Gestation-Based Viability–Difficult Decisions with Far-Reaching
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children Opinion Gestation-Based Viability–Difficult Decisions with Far-Reaching Consequences Sumesh Thomas 1,* and Elizabeth Asztalos 2 1 Department of Pediatrics, Section of Neonatology, University of Calgary, C536-1403 29St Nw, Calgary, AB T2N 2T9, Canada 2 Department of Newborn and Developmental Paediatrics, Sunnybrook Health Sciences Centre, University of Toronto, M4-230, 2075 Bayview Ave., Toronto, ON M4N 3M5, Canada; [email protected] * Correspondence: [email protected] Abstract: Most clinicians rely on outcome data based on completed weeks of gestational of fetal maturity for antenatal and postnatal counseling, especially for preterm infants born at the margins of viability. Contemporary estimation of gestational maturity, based on ultrasounds, relies on the use of first-trimester scans, which offer an accuracy of ±3–7 days, and depend on the timing of the scans and the measurements used in the calculations. Most published literature on the outcomes of babies born prematurely have reported on short- and long-term outcomes based on completed gestational weeks of fetal maturity at birth. These outcome data change significantly from one week to the next, especially around the margin of gestational viability. With a change in approach solely from decisions based on survival, to disability-free survival and long-term functional outcomes, the complexity of the parental and care provider’s decision-making in the perinatal and postnatal period for babies born at less than 25 weeks gestation remains challenging. While sustaining life following birth at the margins of viability remains our priority—identifying and mitigating risks associated with extremely preterm birth begins in the perinatal period. The challenge of supporting the normal Citation: Thomas, S.; Asztalos, E. maturation of these babies postnatally has far-reaching consequences and depends on our ability Gestation-Based Viability–Difficult to sustain life while optimizing growth, nutrition, and the repair of organs compromised by the Decisions with Far-Reaching consequences of preterm birth. This article aims to explore the ethical and medical complexities Consequences. Children 2021, 8, 593. of contemporary decision-making in the perinatal and postnatal periods. We identify gaps in our https://doi.org/10.3390/ current knowledge of this topic and suggest areas for future research, while offering a perspective for children8070593 future collaborative decision-making and care for babies born at the margins of viability. Academic Editor: Anneloes van Baar Keywords: viability; prematurity; gestational maturity; counseling Received: 19 June 2021 Accepted: 8 July 2021 Published: 13 July 2021 1. Historical Perspective Publisher’s Note: MDPI stays neutral Over the last 50 years, improvements in the survival and outcomes following preterm with regard to jurisdictional claims in birth have changed significantly. While improvements in obstetric care have contributed published maps and institutional affil- to improvements in premature infant survival, the incidence of preterm birth continues iations. to rise globally [1]. The incidence of live births at 22–25 weeks of gestation is reported at 4.7 per 1000 births in the USA (2014), 3.3 in Canada (2009–2014), 3.2 in the UK (2014–2015), 1.6 in Sweden (2011–2014), and 1.3 in Japan (2014–2015) [2]. In the 1960s, delivery before 28 weeks completed gestation was considered ‘previable’; Copyright: © 2021 by the authors. however, by the 1990s, about 50% of babies born at 24 weeks survived with neonatal Licensee MDPI, Basel, Switzerland. intensive care [3]. Over the last two decades, further improvements in survival and This article is an open access article functional outcomes of babies born at 24 weeks gestation has led to parents and care distributed under the terms and providers to offer active interventions for babies born at 23 and 22 weeks of gestational conditions of the Creative Commons maturity. Outcome reports from multicenter databases (i.e., from the USA, Eunice Kennedy Attribution (CC BY) license (https:// Shriver National Institute of Child Health and Human Development (NICHD) 2008–2011; creativecommons.org/licenses/by/ and the Neonatal Research Network of Japan (NRNJ) 2008–2012) show variations in 4.0/). Children 2021, 8, 593. https://doi.org/10.3390/children8070593 https://www.mdpi.com/journal/children Children 2021, 8, 593 2 of 10 Children 2021, 8, x FOR PEER REVIEW 2 of 10 babiesoutcome born for between babies born22 and between 24 weeks 22 gestation, and 24weeks with mortality gestation, rates with of 50–90%, mortality with rates birth of at50–90%, 22 weeks with gestation, birth at 22over weeks a simi gestation,lar time overframe a (Figure similar time1) [4–6]. frame (Figure1)[4–6]. 