DOCSLIB.ORG

(12) United States Patent (10) Patent No.: US 8,697,347 B2

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
(12) United States Patent (10) Patent No.: US 8,697,347 B2 USOO8697347B2 (12) UnitedO States Patent (10) Patent No.: US 8,697,347 B2 Sehgal (45) Date of Patent: *Apr. 15, 2014 (54) COMPOSITION FOR PRESERVING OTHER PUBLICATIONS PLATELETS AND METHOD OF USING THE SAME Furman et al., “GPllb-Illa Antagonist-induced Reduction in Platelet Surface Factor ViVa Binding and Phosphatidylserine Expression in (75) Inventor: Lakshman R. Sehgal, Monarch Beach, Whole Blood”. Thromb. Haemost. 84: 492-8 (2000).* CA (US) Uzan, 'Antithrombotic agents'. Chapter 12, Emerging Drugs 3 : 189-208 (1998).* (73) Assignee: Biovec Transfusion, LLC, Chicago, IL Agranenko et al., “Preparing platelet concentrates from banked blood (US) stored for 1-5 days by using tetracycline antibiotics”. Folia Haematologica 110 (6): 879-86 (1982), abstract only.* ( c ) Notice: Subject to any disclaimer, the term of this International Search Report (Application No. PCT/US2003/038.125, patent is extended or adjusted under 35 filed Dec. 2, 2003). U.S.C. 154(b) by 300 days. Abendschein. D.R., et al., “Effects of ZK-807834, a Novel Inhibitor of Factor Xa, on Arterial and Venous Thrombosis in Rabbits', J. This patent is Subject to a terminal dis- Cardiovasc. Pharmacol., vol. 35. No. 5, pp. 796-805, retrieved Oct. claimer. 11, 2006, <http:\\gateway.ut.ovid.com.gwllovidweb.cgi>, May 2000. (21) Appl. No.: 13/098,128 Ostrem, JA, et al., “Discovery of a Novel, Potent, and Specific Family of Factor Xa Inhibitors via Combinatorial Chemistry, Biochemistry, (22) Filed: Apr. 29, 2011 vol. 37, No. 4, pp. 1053-1059, 1998. Hirsh, J. et al., “New antithrombotic agents'. The Lancet, vol. 353, (65) Prior Publication Data pp. 1431-1436, Apr. 24, 1999. Pinto, Donald J.P. et al., “Discovery of 1-3-(Aminomethyl)phenyl US 2011 FO223663 A1 Sep. 15, 2011 N-3-fluoro-2'-(methylsulfonyl)-1, 1'-biphenyl-4-yl)-3- (trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly O O Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagul Related U.S. Application Data lation Factor Xal'. J. ME vol. 44, pp. 566-578, ise (63) Continuation of application No. 1 1/330,132, filed on Pruitt, James R. et al., “Isoxazolines and Isoxazoles as Factor Xa Jan. 12, 2006, now Pat. No. 7.964.338. Inhibitors'. Bioorg. Med. Chem. Lett., vol. 10, pp. 685-689, (2000). s s s- Y is Quan, Mimi L. et al., “Design and Synthesis of Isoxazoline Deriva (60) Provisional application No. 60/643,107, filed on Jan. tives as Factor Xa Inhibitors'.J.Med. Chem... vol.42, pp. 2752-2759, 12, 2005. (1999). Sato. K. et al. “Relationship between the antithrombotic effect (51) Int. Cl. ofYM-75466, a novel factor Xa inhibitor, and coagulationparameters AOIN I/02 (2006.01) in rats'. European Journal of Pharmacology, vol. 347, pp. 231-236. (52) U.S. Cl. ().ong, P.C., et al., “Non& 8 peptide Factor Xa. Inhibitors:1- Faro, I. Studies with USPC .............................................................. 