DOCSLIB.ORG

Hydroxyethoxyphenyl Butanone’ (HEPB)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Hydroxyethoxyphenyl Butanone’ (HEPB) SCCS/1582/16 Final version Scientific Committee on Consumer Safety SCCS OPINION ON Ethylzingerone – ‘Hydroxyethoxyphenyl Butanone’ (HEPB) (Cosmetics Europe No P98) The SCCS adopted this Opinion by written procedure on 7 April 2017 SCCS/1582/16 Final Opinion on Ethylzingerone - ‘Hydroxyethoxyphenyl Butanone’ (HEPB) - Cosmetics Europe No P98 About the Scientific Committees Three independent non-food Scientific Committees provide the Commission with the scientific advice it needs when preparing policy and proposals relating to consumer safety, public health and the environment. The Committees also draw the Commission's attention to the new or emerging problems which may pose an actual or potential threat. They are: the Scientific Committee on Consumer Safety (SCCS), the Scientific Committee on Health and Environmental Risks (SCHER) and the Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR) and are made up of external experts. In addition, the Commission relies upon the work of the European Food Safety Authority (EFSA), the European Medicines Agency (EMA), the European Centre for Disease prevention and Control (ECDC) and the European Chemicals Agency (ECHA). SCCS The Committee shall provide Opinions on questions concerning all types of health and safety risks (notably chemical, biological, mechanical and other physical risks) of non-food consumer products (for example: cosmetic products and their ingredients, toys, textiles, clothing, personal care and household products such as detergents, etc.) and services (for example: tattooing, artificial sun tanning, etc.). Scientific Committee members Ulrike Bernauer, Laurent Bodin, Leonardo Celleno, Qasim Chaudhry, Pieter Jan Coenraads, Maria Dusinska, Janine Ezendam, Eric Gaffet, Corrado Lodovico Galli, Berit Granum, Eirini Panteri, Vera Rogiers, Christophe Rousselle, Maciej Stepnik, Tamara Vanhaecke, Susan Wijnhoven. Contact European Commission Health and Food Safety Directorate C: Public Health, Country Knowledge and Crisis Management Unit C2 – Country Knowledge and Scientific Committees Office: HTC 03/073 L-2920 Luxembourg [email protected] © European Union, 2017 ISSN 1831-4767 ISBN 978-92-79-81014-5 Doi:10.2875/59572 EW-AQ-18-003-EN-N The Opinions of the Scientific Committees present the views of the independent scientists who are members of the committees. They do not necessarily reflect the views of the European Commission. The Opinions are published by the European Commission in their original language only. http://ec.europa.eu/health/scientific_committees/consumer_safety/index_en.htm 2 SCCS/1582/16 Final Opinion on Ethylzingerone - ‘Hydroxyethoxyphenyl Butanone’ (HEPB) - Cosmetics Europe No P98 ACKNOWLEDGMENTS SCCS members listed below are acknowledged for their valuable contribution to the finalisation of this Opinion. SCCS Members Dr U. Bernauer (Rapporteur) Dr L. Bodin Prof. Q. Chaudhry Prof. P.J. Coenraads (Chairperson) Prof. M. Dusinska Dr J. Ezendam Prof. C. L. Galli Dr B. Granum Prof. E. Panteri Prof. V. Rogiers Dr Ch. Rousselle Dr M. Stepnik Prof. T. Vanhaecke Dr S. Wijnhoven The additional contribution for the drafting of the preliminary Opinion of former members of the SCCS (2013-2016) listed below is gratefully acknowledged. Former SCCS Member Dr. J. van Benthem Prof. G. H. Degen Prof. J. Duus-Johansen This Opinion has been subject to a commenting period of a minimum eight weeks after its initial publication (from 12 January until 10 March 2017). Comments received during this time were considered by the SCCS. For this Opinion, comments received resulted in the following changes: section 3.3.5.2. oral toxicity, and the further scientific concerns (point 3 of the conclusions) including on eye irritation. Keywords: SCCS, scientific opinion, Ethylzingerone - ‘Hydroxyethoxyphenyl Butanone’ (HEPB) - Cosmetics Europe No P98, Regulation 1223/2009, CAS 569646-79-3 Opinion to be cited as: SCCS (Scientific Committee on Consumer Safety), Opinion on Ethylzingerone - ‘Hydroxyethoxyphenyl Butanone’ (HEPB) - Cosmetics Europe No P98, SCCS/1582/16, 7 April 2017 3 SCCS/1582/16 Final Opinion on Ethylzingerone - ‘Hydroxyethoxyphenyl Butanone’ (HEPB) - Cosmetics Europe No P98 TABLE OF CONTENTS ACKNOWLEDGMENTS ........................................................................................... 