100% 11% 18% 90% 23% 28% 13% 34% 80% 15% 70% wk - completed weeks of gestation 19% 60% 32% 14% 17% Lost to follow up 50% 97% NDI - Neurodevelopmental Impairment 40% 26% 76% Absent NDI - Neurodevelopmental Impairment 30% 34% 54% Present 44% 20% Death 27% 10% 15% 0% 22 wk 23 wk 24 wk 22 wk 23 wk 24 wk (n (n= 234)= 234) (n = 450)450) (n(n = = 664)664) (n = 271)271) (n(n == 686) 686) (n(n == 883)883) USA (NICHD 2008-2011) Japan (NRNJ 2008-2012) Figure 1. Outcome reports from multicentermulticenter databases. A recent publication from Uppsala, Sweden, reports 50% survival of babies born at 22 weeks gestation with over 50% of survivors reported as unimpaired at 30 months of age, with a uniform approach of offering active perinatal and neonatalneonatal interventions for babies born beyond 22 weeks gestation betweenbetween 2006 and 2015 [[7].7]. A similar publication (over the same period) from Iowa, USA, offeringoffering a selective approach based on parental wishes, reportedreported 63%63% survivalsurvival at at 22 22 weeks weeks gestation gestation [8 ].[8]. These These two two sites sites offer offer a comparative a compara- tiveperspective perspective for outcome for outcome at the at margins the margins of viability, of viability, although although the number the number of infants of treatedinfants wastreated relatively was relatively small, the small, periods the periods were similar, were withsimilar, potentially with potentially fewer variations fewer variations in practice in practicethat influenced that influenced multisite multisite databases databases with similar with information similar information (Figure2 ).(Figure 2). The attitudes of care providers towards the outcomes of babies born at the margins of viability viability were were shown shown to to influence influence the the peri perinatalnatal care care of pregnancies of pregnancies at 22–24 at 22–24 weeks weeks ges- tationgestation and and subsequent subsequent neonatal neonatal outcomes outcomes [8–17]. [8–17 ].These These attitudes attitudes are are however however changing, changing, as outcome data from recent publications suggest survival and outcome data for babies born at 22 weeks gestation—similar to what was achieved in the early 1990s with babies born at 24 weeks gestation [18]. [18]. This gradual shift of approach in care will likely continue with promising data showing early disability-free survival beyond 22 weeks gestation. Recognition of this change in practice has led to the publication of consensus statements, regarding the approach to pregnancies andand birthsbirths atat thethe marginsmargins ofof viabilityviability [[19].19]. Children 2021, 8, 593 3 of 10 Children 2021, 8, x FOR PEER REVIEW 3 of 10 Study Period 2006 – 2015 180% 160% 140% 79% 120% 85% 68% 94% 90% 86% 100% 55% 80% 71% 80% 60% 89% 40% 82% 79% 63% 64% 70% 71% 52% 56% 20% 0% 22 weeks 23 weeks 24 weeks 22 weeks 23 weeks 24 weeks 22 weeks 23 weeks 24 weeks Iowa (Selective active approach) Uppsala (Active approach for all) Combined results Survived to discharge Mild disability/ Disability free survival FigureFigure 2.2. ComparativeComparative perspectiveperspective forfor outcomeoutcome atat thethe marginsmargins ofof viability.viability 2. Gestational Maturity The short-short- andand long-term long-term outcomes outcomes for for fetuses fetuses born born at theat the margins margins of viability of viability depend de- onpend multiple on multiple factors, factors, including including gestational gestational maturity, maturity, fetal weight,fetal weight, fetal wellbeing,fetal wellbeing, maternal ma- health,ternal health, fetal and fetal maternal and maternal co-morbidities, co-morbidities, available available resources, resources, social and social economic and economic consid- erations,considerations, societal societal expectations, expectations, ethical ethical and moral and considerations,moral considerations, values, values, and attitudes and atti- of caretudes providers of care providers and families. and Gestationalfamilies. Gestational maturity maturity however however remains theremains starting the point starting for decisionspoint for decisions related to related viability to forviability potential for birthspotential between births 22between and 24 22 weeks. and 24 weeks. The Canadian Pediatric Society and Nuffield Nuffield Council on Bioethics offer recommen- dations for for the the antenatal antenatal counseling counseling and and manage managementment of babies of babies born born before before 26 weeks 26 weeks ges- gestation.tation. These These recommendations recommendations are are based based on on completed completed weeks weeks of of gestation gestation of gestation maturity [[20,21].20,21]. More commonly, gestationalgestational maturity is expressedexpressed