DOCSLIB.ORG

Research Day 2021 Program

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Research Day 2021 Program Western Michigan University ScholarWorks at WMU Research Day WMU Homer Stryker M.D. School of Medicine 2021 Research Day 2021 Program Western Michigan University Homer Stryker M.D. School of Medicine Follow this and additional works at: https://scholarworks.wmich.edu/medicine_research_day Part of the Life Sciences Commons, and the Medicine and Health Sciences Commons WMU ScholarWorks Citation Homer Stryker M.D. School of Medicine, Western Michigan University, "Research Day 2021 Program" (2021). Research Day. 298. https://scholarworks.wmich.edu/medicine_research_day/298 This Abstract is brought to you for free and open access by the WMU Homer Stryker M.D. School of Medicine at ScholarWorks at WMU. It has been accepted for inclusion in Research Day by an authorized administrator of ScholarWorks at WMU. For more information, please contact [email protected]. th 38 Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day Wednesday, April 21, 2021 8:00 a.m. – 12:00 p.m. TABLE OF CONTENTS INTRODUCTION ........................................................................................................... 4 KEYNOTE SPEAKER.................................................................................................... 6 SCHEDULE ..................................................................................................................... 7 ORAL PRESENTATIONS ............................................................................................. 8 ORAL ABSTRACTS ..................................................................................................... 21 POSTER PRESENTATIONS ....................................................................................... 74 POSTER ABSTRACTS ................................................................................................ 89 The complete program including abstracts is available on the Western Michigan University Homer Stryker M.D. School of Medicine website: http://med.wmich.edu/node/287 2 CME CREDIT The CME Activity Code is available at the beginning and end of the presentation. In support of improving patient care, Western Michigan University Homer Stryker M.D. School of Medicine is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. Credit amount subject to change. IPCE Credit This activity was planned by and for the healthcare team, and learners will receive 3.5 Interprofessional Continuing Education (IPCE) credits for learning and change. Physicians Western Michigan University Homer Stryker M.D. School of Medicine designates this live activity for a maximum of 3.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Pharmacists & Pharmacy Technicians Western Michigan University Homer Stryker M.D. School of Medicine designates this activity for 3.5 contact hours for pharmacists and pharmacy technicians. Pharmacists and pharmacy technicians should claim only credit commensurate with the extent of their participation in the activity. DISCLOSURES Please contact Continuing Education for a listing of disclosure statements from today’s presenters. 3 INTRODUCTION RESEARCH, EDUCATION, AND SCHOLARSHIP The commitment and participation of Western Michigan University Homer Stryker M.D. School of Medicine (WMed), its faculty, and the Kalamazoo scientific community in “Research Day” continues on this day marking a 38th anniversary milestone. One-hundred forty-two abstracts were received and reviewed by a panel of 56 judges. One-hundred twenty from last year, combined with one-hundred forty-two abstracts been accepted for either oral or poster presentation. Such success is due, of course to a large number of talented and dedicated people. We wish to acknowledge the participation of a group of faculty and thank them for volunteering their time and expertise to review the submissions. Each abstract was assigned based upon area of expertise. The judges’ evaluations were critical in determining the oral presentations and poster presentations for this year’s event. In addition, it is my privilege to have worked with this year’s Research Day organizing committee. This committee worked diligently over an extended period of time to bring you an exceptional learning