3 1. BACKGROUND ............................................................................................. 6 2. TERMS OF REFERENCE .................................................................................. 6 3. OPINION ..................................................................................................... 7 3.1 Chemical and Physical Specifications ....................................................... 7 3.1.1 Chemical identity .................................................................... 7 3.1.2 Physical form ......................................................................... 8 3.1.3 Molecular weight .................................................................... 8 3.1.4 Purity, composition and substance codes .................................... 8 3.1.5 Impurities / accompanying contaminants ................................... 8 3.1.6 Solubility ............................................................................. 10 3.1.7 Partition coefficient (Log Pow) .................................................. 10 3.1.8 Additional physical and chemical specifications .......................... 10 3.1.9 Stability .............................................................................. 11 3.2 Function and uses .............................................................................. 11 3.3 Toxicological Evaluation ...................................................................... 11 3.3.1 Acute toxicity ....................................................................... 11 3.3.2 Irritation and corrosivity ........................................................ 12 3.3.3 Skin sensitisation .................................................................. 15 3.3.4 Toxicokinetics ...................................................................... 15 3.3.5 Repeated dose toxicity .......................................................... 18 3.3.6 Reproductive toxicity ............................................................. 21 3.3.7 Mutagenicity / Genotoxicity .................................................... 22 3.3.8 Carcinogenicity ..................................................................... 26 3.3.9 Photo-induced toxicity ........................................................... 26 3.3.10 Human data ......................................................................... 27 3.3.11 Special investigations ............................................................ 27 3.4 Exposure assessment ......................................................................... 28 3.5 Safety evaluation (including calculation of the MoS) ................................ 28 3.6 Discussion ........................................................................................ 30 4. CONCLUSION ............................................................................................ 33 5. MINORITY OPINION .................................................................................... 33 6. REFERENCES ............................................................................................. 34 4 SCCS/1582/16 Final Opinion on Ethylzingerone - ‘Hydroxyethoxyphenyl Butanone’ (HEPB) - Cosmetics Europe No P98 1. BACKGROUND Ethylzingerone with INCI name ‘Hydroxyethoxyphenyl Butanone’ (HEPB) Cosmetics Europe No P98 - CAS No 569646-79-3 is a cosmetic ingredient not regulated under Cosmetic Regulation No 1223/2009 with the function as skin conditioning agent. In September 2015, the Commission' services received a dossier from industry to support the safe use of Hydroxyethoxyphenyl Butanone (HEPB) when used as preservative in rinse-off, oral care and leave-on cosmetic products. According to the above-mentioned dossier the safety profile of HEPB has been studied in preclinical studies conducted according to Good Laboratory Practices and following OECD guidelines whenever available. They were conducted using HEPB from batches which were well characterized analytically with a minimum purity of 95.9%. 