Cumulative List of all Products that have received Orphan Designation: Total active designations: 2002 Effecive: 5/5/2009 Generic Name Trade Name Designated Indication treatmentMarketing and/or Approved modification Indication of the Designated Date Market Exculsivity Date following conditions, which are Vaccinia Immune Globulin complications resulting from smallpox (Human) Intravenous CNJ-016 ForTreatment the control of complications and prevention of vacciniaof hemorrhagic vaccination episodes vaccination: Eczema vaccinatum 18.06.2004 01.05.9999 and for surgical prophylaxis in patients with hemophilia Antihemophilic factor A (congenital factor VIII deficiency or classic (recombinant) ReFacto hemophilia). 08.02.1996 01.01.9999 For use as a thyroid blocking agent in For use as a thyroid blocking agent in pediatric patients pediatric patients exposed to Potassium Iodide Oral Solution ThyroShield exposed to radiactive iodine radiactive iodine 17.11.2004 01.01.9999 Treatment (rescue) of respiratory Pulmonary surfactant For the treatment and prevention of respiratory distress distress syndrome in premature replacement, porcine Curosurf syndrome in premature infants. Longinfants. term treatment of children with 02.08.1993 01.01.9999 growth failure due to inadequate Treatment of idiopathic or organic growth hormone secretion of endogenous growth Somatropin (rDNA origin) Saizen deficiency in children with growth failure. Long-termhormone. treatment of growth failure 06.03.1987 01.01.9999 Long-term treatment of children who have growth failure due to a lack of adequate endogenous due to a lack of adequate endogenous growth hormone growth hormone secetion for once- or Somatropin (rDNA origin) Nutropin Depot secretion. twice-a-month administration. 28.10.1999 01.01.9999 Treatment of growth failure in children due to have growth failure due to inadequate Somatropin (rDNA origin) injection Norditropin inadequate growth hormone secretion. Treatmentsecretion of and endogenous prevention growth of 10.07.1987 01.01.9999 respiratory failure due to pulmonary Surface active extract of saline Treatment and prevention of respiratory failure due to surfactant deficiency in preterm lavage of bovine lungs Infasurf pulmonary surfactant deficiency in preterm infants. Forinfants. use as an aid in ophthalmic 07.06.1985 01.01.9999 surgery by staining the epiretinal Selectively staining epiretinal membranes during membranes during ophthalmic Trypan blue MembraneBlue Treatmentophthalmic of surgical congenital victrectomy antithrombin procedures deficiency to Preventionsurgical vitrectomy of peri-operative procedures, and peri- 02.08.2006 20.02.2009 prevent the occurrence of serious, potentially life- partum thromboembolic events, in threatening venous thromboembolisms which may hereditary antithrombin deficient Recombinant human antithrombin ATryn develop as a result of surgical or obstetrical procedures Treatmentpatients. of acute bleeding episodes 07.12.2007 06.02.2009 in patients with congenital fibrinogen human fibrinogen concentrate, deficiency (afibrinogenemia and pasteurized RiaSTAP Treatment of fibrinogen deficient patients Treatmenthypofibrinogenemia of adult patients with B-cell 13.03.2008 16.01.2009 chronic lymphocytic leukemia (CLL) whose disease has not responded to Fludarabine phosphate oral tablets ForTreatment use to improveof B-cell thechronic yield lymphocytic of progentor leukemia cells in the Toor hasenhance progressed mobilization during of or after 18.12.2007 18.12.2008 apheresis product for subsequest stem cell hematopoietic stem cells to the transplantation following myelosuppressive or peripheral blood for collection and plerixafor Mozobil myeloablative chemotherapy Treatmentsubsequent of autologous thrombocytopenia in 10.07.2003 15.12.2008 patients with chronic immune eltrombopag Promacta Treatment of idiopathic thrombocytopenia purpura (idiopathic) thrombocytopenic purpura 05.05.2008 20.11.2008 Adjunctive therapy of seizures associated with Lennox-Gastaut rufinamide Banzel Treatment of Lennox-Gastaut Syndrome. syndrome. 08.10.2004 14.11.2008 Routine prophylaxis against angioedema attacks in patients with C1 esterase inhibitor (human) Cinryze Treatment of angioedema Hereditary Angioedema (HAE) 16.07.2004 10.10.2008

To be used in the detection of primary or metastatic pheochromocytomas or neuroblastomas as an adjunct to other Iobenguane I 123 AdreView For the diagnosis of pheochromocytomas diagnostic tests 01.12.2006 19.09.2008

To be used in the detection of primary or metastatic pheochromocytomas or neuroblastomas as an adjunct to other Iobenguane I 123 Adreview For the diagnosis of neuroblastomas diagnostic tests 01.12.2006 19.09.2008 Treatment of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) to improve neuromuscular disability Treatment of chronic inflammatory demyelinating and impairment and for maintenance Immune Globulin (Human) Gamunex polyneuropathy Treatmenttherapy to preventof thrombocytopenia relapse in 27.07.2004 12.09.2008 patients with chronic immune (idiopathic) thrombocytopenic purpura romiplstim Nplate Treatment of immune thrombocytopenic purpura (ITP) who have had an insufficient 27.03.2003 22.08.2008

Treatment of chorea associated with Tetrabenazine Xenazine Treatment of Huntington's disease Huntington's disease 11.12.1997 15.08.2008

Treatment of unresectable Sorafenib Nexavar Treatment of hepatocellular carcinoma hepatocellular carcinoma 20.04.2006 24.03.2008

Treatment of patients with chronic Bendamustine hydrochloride Treanda Treatment of chronic lymphocytic leukemia Levoleucovorinlymphocytic leukemia rescue is indicated 17.08.2007 20.03.2008 after high-dose methotrexate therapy For use in conjunction with high-dose methotrexate in in osteosarcoma. Levoleucovorin is Levoleucovorin the treatment of osteosarcoma. also indicated to diminish the toxicity 01.08.1991 07.03.2008

Treatment of Cryopyrin-Assisted Rilonacept Arcalyst Treatment of CIAS1-Associated Periodic Syndromes Periodic Syndromes (CAPS) 20.12.2004 27.02.2008

Treatment of Juvenile Idiopathic Adalimumab Humira Treatment of juvenile rheumatoid arthritis Arthritis 21.03.2005 21.02.2008 For use as an adjunctive treatment for radioiodine ablation of thyroid tissue Treatment of well-differentiated papillary, follicular or remnants in patients who have Thyrotropin alfa Thyrogen combined papillary/follicular carcinomas of the thyroid Indicatedundergone to thyroidectomy reduce blood for well- 03.08.2001 14.12.2007 phenylalanine (Phe) levels in patients with hyperphenylalaninemia (HPA) sapropterin Kuvan Treatment of hyperphenylalaninemia Fordue theto tetrahydrobiopterin- use for chronic phase (BH4-) (CP) 29.01.2004 13.12.2007 and accelerated phase (AP) Philadelphia chromosome positive Nilotinib Tasigna Treatment of chronic myelogenous leukemia Reductionchronic myelogenous in risk of invasive leukemia breast (CML) 27.04.2006 29.10.2007 cancer in postmenopausal women Reduction of the risk of breast cancer in with osteoporosis and reduction in risk Raloxifene Evista postmenopausal women of invasive breast cancer in 14.07.2005 13.09.2007

Treatment of anthracycline extravasation during Treatment of extravasation resulting dexrazoxane Totect chemotherapy Long-termfrom IV anthracycline treatment of chemotherapy acromegalic 25.03.2004 06.09.2007 patients who have had an inadequate response to or cannot be treated with Lanreotide Somatuline Depot Treatment for acromegly Treatmentsurgery and/or of pulmonary radiotherapy arterial 11.09.2000 30.08.2007 hypertension (WHO group I) in patients with WHO class II or III ambrisentan Letairis Treatment of pulmonary arterial hypertension symptoms to improve exercise 16.07.2004 15.06.2007

Treatment of short stature in patients with Noonan Treatment of short stature in patients Somatropin Norditropin syndrome with Noonan syndrome 09.08.2006 31.05.2007

Treatment of advanced renal cell Temsirolimus Torisel Treatment of renal cell carcinoma Forcarcinoma use in combination with 16.12.2004 30.05.2007 bortezomib for the treatment of Doxorubicin HCL liposome patients with multiple myeloma who injection Doxil Treatment of multiple myeloma have not previously received 29.12.2004 17.05.2007

Treatment of central precocious Histrelin Supprelin LA Treatment of central precocious puberty Preventionpuberty of hepatitis B recurrence 18.11.2005 03.05.2007 following liver transplantation in hepatitis B immune globulin Prevention of hepatitis B recurrence following orthotopic HBsAG-positive liver transplant (human) HepaGam liver transplant patients 24.03.2008 06.04.2007 For replacement therapy in congenital protein C deficiency for the prevention and treatment of Prevention and treatment of venous Protein C concentrate Ceprotin thrombosis, pulmonary emboli, and purpura fulminans. thrombosis and purpura fulminans 23.06.1992 30.03.2007

Treatment of paroxysmal nocturnal eculizumab Soliris Treatment of paroxysmal nocturnal hemoglobinuria hemoglobinuria to reduce hemolysis 20.08.2003 16.03.2007 For surgical and/or invasive procedures in patients with von Willebrand Disease (VWD) in whom Antihemophilic factor (human) Alphanate Treatment of von Willebrand's disease Treatmentdesmopressin of mildly is either to moderately ineffective or 05.01.1996 31.01.2007 active ulcerative colitis in patients 5 years of age and older. Safety and Balsalazide disodium Colazal Treatment of pediatric patients with ulcerative colitis Effectiveness of Colazal beyond 8 12.08.2005 20.12.2006

Treatment on known or suspected Hydroxocobalamin Cyanokit Treatment of acute cyanide poisoning cyanide poisoning 25.11.2003 15.12.2006 Treatment of adult patients with aggressive mastocytosis (ASM) Treatment of systemic mastocytosis without the D816V without the D816V c-Kit mutation or Imatinib mesylate Gleevec c-kit mutation Treatmentwith c-Kit mutational of adult patients status unknownwith 09.09.2005 19.10.2006 Treatment of myeloproliferative myelodysplastic/myeloproliferative disorders/myelodysplastic syndromes associated with diseases (MDS/MPD) associated with Imatinib mesylate Gleevec platelet-derived growth factor gene re-arrangements TreatmentPDGFR (platelet-derived of adult patients growth with factor 05.10.2005 19.10.2006 hypereosinophic syndrome (HES) Treatment of idiopathic hypereosinophilic syndrome and/or chronic eosinophilic leukemia Imatinib mesylate Gleevec including acute and chronic eosinophilic leukemia Treatment(CEL) who ofhave adult the patients FIP1L1-PDGFRα with 25.08.2005 19.10.2006 Treatment of Philadelphia-positive acute lymphoblastic relapsed or refractory Philadelphia imatinib mesylate Gleevec leukemia Treatmentchromosome of adultpositive patients acute with 11.10.2005 19.10.2006 unresectable, recurrent and/or metastatic dermatofibrosarcoma imatinib mesylate Gleevec Treatment of dermatofibrosarcoma protuberans protuberans (DFSP) 19.12.2005 19.10.2006 Prevention of bleeding in surgical Coagulation factor VIIa Prevention of bleeding episodes in patients with interventions or invasive procedures (recombinant) NovoSeven acquired inhibitors to Factor VIII or Factor IX Treatmentin patients ofwith bleeding acquired episodes hemophilia in 21.07.2004 13.10.2006 surgical interventions or invasive Coagulation Factor VIIa Treatment of bleeding episodes in patients with procedures in patients with acquired (Recombinant) NovoSeven acquired inhibitors to Factor VIII or Factor IX Treatmenthemophilia of cutaneous 16.07.2004 13.10.2006 manifestations in patients with cutaneous T-cell lymphoma (CTCL) vorinostat Zolinza Treatment of T-cell non-Hodgkin's lymphoma Usewho ashave a replacement progressive, solutionpersistant in or 16.03.2004 06.10.2006 Use in the management of patients undergoing Continuous Renal Replacement continuous renal replacement therapy with Therapy (CRRT) to replace water and biocarbonate infusate Normocarb HF hemofiltration Indicatedto correct forelectrolytes patients withand Hunteracid-base 09.08.2005 26.07.2006 syndrome (mucopolysaccharidosis II, Long term enzyme replacement therapy for patients MPS II). Idursulfase has been shown idursulfase Elaprase with mucopolysaccharidosis II (Hunter Syndrome) Forto improve use in combinationwalking capacity with in these 28.11.2001 24.07.2006 dexamethasone for the treatment of multiple myeloma patients who have lenalidomide Revlimid Treatment for multiple myeloma received at least one prior therapy. 20.09.2001 29.06.2006 Treatment of adults with Philadelphia chromosome-positive acute Treatment of Philadelphia-positive acute lymphoblastic lymphoblastic leukemia with Dasatinib Sprycel leukemia Treatmentresistance ofor adultsintolerance with chronicto prior 18.11.2005 28.06.2006 myeloid leukemia with resistance or intolerance to prior therapy including Dasatinib Sprycel Treatment of chronic myelogenous leukemia imatinib 28.11.2005 28.06.2006

Treatment of patients with newly Thalidomide Thalomid Treatment of multiple myeloma Fordiagnosed reducing multiple signs andmyeloma symptoms and 14.10.1998 25.05.2006 inducing and maintaining clinical Treatment of pediatric (0 to 16 years of age) Crohn's remission in pediatric patients with Infliximab REMICADE Disease formoderately treatment to of severely patients active with Crohn's 12.11.2003 19.05.2006 myelodysplastic syndromes (MDS) including previously treated and Decitabine Dacogen Treatment of myelodysplastic syndromes. Foruntreated, use in patientsde novo withand Pompesecondary 08.03.1999 02.05.2006 disease (GAA deficiency). Recombinant human acid alpha- Alglucosidase alfa has been shown to glucosidase Myozyme Treatment of glycogen storage disease type II. Forimprove closure ventilator-free of a clinically survival significant in 19.08.1997 28.04.2006 patent ductus arteriosus in premature infants weighing between 500 and Ibuprofen lysine NeoProfen Treatment of patent ductus arteriosus. 1500 g, who are no more than 32 29.10.1996 13.04.2006 Prophylaxis of organ rejection in Prophylaxis of organ rejection in patients receiving patients receiving allogenic heart Tacrolimus Prograf heart transplants. Fortransplants. use in combination with radiation 06.06.2005 29.03.2006 Treatment of squamous cell cancer of the head and therapy, for the treatment of locally or neck in patients who express epidermal growth factor regionally advanced squamous cell Cetuximab Erbitux receptor. Treatmentcarcinoma of patientsthe head with and transfusion neck 03.07.2000 01.03.2006 dependant anemia due to low or intermediate-1 risk myelodysplastic lenalidomide Revlimid Treatment of myelodysplastic syndromes syndromes associated with a deletion 29.01.2004 27.12.2005

Treatment of patients with advanced Sorafenib Nexavar Treatment of renal cell carcinoma. Treatmentrenal cell carcinoma of growth failure in children 08.10.2004 20.12.2005 with severe primary IGF-1 deficiency Treatment of growth hormone insensitivity syndrome (Primary IGFD) or with growth mecasermin rinfabate iPLEX (GHIS) hormone (GH) gene deletion who 17.05.2002 12.12.2005

Treatment of excessive daytime oxybate Xyrem Treatment of narcolepsy Treatmentsleepiness ofin chronicpatients iron with overload narcolepsy 07.11.1994 18.11.2005 due to blood transfusions Treatment of chronic iron overload in patients with (transfusional hemosiderosis) in Deferasirox Exjade transfusion-dependent anemias Treatmentpatients 2 yearsof patients of age with or olderT-cell acute 21.11.2002 02.11.2005 Treatment of acute lymphoblastic leukemia and lymphoblastic leukemia and T-cell nelarabine Arranon lymphoblastic lymphoma lymphoblastic lymphoma whose 10.08.2004 28.10.2005 Long-term treatment of growth failure in children with severe primary IGF-1 Mecasermin Increlex Treatment of growth hormone insensitivity syndrome. Preventiondeficiency (Primary of bleeding IGFD) in surgical or with 12.12.1995 30.08.2005 interventions or invasive procedures Coagulation factor VIIa Prevention of bleeding episodes in patients with in hemophilia A or B patients with (recombinant) NovoSeven hemophilia A or B, with or without inhibitors inhibitors to Factor VIII or Factor IX 18.06.2004 12.08.2005

Treatment of uncomplicated quinine Sulfate Treatment of malaria ForPlasmodium relief of the falciparum signs and malaria symptoms 03.06.2004 12.08.2005 of pauciarticular or polyarticular course Juvenile Rheumatoid Arthritis meloxicam Mobic TreatmentPrevention ofof juvenilebleeding rheumatoid episodes in arthritis patients with Preventionin patients 2of years bleeding of age in surgicalor older 22.11.2002 11.08.2005 congenital Factor VII interventions or invasive procedures Coagulation factor VIIa deficiency in patients with congenital F VII (recombinant) NovoSeven deficiency 10.09.2004 11.07.2005 Coagulation factor VIIa Treatment of bleeding episodes in patients with Treatment of bleeding episodes in (recombinant) NovoSeven congenital factor VII deficiency Forpatients patients with withFactor VII Deficiency 10.09.2004 11.07.2005 mucopolysaccharidosis VI. N-acetylgalactosamine-4- Treatment of mucopolysaccharidosis Type VI Galsulfase has been shown to sulfatase, recombinant human Naglazyme (Maroteaux-Lamy syndrome). improve walking and stair-climbing 17.02.1999 31.05.2005 Treatment of chronic non-infectious Treatment uveitis involving the posterior segment of the uveitis affecting the posterior segment Fluocinolone Retisert eye. of the eye 31.07.2000 08.04.2005 Treatment of multiple myeloma patients who have received at least Bortezomib Velcade Treatment of multiple myeloma Treatmentone prior therapy of adult patients with newly 15.01.2003 25.03.2005 diagnosed glioblastoma multiforme temozolomide Temodar Treatment of malignant glioma Treatmentconcomitatly and with modification radiotherapy of and 05.10.1998 15.03.2005 aberrant infections induced by Vaccinia Immune Globulin Treatment of severe complications from the smallpox vaccinia virus that include its (Human) Intravenous vaccine Adjunctiveaccidental implantationtherapy in the in treatmenteyes of 18.06.2004 18.02.2005 Treatment of acute hyperammonemia and associated acute hyperammonemia and encephalopathy in patients with deficiencies in enzymes associated encephalopathy in patients benzoate/phenylacetate Ammonul of the urea cycle. Treatmentwith deficiencies of pulmonary in enzymes arterial of the 22.11.1993 17.02.2005 hypertension (WHO Group I) in patients with NYHA Class III or IV Iloprost inhalation solution Ventavis Treatment of pulmonary arterial hypertension Treatmentsymptoms of pediatric patients 1 to 21 17.08.2004 29.12.2004 years old with relapsed or refractory clofarabine Clolar Treatment of acute lymphoblastic leukemia acute lymphoblastic leukemia after at 07.02.2002 28.12.2004 Recombinant human luteinizing stimulating hormone for the treatment of women with concomitantly administered with Gonal- hormone Luveris complicationschronic anovulation due to hypogonadotropic Preventionf (follitropin ofalfa vitamin for injection), deficiency is and 07.10.1994 08.10.2004 in people receiving home parenteral nutrition and thrombormbolic complications in multi-vitiam infusion without warfarin-type anticoagulant therapy people receiving home parenteral vitamin K M.V.I.-12 nutrition who also receive warfarin- 08.03.2004 09.09.2004 Treatment of patients with known or suspected internal Diethylenetriaminepentaacetic contamination with plutonium, americium, or curium to Treatment of internal contamination acid (DTPA) Forincrease use with the humanrates of growth elimination. hormone in the treatment of Treatmentwith plutonium, of short americium bowel syndrome or curium in 28.04.2004 11.08.2004 short bowel syndrome (nutrient malabsorption from the patients receiving specialized gastrointestinal tract resulting from an inadequate nutritional support when used in Glutamine NutreStore absorptive surface). Treatmentconjunction of with patients a rercombinant with the 06.03.1995 10.06.2004 following myelodysplastic syndrome subtypes: refractory anemia or azacitidine Vidaza Treatament of myelodysplastic syndromes Treatmentrefractory anemia of giardiasis with ringed caused by G. 03.12.2001 19.05.2004 duodenalis (also termed G. lamblia) in both adults and pediatric patients tinidazole Tindamax Treatment of giardiasis Treatmentolder than threeof intestinal years ofamebiasis age and 18.04.2002 17.05.2004 amebic liver abcess caused by E. histolytica in both adults and pediatric Tinidazole Tindamax Treatment of amebiasis Forpatients the acute, older thanintermittent three years treatment of age. of 20.08.2003 17.05.2004 hypomobility, "off" episodes ("end-of- Treatment of the on-off fluctuations associated with late- dose-wearing-off" and unpredictable Apomorphine HCl Apokyn stage Parkinson's disease. :on/off" episodes) associated with 22.04.1993 20.04.2004