and networking opportunity. Members of this year’s committee were: Melinda Abernethy Loyall Harris Maureen Owens Adil Akkouch Nichol Holodick Courtney Puffer Laura Bauler Krishna Jain John Spitsbergen Steven Crooks Erik Larson Gregory Vanden Heuvel Maria Demma Cabral Liz Lorbeer Peter Vollbrecht Jack Dewey Amy Lorber We hope this year’s Research Day will inspire you to pursue your own research and to, as well, support the basic, medical and healthcare research of our Southwestern Michigan Community colleagues. Gregory Vanden Heuvel, PhD Chair 2021 Research Day 4 Thank you to the following WMed professionals who dedicated their time to participate as abstract scoring judges. Melinda Abernethy, MD Mariam Ischander, MD Sara Allison, PhD Krishna Jain, MD Syed Alam, MD Keith Kenter, MD Fritz Allhoff, PhD Wendy Lackey, PhD Hakima Bachimi-Aqel, MD Erik Larson, PhD Joanne Baker, DO Mark Loehrke, MD Robert Baker, MD Elizabeth Lorbeer, EdM Susan Bannon, MD Aimee Madsen, M4 Daniel Barnas, MD Joshua Mastenbrook, MD Laura Bauler, PhD Thomas Melgar, MD Timothy Bauler, PhD Tracey Mersfelder, MD Raymond Bayer, M2 Gitonga Munene, MD Craig Beam, PhD Maureen Owens Thomas Blok, MD Dilip Patel, MD Karen Bovid, MD Kirsten Porter-Stransky, PhD Theodore Brown, MD Courtney Puffer, MA Maria Demma Cabral, MD Kelly Quesnelle, PhD Joseph Callas, MD Mark Schauer, MD Sreenivasa Chandana, MD Neelkamal Soares, MD Steven Crooks, PhD John Spitsbergen, MD Jack Dewey, M2 Ruqiya Shama Tareen, MD Christian Ertl, MD Timothy Trichler, MD Casey Fealko, M2 Gregory Vanden Heuvel, PhD Rolbert Fischre, MD Timothy VanderKooy, MD Theotonius Gomes, DO Peter Vollbrecht, PhD Lisa Graves, MD Perry Westerman, MD Jeffrey Greene, PhD Vishal Gupta, MD David Hartman, MD Nichol odick, Holodick,PhD Nichol PhD Holodick, PhD 5 KEYNOTE SPEAKER Ann Van Heest, M.D. University of Minnesota Shriner’s Children’s Twin Cities Pediatric Orthopedic Hand Surgeon Director, Residency Program for Orthopedic Surgery Ann Van Heest, MD, is a pediatric orthopaedic hand surgeon at the University of Minnesota Department of Orthopaedics and Shriners Children's Twin Cities. She is board certified by the American Board of Orthopedic Surgery with subspecialty certification in surgery of the hand. She received an undergraduate degree from St. Olaf College in Northfield, Minnesota, and earned a medical degree from the University of Minnesota Medical School. Dr. Van Heest completed an internship in general surgery at Hennepin County Medical Center in Minneapolis, and a residency in orthopaedic surgery at the University of Minnesota Hospital. She also completed a Harvard Hand and Upper Extremity Fellowship at Brigham and Women’s and Children’s Hospital in Boston, Massachusetts. Dr. Van Heest is a member of the American Academy of Orthopaedic Surgeons, American Society for Surgery of the Hand and American Orthopaedic Association. Along with her services to Shriners Children's Twin Cities, Dr. Van Heest serves as a professor in the department of orthopaedic surgery at the University of Minnesota, School of Medicine. Credentials: • Medical Degree, University of Minnesota Medical School, Minneapolis, Minn. • Internship, Hennepin County Medical Center, Minneapolis, Minn., General Surgery • Residency, University of Minnesota Hospital, Minneapolis, Minn., Orthopaedic Surgery • Fellowship, Harvard hand and Upper Extremity, Brigham and Woman’s/Children’s Hospital, Boston, Mass. 6 SCHEDULE Wednesday, April 21, 2021 8:00 a.m. – 12:00 p.m. 8:30-9:30 am Basic Science Amuze Interactive! Basic Science 2 Amuze Interactive! Medical Education Amuze Interactive! Clinical Research 1 Amuze Interactive! Clinical Research 2 Amuze Interactive! Community and Public Health Amuze Interactive! 9:30-9:45 am BREAK 9:45-10:45 am Basic Science – Medical Engineering Amuze Interactive! Basic Clinical Science Amuze Interactive! Clinical Research 3 Amuze Interactive! Clinical Research 4 Amuze Interactive! Community and Public Health Amuze Interactive! Social and Behavioral Sciences Amuze Interactive! 10:45-11:00 am BREAK 11:00 am -12:00 pm KEYNOTE SPEAKER Amuze Interactive! 