016.11.15259 Middelkoop, E., Gardien, K.L.M., Brouwer, K.M., Waaijman, T., Uhlrich, M.M.W. & Gibbs, S. (2016). Resultado de las quemaduras tratadas mediante cultivo de células epidérmicas autólogas: reglamentos e implicaciones para ensayos clínicos internacionales con Productos de Terapia Avanzada. Heridas y Cicatrización, vol 6, no. 4, pp. 6-10. Oomens, M.A.E.M., Booij, L.H.D. & Baart, J.A. (2016). Algehele anesthesie bij jonge kinderen in de tandheelkunde. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 5, pp. 240-242. DOI: 10.5177/ntvt.2016.05.15258 Poorterman, J.H.G. (2016). Posterior 2016. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 4, pp. 177.

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Poorterman, J.H.G. & Berkhout, W.E.R. (2016). Richtlijnen in de radiologie. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 11, no. 5, pp. 8-13. Roelofs, M.W.K., Berkhout, W.E.R. & de Lange, J. (2016). Röntgenraadsels. Een radiologische toevalsbevinding. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 11, no. 5, pp. 51. Roeters, J. & van Calcar, N. (2016). Esthetische tandheelkunde met composiet en porselein. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, vol 8, no. 4, pp. 8-13. Scholtanus, J.D. (2016). Hora est 2. Is door amalgaam verkleurd dentine een geschikt substraat voor hechting van composiet? Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 6, pp. 313. DOI: 10.5177/ntvt.2016.06.16152 Schreurs, R. (2016). De virtuele patiënt: van 3D-diagnostiek naar intraoperatieve chirurgische guidance. Quality Practice. Nascholingstijdschrift voor Tandartsen, vol 11, no. 5, pp. 14-22. Tuinzing, D.B. (2016). Reconstructie van de orbita. [Bespreking van: L. Dubois (2016). Predictability in orbital reconstruction]. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 11, pp. 568. Van der Avoort, P.G.G.L. (2016). Onderhoud van implantaten. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, vol 8, no. 2, pp. 19-26. Van der Kaaij, N.C.W. & Zuurbier, P.C.M. (2016). Onzichtbare orthodontie: Vacuümgevormde apparatuur, linguale apparatuur en keramische brackets. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, vol 8, no. 4, pp. 23-28. Van der Sanden, W.J.M., Kreulen, C.M. & Berkhout, W.E.R. (2016). Scholing in de tandheelkundige radiologie. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 4, pp. 211. DOI: 10.5177/ntvt.2016.04.15222 Van der Stelt, P.F. (2016). Conebeamcomputertomografie: is meer ook beter? Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 4, pp. 189-198. DOI: 10.5177/ntvt.2016.04.15221 Van der Stelt, P.F. (2016). Lusten en lasten. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 4, pp. 171. Van der Stelt, P.F. (2016). Panoramische röntgenopnamen in de tandheelkundige diagnostiek. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 4, pp. 181-187. DOI: 10.5177/ntvt.2016.04.15208 Van der Weijden, F. & Berkhout, E. (2016). De gerechtvaardigde röntgenfoto. Dentista: magazine voor het tandheelkundig team, vol 13, pp. 13-15. Van der Zande, M.M., Gorter, R.C., & van der Heijden, G.J.M.G. (2016). Vernieuwingen in de praktijk. Rubriek Uitgelezen Nederlands Tandartsenblad, vol 71, no. 14, pp. 18. Van Waas, M.A.J. (2016). Klinische gevolgen als de positie van het implantaat verandert. [Bespreking van: P.J.A. van Eekeren (2016). Clinical consequences when changing the position of the implant-abutment interface]. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 11, pp. 567. Verweij, J.P., Anssari Moin, D., Mensink, D., Wismeijer, D. & van Merkesteyn, J.P.R. (2016). Autotransplantatie 2.0. Overwegingen, uitkomsten en nieuwste technieken. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 7/8, pp. 348-353. DOI: 10.5177/ntvt.2016.07/08.16119 Wes, J.T., Houppermans, P.N.W.J., Verweij, J.P., Mensink, G., Liberton, N. & van Merkesteyn, J.P.R. (2016). De 3D-geprinte boormal voor de bilaterale sagittale splijtingsosteotomie. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 9, pp. 400-404. DOI: 10.5177/ntvt.2016.09.16142 Wetselaar, P. (2016). Hora est 6. Het Gebitsslijtage Beoordelingssysteem: ontwikkeling en toepassingen. Nederlands Tijdschrift voor Tandheelkunde, vol 123, no. 10, pp. 492-494. DOI: 10.5177/ntvt.2016.10.16184

Grants: current projects with external funding Aarab, G. The role of race in the pathogenesis of obstructive sleep apnea: Asians versus Caucasians. KNAW Project Grant, China Exchange Programme: granted €26.700,-. (2016, January 01 - 2018, December 31). Aarab, G. A study to the effects of oral appliance therapy on masseter muscle activity in obstructive sleep apnea patients: a randomized controlled trial. Research grant American Equilibration Society, granted €2.500,- (2014, January 01 - 2017, December 31). Aarab, G. A study to the effects of oral appliance therapy on masseter muscle activity in obstructive sleep apnea patients: a randomized controlled trial. Research grant Dutch Society of Gnathology and Prosthetic Dentistry, granted (€5.000,-), (2014, January 01 - 2018, December 31). Bakker A.D., Gibbs, S., Ioan-Facsinay, A., Mastbergen, S. & Brivio, M. A modular microfluidic Joint-on-a-Chip model for reliable in vitro modelling of the human joint for osteoarthritis research and drug development. Type of grant: NC3Rs CrackIT Phase 1. Finance: £100.000. Department of Oral Cell Biology ACTA, LUMC / UMCU / Micronit (2016, January 01 - 2017, January 01).

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Bakker, A.D., Gibbs, S., Monge, R. & Price, L. Bone-on-chip Analysis Platform for In Vitro Drug Performance Evaluation. Type of grant: EuroStars. Finance: €350.000 cash for ACTA (total project = €1,647,240.15 of which 50% is matching). Department of Oral Cell Biology ACTA, / BeOnChip Spain / Ocello BV NL.- Mrs. Rosa Monge / Leo Price. (January 01 2016, January 01 – 2019, January 01). Bakker, A.D. & Jaspers, R.T. Effects of osteocyte specific molecules on myoblasts. HORBONE II. Type of grant: 3e geldstroom, Friesland Campina. Finance: €49.051. Department of Oral Cell Biology ACTA, Fysiology VU. (January 01 2016, January 01 – 2017, January 01). Becking, A.G. & Kleverlaan, C.J. CRANIOSAFE: Optimized and innovative materials and customized treatment strategies for cranioplasty. NWO-STW, granted €750.000, (2016, January 01 - 2017, January 01). Benic, G.I., Wismeijer, D., Hassan, B., Tahmaseb, A. & Hämmerle, C.H.F. (2015). A multi-center study on ceramic implant restorations. ITI grant (together with Zurich), International Team of Implantologists grant number 1030_2014 total amount granted €160.000, (2014, January 01 - 2016, December 31). Chen, H. Use of Cone Beam Computerized Tomograph (CBCT) for the diagnosis of obstructive sleep apnea. PhD project financially supported by Grant China Scholarship Council (CSC), granted €26.700,00: (2013, October 01 - 2017, October 01). De Lange, J. Ongoing research in OSA. 4Dental project, granted €30.000: (2016, January 01 - 2016, December 31). De Lange, J., Lobbezoo, F. & de Vries, N. Reinforcing ACTA's focus on dental sleep medicine. SomnoMed Inc., granted €250.000 for 1 parttime AIO and 1 parttime UHD: (2016, January 01 - 2020, January 01). Den Heijer, M., Bisschop, P. & Bakker, A.D. Bone marrow adipocytes as mediator of postmenopausal bone loss. MOVE – VUmc PhD call 2016. Granted for 4 years: €150.000. Deng, D.M. & Wu, G. Application of a novel local antimicrobial delivery and osteoconductive system on decontaminated implant surfaces to promote re-osseointegration. ITI Foundation research grant, 1034_2014 (Principal investigator) (01-07-2015 till 30-06-2017), granted 37,798 Euro: (2015, July 01 - 2017, July 30). De Oliveira Gamba, T. Association of two craniometric methods for sexual prediction in CBCT scans. One year scholarship in the context of doctoral research of Mr. De Oliveira Gamba, financially supported by the Brazilian Coordination for the Improvement of Higher Education Personnel (CAPES; Process: 99999.010890/2014-09). Granted €22.780 (2015, July 1 – 2016,-July 1). Everts, V., van Lenthe, G.H., Koolstra, J.H. & Lobbezoo, F. Biomechanical changes in articulation of the jaw joint due to aging. EU MOVE project. Granted 3 years full time: (2014, October 01 - 2017, October 01). Fahlgren, A., Bakker, A.D. & Robinson, N. Proof-of-Concept Livsvetenskaper 2016, Vetenskapsrådet (Wetenschapsraad), Zweden. Granted €180.000 for 1 year (2016, December 01 - 2016, December 31). Feilzer, A.J. & Gibbs, S. Titanium implants and their emerging health problems: Development of a new accurate diagnostic test for titanium sensitivity in patients. Technology Foundation STW, granted €560.000: (2014, January 01 - 2018, January 01). Forouzanfar, T. Klinische validatie van SPG-stimulatie in chronische clusterhoofdpijnpatiënten met het ATI- neurostimulatiesysteem. Innovatiefonds zorgverzekeraars, granted € 300.000,-: (2013, December 01 - 2016, December 01). Jaspers, R.T. & Klein Nulend, J. European Union: MOVE-AGE Erasmus Mundus Joint Doctorate Program Prevention of mobility loss with ageing. PhD project Aging associated impairment of muscle mechanosensitivity causing reducted muscle protein synthesis and regeneration. Granted € 180.000: (2014, January 01 - 2017, January 01). Klein Nulend, J., Everts, V., Feilzer, A.J. & Kleverlaan, C.J. Research priority grant. University of Amsterdam, granted €1.650.000,-: (2012, January 01 - 2017, January 01). Klein Nulend, J., ten Bruggenkate, C.M., Schulten, E.A.J.M. & Helder, M.N. ITI grant: Blood vessel formation and bone regeneration potential of the stromal vascular fraction containing adipose stem cells seeded on calcium phosphate scaffolds for bone augmentation in the human maxillary sinus floor elevation model. International Team for Implantology (ITI), granted € 36.158,-: (2015, August 01 - 2016, February 01). Klein Nulend, J., Helder, M.N. & Amoabediny, G. Skeletal tissue production using regenerative medicine and adipose stem cell technology for large bone defects. University of Tehran – Research Center for New Technologies in Life Sciences Engineering - sponsored project, granted €200,000: (2013, January 01 - 2017, October 01). Lobbezoo, F. Associations between sleep bruxism and peri-implant complications: a follow-up study. Project Grant Sunstar Suisse S.A., granted €150.000,-: (2014, January 01 - 2017, December 31). Lobbezoo, F., de Lange, J., Hoekema, A. & de Vries, N. Apnea research. Somnomed, granted €337.500,-; (2016, January 31 – 2020, January 31).

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Lobbezoo, F., de Lange, J., Hoekema, A. & de Vries, N. Apnea research; NVTS; granted €25,000.-; (2016, January 31 – 2020, January 31). Lobbezoo, F., de Lange, J., Hoekema, A. & de Vries, N. Apnea research; NVvO; granted €25,000.-; (2016, January 31 – 2020, January 31). Lobbezoo, F., de Lange, J., Hoekema, A. & de Vries, N. Apnea research; BOOA; granted €32,500.-; (2016, January 31 – 2020, January 31). Marpaung, C.M., van Selms, M.K.A. & Lobbezoo, F. Prevalence and risk factors of temporomandibular disorders and bruxism in Indonesian children and adolescents – A pilot study; Trisakti University Grant; granted €2,750.-; (2015-2016). Marpaung, C.M., van Selms, M.K.A. & Lobbezoo, F. Prevalence and risk factors of temporomandibular disorders and bruxism in Indonesian children and adolescents; Gesere Foundation; granted €12,000.-; (2016-2017). Scherder, E.J.A., Weinstein, H., Lobbezoo, F. & Vlaar, A. Pain, cognition & motor behavior in Parkinson’s disease. Assessment and treatment by GP’s and Dentists; Stichting ParkinsonFonds; granted €209.094,-; (2016, January 1 –2021, December 31). Scherder, E.J.A. & Lobbezoo, F. Diagnostiek en behandeling van pijn bij mensen met een dementia die thuis wonen of in het verpleeghuis zijn opgenomen. F. Lobbezoo responsible for the dental part of this project which equals approx. 1/3 of the total amount granted €126.667,-: NutsOHRA, RCOAK, SBOH, Henriëtte Hofje as sources for the funding of three PhD projects (NutsOHRA €150.000,-; RCAOK €160.000,-; Henriëtte Hofje €40.000,-; Alzheimer Nederland €30.000,-; total = €380.000,- (2012, January 01 - 2017, December 31). Schulten, E.A.J.M. & Forouzanfar, T. Straumann-instrumentarium (granted €50.000,- in natura). (2015, January 01 - 2016, December 31). Van Eijnatten, M. Artificial intelligence in medical 3D printing, Young eScientist of the year award 2016, granted €50.000,- (of which € 40.000,- in kind in the form of an eScience engineer). (2016, January 01 - 2016, December 31). Van Eijnatten, M. Improving the accuracy of CBCT technology for applications in medical 3D printing. Planmeca Oy Finland, granted €64.796,- (2016, January 01 - 2016, December 31). Van Lenthe, G.H. & Klein Nulend, J. European Union: MOVE-AGE Erasmus Mundus Joint Doctorate Program Prevention of mobility loss with ageing. PhD project: Does the osteocyte lacuna affect bone adaptive response to aging? Granted for 3 years € 180.000: (2013, January 01 - 2017, January 01). Van Loon, J.J.W.A. ESA ESTEC Support Activities for TEC-MMG Gravity Research Lab; granted €100.000 yearly, (2016, January 01 - 2016, December 31). Van Loveren, C., van Strijp, A.J.P., Kleverlaan, C.J. & Feilzer, A.J. Infiltrating micro-sealant for preventive treatment of early non-cavitated caries (PEARL). Eurostars project 224 k€ (2016-2019). Wang, T. TOPPER project: Treatment of periodontal disease, prosthodontics evaluated by oral radiology. PhD program during 4 years, financially supported by Grant China Scholarship Council (CSC), granted €57.600,00: (2016, September 01 - 2020, November 01). Wierink, C. & Lobbezoo F. ZonMw, De mond niet vergeten! Granted €114.196,- (2016, March 31 – 2018, March 31). Wismeijer, D. This project aims to demonstrate a first-in-patient safety and clinical efficacy of BioCaP (- µconcentrations BMP2), a unique product for regenerative treatment of bone defects. ZonMw, granted €1033.509, (2014, January 01 - 2016, December 31). Wismeijer, D. Evaluating CAD CAM zirconium implant crowns. ITI Grant (together with Chris Evans (Sydney, AUS), granted €30.000, (2015, January 01- 2016, December 31). Wismeijer, D. Digital planning of one-piece Zirconia implants, does it influence the surgical, clinical and prosthodontic outcomes? A randomized clinical trial. ITI investigator initiated study, granted €136.226, (2015, January 01- 2016, December 31). Wismeijer, D. 3D printed restorations on dental implants. A clinical trial. TKI funding, granted €97.865, and €80.000, (2015, January 01- 2016, December 31). Wismeijer, D., Bruers, J.J.M. & Reijers, H. Data mining naar de kosten effectiviteit van implantaat gedragen overkappingsprotheses in bestanden van de zorgverzekeraars. NWO project. Granted €78.000, (2015, January 01- 2016, December 31). Wismeijer, D. & Tahmaseb, A. Evaluation of printed biomaterials in an animal model. Materials. Granted €15.000, in kind. (2015, January 01- 2016, December 31). Wolff, J.E.H. & Forouzanfar, T. 3D-technology. DSM Grant, granted 0,4 fte Phd student, Geleen, the Netherlands (2015, January 01 - 2016, December 31).

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Indicators of Esteem

Editorship book Wismeijer, D., Buser, D. & Chen, S. (2016). Biological and hardware complications in implant dentistry (Russian translation): ITI Treatment Guide Series, Volume 8, 1st edition, 232 pp. Authors: U. Brägger & L. Heitz- Mayfield, Quintessence Publishers, ISBN: 978-5-903567-29-4. Wismeijer, D., Chen, S. & Buser, D. (2016). Implant therapy in the geriatric patient (English): ITI Treatment Guide Series, Volume 9, 1st edition, 312 pp. Authors: F. Müller & S. Barter, Quintessence Publishers, ISBN: 978-3-86867-311-1.