435/2 SF303 and SK549, a New Class of Potent Antithrombotics', The (58) Field of Classification Search Journal of Pharmacology and Experimental Therapeutics, vol. 292, None No. 1, pp. 351-357, (2000). See application file for complete search history. Fareed, J. et al., “New antithrombotic drugs: A perspective'. Current Opinion in Cardiovascular, Pulmonary & Renal Investigational (56) References Cited Drugs, vol. 1, No. 1, pp. 40-55, (1999). Mousa, S. et al., “Vasoactive Role of the aWll3 iNtegrin in Rabbit U.S. PATENT DOCUMENTS Carotid Artery: Endothelium-Dependent and Independent Effects' Abstracts from the 71st Scientific Sessions, No. 179, pp. 1-37, 4,455.299 A * 6/1984 Grode ........................... 424,532 Undated. 4,800,016 A 1/1989 Yang 5,256.559 A * 10/1993 Maraganore et al. ... 424,153.1 (Continued) 5,798.238 A 8/1998 Goodrich, Jr. et al. 5,801,063 A 9, 1998 Grandics et al. Primary Examiner — Sandra Saucier 3.35 A 38 M. al. (74) Attorney, Agent, or Firm — Ping Wang: Andrews Kurth, 5,919,614 A * 7/1999 Livesey et al. .................... 435/2 LLP 5,955,256 A 9, 1999 SOwenimo-Coker et al. 5,981,163 A 11/1999 Horowitz et al. (57) ABSTRACT 6,030,767 A 2/2000 Wagner et al. 6,087,141 A 7/2000 Margolis-Nunno et al. The present invention relates to compositions and methods 6,106,773. A 8, 2000 Miekka et al. for storing platelets to preserve the function and freshness of 6,733,471 B1 5/2004 Ericson et al. the platelets. More particularly, the present invention relates 8373 R ck 1239 insta . 530/402 to the use of a preservative composition having an antiplatelet 7.964.338 B2 * 6/2011 Sehgal et al. ..................... 435.2 agent, an anticoagulant, and an oxygen carrier, for maintain 8,129.103 B2 * 3/2012 Sehgal et al. .. ... 435.2 ing the freshness of platelets. Additionally, the composition 8,129,104 B2 * 3/2012 Sehgal et al. .. ... 435.2 may also contain an ultra-short acting broad spectrum anti 8,142,992 B2 : 3/2012 Sehgal et al. ... 435.2 microbial agents. The preservative composition may be used 200 of: R ck 3i E, Ogosi to store platelets in a liquid state, a frozen state, or a freeze 2004/0223957 A1 11/2004 Lucas et al. dried state. 2008. O138791 A1 6, 2008 Hoffmeister et al. 2010, 0221697 A1 9/2010 Sehgal 18 Claims, 3 Drawing Sheets US 8,697,347 B2 Page 2 (56) References Cited Notification of Transmittal of the International Search Report and the Written Opinion of the International Searching Authority of Interna OTHER PUBLICATIONS tional Application No. PCT/US2011/025432 dated Dec. 29, 2011. Kon, T., et al., “Bone Morphogenetic Protein-2 Stimulates Differen tiation of Cultured Spinal Ligament Cells from Patients with Ossifi Herbert, J.M., et al., “DX 9065A, a Novel, Synthetic, Selective and cation of the Posterior Longitudinal Ligament”. Calcified Tissue Orally Active Inhibitor of Factor Xa. In Vitro and InVivo Studies'. International, vol. 60, pp. 291-296 (1997). (abstract and first page The Journal of Pharmacology and Experimental Therapeutics, vol. only). 276, No. 3, pp. 1030-1038, (1996). International Search Report (Application No. PCT/US2007/006371, Nagahara, T. et al., “Design, Synthesis and Biological Activities of filed Mar. 14, 2007). International Search Report (Application No. PCT/US2009/034289, Orally Active Coagulation Factor Xa. Inhibitors'. Eur, J. Med. Chem. filed Feb. 17, 2009). vol. 30 (Supplemental), pp. 140s-143s, (1995). International Search Report (Application No. PCT/US2010/037203, Ewing, W.R., et al., “Progress in the design of inhibitors of coagula filed Jun. 3, 2010). tion factor Xa'. Drugs of the