7 ORAL PRESENTATIONS 8 Basic Science 1 8:30-9:00 am ANATOMY OF THE NAVICULOCUNEIFORM JOINT George Borrelli, MD; Mossub Qatu , MD; Christopher Traynor , MD; Joseph Weistroffer , MD; James Jastifer, MD MODULATION OF HIPPOCAMPAL GABAERGIC NEUTOTRANSMISSION AND GEPHRYIN LEVELS BY DIHYDROMYRICENTIN IMPROVES ANXIETY Amy Shao, BS; Jing Liang, MD PhD WHEN LIFE GIVES YOU GLUCOSE: DIFFERENCES IN GLUCOSE UPTAKE AND UTILIZATION SUGGEST ALTERED ASTROCYTE FUNCTION IN OBESITY MODELS Keenan Boulnemour, BS; Kendall Smith, BA; Daniel Micheli, BS; Peter Vollbrecht, PhD 9 Basic Science 2 8:30-9:08 am IMMUNO-DETECTION OF G4 DNA STRUCTURES FORMED FROM PKD1 SEQUENCES IMPLICATES STRUCTURE FORMATION IN CYSTOGENESIS Aimee Madsen, BS; Amy Lorber, BS; Kemin Su, PhD; Gloria Alvarado, PhD; Erik Larson, PhD 3D BIOPRINTED BARRIER CONSTRUCT FOR BONE HEALING IN SYSTEMIC INFLAMMATORY CONDITIONS Zeena Qiryaqoz, BS; Adil Akkouch, PhD THE ROLE OF IGM IN SELECTION OF THE MURINE
Load more

Recommended publications
  • Educational Paper Ciliopathies
    Eur J Pediatr (2012) 171:1285–1300 DOI 10.1007/s00431-011-1553-z REVIEW Educational paper Ciliopathies Carsten Bergmann Received: 11 June 2011 /Accepted: 3 August 2011 /Published online: 7 September 2011 # The Author(s) 2011. This article is published with open access at Springerlink.com Abstract Cilia are antenna-like organelles found on the (NPHP) . Ivemark syndrome . Meckel syndrome (MKS) . surface of most cells. They transduce molecular signals Joubert syndrome (JBTS) . Bardet–Biedl syndrome (BBS) . and facilitate interactions between cells and their Alstrom syndrome . Short-rib polydactyly syndromes . environment. Ciliary dysfunction has been shown to Jeune syndrome (ATD) . Ellis-van Crefeld syndrome (EVC) . underlie a broad range of overlapping, clinically and Sensenbrenner syndrome . Primary ciliary dyskinesia genetically heterogeneous phenotypes, collectively (Kartagener syndrome) . von Hippel-Lindau (VHL) . termed ciliopathies. Literally, all organs can be affected. Tuberous sclerosis (TSC) . Oligogenic inheritance . Modifier. Frequent cilia-related manifestations are (poly)cystic Mutational load kidney disease, retinal degeneration, situs inversus, cardiac defects, polydactyly, other skeletal abnormalities, and defects of the central and peripheral nervous Introduction system, occurring either isolated or as part of syn- dromes. Characterization of ciliopathies and the decisive Defective cellular organelles such as mitochondria, perox- role of primary cilia in signal transduction and cell isomes, and lysosomes are well-known
    [Show full text]
  • ARPKD): Kidney-Related and Non-Kidney-Related Phenotypes
    Pediatr Nephrol (2014) 29:1915–1925 DOI 10.1007/s00467-013-2634-1 EDUCATIONAL REVIEW Clinical manifestations of autosomal recessive polycystic kidney disease (ARPKD): kidney-related and non-kidney-related phenotypes Rainer Büscher & Anja K. Büscher & Stefanie Weber & Julia Mohr & Bianca Hegen & Udo Vester & Peter F. Hoyer Received: 26 April 2013 /Revised: 5 September 2013 /Accepted: 6 September 2013 /Published online: 10 October 2013 # IPNA 2013 Abstract Autosomal recessive polycystic kidney disease disease. In this review we focus on common and uncommon (ARPKD), although less frequent than the dominant form, is kidney-related and non-kidney-related phenotypes. Clinical a common, inherited ciliopathy of childhood that is caused by management of ARPKD patients should include consideration mutations in the PKHD1-gene on chromosome 6. The charac- of potential problems related to these manifestations. teristic dilatation of the renal collecting ducts starts in utero and can present at any stage from infancy to adulthood. Renal Keywords ARPKD . Extrarenal manifestation . Children . insufficiency may already begin in utero and may lead to early Hepatic fibrosis . Portal hypertension . Caroli’ssyndrome abortion or oligohydramnios and lung hypoplasia in the new- born. However, there are also affected children who have no evidence of renal dysfunction in utero and who are born with Introduction normal renal function. Up to 30 % of patients die in the perinatal period, and those surviving the neonatal period reach Autosomal recessive polycystic kidney disease (ARPKD) be- end stage renal disease (ESRD) in infancy, early childhood or longs to the family of cilia-related disorders and is an important adolescence. In contrast, some affected patients have been inherited disease with distinct clinical features and genetics.