Memberships editorial board Aarab, G.: Journal of Dental Sleep Medicine. Bakker, A.D.: Odontology. De Vries, N.: The Open Otorhinolaryngology Journal (TOOTORJ). Klein-Nulend, J.: Clinical Reviews in Bone and Mineral Metabolism. Klein-Nulend, J.: European Cells & Materials. Klein-Nulend, J.: Experimental and Clinical Endocrinology & Diabetes. Klein-Nulend, J.: Journal of Musculoskeletal Research. Klein-Nulend, J.: Stem Cells. Klein-Nulend, J.: The Open Biology Journal. Klein-Nulend, J.: The Open Nitric Oxide Journal. Klein-Nulend, J.: The Open Tissue Engineering and Regenerative Medicine Journal. Koolstra, J.H.: Applied Bionics and Biomechanics. Koolstra, J.H.: Journal of Dental Biomechanics. Lobbezoo, F.: Journal of Craniomandibular Function. Lobbezoo, F.: Journal of Dental Sleep Medicine. Lobbezoo, F.: Journal of Oral Rehabilitation. Lobbezoo, F.: Quality Practice. Nascholingstijdschrift voor Tandartsen. Poorterman, J.H.G.: Nederlands Tijdschrift voor Tandheelkunde. Sanderink, G.C.H.: Dentomaxillofacial Radiology. Sanderink, G.C.H.: Oral Radiology. Tahmaseb, A.: Forum Implantologicum. Van der Stelt, P.F.: Clinical Oral Implants Research. Van der Stelt, P.F.: Dentomaxillofacial Radiology. Van der Stelt, P.F.: Journal of Dentistry Shiraz University of Medical Sciences. Van der Stelt, P.F.: Odontology. Van Loon, J.J.W.A.: The Scientific World Journal. Van Loon, J.J.W.A.: Gravitational Physiology, Aging and Medicine. Van Loon, J.J.W.A.: Microgravity Science and Technology, MST (Springer Journal). Visscher, C.M.: Journal of Craniomandibular Function. Wu, G.: Austin Journal of Dentistry. Wu, G.: BioMed Research International, guest editor.

Scientific awards/honours Chen, H. (June 18, 2016). EADMFR Research award 2nd prize for best oral presentation: Reliability and accuracy of imaging software for three-dimensional analysis of the upper airway on cone beam CT. European Academy for DentoMaxilloFacial Radiology, Cardiff, UK. Fazaeli, S. (January 8, 2016). Bolk prijs, Nederlandse Anatomen Vereniging, Lunteren, the Netherlands. Van der Meer, H.A., Speksnijder, C.M., Engelbert, R., Lobbezoo, F., Nijhuis–van der Sanden, M.W.G. & Visscher, C.M. (April 14-16, 2016). Price for best poster at the American Academy of Orofacial Pain meeting, Orlando, USA.

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Van der Meer, H.A., Speksnijder, C.M., Engelbert, R., Lobbezoo, F., Nijhuis–van der Sanden, M.W.G. & Visscher, C.M. (April 23, 2016). Price for best poster at the Heads up! NVTM-symposium of the Dutch Association of Manual Therapists, Ede, the Netherlands. Zembic, A. (November 11, 2016). NVOI-prijs with article: Within-subject comparison of maxillary implant- supported overdentures with and without palatal coverage. Najaarscongres Nederlandse Vereniging voor Orale Implantologie (NVOI), Den Haag, the Netherlands.

Organization of (inter)national scientific congresses and symposia Bakker, A.D. (May 2-5, 2016). Organizer. ECTS PhD training course, Oxford UK. Bakker, A.D. (November 8 – 9, 2016). Organizer. 26e Najaarsvergadering Nederlandse Vereniging voor Calcium en Botstofwisseling, Zeist, NL. Chen, H. (April 8-12, 2016). Organizer. Multidiscipline treatment in obstructive sleep apnea. Faculty of Dentistry, Shandong University, Jinan, China. De Vries, N. (May 20, 2016). Organizing committee. Implementation of innovation in the treatment of OSA. Amsterdam, the Netherlands. De Vries, N. (August 13-15, 2016). Organizing committee of EUROSAS2016, Rimini, Italy. Forouzanfar, T. (October 20-21, 2016). Organizer. 3D Printing in Healthcare Conference, Amsterdam, the Netherlands. Jorgensen, C. & Forouzanfar, T. (October 6-9 ,2016). Organizers. CELLS / Musculoskeletal conference. Amsterdam, the Netherlands. Klein-Nulend, J., Jaspers, R.T., Bravenboer, N. & Bakker, A.D. (2016 - 2017). Organizers. AMS (Amsterdam Movement Sciences) Mechanobiology meetings RaMBaM: Regeneration and Mechanobiology of Bone and Muscle. Tahmaseb, A. (April 15-16, 2016). Chair and member of the scientific organization committee. ITI Congress Benelux, Expecting the unexpected: We tried everything but still. Maastricht, the Netherlands. Van Loon, J.J.W.A. (October 26, 2016). Organizer and chair symposium: Artificial Gravity. American Society for Gravitational and Space Research 32nd annual meeting / Symposium III: Artificial Gravity., Cleveland, OH, USA. Wismeijer, D. (April 15-16, 2016). Member of the scientific organization committee. ITI Congress Benelux, Expecting the unexpected: We tried everything but still. Maastricht, the Netherlands.

Invited speakers at (inter)national congresses or symposia Bakker, A.D. (May 16, 2016). Basic and translational science: Mechanotransduction in bone and muscle. European Calcified Tissue Society, Rome, Italy. De Vries, N. (April 15, 2016). Why does UPPP fail? International Society Sleep Surgery (ISSS), Sao Paulo, Brazil. De Vries, N. (August 13, 2016). Positional therapy. 23th congress of the European Sleep Research Society, Bologna, Italy. De Vries, N. (October 21-23, 2016). Hypoglossal nerve stimulation in OSA. Spanish ENT Meeting, Sevilla, Spain. De Vries, N. (November 3-4, 2016). Nieuwere therapieën bij OSAS: positietherapie & hypoglossus stimulatie, waar staan we nu? Slaap2016, Ermelo, the Netherlands. De Vries, N. (November 28-30, 2016). 1. General introduction to OSA and why we need alternative treatments. 2. Sleep studies: polysomnography and polygraphy, in hospital and home sleep testing. 3. Drug induced sleep endoscopy (DISE) and the VOTE system. 4. Standard ENT surgery for OSA. 5. Interactive DISE session (interpretation of a series of DISE videos, and translation of findings to treatment options). 6. Non-surgical OSA treatment: new generation positional therapy and multimodality treatment. 7. Upper airway stimulation. OSA Symposium OSA from a different angle for Otorhinolaryngology Residents, Kuwait Institute for Medical Specialization, Kuwait. De Vries, N. (December 17, 2016). OSA and bariatric surgery. ESPCOP bariatrie congress, Gent, Belgium. Fazaeli, S. (November 10, 2016). TMJ disc biomechanics - a structural-functional overview. Scientific meeting Zentrum für Zahnmedizin, Zurich. Forouzanfar, T. (October 8, 2016). Phase I/II trial of SVF for maxillary sinus floor one augmentation. CELLS / Musculoskeletal conference, Amsterdam, the Netherlands. Gibbs, S. (June 2, 2016). 1. Development of a battery of in vitro assays leading to increased efficiency in chemical safety testing. 2. Challenges related to animal-free testing and assessment of medical devices and biomaterials. IVTIP, Barcelona, Spain.

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Gibbs, S. (June 21, 2016). human Organ and Disease Model Technologies Towards precision medicine in future healthcare. CCA NEXT, VUmc, Amsterdam. Gibbs, S. (June 29, 2016. New developments in tissue engineered wound healing and scar models. TERMIS-EU. Uppsula, Sweden. Gibbs, S. (September 14, 2016). Focus on innovative skin models for safety testing. Liverpool University. Gibbs, S. (October 12, 2016). human Organ and Disease Model Technologies Towards precision medicine in future healthcare. Utrecht, NL. Gibbs, S. (October 26, 2016). New developments in tissue engineered wound healing and scar models. Gene2Skin congress, Porto, Portugal. Hoekema, A. (May 20, 2016). Bimaxillary osteotomy; only for severe OSA? Symposium OSA Revisited, Amsterdam, the Netherlands. Hoekema, A. (September 24, 2016). Round table: On the role of Maxillofacial Surgery in the treatment of OSA. iBEDSMA 2nd two-day symposium, Knokke, Belgium. Hoekema, A. (November 3-4, 2016). Wanneer osteotomie bij OSAS? Slaap2016, Ermelo, the Netherlands. Klein-Nulend, J. (August 17, 2016). Mechanotransduction in bone. Seminar at San Carlos University, Cebu City, Philippines. Klein-Nulend, J. (November 11-12, 2016). Mechanotransduction, mechanisms. Bone and Muscle – New Worlds 2016 Congress, Berlin, Germany. Koolstra, J.H. (January 9, 2016). Biomechanica van het kaakgewricht. 178ste Wetenschappelijke vergadering Nederlandse Anatomen Vereniging, Lunteren. Koolstra, J.H. (November 10, 2016). Finite element analysis of TMJ loading. Scientific meeting Zentrum für Zahnmedizin, Zurich. Koutris, M. (June 25, 2016). DC/TMD in postgraduate dental education. IADR meeting, Seoul, South Korea. Langenbach, G.E.J. (January 9, 2016). Het dagelijks gebruik van kauwspieren. 178ste Wetenschappelijke vergadering Nederlandse Anatomen Vereniging, Lunteren. Lobbezoo, F. (April 8, 2016). Systematic review on secondary symptoms of bruxism. A progress report. Academic Advisory Board Meeting Grindcare/Sunstar, Lijnden, the Netherlands. Lobbezoo, F. (April 15, 2016). Bruxisme ter preventie van OSAS: Luchtkauwerij? 8e NVTS-congres In het holst van de nacht, Nieuwegein. Lobbezoo, F. (April 22, 2016). Orofaciale pijn bij ouderen. Topics in de ouderengeneeskunde en ouderenzorg. Maastricht. Lobbezoo, F. (June 3-4, 2016). 1. Bruxism diagnosis and etiology. 2. Bruxism management and clinical consequences. 2nd Congresso Nazionale GSID Let’s chew on bruxism, Marina di Carrara, Italy. Lobbezoo, F. (November 4, 2016). Bruxisme. State-of-the-Art. Slaap2016, Ermelo, the Netherlands. Lobbezoo, F. (November 24, 2016). 1. Bruxism Part I: Definition, Diagnosis & D.D. 2. Bruxism Part II: Epidemiology & Etiology. 3. Bruxism Part III: Consequences. 4. Bruxism Part IV: Management. Finnish Dental Congress 2016, Helsinki, Finland. Lobbezoo, F. (November 28-30, 2016). The dental perspective on OSA and diabetes. OSA Symposium: OSA from a different angle for Otorhinolaryngology Residents, Kuwait Institute for Medical Specialization, Kuwait. Schulten, E.A.J.M. (March 18, 2016). Edentulous patients. Symposium VUmc, Straumann, Uden, NL. Schulten, E.A.J.M. (September 13, 2016). Edentulous patients, Symposium VUmc Straumann Zwolle, NL. Tahmaseb, A. (April 15-16, 2016). So now we have a guideline and then what? ITI Congress Benelux, Expecting the unexpected: We tried everything but still. Maastricht, the Netherlands. Tahmaseb, A. (November 10, 2016). Dynamic guided surgery. ITI congress, Istanbul, Turkey. Tahmaseb, A. (November 12-14, 2016). Small diameter implants. Straumann platinum congress, South Carolina, USA. Tahmaseb, A. (September 16, 2016). Computer guided implant surgery. International Maxillofacial congress, London, UK. Tahmaseb, A. (June 9-10, 2016). Congress, Alicante, Spain. Minimal Invasive bone augmentation. Thymi, M. (December 1, 2016). Associations between sleep bruxism and (peri-)implant complications. Update of an ongoing follow-up study. Academic Advisory Board Meeting Grindcare/Sunstar, Amsterdam, the Netherlands. Van der Stelt, P.F. (November 9-12, 2016). Justification of radiographs: more is not always better. 11th Asian Congress of Oral Maxillofacial Radiology, Chiang Mai, Thailand. Van Eijnatten, M. (January 27, 2016). The challenges of medical 3D printing. MedTech 3D Printing Conference, Brightlands, Maastricht.

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Van Eijnatten, M. (March 18, 2016). What 3D printer should I buy? Symposium Heart disease in 3D and 4D, LUmc, Leiden. Van Eijnatten, M. (November 3, 2016). UTE-MRI sequenties in de maxillofaciale chirurgie: een kadaverstudie.Ted talk NVMKA najaarsvergadering, Utrecht. Van Eijnatten, M. (November 23, 2016). 3D-printing in reconstructive surgery, the challenges of medical 3D printing. AMC symposium, Amsterdam. Van Eijnatten, M. (December 9, 2016). 3D scanning in the clinical field: technologies and applications, Drugs for Neglected Disease initiative. WHO, Genève (Sw). Van Loon, J.J.W.A. (February 12, 2016). Partial gravity analogs; large radius centrifuge(s). International Roadmap for Artificial Gravity Research Workshop during 2016 NASA Human Research Program Investigator Workshop, Galveston, TX, USA. Van Loon, J.J.W.A. (February 23, 2016). 1. Non-human experimentation in space. 2. Large human centrifuge initiative. Master course Human and Aerospace Physiological Sciences, Division of Applied Biomedical Research, Department of Physiology, King’s College, London, United Kingdom. Van Loon, J.J.W.A. (March 4, 2016). Key research at ESA Large Diameter Centrifuge (LDC) & Life Science Labs. ESA Advanced Concepts Team Science. Van Loon, J.J.W.A. (March 7-11, 2016). Gravity in life and physical sciences. United Nations/Costa Rica Workshop on Human Space Technology. San José, Costa Rica. Van Loon, J.J.W.A. (March 15, 2016). 1. Life- and Physical Science Instrumentation Laboratory (LIS). 2. Life science at different g levels (biology). @ ESA-ESTEC, Noordwijk, NL. ESA Experiment Hands-on Programmes Training Week. Redu, Belgium. Van Loon, J.J.W.A. (May 17, 2016). Gravity related research capability of ground-based facilities. Life and Physical Sciences. Workshop: Materials in the Space Environment, ASI, Rome, Italy. Van Loon, J.J.W.A. (June 28, 2016). Gravity machines and animal models. ESA-ELGRA Gravity-Related Research Summer School. Redu, Belgium. Van Loon, J.J.W.A. (November 24, 2016). Sensing changes of the gravitational load (from cells to organisms and beyond). VU-University, master course Extreme Biology, Amsterdam, NL. Visscher, C.M. (April 14-17, 2016). Lunch & Learn Session: TMD Case Presentations and Panel Discussion. American Academy of Orofacial Pain (AAOP) 40th scientific meeting, Lake Buena Vista, Florida, USA. Wetselaar, P. (November 25, 2016). The Tooth Wear Evaluation System (TWES), a clinical guideline for diagnosing and managing of tooth wear patients. Annual Congress, Association Dentaire Française (ADF), Paris. Wismeijer, D. (March 10, 2016). Digital workflow in dentistry, Where are we and where are we going. Keynote speaker. 33rd Interdisciplinary Dental Conference Rasmushof, KitzBuhl. Wismeijer, D. (April 15-16, 2016). So now we have a guideline and then what? ITI Congress Benelux, Expecting the unexpected: We tried everything but still. Maastricht, the Netherlands. Wismeijer, D. (October 20, 2016). 3D printing in Healthcare, A game changer. Conference Amsterdam. 3D printing in Healthcare. Wismeijer, D. (November 12, 2016). System overview and development. Presentation and live surgery. Root Analogue Implant REPLICATE™ Tooth Congress. ACTA, Amsterdam, the Netherlands. Wismeijer, D. (December 3-4, 2016). Digital tools in implant dentistry. Will they make our lives easier? Keynote speaker, ITI congress Beijing, China. Wolff, J.E.H. (January 26, 2016). Fracture-driven design. 3D printing materials conference, Brightlands, Maastricht. Wolff, J.E.H. (March 18, 2016). Edentulous patients. Symposium VUmc, Straumann, Uden, NL. Wolff, J.E.H. (April 14, 2016). The future of medicine, HP/Microsoft, Amsterdam. Wolff, J.E.H. (September 13, 2016). Edentulous patients, Symposium VUmc Straumann Zwolle, NL. Wolff, J.E.H. (October 7, 2016). Towards a new generation of craniofacial reconstructions: 3d-printing combined with cellular therapy. Cells conference on regenerative medicine, Amsterdam.

Other (inter)national scientific functions Aarab, G.: Member research committee American Academy of Dental Sleep Medicine (AADSM), since 2012. Aarab, G.: Member research committee Dutch Society of Dental Sleep Medicine (NVTS), since 2012.