Future, vol. 24. No. 7, pp. 771-787, Written Opinion of the International Search Authority (Application (1999). No. PCT/US2010/037203, filed Jun. 3, 2010). Al-Obeidi. F., et al., “Factor Xa inhibitors'. Exp. Opin. Ther. Patents, Wikipedia, “Eptifibatide', pp. 1-3, downloaded Mar. 11, 2011. vol. 9, No. 7, pp.931-953, (1999). Gao, C et al., “Eptifibatide-induced thrombocytopenia and Krishnamurti, C., et al., “Reduction of blood loss by infusion of thrombosis in humas require FcyRlla and the integrin f33 cytoplasmic human platelets in a rabbit kidney injury model”. Transfusion, vol. domain'. The Journal of Clinical Investigation, Mar. 2009, vol. 39, pp. 967–974, (Sep. 1999). 11(3):504-511. Mousa, SA, et al., “Comparative InVitro Efficacy of Different Plate Gerbutavicius, R. et al., “Differential effects of DX-9065a, let GPll/b/ilia Antagonists on the Dynamic of 14 Platelet I Fibrin argatroban, and synthetic pentasaccharide on tissue thromboplastin Mediated Clot Strength Induced by Different Mediators. Using inhibition test and dilute Russell's viper venomtest”, (Abstract only) Thromboelastography: Differential Efficacy”. Running title: “Plate Clin. Appl. Thromb. Hemost. (Oct. 9, 2003)4, 317-323. let GPllb/lla and PlatelellFibrin Clot Retraction', (Paper submitted) Beilfu, A et al., “Differential Effects of Factor lla Inhibitors on the pp. 1-21. Undated. Endogenous Thrombin Potential”. Therapeutic Drug Monitoring, Supplementary European Search Report dated Oct. 27, 2011 of Inter Dec. 2008, vol. 30(6):740–743. (Abstract). national Application No. 06718042.2. WarnholTZ. Ascan, et al., “Vasoactive Role of the aW1b3 iNtegrin in Bode, A., et al., “Extended Storage of Platelets in an Artificial Rabbit Carotid Artery: Endothelium-Dependent and Independent Medium with the Platelet Activation Inhibitors Prostaglandin E1 and Effects', American Heart Association, 71st Scientific Sessions, Nov. Theophylline'', Vox Sang, 1991, No. 60, pp. 105-112. 8-11, 1998. Leytin, V. et al., “Hemolink, an o-raffinose cross-linked Mousa, Shaker A. et al., "Comparison of the Effect of Different haemoglobin-based oxygen carrier, does not affect activation and Platelet GPllbilla Antagonists on the Dynamics of Platelet/Fibrin function of human platelets in whole blood in vitro”, (Abstract only), Mediated Clot Strength Induced Using Thromboelastography”. Brit J Haemetology (2003), 120 (3), 535-541. Thrombosis Research, Jul. 3, 2001, vol. 104, pp. 49-56. Friesch, T. et al., “Artificial oxygen carriers’. European Journal of Anaesthesiology, vol. 15, 1998, pp. 571-584. * cited by examiner U.S. Patent Apr. 15, 2014 Sheet 1 of 3 US 8 9697,347 B2 87][50]=| ERHIWANOIS?HO_L U.S. Patent Apr. 15, 2014 Sheet 2 of 3 US 8,697,347 B2 EFFECT OF b/a ANTAGONST C7E3 ON TISSUEFACTOR MEDIATED CLOT RETRACTION INHUMAN WHOLE BLOOD THROMBOELASTOGRAPHY TF4 g/ml FIG 2A C7E3 29 nM 58 nM 116 nM 42 3 AM FIG 2B 60 20 --O-AGGREGATIONIC50=79nM -HTEGIC50= 68nM FIG 2C U.S. Patent Apr. 15, 2014 Sheet 3 of 3 US 8,697,347 B2 ?NICINIGNEÐONIHgI4-lgzy +ISINOÐVLNVvº) CJOOTEETOHNA ‘SHHZ<| US 8,697,347 B2 1. 2 COMPOSITION FOR PRESERVING this short shelf-life is that platelets must be collected close to PLATELETS AND METHOD OF USING THE their time of use, which makes it extremely difficult to coor SAME dinate platelet collection and platelet Supply.
