SCORE Curriculum Outline for General Surgery
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Educational Paper Ciliopathies
Eur J Pediatr (2012) 171:1285–1300 DOI 10.1007/s00431-011-1553-z REVIEW Educational paper Ciliopathies Carsten Bergmann Received: 11 June 2011 /Accepted: 3 August 2011 /Published online: 7 September 2011 # The Author(s) 2011. This article is published with open access at Springerlink.com Abstract Cilia are antenna-like organelles found on the (NPHP) . Ivemark syndrome . Meckel syndrome (MKS) . surface of most cells. They transduce molecular signals Joubert syndrome (JBTS) . Bardet–Biedl syndrome (BBS) . and facilitate interactions between cells and their Alstrom syndrome . Short-rib polydactyly syndromes . environment. Ciliary dysfunction has been shown to Jeune syndrome (ATD) . Ellis-van Crefeld syndrome (EVC) . underlie a broad range of overlapping, clinically and Sensenbrenner syndrome . Primary ciliary dyskinesia genetically heterogeneous phenotypes, collectively (Kartagener syndrome) . von Hippel-Lindau (VHL) . termed ciliopathies. Literally, all organs can be affected. Tuberous sclerosis (TSC) . Oligogenic inheritance . Modifier. Frequent cilia-related manifestations are (poly)cystic Mutational load kidney disease, retinal degeneration, situs inversus, cardiac defects, polydactyly, other skeletal abnormalities, and defects of the central and peripheral nervous Introduction system, occurring either isolated or as part of syn- dromes. Characterization of ciliopathies and the decisive Defective cellular organelles such as mitochondria, perox- role of primary cilia in signal transduction and cell isomes, and lysosomes are well-known -
Breast Cysts
Beaumont Hospital Patient Information on Breast Cysts PRINTROOM PDF 23012017 SUP190B What are breast cysts? The breasts are made up of lobules (milk- producing glands) and ducts (tubes that carry milk to the nipple), surrounded by fatty and supportive tissue. Sometimes fluid-filled sacs develop in the breast tissue. These are breast cysts. It’s thought that they develop naturally as the breast ages and changes. Although you can develop breast cysts at any age, they are most common in women over 35 who haven’t yet reached menopause. They occur more frequently as women approach the menopause and usually resolve or are less frequent after it. However, they may persist or develop in women who take hormone replacement therapy (HRT) after menopause. Cysts can feel soft if they are near the surface of the skin, or like a hard lump if they’re deeper in the breast tissue. They can develop anywhere in the breast, but are more commonly found in the upper half. For some women cysts can feel uncomfortable or even painful. Before a period cysts may become larger, and feel sore and tender. It’s common to develop one or more cysts either in one breast or both breasts –and this is nothing to worry about. It is also common to have many cysts without knowing about them. How are they found? Cysts usually become noticeable as a lump in the breast, or are sometimes found by chance when you have a breast examination or routine mammography. When you have a breast examination your GP will sometimes be able to say whether the lump feels like a cyst. -
Skin Care, Insect Bites and Stings
DEPARTMENT KLINISCHE WETENSCHAPPEN | MEDISCHE DIENSTEN Kronenburgstraat 43/3, 2000 Antwerpen | Fax: +32 3 247 64 10 Updated version (20/05/2015 – AVG) see: www.travelhealth.be SKIN CARE, INSECT BITES AND STINGS Sun The closer you get to the Equator, the more intense sunlight becomes. Sunbathing in the tropics has to be done in moderation. Protective clothing and hats are recommended. Apply sun cream with high sun protection factor (30 or more) to exposed skin regularly (every two hours) and carefully. Apply sun cream after bathing and avoid long water exposure since sun stroke will be imminent in spite of reduced heat feeling. Avoid perfumed sun creams and check whether or not used creams or medication can cause "sun allergy" (photo-toxic or photo-allergic