    [Show full text]
  • Targeted Exome Sequencing Provided Comprehensive Genetic Diagnosis of Congenital Anomalies of the Kidney and Urinary Tract
    Journal of Clinical Medicine Article Targeted Exome Sequencing Provided Comprehensive Genetic Diagnosis of Congenital Anomalies of the Kidney and Urinary Tract 1,2, 3,4, 3 1,5 Yo Han Ahn y, Chung Lee y, Nayoung K. D. Kim , Eujin Park , Hee Gyung Kang 1,2,6,* , Il-Soo Ha 1,2,6, Woong-Yang Park 3,4,7 and Hae Il Cheong 1,2,6 1 Department of Pediatrics, Seoul National University College of Medicine, Seoul 03080, Korea; [email protected] (Y.H.A.); [email protected] (E.P.); [email protected] (I.-S.H.); [email protected] (H.I.C.) 2 Department of Pediatrics, Seoul National University Children’s Hospital, Seoul 03080, Korea 3 Samsung Genome Institute, Samsung Medical Center, Seoul 06351, Korea; [email protected] (C.L.); [email protected] (N.K.D.K.); [email protected] (W.-Y.P.) 4 Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul 06351, Korea 5 Department of Pediatrics, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul 07441, Korea 6 Kidney Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul 03080, Korea 7 Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 16419, Korea * Correspondence: [email protected] These authors equally contributed to this article. y Received: 31 January 2020; Accepted: 8 March 2020; Published: 10 March 2020 Abstract: Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of chronic kidney disease in children.
    [Show full text]
  • Article Case Report Congenital Hepatic Fibrosis
    Article Case report Congenital hepatic fibrosis: case report and review of literature Brahim El Hasbaoui, Zainab Rifai, Salahiddine Saghir, Anas Ayad, Najat Lamalmi, Rachid Abilkassem, Aomar Agadr Corresponding author: Zainab Rifai, Department of Pediatrics, Children’s Hospital, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco. [email protected] Received: 19 Jan 2021 - Accepted: 03 Feb 2021 - Published: 18 Feb 2021 Keywords: Fibrosis, hyper-transaminasemia, cholestasis, ciliopathy, case report Copyright: Brahim El Hasbaoui et al. Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cite this article: Brahim El Hasbaoui et al. Congenital hepatic fibrosis: case report and review of literature. Pan African Medical Journal. 2021;38(188). 10.11604/pamj.2021.38.188.27941 Available online at: https://www.panafrican-med-journal.com//content/article/38/188/full Congenital hepatic fibrosis: case report and review &Corresponding author of literature Zainab Rifai, Department of Pediatrics, Children’s Hospital, Faculty of Medicine and Pharmacy, Brahim El Hasbaoui1, Zainab Rifai2,&, Salahiddine University Mohammed V, Rabat, Morocco Saghir1, Anas Ayad1, Najat Lamalmi3, Rachid 1 1 Abilkassem , Aomar Agadr 1Department of Pediatrics, Military Teaching Hospital Mohammed V, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco, 2Department of Pediatrics, Children’s Hospital, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco, 3Department of Histopathologic, Avicenne Hospital, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco Article characterized histologically by defective Abstract remodeling of the ductal plate (DPM).