Load more

Recommended publications
  • Antithrombotic Treatment After Stroke Due to Intracerebral Haemorrhage (Review)
    Cochrane Database of Systematic Reviews Antithrombotic treatment after stroke due to intracerebral haemorrhage (Review) Perry LA, Berge E, Bowditch J, Forfang E, Rønning OM, Hankey GJ, Villanueva E, Al-Shahi Salman R Perry LA, Berge E, Bowditch J, Forfang E, Rønning OM, Hankey GJ, Villanueva E, Al-Shahi Salman R. Antithrombotic treatment after stroke due to intracerebral haemorrhage. Cochrane Database of Systematic Reviews 2017, Issue 5. Art. No.: CD012144. DOI: 10.1002/14651858.CD012144.pub2. www.cochranelibrary.com Antithrombotic treatment after stroke due to intracerebral haemorrhage (Review) Copyright © 2017 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. TABLE OF CONTENTS HEADER....................................... 1 ABSTRACT ...................................... 1 PLAINLANGUAGESUMMARY . 2 SUMMARY OF FINDINGS FOR THE MAIN COMPARISON . ..... 3 BACKGROUND .................................... 5 OBJECTIVES ..................................... 5 METHODS ...................................... 6 RESULTS....................................... 8 Figure1. ..................................... 9 Figure2. ..................................... 11 Figure3. ..................................... 12 DISCUSSION ..................................... 14 AUTHORS’CONCLUSIONS . 15 ACKNOWLEDGEMENTS . 15 REFERENCES ..................................... 15 CHARACTERISTICSOFSTUDIES . 18 DATAANDANALYSES. 31 Analysis 1.2. Comparison 1 Short-term antithrombotic treatment, Outcome 2 Death. 31 Analysis 1.6. Comparison 1 Short-term antithrombotic
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 6,518,244 B2 Cardin Et Al
    USOO651824.4B2 (12) United States Patent (10) Patent No.: US 6,518,244 B2 Cardin et al. (45) Date of Patent: Feb. 11, 2003 (54) COMBINATIONS OF HEPARIN COFACTOR OTHER PUBLICATIONS II AGONIST AND PLATELET IIB/IIIA Nicolini et al. Chem. Abst. 121:170,096 (1994).* ANTAGONIST, AND USES THEREOF Pavao et al., “A Unique Dermatan Sulfate-Like Glycosami noglycan from Ascidian,” J. Biol. Chem., (Dec. 29, 1995) (75) Inventors: Alan D. Cardin, Cincinnati, OH (US); 270(52):31027-31036. Cornelius L. Van Gorp, Springboro, Pouplard et al., “Antibodies to Platelet Factor 4-Heparin OH (US) After Cardiopulmonary Bypass in Patients Anticoagulated with Unfractionated Heparin or a Low Molecular Weight (73) Assignee: IntimaX Corporation, Cincinnati, OH Heparin:clinical Implications for Heparin-Induced Throm (US) bocytopenia.” Circulation (1999) 99:2539-2536. Prandoni et al., “Dermatan Sulfate: a Safe Approach to Notice: Subject to any disclaimer, the term of this Prevention of Postoperative Deep Vein Thrombosis,” Br. J. patent is extended or adjusted under 35 Surg. (1992) 79(6):505–509. U.S.C. 154(b) by 57 days. Adgey, “Bleeding Complications with New Antithrombotics Used in Ischemic Heart Disease,” Haemostasis (1996) 26(5):237-246. Agnelli et al., “A Randomized Double-Blind, Placebo-Con (21) Appl. No.: 09/802,775 trolled Trial of Dermatan Sulphate for Prevention of Deep (22) Filed: Mar. 9, 2001 Vein Thrombosis in Hip Fracture.” Thromb. Haemostas. (1992) 67:203-208. (65) Prior Publication Data Agnelli, “New Antithrombins and Nonheparin Glycosami noglycans in Clinical Development,” Vessels (1995) 1:9-16. US 2001/0036932 A1 Nov. 1, 2001 Ali et al., “Diffuse Alveolar Hemorrhage Following Admin istration of Tirofiban or Abciximab: a Nemesis of Platelet Related U.S.