2. TERMS OF REFERENCE (1) In light of the data provided, does the SCCS consider safe the use of Hydroxyethoxyphenyl Butanone (HEPB) as a cosmetic preservative in rinse-off, oral care and leave-on cosmetic products with a maximum concentration of 2.0 % under an aggregate exposure scenario for cosmetics? (2) Alternatively, what is according to the SCCS, the maximum target concentration considered safe for use of Hydroxyethoxyphenyl Butanone (HEPB) as a cosmetic preservative in rinse-off, oral care and leave-on cosmetic products under an aggregate exposure scenario for cosmetics? (3) Does the SCCS have any further scientific concerns regarding the use of Hydroxyethoxyphenyl Butanone (HEPB) in cosmetic products? 5 SCCS/1582/16 Final Opinion on Ethylzingerone - ‘Hydroxyethoxyphenyl Butanone’ (HEPB) - Cosmetics Europe No P98 3. OPINION 3.1 Chemical and Physical Specifications 3.1.1 Chemical identity 3.1.1.1 Primary name and/or INCI name Hydroxyethoxyphenyl butanone (INCI) 3.1.1.2 Chemical names 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one 3.1.1.3 Trade names and abbreviations Ethylzingerone R0069279A HEPB SCCS comment For convenience, the abbreviation HEPB will be used throughout the Opinion. 3.1.1.4 CAS
Load more

Recommended publications
  • Toxicological Profile for 2-Butanone Released for Public Comment in May 2019
    Toxicological Profile for 2-Butanone October 2020 2-BUTANONE ii DISCLAIMER Use of trade names is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry, the Public Health Service, or the U.S. Department of Health and Human Services. 2-BUTANONE iii FOREWORD This toxicological profile is prepared in accordance with guidelines* developed by the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA). The original guidelines were published in the Federal Register on April 17, 1987. Each profile will be revised and republished as necessary. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for these toxic substances described therein. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicologic properties. Other pertinent literature is also presented, but is described in less detail than the key studies. The profile is not intended to be an exhaustive document; however, more comprehensive sources of specialty information are referenced. The focus of the profiles is on health and toxicologic information; therefore, each toxicological profile begins with a relevance to public health discussion which would allow a public health professional to make a real-time determination of whether the presence of a particular substance in the environment poses a potential threat to human health. The adequacy of information to determine a substance's
    [Show full text]
  • Critical Evaluation of Thermochemical Properties of C1–C4 Species; Updated Group-Contributions to Estimate Thermochemical Properties
    Provided by the author(s) and NUI Galway in accordance with publisher policies. Please cite the published version when available. Critical evaluation of thermochemical properties of C-1-C-4 Title species: updated group-contributions to estimate thermochemical properties Author(s) Burke, S. M.; Simmie, J. M.; Curran, Henry J. Publication Date 2015-01-05 Burke, S. M., Simmie, J. M., & Curran, H. J. (2015). Critical Publication evaluation of thermochemical properties of C-1-C-4 species: Information updated group-contributions to estimate thermochemical properties. Journal of Physical and Chemical Reference Data, 44(1), 013101. Publisher AIP Publishing Link to publisher's http://dx.doi.org/10.1063/1.4902535 version Item record http://hdl.handle.net/10379/6119 DOI http://dx.doi.org/10.1063/1.4902535 Downloaded 2021-09-25T06:51:18Z Some rights reserved. For more information, please see the item record link above. C1–C4 thermochemical properties: updated group additivity groups Critical evaluation of thermochemical properties of C1–C4 species; updated group-contributions to estimate thermochemical properties. S. M. Burke, J. M. Simmie, and H. J. Currana) Combustion Chemistry Centre, National University of Ireland, Galway, Ireland (Dated: 26 September 2014) A review of literature enthalpies of formation and molar entropies for alkanes, alkenes, alcohols, hydroperox- ides, and their associated radicals has been compiled and critically evaluated. By comparing literature values the overall uncertainty in thermochemical properties of small hydrocarbons and oxygenated hydrocarbons can be highlighted. In general there is good agreement between heat of formation values in the literature for stable species, however there is greater uncertainty in the values for radical species and for molar entropy values.