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Baggen, J.H.M.: Member research committee, Nederlandse Vereniging Tandheelkundige Slaapgeneeskunde (NVTS), since 2016 Bakker, A.D.: Secretary Dutch Society for Calcium and Bone Metabolism. Bakker, A.D.: Leader Education committee European Calcified Tissue Society (ECTS). Bakker, A.D.: Board member European Calcified Tissue Society (ECTS). Berkhout, W.E.R.: Member Central Council European Academy of Dento-Maxillo-Facial Radiology (EADMFR). Berkhout, W.E.R.: Chairman Selection Criteria and Radiation Protection Committee European Academy of Dento-Maxillo-Facial Radiology (EADMFR). De Vries N.: Member of the Medische Advies Raad ApneuVereniging, since 2012. De Vries N.: Member of the Medical Advisory Board NightBalance, since 2014. De Vries N.: Member of the Medical Advisory Board Recent, since 2013. De Vries N.: Consultant for Philips Health care, since 2014. De Vries N.: Consultant for Olympus, since 2014. De Vries N.: Consultant for AE Mann Foundation, since 2016. Gibbs, S.: Member European Research Group for Experimental Contact Dermatitis (ERGECD). Gibbs, S.: Directory board member MOVE Research Institute & VU University, Amsterdam, the Netherlands. Gibbs, S.: Project jury member NC3Rs, London, UK. Gibbs, S.: Scientific expert advisor DEBRA trust. Hoekema, A.: President Nederlandse Vereniging voor Tandheelkundige Slaapgeneeskunde (NVTS), since 2008. Hoekema, A.: Member research committee, American Academy for Dental Sleep Medicine (AADSM), since 2009. Hoekema, A.: Member steering committee, Oral Appliance Network for Global Effectiveness (ORANGE Registry), since 2012. Hoekema, A.: Member steering committee, OSAS richtlijn, Kennisinstituut Medisch specialisten, Utrecht, the Netherlands, since 2015. Klein-Nulend, J.: Board member American society for Bone and Mineral Research (ASBMR) Women in Bone and Mineral Research Committee, USA, 2015- 2018. Klein-Nulend, J.: Member scientific board Department of Regenerative Medicine, Research Centre for New Technologies in Life Science Engineering, University of Tehran, Iran. Klein-Nulend, J.: External professor San Carlos University, Dept. of Physics, Cebu City, Philippines. Klein-Nulend, J.: Outer board member Irish Research Council Postdoctoral International Assessment 2015 (Fellowships in Science, Engineering and Technology), Royal Irish Academy. Koutris, M.: Secretary/Treasurer International RDC/TMD Consortium Network, IADR (2016-2018). Koutris, M.: Council Member (Greek National Representative), European Academy of Craniomandibular Disorders (EACD) (2016-2018). Kramer, G.J.C.: Voorzitter Wetenschap- en accreditatiecommissie NVvO. Kuitert, R.B.: Lid Richtlijnencommissie NVvO Lobbezoo, F.: Past President International RDC/TMD Consortium Network, IADR (2016-2018). Lobbezoo, F. Senior member Society of Oral Physiology (Store Kro Club), since 2015. Lobbezoo, F. Chair Nederlandsch Tandheelkundig Genootschap (NTG) [Dutch Dental Society], since 2016. Prahl, C.: Lid bestuur NVOS. Sanderink, G.C.H.: Member Trust Fund International Association of DentoMaxilloFacial Radiology. Schulten, E.A.J.M.: Fellow International Team for Implantology (ITI), Basel, Switzerland. Van Loon, J.J.W.A.: Expert reviewer for the European Commission Horizon 2020 space project EDEN-ISS part of the International Space Station portfolio

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(COMPET-7-2014 and COMPET-4-2015) in the space work programme. April-May 2016. Van Loon, J.J.W.A.: Vote-selected member, governing board member, American Society for Gravitational and Space Biology (ASGSB), for period 2015-2018. Van Loon, J.J.W.A.: External examiner Limerick Institute of Technology, Ireland. MSc. thesis Adam Shinner entitled: Microgravity induced phytohormones, September 2016. Van Loon, J.J.W.A.: User committee member for STW-project A lab-on-a-chip device to screen for the effect of mechanical signals on cells from dr.ir. Jeroen Rouwkema, Twente University, Enschede, NL. Van Loon, J.J.W.A.: Member European Science Foundation (ESF) College of Expert Reviewers, 2016-2019. Van Loon, J.J.W.A.: Member review board ESA Spin-Your-Thesis educational program for 2017 experiments. Van Loon, J.J.W.A.: Expert project reviewer for the European Commission Horizon 2020 space project BIOWYSE part of the International Space Station portfolio (COMPET-7-2014 and COMPET-4-2015) in the space work programme November-December 2016. Van Loon, J.J.W.A.: Chairperson Working Group 1: Space and Micro-Gravity Science (SMS). United Nations/Costa Rica Workshop on Human Space Technology. San José, Costa Rica, 7-11 March 2016. Van Loon, J.J.W.A.: Co-chairing J. van Loon & A. Solignac, session 11: Space Analogues (Part II) at the 37th Annual International Gravitational Physiology Meeting and the 14th European Life Sciences Symposium, Toulouse, France, 5-10 June 2016. Van Westing, K.: Lid richtlijnencommissie NVvO. Visscher, C.M.: Chair of the Data Management committee of the International RDC- TMD Consortium Network, since 2016. Wismeijer, D. External examiner for the MSc Curriculum Implant Dentistry University of Hongkong (2014-2017). Wismeijer, D. Visiting professor of the University of Belgrado Dental School. Wu, G.: Visiting professor in Guangzhou Medical University, China. Wu, G.: Visiting professor in Wenzhou Medical University, China.

Supervisor of an external PhD student De Vries, N. (2016). Supervisor of external PhD student Faiza Safiruddin with thesis: The role of drug induced sleep endoscopy as a selection tool in the treatment of obstructive sleep apnea. University of Antwerp, (co)supervisors: N. de Vries, O.M. VanderVeken, P.H. Weijning & C.A.B. Weijsers. Van Loon, J.J.W.A. (April 12, 2016). Co-supervisor of external PhD student D. Vorselen with thesis: Vesicle mechanics: a push into the nanoscale. Supervisor: prof.dr.ir. G. Wuite, VU-University, 2nd co-supervisor: dr. W. Roos, Amsterdam.

Collaborations - A. Gefen, Tel Aviv University, Israel, E. Corsini, Università degli Studi di Milano, Milan, Italy. - AMC, dr. P. Kloen (Dept Orthopaed Traumatol), Non-unions. - AMC, prof.dr.ir. T.H. Smit (Dept. of Med Biol), Biomechanical and biophysical aspects of bone regeneration. - Amsterdam University of Applied Sciences, prof.dr. R. Engelbert, Amsterdam, the Netherlands. - Ankara University, Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Ankara, Turkey. Prof. K. Kamburoglu. - Department of Oral and Maxillofacial Surgery, University of Torino, Italy. - Department of Orthopedics, VUmc. - Department of Radiology, University of Helsinky, Finland. - E. Roggen, 3Rs Management and Consultancy, Denmark.

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- Ege University, Faculty of Medicine, Center for Brain Research & Department of Physiology, prof.dr. K. Türker, Bornova, Izmir, Turkey. - Hacettepe University, Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Ankara, Turkey. Prof. N. Avcu. - Harvard University, Boston, MA, USA, dr. Ramaswami Krishnan (Dept. of Mechanical Engineering): Osteocyte mechanosensing. - Katholieke Universiteit Leuven, Leuven, Belgium, prof.dr. Frank P. Luyten (Dept. of Rheumatology,Skeletal Biology & Engineering Research Center, Prometheus, Division of Tissue Engineering): Systemic inflammation and generalized osteoporosis. - Katholieke Universiteit Leuven, Leuven, Belgium, prof.dr. Harry van Lenthe (Dept. of Biomechanical Engineering): Quantitative analysis of mechanical loading on osteocyte function. - Katholieke Universiteit Leuven, Leuven, Belgium, prof.dr. Louise Deldique (Dept. of Exercise Physiology): Muscle and bone anabolic resistance in aging (ER stress). - Kyushu University, Kyushu, Japan, prof.dr. Daisuke Mizuno (Dept. of Physics): Macro and microrheology of stem cells. - Leiden University Medical Center (LUMC), Department of Public Health and Primary Care (PHEG), prof.dr. W.P. Achterberg, Leiden, Netherlands. - New York University Dental College, prof.dr. K.G. Raphael, New York, NY, USA. - Newcastle University, Centre for Oral Health Research & Institute of Health and Society, Newcastle-upon- Tyne Hospitals' NHS Foundation Trust, dr. J. Durham, Newcastle-upon-Tyne, UK. - Okayama University, Okayama, Japan, prof.dr. Hiroshi Kamioka (Dept. of Orthodontics): Osteocyte imaging and mechanosensing. - R. Monge, BeOnChip Spain (Eurostars). - Radboudumc, IQ-healthcare, prof.dr. R. Nijhuis, Nijmegen, the Netherlands. - RUG, prof.dr. G. Raghoebar, dr. J. Schortinghuis (Dept. of Oral Maxillofac Surg), Jaw bone regeneration. - San Carlos University, Cebu City, Philippines, prof.dr. Rommel G. Bacabac, (Dept. of Physics, Biomedical Physics Group): Biophysics bone adaptation and regeneration. - School of interdisciplinary dentistry, Vienna medical faculty, Austria. - Shandong University, Department of Orthodontics, Faculty of Dentistry, Jinan, China, prof. Jing Guo. - Slotervaart General Hospital, Department of Clinical Neurophysiology and Brain Mapping Laboratory, dr. H.L. Hamburger, Amsterdam, the Netherlands. - Spaarne Hospital Hoofddorp, dr. Peter A. Nolte (Dept Orthopaedics): Low intensity pulsed ultrasound/micromechanical stimulation of bone. - State University of Campinas, Piracicaba Dental School, Piracicaba, Brazil, prof. M. Lima de Oliveira and prof. S.M. Almeida Boscolo. - TNO Life Style - Behavioral and Societal Sciences, dr. E. Vermaire and dr. A. Schuller, Leiden, the Netherlands. - University at Buffalo, Department of Oral Diagnostic Sciences, dr. R. Ohrbach, Buffalo (NY), USA. - University College of Dentistry, Department of Biomedical Sciences, dr. E. Schneiderman, Dallas, Texas, United States of America. - University Estadual Paulista (UNESP), Department of Dental Materials and Prosthodontics, prof.dr. Daniela Aparecida de Godoi Gonçalves, Araraquara School of Dentistry, Araraquara, Brazil. - University Medical Center (UMC) Utrecht, dr. CM Speksnijder, Utrecht, the Netherlands. - University of Aarhus, Department of Orofacial Pain and Jaw Function, prof.dr. Peter Svensson, Aarhus, Denmark. - University of Adelaide, School of Dentistry, prof.dr. G.C. Townsend, Adelaide, Australia. - University of Antwerp, Faculty of Medicine and Health Sciences, Department of Rehabilitation Sciences and Physiotherapy, dr. Willem de Hertogh, Antwerp, Belgium. - University of Athens, Orofacial Pain Clinic, Dental School, National and Kapodistrian, dr. Michail Tzakis, Emeritus prof. Vyron Droukas, Athens, Greece. - University of Gothenburg , Institute of Odontology, Department of Behavioral and Community Dentistry, Sweden., dr. M. Hakeberg & dr. G. Jonasson. - University of Helsinki, Department of Stomatognathic Physiology & Prosthetic Dentistry, dr. J. Ahlberg, Helsinki, Finland. - University of Linjöping, Linjöping, Sweden, dr. Anna Fahlgren (Dept Orthopaedics): Bone implant loosening. - University of Linjöping, Linjöping, Sweden, dr. Edwin de Jager (Biosensors and Bioelectronics Centre): Osteocyte mechanotransduction and polymer microactuators.

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- University of Montreal. Faculty of Dentistry, prof.dr. Gilles Lavigne, Montreal, PQ, Canada. - University of Naples Federico II, Department of Neurosciences, Reproductive and Oral Sciences, Section of Orthodontics and Temporomandibular Disorders, prof.dr. A. Michelotti, Naples, Italy. - University of Padova, TMD Clinic, prof.dr. D. Manfredini, Padova, Italy. - University of Tehran, Tehran, Iran: prof.dr. Ghassem Amoabediny (Research Center for New Technologies in Life Science Engineering / Biochemical, Biomedical, and Nanobio Engineering): Tissue engineering. - University of Tel Aviv, Department of Oral Rehabilitation, The Maurice and Gabriela Goldschleger School of Dental Medicine, prof.dr. Efraim Winocur, Tel Aviv, Israel. - University of Umea, Faculty of Medicine, Department of Clinical Oral Physiology, prof.dr. A. Wännman, Umea, Sweden. - Vrije Universiteit, Department of Clinical Neuropsychology, prof.dr. E.J.A. Scherder, Amsterdam, the Netherlands. - Vrije Universiteit, Nederlands Tweelingen Register (NTR), prof.dr. D.I. Boomsma, Amsterdam, the Netherlands. - VU University Medical Center Amsterdam, Department of General Practice & Elderly Care Medicine, prof.dr. C.M.P.M. Hertogh, Amsterdam, the Netherlands. - VU University Medical Centre Amsterdam, Department of Anesthesiology, EMGO+ Institute for Health and Care Research, prof.dr. R.S. Perez, Amsterdam, the Netherlands. - VU, dr. R.T. Jaspers (Dept. of Myology, Amsterdam Movement Sciences, Fac Behavioural & Movement Sciences): Bone – muscle interactions, mechanobiology. - VU, prof.dr.ir. Erwin J.G. Peterman (Dept. of Physics): Biophysics. Physics of living systems. - VUmc, dr. Marco N. Helder (Dept. of Oral & Maxillofacial Surgery), Basic science and clinical application of adipose stem cells. - VUmc, dr. N. Bravenboer (Dept. of Clin Chem), Systemic inflammation, bone adaptation and regeneration. - VUmc, prof.dr. Tim Forouzanfar, prof.dr. Bert A.J.M. Schulten, prof.dr. Chris M. ten Bruggenkate (Dept. of Oral Maxillofacial Surgery). Large bone defect reconstruction; Stem cell application for jaw bone augmentation. - VUmc, prof.dr. Willem F. Lems (Rheumatology), Systemic inflammation and bone biology.

Current PhD projects Abdel Aziz MFA. Diagnostic and therapeutic methods for small caries lesions in micro-invasive dentistry. Supervisors: prof.dr. A.J. Feilzer & prof.dr. I. Krejci, start: 2014. Alharbi, NM. Printing dental restorations. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. R. Osman, start: 2013 end 2017. Anssari Moin, D. New dimensions in tooth implant and transplantation. Supervisor: prof.dr. D. Wismeijer & prof.dr. J.P.R. Merkesteyn; co-supervisor: dr. B. Hassan, start: 2012 end 2017. Asikainen PJ. Implantology. Supervisors: prof.dr. C.M. ten Bruggenkate & prof.dr. E.A.J.M. Schulten, start 2011 end 2017. Baggen JHM. Neuropathic pain and TMD pain. Supervisor: prof.dr. F. Lobbezoo; co-supervisors: dr. M. Koutris & dr. C.M. Visscher, start: 2014. Bastidas Coral AP. Osteogenic differentiation of mesenchymal stem cells by bioactive molecules and mechanical loading in a 3D environment: Implications for craniomaxillofacial bone defects. Supervisors: prof.dr. J. Klein-Nulend & prof.dr. T. Forouzanfar; co-supervisors: prof.dr. C.J. Kleverlaan & dr. A.D. Bakker, start: December 2013. Beerens MW. Treatment of incipient white spot lesions. Supervisor: prof.dr. J.M. ten Cate; co-supervisor: dr.ir. M.H. van der Veen, start: 2009. Benoist L. Supervisors: prof.dr.N. de Vries & prof.dr. J. de Lange; co-supervisors: dr. P. van Maanen & dr. M. Ravesloot. Betti BF. Effects of bruxism-like mechanical loading of TMJ cartilage of pigs. Supervisors: prof.dr. F. Lobbezoo & prof.dr. V. Everts; co-supervisors: dr. A.D. Bakker & dr. G.E.J. Langenbach, start: 2014. Boffano P. Mandibular trauma: epidemiology, management and imaging. Supervisors: prof.dr. T Forouzanfar & prof.dr. E.A.J.M. Schulten; start 2011, end 2016. Boink MA. Novel saliva-derived peptides for state-of-the-art clinical wound-healing applications. Supervisors: prof.dr. S. Gibbs & prof.dr. E.C.I. Veerman, co-supervisor: dr. J.G.M. Bolscher, start: November 2010 end 2017.