    [Show full text]
  • Management of Choledochal Cysts
    REVIEW CURRENT OPINION Management of choledochal cysts Sean M. Ronnekleiv-Kelly, Kevin C. Soares, Aslam Ejaz, and Timothy M. Pawlik Purpose of review Historically, surgical treatment of choledochal cyst consisted of cyst enterostomy. However, incomplete cyst excision can result in recurrent symptoms and malignant transformation within the cyst remnant. 09/20/2020 on BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMi0hCywCX1AWnYQp/IlQrHD3pxNPODIEKBpIl4WIJuUC3wZcoMyoyOwWjpQO3AzJmNqjsWy7MP1HEA== by https://journals.lww.com/co-gastroenterology from Downloaded Downloaded Accordingly, management of choledochal cyst now includes complete cyst excision whenever possible. We provide a review detailing the up to date management of choledochal cysts. We describe choledochal from cyst-type specific surgical approaches, the impact of minimally invasive surgery in choledochal cyst https://journals.lww.com/co-gastroenterology therapy, and long-term sequelae of choledochal cyst management. Recent findings Treatment of choledochal cyst aims to avoid the numerous hepatic, pancreatic, or biliary complications that may occur. More recently, minimally invasive approaches are being used for the treatment of choledochal cyst with acceptable morbidity and mortality. Moreover, long-term follow up of choledochal cyst patients after resection has demonstrated that although the risk of biliary malignancy is significantly decreased after choledochal cyst resection, these patients may remain at a slightly increased risk of biliary malignancy by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMi0hCywCX1AWnYQp/IlQrHD3pxNPODIEKBpIl4WIJuUC3wZcoMyoyOwWjpQO3AzJmNqjsWy7MP1HEA==
    [Show full text]
  • Massachusetts Birth Defects 2002-2003
    Massachusetts Birth Defects 2002-2003 Massachusetts Birth Defects Monitoring Program Bureau of Family Health and Nutrition Massachusetts Department of Public Health January 2008 Massachusetts Birth Defects 2002-2003 Deval L. Patrick, Governor Timothy P. Murray, Lieutenant Governor JudyAnn Bigby, MD, Secretary, Executive Office of Health and Human Services John Auerbach, Commissioner, Massachusetts Department of Public Health Sally Fogerty, Director, Bureau of Family Health and Nutrition Marlene Anderka, Director, Massachusetts Center for Birth Defects Research and Prevention Linda Casey, Administrative Director, Massachusetts Center for Birth Defects Research and Prevention Cathleen Higgins, Birth Defects Surveillance Coordinator Massachusetts Department of Public Health 617-624-5510 January 2008 Acknowledgements This report was prepared by the staff of the Massachusetts Center for Birth Defects Research and Prevention (MCBDRP) including: Marlene Anderka, Linda Baptiste, Elizabeth Bingay, Joe Burgio, Linda Casey, Xiangmei Gu, Cathleen Higgins, Angela Lin, Rebecca Lovering, and Na Wang. Data in this report have been collected through the efforts of the field staff of the MCBDRP including: Roberta Aucoin, Dorothy Cichonski, Daniel Sexton, Marie-Noel Westgate and Susan Winship. We would like to acknowledge the following individuals for their time and commitment to supporting our efforts in improving the MCBDRP. Lewis Holmes, MD, Massachusetts General Hospital Carol Louik, ScD, Slone Epidemiology Center, Boston University Allen Mitchell,
    [Show full text]
  • Curriculum Outline General Surgery
    CURRICULUM OUTLINE FOR GENERAL SURGERY 2018–2019 Surgical Council on Resident Education 1617 John F. Kennedy Boulevard Suite 860 Philadelphia, PA 19103 1-877-825-9106 [email protected] www.surgicalcore.org SCORE Curriculum Outline for General Surgery The SCORE® Curriculum Outline for General Surgery is a list of topics to be covered in a five- year general surgery residency program. The outline is updated annually to remain contempo- rary and reflect feedback from SCORE member organizations and specialty surgical societies. Topics are listed for all six competencies of the Accreditation Council for Graduate Medical Education (ACGME): patient care; medical knowledge; professionalism; interpersonal and communication skills; practice-based learning and improvement; and systems-based practice. The patient care topics cover 27 organ system- based categories, with each category separated into Diseases/Conditions and Operations/ Procedures. Topics within these two areas are then designated as Core or Advanced. Changes from the previous edition are indi- cated in the Excel version of this outline, avail- able at www.surgicalcore.org. Note that topics listed in this booklet may not directly match those currently on the SCORE Portal — this outline is forward-looking, reflecting the latest updates. The Surgical Council on Resident Education (SCORE) is a nonprofit consortium formed in 2006 by the principal organizations involved in U.S. surgical education. SCORE’s mission is to improve the education of general surgery residents through the development of a national curriculum for general surgery residency training. The members of SCORE are: American Board of Surgery American College of Surgeons American Surgical Association Association of Program Directors in Surgery Association for Surgical Education Review Committee for Surgery of the ACGME Society of American Gastrointestinal and Endoscopic Surgeons PATIENT CARE CONTENTS Page BY CATEGORY ............................................