    [Show full text]
  • Antithrombotic Agents in the Management of Sepsis
    Antithrombotic Agents in the Management of Sepsis !"#$ Loyola University Medical Center, Maywood, Illinois-60153, USA ABSTRACT Sepsis, a systemic inflammatory syndrome, is a response to infection and when associated with mul- tiple organ dysfunction is termed, severe sepsis. It remains a leading cause of mortality in the critically ill. The response to the invading bacteria may be considered as a balance between proinflammatory and antiinflammatory reaction. While an inadequate proinflammatory reaction and a strong antiinflammatory response could lead to overwhelming infection and death of the patient, a strong and uncontrolled pro- inflammatory response, manifested by the release of proinflammatory mediators may lead to microvas- cular thrombosis and multiple organ failure. Endotoxin triggers sepsis by releasing various mediators inc- luding tumor necrosis factor-alpha and interleukin-1(IL-1). These cytokines activate the complement and coagulation systems, release adhesion molecules, prostaglandins, leukotrienes, reactive oxygen speci- es and nitric oxide (NO). Other mediators involved in the sepsis syndrome include IL-1, IL-6 and IL-8; arachidonic acid metabolites; platelet activating factor (PAF); histamine; bradykinin; angiotensin; comp- lement components and vasoactive intestinal peptide. These proinflammatory responses are counterac- ted by IL-10. Most of the trials targeting the different mediators of proinflammatory response have failed due a lack of correct definition of sepsis. Understanding the exact pathophysiology of the disease will enable better treatment options. Targeting the coagulation system with various anticoagulant agents inc- luding antithrombin, activated protein C (APC), tissue factor pathway inhibitor (TFPI) is a rational appro- ach. Many clinical trials have been conducted to evaluate these agents in severe sepsis.
    [Show full text]
  • Undergoing Elective Angioplasty in Patients with Stable Coronary Artery
    Downloaded from heart.bmjjournals.com on 17 October 2006 Pharmacodynamics and safety of lefradafiban, an oral platelet glycoprotein IIb/IIIa receptor antagonist, in patients with stable coronary artery disease undergoing elective angioplasty K M Akkerhuis, M J B M van den Brand, C van der Zwaan, H O J Peels, H Suryapranata, L R van der Wieken, J Stibbe, J Hoffmann, T Baardman, J W Deckers and M L Simoons Heart 2001;85;444-450 doi:10.1136/heart.85.4.444 Updated information and services can be found at: http://heart.bmjjournals.com/cgi/content/full/85/4/444 These include: References This article cites 27 articles, 17 of which can be accessed free at: http://heart.bmjjournals.com/cgi/content/full/85/4/444#BIBL 1 online articles that cite this article can be accessed at: http://heart.bmjjournals.com/cgi/content/full/85/4/444#otherarticles Rapid responses You can respond to this article at: http://heart.bmjjournals.com/cgi/eletter-submit/85/4/444 Email alerting Receive free email alerts when new articles cite this article - sign up in the box at the service top right corner of the article Topic collections Articles on similar topics can be found in the following collections Drugs: cardiovascular system (857 articles) Ischemic heart disease (2078 articles) Notes To order reprints of this article go to: http://www.bmjjournals.com/cgi/reprintform To subscribe to Heart go to: http://www.bmjjournals.com/subscriptions/ Downloaded from heart.bmjjournals.com on 17 October 2006 444 Heart 2001;85:444–450 Pharmacodynamics and safety of lefradafiban, an oral platelet glycoprotein IIb/IIIa receptor antagonist, in patients with stable coronary artery disease undergoing elective angioplasty K M Akkerhuis, MJBMvandenBrand, C van der Zwaan, HOJPeels, H Suryapranata, L R van der Wieken, J Stibbe, J HoVmann, T Baardman, J W Deckers, M L Simoons Abstract Objective—Lefradafiban is the orally active prodrug of fradafiban, a glycoprotein IIb/IIIa receptor antagonist.