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Bouwman WF. Sinus floor elevation with bone and bone substitutes. Supervisors: prof.dr. C.M. ten Bruggenkate & prof.dr. E.A.J.M. Schulten; co-supervisor: dr. N. Bravenboer, start 2011. Bozia M. Taakherschikking in de mondzorg. Supervisors: prof. dr. G.A. van der Weijden; co-supervisor: dr. W.E.R. Berkhout & dr. D.E. Slot. Start: September 2016. Buskermolen JK. Tissue engineering gingiva for in vitro assays and safety assessment of dental materials. Supervisors: prof.dr. S. Gibbs & prof.dr. C.J. Kleverlaan; co-supervisor: dr. A.D. Bakker, start: June 2013. Cao Y. Different osteoclasts and their response to cytokines. Supervisor: prof.dr. V. Everts, co-supervisors: dr.ir. T.J. de Vries & dr. I.D.C. Jansen, start: 2014 end 2017. Chalil S. Understanding muscle and bone anabolic resistance in ageing: is ER stress involved? Supervisors: prof.dr. P. Hespel, prof.dr. L. Deldicque & prof.dr. J. Klein-Nulend; co-supervisors: dr. A.D. Bakker & dr. R. Manders, start: 2012. Chen H. Anatomical characteristics of sleep apnea patients. Supervisors: prof.dr. P.F. van der Stelt, prof.dr. F. Lobbezoo & prof.dr. J. de Lange; co-supervisor: dr. G. Aarab, start: November 2013 end 2017. Couturier EG. Neurostimulation of cluster headache. Supervisor: prof.dr. T. Forouzanfar, start: 2015. Daher R. Optimizing the restoration of endodontically treated posterior teeth. Supervisors: prof.dr. A.J. Feilzer & prof.dr. I. Krejci, start: 2014. De Graaf NPJ. Development of a new accurate diagnostic test for titanium sensitivity in patients. Supervisors: prof.dr. A.J. Feilzer, prof.dr. T. Rustemeyer & prof.dr. S. Gibbs; co-supervisors: & prof.dr. C.J. Kleverlaan, start: 2014. De Jong T. Tissue engineering of the periodontal ligament. Supervisor: prof.dr.ir. T.H. Smit; co-supervisor: dr. A.D. Bakker, start: November 2012 end 2017. De Ruiter MHT. Surgical treatment options for OSAS. Supervisors: prof.dr. J. de Lange; co-supervisor: prof.dr. N. de Vries, start: October 2012. De Vries MW. The association between artritis and oral tissues. Supervisors: prof.dr. F. Lobbezoo & prof.dr. D. van Schaardenburg; co-supervisors: prof.dr. B.G. Loos & prof.dr. W. Crielaard; daily supervision: dr. C.M. Visscher, 1st, start: 2015 (PhD-student stopped in June 2016, Kroese wil take over the position in March 2017; dr. C.M.C. Volgenant will join the team as daily supervisor). Delwel S. Oral health & orofacial pain in dementia. Supervisors: prof.dr. F. Lobbezoo & prof.dr. C.M.P.H. Hertogh; co-supervisors: prof.dr. E.J.A. Scherder & dr. R.S.G.M. Perez, start: 2012. Derksen, WDC. The full digital workflow in implantology. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. A. Tahmaseb, start: 2012 end 2017. Dubois L. Unilateral condylar hyperplasia. Supervisors: prof.dr. A.G. Becking & prof.dr. J. de Lange, co- supervisor: dr. P.G. Raijmakers, start: September 2011, end: 2016. Evans, C. Zirconia crowns and bridges on implants. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. A. Tahmaseb, start: 2014 end 2018. Flügge, TV. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. A. Tahmaseb, start: 2015. Huang, H. Clinical stability of dental implants and experimental modulation of osteogenetic and inflammatory responses of collagen carriers. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. G. Wu, start: November 2013. Fazaeli S. Structure and function of the temporomandibular disk: new challenges for tissue engineering. Supervisors: prof.dr. V. Everts & prof.dr.ir. T.H. Smit; co-supervisor: dr.ir. J.H. Koolstra, start: 2011. Göbel JC. Combined therapy options for OSA patients. Supervisors: prof.dr. J. de Lange & prof.dr. N. de Vries; co-supervisor: dr. A. Hoekema, start: 2015. Gregor L. Low shrinkage dental composites. Supervisors: prof.dr A.J. Feilzer & prof.dr. I. Krejci, start: September 2008 end 2017. Heidsieck DSP. Management of obstructive sleep apnea in edentulous patients. Supervisors: prof.dr. J. de Lange & prof.dr. N. de Vries, start: April 2015. Hemmatian H. Does the osteocyte lacuna affect bone adaptive response to aging? Supervisors: prof.dr.ir. G.H. van Lenthe & prof.dr. J. Klein-Nulend; co-supervisor: dr. A.D. Bakker, start: November 2015. Ho BV. Effectiveness of the implementation project Don’t forget the mouth! – maintaining and improving oral health and general health of community dwelling elderly persons suffering from dementia. Supervisors: prof.dr. F. Lobbezoo & prof.dr. E.J.A. Scherder; co-supervisors: dr. C. Wierink & dr. G.J. van der Putten. Daily supervisor: dr. R.A.F. Weijenberg, start: April 2016. Hoogeveen RC. Dose reduction in orthodontic radiography. Supervisor: prof.dr. P.F. van der Stelt; co- supervisors: dr. G.C.H. Sanderink & dr. W.E.R. Berkhout, start: 2012, end: 2016. Houwing MH. Augmentation in oral implant surgery. Supervisors: prof.dr. C.M. ten Bruggenkate & prof.dr. E.A.J.M. Schulten, start 2014.

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Jalali R. The regulation of pH by ameloblasts during enamel mineralization. Supervisor: prof.dr. V. Everts, co- supervisors: dr. A.L.J.J. Bronckers & dr. B. Zandieh-Doulabi, start: September 2012, end 2017. Karssemakers LHE. PET en SPEC scans in orofacial surgery. Supervisors: prof.dr. D.B. Tuinzing & prof.dr. A.G. Becking, start: 2009. Kelder CL. BIOPRINT – Generation of bioactive patient-specific bone construct by 3D bioprinting. Supervisors: prof.dr. D. Wismeijer & prof.dr. J. Klein Nulend, start: October 2016. Kommers SC. Etiology and treatment of malocclusion after trauma. Supervisor: prof.dr. T. Forouzanfar; co- supervisor: dr.ir. J.h. Koolstra, start: 2011, end 2016. Kuik K. Surgical results of MMO procedures in OSA patients. Supervisor: prof.dr. J. de Lange; co-supervisor: dr A. Hoekema, start: September 2016. Lin, X. Biomimetic techniques and applied methodologies in bone and tissue engineering. Supervisors: prof.dr. D. Wismeijer & prof.dr. Q. Hu; co-supervisor: dr. Y. Liu, start: 2012, end 2017. Liu, Y. Signaling pathways accounting for the significantly higher efficiency of heterodimeric BMP. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. G. Wu, start: October 2015. Marpaung CD. Temporomandibular disorders and bruxism in children and adolescents. Supervisor: prof.dr. F. Lobbezoo; co-supervisor: dr. M.K.A. van Selms, start: 2013. Mirahmadi F. Biomechanical changes in articulation of the jaw joint due to aging. Supervisors: prof.dr. V. Everts & prof.dr. H. van Lenthe; co-supervisors: dr.ir. J.H. Koolstra & prof.dr. F. Lobbezoo. Start: 2014. Mokhtari-Jafari F. Simulation of bone cell growth in 3D scaffolds for optimization of bone formation in a bioreactor. Supervisors: prof.dr.ir. G. Amoabediny (University of Tehran, Iran) & prof.dr. J. Klein-Nulend; co-supervisors: dr. B. Zandieh Doulabi & dr. M.N. Helder (Orthopaedics, Vumc), start: December 2014. Muzalev KS. The relation between the type of bruxism & temporomandibular disorders. Supervisor: prof.dr. F. Lobbezoo; co-supervisors: dr. C.M. Visscher & dr. M. Koutris, start: 2011. Münker TJAG. CRANIOSAFE: Optimized and innovative materials and customized treatment strategies for cranioplasty. Supervisors: prof.dr. A.J. Feilzer, prof.dr. C.J. Kleverlaan & prof.dr. A.G. Becking; start: November 2016. Nikolopoulou M. Effects of comorbidities on OSAS and its treatment outcome. Supervisors: prof.dr. F. Lobbezoo & prof.dr. J. de Lange; co-supervisors: dr. G. Aarab & dr. J. Ahlberg, start: 2014. Nolte JW. Distraction osteogenesis in orofacial surgery. Supervisors: prof.dr. A.G. Becking & prof.dr. D.B. Tuinzing, start: 2011. Pathak JL. The etiology of generalized osteoporosis in rheumatoid arthritis. Supervisors: prof.dr J. Klein-Nulend & prof.dr. F.P. Luyten; co-supervisors: dr. A.D. Bakker, dr. N. Bravenboer & prof.dr. P. Vanderschueren, start: October 2011, end 2016. Renders GAP. Something to chew on. The neverending µCT story of bone and cartilage. Supervisor: prof.dr. V. Everts; co-supervisor: dr. G.E.J. Langenbach, start: 2007, end 2017. Restrepo Serna CMC. Bruxism in a stratified general population sample of children in Colombia. Supervisors: prof.dr. F. Lobbezoo & prof.dr. D. Manfredini, start: 2014. Rocca GT. Adhesive restoration of endodontically treated posterior teeth. Supervisors: prof.dr. A.J. Feilzer & prof.dr. I. Krejci, start: 2012. Rozeboom AVJ. Treatment of fractures of the condylar head. A randomized clinical trial. Supervisors: prof.dr. J. de Lange & prof.dr. R.R.M. Bos, start: September 2011. Ruslin M. Etiology of relapse after orthognatic surgery. Supervisors: prof.dr. T. Forouzanfar & prof.dr. D.B. Tuinzing, start: 2011. Saatchi A. Development and implementation of medical treatments for bone defects and bone disease. Supervisors: prof.dr.ir. G. Amoabediny (University of Tehran, Iran) & prof.dr. J. Klein-Nulend; co- supervisors: dr. M.N. Helder (VUmc) & dr. B. Zandieh Doulabi, start: 2013. Salehi-Nik S. Effects of surface modification and mechanical loading on the response of endothelial cells loaded in biohybrid lung bioreactors. Supervisors: prof.dr.ir. G. Amoabediny (University Tehran, Iran) & prof.dr. J. Klein-Nulend; co-supervisors: dr. B. Zandieh Doulabi & prof.dr. M.H. Shokrgozar, start: 2012. Salentijn EG. Midfacial trauma patients: An epidemiological survey. Supervisors: prof.dr. T. Forouzanfar & prof.dr. E.A.J.M. Schulten, start: 2014. Scholtanus JD. Bonding to carious dentin. Supervisors: prof.dr. A.J. Feilzer & prof.dr. M. Özcan; co-supervisor: prof.dr. C.J. Kleverlaan, start: April 2009, end 2016. Shang L. Different interactions between commensal and pathogen with host cells. Supervisors: prof.dr. C. van Loveren & prof.dr. S. Gibbs; co-supervisors: prof.dr. W Crielaard & dr. D.M. Deng, start: 2015.

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Shi X. A comparison between two different oral appliance therapies: Somnodent vs Herbst appliance in patients with mild and moderate OSA: a Randomised Controlled Trial. Supervisors: prof.dr. F. Lobbezoo & prof. dr. J. de Lange; co-supervisor: dr. G. Aarab & dr. W.E.R. Berkhout, start: November 2016. Sprangers SL. Osteoclasts and their precursors. Supervisor: prof. dr. V. Everts; co-supervisor: dr.ir. T.J. de Vries, start: 2014, end 2017. Sun, W. Peptides and its derives to promote the spreading of osteoblasts. Supervisor: prof.dr. E.C.I. Veerman; co-supervisors: dr. G. Wu & dr. J.G.M. Bolscher start: August 2016. Tabeian H. The role of cytokines and mechanical loading in the degeneration of the temporomandibular joint. Supervisors: prof.dr. V. Everts & prof.dr. F. Lobbezoo; co-supervisors: dr. A.D. Bakker & dr.ir. T.J. de Vries, start: 2012, end: 2016. Tastepe CS. Peri-implantitis and implant cleaning methods. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. Y. Liu, start: 2012, end 2017. Tauböck TTKJ. Influence of light curing protocols on dental restorative resin composite material. prof.dr. A.J. Feilzer & prof.dr. T. Attin, start: September 2012. Ten Harkel B. Multinucleated giant cells versus osteoclasts. Supervisor: prof.dr. V. Everts; co-supervisor: dr.ir. T.J. de Vries, start: December 2011, end 2017. Teng, F. Vertical alveolar ridge augmentation using Bio-Oss® block incorporated with BMP-2. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. Y. Liu, start: October 2015. Thymi, M. Associations between sleep bruxism and (peri-)implant complications: a follow-up study. Supervisors: prof.dr. F Lobbezoo & prof.dr. D. Wismeijer; co-supervisor: dr. C.M. Visscher, start: 2014, end 2018. Tuijt M. The role of muscle function in internal derangements of the temporomandibular joint. Supervisor: prof.dr. F. Lobbezoo; co-supervisor: dr.ir. J.H. Koolstra, start: 2004, end 2017. Tuk JC. Anxiety and pain related to oral and maxillofacial surgery. Supervisor: prof.dr. J. de Lange; co- supervisors: dr. J.A.H. Lindeboom & dr. A.J. van Wijk, start: September 2012. Van den Bergh B. Epidemiology and treatment of mandibular trauma. Supervisors: prof.dr. T. Forouzanfar & prof.dr. D.B. Tuinzing; co-supervisor: dr. J.J. de Mol van Otterloo, start: 2009, end: 2016. Van der Kaaij NCW. Prevention of white spot lesions. Supervisor: prof.dr. J.M. ten Cate; co-supervisors: dr.ir. M.H. van der Veen & dr. E. Zaura, start: 2009. Van der Sleen JM. Dento-alveolaire chirurgie. Supervisor: prof.dr. J. de Lange, start: April 2012. Van der Zande, MM. What aspects play a role in Dentist’s decision making when looking at implementing digital tools into their practice. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. R.C. Gorter, start: 2013 end, 2017. Van Eekeren, PJA. Clinical consequences when changing the position of implant-abutment interface. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. A. Tahmaseb, start: 2012, end 2016. Van Esterik FAS. Bioresorbable materials for scaffolds in oral in oral regenerative medicine. Supervisors: prof.dr. J. Klein-Nulend & prof.dr. C.J. Kleverlaan, co-supervisor: dr. B. Zandieh Doulabi, start: October 2012. Van Grootel, RJ. Pain patterns and a novel way of evaluation of therapy outcome in myogeneous temporomandibular disorders. Supervisor: prof.dr. D. Wismeijer; co-supervisors: dr. H.W. van der Glas & dr. R. Buchner, end 2016. Van Velzen FJJ. Risk factors and complications in oral and maxillofacial implantology. Supervisors: prof.dr. C.M. ten Bruggenkate & prof.dr. E.A.J.M. Schulten, start: 2010. Veldhuizen R. In vitro assessment of titanium allergy. Supervisors: prof. dr. S. Gibbs & prof.dr. A.J. Feilzer; co- supervisor: prof.dr. C.J. Kleverlaan, start: 2014. Verlinden CRA. Maxillofacial distraction osteogenesis: experiences results & dilemmas. Supervisors.: prof.dr. T. Forouzanfar & prof.dr. D.B. Tuinzing. Wang, D. Osteoinductive and antibacterial biomaterials for bone tissue engineering. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. Y. Liu, start: 2012, end 2016. Wang T. Treatment of periodontal disease, prosthodontics evaluated by oral radiology. Supervisor: prof. dr. G.A. van der Weijden; co-supervisor: dr. D.E. Slot & dr. W.E.R. Berkhout, start: October 2016. Wetselaar P. The tooth wear evaluation system. Development and applications. Supervisor: prof.dr. F. Lobbezoo; co-supervisors: dr. C.M. Visscher & dr. M. Koutris, start 2013, end: 2016. Wolff JEH. Reconstructions of the craniomaxillo-mandibular skeleton: problems and solutions. Supervisors: prof.dr. T. Forouzanfar & prof.dr. G.K. Sandor.

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Zamani Y. Development of functional scaffolds for bone tissue engineering using 3D printing of cells and biomaterials. Supervisors: prof.dr.ir. G. Amoabediny (Tehran University, Iran) & prof.dr. J. Klein-Nulend (ACTA), co-supervisors: dr. B. Zandieh Doulabi (ACTA) & dr. M.N. Helder (Vumc), start: 2015. Zembic A. The 2 implant overdenture in the maxilla. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. A. Tahmaseb, start: 2012, end 2017. Zhang, X. Osteogenic traditional Chinese medicine for bone tissue engineering. Supervisors: prof.dr. D. Wismeijer & prof.dr. Y. Huang; co-supervisor: dr. Y. Liu, start: 2012, end 2017. Zygogiannis, K. Immediately loaded mini dental implants to retain mandibular overdentures: an alternative to the existing treatment protocols. Supervisor: prof.dr. D. Wismeijer; co-supervisors: dr. I.H.A. Aartman & dr. A. Tahmaseb Eghbali, start: 2012, end 2017.

Societal impact The societal impact of the scientific merits of the section of Oral Kinesiology is expressed by the various post- academical courses organized and large amount of lectures provided for professionals. Besides courses for dentists, also courses for other professionals in the field of orofacial pain have been organized, such as for mouth hygienists, physical therapists and dental assistants. In addition, on a regular basis, the expertise as developed in the section of Oral Kinesiology receives attention from the media. The societal impact of the clinical research on oral and maxillofacial surgery is focussed on the influence on patient care, both within the department and externally. Research contributes to improved treatment of relevant patient groups.

I. Societal relevance for the dental professional in the Netherlands

Courses organized for Dutch dental and medical professionals Aarab, G. & Wetselaar, P. (February 11 & 25, 2016). Organisation of a TMD-course for periodontologists in training, Amsterdam, the Netherlands. Aarab, G. & Wetselaar, P. (May 12, 2016). Organisation of a TMD-course for orthodontists and oral- maxillofacial surgeons (AMC and VUmc) i.o., Amsterdam, the Netherlands. Baart, J.A. (January 19, 2016). Cursus Lokale anesthesie voor assisterenden. VUmc, Amsterdam. Baart, J.A. (March 10, 2016). Lokale anesthesie voor assisterenden, VUmc, Amsterdam. Baart, J.A. (March 17, 2016). Cursus Dento-Alveolaire Chirurgie in de algemene praktijk. Baart, J.A. (April 20, 2016). WTA cursusavond NVT, Breukelen. Baart, J.A. (April 21, 2016). Cursus Lokale anesthesie voor assisterenden. VUmc, Amsterdam. Baart, J.A. (April & July 2, 2016). Lokale anesthesia voor assisterenden, Implacon, Garderen. Baart, J.A. (April 14, 2016). Lokale anesthesie voor assisterenden, VUmc, Amsterdam. Baart, J.A. (May 13, 2016). Dento-alveolaire chirurgie voor de tandarts algemene practicus. Dental Education, Baart, J.A. (June 16, 2016). Uitbreiding dentogene ontsteking, lokale anesthesie en extractie. Cursusdag Tropenartsen. Baart, J.A. (June 17, 2016). Cursus Dento-alveolaire chirurgie voor de tandarts algemene practicus. Dental Education, Amsterdam. Baart, J.A. (June 18, 2016). Cursus Lokale anesthesie voor assisterenden. Echt. Baart, J.A. (September 15, 2016). Cursus Lokale anesthesie voor assisterenden, VUmc Amsterdam. Baart, J.A. (September 18, 2016). Cursus Lokale anesthesie voor assisterenden, Apeldoorn. Baart, J.A. (October 13, 2016). Cursus Lokale anesthesie voor assisterenden, Apeldoorn. Baart, J.A. (October 13, 2016). WTA cursusavond vd NVT, Breukelen. Baart, J.A. (October 28, 2016). Cursus Dento-Alveolaire Chirurgie in de Cursus, Amsterdam. Baart, J.A. (November 4, 2016). Cursus Lokale anesthesie voor assisterenden, VUmc, Amsterdam. Berkhout, W.E.R. (14 January; 31 March; 2 June; 22 September; 20 October 2016). Stralingshygiënisch Gekwalificeerd Beroepsbeoefenaar – tandheelkunde. Berkhout, W.E.R. (29 January; 14 October-4 November 2016). Stralingshygiënisch Gekwalificeerd Beroepsbeoefenaar mbt CBCT. Berkhout, W.E.R. (5-19 February; 3-24 June; 25 November- 9 December 2016). Stralingshygiënisch Gekwalificeerd Beroepsbeoefenaar mbt CBCT, variant MKA.