reactions). We would like to refer to point 5 of the European cancer code: avoid excessive exposure to sun and sunburn during childhood (increased risk of melanomas in later life). Do not take a course of sunbed sessions before going on holiday as the sun tan obtained through UV-A does not give any extra protection against the natural UV-rays. When using sun creams and insect repellents based on DEET, recent studies have shown that DEET reduces the effectiveness of the sun cream, but that sun creams do not have a negative influence on the effectiveness of DEET. It is advisable, therefore, to apply the insect repellent (DEET or another repellent) with the sun lotion and then to take additional precautions to protect against UV (e.g. a sun cream with a higher protection factor). -
Allergic Reactions to Bites and Stings
Allergic Reactions to Bites and Stings ASCIA EDUCATION RESOURCES (AER) PATIENT INFORMATION Most insect bites and stings result in a localised itch and swelling that settles within a few days. Severe allergic reactions (anaphylaxis) to insects are relatively uncommon, and are usually due to bees, wasps or the Australian Jack Jumper ant. Fortunately, effective treatments are available to treat allergic reactions to bites and stings. Stinging insects are a common cause of anaphylaxis Allergies to venoms from stinging insects are one of the most common causes of severe allergic reactions (anaphylaxis) in Australia. Symptoms include an all over rash, swelling of tongue or throat, trouble breathing, gut cramps, diarrhoea, vomiting or even a drop in blood pressure (shock). Although the insects are all hymenoptera (which means membranous winged insects), their venoms are very different. Allergy to one type of stinging insect does not usually increase the risk of reaction to another. The Honey Bee is the most common cause of allergic reactions in Australia. Paper Wasps and European Wasps can sting multiple times. The European Wasp is becoming an increasing problem in Australia, is particularly aggressive and likes to get inside drink cans at barbeques, although the more familiar Paper Wasp is responsible for the majority of serious stings. The Australian Jack Jumper Ant (Myrmecia pilosula) is a medium sized black bull ant prevalent down the eastern side of Australia and Tasmania. It can be recognised by its characteristic hopping motion when it walks. It is a very aggressive ant and its sting can cause severe local pain. Severe allergic reactions are much more common than is seen with more common bull ants. -
Approach to Breast Mass
APPROACH TO BREAST MASS Resident Author: Kathleen Doukas, MD, CCFP Faculty Advisor: Thea Weisdorf, MD, CCFP Creation Date: January 2010, Last updated: August 2013 Overview In primary care, breast lumps are a common complaint among women. In one study, 16% of women age 40-69y presented to their physician with a breast lesion over a 10-year period.1 Approximately 90% of these lesions will be benign, with fibroadenomas and cysts being the most common.2 Breast cancer must be ruled out, as one in ten woman who present with a new lump will have cancer.1 Diagnostic Considerations6 Benign: • Fibroadenoma: most common breast mass; a smooth, round, rubbery mobile mass, which is often found in young women; identifiable on US and mammogram • Breast cyst: mobile, often tender masses, which can fluctuate with the menstrual cycle; most common in premenopausal women; presence in a postmenopausal woman should raise suspicion for malignancy; ultrasound is the best method for differentiating between a cystic vs solid structure; a complex cyst is one with septations or solid components, and requires biopsy • Less common causes: Fat necrosis, intraductal papilloma, phyllodes tumor, breast abscess Premalignant: • Atypical Ductal Hyperplasia, Atypical Lobular Hyperplasia: Premalignant breast lesions with 4-6 times relative risk of developing subsequent breast cancer;8 often found incidentally on biopsy and require full excision • Carcinoma in Situ: o Ductal Carcinoma in Situ (DCIS): ~85% of in-situ breast cancers; defined as cancer confined to the duct that -