    [Show full text]
  • Antiplatelet Therapy in Cardiovascular Disease M W H Behan, R F Storey
    155 Postgrad Med J: first published as 10.1136/pgmj.2003.007062 on 11 March 2004. Downloaded from CARDIOLOGY UPDATE Antiplatelet therapy in cardiovascular disease M W H Behan, R F Storey ............................................................................................................................... Postgrad Med J 2004;80:155–164. doi: 10.1136/pgmj.2003.007062 Platelet activation and aggregation are considered to be and collagen covered by a layer of connective tissue. Also present in the core are cholesterol- central to arterial thrombus formation. Antiplatelet therapy containing macrophages (foam cells), derived is therefore important for both the treatment and prevention from monocytes that have crossed the endothe- of cardiovascular disease. Aspirin, the most widely used lium from the arterial lumen. These cells produce large amounts of prothrombotic tissue factor antiplatelet agent, inhibits platelet cyclo-oxygenase and the together with several inflammatory cell media- conversion of arachidonic acid to the potent platelet tors such as tumour necrosis factor-a and various agonist thromboxane A but does not prevent platelet interleukins.3910 2 The process of thrombosis starts when the activation occurring via various signalling pathways that atherosclerotic plaque tears and exposes the are independent of thromboxane A2 release. Therefore a lipid-rich core to blood in the arterial lumen. number of other compounds have been developed to Platelet adherence to the exposed subendothe- lium and collagen results in platelet activation complement aspirin’s beneficial effect. These include the and the release and local accumulation of soluble thienopyridines (clopidogrel and ticlopidine), platelet agonists (thrombin, adenosine dipho- dipyridamole, and the a b (glycoprotein IIb/IIIa) receptor sphate (ADP), serotonin, and thromboxane A2). IIb 3 This in turn causes further platelet aggregation, inhibitors.
    [Show full text]
  • A Aaas. See Abdominal Aortic Aneurysms Aads. See Adjuvant
    Index A Acetylsalicylic acid (ASA) treatment, cost-effectiveness of, AAAs. See Abdominal aortic coronary artery spasm, 957 2773, 2775 aneurysms MI, 938 Acute myocardial infarction (AMI), 21. AADs. See Adjuvant antiarrhythmic non-STEMI, 957 See also Non-ST elevation drugs stable angina, 922 acute myocardial infarction; Abciximab, 946, 950, 954 unstable angina, 954, 957 ST elevation acute myocardial AMI, 1024 ACHEIVETM stent, 1037 infarction adjunctive treatment with, 1023 Acquired immunodeficiency syndrome aging and, 2446 CAD, unstable, 1010 (AIDS) anterior wall KD, 986 antiviral therapies for, metabolic V4R value and, 65 non-STEMI, 957, 958 complications of, 2378 occlusions and, 62–64 STEMI, 968 treatment for, 2380 bundle branch block in, 1993–1994, transfusion/blood conservation, 2509 cardiac involvement, prevalence of at 1995 unstable angina, 957 autopsy, 2371–2372 treatment of, 1994 Abdominal aortic aneurysms (AAAs), cardiomyopathy in, 2376–2377 clinical recognition 1644–1648 alternative explanations for, auscultation, 681–683 background and history, 1771 2378–2379 ECG diagnosis, 683 clinical recognition, 1645, 1646–1647 cytokines as possible cause of, inspection and palpation, 679–681 endovascular procedures for 2378 myocardial scintigraphy, 686–687 treatment of drug-induced, 2379 myocardial stunning and patient selection, 1773–1774 myocardial cell injury and, 2378 hibernation, 683 stent grafts, design characteristics cardiovascular involvement in, serum enzyme and cardiac of, 1771–1773 2371–2381 intracellular substance natural history, 1644 PHT and, 2380–2381 changes in, 683–686 surgical repair, 1645–1648 DCM and, 1241–1242 complications of, echocardiography Abdominal disorders, PTE and, 2188 echocardiography and prevalence of and, 815–819 Ablation. See also specific ablations cardiovascular abnormalities coronary heart disease and, 677–691 AF, 1973–1974 in, 2372–2374 differential diagnosis, 687 SND, 1937 health care workers and, 2381 echocardiographic assessment of, ABT-578, DES, 1034 heart neoplasms and, 2272 813–814 ACAD.
    [Show full text]
  • Stembook 2018.Pdf
    The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 WHO/EMP/RHT/TSN/2018.1 © World Health Organization 2018 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances. Geneva: World Health Organization; 2018 (WHO/EMP/RHT/TSN/2018.1). Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data.
