Anti-Cav2.2 (Aa 851-867) Polyclonal Antibody (DPAB2869RM) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-CaV2.2 (aa 851-867) polyclonal antibody (DPAB2869RM) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Rabbit Anti-Mouse Calcium Channel, Voltage-Dependent, N Type, Alpha 1B Subunit Polyclonal Antibody. Recognizes the ~210 kDa and the ~240 kDa forms of α1B-subunit of Cav2.2. Supplied with a control peptide.

Antigen Description The N-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit forms the pore through which calcium enters the cell and determines most of the channel"s properties. The α1 subunit is also known as the calcium channel, voltage- dependent, N type, alpha 1B subunit (CACNA1B) or Cav2.2 which in humans is encoded by the CACNA1B gene.

Specificity Mouse; rat

Immunogen a synthetic peptide [(C)RHHRHRDRDKTSASTPA] corresponding to amino acids 851-867 of the α1B-subunit of rat brain voltage-gated calcium channels, conjugated to KLH

Isotype IgG

Source/Host Rabbit

Species Reactivity Rat

Conjugate Unconjugated

Applications IHC, ICC, IB, IP

Positive Control None

Format Liquid. 50 μl antibody lyophilized from PBS, 5% sucrose, 1% BSA, pH. 7.4 and 40 μg control peptide lyophilized from PBS.

Size 50 μl

Preservative ≤0.1% Sodium Azide

Storage -20℃

Ship Ambient Temperature Only Standard Handling

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Gene Name Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit [ Mus musculus ]

Synonyms Cacna1b; calcium channel, voltage-dependent, N type, alpha 1B subunit; Cav2.2; Cchn1a; AW050276; AW060892; AW822256; alpha(1B); voltage-dependent N-type calcium channel subunit alpha-1B; BIII; brain calcium channel III; calcium channel, L type, alpha-1 polypeptide; voltage-gated calcium channel subunit alpha Cav2.2; calcium channel, voltage-dependent, L type, alpha 1B subunit

Entrez Gene ID 774

Protein Refseq NP_001035993

UniProt ID Q00975

Chromosome Location 2 A2; 2 18.0cM

Pathway Calcium Regulation in the Cardiac Cell; Calcium signaling pathway; Cholinergic synapse; Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels; Dopaminergic synapse; GABAergic synapse; MAPK signaling pathway; Neuronal System; Serotonergic synapse; Synaptic vesicle cycle; Taste transduction; Transmission across Chemical Synapses; Type II diabetes mellitus.

Function calcium channel activity; ion channel activity; nucleotide binding; protein C-terminus binding; protein binding; voltage-gated calcium channel activity; voltage-gated ion channel activity

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]