    [Show full text]
  • Appendix D MEK Product Brochure
    Appendix D MEK Product Brochure PRODUCT DESCRIPTION 1 of 2 Methyl Ethyl Ketone (2-Butanone, MEK) O ll MW = 72.11 CH3CCH2CH3 Methyl Ethyl Ketone, Chemical Abstracts Registry Number 78-93-3 Wiswesser Line Formula Chemical Notation 2V1 Methyl Ethyl Ketone (MEK) is a accounts for its largest use. Other important applications are as clear, colorless, low-boiling organ- Nitrocellulose lacquers consume an extraction solvent for the ic liquid with a typical ketone large volumes of Methyl Ethyl dewaxing of lube oil and as an odor. It is a fast evaporating sol- Ketone and solubilization of intermediate in the production of vent with an evaporation rate simi- acrylic coatings also contributes to antioxidants, perfumes and cata- lar to ethyl acetate. Although not the overall use of Methyl Ethyl lysts. Methyl Ethyl Ketone is also as volatile as acetone, Methyl Ketone by the surface coatings used by the hard wood pulping Ethyl Ketone is similar to acetone industry. MEK is preferred as a industry and in the production of in many respects. It is miscible lacquer solvent, because high con- smokeless powder. It is routinely with most organic solvents and is centrations of resins possessing used in printing inks, degreasing an excellent solvent for most natu- superior aliphatic and aromatic and cleaning fluids and as a com- ral and synthetic resins. diluent tolerance can be readily ponent of the solvent system used achieved as low viscosity solu- in producing magnetic tape. Methyl Ethyl Ketone is a highly tions. versatile organic compound but Methyl Ethyl Ketone as a chemi- finds its greatest utility as a sol- Methyl Ethyl Ketone is also com- cal intermediate will undergo the vent in the surface coatings indus- monly used as a solvent for rubber typical reactions associated with try.
    [Show full text]
  • Methyl Ethyl Ketone
    Shell Chemicals Technical Datasheet Methyl Ethyl Ketone Product Code S2113 Region Global Product Category Ketones CAS Registry Number 78-93-3 Synonym(s) 2-Butanone, MEK Description Methyl ethyl ketone, MEK, a low boiling, fast evaporating solvent is a Methyl ethyl ketone, MEK, is a low boiling, fast evaporating solvent colourless, stable liquid, partially miscible with water. MEK has exceptionally good solvency for many synthetic and natural resins that are used in the formulation of printing inks, lacquers, and other types of coatings. Typical Properties Property Unit Method Value Purity, min. %m/m GC 99.5 Water %m/m ASTM D1364 0.03 Acidity (as Acetic Acid) %m/m ASTM D1613 0.002 Density at 20°C kg/l ASTM D4052 0.805 Specific Gravity at 20°C/20°C - ASTM D4052 0.806 Specific Gravity at 25°C/25°C - ASTM D4052 0.802 Coefficient of Cubic Expansion at 20°C 10-4/°C Calculated 13 Refractive Index at 20°C - ASTM D1218 1.379 Colour Pt-Co ASTM D1209 < 5 Boiling Point °C - 80 Relative Evaporation Rate (nBuAc=1) - ASTM D3539 4.0 Relative Evaporation Rate (Ether=1) - DIN 53170 3.3 Antoine Constant A # kPa. °C - 6.18444 Antoine Constant B # kPa. °C - 1259.22 Antoine Constant C # kPa. °C - 221.758 26 Methyl Ethyl Ketone March 2016 Temperature Limits for Antoine Equation # °C - -40 to +90 Vapour Pressure at 20°C kPa Calculated 9.5 Vapour Pressure at 50°C kPa Calculated 36 Saturated Vapor Concentration at 20°C g/m3 Calculated 280 Volatile Organic Compound (VOC) g/l EU / EPA 805 Flash Point (Abel) °C IP 170 -6 Auto Ignition Temperature °C ASTM E659 515
    [Show full text]
  • How to Use This Guide Dielectric Constant Table
    Dielectric Constant Table.xls Dielectric Constant Table Dielectric Constant (k) is a number relating the ability of a material to carry alternating current to the ability of vacuum to carry alternating current. The capacitance created by the presence of the material is directly related to the Dielectric Constant of the material. Alphabetic Table A B C D Knowing the Dielectric Constant (k) of a material is needed to properly E F G H design and apply instruments such as level controls using radar, RF I J K L admittance, or capacitance technologies. There are also analytical M N O P reasons to know the (k) of a material. Q R S T U V W X How to use this guide Y Z # CLIPPER CONTROLS has compiled an extensive list of products with Dielectric Constants. Many of these Dielectric Constants are given at specific temperatures. If your product's temperature is significantly different from those listed there is a good chance that the Dielectric Constant may be different from the values listed. The products in this reference are listed in alphabetical order and are grouped in sections by the first letter of their name. Proper chemical names were used, and any trade names are the trademark of their respective owners. If you know the correct spelling of the name of the product you wish to review then use the "Search" feature on the web browser to locate the name in the list. You may also click on the letter from the alphabetical table to go directly to the beginning of that alphabetic section.
