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Chemical Properties Biological Description Solubility Data Sheet (Cat.No.T4412) Roquinimex Chemical Properties CAS No.: 84088-42-6 Formula： C18H16N2O3 Molecular Weight： 308.34 Appearance： N/A Storage： 0-4℃ for short term (days to weeks), or -20℃ for long term (months). Biological Description Description Roquinimex (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha. Targets(IC50) Others: None In vivo Prophylactic administration of DSS-treated mice with roquinimex significantly reduced clinical signs of colitis, MDS and the CH-reduction. Moreover, in roquinimex treated animals, the MPO activity was significantly reduced by more than 50% compared to DSS control mice. Notably, therapeutic administration of roquinimex in DSS-treated mice also significantly inhibited the MDS, CH-reduction and MPO activity. Linomide, a synthetic immunomodulator, at concentrations effective in vivo reduces the number of MBP-reactive TNF-alpha and increases MBP-reactive IL-10 and TGF-beta mRNA expressing MNC from MS patients' blood when analysed in vitro. Compared to dexamethasone, Linomide up-regulated levels of blood MNC expressing mRNA of TGF-beta after culture in presence of MBP Solubility Information Solubility DMSO: 83.3 mg/mL (270.17 mM) (< 1 mg/ml refers to the product slightly soluble or insoluble) Preparing Stock Solutions 1mg 5mg 10mg 1 mM 3.243 mL 16.216 mL 32.432 mL 5 mM 0.649 mL 3.243 mL 6.486 mL 10 mM 0.324 mL 1.622 mL 3.243 mL 50 mM 0.065 mL 0.324 mL 0.649 mL Please select the appropriate solvent to prepare the stock solution, according to the solubility of the product in different solvents. The storage conditions and period of the stock solution: - 80 ℃ for 6 months; - 20 ℃ for 1 month. Please use it as soon as possible. Reference 1. Liu Q,etal. Roquinimex inhibits dextran sodium sulfate-induced murine colitis.Inflamm Res. 2003 Feb;52(2):64-8. 2. Tian WZ,etal.Linomide (roquinimex) affects the balance between pro- and anti-inflammatory cytokines in vitro in multiple sclerosis.Acta Neurol Scand. 1998 Aug;98(2):94-101. Page 1 of 2 www.targetmol.com A DRUG SCREENING EXPERT Inhibitors · Natural Compounds · Compound Libraries This product is for Research Use Only · Not for Human or Veterinary or Therapeutic Use. Tel:781-999-4286 E-mail:[email protected] Address:36 Washington Street,Wellesley Hills,MA 02481 Page 2 of 2 www.targetmol.com.
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