Treatment of hypercalcemia in patients with parathyroid Treatment of hypercalcemia in cinacalcet Sensipar carcinoma Treatmentpatients with of parathyroidpatients with carcinoma malignant 12.05.2003 08.03.2004 pleural mesothelioma whose disease is either unresectable or who are pemetrexed disodium Alimta Treatment of malignant pleural mesothelioma Forotherwise the use not of candidatesAcetadote(registered for curative 28.08.2001 04.02.2004 TM) Injection, administered intravenously within 8 to 10 hours For the intravenous treatment of moderate to severe after ingestion of a potentially acetylcysteine Acetadote acetaminophen overdose heptotoxic quantity of acetaminophen, 19.10.2001 23.01.2004 Treatment of short bowel syndrome in For use alone or in combination with glutamine in the patients receiving specialized Somatropin (r-DNA) Zorbtive treatment of short bowel syndrome. Indicatednutritional forsupport treatment of infant 06.03.1995 01.12.2003 botulism caused by type A or type B Clostridium botulinum. Botulism immune globulin BabyBIG Treatment of infant botulism. Treatment of patients with known or 31.01.1989 23.10.2003 Treatment of patients with known or suspected internal suspected internal contamination with contamination with radioactive or non-radioactive radioactive cesium and/or radioactive iron(III)-hexacyanoferrate(II) Radiogardase cesium or thallium Foror non-radioactive the ablation of thallium high-grade to increase 01.05.2003 02.10.2003 For the ablation of High-Grade Dysplasia in Barrett's dysplasia in Barrett's esophagus Esophagus in patients who are not considered to be patients who do not undergo porfimer Photofrin candidates for esophagectomy Treatmentesophagectomy of mild to moderate Type I 19.10.2001 01.08.2003 Gaucher disease in adults for whom enzyme replacement therapy is not a miglustat Zavesca Treatment of Gaucher disease. therapeutic option (e.g., due to 29.05.1998 31.07.2003 Treatment of chronic hepatitis C among previously untreated pediatric ribavirin REBETOL Treatment of chronic hepatitis C in pediatric patients Treatmentpatients at ofleast patients three withyears CD20 of age or 04.04.2003 29.07.2003 positive, follicular, non-Hodgkin's Tositumomab and iodine I 131 lymphoma, with and without tositumomab Bexxar Treatment of non-Hodgkin's B-cell lymphoma. Treatmenttransformation, of multiple whose myeloma disease is 16.05.1994 27.06.2003 patients who have received at least two prior therapies and have bortezomib Velcade Treatment of multiple myeloma Treatmentdemonstrated for patientsdisease withprogression Hurler and on 15.01.2003 13.05.2003 Hurler-Scheie forms of Mucopolysaccharidosis I (MPS I) and laronidase Aldurazyme Treatment of patients with mucopolysaccharidosis-I. Forfor patients use in patients with the with Scheie Fabry form disease who 24.09.1997 30.04.2003 to reduce globotriaosylceramide (GL- Ceramide trihexosidase/alpha- 3) deposition in capillary endothelium galactosidase A Fabrazyme Treatment of Fabry's disease. Treatmentof the kidney of acromegalyand certain otherin patients cell 19.01.1988 24.04.2003 who have had an inadequate response to surgery and/or radiation Pegvisomant Somavert Treatment of acromegaly. therapy and/or other medical 24.06.1997 25.03.2003 Expanding the indication to include patients with malignant glioma polifeprosan 20 with carmustine Gliadel Treatment of malignant glioma Forundergoing use as aprimary single dailysurgical exchange resection. for 13.12.1989 25.02.2003 the long (8-16 hour) dwell during Icodextrin 7.5% with Electrolytes Treatment of those patients having end stage renal continuous ambulatory peritoneal Peritoneal Dialysis Solution Extraneal (with 7.5% Icdisease and requiring peritoneal dialysis treatment. dialysis (CAPD) or automated 18.07.1997 20.12.2002 Treatment of diarrhea caused by Cryptosporidium parvum and Giardia nitazoxanide Alinia Treatment of intestinal giardiasis lamblia 14.02.2002 22.11.2002 Treatment of diarrhea caused by Cryptosporidium parvum and Giardia Nitazoxanide Alinia Treatment of cryptosporidiosis. Forlamblia use in secretin stimulation testing 12.12.1996 22.11.2002 for: Stimulation of pancreatic secretions to facilitate the Synthetic porcine secretin For use in the evaluation of exocrine pancreas function. identification of the ampulla of Vater 18.06.1999 01.11.2002 Treatment of opioid dependence in Buprenorphine hydrochloride Subutex Treatment of opiate addiction in opiate users. patients 16 years of age or older 15.06.1994 08.10.2002

Buprenorphine in combination with Treatment of opioid dependence in naloxone Suboxone Treatment of opiate addiction in opiate users. patients 16 years of age or older 27.10.1994 08.10.2002

Treatment of cataplexy associated oxybate Xyrem Treatment of narcolepsy. Initialwith narcolepsy. management of plasma uric acid 07.11.1994 17.07.2002 levels in pediatric patients with Treatment of malignancy-associated or chemotherapy- leukemia,lymphoma, and solid tumor rasburicase Elitek induced hyperuricemia. malignancies who are receiving anti- 11.10.2000 12.07.2002 Treatment of pulmonary arterial treprostinil Remodulin Treatment of pulmonary arterial hypertension. hypertension. 04.06.1997 21.05.2002 Use in secretin stimulation testing for For use in conjunction with diagnostic procedures for stimulation of pancreatic secretions, pancreatic disorders to increase pancreatic fluid including bicarbonate, to aid in the Synthetic porcine secretin secretion. diagnosis of pancreatic exocrine 07.03.2000 04.04.2002 Use in secretin stimulation testing for For use in the diagnosis of gastrinoma associated with stimulation of gastrin secretion to aid Synthetic porcine secretin Zollinger-Ellison syndrome. Treatmentin the diagnosis of patients of gastrinoma with relapsed or 18.06.1999 04.04.2002 refractory low-grade, follicular, or transformed B-cell non-Hodgkin?s ibritumomab tiuxetan Zevalin Treatment of B-cell non-Hodgkin's lymphoma. Treatmentlymphoma, of including patients patients with Kit with(CD117) 06.09.1994 19.02.2002 positive unresectable and/or metastatic malignant gastrointestinal imatinib mesylate Gleevec Treatment of gastrointestinal stromal tumors Adjunctivestromal tumors therapy (GIST) to dietary 01.11.2001 01.02.2002 restriction of tyrosine and phenylalanine in the treatment of Nitisinone Orfadin Treatment of tyrosinemia type 1. hereditary tyrosinemia type 1 16.05.1995 18.01.2002

Treatment of pulmonary arterial Bosentan Tracleer Treatment of pulmonary arterial hypertension. hypertension. 06.10.2000 20.11.2001 years and older with siezures Topiramate Topamax Treatment of Lennox-Gastaut syndrome. associated with Lennox-Gastaut 25.11.1992 28.08.2001

Treatment of hypercalcemia of Zoledronate Zometa, Zabel Treatment of tumor induced hypercalcemia. Formalignancy. long-term treatment of growth 18.08.2000 20.08.2001 failure in children born small for Treatment of growth failure in children who were born gestational age who fail to manifest somatropin [rDNA] Genotropin small for gestational age. Treatmentcatch-up growth of patients by two with years chronic of age. 27.12.2000 25.07.2001 myeloid leukemia (CML) in blast crisis, Imatinib Gleevec Treatment of chronic myelogenous leukemia accelerated phase, or in chronic 31.01.2001 10.05.2001 The treatment of patients with B-cell chronic lymphocytic leukemia who have been treated with alkylating alemtuzumab Campath Treatment of chronic lymphocytic leukemia. Treatmentagents and of who cervical have dystoniafailed in 20.10.1997 07.05.2001 adults to decrease the severity of abnormal head position and neck pain Botulinum toxin type A Botox Treatment of cervical dystonia. Treatmentassociated ofwith patients cervical with dystonia. cervical 20.08.1986 21.12.2000 dystonia to reduce the severity of abnormal head position and neck pain Botulinum toxin type B Myobloc Treatment of cervical dystonia. associated with cervical dystonia. 16.01.1992 08.12.2000 Use for suspected or confirmed methanol poisoning, either alone or in Fomepizole Antizole Treatment of methanol or ethylene glycol poisoning. Reducingcombination neurologic with hemodialysis disability and/or 22.12.1988 08.12.2000 the frequency of clinical relapses in patients with secondary (chronic) Mitoxantrone Novantrone Treatment of secondary-progressive multiple sclerosis. Reducingprogressive, neurologic progressive disability relapsing, and/or or 13.08.1999 13.10.2000 the frequency of clinical relapses in patients with secondary (chronic) Mitoxantrone Novantrone Treatment of progressive-relapsing multiple sclerosis. progressive, progressive relapsing, or 13.08.1999 13.10.2000

Antivenin, crotalidae polyvalent Treatment of envenomations inflicted by North Carol Clark-Evans direct line (615) immune Fab (ovine) CroFab American crotalid snakes. For963-4510 induction of remission and 12.01.1994 02.10.2000 consolidation in patients with acute promyelocytic leukemia (APL) who are Arsenic trioxide Trisenox Treatment of acute promyelocytic leukemia. refractory to, or have relapsed from, 03.03.1998 25.09.2000 Long-term treatment of pediatric Treatment of short stature in patients with Prader-Willi patients who have growth failure due Somatropin [rDNA] Genotropin Forsyndrome. the initiation and re-initiation of spermatogenesis in Forto Prader-Willi the induction syndrome of spermatogenesis (PWS). 06.07.1999 20.06.2000 adult males with reproductive failure due to in men with primary and secondary hypothalamic or pituitary dysfunction, hypogonadotropic hypogonadotropic hypogonadism in Follitropin alfa, recombinant Gonal-F hypogonadism. AMENDED indication 6/27/00: For the Treatmentwhom the causeof patients of infertility with CD33 is not due 21.12.1998 24.05.2000 positive acute myeloid leukemia in first relapse who are 60 years of age Gemtuzumab zogamicin Mylotarg Treatment of CD33-positive acute myeloid leukemia. Foror older the long-termand who areintravenous not considered 24.11.1999 17.05.2000 treatment of pulmonary hypertension Treatment of secondary pulmonary hypertension due to associated with the scleroderma Epoprostenol Flolan intrinsic precapillary pulmonary vascular disease. spectrum of disease in New York 22.03.1999 14.04.2000 Delaying time to disease progression Delaying time to disease progression in patients with in patients with severe, malignant Interferon gamma-1b Actimmune severe, malignant osteopetrosis. Treatmentosteopetrosis. of cutaneous 30.09.1996 10.02.2000 manifestations of cutaneous T-cell lymphoma in patients who are Bexarotene Targretin Treatment of cutaneous T-cell lymphoma. Inrefractory conjunction to at withleast ventilatory one prior support 18.06.1999 29.12.1999 and other appropriate agents, in the Treatment of persistent pulmonary hypertension in the treatment of term and near-term (>34 Nitric oxide INOmax newborn. Preventionweeks) neonates and treatment with hypoxic of carnitine 22.06.1993 23.12.1999 Treatment of manifestations of carnitine deficiency in deficiency in patients with end stage patients with end stage renal disease who require renal disease who are undergoing Levocarnitine Carnitor dialysis. dialysis. 06.09.1988 15.12.1999 Treatment of advanced breast cancer Treatment of advanced breast cancer in in postmenopausal women whose postmenopausal women whose disease has disease has progressed following Exemestane Aromasin progressed following tamoxifen therapy. tamoxifen therapy. 19.09.1991 21.10.1999 Short term treatment of apnea of prematurity in infants between 28 and Caffeine Cafcit Treatment of apnea of prematurity. Componentless than 33 ofweeks adjuvant gestational therapy age. in 20.09.1988 21.09.1999 patients with evidence of axillary node tumor involvement following resection Epirubicin Ellence Treatment of breast cancer. Treatmentof primary breastof adult cancer. patients with 14.09.1999 15.09.1999 refractory anaplastic astrocytoma, i.e., patients at first relapse who have Temozolomide Temodar Treatment of recurrent malignant glioma. Treatmentexperienced of diseasemetastatic progression carcinoma on of a 05.10.1998 11.08.1999 the ovary in patients with disease that is refractory to both paclitaxel- and Doxorubicin liposome Doxil Treatment of ovarian cancer. platinium-based chemotherapy 04.11.1998 28.06.1999 Reduction of the incidence of Reduction of the incidence of moderate to severe moderate to severe xerostomia in xerostomia in patients undergoing post-operative patients undergoing post-operative Amifostine Ethyol radiation treatment for head and neck cancer. radiation treatment for head and neck 12.05.1998 24.06.1999 Reduction in signs and symptoms of moderately to Reduction in signs and symptoms of severely active polyarticular-course juvenile rheumatoid moderately to severely active arthritis in patients who have had an inadequate polyarticular-course juvenile etanercept Enbrel response to one or more disease-modifying anti- (1)rheumatoid In adult patientsarthritis infor patients treatment who and 27.10.1998 27.05.1999 Antihemophilic factor/von prevention of bleeding in hemophilia A Willebrand factor complex Treatment of patients with von Willebrand's disease (classic hemophilia) and (2) in adult (human), dried, pasteurized Humate-P and pediatric patients for treatment of 16.10.1992 01.04.1999

Intrathecal treatment of lymphomatous Cytarabine liposomal DepoCyt Treatment of neoplastic meningitis. Treatmentmeningitis. of bleeding episodes in 02.06.1993 01.04.1999 Coagulation factor VIIa Treatment of bleeding episodes in hemophilia A or B hemophilia A or B patients with (recombinant) NovoSeven patients with inhibitors to Factor VIII or Factor IX. inhibitors to Factor VIII or Factor IX. 06.06.1988 25.03.1999

For relief of allodynia (painful hypersensitivity), and Lidocaine patch 5% Lidoderm Patch chronic pain in postherpetic neuralgia. Treatment of patients with persistent 24.10.1995 19.03.1999 or recurrent cutaneous T-cell lymphoma whose malignant cells denileukin diftitox Ontak Treatment of patients with cutaneous T-cell lymphoma Forexpress use inthe combination CD25 component with of the 21.08.1996 05.02.1999 cyclophosphamide as a conditioning As preparative therapy in the treatment of malignancies regimen prior to allogeneic Busulfan Busulfex with bone marrow transplantation. hematopoietic progenitor cell 28.07.1994 04.02.1999 Topical treatment of cutaneous lesions in patients with AIDS-related Alitretinoin Panretin TreatmentPrevention ofof AIDS-relatedPneumocystis Kaposi's carinii pneumonia sarcoma. (PCP) in Kaposi's sarcoma. 24.03.1998 02.02.1999 high-risk, HIV-infected patients defined by a history of Prevention of PCP in patients who are one or more episodes of PCP and/or a peripheral CD4+ intolerant to trimethoprim- Atovaquone Mepron (T4 helper/inducer) lymphocyte count less than or equal sulfamethoxazole. 14.08.1991 05.01.1999 Improve wakefulness in patients with Treatment of excessive daytime sleepiness in excessive daytime sleepiness Modafinil Provigil narcolepsy. associated with narcolepsy. 15.03.1993 24.12.1998 #1) Attenuation of primary CMV disease associated with kidney transplant recipients who are seronegative for CMV and who receive a kidney from a CMV seropositve donor; #2) Prophylaxis of Prevention or attenuation of primary cytomegalovirus CMV disease associated Cytomegalovirus immune globulin disease in immunosuppressed recipients of organ transplantation of kidney (all other), (human) CytoGam transplants. Aslung, an adjunctive diagnostic tool for 03.08.1987 04.12.1998 serum thyroglobulin (Tg) testing with or without radioiodine imaging in the Thyrotropin alpha Thyrogen As an adjunct in the diagnosis of thyroid cancer. follow-up of patients with thyroid 24.02.1992 30.11.1998 Supression of severe diarrhea and Treatment of severe diarrhea and flushing associated flushing associated with malignant Octreotide Sandostatin LAR with malignant carcinoid tumors. carcinoid syndrome. 24.08.1998 25.11.1998

Reduction of growth hormone and IGF- Octreotide Sandostatin LAR Treatment of acromegaly. 1 (somatomedin C) in acromegaly. 24.08.1998 25.11.1998 Treatment of diarrhea associated with vasoactive Treatment of profuse watery diarrhea Octreotide Sandostatin LAR intestinal peptide tumors (VIPoma). Forassociated intravesical with therapyVIPoma. of BCG- 24.08.1998 25.11.1998 refractory carcinoma in situ of the Valrubicin Valstar Treatment of carcinomamoderately in to situ severely of the activeurinary Crohn's bladder. Treatmenturinary bladder of moderately in patients to for severely whom 23.05.1994 25.09.1998 disease for the reduction of the signs and symptoms, in active Crohn's disease for the patients who have an inadequate response to reduction of the signs and symptoms, Infliximab Remicade conventional therapy; and treatment of patients with Adjunctivein patients whotreatment have anof Lennox-inadequate 14.11.1995 24.08.1998 Gastaut syndrome in pediatric and Lamotrigine Lamictal Treatment of Lennox-Gastaut syndrome. Acuteadult patients. treatment of the cutaneous 23.08.1995 24.08.1998 manifestations of moderate to severe erythema nodosum leprosum (ENL) Thalidomide Thalomid Treatment of erythema nodosum leprosum. and as maintenance therapy for 26.07.1995 16.07.1998

Rifapentine Priftin Treatment of pulmonary tuberculosis. 09.06.1995 22.06.1998

For use as an adjunctive topical antimicrobial agent to control bacterial infection when used under moist dressings over meshed autografts on excised burn Mafenide acetate solution Sulfamylon solution wounds. Prophylaxis of acute organ rejection in 18.07.1990 05.06.1998 patients receiving renal Prophylaxis of solid organ rejection. transplantation when used as part of Basiliximab Simulect Oralan immunosuppressive replacement therapy regimen of the that 12.12.1997 12.05.1998 genetically determined sucrase deficiency, which is part of congenital Sacrosidase Sucraid Treatment of congenital sucrase-isomaltase deficiency. sucrease-isomaltase deficiency. 10.12.1993 09.04.1998 Reduction in the duration of neutropenia, fever, Reducing the time to neutrophil antibiotic use, and hospitalization, following induction recovery and the duration of fever, and consolidation treatment for acute myeloid following induction or consolidation Filgrastim Neupogen leukemia. Forchemotherapy anticoagulation treatment in patients of adults with with 07.11.1996 02.04.1998 heparin-induced thrombocytopenia Treatment of heparin-associated thrombocytopenia and associated thromboembolic Lepirudin Refluden type II. Todisease reduce in theorder frequency to prevent of furtherpainful 13.02.1997 06.03.1998 crises and to reduce the need for Treatment of patients with sickle cell anemia as shown blood transfusions in adult patients Hydroxyurea Droxia by the presence of hemoglobin S. with sickle cell anemia with recurrent 01.10.1990 25.02.1998

Treatment of xerostomia and keratoconjunctivitis sicca Treatment of dry mouth in patients Pilocarpine HCl Salagen in Sjogren's syndrome patients. with Sjogren's syndrome. 28.02.1992 11.02.1998 Treatment of adults with metastatic Aldesleukin Proleukin Treatment of metastatic melanoma. melanoma. 10.09.1996 09.01.1998 Prevention of recurrence of malignant pleural effusions in symptomatic Sterile talc powder Sclerosol Intrapleural ATreatment of malignant pleural effusion. patients. 18.09.1995 24.12.1997 Treatment of bronchopulmonary infections of Management of cystic fibrosis patients Tobramycin for inhalation TOBI Pseudomonas aeruginosa in cystic fibrosis patients. with P.aeruginosa. 13.10.1994 22.12.1997

As replacement therapy for growth hormone deficiency Somatropin for injection Nutropin in adults after epiphyseal closure. Prophylaxis of acute organ rejection in 18.11.1996 15.12.1997 patients receiving renal transplants, to be used as a part of an Daclizumab Zenapax Prevention of acute renal allograft rejection. immunosuppressive regimen that 05.03.1993 10.12.1997

Ursodiol URSO Treatment of patients with primary biliary cirrhosis. 20.06.1991 10.12.1997 As an antidote to ethylene glycol (antifreeze) poisoning, or for use in Fomepizole Antizole Treatment of methanol or ethylene glycol poisoning. suspected ethylene glycol ingestion. 22.12.1988 04.12.1997 rituximab Rituxan Treatment of non-Hodgkin's B-cell lymphoma. 13.06.1994 26.11.1997