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De Lange, J. (October 7-10,-2016). Cursus Slaap en OSAS voor tandartsen, ACTA, ADE. Hoogeveen, R.C. (29 January; 14 October-4 November 2016). Stralingshygiënisch Gekwalificeerd Beroepsbeoefenaar mbt CBCT. Hoogeveen, R.C. (5-19 February; 3-24 June; 25 November- 9 December 2016). Stralingshygiënisch Gekwalificeerd Beroepsbeoefenaar mbt CBCT, variant MKA. Koolstra, J.H. (April 21, 2016). Seminar Oral Anatomy. Koolstra, J.H. (October 13, 2016). Seminar Oral Anatomy. Langenbach, G.E.J. (October 13, 2016). Seminar Oral Anatomy. Langenbach, G.E.J. (November 30, 2016). Oral Anatomy (Masterclass Implantology). Sanderink, G.C.H. (2016). Stralingshygiënisch Gekwalificeerd Beroepsbeoefenaar – tandheelkunde. Sanderink, G.C.H. (29 January; 14 October-4 November 2016). Stralingshygiënisch Gekwalificeerd Beroepsbeoefenaar mbt CBCT. Schulten, E.A.J.M. (March 18, 2016). De geatrofieerde edentate kaak: nog niet het einde. ITI-themamiddag i.s.m. dr. J. Wolff. Symposium voor tandprothetici. Schulten, E.A.J.M. (September 23, 2016). De geatrofieerde edentate kaak: nog niet het einde. ITI- themamiddag i.s.m. dr. J. Wolff. Symposium voor tandartsen en tandprothetici, Van der Valk Hotel, Zwolle. Schulten, E.A.J.M. (October 6-7, 2016). Mond-Kaak-Speekselklierpathologie KIO-cursus. VUmc, Amsterdam. Schulten, E.A.J.M. (November 15, 2016). De edentate bovenkaak: behandeling op maat. ITI thema-avond i.s.m. prof.dr. C.M. ten Bruggenkate, Houten. Stroy, L.P.P. (November 28, 2016). Dento-alveolaire cursus voor de ACTA Dental Education BV. Tahmaseb, A. (2016). Cadaver Course on anatomy for the ITI. Rotterdam University. Wolff, J.E.H. & OMFS team. (May 13, 2016 – June 17, 2016). Surgical course for dentists, VUmc, Amsterdam.

Lectures given during courses for Dutch dental and medical professionals Aarab, G. (January 30, 2016). De klinische aspecten van een mandibulair repositie-apparaatbehandeling. Quality practice, Amsterdam. Aarab, G. (April 15, 2016). Jaaroverzicht, NVTS jaarcongres, Nieuwegein. Aarab, G. (April 16, 2016). Workshop Functieonderzoek en wasindex. BIG-herregistratiecursus, Amsterdam. Aarab, G. (September 24, 2016). Workshop Functieonderzoek en wasindex. BIG-herregistratiecursus, Amsterdam. Baart, J.A. (April 1, 2016). Autotransplantaties van gebitselementen. Zorgverzekeraars Nederland, Zeist. Baart, J.A. (April 15, 2016). Röntgenraadsels in de kaakchirurgie. QP (assisterenden), Utrecht. Baart, J.A. (April 22 & 23, 2016). Patiënten met geneesmiddelen. Kennisdagen Henry Schein, Almere. Baart, J.A. (May 21 & 28, 2016). Röntgenraadsels in de kaakchirurgie. OP themadag 5 (tandartsen), Utrecht. Baart, J.A. (May 31, 2016). Autotransplantaties. Orthodontie praktijk Van der Beek, Uithoorn. Baart, J.A. (June 9, 2016). Patiënten en hun pillen 2. SVP de mond focusvrij maken. NVT-NVMKA, CineMec, Utrecht. Baart, J.A. (June 9, 2016). Diagnostiek en behandeling in narcose van dementerenden. Lokale anesthesie en THK-chirurgie bij polyfarmacie. Geriatrie en de mond. Edudentaal, Rotterdam. Baart, J.A. (June 10, 2016). Polyfarmacie en de algemene praktijk. Rotterdam. Baart, J.A. (June 22 & 24, 2016). Geneesmiddelen en de dagelijkse praktijk. Henry Schein Dental, Almere. Baart, J.A. (November 18 & 25, 2016). Autotransplantaties van gebitselementen. Alumni, Nijmegen. Baart, J.A. (November 26 & December 3, 2016). Voordracht: SEH en aangezichtstrauma. QP tandartsen, Acute THK, ACTA. Baart, J.A. (November 26 & December 3, 2016). Nabloeding. Workshop QP tandartsen, Acute THK, ACTA. Baggen, J.H.M. (May 20, 2016). Aangezichtspijn, een zorg voor de tandarts? University meets practice congress, Venray. Baggen, J.H.M. (June 17, 2016). Post Academisch Onderwijs Tandheelkunde. OSAS I, Radboud UMC, Nijmegen Baggen, J.H.M. (September 16, 2016). Post Academisch Onderwijs Tandheelkunde. OSAS II, Radboud UMC, Nijmegen. Baggen, J.H.M. (October 1, 2016.) Gnathologie/Logopedie. Cobijt congres, Apeldoorn. Becking, A.G. (March 10, 2016). Mond, Kaak en Aangezicht, Nascholing anesthesiemedewerkers, Spaarne Gasthuis, Haarlem. Becking, A.G. (March 17, 2016). Samenwerking in chirurgische orthodontie. Vereniging van orthodontisten in opleiding, Soestduinen.

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Becking, A.G. (June 24, 2016). Orthognatische chirurgie en esthetiek, Quality Practice Mondhygiënisten, Jaarbeurs Utrecht. Berkhout, W.E.R. (April 4, 2016). Diagnostiek in de radiologie. ONT nascholing. Berkhout, W.E.R. (May 21 & 28, 2016). 1. Diagnostiek in de Radiologie. ACTA QP. 2. Diagnostiek met Conebeam CT. Workshop ACTA QP. De Lange, J. (November 18, 2016). Geïmpacteerde elementen: evidence based management? QP nascholingsdag mondhygiënisten, ADE, Utrecht. Delwel, S. (September 24, 2016). De PainDemiA-studie: het tandheelkundige deel. Symposium De mond niet vergeten! Amsterdam. De Vries, N. (January 22, 2016). Voordracht richtlijn OSAS, PAOK NVMKA, Putten. De Vries, N. (January 30, 2016). Behandelopties bij OSAS. Bijdrage ACTA-QP-cursus Slaap in de tandheelkunde, Amsterdam. De Vries, N. (January 30, 2016). Nieuwe technologieën op het gebied van OSAS. Bijdrage ACTA-QP-cursus Slaap in de tandheelkunde, Amsterdam. De Vries, N. (May 26, 2016). Positietherapie. Sleepness congres, Utrecht. De Vries, N. (June 8, 2016). OSA and bariatric surgery. Symposium Anesthesia in Bariatric Surgery, Bunschoten- Spakenburg. De Vries, N. (September 22-23, 2016). Diagnostiek: KNO-onderzoek. NVvO Najaarscongres, Leiden. De Vries, N. (September 22-23, 2016). Therapie: conservatief. NVvO Najaarscongres, Leiden. De Vries, N. (September 22-23, 2016). Therapie: KNO chirurgie. NVvO Najaarscongres, Leiden. De Vries, N. (October 5, 2016). ESGE (Gynaecology) Congress Brussel. How to survive a FDA inspection. Dubois, L. (April 9, 2016). De blinde vlek. ACTA Quality Practice: thema Medisch Tandheelkundige Interactie, Jaarbeurs, Utrecht. Dubois, L. (June 7, 2016). Maxillofacial Traumatology. The ABC’s of Trauma, AMC. Dubois, L. (June 24, 2016). 1. Tandletsel in de praktijk, de dillema’s. 2. Trauma van klein tot groot. ACTA QP Mondhygiëne, Jaarbeurs, Utrecht. Hoogeveen, R.C. (January 20, 2016).Update tandheelkundige radiologie, IQual-groep Amsterdam-Zuid. Hoogeveen, R.C. (May 21 & 28, 2016). Tandheelkundige Cone Beam CT en stralingsrisico's, objectief, relatief en subjectief beschouwd, ACTA QP. Hoogeveen, R.C. (May 21 & 28, 2016). Interactieve presentatie Orthodontische Radiologie, Workshop ACTA QP. Koolstra, J.H. (April 15, 2016). Innervatie van het kauwstelsel. Workshop Quality Practice Assistenten. Kuijs, R.H. (June 4 & 18, 2016). Gebitsslijtage, to treat or not to treat, what are the questions. ACTA Quality practice, Amsterdam. Lobbezoo, F. (January 30, 2016). Overzicht van de Tandheelkundige Slaapgeneeskunde. Bijdrage ACTA-QP- cursus Slaap in de tandheelkunde, Amsterdam. Lobbezoo, F. (January 30, 2016). Workshop Tandheelkundige screening (inclusief verkort functieonderzoek). Bijdrage ACTA-QP-cursus Slaap in de tandheelkunde, Amsterdam. Lobbezoo, F. (16 April, 2016). Diagnostiek en behandeling van TMD. BIG-herregistratiecursus, Amsterdam. Lobbezoo, F. (April 16, 2016). Workshop Functieonderzoek en wasindex. BIG-herregistratiecursus, Amsterdam. Lobbezoo, F. (April 21, 2016). Oral Kinesiology. Bijdrage ACTA-cursus Dentistry for non-dentists, Amsterdam. Lobbezoo, F. (June 2016). TMD-pijn. Een diagnostische update. Bijdrage ACTA-DE Leergang Endodontologie, Amsterdam. Lobbezoo, F. (September 2, 2016). TMD en gebitsslijtage. Bijdrage aan ACTA Summer School 2016. Amsterdam. Lobbezoo, F. (November 5, 2016). Effect van lifestyle-factoren op gebitsgezondheid. Bijdrage ACTA-QP Themadag Lifestyle & Mondgezondheid. Utrecht. Nolte, J.W. (June 17, 2016). Dikke wang. Klinische les/onderwijs Huisartsdocenten (HDC). Nolte, J.W. (November 24, 2016). Schisis. Ouderavond fusie AMC/VUMC voordracht ICHOMS / KLIK. Poorterman, J.H.G. (April 4, 2016). Diagnostiek in de radiologie. ONT nascholing. Poorterman, J.H.G. (May 21 & 28, 2016). Radiologie: rechtvaardiging en richtlijnen, ACTA QP. Poorterman, J.H.G. (October 1, 2016). Radiologie: rechtvaardiging en richtlijnen. Dental Clinics nascholing. Schulten, E.A.J.M. (April 1, 2016). 3D geplande bimaxillaire osteotomie, immediate implantologie en prothetiek. NVOI Studiedag Beurs van Berlage, Amsterdam. Schulten, E.A.J.M. (October 7, 2016). Dentogene cysten en tumoren. KIO-cursus Mond-Kaak- Speekselklierpathologie, VUmc, Amsterdam.

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Schulten, E.A.J.M. (November 24, 2016). Pre-implantologische chirurgie. NVOI-cursus De Verdieping, Hotel Van der Valk, Veenendaal. Schulten, E.A.J.M. (2016). Dento-alveolaire chirurgie voor tandartsen. Docent ACTA-DE cursus (3x per jaar). Schulten, E.A.J.M. (2016). Docent NVOI-cursus De Verdieping (1x per jaar). Thymi, M. & Lobbezoo, F. (June 2016). Bruxism. A brief overview for the clinician. Seminar Postgraduate master program, profile Oral Implantology, Amsterdam. Van Daelen, A.J.C. (January 26, 2016). De bovenbouw. Cursus NVOI, samen met R.J. Goené en prof. H. Meijer, Houten. Van Daelen, A.J.C. (April 21, 2016). De bovenbouw. Cursus NVOI, samen met R.J. Goené en prof. H. Meijer, Hoorn. Van Daelen, A.J.C. (October 6, 2016). De bovenbouw. Cursus NVOI, samen met R.J. Goené en prof. H. Meijer, Rotterdam-Nieuwerkerk. Van Daelen, A.J.C. (October 29, 2016). Person to person, klinische cursus implantologie chirurgie en prothetiek (live surgery), samen met R.J. Goené. Tendens Tandartsen, Amsterdam. Van Daelen, A.J.C. (November 26, 2016). Person to person, klinische cursus implantologie chirurgie prothetiek (live surgery), samen met R.J. Goené. Tendens Tandartsen, Amsterdam. Van Loon, J.J.W.A. (April 15, 2016). Gravity related experimentation in space and on ground, master course Medische Natuurwetenschappen, VU-University, Amsterdam, NL. Van Waas, M.A.J. & Wismeijer, D. (November 18-19, 2016). De volledige gebitsprothese, een update. ADE ACTA Amsterdam. Weijenberg, R.A.F. (April 16, 2016). Maakt kauwen slimmer? Workshop VU lustrum Event, Amsterdam. Weijenberg, R.A.F. (September 1, 2016). Are periodontal disease and lack of mastication risk factors for dementia? Lezing Lustrumcongres 25 jaar opleiding tot Parodontoloog, Amsterdam. Weijenberg, R.A.F. (September 23 & 24, 2016). 1. Kauwen en cognitie workshop, 2. Kauwen en dementie. Congres De Mond Niet Vergeten, Amsterdam. Wetselaar, P. (September 30, 2016). Diagnostiek van gebitsslijtage. Dental Design Academy, Blaricum. Wetselaar, P. (November 5, 2016). Herstel van lifestyle schade binnen Oraal Kinesiologische aandachtsgebieden. Life Style & Mondgezondheid, ACTA Quality Practice themadag, Utrecht. Wismeijer, D., Tahmaseb, A. & Hassan, B. (2016). Course and lectures on Oral Anatomy (Masterclass Implantology), runs the whole year, ACTA DE. Wismeijer, D. (January 15, 2016). Surgical aspects of peri-implantitis. Course for Dutch Dentists KNMT region Midden Gelderland. Wismeijer, D. (January 22, 2016). 3D printing in Dental: A game changer. Congress opening Vertex Building, Soesterberg. Wismeijer, D. (February 19, 2016). Periimplantitis Van Tandvlees naar Implantaat Vlees. Cursus ONT (ACTA DE). Wismeijer, D. (March 19, 2016). Implanteren in de algemene praktijk met het Straumann® Dental Implant System Verwijspraktijk voor Orale Implantologie, Dieren. Wismeijer, D. (June 24, 2016). Het implantaat: mogelijkheden en valkuilen. Utrecht. QP thema dag voor Mondhygiënisten. Wismeijer, D. (November 24-25, 2016). 1. Implantologie in een digitale omgeving. 2. Bruggen op implantaten. NVOI de verdieping.

Organization of congresses and symposia for professionals in the Netherlands Aarab, G. (January 30, 2016). Organiser and moderator Quality practice: Slaap in de Tandheelkunde. Amsterdam, the Netherlands. Baart, J.A. (December 9, 2016). Diagnose in beeld. Wintersymposium & Van der Kwastlezing. Berkhout, W.E.R. (March 12, 2016). Chairman ANT Startercongres. De Lange, J. (2016). Organization Hoofdhalskanker anno 2016. KNMT/AMC/AVL nascholingsavond. De Lange, J. (2016). Organization Reünistendag Antoni van Leeuwenhoek Hoofdhals-chirurgie. De Lange, J. (2016). Organization PAOK 2016: Werken aan richtlijnen. De Lange, J. (March 9, 2016). Organization AB profylaxe, klinische avond ACTA. De Lange, J. (November 11, 2016). Organization NMT/AVL/AMC Oncologie, klinische avond ACTA. De Lange, J. (November 18, 2016). Organisation QP nascholingsdag mondhygiënisten. De Lange, J. (December 7, 2016). Organization Innovaties in de tandheelkunde, klinische avond ACTA.

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Lobbezoo, F. (September 23 & 24, 2016). Organiser and moderator ACTA-DE Symposium De Mond Niet Vergeten, Amsterdam. Poorterman, J.H.G. (May 21 & 28, 2016). Organiser and moderator ACTA QP voor tandartsen, Jaarbeurs, Utrecht.