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 9,314.499 B2 Wang Et Al
    USOO931.4499B2 (12) United States Patent (10) Patent No.: US 9,314.499 B2 Wang et al. (45) Date of Patent: Apr. 19, 2016 (54) ANNEXIN A2 AND TISSUE PLASMINOGEN Angelillo-Scherrer, et al., “Deficiency or Inhibition of Gas6 Causes ACTIVATOR FORTREATING VASCULAR Platelet Dysfunction and Protects Mice against Thrombosis.” Nat Med, 7(2):215-221 (2001). DISEASE Armstead, et al., Neutralizing the neurotoxic effects of exogenous and endogenous tA. Nat Neurosci. 9(9): 1150-1155 (2006). (71) Applicant: The General Hospital Corporation, Asahi, et al., “Reduction of Tissue Plasminogen Activator-Induced Boston, MA (US) Hemorrhage and Brain Injury by Free Radical Spin Trapping after Embolic Focal Cerebral Ischemia in Rats.' J Cereb Blood Flow Metab, 2003):452-457 (2000). (72) Inventors: Xiaoying Wang, West Roxbury, MA Benchenane, et al., “Equivocal Roles of Tissue-Type Plasminogen (US); Eng Lo, Newton, MA (US) Activator in Stroke-Induced Injury.” Trends Neurosci. 27(3): 155-160 (2004). (73) Assignee: The General Hospital Corporation, Benchenane, et al., “Tissue-Type Plasminogen Activator Crosses the Boston, MA (US) Intact Blood-Brain Barrier by Low-Density Lipoprotein Receptor Related Protein-Mediated Transcytosis.” Circulation, 111(17):2241 2249 (2005). (*) Notice: Subject to any disclaimer, the term of this Benz and Hofmann, “Annexins: From Structure to Function.” Biol patent is extended or adjusted under 35 Chem, 378(3-4): 177-183 (1997). U.S.C. 154(b) by 0 days. Brott, et al., “Urgent Therapy for Stroke. Part I. Pilot Study of Tissue Plasminogen Activator Administered within 90 Minutes.” Stroke, (21) Appl. No.: 14/197.988 23(5):632-640 (1992).
    [Show full text]
  • Reproductive Health Guideline Appendix 3 – Search Strategies
    SUPPLEMENTARY APPENDIX 3: Search Strategies 2020 American College of Rheumatology Guideline for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases All searches initially run on 11/8/2017 and updated on 5/8/2018. Searches run from database inception to 5/8/2018. PUBMED Syntax Guide for PubMed [MeSH] = Medical Subject Heading [Text Word] = Includes all words and numbers in the title, abstract, other abstract, MeSH terms, MeSH Subheadings, Publication Types, Substance Names, Personal Name as Subject, Corporate Author, Secondary Source, Comment/Correction Notes, and Other Terms - typically non-MeSH subject terms (keywords)…assigned by an organization other than NLM [MeSH subheading] = a Medical Subject [Title/Abstract] = Includes words in the title Heading subheading, e.g.
    [Show full text]
  • United States Patent (19) 11 Patent Number: 6,136,794 Cook Et Al
    USOO6136794A United States Patent (19) 11 Patent Number: 6,136,794 Cook et al. (45) Date of Patent: *Oct. 24, 2000 54) PLATELET AGGREGATION INHIBITION vol. 337, No. 7, pp. 447-452, (Aug. 14, 1997). USING LOW MOLECULAR WEIGHT Clive Kearon, “Low-Molecular-Weight Heparin versus HEPARIN IN COMBINATION WITH A GP Unfractionated Heparin for Unstable Coronary Disease”, IIB/IIIA ANTAGONIST The New England Journal of Medicine, vol. 338, No. 2, pp. 129-130 (Jan. 8, 1998). 75 Inventors: Jacquelynn J. Cook, Collegeville; Frederick et al., “The Protective Dose of the Potent GPIIb/ Robert J. Gould, Green Lane; IIIa Antagonist SC-54701 A. .”, Circulation, vol. 93, No. Frederic L. Sax, Villanova, all of Pa. 1, pp. 129-134 (Jan. 1, 1996). Angus, K., “Cryptosporidiosis and AIDS”, Bailliere's Clini 73 Assignee: Merck & Co., Inc., Rahway, N.J. cal Gastroenterology, vol. 4, No. 2, pp. 425-441 (Jun. 1990). * Notice: This patent issued on a continued pros Ashman, R. et al., “Production and Function of Cytokines in ecution application filed under 37 CFR Natural and Acquired Immunity to Candida albicans Infec 1.53(d), and is subject to the twenty year tion”, Microbiological Reviews, vol. 59. No. 4, pp. 646-672 patent term provisions of 35 U.S.C. (Dec. 1995). Derwent Abstract for ZA9209143, Sep. 29, 1993, Acc. No. 154(a)(2). 93-386927/199348. Barrios, C. et al., “Mycobacterial heat-Shock proteins as 21 Appl. No.: 09/240,429 carrier molecules. II: The use of the 70-kDa mycobacterial 22 Filed: Jan. 29, 1999 heat-Shock protein as carrier for conjugated vaccines can circumvent the need for adjuvants and Bacillus Calmette Related U.S.
