Discovery of 318 New Risk Loci for Type 2 Diabetes and Related Vascular Outcomes Among 1.4 Million Participants in a Multi-Ancestry Meta-Analysis
ARTICLES https://doi.org/10.1038/s41588-020-0637-y Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis Marijana Vujkovic 1,2,112, Jacob M. Keaton3,4,5,6,112, Julie A. Lynch 7,8, Donald R. Miller9,10, Jin Zhou 11,12, Catherine Tcheandjieu13,14,15, Jennifer E. Huffman 16, Themistocles L. Assimes 13,14, Kimberly Lorenz 1,17,18, Xiang Zhu 13,19, Austin T. Hilliard 13,14, Renae L. Judy1,20, Jie Huang16,21, Kyung M. Lee 7, Derek Klarin 16,22,23,24, Saiju Pyarajan16,25,26, John Danesh27, Olle Melander28, Asif Rasheed29, Nadeem H. Mallick 30, Shahid Hameed30, Irshad H. Qureshi31,32, Muhammad Naeem Afzal31,32, Uzma Malik31,32, Anjum Jalal33, Shahid Abbas33, Xin Sheng 2, Long Gao17, Klaus H. Kaestner17, Katalin Susztak 2, Yan V. Sun 34,35, Scott L. DuVall 7,36, Kelly Cho16,25, Jennifer S. Lee13,14, J. Michael Gaziano16,25, Lawrence S. Phillips 34,37, James B. Meigs23,26,38, Peter D. Reaven 11,39, Peter W. Wilson34,40, Todd L. Edwards 4,41, Daniel J. Rader 2,17, Scott M. Damrauer 1,20, Christopher J. O’Donnell 16,25,26, Philip S. Tsao 13,14, The HPAP Consortium*, Regeneron Genetics Center*, VA Million Veteran Program*, Kyong-Mi Chang 1,2,42,112, Benjamin F. Voight 1,17,18,112 ✉ and Danish Saleheen 29,43,44,112 ✉ We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ancestry meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE, Biobank Japan and other studies.
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