Invited speakers at professional congresses or symposia in the Netherlands Baart, J.A. (February 3, 2016). Kindertandheelkunde. Lokale anesthesie bij kinderen? RAI, Amsterdam. Baggen, J.H.M. (February 16, 2016). Burning Mouth Syndroom en suïcide. Pijnpoli UMC Radboud, Nijmegen. Baggen, J.H.M. (February 19, 2016). OSAS voor orthodontisten. Radboud UMC, Nijmegen. Baggen, J.H.M. (October 26, 2016). Aangezichtspijn. Iqual group mondhygiënisten, Utrecht. Baggen, J.H.M. (November 9, 2016). Gnathologie en de tong. Iqual groep tandartsen. Nijmegen. Becking, A.G. (September 2, 2016). Afscheid prof.dr. R.R.M. Bos, voordracht namens SORG. Berkhout, W.E.R. (November 18, 2016). Digital Radiology at congress Digitale Praktijk Kalker. Berkhout, W.E.R. (December 8, 2016). Verder kijken – meer zien. Precongress NVGTP. Bos, A. (March 18, 2016). Beeldvorming in de orthodontie: Hoe kijken orthodontisten en patiënten naar elkaar? NVvO congres. De Lange, J. (March 11, 2016). Derde molaren en apexresecties: indicatiestelling en behandeluitkomst. ANT jaarcongres, RAI, Amsterdam. De Vries, N. (January 22, 2016). Complicaties van OSAS chirurgie. Complicatiecursus, Leiden. De Vries, N. (March 24, 2016). OSAS. OSAS voorlichtingsavond OLVG West, Amsterdam. De Vries, N. (August 13, 2016). OSAS diagnostiek en behandeling. KNO UMCU, Utrecht. De Vries, N. (October 29, 2016). N. hypoglossusstimulatie (keynote speaker). Refereeravond longartsen OOR Utrecht Diaconessen ziekenhuis, Utrecht. De Vries, N. (November 26, 2016). OSAS en snurken. Luchtwegmanagement. Albert Schweitzer Ziekenhuis, Dordrecht. Dubois, L. (2016). Mondzorg voor oncologische patiënten. IT Groep Mondhygiënisten Gooi. Dubois, L. (2016). Orastem study. Verpleegkundig Netwerk Interne-hemato oncologie IKNL, Amsterdam. Gimenez Gonzalez, B. (June 23, 2016). Intra oral scanners, 3M ESPE, Delft, the Netherlands. Lobbezoo, F. (April 15, 2016). Bruxisme ter preventie van OSAS: Luchtkauwerij? Voordracht 8e NVTS-congres In het holst van de nacht, Nieuwegein. Lobbezoo, F. (April 22, 2016). Orofaciale pijn bij ouderen. Topics in de Ouderengeneeskunde en ouderenzorg 2016, Maastricht. Lobbezoo, F. (September 23 & 24, 2016). Introduction and general discussion. ACTA-DE Symposium De Mond Niet Vergeten, Amsterdam. Lobbezoo F. (November 4, 2016). Bruxisme: State-of-the-Art. Slaap2016, Ermelo. Van Daelen, A.J.C. (January 14, 2016). Oligodontie, een interdisciplinaire benadering. NVVRT pre-symposium Restauratief voor jong en oud, Amsterdam. Van Daelen, A.J.C. (March 18, 2016). Schoonheid in tandheelkunde, kiezen voor harmonie. Dentsply assistentendag, Hilversum. Van Daelen, A.J.C. (April 1, 2016). Implanteren in het onderfront, waarom (niet)? Landelijke studiedag Implantologie NVOI, Amsterdam, Van der Stelt, P.F. (September 8, 2016). Röntgenologisch onderzoek in de Gnathologie, Congres Ned. Ver. Gnathologie en Prothetische Tandheelkunde, Ermelo. Visscher, C.M. (November 11, 2016). TMD and atypical facial pain. Interdisciplinary pain symposium: Pain in the Head and Neck Area, Utrecht, the Netherlands, Weijenberg, R.A.F. (May 20, 2016). Kauwen, cognitie en dementie. Opleiding Tandarts Geriatrie, Amsterdam. Weijenberg, R.A.F. (June 1, 2016). Kauwen en mondgezondheid bij ouderen met dementie. Nascholing studiegroep geriatrie, Bilthoven. Wismeijer, D. (June 3, 2016). De bal is rond en aan het rollen. VIT: Implantologie is topsport, Maastricht, the Netherlands. Wismeijer, D. (November 11, 2016). Your dental practice: What will the future hold? NVOI congress, Den Haag, the Netherlands. Wismeijer, D. (November 18, 2016). 1. Digitale ontwikkelingen: Waar staan we nu eigenlijk? 2. Digitale ontwikkelingen: Wat staat ons nu te wachten? Congres Digitaal in de Tandartspraktijk. Rai, Amsterdam, the Netherlands.

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Professional functions in the Netherlands Baart, J.A.: Lid Bestuur NWVT. Baart, J.A.: Voorzitter WTA cie NWVT. Baart, J.A.: Voorzitter WTA leescie (Hamer Duyvenszprijs). Becking, A.G.: Lid Implementatie commissie competentiegericht opleiden MKA, Nederlandse Vereniging voor Mondziekten, Kaak- en Aangezichtschirurgie (NVMKA). Becking, A.G.: Lid Commissie onderzoek en aanbeveling, NVMKA. Becking, A.G.: Lid Concilium Chirurgicum Oris. Becking, A.G.: Lid Stipendium commissie BOOA research grant, NVMKA. Becking, A.G.: Voorzitter Maatschap MKA, Kennemerland. Becking, A.G.: Opleider Perifere deelopleiding MKA, Kennemer Gasthuis, Haarlem. Becking, A.G.: Lid Centrale Opleidingscommissie, Kennemer Gasthuis. Haarlem. Becking, A.G.: Medisch manager MKA, Kennemer Gasthuis, Haarlem. Berkhout, W.E.R.: Member College van Opleiders Stralingsopleidingen 2013-. Berkhout, W.E.R.: Member Raad van Commissarissen Nederlands Tijdschrift voor Tandheelkunde 2013-. Berkhout, W.E.R.: Member Redactieadviesraad ACTA QP. Berkhout, W.E.R.: Coördinerend stralingsdeskundige - VU-ACTA Amsterdam 2013-. Berkhout , W.E.R.: Member expert panel, Symposium Taakherschikking – Nieuwspoort, Den Haag. De Lange, J.: Bestuurslid (inkomend voorzitter) NVMKA. De Lange, J.: Voorzitter CTS. De Lange, J.: Lid Capaciteitsorgaan. De Lange, J.: Lid Consilium Chirurgicum Oris (CCO). De Lange, J.: Lid COK. De Lange, J.: Lid CKC KNMT. De Lange, J.: Redactielid Quality Practice. Disse, M.A.: Vice-president RTS. Disse, M.A.: Dutch representative (member) Efosa. Disse, M.A.: Member; The Amsterdam Cleft Lip and Palate team, location VUmc/ACTA. Dubois, L.: Chef de kliniek WPM. Dubois, L.: Lid Expertise team divisie chirurgie. Dubois, L.: Lid Richtlijn spoedoperaties kwaliteitsinstituut medisch specialisten (NVH). Dubois, L.: Secretaris Stichting Bridge the Gap, NOMA en schisis team. Dubois, L.: Lid Coördinatie Commissie Traumatologie AMC. Kramer, G.J.C.: Member Schisisteam MCA Alkmaar. Kramer, G.J.C.: Chair/secretary Special Interest group ortodontics NVSCA. Kuitert, R.B.: Member Centraal College. Kuitert, R.B.: Member Concilium Orthodonticum. Kuitert, R.B.: Member European Teachers' Forum. Kuitert, R.B.: Member Nebeop/visiting assessment committee. Lobbezoo, F.: Chair Curatorium Bijzondere Leerstoel Angst- en Gedragsstoornissen in de Tandheelkundige Praktijk, since 2014. Lobbezoo, F.: Chair Curatorium Bijzondere Leerstoel Kwaliteit van Mondzorg, since 2015. Lobbezoo, F.: Chair Curatorium Bijzondere Leerstoel Mondgezondheid en Kwaliteit van Leven, since 2015. Lobbezoo, F.: Member Interim Management Team, MOVE Research Institute, Amsterdam. Nijkamp, P.: Member Schisisteam, Den Haag-Leiden. Nijkamp, P.: Consultant orthodontist CBT afdeling MKA-chirurgie LUMC.

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Nolte, J.W.: Lid dagelijks bestuur fusie Schisisteams AMC/VUmc. Nolte, J.W.: Vice voorzitter Vereniging Medisch Tandheelkundige Interactie (VMTI). Tahmaseb, A.: Board Member; responsible for training and education in the Benelux, Dutch ITI. Van Daelen, A.J.C.: Lid Visitatiecommissie tandarts-implantoloog NVOI, since 2008. Van Daelen, A.J.C.: Mondonderzoeker Centrale klachtencommissie van de KNMT, since 2003. Van Daelen, A.J.C.: Lid Opleidingscommisssie NVVRT (opleiding Restauratief tandarts), since 2015. Van der Kaaij, N.C.W.: Member Schisisteam Erasmus MC, Sophia kinderziekenhuis. Van der Stelt, P.F.: Director Nederlands Tijdschrift voor Tandheelkunde BV, Houten 2005-. Van der Stelt, P.F.: Chair Stichting Bevordering Tandheelkundige Kennis, Houten 2005-.

II. Societal relevance for the dental professional internationally

Professional functions internationally Becking, A.G.: President SORG (Strasbourg Osteosynthesis Research Group). Becking, A.G.: Visiting professor Universitat International Catalunya, Barcelona, Spain. Becking, A.G.: Visiting surgeon Cipto Mangukusumo Hospital, Jakarta, Republic of Indonesia. De Lange, J.: Faculty member and chairman SORG Trauma section. De Lange, J.: Faculty member AOCMF. De Lange, J.: Member KLS Martin expertise group Osteosynthesis. Dubois, L.: Member SORG Trauma section. Dubois, L.: Member KLS Martin expertise group Osteosynthesis. Gimenez Gonzalez, B.: Board member Spanish Society of Aesthetic and Prosthetic dentistry (SEPES). Koutris, M.: Board member Greek Society of Orofacial Pain, since 2014. Koutris, M.: Member RDC-TMD Consortium, Calibration Committee, since 2014. Koutris, M.: Member RDC-TMD Consortium, Governance Committee, since 2015. Visscher, C.M.: Board member Physical Therapy Board of Craniofacial and Cervical Therapeutics (PTBCCT), USA, since 2003. Wismeijer, D.: Board Member ITI. Wismeijer, D.: Board Member Digital Dentistry Society (DDS). Wismeijer, D.: Chairman ITI Education Committee. Wismeijer, D.: Examiner Royal College of Surgeons of Edinburgh. Wismeijer, D.: Member Scientific Advisory Board (SAB) International Association of Digital Dentistry (IADD).

Organization of international congresses and symposia for (health care) professionals Gimenez Gonzalez, B. (February 6-7, 2016). Young president Young Values SEPES in charge of the Valores, SEPES SYMPOSIUM, Madrid, Spain. Gimenez Gonzalez, B. (July 8-10, 2016). Coordinating and moderating Campus SEPES (Consensus Meeting), Vitoria, Spain. Koutris, M. (April 16, 2016). Organizing committee. TMD and Orofacial Pain: Clinical approach, Society of Contemporary Dentistry, Athens, Greece. Koutris, M. (June 25, 2016). Organizing committee. How can the DC/TMD improve education and clinical practice? Symposium, Co-organizer: prof. Thomas List, IADR meeting, Seoul, South Korea. Wismeijer, D. (October 15, 2016). Chair organizing committee. Working groups on the Prisma system for systematic reviews. (1st conference in preparation of the ITI consensus conference 2018). Zurich, Switzerland.

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Invited speakers at international professional congresses or symposia Aarab, G. (June 9-10, 2016). 1. The associations between sleep bruxism and OSA. 2. Titration, where to start? AADSM meeting, Denver, VS. Aarab, G. (March 25, 2016). 1. Overview of OSA. 2. Diagnosis of OSA. Dental School of Jinan, China. Aarab, G. (March 26, 2016) 1. Sleep Bruxism. 2. Associations between sleep bruxism and other sleep related disorders.Dental School of Jinan, China. Aarab, G. (March 29, 2016). 1. Overview of OSA. 2. Clinical procedure of oral appliance therapy in OSA patients. Dental School of X’ian, China. Aarab, G. (November 26, 2016). 1. Temporomandibular side-effects of oral appliance therapy in obstructive sleep apnea. 2. The clinical aspects of oral appliance therapy in obstructive sleep apnea. DGFDT meeting, Bad Homburg, Germany. Becking, A.G. (February 24-25, 2016). 1. Contemporary orthognathic surgery. 2. Planning orthognathic surgery in Caucasian faces compared to Asian faces (together with Mike Leung Hong Kong University). KPPIKG2016, scientific meeting and refresher course in Dentistry, Jakarta, Indonesia. Becking, A.G. (April 9, 2016). 1. Unilateral condylar hyperplasia. 2. Interceptive class 3 treatment. 3. Transoral zygoma osteotomy. Cursus diploma orthognathic surgery, Universidad Internacional Cataluña, Barcelona, Spain. Becking, A.G. (May 10, 2016). 1. Conventional planning in relation to 3D virtual planning in orthognathic surgery. 2. Le Fort osteotomy, the details. SORG modular basic course on orthognathic Surgery, Tuttlingen, Germany. Becking, A.G. (October 1, 2016). Conventional planning in orthognathic Surgery, SORG course on planning and pitfalls in Orthognathic Surgery, Liverpool, UK. Becking, A.G. (October 17, 2016). Planning and workflow in orthognathic Surgery, Sydney Orthodontic and Surgical, Sydney, Australia. Becking, A.G. (October 19, 2016). 1. Unilateral condylar hyperplasia. 2. Workflow and planning for asymmetry in orthognathic surgery. Facial Asymmetry Masterclass and 3D planning Workshop, preconference course to ANZAOMS, Gold Coast, Australia. Berkhout, W.E.R. (September 2, 2016). Radiologie, diverse lezingen. Cursus Nascholingsinstituut Vlaamse Vereniging van Tandartsen. De Lange, J. (January 28-29, 2016) 1. Medial Orbital Wall Fractures. 2. What is the ideal material for orbital reconstruction? 3. Eye epithetic and extra-oral implants. AO advanced course on orbital trauma, EMC, Rotterdam. De Lange, J. (May 8-13, 2016). 1. Complex fractures of the mandible. 2. Surgical approaches. SORG Comprehensive course, Tuttlingen, Germany. De Lange, J. (July 7-9, 2016). 1. Osteosynthesis techniques in the mandible, principles and definitions. 2. Treatment of isolated central and centro-lateral (Le fort type) fractures, buttress stabilization. 3. Zygomatic fractures. AO basic course, Chandigarh, India. De Lange, J. (November 11-12, 2016). Closed treatment of condylar fractures: a systematic review. SORG course on condylar fractures. De Vries, N. (October 21-23, 2016). Positional therapy in OSA. Spanish ENT Meeting, Sevilla, Spain. De Vries, N. (2016). Drug induced Sleep Endoscopy course. American Academy of Otolaryngology/ Head Neck surgery. De Vries, N. (2016). Obstructive Sleep Apnea Surgery Course with hands on Cadaver, 3-day Muscat, Oman. De Vries, N. (2016). Surgically Oriented Hands-On Workshop, 3-day OSAS Surgery International Course, Orlando, Florida. Dubois, L. (January 28, 2016). 1. Indications and timing of orbital reconstruction. 2. Approaches from above. 3. 3d Planning in orbital surgery AO CMF Course Advances on the Orbit, Rotterdam. Dubois, L. (May 20-21, 2016). 1. Two approaches of secondary correction of combined orbital- zygomatic complex fractures with patient specific implants: the orbit first! 2. Lower lid approaches. Optimisation in CMF Trauma Care, SORG course Surgical approaches for CMF trauma, Groningen. Dubois, L. (September 13-14, 2016). 1. What is the most reliable method for diagnosing the complexity of orbital fractures? 2. THE ORBIT FIRST! Secondary correction of combined orbital-zygomatic complex fractures with patient specific implants. EACMFS 2016, London, UK. Dubois, L. (October 20-21, 2016). Prebent and preformed mesh for primary orbital reconstruction, 2. Implant oriented navigation for orbital reconstruction. Current Clinical Concepts in Orbital Reconstruction, KLS Martin, Tuttlingen, Germany.