Prevention of severe chemotherapy-induced Oprelvekin Neumega thrombocytopenia. 17.12.1996 25.11.1997

Somatropin Genotropin Treatment of adults with growth hormone deficiency. 06.09.1994 31.10.1997

Treatment of idiopathic or organic growth hormone Sermorelin acetate Geref deficiency in children with growth failure. 14.09.1988 26.09.1997 Liposomal amphotericin B AmBisome Treatment of visceral leishmaniasis. Treatment of visceral leishmaniasis. 06.12.1996 11.08.1997 Treatment of disseminated Liposomal amphotericin B AmBisome Treatment of cryptococcal meningitis. cryptococcosis including meningitis. 10.12.1996 11.08.1997

For the second line treatment of AIDS- Paclitaxel Taxol TreatmentFor the management of AIDS-related of selected, Kaposi's refractory, sarcoma. patients related Kaposi's sarcoma. 25.03.1997 04.08.1997 with epilepsy, on stable regimens of antiepileptic drugs Diazepam viscous solution for (AEDs), who require intermittent use of diazepam to rectal administration control bouts of increased seizure activity. Treatment of metastatic breast cancer 25.02.1992 29.07.1997 Hormonal therapy of metastatic carcinoma of the in postmenopausal women with Toremifene Fareston breast. Treatmentestrogen positive of patients or receptor with essential unknown 19.09.1991 29.05.1997 thrombocythemia to reduce the elevated platelet count and the risk of Anagrelide Agrylin Treatment of essential thrombocythemia. Forthrombosis the control and and to ameliorate prevention of 27.01.1988 14.03.1997 hemorrhagic episodes in patients with Coagulation Factor IX hemophilia B (congenital factor IX (recombinant) BeneFix Treatment of hemophilia B. deficiency and Christmas disease), 03.10.1994 11.02.1997 For maintenance treatment of patients with Wilson's disease who have been Zinc acetate Galzin Treatment of Wilson's disease. initially treated with a chelating agent. 06.11.1985 28.01.1997 Treatment of short stature associated Treatment of short stature associated with Turner with Turner syndrome in patients Somatropin Humatrope syndrome. whose epiphyses are not closed. 08.05.1990 30.12.1996 Treatment of short stature associated with Turner's Treatment of growth failure associated Somatropin for injection Nutropin syndrome. with Turner syndrome. 23.03.1989 30.12.1996 relapses in patients with relapsing- Glatiramer acetate Copaxone Treatment of multiple sclerosis. Inremitting combination multiple with sclerosis. corticosteroids as 09.11.1987 20.12.1996 initial chemotherapy for the treatment Mitoxantrone Novantrone Treatment of hormone refractory prostate cancer. of patients with pain related to 21.08.1996 13.11.1996 Treatment of homocystinuria to decrease elevated homocysteine Betaine Cystadane Treatment of homocystinuria. Treatmentblood levels. of invasive fungal 16.05.1994 25.10.1996 infections in patients who are Amphotericin B lipid complex Abelcet TreatmentFor continous of invasive epidural fungaladministration infections. as adjunctive Inrefractory combination to or intolerantwith opiates of for the 05.12.1991 18.10.1996 therapy with intraspinal opiates for the treatment of pain treatment of severe pain in cancer Clonidine Duraclon Forin cancer use as patients a diluent tolerant in the to,intrathecal or unresponsive administration to, of Forpatients the intrathecal that is not administrationadequately relieved of 24.01.1989 02.10.1996 methotrexate and cytarabine for the prevention or methotrexate and cytarabine for the Buffered intrathecal treatment meningeal leukemia and lymphocytic prevention or treatment of meningeal electrolyte/dextrose injection Elliotts B Solution lymphoma. leukemia and lymphocytic lymphoma. 24.08.1994 27.09.1996

Relief of bladder pain or discomfort Pentosan polysulfate sodium Elmiron Treatment of interstitial cystitis. associated with interstitial cystitis. 07.08.1985 26.09.1996 As an adjunct to surgery to prolong survival in patients with recurrent glioblastoma multiforme for whom polifeprosan 20 with carmustine Gliadel Treatment of malignant glioma. surgical resection is indicated 13.12.1989 23.09.1996

Treatment of patients with symptomatic orthostatic Treatment of symptomatic orthostatic Midodrine HCl Amatine hypotension. hypotension. 05.12.1996 06.09.1996

Treatment of AIDS wasting or Somatropin for injection Serostim Treatment of AIDS-associated catabolism/weight loss. cachexia. 15.11.1991 23.08.1996

For the acute treatment of patients with status For the control of generalized Fosphenytoin Cerebyx Treatmentepilepticus ofof neurocysticercosisthe grand mal type. due to Taenia solium Treatmentconvulsive ofstatus parenchymal epilepticus. 04.06.1991 05.08.1996 as: 1) chemotherapy of parenchymal, subarachnoidal neurocysticercosis due to active and racemose (cysts in spinal fluid) neurocysticercosis lesions caused by larval forms of the Albendazole Albenza in symptomatic cases and 2) prophylaxis of epilepsy Treatmentpork tapeworm, of cystic Taenia hydatid solium. disease of 18.01.1996 11.06.1996 Treatment of hydatid disease (cystic echinococcosis the liver, lung, and peritoneum, due to E. granulosus larvae or alveolar echinococcosis caused by the larval form of the dog Albendazole Albenza due to E. multilocularis larvae). Totapeworm, differentiate Echinococcus between pituitary granulosus. and 17.01.1996 11.06.1996 For use in differentiating pituitary and ectopic ectopic production of ACTH in patients production of ACTH in patients with ACTH-dependent with ACTH-dependent Cushing's Corticorelin ovine triflutate Acthrel Cushings syndrome. syndrome. 24.11.1989 23.05.1996

Ofloxacin Ocuflox Ophthalmic SoManagementTreatment of bacterialof patients corneal with leukemia, ulcers. lymphoma, and TreatmentManagement of bacterialof patients corneal with ulcers. 18.04.1991 22.05.1996 solid tumor malignancies who are receiving cancer leukemia, lymphoma, and solid tumor therapy which causes elevations of serum and urinary malignancies who are receiving Allopurinol sodium Aloprim for Injection uric acid levels and who cannot tolerate oral therapy. Treatmentcancer therapy of relapsing which causes forms of 16.10.1992 17.05.1996 multiple sclerosis to slow the accumulation of physical disability and Interferon beta-1a Avonex Treatment of multipleurea cycle sclerosis. disorders: carbamylphosphate Adjunctivedecrease the therapy frequency in the of chronic clinical 16.12.1991 17.05.1996 synthetase deficiency, ornithine transcarbamylase managment of patients with urea cycle deficiency, and arginiosuccinic acid synthetase disorders involving deficiencies of sodium phenylbutyrate Buphenyl deficiency. carbamylphosphate synthetase, 22.11.1993 30.04.1996 First line cytotoxic therapy for Daunorubicin citrate liposome Treatment of patients with advanced HIV-associated advanced, HIV related Kaposi's injection DaunoXome Kaposi's sarcoma. sarcoma. 14.05.1993 08.04.1996 Treatment of CMV retinitis in patients with acquired immunodeficiency Ganciclovir intravitreal implant Vitrasert Implant Treatment of cytomegalovirus retinitis. syndrome. 07.06.1995 04.03.1996

Treatment of malignant pleural Bleomycin sulfate Blenoxane Treatment of malignant pleural effusion. effusion. 17.09.1993 20.02.1996 For the prevention of serious lower Prophylaxis of respiratory syncytial virus lower respiratory tract infections caused by Respiratory syncytial virus respiratory tract infections in infants and young children RSV in children less than 24 months immune globulin (Human) Respigam Forat high use risk in the of RSVmobilization disease. of peripheral blood Forof age use with in the bronchopulmonary mobilization of 27.09.1990 18.01.1996 progenitor cells for collection in patients who will hematopoietic progenitor cells into the receive myeloablative or myelosuppressive peripheral blood collection by Filgrastim Neupogen chemotherapy. Photodynamicleukapheresis. therapy with 17.07.1995 28.12.1995 For the photodynamic therapy of patients with primary PHOTOFRIN for the palliation of or recurrent obstructing (either partially or completely) patients with completely obstructing Porfimer sodium Photofrin esophageal carcinoma. Treatmentesophageal of cancer, patients or with of patients with 06.06.1989 27.12.1995 amyotrophic lateral sclerosis. Riluzole extends survival and/or time to Riluzole Rilutek Treatment of amyotrophic lateral sclerosis. Totracheostomy. reduce the cumulative renal toxicity 16.03.1993 12.12.1995 associated with repeated For use as a chemoprotective agent for cisplatin in the administration of cisplatin in patients Amifostine Ethyol treatment of advanced ovarian carcinoma. Inductionwith advanced of remission ovarian incancer. patients with 30.05.1990 08.12.1995 acute promyelocytic leukemia who are refractory to or unable to tolerate Tretinoin Vesanoid Treatment of acute promyelocytic leukemia. anthracycline based cytotoxic 24.10.1990 22.11.1995

Treatment of chronic myelogenous Interferon alfa-2a Roferon A Treatment of chronic myelogenous leukemia. leukemia. 06.06.1989 19.10.1995 Long-term intravenous treatment of primary pulmonary hypertension in Epoprostenol Flolan Treatment of primary pulmonary hypertension. FollowingNYHA Class induction III and chemotherapyClass IV patients. in 25.09.1985 20.09.1995 To reduce neutropenia and leukopenia and decrease older adult patients with acute the incidence of death due to infection in patients with myelogenous leukemia to shorten Sargramostim Leukine acute myelogenous leukemia. Fortime initiation to neutrophil of treatment recovery and and to 06.03.1995 15.09.1995 For the acute treatment and prophylaxis of life- prophylaxis of frequently recurring threatening ventricular tachycardia or ventricular ventricular fibrillation and Amiodarone HCl Cordarone fibrillation. Cardiomyopathyhemodynamically associated unstable ventricular with 16.03.1994 03.08.1995 doxorubicin administration in women For the prevention of cardiomyopathy associated with with metastatic breast cancer who Dexrazoxane Zinecard doxorubicin administration. have received a cumulative dose of 17.12.1991 26.05.1995 Treatment of adults and children with Rho (D) immune globulin chronic and acute immune intravenous (human) WinRho SD Treatment of immune thrombocytopenic purpura. thrombocytopenic purpura. 09.11.1993 24.03.1995

Treatment of patients with severe chronic neutropenia Treatment of patients with severe Filgrastim Neupogen (absolute neutrophil count less than 500/mm3). chronic neutropenia. 07.11.1990 19.12.1994

Treatment of nephropathic cystinosis Cysteamine Cystagon Treatment of nephropathic cystinosis. in adults and children. 25.01.1991 15.08.1994 For use in combination with pyrimethamine for the treatment of Toxoplasma gondii Toxoplasmosis, as adjunctive with Sulfadiazine encephalitis in patients with and without AIDS. pyrimethamine 14.03.1994 29.07.1994

Aminosalicylic acid Paser Granules Treatment of tuberculosis infections TreatmentReduce the of duration tuberculosis of neutropenia 19.02.1992 30.06.1994 and neutropenia sequelae in patients Treatment of neutropenia associated with bone marrow with non-myeloid malignancies Filgrastim Neupogen transplants. undergoing ablative chemotherapy 01.10.1990 15.06.1994

Short-course treatment of Rifampin, isoniazid, pyrazinamide Rifater For the short-course treatment of tuberculosis. tuberculosis. 12.09.1985 31.05.1994

Replacement therapy in patients with types I, II, and III Enzyme replacement therapy in Imiglucerase Cerezyme Gaucher's disease. Treatmentpatients with of typesymptoms I Gaucher's of xerostomia disease. 05.11.1991 23.05.1994 from salivary gland hypofunction Treatment of xerostomia induced by radiation therapy caused by radiotherapy for cancer of Pilocarpine Salagen for head and neck cancer. Treatmentthe head and of patientsneck. with hemophilia 24.09.1990 22.03.1994 A or von Willebrand's disease (type I) Treatment of mild hemophilia A and von Willebrand's whose factor VIII coagulant activity Desmopressin acetate disease. level is greater than 5%. 22.01.1991 07.03.1994 treatment of patients with acute Pegaspargase Oncaspar Treatment of acute lymphocytic leukemia. Inlymphoblastic conjunction leukemiawith standard who therapiesare 20.10.1989 01.02.1994 in the management of cystic fibrosis To reduce mucous viscosity and enable the clearance patients to reduce the frequency of Dornase alfa Pulmozyme Forof airway prophylactic secretions use into patientsreduce perioperativewith cystic fibrosis. blood loss respiratory infections requiring 16.01.1991 30.12.1993 and the homologous blood transfusion requirement in patients undergoing cardiopulmonary bypass surgery in Aprotinin Trasylol the course of repeat coronary artery bypass graft For prophylaxis of children with clinical 17.11.1993 29.12.1993 or immunologic evidence of human Immune globulin intravenous, Infection prophylaxis in pediatric patients affected with immunodeficiency virus to decrease human Gamimune N the human immunodeficiency virus. Concurrentthe frequency leucovorin of serious administration and minor 18.02.1993 27.12.1993 as an alternative therapy for the Treatment of Pneumocystis carinii pneumonia in AIDS treatment of moderate to severe PCP Trimetrexate glucuronate Neutrexin patients. in immunocompromised patients who 15.05.1986 17.12.1993 Treatment of children with growth Treatment of growth retardation associated with chronic failure associated with chronic renal Somatropin for injection Nutropin renal failure. Treatmentinsufficency. of ocular disorders referred 04.08.1989 17.11.1993 to by the terms vernal keratoconjunctivitis, vernal Lodoxamide tromethamine Alomide Ophthalmic SoTreatment of patientsvernal keratoconjunctivitis. with anorexia, cachexia, or Treatmentconjunctivitis, of anorexia, vernal keratitis. cachexia, or 16.10.1991 23.09.1993 significant weight loss (=/>10% of baseline body weight) an unexplained significant weight loss Megestrol acetate Megace and confirmed diagnosis of AIDS. Asin patients adjunctive with therapy a diagnosis in the of treatment 13.04.1988 10.09.1993 of partial and generalized seizures Felbamate Felbatol Treatment of Lennox-Gastaut syndrome. associated with the Lennox-Gastaut 24.01.1989 29.07.1993 In ambulatory patients with relapsing- remitting multiple sclerosis to reduce the frequency of clinical Interferon beta-1b Betaseron Treatment of multiple sclerosis. exacerbations. 17.11.1988 23.07.1993

Levomethadyl acetate Treatment of heroin addicts suitable for maintenance For the management of opiate hydrochloride Orlaam on opiate agonists. dependence. 24.01.1985 09.07.1993

Treatment of children with central Leuprolide acetate Lupron Injection Treatment of central precocious puberty. precocious puberty. 25.07.1988 16.04.1993

Cladribine Leustatin Injection Treatment of hairy cell leukemia. 15.11.1990 26.02.1993 Prophylaxis and treatment of bleeding in individuals Treatment and prophylaxis of bleeding Antihemophilic factor with hemophilia A or for prophylaxis when surgery is in patients with hemophilia A (not von (recombinant) Kogenate required in individuals with hemophilia A. Willebrand's disease) 25.09.1989 25.02.1993 location of extraphepatic malignant Satumomab pendetide Oncoscint CR/OV DetectionPrevention of of ovarian disseminated carcinoma. Mycobacterium avium Preventiondisease in patients of disseminated with known 25.09.1989 29.12.1992 complex disease in patients with advanced HIV Mycobacterium avium complex Rifabutin Mycobutin infection. disease in patients with advanced HIV 18.12.1989 23.12.1992

For the stimulation of appetite and prevention of weight Treatment of anorexia associated with Dronabinol Marinol loss in patients with a confirmed diagnosis of AIDS. weight loss in patients with AIDS. 15.01.1991 22.12.1992 Treatment of primary systemic carnitine deficiency. (approved 12/27/85) Treatment of primary and secondary carnitine Treatment of secondary carnitine Levocarnitine Carnitor deficiency of genetic origin. Fordeficiency. the acute (approved oral treatment 12/16/92) of mild to 26.07.1984 16.12.1992 moderate Pneumocystis carinii Treatment of AIDS associated Pneumocystis Carinii pneumonia in patients who are Atovaquone Mepron Pneumonia. intolerant to trimethoprim- 10.09.1990 25.11.1992 For the palliative treatment of patients Treatment of patients with multiple myeloma for whom with multiple myeloma for whom oral Melphalan Alkeran For Injection oral therapy is inappropriate. melphalan is not appropriate. 24.02.1992 18.11.1992

Treatment of life-threatening ventricular Sotalol HCl Betapace tachyarrhythmias. 23.09.1988 30.10.1992 Prevention and control of bleeding in Replacement treatment and prophylaxis of the factor IX deficiency, also known as Coagulation factor IX Mononine hemorrhagic complications of hemophilia B. Treatmenthemophilia ofB adultsor Christmas who can disease. tolerate 27.06.1989 20.08.1992 oral medication and who have mild to Treatment of mild to moderate acute malaria caused by moderate malaria caused by Halofantrine Halfan susceptible strains of P. falciparum and P. vivax. Plasmodium falciparum or 04.11.1991 24.07.1992 Induction therapy in patients with refractory childhood acute Treatment of refractory childhood acute lymphocytic lymphoblastic leukemia when used in Teniposide Vumon for injection Treatmentleukemia. of intractable spasticity caused by spinal Managementcombination with of severe other approvedspasticity of 01.11.1984 14.07.1992 cord injury, multiple sclerosis, and other spinal diseases spinal cord origin in patients who are (including spinal ischemia, spinal tumor, transverse unresponsive to oral baclofen therapy Baclofen Lioresal Intrathecal myelitis, cervical spondylosis, and degenerative Combinationor experience therapy intolerable with CNS zidovudine side 10.11.1987 25.06.1992 is indicated for the treatment of adult patients with advanced HIV infection Zalcitabine Hivid Treatment of AIDS. (CD4 count < 300) who have 28.06.1988 19.06.1992

Treatment of adults (>18 years old) Aldesleukin Proleukin Treatment of metastatic renal cell carcinoma. Treatmentwith metastatic of central renal precociouscell carcinoma. 14.09.1988 05.05.1992 puberty (gonadotropin-dependent precocious puberty) in children of both Nafarelin acetate Synarel Nasal SolutionTreatment of central precocious puberty. sexes. 20.07.1988 26.02.1992

Treatment of myxedema Liothyronine sodium injection Triostat Treatment of myxedema coma/precoma. coma/precoma. 30.07.1990 31.12.1991 For replacement therapy in congenital deficiency of AT- III for prevention and treatment of thrombosis and Antithrombin III (human) Thrombate III pulmonary emboli. 26.11.1984 30.12.1991 Treatment of central precocious Histrelin acetate Supprelin Injection Treatment of central precocious puberty. Forpuberty. use in combination with 5- 10.08.1988 24.12.1991 For use in combination with 5-fluorouracil for the fluorouracil to prolong survival in the Leucovorin Leucovorin calcium treatment of metastatic colorectal cancer. Singlepalliative agent treatment treatment of patients for adult with 08.12.1986 12.12.1991 patients with alpha-interferon- Pentostatin for injection Nipent Treatment of hairy cell leukemia. Forrefractory intrathecal hairy orcell epidural leukemia. infusion in 10.09.1987 11.10.1991 the treatment of tractable chronic For use in microinfusion devices for intraspinal pain. It was developed for use in Morphine sulfate concentrate administration in the treatment of intractable chronic continuous microinfusion devices and (preservative free) Infumorph pain. Preventionmay require of dilution RDS (hyaline before usemembrane as 12.07.1990 19.07.1991 disease) in premature infants less than 1250 grams birthweight or with Beractant Survanta intratracheal Preventions of neonatal respiratory distress syndrome. Treatmentevidence of of surfactant ("rescue") deficiency. of premature 05.02.1986 01.07.1991 infants with RDS confirmed by x-ray Beractant Survanta intratracheal Treatments of neonatal respiratory distress syndrome. and requiring mechanical ventilation. 05.02.1986 01.07.1991 Treatment of chronic lymphocytic leukemia (CLL), Fludarabine phosphate Fludara including refractory CLL. Long-term enzyme replacement 18.04.1989 18.04.1991 therapy for children, adolescents and For replacement therapy in patients with Gaucher's adult patients with a confirmed Alglucerase injection Ceredase disease type I. diagnosis of Type I Gaucher disease 11.03.1985 05.04.1991 Treatment of neutropenia associated with bone marrow transplant, for the treatment of graft failure and delay of engraftment, and for the promotion of early Sargramostim Leukine engraftment. 03.05.1990 05.03.1991