    [Show full text]
  • Compilation and Analysis of Types and Concentrations of Airborne 3 Chemicals Measured in Various Indoor and Outdoor Human 4 Environments 5 6 7 8 9 1 2 10 J
    Chemosphere,127,70-86,2015 1 2 Compilation and Analysis of Types and Concentrations of Airborne 3 Chemicals Measured in Various Indoor and Outdoor Human 4 Environments 5 6 7 8 9 1 2 10 J. Enrique Cometto-Muñiz and Michael H. Abraham 11 1 12 University of California, San Diego, La Jolla, California, USA and 2 13 Department of Chemistry, University College London, London, UK 14 15 16 17 18 19 20 Address for correspondence: 21 22 J. Enrique Cometto-Muñiz, Ph.D. 23 Research Scientist Emeritus, UCSD 24 8950 Villa La Jolla Drive, Suite C135 25 La Jolla, CA 92037 26 USA 27 28 29 Phone: (858) 622-5832 30 e-mail: [email protected] 31 32 33 34 35 36 37 38 39 40 Running head: Airborne Chemical Concentrations Indoors and Outdoors 41 1 41 Abstract 42 43 The main purpose of this article is to summarize and illustrate the results of a literature search on 44 the types, levels, relative concentrations, concentration spread of individual chemicals, and number of 45 airborne compounds (mostly volatile organic compounds, VOCs) that have been found, measured, and 46 reported both indoors and outdoors. Two broad categories of indoor environments are considered: 1) 47 Home/School, and 2) Commercial spaces. Also, two categories of outdoor environments are considered: 48 1) Non-industrial and 2) Industrial (the latter represented by the vicinity of a pig farm and the vicinity of an 49 oil refinery). The outcome is presented as a series of graphs and tables containing the following statistics: 50 geometric mean, arithmetic mean, median, standard deviation, variance, standard error, interquartile 51 distance, minimum value, maximum value, and number of data (data count) for the air concentration of 52 each reported compound in a given environment.
    [Show full text]
  • Dielectric Constant Chart
    Dielectric Constants of Common Materials DIELECTRIC MATERIALS DEG. F CONSTANT ABS RESIN, LUMP 2.4-4.1 ABS RESIN, PELLET 1.5-2.5 ACENAPHTHENE 70 3 ACETAL 70 3.6 ACETAL BROMIDE 16.5 ACETAL DOXIME 68 3.4 ACETALDEHYDE 41 21.8 ACETAMIDE 68 4 ACETAMIDE 180 59 ACETAMIDE 41 ACETANILIDE 71 2.9 ACETIC ACID 68 6.2 ACETIC ACID (36 DEGREES F) 36 4.1 ACETIC ANHYDRIDE 66 21 ACETONE 77 20.7 ACETONE 127 17.7 ACETONE 32 1.0159 ACETONITRILE 70 37.5 ACETOPHENONE 75 17.3 ACETOXIME 24 3 ACETYL ACETONE 68 23.1 ACETYL BROMIDE 68 16.5 ACETYL CHLORIDE 68 15.8 ACETYLE ACETONE 68 25 ACETYLENE 32 1.0217 ACETYLMETHYL HEXYL KETONE 66 27.9 ACRYLIC RESIN 2.7 - 4.5 ACTEAL 21 3.6 ACTETAMIDE 4 AIR 1 AIR (DRY) 68 1.000536 ALCOHOL, INDUSTRIAL 16-31 ALKYD RESIN 3.5-5 ALLYL ALCOHOL 58 22 ALLYL BROMIDE 66 7 ALLYL CHLORIDE 68 8.2 ALLYL IODIDE 66 6.1 ALLYL ISOTHIOCYANATE 64 17.2 ALLYL RESIN (CAST) 3.6 - 4.5 ALUMINA 9.3-11.5 ALUMINA 4.5 ALUMINA CHINA 3.1-3.9 ALUMINUM BROMIDE 212 3.4 ALUMINUM FLUORIDE 2.2 ALUMINUM HYDROXIDE 2.2 ALUMINUM OLEATE 68 2.4 1 