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Gibbs, S. (February, 23-24, 2016). Wound Healing. Workshop Novatis. Basel, Sweden. Gibbs, S. (December 7, 2016.) Soft tissue repair: in vitro models. Nobel BioCare, Zurich, Sweden. Gimenez Gonzalez, B. (May 6, 2016). Intra-oral scanners. University Rey Juan Carlos, Madrid, Spain. Gimenez Gonzalez, B. (November 17, 2016). Future of dentistry- Technology. Round table, 3M ESPE,Seefeld, Germany. Gimenez Gonzalez, B. (December 17, 2016). Digital dentistry. Postgraduate training in prosthodontics (4 hour course). Hassan, B. (July 20-24, 2016). Implant Dentistry. Summer school course. Association of Advanced Interdisciplinary Dentistry, Vienna, Austria. Liu, Y. (2016, August 4-7). 1. Soft Tissue Expansion: Principles and inferred intraoral hydrogel tissue expanders. 2. Biobone: Research and development. Taishan Scholars International Symposium on Stomatology, Yantai, China. Liu, Y. (November 18-20, 2016). Development and pre-clinic studies of Biobone. Symposium in biomimetics, School of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, China. Liu, Y. (2016, December 4). New materials in implant restorations. ITI study club: Beijing, China. Koutris, M. (April 1, 2016). Orofacial Pain. Postgraduate symposium in Advanced Physiotherapy, Lamia, Greece. Koutris, M. (April 16, 2016.) TMD: Introduction-Classification-Treatment. TMD and Orofacial Pain: Clinical approach, Society of Contemporary Dentistry, Athens, Greece. Koutris, M. (September 7, 2016). Practical management of bruxism. 53rd Annual congress of the Stomatological Society of Greece, Kalamata, Greece. Koutris, M. (November 21, 2016). Bruxism: management at the dental practice. Webminar, Stomatological Society of Greece, Kalamata, Greece. Lobbezoo, F. (January 15, 2016). Kauwen op bruxisme. Congres prof.dr. Bernard De Mot 65 jaar & 40 jaar Stagecentrum Tandheelkunde KULeuven, AZ Sint-Jan, Brugge, Belgium. Nolte, J.W. (January 5, 2016). 1. Trauma. 2. Unilaterale condylaire hyperplasie. Sri Sai College, Hyderabad, India. Raber-Durlacher, J.E. (November 8-9, 2016). Low level laser therapy for the management of oral cGHVD. German, Austrian, Swiss GVHD Working Group, Basel, Switzerland. Schulten, E.A.J.M. (April 15, 2016). How to avoid surgical complications in implant dentistry. ITI Benelux Congres, Maastricht. Teng, F. (May 23-27, 2016). Biomimetic calcium phosphate bone substitute for bone tissue engineering. World biomaterials conference, Canada. Teng, F. (2016, August 4-7). BMP2 slow release from Bio-Oss Block, in vitro study. Taishan Scholars International Symposium on Stomatology, Yantai, China. Teng, F. (September 29 - October 1, 2016). Modification of implant necks to enhance attachment between implants and peri-implant soft issue: an experimental study in beagle dogs. European Association for Osseointegration (EAO), Paris, France. Teng, F. (October 18-21, 2016). In-vitro evaluation of biomimetic incorporation and release kinetics of BMP2 on functionalized Bio-Oss® Block. Travel Scholarship Bioceramics 28, Charlotte, North Carolina, USA. Teng, F. (October 21, 2016). Development and preclinical studies of Biobone - BMP2 with xenogenic bone replacement material. Freiburg University, Germany. Van der Stelt, P.F. (September 2, 2016). Digitale Radiologie. Nascholingsinstituut Vlaamse Vereniging van Tandartsen, Aalst, Belgium. Wismeijer, D. (May 5-6, 2016). 1. History of oral implantology. 2. The edentulous patient (surgery). 3. The edentulous patient (prosthetics). 4. Implants in the esthetic zone. 5. Connecting implants to natural teeth. 6. Occlusion. 7. The future of oral implants. Two day course for Chinese dentists, China. Wismeijer, D. (August 1, 2016). 3D in dentistry: A game Changer. ITI study club in Perth, Australia. Wismeijer, D. (August 22, 2016). 3D in dentistry: A game Changer. ITI study club in Melbourne, Australia. Wismeijer, D. (August 28 – September 2, 2016). 1. Are implants in the esthetic zone predictable. 2. Ceramics in implant dentistry. 3. Digitization in Implant dentistry. ITI education week, Hong Kong, China. Wismeijer, D. (September 10, 2016). Digital implant Dentistry. Studiengruppe fur Restauratieve Zahnheilkunde. Dusseldorf, Germany. Wismeijer, D. (September 30, 2016). Hand guided versus digital guided surgery. EAO Paris, France. Wismeijer, D. (October 6-8, 2016). Hand guided versus digital guided surgery. German Academy of Esthetic Dentistry. Tegerensee, Germany.

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Wismeijer, D. (October 15, 2016). 3D printing in dental. Working groups on the Prisma system for systematic reviews. (1st conference in preparation of the ITI consensus conference 2018). Zurich, Switzerland. Wismeijer, D. (October 21, 2016). 1. Keynote lecture: 3D printing in dental: A game changer. 2. Hand guided versus digital guided implant placement. Congress on digital in dental. University of Freiburg Dental School. Wismeijer, D. (December 3, 2016). Peri-implantitis and its treatment modalities. Beijing Dental School, China.

III. Contacts with the general public

Interactions with the press and the general public Bakker, A.D. (October 3, 2016). Proefkonijnen. Interview in programma NPO3, BNN. https://www.npo.nl/ proefkonijnen/03-10-2016/BNN_101380625 Berkhout, W.E.R. & Poorterman, J.H.G. (January 1, 2016). Röntgendiagnostiek waardevol in de tandartspraktijk, maar de toepassing schept ook verplichtingen. Interview Quality Practice 11 (5): 4-6. http://www.qualitypractice.nl/tandartsen/tijdschrift/tijdschrift_artikel/t/rontgendiagnostiek_waardevol_in _de_tandartspraktijk_maar_de_toepassing_schept_ook_verplichtingen Berkhout, W.E.R. (October 3, 2016). Taakherschikking Mondzorg, Interview BNR (Business News Radio), Amsterdam. https://www.bnr.nl/nieuws/zorg/10311667/mondhygienist-krijgt-financieel-belang Gibbs, S. (April 4, 2016). Nieuwe Kweekhuid: nu ook met haar en zweetklieren. http://www.volkskrant.nl/wetenschap/nieuwe-kweekhuid-nu-ook-met-haar-en-zweetklieren~a4275062/ Gibbs, S. (July 6, 2016). Human immune competent skin disease models as next generation in vitro models. Media contribution, NAT SIG, Netherlands, Web. This news item was provided by dr. Lambert Bergers (VU University Medical Center, Amsterdam, the Netherlands), a co-author on the referenced review article https://connect.innovateuk.org/web/non-animal-technologies/article-view/-/blogs/human-immune-competent-skin-disease-models-as-next-generation-in-vitro-models?utm_source=newsletter&utm_medium- =email&utm_campaign=NATs%207%20July Gibbs, S. (March 12, 016). More accuracy with fewer animals. Interview Experiment NL; Science in the Netherlands NWO pg. 88 Experiment NL; Science in the Netherlands NWO, Netherlands, Print. http://www.nwo.nl/en/about-nwo/media/publications/experiment-nl/experiment-nl-2016-uk.html Gibbs, S. (March 19, 2016). Het hart op de chip. Interview De Volkskrant. Sir Edmund (National), Netherlands, Print. Hoogeveen, R.C. (January 1, 2016). De promotie: Alleen belichten wat nodig is voor de diagnostiek. Dosisverlaging bij orthodontische röntgenfoto’s. Interview Tandartspraktijk 37 (5): 27-29. https://mijn.bsl.nl/dosisverlaging-bij-orthodontische-roentgenfoto-s/10274522 Kreulen, E. (December 16, 2016). Het bitje tegen tandenknarsen: goedkoop is duurkoop. Trouw, de Verdieping, p. 12. Milheiro, A. (January 2016). Onder de loep! Interview Ana Milheiro Nederlands Tijdschrift voor Tandheelkunde 123 (3): 125. http://www.ntvt.nl/nieuws/onder-de-loep-ana-milheiro Nissinen, A. (2016). Voiko brusauksesta olla jotain hyötyä? Suomen Hammaslääkärilehti;14:20. Pronk, I. (January 29 ,2016). Het consult. Waarom tandenknars ik ‘s nachts? Trouw, , de Verdieping, p. 7. Roeters, F.J.M. (January 2016). Cosmetiek in de tandheelkunde: het gaat om de balans tussen doen en laten. Interview Quality Practice Mondhygiëne 8 (4): 4-6. http://www.qualitypractice.nl/mondhygienisten/tijdschrift/tijdschrift_artikel/t/cosmetiek_in_de_tandheelkunde_het_gaat_om_de_balans_tuss en_doen_en_laten Scholtanus, J.D. (January 2016). De promotie: Verkleuring van dentine door amalgaam. Hechting van composiet aan door amalgaam verkleurd dentine. Interview Tandartspraktijk 37 (7): 33-35. https://mijn.bsl.nl/verkleuring-van-dentine-door-amalgaam/10813908 Sevil, M. (March 19, 2016). De wachtkamer: Kaakknappen- Geluid producerende kaakgewrichten. Interview Parool. Sevil, M. (May 14, 2016). De wachtkamer: Tandenknarsen – Nare gewoonte blijkt toch nut te hebben. Parool. Tabeian, H. (January 1, 2016). Onder de loep! Interview Hessam Tabeian Nederlands Tijdschrift voor Tandheelkunde 123 (4): 178. Print http://www.ntvt.nl/nieuws/onder-de-loep-hessam-tabeian Van Loon, J.J.W.A. (October 19, 2016). NPO-ZAPP: Nederland In 2050 (EO). Contribution to this children’s program regarding living on Mars and return to Earth. http://www.npo.nl/nederland-in-2050/19-10- 2016/VPWON_1261605 Recording 7 July 2016: broadcast 19:20 hrs, NPO-3. Van Loon, J.J.W.A. (November 22, 2016). Gewichtig Onderzoek. Sterrenkundige Kring Minnaert Sonnenborg,

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Utrecht. Van Loon, J.J.W.A. (November 25, 2016). Skype-college voor project Ruimte van Basisschool Extralent te Venlo. Wismeijer, D. (January 22, 2016). 's Werelds eerste 3-D geprinte kroon op implantaat in Nederland geplaatst. http://www.dentaltribune.com/articles/news/netherlands/27409_s_werelds_eerste_3dgeprinte_kroon_in _nederland_geplaatst.html Dental Tribune interview, tekst door Marieke Epping.

Inaugural lectures De Vries, N. (May 20, 2016). The End of CPAP? Benoeming bijzonder hoogleraar Tandheelkundige Slaapgeneeskunde. Oratie Oude Lutherse Kerk, Universiteit van Amsterdam. Kleverlaan, C.J. (October 26, 2016). Op het grensvlak. Benoeming hoogleraar Biomaterialen. Oratie Oude Lutherse Kerk, Universiteit van Amsterdam.

Impact of the research on the general public or professionals Oral Implantology: Digital technologies in dentistry make the dental workflow more precise and dental treatment can be realized a lot quicker and possibly cheaper. This means that the dental treatment will have less impact on the patient’s everyday life. One of the mile stones we have reached in 2016 is the first 3D printed crown on a dental implant that was placed in a patient. The total material costs of this crown was 30 euro cents. Van der Stelt, P.F. (October 12, 2016). Overleg over vernieuwing Besluit basisveiligheidsnormen stralingsbescherming namens KNMT bij VWS, Den Haag.

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Education related research, including other research

Research on Dental Education Associate dean of educational research and development Dr. J.M. Vervoorn Education Institute ACTA, Gustav Mahlerlaan 3004 1081 LA Amsterdam Tel: +31-20-5980438 E-mail: [email protected]

Research objectives In the ACTA faculty of Dentistry research is performed on several aspects of education in dentistry. This includes research on the evaluation of courses and performance of students within the curriculum, research on new teaching methods, development and evaluation of a computer aided digital teaching system creating a virtual learning environment including the application of haptics (the Simodont Dental Trainer). Also some projects are carried out on assessment of the safety of the learning environment and the effect of interventions. The input of academic personnel is limited to staff of the educational institute, and to some members of the various departments. The research is not considered as a separate programme; however it is intended that this research will increase in the coming years.

Results In 2016 again several experiments have been carried out with respect to choices in the development of the virtual dental trainer. It appeared that availability of force feedback (FFB) in a dental trainer is essential for good performance but some variance in FFB is acceptable for learning. Data on inter and intra observer reliability of assessment showed that including calibration in the workflow of an assessment procedure improved the reliability of the assessments till a certain extend, after that calibration did not further affect the interreliability. Students that were able to perform well in reality are also able to perform in VR; a longer learning curve in Reality does not seem to result in a longer learning curve in VR. Giving students freedom to decide on their testing moment for Manual Dexterity provides better result on these tests than when the test date is fixed by the school.

Academic personnel in 2016 Position Name 2016 funding Vervoorn, dr. J.M. 0,10 1 Staff members education institute Wesselink, prof.dr. P.R. pm guest Bakker, drs. D.R. 0,10 3 PhD students Boer, drs. I.R. de 0,20 1 Serrano Petrillo, dds. C.M. 0,15 3 total 1st funding 0,30 1 total 3rd funding 0,25 3 Total research staff 0,55

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Output Scientific publications (refereed) De Boer, I.R., Wesselink, P.R. & Vervoorn, J.M. (2016). Student performance and appreciation using 3D vs. 2D vision in a virtual learning environment European Journal of Dental Education, vol 20, no. 3, pp. 142-147. DOI: 10.1111/eje.12152

Professional publications Van der Zande, MM, Gorter, R.C., Wismeijer, D. & van der Heijden, G.J.M.G. (2016). Vernieuwingen in de praktijk.: Rubriek Uitgelezen Nederlands Tandartsenblad, vol 71, no. 14, pp. 18.

Indicators of Esteem

Scientific awards Serrano Petrillo, C.M. (August 24-26, 2016). 40th Anniversary Scholarship award 2015-2016. ADEE Annual Conference: Barcelona, Spain.

Memberships editorial board Gorter, R.C.: European Journal of Dental Education.

Invited speakers at (inter)national congresses or symposia Koopman, P.G., Wesselink, P.R. & Vervoorn, J.M. (April 24-25, 2016). Virtual reality in dental patients. International Symposium on Virtual Reality in Dental Training, Chengdu, China.

Other (inter)national scientific functions Gorter, R.C.: Executive board member Association for Dental Education in Europe (ADEE), since 2013. Gorter, R.C.: Member Platform for better oral health in Europe. Serrano Petrillo, C.M. Chair Special Interest Group: Transition to Clinical Training in Dentistry. Vervoorn, J.M.: Chair Simodont Forum ADEA/ADEE. Vervoorn, J.M.: Chair special interest group ADEE: Virtual reality in dental education, since 2009. Wesselink, P.R.: Chair special interest group ADEE: Virtual reality in dental education, since 2009.

Current PhD projects Bakker, DR. Transfer of skills between virtual reality and reality in dental education. Supervisor: prof.dr. P.R. Wesselink; co-supervisor: dr. J.M. Vervoorn. Start: 2010-11. De Boer, IR. Acceptance of new technologies in dental education. Supervisor: prof.dr. P.R. Wesselink; co- supervisor: dr. J.M. Vervoorn. Start: 2010-11. Serrano Petrillo, CM. Bridging the gap between preclinical and clinical training in dental education. Supervisor: prof.dr. C. van Loveren; co-supervisor: dr. J.M. Vervoorn. Start: April 2015.

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Societal impact The societal impact of the research and development is focused on the effect of learning behaviour on learning outcomes and on the implementation of new technologies in education. Also developments have an increased focus on improving safety of the learning experience. This involves in particular the developments of virtual exercise on a digital impression of the patient in advance of the actual clinical procedure using a computer aided digital learning environment (the Simodont dental trainer).

I. Societal relevance for the dental professional in the Netherlands

Interactions and collaborations with the industry and other non-university groups MOOG inc. Development of the Simodont dental trainer. 3M – Development of real scans into virtual reality application.

Courses organized for Dutch dental and medical professionals Bakker, D.R., de Boer, I.R. & Serrano Petrillo, C.M. (April 2 - 23 & September 3 – 24, 2016). Herregistratie Tandartsen NL. Gorter, R.C. (April 2 - 23 & September 3 – 24, 2016). Herregistratie BIG voor tandartsen: ACTA, Amsterdam. Wesselink, P.R. & Vervoorn, J.M. (June 5-6, 2016). Quality Assurance in Clinical Dental Training, Poznam, Poland.

Professional functions in the Netherlands Gorter, R.C.: Vervangend lid Algemene Interfacultaire Ethische Commissie UvA. Vervoorn, J.M.: Chair Simodont Users Meetings.

II. Societal relevance for the dental professional internationally

Professional functions internationally Vervoorn, J.M.: External Examiner Leeds Dental Institute.