Tolvaptan in Autosomal Dominant Polycystic Kidney Disease: Three Years’ Experience
Article Tolvaptan in Autosomal Dominant Polycystic Kidney Disease: Three Years’ Experience Eiji Higashihara,*† Vicente E. Torres,*‡ Arlene B. Chapman,§ Jared J. Grantham, Kyongtae Bae,¶ Terry J. Watnick,** †† † ‡‡ ‡‡ ‡‡ 2 Shigeo Horie, Kikuo Nutahara, John Ouyang, Holly B. Krasa, Frank S. Czerwiec, for the TEMPO4 and 156-05-002 Study Investigators Summary †Kyorin University Background and objectives Autosomal dominant polycystic kidney disease (ADPKD), a frequent cause of School of Medicine, end-stage renal disease, has no cure. V2-specific vasopressin receptor antagonists delay disease progression Mitaka, Tokyo, Japan; ‡ in animal models. Mayo Clinic College of Medicine, Rochester, Minnesota; §Emory Design, setting, participants, and measurements This is a prospectively designed analysis of annual total kid- University School of ney volume (TKV) and thrice annual estimated GFR (eGFR) measurements, from two 3-year studies of Medicine, Atlanta, ʈ tolvaptan in 63 ADPKD subjects randomly matched 1:2 to historical controls by gender, hypertension, age, Georgia; Kansas and baseline TKV or eGFR. Prespecified end points were group differences in log-TKV (primary) and eGFR University Medical Center, Kansas City, (secondary) slopes for month 36 completers, using linear mixed model (LMM) analysis. Sensitivity analyses Kansas; ¶University of of primary and secondary end points included LMM using all subject data and mixed model repeated mea- Pittsburgh School of sures (MMRM) of change from baseline at each year. Pearson correlation tested the association between Medicine, Pittsburgh, log-TKV and eGFR changes. Pennsylvania; **Johns Hopkins University, Baltimore, Maryland; Results Fifty-one subjects (81%) completed 3 years of tolvaptan therapy; all experienced adverse events ††Teikyo University (AEs), with AEs accounting for six of 12 withdrawals. -
Avoiding and Treating Work-Related Insect Bites and Stings
FACT SHEET Avoiding and Treating Work-Related Insect Bites and Stings This WorkCare Fact Sheet describes work-related bite and sting risks, symptoms, treatment and preventive measures. Bites and stings are a relatively common occurrence for people who work outdoors and in enclosed environments where bees and wasps, fire ants, insects and arachnids (spiders, scorpions, ticks and mites) feel at home. Employers and workers are encouraged to understand exposure risks, how to recognize and respond to stings and bites, and what they can do to prevent them. Under 29 CFR Part 1904 – Recording and Reporting Occupational Injuries and Illnesses, the Occupational Safety and Health Administration (OSHA) considers bites and stings to be recordable when an employee who is bitten or stung while working receives medical treatment beyond first aid. First aid is defined in1904.7 (b)(5)(ii). Exposure Risk Thousands of people in the U.S. are stung or bitten each year. Exposed arms and hands tend to be more susceptible to stings and bites among workers than legs and feet, which are usually protected by clothing and enclosed shoes. In a study of occupationally related bites and stings, the head, one of the most exposed body parts, accounted for one-tenth of cases involving insects and arachnids; a third of those cases affected the eyes. An estimated 90 to 100 people die each year in the U.S. as a result of allergic reactions to bites and stings. Overall, bite- and sting-related injuries and fatalities may be misdiagnosed as heart attack or sunstroke, or attributed to other causes, according to the National Institute for Occupational Safety and Health (NIOSH). -
Research Day 2021 Program