Dielectric Constants of Common Materials DIELECTRIC MATERIALS DEG. F CONSTANT ALUMINUM PHOSPHATE 6 ALUMINUM POWDER 1.6-1.8 AMBER 2.8-2.9 AMINOALKYD RESIN 3.9-4.2 AMMONIA -74 25 AMMONIA -30 22 AMMONIA 40 18.9 AMMONIA 69 16.5 AMMONIA (GAS?) 32 1.0072 AMMONIUM BROMIDE 7.2 AMMONIUM CHLORIDE 7 AMYL ACETATE 68 5 AMYL ALCOHOL -180 35.5 AMYL ALCOHOL 68 15.8 AMYL ALCOHOL 140 11.2 AMYL BENZOATE 68 5.1 AMYL BROMIDE 50 6.3 AMYL CHLORIDE 52 6.6 AMYL ETHER 60 3.1 AMYL FORMATE 66 5.7 AMYL IODIDE 62 6.9 AMYL NITRATE 62 9.1 AMYL THIOCYANATE 68 17.4 AMYLAMINE 72 4.6 AMYLENE 70 2 AMYLENE BROMIDE 58 5.6 AMYLENETETRARARBOXYLATE 66 4.4 AMYLMERCAPTAN 68 4.7 ANILINE 32 7.8 ANILINE 68 7.3 ANILINE 212 5.5 ANILINE FORMALDEHYDE RESIN 3.5 - 3.6 ANILINE RESIN 3.4-3.8 ANISALDEHYDE 68 15.8 ANISALDOXINE 145 9.2 ANISOLE 68 4.3 ANITMONY TRICHLORIDE 5.3 ANTIMONY PENTACHLORIDE 68 3.2 ANTIMONY TRIBROMIDE 212 20.9 ANTIMONY TRICHLORIDE 166 33 ANTIMONY TRICHLORIDE 5.3 ANTIMONY TRICODIDE 347 13.9 APATITE 7.4 2 Dielectric Constants of Common Materials DIELECTRIC MATERIALS DEG.
    [Show full text]
  • Oligoetherols Based on Melamine–Formaldehyde–Butanone Resins
    Polym. Bull. DOI 10.1007/s00289-016-1802-4 ORIGINAL PAPER Oligoetherols based on melamine–formaldehyde– butanone resins Dorota Głowacz-Czerwonka1 Received: 3 January 2016 / Revised: 1 June 2016 / Accepted: 1 September 2016 Ó The Author(s) 2016. This article is published with open access at Springerlink.com Abstract New oligoetherols with 1,3,5-triazine ring were obtained from melamine– formaldehyde–butanone resins using 12 molar excess propylene oxide (with respect to the amount of introduced melamine). The resins were obtained from melamine solu- tions in reactive solvent obtained from simple chemical compound—methyl ethyl ketone (butan-2-one) in its reaction with 3 molar excess formaldehyde. Physical and chemical properties of obtained oligoetherols were determined and their structure was confirmed on the basis of proton magnetic resonance, infrared spectral data and MALDI-ToF mass analysis. The amount of by-products was specified on the basis of chromatographic analysis. Initial tests proved that obtained oligoetherols can constitute a potential substrate for obtaining polyurethane foams of increased thermal resistance. Keywords Oligoetherols Á Reactive solvent Á Melamine Á Propylene oxide Á Melamine–formaldehyde–butanone resins Introduction The currently known methods of obtaining oligoetherols, which may constitute substrates for creating heat-resistant polyurethane foams, are in majority based on melamine reactions (Mel) isocyanuric acid (or their selected derivatives) with oxiranes or alkylene carbonates [1]. Insertion of azacyclic rings into the polymer structure is difficult due to weak solubility of their compounds in organic solvents. One of such rings is (present in the melamine structure) 1,3,5-triazine (s-triazine) ring. Its presence results in high heat resistance of melamine and raises the temperature of decomposition to 360 °C.