Gallium nitrate injection Ganite TreatmentFor use as ofreplacement hypercalcemia therapy of malignancy. in patients with 05.12.1988 17.01.1991 hemophilia B for the prevention and control of bleeding episodes, and during surgery to correct defective Coagulation Factor IX (human) AlphaNine hemostasis. 05.07.1990 31.12.1990 Treatment of anemia associated with HIV infection or Treatment of AZT-induced anemia in Epoetin alfa Epogen HIV treatment. SingleHIV infected agent patients.palliative treatment of 01.07.1991 31.12.1990 patients with persistent or recurrent ovarian cancer following first-line Altretamine Hexalen Treatment of advanced adenocarcinoma of the ovary. therapy with a cisplatin and/or 09.02.1984 26.12.1990

Interferon gamma 1-b Actimmune Treatment of chronic granulomatous disease. 30.09.1988 20.12.1990

Treatment of hyperphosphatemia in end stage renal Calcium acetate Phos-Lo failure. 22.12.1988 10.12.1990

Treatment of Trypanosoma brucei gambiense infection Eflornithine HCl Ornidyl (sleeping sickness). 23.04.1986 28.11.1990 Citric acid, glucono-delta-lactone Treatment of renal and bladder calculi of the apatite or and magnesium carbonate Renacidin Irrigation struvite variety. 28.08.1989 02.10.1990

Treatment of acute myelogenous leukemia, also Idarubicin HCl for injection Idamycin referred to as acute nonlymphocytic leukemia. 25.07.1988 27.09.1990

Colfosceril palmitate, cetyl alcohol, Treatment of established hyaline membrane disease at tyloxapol Exosurf Neonatal for Inall gestational ages. 20.10.1989 02.08.1990 Colfosceril palmitate, cetyl alcohol, as respiratory distress syndrome, in infants born at 32 tyloxapol Exosurf Neonatal for Inweeks gestation or less. 20.10.1989 02.08.1990 Adjunctive diagnostic agent in the For use as a diagnostic adjunct in patients with localization of primary or metastatic Iobenguane Sulfate I 131 pheochromocytoma. pheochromocytomas. 14.11.1984 21.03.1990

For enzyme replacement therapy for ADA deficiency in Pegademase bovine Adagen patients with severe combined immunodeficiency. 29.05.1984 21.03.1990

Treatment of strabismus associated with dystonia in Botulinum toxin type A Botox adults (patients 12 years of age and above). 22.03.1984 29.12.1989 Treatment of blepharospasm associated with dystonia Botulinum toxin type A Botox in adults (patients 12 years of age and above). 22.03.1984 29.12.1989

Cromolyn sodium Gastrocrom TreatmentFor the treatment of mastocytosis. of patients with hereditary 08.03.1984 22.12.1989 antithrombin III deficiency in connection with surgical or obstetrical procedures or when they suffer from Antithrombin III (human) ATnativ Forthromboembolism. induction of ovulation in women with hypothalamic 08.02.1985 13.12.1989 amenorrhea due to a deficiency or absence in the quantity or pulse pattern of endogenous GnRH Gonadorelin acetate Lutrepulse secretion. 22.04.1987 10.10.1989

Treatment of cytomegalovirus retinitis in Ganciclovir sodium Cytovene immunocompromised patients with AIDS. 31.10.1985 23.06.1989

Prevention of Pneumocystis carinii pneumonia in Pentamidine isethionate Nebupent Aspatients an adjuvant at high torisk levodopa of developing and carbidopa this disease. treatment of 12.01.1988 15.06.1989 idiopathic Parkinson's disease (paralysis agitans), postencephalitic Parkinsonism, and symptomatic Selegiline HCl Eldepryl Parkinsonism. 07.11.1984 05.06.1989

Treatment of anemia associated with end stage renal Epoetin alfa Epogen disease. 10.04.1986 01.06.1989

For antituberculosis treatment where use of the oral Rifampin Rifadin I.V. form of the drug is not feasible. 09.12.1985 25.05.1989

Prophylaxis of Plasmodium falciparum malaria which is Mefloquine HCl Lariam resistant to other available drugs. 13.04.1988 02.05.1989 Treatment of acute malaria due to Plasmodium Mefloquine HCl Lariam falciparum and Plasmodium vivax. In combination with certain other 13.04.1988 02.05.1989 approved antineoplastic agents, for third line chemotherapy in the Ifosfamide Ifex Treatment of testicular cancer. treatment of germ cell testicular 20.01.1987 30.12.1988

For use as a prophylactic agent in reducing the Mesna Mesnex incidence of ifosfamide-induced hemorrhagic cystitis. 14.11.1985 30.12.1988

Treatment of patients with esophageal varices that Ethanolamine oleate Ethamolin have recently bled, to prevent rebleeding. 22.03.1984 22.12.1988 Succimer Chemet capsules Treatment of lead poisoning in children. 09.05.1984 22.12.1988

Metronidazole (topical) Metrogel Treatment of acne rosacea. 22.10.1987 22.11.1988

Interferon alfa-2a (recombinant) Roferon-A Treatment of AIDS related Kaposi's sarcoma. 14.12.1987 21.11.1988

Treatment of selected patients with Interferon alfa-2b (recombinant) Intron A Treatment of AIDS-related Kaposi's sarcoma. AIDS-related Kaposi's sarcoma. 24.06.1987 21.11.1988

For rescue use after high dose methotrexate therapy in Leucovorin Leucovorin calcium the treatment of osteosarcoma. 17.08.1988 31.08.1988 Prevention of cystine nephrolithiasis in patients with Tiopronin Thiola homozygous cystinuria. For the use of high dose methotrexate 17.01.1986 11.08.1988 with leucovorin rescue in patients with non-metastatic osteosarcoma who Methotrexate sodium Methotrexate TreatmentFor adjunctive of osteogenic therapy in sarcoma.the prevention and treatment have undergone surgical resection or 21.10.1985 07.04.1988 of hyperammonemia in patients with urea cycle enzymopathy due to carbamylphosphate synthetase, Benzoate and phenylacetate Ucephan ornithine, transcarbamylase, or argininosuccinate 21.01.1986 23.12.1987

Treatment of acute myelogenous leukemia, also Mitoxantrone HCl Novantrone Diagnosticreferred to asagent acute to assistnonlymphocytic in establishing leukemia. the diagnosis 13.07.1987 23.12.1987 in patients presenting with clinical and laboratory Teriparatide Parathar evidence of hypocalcemia due to either For chronic replacement therapy of 09.01.1987 23.12.1987 individuals having congenital Alpha1-proteinase inhibitor For replacement therapy in the alpha-1-proteinase deficiency of alpha1- proteinase (human) Prolastin Asinhibitor an adjunct congenital in leukapheresis deficiency state. to improve the inhibitor with clinically demonstrable 07.12.1984 02.12.1987 harvesting and increase the yield of leukocytes by Pentastarch Pentaspan Treatmentcentrifugal ofmeans. hypercalcemia of malignancy 28.08.1985 19.05.1987 inadequately managed by dietary modification and/or Etidronate disodium Didronel oral hydration. 21.03.1986 21.04.1987

Zidovudine Retrovir Treatment of AIDS. 17.07.1985 19.03.1987

Zidovudine Retrovir Treatment of AIDS related complex. 17.07.1985 19.03.1987 For the long-term treatment of children who have growth failure due to inadequate secretion of normal Somatropin for injection Humatrope Treatmentendogenous of growthpatients hormone. with congenital coagulopathies 12.06.1986 08.03.1987 who are undergoing surgical procedures (e.g. dental Tranexamic acid Cyklokapron extractions). 29.10.1985 30.12.1986 Treatment of lepromatous leprosy, including dapsone- resistant lepromatous leprosy and lepromatous leprosy Clofazimine Lamprene complicated by erythema nodosum leprosum. 11.06.1984 15.12.1986

Treatment of symptomatic Paget's disease (osteitis Calcitonin-human for injection Cibacalcin Fordeformans). induction of ovulation in patients with polycystic 20.01.1987 31.10.1986 ovarian disease who have an elevated LH/FSH ratio and who have failed to respond to adequate Urofollitropin Metrodin clomiphene citrate therapy. 25.11.1987 18.09.1986 Treatment of potentially life threatening digitalis intoxication in patients who are refractory to Digoxin immune FAB (Ovine) Digibind management by conventional therapy. 01.11.1984 22.04.1986

Levocarnitine Carnitor Treatment of genetic carnitine deficiency. 28.02.1984 10.04.1986

Treatment of patients with Wilson's disease who are Trientine HCl Syprine intolerant, or inadequately responsive to penicillamine. 24.12.1984 08.11.1985

For dissolution of cholesterol gallstones retained in the Monooctanoin Moctanin Forcommon long-term bile duct. treatment of children who have growth 30.05.1984 31.10.1985 failure due to a lack of adequate endogenous growth Somatrem for injection Protropin hormone secretion. 09.12.1985 17.10.1985 For use in the long-term treatment of children who have growth failure due to a lack of adequate endogenous Somatropin Nutropin growth hormone secretion. 06.03.1987 17.10.1985 For avoidance of the complication of calcium stone Potassium citrate Urocit-K formation in patients with uric lithiasis. 01.11.1984 30.08.1985

Prevention of calcium renal stones in patients with Potassium citrate Urocit-K hypocitraturia. 01.11.1984 30.08.1985

Potassium citrate Urocit-K PreventionFor blockade of ofuric the acid pharmacological nephrolithiasis. effects of 01.11.1984 30.08.1985 exogenously administered opioids as an adjunct to the maintenance of the opioid-free state in detoxified Naltrexone HCl Trexan formerly opioid-dependent individuals. 11.03.1985 30.11.1984 Pentamidine isethionate Pentam 300 Treatment of Pneumocystis carinii pneumonia. 28.02.1984 16.10.1984

Cromolyn sodium 4% ophthalmic solution Opticrom 4% ophthalmiForTreatment patients of with vernal radiolucent keratoconjunctivitis. stones in well opacifying 24.07.1985 03.10.1984 gallbladders, in whom elective surgery would be undertaken except for the presence of increased Chenodiol Chenix Ameliorationsurgical risk dueof recurrent to systemic attacks disease of acute or age. intermittent 21.09.1984 28.07.1983 porphyria (AIP) temporarily related to the menstrual cycle in susceptible women and similar symptoms Hemin Panhematin which occur in other patients with AIP, porphyria 16.03.1984 20.07.1983 (+/-)-7-[3-(4-acetyl-3-methoxy-2- propylphenoxy)propoxy]-3,4- Prevention of serious adverse events associated with dihydro-8-propyl-2H-1-benzopyran- vascular leak syndrome caused by Interleukin-2 therapy 31.03.2003 (+/-)-cis-3-(4-hydroxyphenyl)-4-(4- methoxyphenyl)-3,4-dihydro-2H- Treatment of Stage IIB through Stage IV malignant cromen-7-ol melanoma 01.02.2008 (+/-)-cis-3-(4-hydroxyphenyl)-4-(4- methoxyphenyl)-3,4-dihydro-2H- cromen-7-ol Treatment of pancreatic cancer 10.01.2008 (+/-)-cis-3-(4-hydroxyphenyl)-4-(4- methoxyphenyl)-3,4-dihydro-2H- cromen-7-ol Treatment of cholangiocarcinoma 10.01.2008 (1R,2R)-Octanoic acid [2-(2',3'- dihydrobenzo[1,4]dioxin-6'-yl)-2- (1R,2S)hydroxy-l-pyrrolidin-1-ylmethyl- 6-bromo-alpha-[2- Treatment of Gaucher disease 17.09.2008 (dimethylamino)ethyl]-2-methoxy- alpha-(1-naphthyl)-beta-phenyl-3- quinolineethanol Treatment of pulmonary tuberculosis (active disease) 10.01.2005 (1S)-1-(9-deazahypoxanthin-9-yl)- Treatment of chronic lymphocytic leukemia and related 1,4-dideoxy-1,4-imino-D-ribitol- leukemias to include prolymphocytic leukemia, adult T- hydrochloride cell leukemia, and hairy cell leukemia 10.08.2004 (1S)-1-(9-deazahypoxanthin-9-yl)- 1,4-dideoxy-1,4-imino-D-ribitol- hydrochloride Treatment of acute lymphoblastic leukemia 13.08.2004 (1S)-1-(9-deazahypoxanthin-9-yl)- 1,4-dideoxy-1,4-imino-D-ribitol- Treatment of T-cell non-Hodgkin's lymphoma 29.01.2004 (2Z)-2-cyano-3-3hydroxy-N-[4- Prevention of acute rejection following kidney, heart, (trifluoromethly)phenyl]-2-hepten-6- FK778 and liver tranplantation 10.01.2005 (3S)-3-(4- trifluoromethoxybenzyloxy)-6-nitro- 2H-3,4-dihydroimidazo[2,1- Treatment of tuberculosis. 05.07.2007 (3S)-3-[(2S)-2-({N-[2-tert- butyl)phenyl]carbamoyl}carbonyla Treatment of patients undergoing solid organ mino) propanoylamino]-4-oxo-5- transplantation. 19.08.2003 (4S)-4-ethyl-4-hydroxy-3,14-dioxo- 3,4,12,14-tetrahydro-1-H- pyrano[3?,4?:6,7]-indolizino-[1,2-b]-Gimatecan Treatment malignant glioma 29.11.2002

(6R,S)5,10-methylene- For use in combination with 5-fluorouracil for the tetrahydrofolic acid CoFactor treatment of patients with pancreatic cancer 13.08.2004 (9-[N-(3-morpholinopropyl)- Prevention of post-operative complications of aortic sulfonyl]-5,6-dihydro-5-oxo-11-H- anuerysm surgical repair 08.12.2004 (R)-2-methyl-6-nitro-2-{4-[4-(4- trifluoromethoxyphenoxy)piperidin- 1-yl]phenoxymethyl}-2,3- Treatment of pulmonary tuberculosis. 12.07.2007 (R)-4-(3-morpholin-4-yl-1- phenylsulfanylmethyl-propylamino)- N-(4-{4-[2-(4-chlorophenyl)-5,5- Treatment of small cell lung cancer 19.12.2007 (R)-4-(3-morpholin-4-yl-1- phenylsulfanylmethyl-propylamino)- (R)-4-(3-morpholin-4-yl-l-N-(4-{4-[2-(4-chlorophenyl)-5,5- Treatment of multiple myeloma 05.05.2008 phenylsulfanylmenthyl- propylamino)-N-(4-{4-[2-(4- chlorophenyl)-5,5- Treatment of chronic lymphocytic leukemia 19.12.2007

(R)-N-[2-(6-chloro-5-methoxy-1H- Treatment of circadian rhythm sleep disorders in blind indol-3-yl)propyl]acetamide people with no light perception 03.10.2001

(R)-N-[2-(6-Chloro-methoxy-1H- Treatment of neuroleptic-induced tardive dyskinesia in indol-3yl)propyl]acetamide schizophrenia patients 03.07.2003

Treatment of chronic iron overload in patients with (s)-3'-(HO)-DADFT-PE transfusion-dependent anemias 04.02.2009

(UDU-stereoisomer of c-UJUun UNU-terminal UkUnhibitor) Treatment of acute sensorineural hearing loss 28.03.2006

(Z-8-methyl-N-vanillyl-6- nonnamide) ; Civamide Treatment of postherpetic neuralgia. 17.02.2009 [131I]-N-(2-(diethylamino) ethyl-4- (4 flurobenzamido)-5-(iodo)-2- Treatment of metastatic melanoma, stages IIB, IIC, III methoxybenzamide and IV 17.09.2008 [5,10,15,20-tetrakis(1,3- diethylimidazolium-2- yl)porphyrinato] Treatment of Amyotrophic Lateral Sclerosis 04.11.2003

Treatment of gastro-entero-pancreatic neuroendocrine [Lu-177]-DOTA-Tyr3-Octreotate tumors 12.01.2009

[Nle4, D-Phe7]-a-melanocyte stimulating hormone Treatment of erythropoietic porphyrias 17.07.2008

1,5-(Butylimino)-1,5 dideoxy,D- glucitol Treatment of Fabry's disease. 12.05.1998 11-(2-Pyrrolidin-1-yl-ethoxy)-14,19- dioxa-5,7,26-triaza- For treatment of myeloproliferative disorders (MPD) tetracyclo[19.3.1.12,6.18,12}hepta with the JAK2 V617F mutation. 13.03.2008 Treatment of somatostatin receptor positive 111Indium pentetreotide SomatoTher neuroendocrine tumors. 10.06.1999

166Ho-DOTMP Treatment of multiple myeloma. 10.02.1999

17 a-Hydroxyprogesterone caproate Gestiva Prevention of preterm birth in singleton pregnancies 25.01.2007 17-allylamino-17- demethoxygeldanamycin (17- AGG) For the treatment of chronic myelogenous leukemia. 03.09.2004

1-Deoxygalactonojirimycin Treatment of Fabry Disease 25.02.2004

1-dexynojirimycin hydrochloride Treatment of Pompe disease 18.06.2007

2 dimethylbutyrate Treatment of beta thalassemia 18.06.2008 2-(2-phenylvinyl)-4-[4- methylpiperazin-l-yl)]-6-(5-methyl- 2H-pyrazol-3-yl-amino)-pyrimidine Treatment of multiple myeloma. 22.12.2008 2-(2-phenylvinyl)-4-[4- methylpiperazin-l-yl)]-6-(5-methyl- 2H-pyrazol-3-ylamino)-pyrimidine Treatment of ovarian carcinoma 18.03.2009 2-(3,5-dichloro-phenyl)- benzoxazole-6-carboxylic acid Treatment of familial amyloid polyneuropathy 23.05.2006 2-(3-diethylaminopropyl)-8,8- dipropyl-2-azaspiro [4,5] decan Treatment of mulitple myeloma and associated bone dimaleate Atiprimod resorption 02.12.2003 2-(3-Diethylaminopropyl)-8,8- dipropyl-2-azaspiro[4,5] decane dimaleate Atiprimod Treatment of carcinoid tumors 18.09.2006

2,6-Benzothiazolediamine,2',3',5'-tri-o-acetyluridine 4,5,6,7- Treatment of mitochondrial disease 13.01.2003 tetrahydro-N6-propyl-, dihydrochloride, monohydrate, (6R)-; (6R)-4,5,6,7-tetrahydro-N6- Treatment of amyothrophic lateral sclerosis (ALS). 11.10.2007 2-[(3-methyl-4-(2,2,2- trifluoroethoxy) pyridin-2- yl)methylsulfinyl] -1H- PreVonco (tm) Treatment of hepatocellular carcinoma. 27.08.2008

2-[(R)-2-methylpyrrolidin-2-yl]-1H- Treatment of malignant melanoma stages IIb through benzimadazole-4-carboxamide IV. 18.12.2007

2-[(R)-2-methylpyrrolidin-2-yl]-1H- Treatment glioblastoma multiforme when used in benzimadazole-4-carboxamide combination with DNA-damaging agents 09.05.2008

2-0-Butyryl-1-0-octyl-myo-inositol 3,4,5,6-tetrakisphosphate Treatment of cystic fibrosis 15.08.2003

2-0-desulfated heparin Aeropin Treatment of cystic fibrosis. 17.09.1993

20-mer complementary to Akt mRNA Treatment of stomach cancer 10.12.2004

20-mer oligonucleotide complementary to Akt mRNA Treatment of pancreatic cancer 08.12.2004

20-mer oligonucleotide complementary to Akt mRNA Treatment of glioblastoma 08.12.2004 20-mer oligonucleotide complementary to Akt mRNA Treatment of renal cell carcinoma 01.12.2004

20-mer oligonucleotide complementary to Akt mRNA Treatment of ovarian cancer 01.12.2004 2'-3'-dideoxyadenosine Treatment of aquired immunodeficiency syndrome. 21.07.1987

24,25 dihydroxycholecalciferol Treatment of uremic osteodystrophy. 27.02.1987

2-chloroethyl-3-sarcosinamide-1- nitrosourea Treatment for malignant gliomas 03.08.2001

2-chloroethyl-3-sarcosinamide-1- nitrosourea Sarmustine Treatment for malignant glioma 15.11.2001

As a host-protective agent in the treatment of acute 2'-deoxycytidine myelogenous leukemia. 09.09.1996

2-iminobiotin Treatment of perinatal asphyxia. 24.02.2009

2-methoxyestradiol PulmoLAR Treatment of pulmonary arterial hypertension 11.04.2005

2-methoxyestradiol Panzem NCD Treatment of ovarian cancer 04.04.2005

2-methoxyestradiol Panzem Treatment of multiforme glioblastoma 16.06.2006

2-methoxyestradiol Panzem Treatment of multiple myeloma 10.07.2001

2'-O-methyl-phosphorothiolate oliogribonucleotide Treatment of Duchenne muscular dystrophy 18.11.2005