Western Michigan University ScholarWorks at WMU Research Day WMU Homer Stryker M.D. School of Medicine 2021 Research Day 2021 Program Western Michigan University Homer Stryker M.D. School of Medicine Follow this and additional works at: https://scholarworks.wmich.edu/medicine_research_day Part of the Life Sciences Commons, and the Medicine and Health Sciences Commons WMU ScholarWorks Citation Homer Stryker M.D. School of Medicine, Western Michigan University, "Research Day 2021 Program" (2021). Research Day. 298. https://scholarworks.wmich.edu/medicine_research_day/298 This Abstract is brought to you for free and open access by the WMU Homer Stryker M.D. School of Medicine at ScholarWorks at WMU. It has been accepted for inclusion in Research Day by an authorized administrator of ScholarWorks at WMU. For more information, please contact [email protected]. th 38 Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day Wednesday, April 21, 2021 8:00 a.m. – 12:00 p.m. TABLE OF CONTENTS INTRODUCTION ........................................................................................................... 4 KEYNOTE SPEAKER.................................................................................................... 6 SCHEDULE ..................................................................................................................... 7 ORAL PRESENTATIONS ............................................................................................. 8 ORAL ABSTRACTS .................................................................................................... -
Unit 3 Bites and Stings
First Aid in Common and Environmental Emergencies UNIT 3 BITES AND STINGS Structure 3.0 Introduction 3.1 Objectives 3.2 Bites and Stings 3.2.1 Definition, Causes, Types and Recognition of Bites and Stings 3.2.2 Assessment of the Victim and General First Aid 3.3 Various Bites/Stings 3.3.1 Scorpion Bite and Spider Bite 3.3.2 Snake Bite 3.3.3 Insect Bite 3.3.4 Animal Bites (Dog Bite/Monkey Bites) 3.3.5 Human Bites 3.4 Let Us Sum Up 3.5 Keywords 3.6 Answers to Check Your Progress 3.7 References and Further Readings 3.0 INTRODUCTION Bites and stings are commonly seen in the rural and remote areas. Nowadays, however, they can occur in urban areas also. Lakhs of people every year are bitten or stung by someone or something. These emergencies include bites and stings due to various reasons. These bites or stings need to be identified and treated early as they affect some part or the whole of the body which can cause mild, moderate or severe reaction and can even be life-threatening. Most are not medical emergencies but however, treatment is usually required if there is bleeding, wounds or infection. All bites and stings are not same. Different First Aid treatment and care is needed depending on the type of insect or animal that has caused the bite. Some species are more dangerous and cause more harm compared to others. Hence, in this unit we shall discuss the different types of bites and stings, causes, recognition and first aid in these situations. -
ARPKD): Kidney-Related and Non-Kidney-Related Phenotypes
Pediatr Nephrol (2014) 29:1915–1925 DOI 10.1007/s00467-013-2634-1 EDUCATIONAL REVIEW Clinical manifestations of autosomal recessive polycystic kidney disease (ARPKD): kidney-related and non-kidney-related phenotypes Rainer Büscher & Anja K. Büscher & Stefanie Weber & Julia Mohr & Bianca Hegen & Udo Vester & Peter F. Hoyer Received: 26 April 2013 /Revised: 5 September 2013 /Accepted: 6 September 2013 /Published online: 10 October 2013 # IPNA 2013 Abstract Autosomal recessive polycystic kidney disease disease. In this review we focus on common and uncommon (ARPKD), although less frequent than the dominant form, is kidney-related and non-kidney-related phenotypes. Clinical a common, inherited ciliopathy of childhood that is caused by management of ARPKD patients should include consideration mutations in the PKHD1-gene on chromosome 6. The charac- of potential problems related to these manifestations. teristic dilatation of the renal collecting ducts starts in utero and can present at any stage from infancy to adulthood. Renal Keywords ARPKD . Extrarenal manifestation . Children . insufficiency may already begin in utero and may lead to early Hepatic fibrosis . Portal hypertension . Caroli’ssyndrome abortion or oligohydramnios and lung hypoplasia in the new- born. However, there are also affected children who have no evidence of renal dysfunction in utero and who are born with Introduction normal renal function. Up to 30 % of patients die in the perinatal period, and those surviving the neonatal period reach Autosomal recessive polycystic kidney disease (ARPKD) be- end stage renal disease (ESRD) in infancy, early childhood or longs to the family of cilia-related disorders and is an important adolescence. In contrast, some affected patients have been inherited disease with distinct clinical features and genetics. -
Index to the NLM Classification 2011
National Library of Medicine Classification 2011 Index Disease see Tyrosinemias 1-8 5,12-diHETE see Leukotriene B4 1,2-Benzopyrones see Coumarins 5,12-HETE see Leukotriene B4 1,2-Dibromoethane see Ethylene Dibromide 5-HT see Serotonin 1,8-Dihydroxy-9-anthrone see Anthralin 5-HT Antagonists see Serotonin Antagonists 1-Oxacephalosporin see Moxalactam 5-Hydroxytryptamine see Serotonin 1-Propanol 5-Hydroxytryptamine Antagonists see Serotonin Organic chemistry QD 305.A4 Antagonists Pharmacology QV 82 6-Mercaptopurine QV 269 1-Sar-8-Ala Angiotensin II see Saralasin 7S RNA see RNA, Small Nuclear 1-Sarcosine-8-Alanine Angiotensin II see Saralasin 8-Hydroxyquinoline see Oxyquinoline 13-cis-Retinoic Acid see Isotretinoin 8-Methoxypsoralen see Methoxsalen 15th Century History see History, 15th Century 8-Quinolinol see Oxyquinoline 16th Century History see History, 16th Century 17 beta-Estradiol see Estradiol 17-Ketosteroids WK 755 A 17-Oxosteroids see 17-Ketosteroids A Fibers see Nerve Fibers, Myelinated 17th Century History see History, 17th Century Aardvarks see Xenarthra 18th Century History see History, 18th Century Abate see Temefos 19th Century History see History, 19th Century Abattoirs WA 707 2',3'-Cyclic-Nucleotide Phosphodiesterases QU 136 Abbreviations 2,4-D see 2,4-Dichlorophenoxyacetic Acid Chemistry QD 7 2,4-Dichlorophenoxyacetic Acid General P 365-365.5 Organic chemistry QD 341.A2 Library symbols (U.S.) Z 881 2',5'-Oligoadenylate Polymerase see Medical W 13 2',5'-Oligoadenylate Synthetase By specialties (Form number 13 in any NLM -
Research Article Application Value of Mathematical Models of Diffusion-Weighted Magnetic Resonance Imaging in Differentiating Breast Cancer Lesions
Hindawi Evidence-Based Complementary and Alternative Medicine Volume 2021, Article ID 1481271, 8 pages https://doi.org/10.1155/2021/1481271 Research Article Application Value of Mathematical Models of Diffusion-Weighted Magnetic Resonance Imaging in Differentiating Breast Cancer Lesions Xiaolong Jiang, Chao Chen, Jie Liu, and Sheng Liu e Affiliated Nanhua Hospital, Department of Radiology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China Correspondence should be addressed to Sheng Liu; [email protected] Received 7 July 2021; Accepted 17 August 2021; Published 30 August 2021 Academic Editor: Songwen Tan Copyright © 2021 Xiaolong Jiang et al. ,is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. To determine the application value of the mono-exponential model, dual-exponential model, and stretched-exponential model of MRI with diffusion-weighted imaging (DWI) in breast cancer (BC) lesions. Methods. Totally 64 cases with BC admitted to our hospital between June 2019 and October 2020 were enrolled in this study. ,ey had 71 lesions in total, including 40 benign tumor lesions (including 9 breast cyst lesions) and 31 malignant tumor lesions. After DWI examination, with normal glands as control, mono-exponential model (ADC) map, dual-exponential model (Standard-ADC) map, slow apparent diffusion coefficient (Slow- ADC) map, fast-apparent diffusion coefficient (Fast-ADC) map, and stretched-exponential model (DDC) map were processed, and corresponding values were generated. ,en, the situation and significance of each parameter in breast cysts, benign breast tumor lesions, and malignant tumor lesions were analyzed.