    [Show full text]
  • SCORE Curriculum Outline for General Surgery
    Curriculum Outline for General Surgery 2015 – 2016 SURGICAL COUNCIL ON RESIDENT EDUCATION www.surgicalcore.org CURRICULUM OUTLINE FOR GENERAL SURGERY 2015–2016 Surgical Council on Resident Education 1617 John F. Kennedy Boulevard Suite 860 Philadelphia, PA 19103-1847 1-877-825-9106 [email protected] www.surgicalcore.org The SCORE® Curriculum Outline for General Surgery is a list of topics to be covered in a five- year general surgery residency program. The out- line is updated annually to remain contemporary and reflect feedback from SCORE member orga- nizations and specialty surgical societies. Topics are currently listed for four of the six competencies of the Accreditation Council for Graduate Medical Education (ACGME): patient care; medical knowledge; interpersonal and communication skills; and systems-based practice. The patient care topics cover 28 organ system-based categories, with each category separated into Diseases/Conditions and Operations/Procedures. As of this edition, topics within these two areas are then designated as Core (formerly Broad or Essential) or Advanced (formerly Focused or Complex). Additional changes from the previous edition are indicated in the Excel version of this outline, available at www.surgicalcore.org. Please note topics listed in this booklet may not directly match those currently on the SCORE Portal — this booklet is forward-looking, reflecting the latest updates. The Surgical Council on Resident Education (SCORE) is a nonprofit consortium formed in 2006 by the principal organizations involved in U.S. surgical education. SCORE’s mission is to improve the education of general surgery residents through the development of a national curriculum for general surgery residency training.
    [Show full text]
  • Total Versus Conventional Laparoscopic Cyst
    Liu et al. BMC Surg (2020) 20:243 https://doi.org/10.1186/s12893-020-00906-5 RESEARCH ARTICLE Open Access Total versus conventional laparoscopic cyst excision and Roux-en-Y hepaticojejunostomy in children with choledochal cysts: a case– control study Fei Liu, Xiaogang Xu, Menglong Lan, Boyuan Tao, Le Li, Qiang Wu, Chengwei Chai and Jixiao Zeng* Abstract Background: To compare the efcacy of total and conventional laparoscopic hepaticojejunostomy (TLH and CLH) in children with choledochal cysts (CDCs). Methods: Data from patients undergoing TLH and CLH between August 2017 and December 2018 were retrospec- tively analyzed. Intraoperative blood loss, time for jejunum-cojejunum anastomosis, time to oral intake, postoperative hospital stay, hospitalization expenses, and postoperative complications were compared. Results: All 55 patients (TLH 30, CLH 25) were successfully treated without conversion to open surgery. In the TLH and CLH groups, the time= to oral intake= was 3.57 0.19 d and 4.56 0.27 d, respectively (t 3.07, P < 0.01), the postoperative hospital stay was 5.50 0.28 d and 7.00± 0.74 d (t 2.03,± P < 0.05), and the hospitalization= expenses were CNY 40,085 2447 and CNY 26,084± 2776 (t 3.79,± P < 0.001).= There were no signifcant diferences in intra- operative blood loss± (9.57 3.28 ml vs 8.2± 1.13 ml,= t 0.37, P 0.72) or time for jejunum-cojejunum anastomosis (80.5 2.46 min vs 75.00 ± 2.04 min, t 1.68,± P 0.10).= The median= follow-up periods of the TLH and CLH groups were 17 and± 16 months, respectively.± Overall= complication= rates were comparable between the two groups (10% vs 8%, χ2 0.07, P 0.79).