    [Show full text]
  • Toxicological Profile for 2-Butanone
    2-BUTANONE 64 CHAPTER 4. CHEMICAL AND PHYSICAL INFORMATION 4.1 CHEMICAL IDENTITY Data pertaining to the chemical identity of 2-butanone are listed in Table 4-1. Table 4-1. Chemical Identity of 2-Butanone Characteristic Information Reference Chemical name 2-Butanone CAS 1989 Synonym(s) and registered Methyl ethyl ketone; MEK; ethyl methyl CAS 1989; SANSS 1989; trade name(s) ketone; methyl acetone; and others; Chemline 1989; OHM/TADS Meetco 1989 Chemical formula C4H8O CAS 1989 Chemical structure O 3CH C C CH3 H 2 CAS Registry Number 78-93-3 CAS 1989 CAS = Chemical Abstracts Service 4.2 PHYSICAL AND CHEMICAL PROPERTIES The physical and chemical properties of 2-butanone are presented in Table 4-2. Table 4-2. Physical and Chemical Properties of 2-Butanone Property Information Reference Molecular weight 72.11 Weast et al. 1988 Color Colorless Sax and Lewis 1987 Physical state Liquid Sax and Lewis 1987 Melting point -86.3°C Weast et al. 1988 Boiling point 79.6°C Weast et al. 1988 Density (liquid) at 20°C 0.8054 Weast et al. 1988 Odor Acetone-like Sax and Lewis 1987 Odor threshold: Water 8.4 ppm Amoore and Hautala 1983 Air 5.4 ppm Amoore and Hautala 1983 2-BUTANONE 65 4. CHEMICAL AND PHYSICAL INFORMATION Table 4-2. Physical and Chemical Properties of 2-Butanone Property Information Reference Solubility: Water at 25°C 136,000 mg/L Tewari et al. 1982 Organic solvents Benzene, alcohol, ether, oils, most Sax and Lewis 1987; Neier and organic solvents Strehlke 1985 Partition coefficients: Log Kow 0.29 Hansch et al.
    [Show full text]
  • Safety Data Sheet Dow Silicones Corporation
    SAFETY DATA SHEET DOW SILICONES CORPORATION Product name: DOWSIL™ PR-1205 Prime Coat Issue Date: 07/17/2020 Print Date: 07/18/2020 DOW SILICONES CORPORATION encourages and expects you to read and understand the entire (M)SDS, as there is important information throughout the document. We expect you to follow the precautions identified in this document unless your use conditions would necessitate other appropriate methods or actions. 1. IDENTIFICATION Product name: DOWSIL™ PR-1205 Prime Coat Recommended use of the chemical and restrictions on use Identified uses: Adhesive, binding agents COMPANY IDENTIFICATION DOW SILICONES CORPORATION 2200 WEST SALZBURG ROAD MIDLAND MI 48686-0994 UNITED STATES Customer Information Number: 800-258-2436 [email protected] EMERGENCY TELEPHONE NUMBER 24-Hour Emergency Contact: 1 800 424 9300 Local Emergency Contact: 800-424-9300 2. HAZARDS IDENTIFICATION Hazard classification GHS classification in accordance with 29 CFR 1910.1200 Flammable liquids - Category 2 Skin irritation - Category 2 Eye irritation - Category 2A Reproductive toxicity - Category 2 Specific target organ toxicity - single exposure - Category 3 Specific target organ toxicity - repeated exposure - Category 2 - Inhalation Aspiration hazard - Category 1 Label elements Hazard pictograms ® ™ Trademark of The Dow Chemical Company ("Dow") or an affiliated Page 1 of 20 company of Dow Product name: DOWSIL™ PR-1205 Prime Coat Issue Date: 07/17/2020 Signal word: DANGER! Hazards Highly flammable liquid and vapour. May be fatal if swallowed and enters airways. Causes skin irritation. Causes serious eye irritation. May cause drowsiness or dizziness. Suspected of damaging fertility or the unborn child. May cause damage to organs (Nervous system) through prolonged or repeated exposure if inhaled.