3-(3,5-Dimethyl-1H-2ylmethylene)- 1,3-dihydro-indol-2-one Treatment of von Hippel-Lindau disease. 23.03.2000

3-(3,5-dimethyl-1H-2ylmethylene)- 1,3-dihydro-indol-2-one Treatment of Kaposi's sarcoma. 11.09.1998

3,4-diaminopyridine Treatment of Lambert-Eaton myasthenic syndrome. 18.12.1990 Treatment of well-differentiated papillary, follicular or combined papillary/follicular carcinomas of the thyroid 3,5,3'-triiodothyroacetate gland. 20.09.2000

3-[5-(2-fluoro-plhenyl)- Treatment of Muscular Dystrophy resulting from [1,2,4]oxadiazole-3-yl]benzoic acid premature stop mutations in the dystrohin gene 10.01.2005 For use in the treatment of cystic fibrosis resulting fron 3-[5-(2-fluoro-plhenyl)- a nonsense (premature stopcodon) mutation in the [1,2,4]oxadiazole-3-yl]benzoic acid cystic bibrosis transmembrane conductance regulatory 01.09.2004

3-[5-(2-fluoro-plhenyl)- [1,2,4]oxadiazole-3-yl]benzoic acid Treatment of spinal muscular atrophy. 10.03.2008

3'-azido-2',3'dideoxyuridine AZDU Treatment of acquired immunodeficiency syndrome. 20.11.1989 3-fluoro-5-[5-(2-menthyl-thiazol-4- ylethylnyl)-pyridin-2-yl]-benzonitrile Treatment of behavioral abnormalities associated with dihydrochloride fragile X syndrome. 28.07.2008

4-(2-fluorophenyl)-6-methyl-2-(1- Treatment of Chronic Functional Vomiting to include piperzinyl) functional vomiting and cyclic vomiting syndrome. 11.10.2006

4-(3-Methanesulfonyl-phenyl)-1- propylpiperidine HCl Treatment of Huntington disease. 12.12.2005 4, 5 dibromorhodamine methyl ester Theralux PhotodynamicTreatment of follicular lymphoma 30.10.2008

4, 5 dibromorhodamine methyl ester Theralux PhotodynamicTreatment of diffuse large B-cell lymphoma 30.10.2008 For immune reconstitution and prevention of graft 4,5 dibromorhodamine methyl versus host disease following allogeneic hematopoietic ester Theralux Photodynamicstem cell transplantation. 23.10.2007

4,5-dibromorhodamine 123 Theralux Irradiation DeTreatment of chronic myelogenous leukemia 10.04.2003 4,6,8-trihydroxy-10-(3,7,11- trimethyldodeca-2,6,10-trienyl)- Treatment of malignanat glioma 27.04.2009 4-[[[4-(4- Prophylaxis of organ rejection in patients receiving Chlorophenoxy)phenyl]sulfonyl]- allogeneic liver transplants 18.06.2008 4-[1]benzofuro[3,2-d]pyrimidin-4-yl- Treatment, in combination with radiotherapy and N-(1,3-benzodioxol-5- temozolomide chemotherapy, of patients with ylmethyl)piperazine-1- Treatmentglioblastoma of multiforme.chronic iron overload resulting from 30.07.2008 conventional transfusional treatment of beta- 40SD02 thalassemia major and sickle cell anemia. 21.12.1998 4-Amino-1-[5-O-[(2R, 4S)-2-oxido- 4-(4-pyridinyl)-1, 3, 2- dioxaphosphorinan-2-yl]-b-D- Treatment of hepatocellular carcinoma. 22.08.2007

Treatment chronic functional motor and sensory deficits 4-Aminopyridine from Guillain-Barre syndrome 14.12.2005 Treatment of acute flares in pediatric patients with ileo- 4-aminosalicylic acid Paser Granules cecal Crohn's disease 26.04.2006

Treatment of mild to moderate ulcerative colitis in 4-aminosalicylic acid Pamisyl (P-D), Rezipaspatients intolerant to sulfasalazine. 13.12.1989

4-cholest-en-3-one, oxime Treatment of amyotrophic lateral sclerosis 01.12.2005 4-cyano-N-[2-(1-cyclohexen-1-yl)- 4-[1-[dimethylamino)acetyl]-4- piperidinyl]phenyl]-1H-imidazole-2- Treatment of acute myeloid leukemia 20.07.2006 4-trifluoromethyl-N- (3.3a.4.4a.5,5a,6,6a-octahydro-1,3- dioxo- Treatment of smallpox. 27.12.2006 4-trifluoromethyl-N- (3.3a.4.4a.5,5a,6,6a-octahydro-1,3- dioxo- post exposure prophylaxis against smallpox 18.12.2006

5(S)-(2'-hydroxy ethoxy)-20(S)- Camptothecin Treatment of osteosarcoma (bone cancer) 15.06.2007 5,12-Naphthacenedione, 10-[[3- amino-2,3,6-trideoxy-4-O- (phenylmethyl)-a-L-lyxo- Treatment of malignant gliomas 11.10.2006 5,5',5"-[Phosphinothioylidyne- tris(imino-2,1-ethanediyl)]tris[5- methylchelidoninium]trihydroide Treatment of pancreatic cancer 20.08.2003

5,6-dihydro-5-azacytidine Treatment of malignant mesothelioma. 11.05.1992

5,7-dihydroxy-3-(4-hydroxyphenyl)- chromen-4-one Prevention of acute radiation syndrome 18.06.2007

5-[(E)-2-(4-hydroxyphenyl)- ethenyl] benzene-1,3 diol Resveratrol Treatment of MELAS syndrome 13.03.2008

506U78 Treatment of chronic lymphocytic leukemia. 02.09.1999

For use in post-exposure prophylaxis for occupational 5a8, monoclonal antibody to CD4 exposure to human immunodeficiency virus. 20.12.1993

5-aza-2'-deoxycytidine Treatment of acute leukemia. 03.08.1987 5-Azacitidine Vidaza Treatment of acute myeloid leukemia 18.06.2008

5-hydroxymethyl-2-furfuraldehyde Treatment of sickle cell disease 26.05.2006 5-iodo-2-pytimidinone-2'- deoxyribose Treatment of malginant glioma 26.05.2006

5-methyl-1-phenyl-2-(1H)- pyridone(CAS 53179-13-8) Pirfenidone Treatment of idiopathic pulmonary fibrosis 05.03.2004

5'-O-(trans-9''-octadecenoyl)-1-B- D-arabinofuranosyl cytosine Treatment of acute myeloid leukemia. 18.06.2008

6 alpha-ethylchenodeoxycholic acid Treatment of primary biliary cirrhosis 09.04.2008 6,8-bis-benzylsulfanyl-octanoic acid Treatment of pancreatic cancer 06.02.2006 6-alpha-ethylchenodeoxycholic acid Treatment of primary sclerosing cholangitis 09.04.2008 Treatment of histologically confirmed advanced or 6-hydroxymethylacylfulvene metastatic pancreatic cancer. 06.04.1999

For use in conjunction with the UVAR photopheresis to 8-methoxsalen Uvadex treat diffuse systemic sclerosis. 22.06.1993

For the prevention of acute rejection of cardiac 8-methoxsalen Uvadex allografts. 12.05.1994

90Y-hPAMA4 PAN-Cide Treatment of pancreatic cancer 29.01.2004

Prevention of retinal detachment due to proliferative 9-cis-retinoic acid vitreoretinopathy. 02.01.1997

9-nitro-20-(S)-camptothecin Treatment of pancreatic cancer. 16.09.1996 Treatment of pediatric HIV- 9-nitro-20-(S)-camptothecin Camvirex Treatment of pediatric HIV infection/AIDS infection/AIDS patients 15.05.2001 a-(3-aminophthalimido) glutaramide Actimid Treatment of multiple myeloma 15.01.2003 A10 & AS2-1 Antineoplaston Treatment for patients with brain stem glioma 03.09.2004

Treatment of Leber congenital amaurosis due to RPE65 AAV2-hRPE65v2 mutations. 24.06.2008

Abetimus Treatment of lupus nephritis. 28.07.2000

ACA125 Treatment of epithelial ovarian cancer 25.11.2003

Intravenous treatment of patients presenting with Acetylcysteine Mucomyst/Mucomyst 1moderate to severe acetaminophen overdose. 13.08.1987

Treatment of acid sphingomyelinase deficiency Acid sphingomyelinase (Niemann-Pick disease). 03.08.2000

Adalimumab Humira Treatment of pediatric Crohn's disease. 19.10.2006 Adeno-associated vector expressing the human lipoprotein lipase protein Treatment of lipoprotein lipase deficiency 21.05.2007 Adeno-associated viral vector containing the gene for human Intramuscular treatment of patients with moderate to coagulation factor IX Coagulin-B severe hemophilia 13.06.2001 Adeno-associated viral vector containing the gene for human Intrahepatic treatment of patients with moderate to coagulation factor IX Coagulin-B severe hemophilia 13.06.2001 Adeno-associated viral vector expressing human acid alpha glucosidase gene Treatment of Pompe disease 20.03.2007 adeno-associated viral vector expressing human retinoschisin-1 gene Treatment of X-linked juvenile retinoschisis (XLRS). 21.05.2007 Adeno-associated viral vector serotype 5 containing human ABCA4 gene Treatment of Stargardt's disease. 30.09.2008

Adeno-associated viral-based vector cystic fibrosis gene therapy Treatment of cystic fibrosis. 15.02.1995 For use in conjunction with BCNU in the treatment of Adenosine brain tumors. 01.08.1989 Adenoviral vector expressing Herpes simplex virus thymidine kinase gene Treatment of malignant brain tumors 17.06.2005 Adenovirus-based vector Factor VIII complementary DNA to somatic cells MiniAdFVIII Treatment of hemophilia A. 15.12.1999 adenovirus-mediated herpes simplex virus-thymidine kinase Use with gancyclovir in the treatment of malignant gene glioma 31.07.2001

Aerosolized pooled immune Treatment of respiratory syncytial virus lower globulin respiratory tract disease. 03.01.1989 a-Galactosidase A Plant-Produced HumanTreatment of Fabry's disease 21.01.2003

Aglycosyl anti-CD3 monoclonal antibody Treatment of new-onset type I diabetes mellitus 06.02.2006

AI-RSA Treatment of autoimmune uveitis. 08.10.1992

Albuterol ToPrevention improve ofpatient paralysis outcomes due to by spinal decreasing cord injury time to 12.03.2002 platlet and neutrophil engraftment in patients with ALD-101 inherited metabolic diseases (IMD) undergoing 23.10.2008

Treatment of primary immunodeficiency disease Aldesleukin Proleukin associated with T-cell defects. 22.03.1989

Aldesleukin Proleukin Treatment of acute myelogenous leukemia. 31.07.1998

Aldesleukin Proleukin For the treatment non-Hodgkin's lymphoma. 24.11.1998

For use as prophylaxis of rejection in patients receiving Alefacept Amevive allogenic solid organ transplants. 19.12.2007 Treatment of osteogenesis imperfecta in pediatric alendronate Fosamax patients 4 years of age and older 31.03.2003 Treatment of the bone manifestations of Gaucher Alendronate disodium Fosamax disease 13.02.2001 Alfentanil Management of postherpetic neuralgia 08.07.2005

Alfentanil Treatment of painful HIV-associated neuropathy 09.08.2005

Replacement therapy in patients with Type II and III Alglucerase injection Ceredase Gaucher's disease. 21.07.1995 alicaforsen Treatment of pouchitis. 24.06.2008

Alitretinoin Panretin Treatment of acute promyelocytic leukemia 10.04.1992 Treatment of skin blistering and erosions associated allantoin Alwextin with inherited epidermolysis bullosa 21.11.2002 Allogeneic human aortic Prevention of arteriovenous fistula or arteriovenous endothelial cells cultured in a graft failure in patients with end satge renal disease porcine gelatin matrix Vascugel (r) receiving hemodialysis or preparing for hemodialysis 03.04.2009 Allogeneic human retinal pigment epithelial cells on gelatin Treatment of Hoehn and Yahr stage 3 and 4 microcarriers Spheramine TreatmentParkinson's of disease. insufficient hematopoietic stem cell 18.07.1997 allogeneic mesenchymal production in patients with hematologic malignancies precursor cells derived from ex who have failed treatment with conventional vivo healthy donors harvested chemotherapy. 12.09.2008 Allogeneic peripheral blood mononuclear cells sensitized against patient alloantigens by CYTOIMPLANT Treatment of pancreatic cancer 13.06.1997 Allogeneic retinal epithelial cells transfected with plasmid vector expressing ciliary neurotrophic ImmunotherapyTreatment of retinitis for acceleration pigmentosa of T-cell reconstitution 01.09.2004 Allogeneic T-cells cultured with in patients undergoing allogeneic hematopoietic stem anti-CD3 and IL-2; transduced cell transplantation with retroviral vector (SFCMM-3), 28.01.2005

Allopurinol riboside Treatment of cutaneous and visceral leishmaniasis. 04.12.1985

Allopurinol riboside Treatment of Chagas' disease. 04.12.1985 Ex-vivo preservation of cadaveric kidneys for Allopurinol sodium transplantation 09.11.1987

Alpha-1-acid glycoprotein Treatment of cocaine overdose 05.03.2004

Alpha-1-acid glycoprotein Treatment of tricyclic antidepressant poisoning 17.03.2004

Alpha-1-antitrypsin (recombinant As supplementation therapy for alpha-1-antitrypsin DNA Origin) deficiency in the ZZ phenotype population. 01.01.1984

Alpha1-antitrypsin(human) Treatment of bronchiectasis 03.04.2008

Alpha1-Proteinase Inhibitor Inhalation therapy for the the treatment of congential (Human) deficiency of alpha1-proteinase inhibitor. 22.12.2004

Alpha1-Proteinase Inhibitor (Human) ARC-API Treatment of cystic fibrosis 01.09.2004 alpha1-proteinase inhibitor (human) Treatment of cystic fibrosis 20.02.2009

Alpha1-proteinase inhibitor For slowing the progression of emphysema in alpha1- (human) antitrypsin deficient patients. 24.11.1999

Alpha-galactosidase A Fabrase Treatment of Fabry's disease. 20.07.1990

Treatment of alpha-galactosidase A deficiency (Fabry's Alpha-galactosidase A CC-galactosidase disease). 17.06.1991 Long-term enzyme replacement therapy for the Alpha-galactosidase A Replagal treatment of Fabry disease. 22.06.1998

Alpha-melanocyte stimulating Prevention and treatment of intrinsic acute renal failure hormone due to ischemia. 19.08.1997

Treatment of inherited mitochondrial respiratory chain Alpha-tocopherol quinone diseases 28.03.2006 Treatment of severe peripheral arterial occlusive disease (critical limb ischemia) in patients where other Alprostadil procedures, grafts or angioplasty, are not indicated. 20.10.1993 Treatment of intraventricular hemmorage associated alteplase Activase with intracerebral hemmorrhage 27.01.2003

Teatment of B-cell chronic lymphocytic leukemia (B- Alvocidib CLL) or prolymphocytic leukemia arising from CLL. 13.04.2007 ALX-0081 nanobody, directed towards the human A1 domain of von Willebrand factor Treatment of thrombotic thrombocytopenic purpura 14.04.2009

Treatment of thrombocytopenia associated with AMG 531 myelodysplasia syndrome 31.10.2007

Amifostine Ethyol Treatment of myelodysplastic syndromes. 04.10.1999 For use as a chemoprotective agent for cisplatin in the Amifostine Ethyol treatment of metastatic melanoma. 30.05.1990 cyclophosphamide in the treatment of advanced Amifostine Ethyol ovarian carcinoma. 30.05.1990

For the reduction of the incidence and severity of Amifostine Ethyol toxicities associated with cisplatin administration. 24.11.1998 Treatment of bronchopulmonary Pseudomonas Amikacin SLIT Amikacin aeruginosa infections in cystic fibrosis patients 09.03.2006

Amiloride HCl solution for inhalation Treatment of cystic fibrosis. 18.07.1990 For the topical treatment of traumatic hyphema of the Aminocaproic acid Caprogel eye. 06.01.1995

Aminolevulinic acid hydrochloride Levulan Treatment of esophageal dysplasia 20.03.2007

Aminosalicylate sodium Treatment of Crohn's disease. 06.04.1993

Aminosidine Paromomycin Treatment of visceral leishmaniasis 29.03.2005

Aminosidine Paromomycin Treatment of visceral leishmaniasis (kala-azar). 09.09.1994

Aminosidine Gabbromicina Treatment of tuberculosis. 14.05.1993 Aminosidine Gabbromicina Treatment of Mycobacterium avium complex. 15.11.1993

Amiodarone Amio-Aqueous Treatment of incessant ventricular tachycardia. 17.08.1993 ammonium tetrathiomolybdate Treatment of idiopathic pulmonary fibrosis 05.05.2008

Ammonium tetrathiomolybdate Coprexa Treatment of Wilson's disease. 31.01.1994

Amonafide L-malate Xanafide TreatmentPrevention ofof acutepulmonary myeloid fungal leukemia infections in patients at 20.12.2006 risk for aspergillosis due to immunosuppressive therapy including those receiving organ or stem cell transplants, Amphotericin B inhalation powder or teated with chemotherapy or radiation for 15.12.2005

Amphotericin B lipid complex Abelcet Treatment of invasive protothecosis. 21.08.1996

Amphotericin B lipid complex Abelcet Treatment of invasive sporotrichosis. 23.09.1996

Amphotericin B lipid complex Abelcet Treatment of invasive coccidioidomycosis. 06.05.1996

Amphotericin B lipid complex Abelcet Treatment of invasive zygomycosis. 06.05.1996

Amphotericin B lipid complex Abelcet Treatment of invasive candidiasis. 27.06.1996 amrubicin Treatment of small cell lung cancer 10.03.2008

Amsacrine Amsidyl Treatment of acute adult leukemia. 07.12.1984

Amyl nitrite, sodium nitrite, sodium thiosulfate Cyanide Antidote Kit Treatment of cyanide poisoning 18.12.2006

Treatment of thrombocytosis in chronic myelogenous Anagrelide Agrylin leukemia. 14.07.1986

Anagrelide Agrylin Treatment of polycythemia vera. 11.06.1985 Ananain, comosain Vianain For the enzymatic debridement of severe burns. 21.01.1992

Anaritide acetate Auriculin Treatment of patients with acute renal failure. 27.08.1992

Improvement of early renal allograft function following Anaritide acetate Auriculin Treatmentrenal transplantation. of patients having experienced a severe 10.04.1992 traumatic brain injury (Glasgow Coma Scale 3 to 8) in order to decrease early mortality and improve long-term Anatibant functional and neurological outcome 15.04.2005 To establish and maintain anticoagulation in heparin- intolerant patients undergoing cardiopulmonary bypass. Ancrod Viprinex 20.10.1989

Angiotensin 1-7 MARstem Treatment of myelodysplastic syndrome 03.08.2001

Treatment of neutropenia associated with autologous Angiotensin 1-7 bone marrow transplantation. 16.02.2000

Treatment of toxemia associated with inhalational anthrax immune globulin (human) anthrax. 29.07.2008 anti human Nogo-A human monoclonal antibody Treatment of acute spinal cord injury 20.10.2008 Anti pan T lymphocyte monoclonal For ex-vivo treatment to eliminate mature T cells from antibody Anti-t Lymphocyte Immpotential bone marrow grafts. 29.01.1986 Anti pan T lymphocyte monoclonal For in-vivo treatment of bone marrow recipients to antibody Anti-t Lymphocyte Immprevent graft rejection and graft versus host disease. 29.01.1986 antiangiogenic components extracted from marine cartilage Neovastat (AE-941) Treatment of renal cell carcinoma 16.10.2002 anti-CD23 IgG1, kappa monoclonal antibody Treatment of chronic lymphocytic leukemia 12.02.2003 anti-CD30 Fc engineered humanized monoclonal antibody Treatment of Hodgkin lymphoma 02.12.2008

Anti-CD40 mAb Treatment of chronic lymphocytic leukemia 06.10.2005

Prevention of acute graft rejection of human organ Anti-CD45 monoclonal antibodies transplants. 10.09.1990 Anti-CEA Sheep-human chimeric monoclonal antibody labeled w/iodine-131 (KAb201) Treatment of pancreatic cancer 21.05.2003

Anti-cytomegalovirus monoclonal Prevention of human cytomegalovirus infection in bone antibodies marrow and organ transplant patients. 02.05.1990

Anti-cytomegalovirus monoclonal Treatment of human cytomegalovirus infection in bone antibodies marrow and organ transplant patients. 02.05.1990

