Title (en) Haloperoxidase for the treatment of infection and control of flora

Title (de) Haloperoxidase zur Behandlung von Infektionen und Kontrolle der Flora

Title (fr) Haloperoxidase pour le traitement des infections et le contrôle de la flore

Publication EP 0923939 B1 20070620 (EN)

Application EP 98122809 A 19920221

Priority • EP 92301448 A 19920221 • US 66099491 A 19910221

Abstract (en) [origin: EP0500387A2] Haloperoxidases are used to selectively bind to and, in the presence of peroxide and halide, inhibit the growth of target microbes without eliminating desirable microbes or significantly damaging other components, such as host cells, in the environment of the target microbe. When a target microbe, e.g., a pathogenic microbe, has a binding capacity for haloperoxidase greater than that of a desired microbe, e.g., members of the normal flora, the target microbe selectively binds the haloperoxidase with little or no binding of the haloperoxidase by the desired microbe. In the presence of peroxide and halide, the target bound haloperoxidase catalyzes halide oxidation and facilitates the disproportionation of peroxide to singlet molecular oxygen at the surface of the target microbe. The lifetime of singlet molecular oxygen restricts damage to the surface resulting in selective killing of the target microbe with a minimum of collateral damage to the desired microbe or physiological medium. The methods and compositions of the invention are highly useful in the therapeutic or prophylactic antiseptic treatment of human or animal subjects, since their use can be designed to be highly effective in combatting bacterial or fungal infections without significant damage to normal flora or host cells. Suitable haloperoxidases include myeloperoxidase (MPO), eosinophil peroxidase (EPO), lactoperoxidase (LPO), chloroperoxidase (CPO) and derivatives thereof capable of selective binding to target microbes.

IPC 8 full level A61K 38/44 (2006.01); A01N 63/00 (2006.01); A61K 33/20 (2006.01); A61K 33/40 (2006.01); A61L 12/08 (2006.01); A61L 12/12 (2006.01); A61L 15/38 (2006.01); A61L 15/46 (2006.01); A61P 31/00 (2006.01); A61P 31/04 (2006.01); A61P 43/00 (2006.01); C12N 9/08 (2006.01)

CPC (source: EP KR US) A01N 63/50 (2020.01 - EP US); A61K 9/70 (2013.01 - KR); A61K 38/44 (2013.01 - EP KR US); A61L 12/082 (2013.01 - EP US); A61L 12/126 (2013.01 - EP US); A61L 15/38 (2013.01 - EP US); A61L 15/46 (2013.01 - EP US); A61P 31/00 (2018.01 - EP); A61P 31/04 (2018.01 - EP); A61P 43/00 (2018.01 - EP); A61L 2300/254 (2013.01 - EP US); A61L 2300/404 (2013.01 - EP US)

C-Set (source: EP US) 1. A61K 38/44 + A61K 38/44 + A61K 33/40 + A61K 33/40 + A61K 33/00 + A61K 33/00 2. A61K 38/44 + A61K 38/44 + A61K 2300/00 + A61K 2300/00 3. A01N 63/50 + A01N 63/50 + A01N 63/30 + A01N 63/30

Designated contracting state (EPC) AT BE CH DE DK ES FR GB GR IT LI LU MC NL PT SE

DOCDB simple family (publication) EP 0500387 A2 19920826; EP 0500387 A3 19921028; EP 0500387 B1 19990707; AT 181837 T 19990715; AT 365048 T 20070715; AU 1536492 A 19920915; AU 663869 B2 19951026; CA 2061601 A1 19920822; CA 2061601 C 20030408; DE 69229512 D1 19990812; DE 69229512 T2 20000330; DE 69233698 D1 20070802; DE 69233698 T2 20080228; EP 0923939 A1 19990623; EP 0923939 B1 20070620; IE 20000984 A1 20010530; IE 920514 A1 19920826; IL 100997 A 19960912; IL 100997 D0 19921115; JP 2004300157 A 20041028; JP 4063317 B2 20080319; JP H06505482 A 19940623; KR 930703012 A 19931129; US 6294168 B1 20010925; WO 9214484 A1 19920903

DOCDB simple family (application) EP 92301448 A 19920221; AT 92301448 T 19920221; AT 98122809 T 19920221; AU 1536492 A 19920214; CA 2061601 A 19920220; DE 69229512 T 19920221; DE 69233698 T 19920221; EP 98122809 A 19920221; IE 20000984 A 19920218; IE 920514 A 19920218; IL 10099792 A 19920218; JP 2004167857 A 20040604; JP 50731092 A 19920214; KR 930702510 A 19930821; US 27158394 A 19940707; US 9201237 W 19920214