    [Show full text]
  • Department of Chemistry SURFACE TENSION of LIQUID
    Department of Chemistry SURFACE TENSION OF LIQUID BINARY MIXTURES AT DIFFERENT TEMPERATURES (FROM 298.15K TO 318.15K) By: LESEDI RATSATSI ID NO: 200701420 A THESIS SUBMITTED IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE IN CHEMISTRY OF THE UNIVERSITY OF BOTSWANA Supervisor: Professor Jamil Ahmad June 2016 CERTIFICATION The undersigned certify that they have read and hereby recommend for the acceptance by the Department of Chemistry, University of Botswana, a Thesis entitled “SURFACE TENSION OF LIQUID BINARY MIXTURES AT DIFFERENT TEMPERATURES (FROM 298.15K TO 318.15K)” as part of the work recommended in fulfillment of the requirements for a Master degree in chemistry at the University of Botswana. Supervisor ………………………………………… Date……………… Internal examiner…………………………………. Date……………… External examiner…………………………………. Date….………...... ii DECLARATION AND COPYRIGHT I hereby declare that the dissertation/thesis submitted for the degree of M.Sc. Physical Chemistry to the University of Botswana, is my own original work and has not previously been submitted to any other institution and any work quoted is indicated and acknowledged by means of a comprehensive list of references. …………………………………………… Lesedi Ratsatsi …………………… Date Copyright© University of Botswana 2016 iii DEDICATION I dedicate this to my mom Agnes Ratsatsi and my family for being my strength when I was weak. iv ACKNOWLEDGEMENTS I would like to extend my gratitude to the Almighty God for remaining my strength and light, my supervisor Professor Jamil Ahmad for the patience and guidance throughout the course of this project, Dr W. Ddamba for further help to tighten my explanations and Thesis. The Department of Chemistry for making this possible with the guidance and the financial support, the warmth they gave me to enjoy working here.
    [Show full text]
  • Introduction Detected Compounds (Refer to Attached Testing Results and “Reference Map for Sampling Data”) Benzene
    Introduction This handout provides supporting information to the attached analytical results. The information below is targeted towards exposure of these compounds in drinking water sources. While there is information available on exposure to these compounds in occupational settings, information can be limited on the presence of these compounds in drinking water. Where possible, the City of San Angelo (City) has provided information related to the presence of these compounds in drinking water rather than exposure in an occupational setting. Analytical results accompanying this handout present the findings from sampling conducted through Thursday, February 11th by the City and the Texas Commission on Environmental Quality (TCEQ). The City has collected 52 individual samples over 4 sampling events in addition to TCEQ performing their own sampling. No abnormal test results have been detected in San Angelo’s system outside of the PaulAnn subdivision and the adjacent industrial area. Units of Measurement-Parts Per Billion There are 1,000 million in a billion. Parts per billion also can be expressed as micrograms per liter (ug/L). This measurement is the mass of a chemical or contaminate per unit volume of water. Seeing ppb or ug/L on a lab report means the same thing. Analytical results accompanying this handout are all measured in parts per billion. To put the measurement of ppb or ug/L into perspective the following analogies are used: One ppb is equivalent to: • One inch in 15,783 miles, or • One second in 31.7 years. Detected Compounds (Refer to attached testing results and “Reference Map for Sampling Data”) Benzene Maximum contaminant level in drinking water: 5 ug/L Benzene is a clear, colorless, highly flammable and volatile, liquid aromatic hydrocarbon with a gasoline- like odor.
    [Show full text]