Anti-cytomegalovirus monoclonal Prevention of human cytomegalovirus infection in antibodies patients diagnosed with AIDS. 03.05.1990

Anti-cytomegalovirus monoclonal Treatment of human cytomegalovirus infection in antibodies patients diagnosed with AIDS. 03.05.1990 Anti-cytotoxic T lymphocyte antigen 4 monoclonal antibody Treatment of stage IIb to stage IV metastatic melanoma 18.09.2006

Treatment of drug resistant generalized tonic-clonic Antiepilepsirine epilepsy in children and adults. 23.03.1989 Antihemophilic factor (recombinant) formulated with sucrose reconstituted with Kogenate(r) FS Treatment of hemophilia A 29.04.2009 anti-interferon-gamma Fab from For the treatment of immunologic corneal allograft goats rejection 18.11.2003

Antimelanoma Antibody XMMME- Diagnostic use in imaging systemic and nodal 001-DTPA 111 Indium Antimelanoma Antibodymelanoma metastasis. 14.11.1984

Antimelanoma Antibody XMMME- Treatment of stage III melanoma not amenable to 001-RTA Antimelanoma Antibodysurgical resection. 14.11.1984 antineoplaston A10, antineoplaston AS2-1 Treatment of gliomas 30.10.2008

For use as an index of hepatic drug-metabolizing Antipyrine Test capacity. 21.02.1985 Antisense 20-mer oligonucleotide complementary to R2 component Treatment of acute myeloid leukemia 15.04.2005 antisense 20-mer phosphorothioate oligonucleotide [complementary to the coding GTI-2040 Treatment for renal cell carcinoma 12.03.2003 Antisense inhibitor of apoB-100 Treatment of homozygous familial hypercholesterolemia 23.05.2006

Antisense oligonucleotide directed against connexin43 Nexagon Treatment of persistent corneal epithelial defects 27.04.2009

Anti-T cell receptor murine Prophylaxis of acute rejection of solid organ monoclonal antibody transplantation 03.04.2009

Anti-tap-72 immunotoxin Xomazyme-791 Treatment of metastatic colorectal adenocarcinoma. 06.03.1987

Anti-tenascin 81C6 monoclonal antibody labeled w/ I 131 Neuradiab Treatment of primary malignant brain tumors 04.10.2005

Antithrombin III (human) For prophylaxis and treatment of thromboembolic concentrate IV Kybernin P Preventingepisodes in orpatients arresting with episodes genetic AT-IIIof thrombosis deficiency. in 02.07.1985 patients with congenital AT-III deficiency and/or to Antithrombin III human Antithrombin III humanprevent the occurrence of thrombosis in patients with 02.01.1986

Anti-thymocyte Globulin (Rabbitt) Thymoglobulin Treatment of myelodysplastic syndrome (MDS) 06.09.2000

Treatment of allograft rejection, including solid organ (kidney, liver, heart, lung, and pancreas) and bone Anti-thymocyte serum Nashville Rabbit Anti-thmarrow transplantation. 02.06.1993 anti-T-lymphocyte immune Prophylaxis of acute allograft rejection in adult globulin, rabbit recipients in solid organ transplantation. 12.09.2008

Antivenin crotaline (pit-viper) equine immune F(ab)2) Antivipmyn Treatment of envenomation by Crotaline snakes 29.01.2004

Antivenom (crotalidae) purified Treatment of envenomation by poisonous snakes (avian) belonging to the Crotalidae family. 12.02.1991

Anti-von Willebrand Aptamer Treatment of thrombotic thrombocytopenic purpura 09.04.2008

Treatment of acute graft-versus-host disease in AP1903 patients undergoing bone marrow transplantation. 24.11.1999 APL 400-020 V-Beta DNA vaccine Treatment of cutaneous T cell lymphoma. 08.03.1995

For use as rescue treatment for early morning motor Apomorphine dysfunction in late-stage Parkinson's disease. 20.10.1997

Treatment of the on-off fluctuations associated with late- Apomorphine Forstage the Parkinson's treatment ofdisease. patients in a vegetative state or 17.07.1995 minimally conscious state for up to 12 months following Apomorphine hydrochloride a severe traumatic brain injury (traumatic or 23.05.2006

AQ-13 (4-aminoquinoline analog) Treatment of malaria 12.09.2008

Diagnosis and localization of primary, residual, Arcitumomab 99m Tc-labeled CEA-Srecurrent and metastatic medullary thyroid carcinoma. 10.05.1996

Arenegyr Treatment of malignant plueral mesothelioma 22.08.2008

Arginine butyrate Treatment of sickle cell disease and beta thalassemia. 25.05.1994

Treatment of beta-hemoglobinopathies and beta- Arginine butyrate thalassemia. 07.04.1992 arimoclomol Treatment of amyotrophic lateral sclerosis 29.03.2005

Aripiprazole Abilify Treatment of Tourette's syndrome 25.01.2006

Treatment of acute myelocytic leukemia subtypes M0, arsenic Trisenox M1, M2, M4, M5, M6 and M7 02.11.2001

Arsenic trioxide Trisenox Treatment of malignant glioma 04.03.2005 arsenic trioxide Trisenox Treatment of chronic myeloid leukemia 18.10.2001

Arsenic trioxide Trisenox Treatment of multiple myeloma. 28.04.2000 arsenic trioxide Trisenox Treatment of liver cancer 13.06.2003

Arsenic trioxide Trisenox Treatment of chronic lymphocytic leukemia 13.05.2003 arsenic trioxide Trisenox Treatment of myelodysplastic syndrome. 17.07.2000 For the treatment of infections due to Plasmodium artemether/lumefantrine Coartem falciparum or mixed infections including P. falciparum. 31.08.2007

Artesunate Treatment of malaria. 19.07.1999

Artesunate Immediate treatment of malaria 28.03.2006 arylsulfatase A (rhARSA) Treatment of metachromatic leukodystrophy. 27.02.2008

As-101 Treatment of acquired immunodeficiency syndrome. 09.11.1987

Ascorbic acid Ascor L 500 Treatment of scurvy 31.08.2007

Atomoxetine hydrochloride STRATTERA Treatment of Tourette's Syndrome 26.08.2003

Primary prophylaxis of HIV-infected persons at high risk Atovaquone Mepron for developing Toxoplasma gondii encephalitis. 16.03.1993 Treatment and suppression of Toxoplasma gondii Atovaquone Mepron encephalitis. 16.03.1993 Attenuated autologous cancer cells and granulocyte macrophage Treatment of primary central nervous system colony stimulating factor in malignancies 27.04.2007 autologous antigen presenting cells pulsed with autologous tumor Mylovenge Treatment of multiple myeloma 18.04.2002 Autologous cultured endothelial cells on a donor human corneal Treatment of Fuch's dystrophy, pseudophakic bullous disk keratopathy, and bullous keratopathy 01.06.2007 Autologous dendritic cells pulsed with autologous antigens from primay malignant brain tumor cells DCVax-Brain ForTreatment adjuvant of therapyprimary inbrain melanoma malignant patients cancer with 29.11.2002 Autologous DNP-conjugated tumor surgically resectable lymph node metastasis (Stage III vaccine M-Vax and limited Stage IV disease). 23.02.1999

Therapy to improve the motor and sensory neurological Autologous incubated macrophage outcome in acute cases of spinal cord injury 03.09.2004 autologous lymphocytes depleted ex vivo of immunoreactive T cells Theralux photodynamicTreatment of chronic graft versus host disease 03.04.2008 autologous olfactory neural progenitors RhinoCytes Treatment of amyotrophic lateral sclerosis 31.12.2008

Autologous olfactory neural Treatment of spinal cord injury patients with ASIA progenitors RhinoCytes Impairment grades A, B, or C 01.02.2008 Autologous or allogeneic limbal epithelial stem cells expanded ex Treatment of ocular surface diseases that are vivo on human amniotic characterized by total limbal stem cell deficiency 14.07.2005 autologous tumor-derived gp96 heat shock protein-peptide complex Oncophage Treatment of renal cell carcinoma 10.05.2002 autologous tumor-derived gp96 heat shock protein-peptide complex Oncophage Treatment of metastatic melanoma 11.07.2002

Autolymphocyte therapy Treatment of renal cell carcinoma. 12.07.1994 aviptadil Treatment of pulmonary arterial hypertension 22.02.2005 axitinib Treatment of pancreatic cancer 31.05.2007

Treatment of oral manifestations of graft-versus-host Azathioprine Imuran disease. 14.09.1999

Inhalation therapy for control of gram-negative bacteria aztreonam in the respiratory tract of patients with cystic fibrosis 12.03.2002

Bacillus Calmette-Guerin vaccine Treatment of stage IIb through IV metastatic melanoma 09.08.2006 Treatment of antibiotic-associated pseudomembranous enterocolitis caused by toxins A and B elaborated by Bacitracin Altracin Clostridium difficile. 13.03.1984

Treatment of intractable spasticity due to multiple Baclofen sclerosis or spinal cord injury. 16.12.1991

Baclofen Lioresal Intrathecal Treatment of spasticity associated with cerebral palsy. 26.09.1994 baclofen Treatment of dystonia 02.12.2003

Bardoxolone Treatment of pancreatic cancer 06.08.2008

beclomethasone Treatment of pediatriac patients with ulcerative colitis 04.03.2009 beclomethasone 17,21- dipropionate Bec Prevention of gastrointestinal graft-versus-host disease 28.08.2001 beclomethasone 17,21- diproprionate Treatment of pediatric patients with Crohn disease. 18.12.2007

For oral administration in the treatment of intestinal Beclomethasone dipropionate graft-versus-host disease. 27.03.1998

Prophylaxis of organ rejection in renal allograft belatacept recipients 20.02.2008 Benzophenone-3, For the prevention of visible light induced skin octylmethoxycinnamate, photosensitivity as a result of porfimer sodium avobenzone, titanium dioxide, zinc Total Block VL SPF 75photodynamic therapy 13.08.2001

Prophylactic treatment of oral mucositis resulting from Benzydamine hydrochloride Tantum Assessingradiation therapy the risk for of head administrating and neck penicillincancer. when it is 18.05.1998 Benzylpenicillin, benzylpenicilloic, the preferred drug of choice in adult patients who have benzylpenilloic acid Pre-Pen/MDM previously received penicillin and have a history of 29.09.1987 failure caused by meconium aspiration syndrome, Beractant Survanta Intratracheal TreatmentpersistentS pulmonaryof pulmonary hypertension arterial hypertension of the newborn, or 20.12.1993 associated with any New York Heart Association Beraprost classification (Class I, II, III, or IV). 29.04.1999 Beta alethine Betathine Treatment of metastatic melanoma. 24.03.1997

Beta alethine Betathine Treatment of multiple myeloma. 24.03.1997

Treatment of obesity associated with Prader Willi Betahistine dihydrochloride syndrome 08.11.2007

Prevention of recurrence of primary ventricular Bethanidine sulfate fibrillation. 24.11.1989

Bethanidine sulfate Treatment of primary ventricular fibrillation. 20.09.1988

Betulinic acid Topical treatment of metastatic melanoma 09.08.2007

Bevacizamub Avastin Treatment of malignant glioma 26.05.2006

Bevacizumab Avastin Therapeutic treatment of patients with ovarian cancer 09.02.2006

Bevacizumab Avastin Treatment of pancreatic cancer 20.10.2004

Bevacizumab Avastin Treatment of renal cell carcinoma 06.11.2003 bifidobacterium infantis 35624 Treatment of pediatric ulcerative colitis 24.03.2008 bifidobacterium longum infantis 35624 Treatment of pediatric Crohn's disease 16.01.2003

Bindarit Treatment of lupus nephritis. 03.02.1998 Bioartificial liver system utilizing Treatment of patients with acute liver failure presenting xenogenic hepatocytes in a hollow with encephalopathy deteriorating beyond Parson's fiber bioreactor cartridge (BAL) phenotypegrade 2 to 11.02.2002 substitute for the normal corneal epithelium that is lost Bio-engineered oral mucosal in patients due to total limbal stem cell deficiency tissue 27.04.2006

Bis(4- fluorophenyl)phenylacetamide Treatment of sickle cell disease. 02.03.2000 Bispecific molecule with two linked murine single-chain Fv regions against CD3 & CD19 Treatment of prolymphocytic leukemia 16.05.2008 Bispecific molecule with two linked murine single-chain Fv regions against CD3 & CD19 Treatment for hairy cell leukemia. 16.05.2008 Bispecific molecule with two linked murine single-chain Fv regions Treatment of chronic lymphocytic leukemia 16.05.2008 Bispecific molecule with two linked murine single-chain Fv regions against CD3 & CD19 Treatment of acute lymphocytic leukemia 16.05.2008 Bispecific molecule with two linked murine single-chain Fv regions Treatment of indolent B-cell lymphoma, excluding CLL directed against CD3 & CD19 and NHL with CNS involvement 06.02.2006 For use as an anticoagulant in patients with or at risk of heparin-induced thrombocytopenia/heparin-induced bivalirudin Angiomax thrombocytopenia thrombosis syndrome 02.11.2005

Bleomycin Blenoxane Treatment of pancreatic cancer. 09.02.1999

BMY-45622 Treatment of ovarian cancer. 15.10.1990 bosentan Tracleer Treatment of idiopathic pulmonary fibrosis 30.09.2008 bosutinib Treatment of chronic myelogenous leukemia.

Treatment of dynamic muscle contractures in pediatric Botulinum toxin type A Dysport cerebral palsy patients. 20.10.1999

Botulinum toxin type A Dysport Treatment of spasmodic torticollis (cervical dystonia). 12.08.1998

Botulinum toxin type A Dysport Treatment of essential blepharospasm. 23.03.1989

Treatment of dynamic muscle contracture in pediatric Botulinum toxin type A Botox cerebral palsy patients. 06.12.1991 Treatment of synkinetic closure of the eyelid associated Botulinum toxin type A with VII cranial nerve aberrant regeneration. 15.09.1992

Botulinum toxin type F Treatment of spasmodic torticollis (cervical dystonia). 24.10.1991

Botulinum toxin type F Treatment of essential blepharospasm. 05.12.1991

Bovine colostrum Treatment of AIDS-related diarrhea. 19.11.1990 Bovine immunoglobulin Treatment and symptomatic relief of Cryptosporidium concentrate, Cryptosporidium parvum infection of the gastrointestinal tract in parvum Sporidin-G Treatmentimmunocompromised of cryptosporidiosis patients. caused by the presence 01.03.1994 of Cryptosporidium parvum in the gastrointestinal tract of patients who are Bovine whey protein concentrate Immuno-C immunodeficient/immunocompromised or 30.09.1993

Branched chain amino acids Treatment of amyotrophic lateral sclerosis. 23.12.1988

Brimonidine Alphagan Treatment of anterior ischemic optic neuropathy. 07.02.2000

Brivaracetam Treatment of symtomatic myoclonus 05.10.2005

Brivudin Adjunct treatment of pancreatic cancer 15.11.2007

Treatment of mild to moderate keratoconjunctivitis Bromhexine Bisolvon sicca in patients with Sjogren's syndrome. 15.05.1989

Radiation sensitizer in the treatment of primary brain Broxuridine Broxine/Neomark tumors. 18.09.1995

For use in combination with paclitaxel in the treatment bryostatin-1 of esophageal cancer 03.12.2001

Buffered Ursodeoxycholic Acid Ursocarb Treatment of pruritus in patients with Alagille Syndrome 03.09.2004

Relief of persistent pain asociated with postherpetic bupivacaine Transdur neuralgia 18.06.2008 For use as preparative therapy for malignancies treated Busulfan Spartaject with bone marrow transplantation. 21.04.1994

Busulfan Spartajet-Busulfan Intrathecal therapy for neoplastic meningitis 05.03.2001

Preparative therapy for pediatric patients undergoing busulfan Partaject bone marrow transplantation 25.11.2002

Busulfan Spartaject Treatment of primary brain malignancies. 07.07.1997 For use in children as a modulator of chemotherapy for Buthionine sulfoxamine the treatment of pediatric patients with neuroblastoma 05.10.2005 Use as a modulator of chemotherapy for the treatment of pediatric patients with primary malignant brain Buthionine sulfoxamine tumors 05.10.2005

Butyrylcholinesterase Treatment of post-surgical apnea. 30.09.1992

For the reduction and clearance of toxic blood levels of Butyrylcholinesterase cocaine encountered during a drug overdose. 25.03.1992

BW 12C Treatment of sickle cell disease. 23.10.1987

Treatment and prevention of angioedema caused by C1- C1 esterase inhibitor (human) esterase inhibitor deficiency. 21.08.1996

C1-esterase-inhibitor, human, Prevention and/or treatment of acute attacks of pasteurized Berinert P hereditary angioedema. 16.10.1992

Prevention of acute attacks of angioedema, including short-term prophylaxis for patients requiring dental or C1-inhibitor C1-inhibitor (human) vaother surgical procedures. 30.08.1990

C1-inhibitor C1-inhibitor (human) vaTreatment of acute attacks of angioedema. 30.08.1990 cAC10-vcMMAE (4) Treatment of Hodgkin's lymphoma. 30.01.2007

Treatment of symptomatic Paget's disease (osteitis Calcitonin salmon nasal spray Miacalcin Nasal Spraydeformans). 29.10.1990 Treatment of hyperphosphatemia in end stage renal Calcium acetate disease. 27.06.1989

Treatment of hyperphosphatemia in patients with end Calcium carbonate R & D calcium carbonastage renal disease. 06.06.1990

For use as a wash for hydrofluoric acid spills on human Calcium gluconate Calgonate skin. 20.11.1997

For use in the emergency topical treatment of hydrogen Calcium gluconate gel H-F Gel fluoride (hydrofluoric acid) burns. 21.05.1991

Emergency topical treatment of hydrogen fluoride Calcium gluconate gel 2.5% (hydrofluoric acid) burns. 10.09.1990

Calfactant Infasurf Acute respiratory distress syndrome (ARDS) 05.09.2000 canakinumab Treatment of systemic onset juvenile idiopathic arthritis 30.09.2008

Capsaicin Treatment of postherpetic neuralgia. 03.08.2005 Treatment of intermetatarsal neuroma (Morton's Neuroma) that does not respond to conservative Capsaicin treatment and requires either neurectomy or neurolysis 29.09.2006 capsaicin Treatment of erythromelalgia 23.10.2002

Capsaicin Treatment of painful HIV-associated neuropathy 02.05.2003

Carbamylglutamic acid Treatment of N-acetylglutamate synthetase deficiency. 20.01.1998 For use in the reduction of the incidence and severity of delayed graft function in patients undergoing solid carbon monoxide Covox organ transplanation. 24.06.2008 Treatment of persons with AIDS and in patients with symptomatic HIV infection and a CD4 count less than Carbovir 200/mm3. 13.12.1989

To protect the liver from ischemia-reperfusion injury cardiotrophin-1 inherent to the procedure of transplantation. 24.06.2008 carfilzomib Treatment of multiple myeloma 18.01.2008

Carmustine Treatment of intracranial malignancies. 03.07.2000

Treatment of oral drug overdosage to speed lower Cascara sagrada fluid extract bowel evacuation. 21.03.1989

Catumaxomab Removab Treatment of ovarian cancer 09.06.2006

CD4 human truncated 369 AA polypeptide Soluble T4 Treatment of acquired immunodeficiency syndrome. 21.11.1989

Treatment of graft versus host disease and/or rejection CD5-T lymphocyte immunotoxin Xomazyme-H65 in patients who have received bone marrow transplants. 27.08.1987

CDP571 Treatment of Crohn's disease. 11.12.1997

Treatment of EGFRvIII-expressing glioblastoma CDX-110 multiforme 19.11.2007

Ceftriaxone sodium Rocephin TreatmentFor use in patientsof amyotrophic receiving lateral high sclerosis dose chemotherapy 28.03.2006 Cells produced using the who are unable to generate an acceptable dose of AastromReplicelle System and SC- peripheral blood stem cells and who have a sufficient I Therapy Kit bone marrow aspirate without morphological evidence 10.07.2002 cenersen Aezea Treatment of stage IIB through IV melanoma 18.06.2008 cenersen Treatment of acute myeloid leukemia 08.05.2006 cenersen Aezea Treatment of chronic lymphocytic leukemia 27.02.2008

Treatment of scorpion envenomations requiring medical Centruroides immune F(ab)2 Alacramyn attention. 12.06.2000

Prophylactic treatment of patients exposed to inhalation cethromycin anthrax. 28.02.2007

Cetiedil citrate injection Treatment of sickle cell disease crisis. 22.12.1988 cetuximab Erbitux Treatment of pancreatic cancer 15.06.2007

Chenodeoxycholic acid Chenofalk Treatment of cerebrotendinous xanthomatosis 29.01.2004 chenodeoxycholic acid Treatment of cerebrotendinous xanthomatosis 12.02.2007

