Anti-CaV2.2 (aa 851-867) polyclonal antibody (DPAB2869RM) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Product Overview Rabbit Anti-Mouse Calcium Channel, Voltage-Dependent, N Type, Alpha 1B Subunit Polyclonal Antibody. Recognizes the ~210 kDa and the ~240 kDa forms of α1B-subunit of Cav2.2. Supplied with a control peptide. Antigen Description The N-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit forms the pore through which calcium enters the cell and determines most of the channel"s properties. The α1 subunit is also known as the calcium channel, voltage- dependent, N type, alpha 1B subunit (CACNA1B) or Cav2.2 which in humans is encoded by the CACNA1B gene. Specificity Mouse; rat Immunogen a synthetic peptide [(C)RHHRHRDRDKTSASTPA] corresponding to amino acids 851-867 of the α1B-subunit of rat brain voltage-gated calcium channels, conjugated to KLH Isotype IgG Source/Host Rabbit Species Reactivity Rat Conjugate Unconjugated Applications IHC, ICC, IB, IP Positive Control None Format Liquid. 50 μl antibody lyophilized from PBS, 5% sucrose, 1% BSA, pH. 7.4 and 40 μg control peptide lyophilized from PBS. Size 50 μl Preservative ≤0.1% Sodium Azide Storage -20℃ Ship Ambient Temperature Only Standard Handling 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved GENE INFORMATION Gene Name Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit [ Mus musculus ] Synonyms Cacna1b; calcium channel, voltage-dependent, N type, alpha 1B subunit; Cav2.2; Cchn1a; AW050276; AW060892; AW822256; alpha(1B); voltage-dependent N-type calcium channel subunit alpha-1B; BIII; brain calcium channel III; calcium channel, L type, alpha-1 polypeptide; voltage-gated calcium channel subunit alpha Cav2.2; calcium channel, voltage-dependent, L type, alpha 1B subunit Entrez Gene ID 774 Protein Refseq NP_001035993 UniProt ID Q00975 Chromosome Location 2 A2; 2 18.0cM Pathway Calcium Regulation in the Cardiac Cell; Calcium signaling pathway; Cholinergic synapse; Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels; Dopaminergic synapse; GABAergic synapse; MAPK signaling pathway; Neuronal System; Serotonergic synapse; Synaptic vesicle cycle; Taste transduction; Transmission across Chemical Synapses; Type II diabetes mellitus. Function calcium channel activity; ion channel activity; nucleotide binding; protein C-terminus binding; protein binding; voltage-gated calcium channel activity; voltage-gated ion channel activity 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.