    [Show full text]
  • Platelet Glycoprotein Iib/Iiia Antagonists Pharmacology and Clinical Developments Peter C
    Ⅵ REVIEW ARTICLE David C. Warltier, M.D., Ph.D., Editor Anesthesiology 2002; 96:1237–49 © 2002 American Society of Anesthesiologists, Inc. Lippincott Williams & Wilkins, Inc. Platelet Glycoprotein IIb/IIIa Antagonists Pharmacology and Clinical Developments Peter C. A. Kam, F.R.C.A., F.A.N.Z.C.A., F.C.A.R.C.S.I., F.H.K.C.A.(Hon.),* Mark K. Egan, F.A.N.Z.C.A.† Downloaded from http://pubs.asahq.org/anesthesiology/article-pdf/96/5/1237/404746/0000542-200205000-00029.pdf by guest on 01 October 2021 PLATELETS are critical for normal hemostasis and throm- with plasma coagulation factors causes a conformational bus formation.1 Thrombus formation initiated by plate- change in the glycoprotein IIb/IIIa receptor complex. lets plays a central role in the pathogenesis of acute Activated glycoprotein IIa/IIIb receptors become recep- coronary syndromes (unstable angina and myocardial tive to fibrinogen that, on binding to glycoprotein IIb/ infarction). Platelets are involved in events causing an- IIIa receptors located on two different platelets, builds gioplasty failure and stent thrombosis and may also play the cross-link for platelet-to-platelet aggregation.5 The an important role in restenosis through the release of initial thrombus contains a platelet-rich core (white potent prothrombotic, vasoactive, mitogenic, and in- thrombus) that may enlarge progressively from an in- flammatory factors.2,3 The identification of the platelet creasingly large fibrin net that entraps erythrocytes and glycoprotein IIb/IIIa receptor, a fibrinogen receptor im- leukocytes to form the “red” thrombus. Blood flow de- portant for platelet aggregation, has led to the develop- clines as the thrombus develops, and interactions be- ment of receptor antagonists.
    [Show full text]
  • Harmonized Tariff Schedule of the United States (2004) -- Supplement 1 Annotated for Statistical Reporting Purposes
    Harmonized Tariff Schedule of the United States (2004) -- Supplement 1 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2004) -- Supplement 1 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABACAVIR 136470-78-5 ACEXAMIC ACID 57-08-9 ABAFUNGIN 129639-79-8 ACICLOVIR 59277-89-3 ABAMECTIN 65195-55-3 ACIFRAN 72420-38-3 ABANOQUIL 90402-40-7 ACIPIMOX 51037-30-0 ABARELIX 183552-38-7 ACITAZANOLAST 114607-46-4 ABCIXIMAB 143653-53-6 ACITEMATE 101197-99-3 ABECARNIL 111841-85-1 ACITRETIN 55079-83-9 ABIRATERONE 154229-19-3 ACIVICIN 42228-92-2 ABITESARTAN 137882-98-5 ACLANTATE 39633-62-0 ABLUKAST 96566-25-5 ACLARUBICIN 57576-44-0 ABUNIDAZOLE 91017-58-2 ACLATONIUM NAPADISILATE 55077-30-0 ACADESINE 2627-69-2 ACODAZOLE 79152-85-5 ACAMPROSATE 77337-76-9 ACONIAZIDE 13410-86-1 ACAPRAZINE 55485-20-6 ACOXATRINE 748-44-7 ACARBOSE 56180-94-0 ACREOZAST 123548-56-1 ACEBROCHOL 514-50-1 ACRIDOREX 47487-22-9 ACEBURIC ACID 26976-72-7
    [Show full text]