Chimeric (human-murine) G250 IgG monoclonal antibody Treatment of renal cell carcinoma. 24.07.2000 chimeric (murine-human) IgG1 mAb against IL-6 Treatment of multiple myeloma 11.10.2005 Chimeric (murine-human) IgG1k monoclonal antibody against interleukin-6 Treatment of Castleman's disease 26.05.2006

For treatment of shiga-toxin producing bacterial Chimeric monoclonal antibodies infection. 04.10.2005

Chimeric monoclonal antibody to mesothelin Treatment of pancreatic cancer 31.10.2006

Chimeric M-T412 (human-murine) IgG monoclonal anti-CD4 Treatment of multiple sclerosis. 05.06.1991 chimeric murine/human IgG1 monoclonal antibody to human interleukin-3 receptor alpha chain Treatment of acute myeloid leukemia 03.04.2009

Chimeric, humanized monoclonal Prophylaxis of Staphylococcus epidermidis sepsis in antibody to staphylococcus low birth weight (1500 grams or less) infants. 03.08.2000 For use in the amelioration of oral mucositis associated Chlorhexidine gluconate with cytoreductive therapy used in conditioning patients mouthrinse Peridex for bone marrow transplantation therapy. 18.08.1986 chlorotoxin Treatment of stage IIb, IIc, III & IV melanoma 02.12.2008

Chlorotoxin Treatment of malignant glioma 18.12.2007 cholest-4-en-3-one, oxime Treatment of spinal muscular atrophy. 17.02.2009 cholic acid (3 alpha, 7 alpha, 12 Treatment of inborn errors of cholesterol and bile acid alpha trihydroxy 5-beta cholanolic Falkochol synthesis and metabolism 18.07.2003 Prevention and/or treatment of choline deficiency in Choline chloride IntraChol patients on long-term parenteral nutrition 20.07.2006 Treatment of choline deficiency, specifically the choline deficiency, hepatic steatosis, and cholestasis, Choline chloride Intrachol associated with long-term parenteral nutrition. 10.02.1994

Chondrocyte-alginate gel For use in correcting vesicoureteral reflux in the suspension pediatric population. 01.12.1997

Chondroitinase Treatment of patients undergoing vitrectomy. 09.02.1995 cicletanine hydrochloride Treatment for pulmonary arterial hypertension. 24.06.2008 cilengitide Treatment of malignant glioma 27.05.2005

Ciliary neurotrophic factor Treatment of motoramyotrophic neuron lateral disease sclerosis. (including 30.01.1992 Ciliary neurotrophic factor, amyotrophic lateral sclerosis, progressive muscular recombinant human atrophy, progressive bulbar palsy, and primary lateral 08.05.1992

Ciliary neurotrophic factor, recombinant human Treatment of spinal muscular atrophies. 02.04.1992

Cisplatin in liposomal formulation SLIT Cisplatin for inhalaTreatment of osteogenic sarcoma metastatic to the lung 20.03.2007

Cisplatin/epinephrine IntraDose Treatment of metastatic malignant melanoma. 07.09.2000

Treatment of squamous cell carcinoma of the head and Cisplatin/epinephrine IntraDose neck. 03.04.2000

Treatment of postherpetic neuralgia of the trigeminal Civamide Zucapsaicin nerve 09.12.2002

Cladribine Leustatin Treatment of acute myeloid leukemia. 20.07.1990

Cladribine Leustatin Injection Treatment of chronic lymphocytic leukemia. 31.12.1990 Treatment of the chronic progressive form of multiple Cladribine Mylinax sclerosis. 19.04.1994 Cladribine Leustatin Injection Treatment of non-Hodgkin's lymphoma. 19.04.1993 Treatment of cerebral vasospasm following Clazosentan Erajet subarachnoid hemorrhage 16.02.2006

Prevention of Pneumocystis carinii pneumonia in AIDS Clindamycin Cleocin patients. 28.10.1988

Treatment of Pneumocystis carinii pneumonia Clindamycin Cleocin associated with AIDS patients. 28.10.1988

Clindamycin hydrochloride Treatment of sarcoidosis 09.08.2006

clobazam Treatment of Lennox-Gastaut Syndrome. 18.12.2007 clofarabine Clofarex Treatment of acute myelogenous leukemia 14.03.2002

Clonazepam Klonopin Treatment of hyperekplexia (startle disease). 04.08.1994

Clonazepam Intranasal Spray Treatment of recurrent acute repetitive seizures 19.12.2007

Treatment of advanced (involutional or residual stage) Clostridial collagenase Dupuytren's disease. 23.05.1996

Clotrimazole Topical treatment of children and adults with pouchitis 14.06.2005

Clotrimazole Treatment of Huntington's disease 13.03.2006

Clotrimazole Treatment of sickle cell disease. 24.04.1995 c-myb antisense oligodeoxynucleotide Treatment of chronic myelogenous leukemia 22.02.2005 Coagulation factor VIIa Prevention of bleeding episodes in Glanzmann's (recombinant) NovoSeven thrombasthenia 18.06.2004

Coagulation factor VIIa Treatment of bleeding episodes in Glanzmann's (Recombinant) NovoSeven thrombasthenia 18.06.2004

Coagulation Factor VIIa Treatment of bleeding in patients experiencing (Recombinant) NovoSeven intracranial hemorrhage. 03.10.2006 cobiprostone Treatment of cystic fibrosis 14.11.2002 coccidioidin SD Skin Test Antigen For the diagnosis of Coccidioidomycosis. 19.12.2007

Coenzyme Q10 Treatment of Huntington's disease 05.03.2001

Colchicine Treatment of familial Mediterranean fever 25.09.2007

Colchicine Treatment of Behcet's Syndrome 25.09.2007

For arresting the progression of neurologic disability Colchicine caused by chronic progressive multiple sclerosis. 09.12.1985

Collagenase (lyophilized) for injection Plaquase Treatment of Peyronie's disease. 12.03.1996

Combretastatin A4 phosphate Treatment of anaplasticovarian cancer thyroid cancer, medullary 08.05.2006 thyroid cancer, and stage IV papillary or follicular Combretastatin A4 Phosphate thyroid cancer 23.07.2003 conjugate of human transferrin and a mutant diphtheria toxin Treatment of malignant tumors of the central nervous (CRM 107) TransMID system 03.12.2001

Treatment of steatorrhea in patients with short bowel conjugated bile acids COBARTin syndrome 18.07.2003

Intrathecal treatment of neuropathic pain associated Contulakin-G with spinal cord injury 07.07.2005 Cordycepin Treatment of TdT-positive acute lymphocytic leukemia 05.07.2007

Corticotropin-releasing factor, human Xerecept Treatment of peritumoral brain edema. 06.04.1998

Coumarin Onkolox Treatment of renal cell carcinoma. 22.12.1994

Treatment of stage II (T4), stage III, and stage IV Coxsackievirus A21 Cavatak melanoma 15.12.2005

Creatine Creapure Treatment of Huntington's disease 11.10.2005 creatine Creapure Treatment of amyotrophic lateral sclerosis 12.02.2002

Treatment of soil transmitted helminth infection Cry5B strongyloidiasis 05.09.2008

Cryptosporidium hyperimmune Treatment of diarrhea in AIDS patients caused by bovine colostrum IgG concentrate infection with Cryptosporidium parvum. 30.12.1991 cultured, partially T-Cell depleted, As a therapy for primary immune deficiency resulting allogenic thymic tissue for from athymia associated with complete DiGeorge transplantation Syndrome 15.08.2003 Treatment of neonates and infants undergoing cardiopulmonary bypass during surgical repair of CY-1503 Cylexin congenital heart lesions. 18.07.1997 Treatment of post-ischemic pulmonary reperfusion edema following surgical treatment for chronic CY-1503 Cylexin thromboembolic pulmonary hypertension. 22.12.1993

Treatment of chronic active hepatitis B infection in HLA- CY-1899 A2 positive patients. 16.03.1994 Cyclo {{(E,Z)-(2S,3R,4R)-3- hydroxy-4-methyl-2- Treatment and chronic control of non-infectious (methylamino)nona-6,8-dienoyl}-L- posterior, intermediate and pan-uveitis 20.12.2006 Treatment of amyotrophic lateral sclerosis and its Cyclosporin A Mitogard variants 29.10.2004 cyclosporine Prophylaxis of graft-versus-host disease 17.02.2009 cyclosporine Treatment of graft-versus-host disease 17.02.2009

Prophylaxis of organ rejection in patients receiving Cyclosporine allogeneic lung transplant Kristin Miller, CSO, HFD-590. 25.11.2003

Treatment of acute rejection in patients requiring Cyclosporine Pluminiq allogenic lung transplants 25.11.2003

Cyclosporine 2% ophthalmic Treatment of patients at high risk of graft rejection ointment following penetrating keratoplasty. 01.08.1991 For use in corneal melting syndromes of known or Cyclosporine 2% ophthalmic presumed immunologic etiopathogenesis, including ointment Mooren's ulcer. 01.08.1991

Cyclosporine A Treatment of vernal keratoconjunctivitis 04.05.2007 cyclosporine A Prevention of corneal graft rejection 30.09.2008 cyclosporine A NOVA22007 Treatment of herpes simplex virus stromal keratitis 09.04.2008

For the prevention of acute rejection in cornea Cyclosporine A implant transplant patients 08.01.2007 Cyclosporine in combination with omega-3 polyunsaturated fatty acids Prevention of solid organ graft rejection. 06.12.2000 Treatment of severe keratoconjunctivitis sicca Cyclosporine ophthalmic Optimmune associated with Sjogren's syndrome. 09.11.1988

Cyproterone acetate Androcur Treatment of severe hirsutism. 26.10.1984 For use in conjunction with melphalen for the treatment of malignant melanoma, AJCC stages IIB, IIC, III and Cys-His-Ala-Val-Cys IV 14.02.2008

Treatment of neuronal ceroid lipofuscinoses (Batten cysteamine disease) 06.08.2008 cysteamine Treatment of Huntington's disease 09.05.2008 Cysteamine Treatment of nephropathic cystinosis. 01.05.1986 Treatment of corneal cystine crystal accumulation in Cysteamine hydrochloride cystinosis patients. 19.08.1997

Cystic fibrosis gene therapy Treatment of cystic fibrosis. 30.06.1992

Cystic fibrosis Tr gene therapy (recombinant adenovirus) AdGVCFTR.10 Treatment of cystic fibrosis. 09.03.1995 For cystic fibrosis transmembrane conductance Cystic fibrosis transmembrane regulator protein replacement therapy in cystic fibrosis conductance regulator patients. 14.01.1992 Cystic fibrosis transmembrane conductance regulator gene Treatment of cystic fibrosis. 08.01.1993 cytarabine liposome DepoCyt Treatment of gliomas 30.01.2007

Cytarabine:daunorubicin liposome injection ForTreatment use in preventionof acute myeloid of clinically leukemia significant CMV 22.08.2008 Cytomegalovirus DNA Vaccine viremia, CMV disease and associated complications in w/Copolymer/Benzalkonium at-risk hematopoietic cell transplant and solid organ Chloride Preventiontransplant populations of clinically significant cytomegalovirus 23.09.2006 Cytomegalovirus DNA vaccine (CMV) viremia, CMV disease and asociated with plasmids expressing pp65 complications in at-risk hematopoietic cell transplant and gB genes and solid transplant populations 03.06.2005 For use in conjunction with ganciclovir sodium for the Cytomegalovirus immune globulin treatment of cytomegalovirus pneumonia in bone intravenous (human) marrow transplant patients. 28.01.1991

Dantrolene sodium Dantrium Treatment of the neuroleptic malignant syndrome. 14.12.1987 Prophylaxis of toxoplasmosis in severely immunocompromised patients with CD4 counts below Dapsone 100. 07.11.1994

For the combination treatment of Pneumocystis carinii Dapsone USP Dapsone pneumonia in conjunction with trimethoprim. 08.01.1992

Dapsone USP Dapsone Prophylaxis for Pneumocystis carinii pneumonia. 24.12.1991 Daunorubicin liposomal Treatment of acute myeloid leukemia 05.09.2008

DEAE-rebeccamycin Treatment of bile duct tumors 01.03.2004

Debridement of acute, deep dermal burns in debrase Debridase hospitalized patients 20.08.2003

Decitabine Dacogen Treatment of acute myeloid leukemia 04.08.2006 decitabine Treatment of sickle cell anemia 09.09.2002

Decitabine Treatment of chronic myelogenous leukemia. 08.03.1999 deferiprone Treatment of Friedreich's ataxia. 31.07.2008

Treatment of iron overload in patients with hematologic deferiprone Ferriprox disorders requiring chronic transfusion therapy 12.12.2001 deferoxamine-starch conjugate Treatment of acute iron poisoning. 28.01.2005

defibrotide For the prevention of hepatic veno-occlusive disease. 08.01.2007

Defibrotide For the treatment of hepatic veno-occlusive disease 21.05.2003

Defibrotide Treatment of thrombotic thrombocytopenic purpura. 05.07.1985 Treatment of systemic lupus erythematosus (SLE) and the reduction in the use of steroids in steroid-dependent Dehydroepiandrosterone SLE patients. 13.07.1994

Replacement therapy in individuals with adrenal Dehydroepiandrosterone (DHEA) Fidelin insufficiency 19.08.2003

Dehydroepiandrosterone sulfate sodium Treatment of serious burns requiring hospitalization. 29.01.1997 To accelerate the re-epithelialization of donor sites in Dehydroepiandrosterone sulfate those hospitalized burn patients who must undergo sodium autologous skin grafting. 28.01.1997

Deslorelin Somagard 05.11.1987

Desmoglein 3 synthetic peptide (PI-0824) Treatment of pemphigus vulgaris 26.10.2004

For use in posterior segment drug delivery system in Dexamethasone Posurdex the treatment of idiopathic intermediate uveitis. 11.09.1998

dexamethasone phosphate ForTreatment the attenuation of corneal or graft amelioration rejection. of the long-term 02.12.2008 neurological sequelae associated with moderate and dexanabinol severe traumatic brain injury 11.08.2004 dextran 1 Treatment of cystic fibrosis 21.03.2003

Treatment of recurrent corneal erosion unresponsive to Dextran 70 Dehydrex conventional therapy. 05.03.1990

Dextran and deferoxamine Bio-Rescue Treatment of acute iron poisoning. 08.03.1991

Dextran sulfate (inhaled, aerosolized) Uendex For use as an adjunct to the treatment of cystic fibrosis. 05.10.1990

Dextran sulfate sodium Treatment of aquired immunodeficiency syndrome. 19.11.1987

DHA-paclitaxel Taxoprexin Treatment of pancreatic cancer 25.09.2001

Treatment of adenocarcinoma of the stomach or lower DHA-paclitaxel Taxoprexin esophagus 01.05.2003

DHA-paclitaxel Taxoprexin Treatment of metastatic malignant melanoma 10.10.2002 For use as a nutritional supplement for the treatment of Dianeal peritoneal dialysis solution malnourishment in patients undergoing continuous with 1.1% amino acids Nutrineal (Peritoneal Diambulatory peritoneal dialysis. 11.06.1992 Treatment of primary brain malignancies (grade III and Diaziquone IV astrocytomas). 10.11.1983

Dideoxyinosine Treatment of acquired immunodeficiency syndrome. 22.06.1988

Diethyldithiocarbamate Imuthiol Treatment of AIDS. 03.04.1986 diethylenetriaminepentaacetate internal contamination with plutonium, americium or (DPTA) curium to increase the rates of elimination. 14.04.2004

Diethylnorspermine (DENSPM) Treatment for hepatocellular carcinoma 25.05.2004 diferuloylmethane Treatment of cystic fibrosis 13.06.2003

Treatment of endogenous and traumatic anterior uveitis difluprednate Durezol and panuveitis. 30.09.2008

Digitoxin Treatment of cystic fibrosis 27.05.2005 digitoxin Treatment of soft tissue sarcomas 18.10.2001

digitoxin Treatment of life-threateningovarian cancer acute cardiac glycoside 02.11.2001 intoxication manifested by conduction disorders, ectopic ventricular activity and (in some cases) Digoxin immune fab(ovine) Digidote hyperkalemia. 11.03.1985 Treatment of uncomplicated malaria caused by dihydroartemisinin and "Plasmodium falciparum," Plasmodium vivax," piperaquine Eurartesim Plasmodium malariae," or "Plasmodium ovale." 08.01.2007

Treatment of weight loss in AIDS patients with HIV- Dihydrotestosterone Androgel -DHT associated wasting. 05.02.1996

For use in combination with antimicrobial drugs for the dimethyl sulfoxide Treatmenttreatment of of drug increased resistant intracranial tuberculosis pressure in patients 09.05.2008 with severe, closed-head injury, also known as traumatic brain coma, for whom no other effective Dimethyl sulfoxide treatment is available. 22.11.1994 Dimethyl sulfoxide Treatment of cutaneous manifestations of scleroderma. 06.06.1986 Treatment of palmar-plantar erythrodysethesia Dimethylsulfoxide syndrome. 06.04.1998

Topical treatment for the prevention of soft tissue injury Dimethylsulfoxide following extravastion of cytotoxic drugs. 15.04.1997

Dipalmitoylphosphatidylcholine Prevention and treatment of neonatal respiratory /phosphatidylglycerol ALEC distress syndrome. 28.07.1988

Treatment of chronic severe forms of alopecia areata diphenylcyclopenone (Alopecia Totalis [AT]/Alopecia Universalis [AU]) 13.06.2003 Disaccharide tripeptide glycerol Treatment of pulmonary and hepatic metastases in dipalmitoyl Immther patients with colorectal adenocarcinoma. 01.03.1990

Disodium clodronate Treatment of hypercalcemia of malignancy. 16.06.1993

Treatment of increased bone resorption due to Disodium clodronate tetrahydrate Bonefos malignancy. 05.03.1990

Treatment of hepatic intoxication by Amanita phalloides Disodium silibinin dihemisuccinate Legalon (mushroom poisoning). 10.07.1986

D-mannitol and L-proline Prodarsan(r) Treatment of Cockayne syndrome 20.04.2009

Therapeutic management of patients with lung disease DMP 777 attributable to cystic fibrosis. 04.06.1996

DNA plasmid vector expressing human IL-12 gene Treatment of ovarian cancer. 04.04.2005 DNA-lipid complex (DMRIE/DOPE)/plasmid vector (VCL-1102, Vical) expressing Leuvectin Treatment of renal cell carcinoma. 28.04.2000

DNP-Modified autologous tumor vaccine O-Vax Adjuvant therapy for the treatment of ovarian cancer 21.09.2000 docosahexanoic acid-paclitaxel Taxoprexin Treatment of hormone-refractory prostate cancer. 05.03.2001 Treatment of bronchopulmonary infection in patients with cystic fibrosis who are colonized with Doripenem Pseudomonas aeruginosa or Burkholderia cepacia. 16.07.2004

Dovitinib Treatment of multiple myeloma 03.10.2006 Doxorubicin HCl with pluronic L-61 and pluronic F-127 Treatment of esophageal carcinoma 07.10.2005 doxorubicin PIHCA nanoparticles Doxorubicin TransdrugTreatment of hepatocellular carcinoma 14.03.2005 doxorubicin with pluronics F-127 and L-61 Treatment of gastric cancer 20.02.2008

D-peptide of the sequence AKRHHGYKRKFH - NH2 PulmaDex Treatment of cystic fibrosis 23.10.2002

D-Phe-Cys-Tyr-D-Trp-Lys-Cys-Thr- Nh2 (disulfide bridge: 2-6) acetate Treatment of neurogenicmelanoma, symptomaticstages IIb through orthostatic IV 19.03.2009 hypotension in patients with primary autonomic failure, dopamine-beta-hydroxylase deficiency, and nondiabetic droxidopa autonomic neuropathy. 17.01.2007

Duramycin Treatment of cystic fibrosis. 11.12.1997

Treatment of hereditary motor and sensory neuropathy Dynamine type I (Charcot-Marie-Tooth disease). 16.10.1991

Dynamine Treatment of Lambert Eaton myasthenic syndrome. 05.02.1990 ecallantide Kalbitor Treatment of angioedema 04.02.2003 eculizumab Soliris(r) Treatment of atypical hemolytic uremic syndrome 29.04.2009

Treatment of idiopathic membranous glomerular eculizumab nephropathy 05.03.2001

Eculizumab Treatment of dermatomyositis 21.09.2000 Treatment of somatostatin receptor-positive Edotreotide OctreoTher neuroendocrine gastroenteropancreatic tumors 28.07.2005 Adjunct to whole brain radiation therapy for the treatment of brain metastases in patients with breast efaproxiral cancer 28.07.2004

Eflornithine Treatment of anaplastic glioma 29.09.2006

Treatment of Pneumocystis carinii pneumonia in AIDS Eflornithine HCl Ornidyl patients. 18.04.1986