104 Appendix

List of SCI journals, their impact factors and the number of ACTA publications in 2016 in each journal

Journal IF Number of Journal IF Number of publications publications ACTA PAEDIATR 1,647 1 J CELL BIOCHEM 3,446 1 ADV EXP MED BIOL 1,953 1 J CELL PHYSIOL 4,155 2 ALTEX-ALTERN ANIM EX 5,712 1 J CLIN PEDIATR DENT 0,562 2 AM J DENT 1,194 1 J CLIN PERIODONTOL 3,915 4 AM J PATHOL 4,206 1 J CRANIOFAC SURG 0,700 1 ANN BIOMED ENG 2,887 1 J CRANIO MAXILL SURG 1,592 5 ANTIMICROB AGENTS CH 4,415 1 J DENT RES 4,602 2 ARCH CLIN NEUROPSYCH 2,014 1 J DENT 3,109 3 ARCH ORAL BIOL 1,733 2 J EMERG MED 1,048 1 ARTHRITIS RES THER 3,979 1 J ENDODONT 2,904 5 AUGMENT ALTERN COMM 2,960 1 J EPIDEMIOL COMMUN H 3,865 1 BEHAV NEUROL 1,629 1 J EVID-BASED DENT PR 1,474 1 BIOCONGUJATE CHEM 4,500 1 J HUM HYPERTENS 2,833 1 BIOFOULING 3,000 1 J IMMUNOL METHODS 1,858 1 BIOINFORMATICS 5,766 1 J IMMUNOL RES 2,812 1 BIOMECH MODEL MECHAN 3,032 1 J INNATE IMMUN 4,273 1 BMC ORAL HEALTH 1,210 6 J INTELLECT DEV DIS 0,892 1 BMJ OPEN 2,562 2 J LEUKOCYTE BIOL 4,165 1 BONE 3,736 3 J MECH BEHAV BIOMED 2,876 4 BRIT DENT J 0,997 3 J NEUROSCI METH 2,053 1 BRIT J CANCER 5,569 1 J ORAL MAXIL SURG 1,631 3 BRIT J ORAL MAX SURG 1,237 2 J ORAL MICROBIOL 3,421 2 BRIT J PSYCHIAT 7,060 2 J ORAL PATHOL MED 1,859 1 BRIT J SPORT MED 6,724 1 J ORAL REHABIL 1,926 10 CALCIFIED TISSUE INT 3,052 2 J PERIODONTAL RES 2,474 1 CANCER IMMUNOL IMMUN 4,846 1 J PERIODONTOL 2,844 1 CARIES RES 2,278 3 J PLANT PHYSIOL 2,971 1 CELL TISSUE RES 2,948 1 J PROSTHET DENT 1,515 2 CELLS TISSUES ORGANS 1,228 1 J PSYCHOPHARMACOL 3,637 1 CELL TRANSPLANT 3,427 1 J PUBLIC HEALTH 1,527 1 CHEMBIOCHEM 2,850 1 J RECONSTR MICROSURG 1,734 1 CLEFT PALATE-CRAN J 1,050 1 J STEROID BIOCHEM 3,985 2 CLIN NUCL MED 4,278 1 J STRUCT BIOL 2,570 1 CLIN ORAL IMPLAN RES 3,464 1 LASER MED SCI 2,461 1 CLIN ORAL INVEST 2,207 4 MACROMOL BIOSCI 3,680 1 COCHRANE DB SYST REV 6,103 1 MAT SCI ENG C MATER BIOL APPL 3,420 1 COMMUNITY DENT ORAL 2,233 1 MEDICINE 2,133 1 CONNECT TISSUE RES 1,411 1 METABOLOMICS 3,661 1 CONTACT DERMATITIS 5,692 1 MICROB ECOL 3,232 1 CURR OSTEOPOROS REP 2,890 1 MICROGRAVITY SCI TEC 0,725 4 DENT MATER 3,931 2 ODONTOLOGY 1,583 3 DENTOMAXILLOFAC RAD 1,990 2 ONCOGENE 7,932 1 DEPRESS ANXIETY 5,004 1 OPER DENT 2,819 2 DRUG DISCOV TODAY 5,625 1 OPHTHALMIC GENET 1,89 1 EUR ARCH OTO-RHINO-L 1,627 9 ORAL ONCOL 4,286 3 EUR J DENT EDUC 2,784 2 OR SURG OR MED OR PA 1,262 5 EUR J ORAL SCI 1,607 1 OSTEOARTHR CARTILAGE 4,535 1 EUR J PAEDIATR DENT 0,421 1 OSTEOPOROSIS INT 3,445 1 EUR J PAIN 2,900 1 PATHOG DIS 2,483 1 EUR J PSYCHOTRAUMATO 1,791 2 PEDIATR DENT 0,800 1 FAM PRACT 2,022 1 PERIODONTOL 2000 4,949 1 FRONT NEUROSCI 3,400 1 PLOS ONE 3,057 10 GERODONTOLOGY 1,396 2 P NATL ACAD SCI USA 9,423 1 HEAD & NECK 2,760 4 PSYCHOL MED 5,491 1 IMPLANT DENT 1,023 2 QUINTESSENCE INT 0,821 2 INJURY 1,910 1 SCHIZOPHRENIA BULL 7,757 1 INNATE IMMUN 2,830 1 SCHIZOPHR RES 4,453 1 INT ENDOD J 2,842 1 SCI REP 5,228 3 INT J ADHES ADHES 1,956 1 SLEEP BREATH 2,332 2 INT J DENT HYG 0,791 4 SLEEP MED 3,339 1 INT J MOL MED 2,348 1 STEM CELLS INT 3,687 3 INT J MOL SCI 3,257 3 STEM CELL TRANSL MED 4,247 1 INT J ORAL MAX SURG 1,563 2 SUPPORT CARE CANCER 2,535 3 INT J ORAL MAX IMPL 1,859 3 SURG ENDOSC 3,540 1 INT J ORAL SCI 2,595 1 THER CLIN RISK MANAG 1,903 1 INT J PAEDIATR DENT 1,303 2 TISSUE ENG PART C METH 3,892 1 INT J PROSTHODONT 1,487 2 TRENDS BIOTECHNOL 12,065 1 ISR J CHEM 2,425 1 TRIALS 1,859 1 J BIOMATER TISS ENG 1,287 1 VET RES 2,928 1 J BIOMECH 2,431 2 WORLD J MICROB BIOT 1,532 1 J BIOMED MATER RES B 2,881 1 WOUND REPAIR REGEN 2,628 1

total 254

Annual Research Report 2016

Name Index

Name Page Name Page Aarab, dr. G. 63 Cai, dds. Y. 21 Aartman, dr. I.H.A. 20 Calixtre, L.B. 63 Abdel Aziz, dds. M.F.A. 65 Campos, dds. F. 63 Akveld, MSc. N.A.E. 21 Cao, MSc. Y. 65 Al Hothali, dds. M.M. 21 Castro Morais Machado, G. de 22 Al Jamaei (Sahar), dds. A.A. 21 Cate, prof.dr. J.M. ten 20 Al Kurwi A. 63 Chalil, dds. S. 65 Algera, dr. T.J. 63 Chen, dds. H. 65 Alharbi, dds.N.M. 65 Cioccari Oliveira, dds. S. 63 Amiri Bavandour, M. 63 Couturier, drs. E.G.M. 65 Anssari Moin, drs. D. 21, 65 Crielaard, prof.dr. W. 20 Apperloo, drs. R.C. 63 Daher, dds. R. 65 Asikainen, drs. P.J. 65 Damaskos, dr. S. 63 Baâdoudi, MSc. F. 21 Danser, dr. M. 63 Baaij, drs. A. 21 Dekker, dr. J., den 21 Baar, drs. G.J.C., van 63 Dekker, drs. H. 22 Baart, drs. J.A. 63 Delatola, dds. C. 22 Baggen, drs. J.H.M. 65 Delwel, drs. S. 65 Bakker, dr. A.D. 62 Deng, dr. D.M. 21 Bakker, drs. D.R. 102 Derksen, drs. W.D.C. 65 Baravordeh, F. 63 Diermen, dr. D.E. van 21 Bastidas Coral, dds. A.P. 65 Dijk, drs. S., van 22 Becking, prof.dr. A.G. 62 Dijk, MSc. I.A., van 22 Beerens, drs. M.W. 65 Disse, drs. M.A. 63 Bergh, dr. B., van den 65 Donders, drs. H.C.M. 22 Berkhout, dr. W.E.R. 63 Dubois, drs. L. 63 Betti, MSc. B.F. 65 Duijster, dr. D. 21 Bikker, dr. F.J. 20 Eekeren, drs. P.J.A. van 65 Bizzarro, dr. S. 20 Eijkman, prof. dr. M.A.J. 20 Bloemena, prof.dr. E. 20 Eijnatten, MSc. M. van 65 Boer, drs. I.R. de 102 Elkerbout, MSc. T.A. 22 Böhmer, MSc. K.L. ten 21 Elyassi, MSc. Y. 63 Boink, MSc. M.A. 21 Engels, E. 63 Bollen, K. 63 Entezami Rad, drs. N. 63 Bolscher, dr. J.G.M. 20 Esposito, dds. S.A. 22 Bonifacio, dr. C.C. 21 Esterik, MSc. F.A.S. van 65 Bontkes, dr. H.J. 63 Evans, dds. C. 65 Bos, dr. A. 63 Everaars, MSc. B. 22 Bosch, M. van den 63 Everts, prof.dr. V. 62 Bots- van 't Spijker, drs. P.C. 22 Farhanghi, R. 63 Bots, dr. C.P. 21 Farré-Guasch, dr. E. 63 Boutsioukis, dr. C. 21 Fazaeli, MSc. S. 65 Bouwman, drs. W.F. 65 Feilzer, prof.dr. A.J. 62 Brand, dr. H.S. 21 Flügge, dds. T.V. 64 Brandt, dr. B.W. 21 Forouzanfar, prof.dr. T. 20, 62 Broers, drs. D.L.M. 22 Fraga, dds. S. 64 Bronckers, dr. A.L.J.J. 62 Gambon, dr. D.L. 21 Bruers, prof.dr. J.J.M. 20 Geraets, dr. W.G.M. 63 Bruggeman, dr. J. P. 63 Geurs, MSc. N.C. 22 Bruggenkate, prof.dr. C.M. ten 62 Gibbs, prof.dr. S. 62 Buskermolen, MSc. J.K. 65 Gilijamse, drs. M. 64

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Name Page Name Page Gimenez, dds. B. 64 Kleverlaan, dr. C.J. 62 Göbel, drs. J.C. 64 Knibbe, drs. W. 64 Goené, drs. R.J. 63 Kok, drs. P. de 63 Gorter dr. R.C. 20 Kommers, MSc. S.C. 65 Graaf, MSc. N.P.J. de 65 Koolstra, dr.ir. J.H. 62 Gregor, dds. L. 65 Koopman, drs. J.E. 22 Grootel, drs. R.J. van 65 Koppelmans, MSc. R.G.A. 22 Gunput, MSc. S.T.G. 22 Koutris, dr. M. 63 Han, dds. Q. 21 Kraaij, MSc. S. 22 Hansenova Manaskova, MSc. S. 22 Kramer, dr. G.J.C. 64 Harkel, MSc. B. ten 65 Krom, dr. B.P. 20 Hassan, dr. B.A. 63 Kuijs, R.H. 64 Hattem, A.B. 64 Kuik, drs. K. 65 Haverman, MSc. T.M. 22 Kuitert, dr. R.B. 62 Heidsieck, drs. D.S.P. 65 Lagerweij, dr. M.D. 21 Heijden, prof.dr.G. J.M.G. van der 20 Laheij, dr. A.M.G.A. 21 Helder, dr. M.N. 62 Laine, dr. M.L. 20 Helmer, L. 64 Lange prof.dr. J. de 20, 62 Helmers, drs. R. 22 Langenbach, dr. G.E.J. 62 Hemmatian, dds. H. 65 Liao, dds. Y. 22 Hendra, dds. F.N. 22 Ligtenberg, dr. A.J.M. 21 Hermus, R.R. 64 Lin, dds. X. 64 Hertog, drs. D. 22 Lindeboom, dr. J.A.H. 21 Hesse, dr. D. 21 Liu, dds. H. 21 Ho, dds. B.V. 65 Liu, dds. Y. 64 Ho, MSc. J.P.T.F. 22 Liu, dr. Y. 63 Hoekema, dr. A. 62 Lobbezoo, prof.dr. F. 62 Hol, drs. M.L.F. 65 Loon, dr. J.J.W.A. van 64 Hoogeveen, MSc. R.C. 64 Loos, prof.dr. B.G. 20 Houtem, dr. C.M.H.H. van 22 Lourenco, dds. A.L.R. 65 Houwing, drs. M. 65 Louropoulou, dds. A. 22 Hummel, drs. G.I. 22 Loveren, prof.dr. C. van 20 Imangaliyev MSc. S. 22 Maarse, MSc. F. 64 Iskender, S.Y. 64 Maningky, drs. M.S. 65 Jager, dr. D.H.J. 21, 64 Marpaung, dds. C.D. 65 Jager, dr.ir. N. de 63 Maskrey, MD. N. 21 Jalali, dds. R. 65 Matse, drs. J.H. 22 Janus, ir. M.M. 22 May, MSc. A. 22 Jong, MSc. B.G. de 22 Meer, H.A. van der 64 Jong, MSc. T. de 65 Meijer, drs. B.A. 64 Jongh, prof.dr. A. de 20 Melo Avila, dds. W. de 22 Jong-Lenters, drs. M. de 22 Mendrik, dr. A.N. 64 Jongsma, dr. L.A. 63 Mevissen-Renckens, drs. E.H.M. 22 Joosten, M.W. 64 Milbradt Dutra, dds. D.A. 64 Kaaij, drs. N.C.W. van der 65 Milstein, dr. D.M.J. 21 Kapagiannidou, drs. D. 64 Mirahmadi, MSc. F. 65 Kaper, N. 22 Moghimi, drs. M. 22 Karagozoglu, drs. K.H. 21 Moinzadeh, dr. A.T. 21 Karssemakers, drs. L.H.E. 65 Mokhtari-Jafari, dds. F. 65 Keijser, prof.dr.ir. B.J.F. 20 Moonen, MSc. C.G.J. 22 Kelder, MSc. C.L. 65 Müncker, ir. T.J.A.G. 65 Klein Nulend, prof.dr. J. 62 Muris, dr. J. 63

107 Annual Research Report 2016

Name Page Name Page Muzalev, drs. K.S. 65 Serrano Petrillo, dds. C.M. 102 Natsir Kalla, dds. D.S. 65 Shang, MSc. L. 22, 66 Neelakantan, dds. P. 22 Shemesh, dr. H. 20 Nes, MSc. K.A. van 21 Sijbrandij, MSc. T. 22 Nicu, dr. E.A. 21 Sleen, drs. J.C. van der 66 Nijkamp, P.G. 64 Slot dr. D.E. 21, 63 Nikolopoulou, drs. M. 65 Sluijs, MSc. E. van der 23 Nolte, drs. J.W. 66 Smeele, prof.dr. L.E. 20 Nolte, F.M. 64 Soet, dr. J.J. de 20 Oey, C. 64 Soffner, M. 64 Oomens, drs. M.A.E.M. 66 Sprangers, MSC. S.L. 66 Oosterhuis, M. 64 Steegman, drs. J. 23 Özen, dr. B. 21 Steegmans, P. 64 Özok, dr. A.R. 21 Steenbergen, dr. T.J.M. van 20 Padmos, J. 64 Steenen, drs. S.A. 23 Papagianni, C. 21, 64 Stelt, prof.dr. P.F. van der 62 Papantonopoulos, dds. G.H. 22 Story, drs. J.J.P. 64 Parvaneh, drs. D. 64 Strijp, dr. A.J.P. van 20 Pereira, dds. G. 64 Su, dds. N. 23 Persoon, MSc. I.F. 22 Sun, dds. W. 23 Poorterman, dr. J.H.G. 63 Tabeian, MSc. H. 66 Prahl, dr. C. 63 Tahmaseb, dr. A. 63 Prodan, MSc. A. 22 Tan, drs. C.W.X. 23 Raber-Durlacher, dr. J.E. 21 Tastepe, dds. C.S. 66 Rademacher, MSc. W.M.H. 22 Täubock, drs. T.T.K.J. 66 Raghav, dds. K. 22 Teeuw, MSc. W.J. 23 Ramdat Missier, R.H. 64 Teng, dds. F. 66 Ras, F. 64 Thymi, drs. M. 66 Ravesloot, prof.dr. J.H. 62 Tuijt, drs. M. 66 Renders, drs. G.A.P. 66 Tuinzing, prof.dr. D.B. 62 Restrepo Serna, drs. C.C. 66 Tuk, drs. J.C. 23 Reyes Sevilla, drs. M. 64 Uijlenbroek, drs. H.J.J. 66 Ridwan, drs. A. 66 Vahed, MSc. F. 64 Rijkschroeff, MSc. P. 22 Veen, dr.ir. M.H. van der 20 Roeters, prof.dr. F.J.M. 62 Veerbeek, drs. H.J. 23 Rollman, dr. A. 64 Veerman, prof.dr. E.C.I. 20 Roos, drs. C.J.A.M. de 22 Vehmeijer, drs. M.J.J.B. 64 Roseboom, drs. H.J. 22 Velden, prof.dr. U. van der 20 Rosema, dr. N.A.M. 21 Veldhuizen, MSc. R. 66 Rozeboom, drs. A.V.J. 66 Velzen, drs. F.J.J. van 66 Rozema, prof.dr. F.R. 20 Verheij, dr. J.G.C. 63 Ruiter, drs. M.H.T. de 66 Verhulst, MSc. J.M.L. 23 Ruslin, dds. M. 66 Verlinden, drs. C.R.A. 66 Salentijn, drs. E. 66 Verrips, prof.dr. G.H.W. 20 Sälzer, dr. S.A. 22 Verstraaten, mw. S. 23 Sanderink, dr. G.C.H. 63 Vervoorn, dr. J.M. 102 Scheerman, MSc. J.F.M. 22 Vijfeijken, drs. S.E.C.M. van der 66 Scholtanus, drs. J.D. 66 Visscher, dr. C.M. 63 Schreuder, drs. W.H. 22 Visscher, dr. J.G.A.M. de 21 Schreurs, drs. R. 66 Vliet, drs. N.I. van 23 Schulten, prof.dr. E.A.J.M. 20, 62 Vogels, drs. M.P.J.M. 23 Selms, dr. M.K.A. van 63 Volgenant, dr. C.M.C. 23, 64

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Name Page Name Page Voskuilen, MSc. L. 23 Wouden, drs. P. van der 23 Vries, dr.ir. T.J. de 21 Wu, dr. G. 63 Vries, MSc. M.W. de 23, 66 Yang, dds. Y. 21 Vries, prof.dr. N. de 62 Yonel, dr. N. 64 Waal, drs. S.V. van der 23 Zamani, dds. Y. 66 Wang, dds. D. 66 Zande, MSc. M.M. van der 23, 66 Warnsinck, C.J. 63 Zandieh Doulabi, dr.ing. B. 64 Weijden, prof.dr. G.A. van der 20 Zardo Trindade, dr. F. 64 Weijenberg, dr. R.A.F. 64 Zaura, dr. E. 20 Weinberg, MSc. F.M. 23 Zecha, drs. J.A.E.M. 23 Wesselink, prof.dr. P.R. 20, 102 Zembic, dds. A. 66 Wetselaar, drs. P. 64 Zemouri, MSc. C. 23 Wezel, N. van 64 Zentner, prof.dr. A. 62 Widyahening, I. 23 Zhang, dds. X. 66 Wijk, dr. A.J. van 20 Zhao, dds. S. 23 Wismeijer, prof.dr. D. 62 Ziukaite, MSc. L. 23 Wolff, dr. J.E.H. 64 Zygogiannis, dds. K. 66

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