    [Show full text]
  • Congenital Hepatic Fibrosis with Polycystic Kidney Disease: an Unusual Cause of Neonatal Cholestasis
    CLINICOPATHOLOGICAL CONFERENCE Congenital Hepatic Fibrosis with Polycystic Kidney Disease: An Unusual Cause of Neonatal Cholestasis VANI BHARANI, *G VYBHAV VENKATESH, #UMA NAHAR SAIKIA AND $BR THAPA From Departments of Pathology,*Pediatrics, #Histopathology and $Gastroenterology, PGIMER, Chandigarh, Punjab, India. Correspondence to: Dr Uma Nahar Saikia, Department of Histopathology, 5th floor, Research Block A, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, India. [email protected] Received: June 23, 2016; Initial Review: October 13, 2016; Accepted: April 25, 2017. Congenital hepatic fibrosis is characterized by hepatic fibrosis, portal hypertension, and renal cystic disease. Typical presentation of congenital hepatic fibrosis is in the form of portal hypertension, in adolescents and young adults. We present an unusual case of neonatal cholestasis with rapid deterioration within first 4 months of life, who was diagnosed to have congenital hepatic fibrosis with polycystic kidney disease on autopsy. Keywords: Autopsy; Cholestatic Jaundice; Neonate. CLINICAL PROTOCOL 774 U/L, ALT 284 U/L). Persistent hyponatremia was recorded (115 meq/L). Random blood sugar was low at History and examination: A 4-month-old child was 48 mg/dL. admitted with complaints of jaundice since day 10 of life, passage of clay colored stool and dark colored urine. He No focus of infection could be identified and had intermittent high grade fever with dry cough and peritoneal fluid, urine and blood cultures were sterile. respiratory distress for 4 days duration. In addition, there Ultrasonogram (USG) of abdomen showed altered liver was progressive abdominal distension, decreased urine echo texture with gross ascites. Gall bladder was mildly output, irritability, poor feeding and lethargy since 2 days.
    [Show full text]
  • Department of Pathology & Laboratory Medicine
    F DEPARTMENT OF PATHOLOGY & LABORATORY MEDICINE Residency Procedure Manual Katie Dennis, MD, Residency Program Director Garth Fraga, MD and Sharad Mathur, MD, Associate Residency Program Directors Kim Ates, M.Ed., Residency/Fellowship Program Coordinator Revised October 2016 http://www.acgme.org/Portals/0/PFAssets/ProgramRequirements/300_pathology_2016.pdf 1 KUMC Pathology Residency Manual http://www.kumc.edu/Documents/gme/Web%20Ready%20Version%205.4%20%2012.2015.pdf 2 KUMC Pathology Residency Manual Table of Contents MISSION, GOALS AND PHILOSOPHY .....................................................................................................................5 RESIDENCY EDUCATIONAL PROGRAM .................................................................................................................6 PROGRAM STRUCTURE ........................................................................................................................................ 12 PGY-SPECIFIC GOALS ........................................................................................................................................... 14 GENERAL RESIDENCY GOALS ............................................................................................................................. 20 PRACTICE-BASED LEARNING AND IMPROVEMENT (PBLI) ............................................................................... 22 DIDACTIC SESSIONS AND CONFERENCES ........................................................................................................
    [Show full text]
  • Cystic Disease of the Liver and Biliary Tract Gut: First Published As 10.1136/Gut.32.Suppl.S116 on 1 September 1991
    S116 GutSupplement, 1991, S116-S122 Cystic disease of the liver and biliary tract Gut: first published as 10.1136/gut.32.Suppl.S116 on 1 September 1991. Downloaded from A Forbes, I M Murray-Lyon Abstract ances, aspiration for microbiological and cyto- The widespread availability of ultrasound logical examination is warranted. Several reports imaging has led to more frequent recognition - (for example,5 and our own unpublished obser- of cystic disease affecting the liver and biliary vations) of needle diagnosis of unsuspected hy- tract. There is a wide range ofpossible causes. datid disease, and even therapy by ultrasound Cystic disease of infective origin is usually guided transcutaneous injection of sclerosant,67 caused by an Echinococcal species, or as the indicate that ifthe transhepatic route is taken the sequel of a treated amoebic or pyogenic risk ofmorbidity is low. abscess. The clinical and radiological features Distinction of abscess from cyst is relatively are often then distinctive and will not be dwelt simple if an abscess has viscous echo dense upon in this review, except in respect of their contents with a thick wall and densely com- contribution to the differential diagnosis of pressed surrounding hepatic parenchyma. Per- non-infective disorders. The principal non- cutaneous aspiration allows confirmation of the infective cysts can be conveniently divided diagnosis, provides material for microbiological between the simple cyst, the polycystic syn- examination, and may be of major therapeutic dromes (usually with coexistent renal disease), benefit. Positive blood cultures or amoebic Caroli's syndrome, and choledochal cysts. serology may, however, render aspiration super- The overlap between constituent members of fluous, given that small single abscesses can be these groups, and the association of cystic effectively managed with systemic antimicro- disease with hepatic fibrosis (especially with bials alone.
    [Show full text]