Elcatonin Intrathecal treatment of intractable pain. 25.09.1995

Enadoline hydrochloride Treatment of severe head injury. 28.01.1997

Encapsulated porcine islet Treatment of type I diabetic patients who are already on preparation BetaRx immunosuppression. 05.07.1995 eniluracil Treatment of hepatocellular carcinoma 15.12.2005

For use in organ transplant patients to diminish the Enisoprost nephrotoxicity induced by cyclosporine. 20.10.1989

For use with cyclosporine in organ transplant recipients Enisoprost to reduce acute transplant rejection. 20.10.1989

Enteric-coated cysteamine Treatment of cystinosis 24.10.2006 enzastaurin Treatment of diffuse large B-cell lymphoma 04.03.2009

Enzastaurin Treatment of glioblastoma multiforme 19.09.2005 For acceleration of corneal epithelial regeneration and the healing of stromal tissue in the condition of non- Epidermal growth factor (human) healing corneal defects. 05.10.1987 For promotion of cutaneous wound healing in extreme Epidermal growth factor (human) burn treatment protocols. 06.03.1985

Epoetin alfa Treatment of myelodysplastic syndrome. 20.12.1993

Treatment of anemia associated with end stage renal Epoetin alpha Procrit disease. 27.08.1987

Epoetin alpha Procrit Treatment of anemia of prematurity in preterm infants. 21.07.1988

Treatment of HIV associated anemia related to HIV Epoetin alpha Procrit infection or HIV treatment. 07.03.1989

Treatment of anemia associated with end stage renal Epoetin beta Marogen disease. 22.10.1987 Replacement of heparin in patients requiring hemodialysis and who are at increased risk of Epoprostenol Flolan hemorrhage. 29.03.1984 Replacement of heparin in patients requiring hemodialysis and who are at increased risk of Epoprostenol Cycloprostin hemorrhage. 29.10.1984 epratuzumab Treatment of acute lymphoblastic leukemia 30.09.2008 epratuzumab LymphoCIDE Treatment of non-Hodgkin's lymphoma. 13.07.1998

Eprodisate Fibrillex Treatment of secondary amyloidosis 06.04.1999 Prevention and treatment of EBV-post transplant Epstein Barr Virus specific lymphoproliferative disease after hematopoietic stem cytotoxic T lymphocytes cell transplant or solid organ transplant. 27.12.2006

Erlotinib Hydrochloride Tarceva Treatment of malignant gliomas 18.07.2003

Erwinia L-asparaginase Erwinase TreatmentFor use as ofan acute alternative lymphocytic to E. coli leukemia. asparaginase in 30.07.1986 those situations where repeat courses of asparaginase therapy for acute lymphoblastic leukemia are required Erwinia L-asparaginase or where allergic reactions force the discontinuance of 25.01.1985 Erythropoietin (human, Treatment of anemia associated with end stage renal recombinant) disease. 19.11.1987

Erythropoietin (recombinant Treatment of anemia associated with end stage renal human) disease. 19.08.1987

Estrogen replacement therapy in females with Turner Estradiol Gel EstroGel (r) syndrome 31.10.2006

Etanercept Enbrel Treatment of Wegener's granulomatosis. 06.04.1999

Ethanol gel Treatment of congenital lymphatic malformations 13.03.2006

Ethanol gel Treatment of congenital venous malformations 29.03.2006

Ethinyl Estradiol, USP Treatment of Turner's syndrome. 22.06.1988

Use as a chemoprotective agent for cisplatin and Ethiofos cyclophosphamide in the treatment of ovarian cancer. 01.08.1989

Ethyl eicosapentaenoate Treatment of Huntington's disease. 06.04.2000

Prevention of degenerative metabolic bone disease occurring in patients who require long term (6 months Etidronate disodium Didronel IV infusion or greater) total parenteral nutrition. 02.05.1991 Treatment of degenerative metabolic bone disease occurring in patients who require long term (6 months Etidronate disodium Didronel IV Infusion or greater) total parenteral nutrition. 02.05.1991

Etiocholanedione Treatment of Prader-Willi syndrome. 07.05.1996

Etiocholanedione Treatment of aplastic anemia. 03.11.1995

Treatment of gastroenteropancreatic neuroendocrine everolimus tumors 14.02.2008 Ex vivo cultured adult human mesenchymal stem cells Prochymal Treatment of acute graft versus host disease 14.12.2005 For the suppression and control of colonic adenomatous polyps in the inherited disease Exisulind adenomatous polyposis coli. 14.02.1994

Factor XIII [A2] homodimer, recombinant DNA origin Treatment of congenital FXIII deficiency 21.05.2003

Factor XIII [A2} homodimer, For the prophylaxis of bleeding associated with recombinant DNA origin congential FXIII deficiency 06.11.2003 factor XIII concentrate (human), pasteurized Fibrogammin P Treatment of congenital factor XIII deficiency. 16.01.1985

Factor XIII, recombinant Treatment of congenital factor XIII deficiency. 22.04.1993

Fampridine Neurelan Relief of symptoms of multiple sclerosis. 02.06.1987

Fampridine Neurelan Treatment of chronic, incomplete spinal cord injury. 02.06.1997

Fenobam hydrochloride Treatment of fragile X syndrome 20.11.2006 fenretinide Treatment of Ewing's sarcoma family of tumors. 01.02.2007

Fenretinide Treatment of neuroblastoma 05.10.2005 ferric hexacyanoferrate (II) contamination with radioactive or non-radioactive "Prussian Blue" cesium or thallium 26.06.2003

FIAU Adjunctive treatment of chronic active hepatitis B. 24.07.1992

For the control of bleeding and prophylactic treatment Fibrinogen (human) of patients deficient in fibrinogen. 23.08.1995 Treatment of non-healing corneal ulcers or epithelial Fibronectin (human plasma defects which have been unresponsive to conventional derived) therapy and the underlying cause has been eliminated. 05.09.1988 Treatment of non-healing corneal ulcers or epithelial defects which are unresponsive to conventional therapy and for which any infectious cause of the defect has Fibronectin (plasma derived) been eliminated. 05.12.1988

Filgrastim Neupogen Treatment of myelodysplastic syndrome. 30.08.1990 Treatment of patients with AIDS who, in addition, are afflicted with cytomegalovirus retinitis and are being Filgrastim Neupogen treated with ganciclovir. 03.09.1991

Floxuridine, FUDR Intraperitoneal treatment of gastric cancer. 22.12.2004

Treatment and management of patients with non- Fludarabine phosphate Fludara Hodgkins lymphoma. 18.04.1989 Treatment of hyperbilirubinemia in newborn infants Flumecinol Zixoryn unresponsive to phototherapy. 15.01.1985

Flunarizine Sibelium Treatment of alternating hemiplegia. 06.01.1986

For use in combination with leucovorin for therapy of Fluorouracil Adrucil metastatic adenocarcinoma of the colon and rectum. 06.02.1989

For use in combination with interferon alpha-2a, recombinant, for the treatment of esophageal Fluorouracil carcinoma. 27.10.1989 For use in combination with interferon alpha-2a, recombinant, for the treatment of advanced colorectal Fluorouracil carcinoma. 18.04.1990

Fluorouracil Treatment of glioblastoma multiforme. 29.06.2000

Fluoxetine Prozac Treatment of autism. 30.04.1999

Treatment of body dysmorphic disorder in children and Fluoxetine Prozac adolescents 14.04.2004 Treatment of pulmonary infections associated with fosfomycin/tobramycin cystic fibrosis. 28.11.2008

Treatment of painful vaso-occlusive episodes Fructose-1,6-diphosphate Cordox associated with sickle cell disease. 29.05.1998 Full Phosphorothioate Antisense Oligonucleotide against EWS-Fli-1 nanoparticles Treatment of Ewing's sarcoma 22.09.2008

Fully Human Anti-MCP-1/CCL2 Monoclonal Antibody Treatment of idiopathic pulmonary fibrosis. 08.11.2007 Fusion protein consisting of human immunoglobim G1 Treatment of X-linked hypohidrotic ectodermal constant region Fc region fused to dysplasia 11.01.2006

G17DT Immunogen Treatment of gastric cancer 18.07.2002

G17DT Immunogen Treatment of adenocarcinoma of the pancreas 10.07.2002

Gabapentin Neurontin Treatment of amyotrophic lateral sclerosis. 05.07.1995 Treatment of narcolepsy and the auxiliary symptoms of cataplexy, sleep paralysis, hypnagogic hallucinations Gamma hydroxybutyrate and automatic behavior. 03.12.1987 Treatment of narcolepsy and the auxiliary symptoms of cataplexy, sleep paralysis, hypnagogic hallucinations, Gamma-hydroxybutyric acid and automatic behavior. 22.01.1985

Gammalinolenic acid Treatment of juvenile rheumatoid arthritis. 27.07.1994

Ganaxolone Treatment of infantile spasms. 25.05.1994 Treatment of acute herpetic keratitis (dendritic and Ganciclovir Virgan geographic ulcers) 22.03.2007

Treatment of severe human cytomegalovirus infections Gancyclovir in specific immunosuppressed patient populations. 07.06.1985

Gangliosides as sodium salts Cronassial Treatment of retinitis pigmentosa. 17.11.1988

Gavilimomab Acute graft-versus-host disease (aGVHD) 20.11.2000 gene encoding chimeric CD40 ligand Treatment of chronic lymphocytic leukemia 04.02.2009 Gene plasmid hVEGF165 driven by human cytomegalovirus, and Prevention of complications due to neointimal [2,3-bis(oleoyl)propyl]trimethyl Trinam hyperplasia disease in certain vascular anastomoses. 24.10.2000 genetically engineered herpes simplex virus (G207) Tretament of malignant glioma 29.04.2002

Geneticin Treatment of amoebiasis. 06.06.2005

Gentamicin impregnated PMMA Treatment of chronic osteomyelitis of post-traumatic, beads on surgical wire Septopal postoperative, or hematogenous origin. 31.01.1991

Treatment of disseminated Mycobacterium avium- Gentamicin liposome injection Maitec intracellulare infection. 10.07.1990 glatiramer acetate Copaxone Treatment of amyothrophic lateral sclerosis (ALS). 14.11.2007

Glatiramer acetate for injection Copaxone Treatment of primary-progressive multiple sclerosis 05.06.2001 glucarpidase Voraxaze Treatment of patients at risk of methotrexate toxicity 19.08.2003 glufosfamide For treatment of pancreatic cancer. 18.09.2006 Prevention of delayed graft function after solid organ transplantation Glycafilin 22.08.2008

To decrease intracranial hypertension and/or alleviate cerebral edema in patients who may benefit from Glyceol osmotherapy. 22.02.1990

Glyceryl tri (4-phenylbutyrate) Treatment of spinal muscular atrophy 24.05.2005

Maintenance treatment of patients with deficiencies in glyceryl tri (4-phenylbutyrate) enzymes of the urea cycle 27.04.2009 Glyceryl trioleate and glyceryl trierucate Treatment of adrenoleukodystrophy. 14.02.1995

Treatment of pathologic (chronic moderate to severe) Glycopyrrolate drooling in pediatric patients 09.06.2006

Treatment of vaso-occlusive crisis in patients with GMI-1070 sickle cell disease. 17.02.2009

GNE Lipoplex Treatment of hereditary inclusion body myopathy-2 13.11.2008

Golimumab Treatment of chronic sarcoidosis 02.11.2004

Gossypol Treatment of cancer of the adrenal cortex. 22.10.1990

Gp100 adenoviral gene therapy Treatment of metastatic melanoma. 25.03.1997 granulocyte macrophage colony stimuling factor Treatment of cystic fibrosis 27.08.2008

Granulocyte macrophage-colony Treatment of severe thermal injuries in patients with stimulating factor Leucomax greater than 40% full or partial thickness burns. 06.06.1989 Granulocyte macrophage-colony Treatment of chronic lymphocytic leukemia to increase stimulating factor Leucomax granulocyte count. 04.05.1990 Granulocyte macrophage-colony stimulating factor Leucomax Treatment of myelodysplastic syndrome. 07.08.1989

Granulocyte macrophage-colony Treatment of neutropenia associated with bone marrow stimulating factor Leucomax transplants. 12.12.1989 Granulocyte macrophage-colony stimulating factor Leucomax Treatment of neutropenia due to hairy cell leukemia. 03.05.1990

Group B streptococcus immune Treatment of neonates for disseminated group B globulin streptococcal infection. 08.05.1990 For the long-term treatment of children who have growth failure due to a lack of adequate endogenous Growth hormone releasing factor growth hormone secretion. 07.08.1989

Treatment of moderate to severe reflex sympathetic Guanethidine monosulfate Ismelin dystrophy and causalgia. 06.01.1986 Guanfacine Tenex Treatment of fragile X syndrome. 05.08.1999

Gusperimus Spanidin Treatment of acute renal graft rejection episodes. 27.06.1996

Halofuginone Stenorol Treatment of systemic sclerosis. 07.02.2000 heat killed Mycobacterium w immunomodulator CADI Mw Active tuberculosis 03.09.2004 heat killed mycobacterium w Adjuvant to multi-drug therapy in the management of immunomodulator CADI Mw multibacillary leprosy 21.11.2002

Heme arginate Normosang Treatment of symptomatic stage of acute porphyria. 10.03.1988

Heme arginate Normosang Treatment of myelodysplastic syndromes. 01.03.1994

Hemin and zinc mesoporphyrin Hemex Treatment of acute porphyric syndromes. 20.12.1993

Hemoximer (pyridoxalated hemoglobin polyoxyethylene) Treatment of cardiogenic shock 18.12.2007

Heparin Treatment of cystic fibrosis 03.11.2005

Heparin sodium Treatment of cystic fibrosis 29.06.2006 Prevention and treatment of necrotizing enterocolitis Heparin-binding epidermal growth (NEC) in preterm infants with birth weight less than factor-like growth factor 1,500 grams 18.09.2006

Hepatitis B immune globulin Prophylaxis against hepatitis B virus reinfection in liver intravenous (human) Nabi-HB transplant patients. 08.03.1995

Hepatitis C virus immune globulin Prophylaxis of hepatitis C infection in liver transplant (human) Civacir(tm) recipients. 14.11.2002 For the prevention of hepatitis B virus (HBV) reinfection HepeX-B in patients who have received a liver transplantation 15.07.2003

Herpes simplex virus gene Treatment of primary and metastatic brain tumors. 16.10.1992

For use as an adjunct to cytokine therapy in the Histamine Maxamine treatment of malignant melanoma. 01.02.2000

Adjunct to cytokine therapy in the treatment of acute Histamine Ceplene myeloid leukemia. 15.12.1999

Treatment of acute intermittent porphyria, hereditary Histrelin coproporphyria, and variegate porphyria. 03.05.1991

HIV neutralizing antibodies Immupath Treatment of acquired immunodeficiency syndrome. 24.03.1992

HLA-B7/Beta2M DNA Lipid Treatment of invasive and metastatic melanoma (DMRIE/DOPE) Complex Allovectin-7 (Stages II, III, and IV). 30.09.1999 homoharringtonine Treatment for chronic myelogenous leukemia 08.02.2002

HPA-23 Treatment of acquired immunodeficiency syndrome. 17.07.1985

HPV-16 cancer therapeutic trojan Treatment of HPV-16 expressing head and neck peptide vaccine squamous cell carcinoma. 12.01.2009

Hsp E7 Treatment of recurrent respiratory papillomatosis (RRP) 19.03.2001

Hu1D10, humanized monoclonal For use in the treatment of 1D10+ B cell non-Hodgkin's antibody Remitogen lymphoma 28.11.2001

Human acid precursor alpha- glucosidase, recombinant Treatment of patientsglycogen with storage invasive disease (malignant) type II. brain 10.09.1996 Human alpha 2,6 sialyltransferase and central nervous system tumors lacking alpha 2,6 adenoviral gene therapy sialyltransferase. 04.04.2005

Human anti-CD30 monoclonal antibody Treatment of Hodgkin's disease 27.09.2004 human anti-CD4 monoclonal antibody HuMax-CD4 Treatment of mycosis fungoides 13.08.2004 human anti-cellular adhesion molecule-1 monoclonal antibody Treatment of multiple myeloma 29.07.2008

Human anti-integrin receptor av monoclonal antibody Treatment of patients with angiosarcoma 05.05.2005 human anti-integrin receptor Treatment of patients with high-risk stage II, stage III, avb3/avb5 monoclonal antibody and stage IV malignant melanoma 01.12.2004 human anti-transforming growth factor beta 1 monoclonal antibody Treatment of systemic sclerosis 11.01.2002 human anti-transforming growth factor-B1,2,3 Treatment of idiopathic pulmonary fibrosis 09.07.2004 Human autologous bone-forming cell derived from bone marrow stem cells Treatment of osteonecrosis 24.03.2008 human coagulation factor XI Hemoleven Treatment of severe congential Factor XI deficiency. 08.11.2007

Prevention of congenital cytomegalovirus (CMV) Human cytomegalovirus infection following primary CMV infection in pregnant immunoglobulin women 20.12.2006

Human factor X Treatment of hereditary factor X deficiency 08.11.2007 Treatment of gastrointestinal disturbances (to include constipation, diarrhea, and abdominal pain) associated human gammaglobulin with regression-onset autism in pediatric patients. 16.09.2002 human gammaglobulin Treatment of idiopathic inflammatory myopathies 14.11.2003 human gammaglobulin Treatment for juvenile rheumatoid arthritis 25.05.2001

Human IgM monoclonal antibody Prophylaxis of cytomegalovirus infections in bone (C-58) To CMV Centovir marrow transplant patients. 07.08.1989 Human IgM monoclonal antibody Treatment of cytomegalovirus infections in allogenic (C-58) To CMV Centovir bone marrow transplant patients. 07.08.1989

Human immune globulin Xepol Treatment of post-polio syndrome 29.03.2006

Human immunodeficiency virus immune globulin Treatment of AIDS. 21.11.1989

Human immunodeficiency virus Treatment of HIV-infected pregnant women and infants immune globulin of HIV-infected mothers. 25.03.1992

Human immunodeficiency virus immune globulin Hivig Treatment of HIV-infected pediatric patients. 04.01.1995 Human immunoglobin anti-CD30 monoclonal antibody Treatment of CD30+ T-cell lymphoma 10.01.2006 Human immunoglobulin (IgG1k)antiCTLA-4 monoclonal Treatment of high risk Stage II, Stage III, and Stage IV antibody melanoma 03.06.2004 human leukocyte-derived cytokine Neoadjuvant therapy in patients with squamous cell mixture carcinoma of the head and neck 07.07.2005 Human monoclonal antibody against platelet-derived growth To slow the progression of IgA nephropathy and delay factor D kidney failure in patients affected by the disease. 02.11.2004 Human monoclonal antibody directed against serotype 011 Treatment of hospital acquired pneumonia caused by Pseudomonas aeruginosa Aerumab 11 serotype 011 positive Pseudomonas aeruginosa 18.09.2006 Human monoclonal antibody of the Ig1/k-isotype against human interleukin-1 beta Treatment of cryopyrin-associated periodic syndromes 18.12.2007

Human monoclonal antibody targeting CC-chemokine ligand 2 Treatment of vonpancreatic Willebrand cancer disease except for surgical 24.10.2006 Human plasma coagulation Factor and/or invasive procedures in patients with von VIII and human plasma von Willebrand disease in whom desmopressin is either Willebrand Factor Wilate Reversalineffective of or anticoagulation contraindicated therapy in patients needing 18.04.2007 Human prothrombin complex treatment of serious or life threatening bleeding and/or concentrate Octaplex needing urgent surgery or invasive procedures 01.02.2008 human recombinant fusion protein Treatment of hypophosphatasia 12.09.2008 Human telomerase reverse transcriptase peptide vaccine Treatment of pancreatic cancer 20.07.2006 Human T-lymphotropic virus type III Gp160 antigens Vaxsyn HIV-1 Treatment of AIDS. 20.11.1989

Human umbilical tissue-derived cells Treatment of retinitis pigmentosa 13.03.2006

Humanized anti-CD2 monoclonal antibody Treatment of graft-versus-host disease. 13.11.1998

Humanized anti-CD3 monoclonal antibody Treatment of recent-onset Type I diabetes 29.09.2006 humanized anti-human CD16 monoclonal antibody ForTreatment the induction of adult of idiopathic donor-specific thrombocytopenic immunologic purpura 21.03.2005 unresponsiveness resulting in prophylaxis of organ Humanized anti-human CD2 MAb MEDI-507 rejection without the need for chronic 17.09.1998

Prevention of acute graft-vs-host disease following Humanized anti-tac Zenapax bone marrow transplantation. 05.03.1993

Treatment of vaso-occlusive crisis in patients with humanized IgG2 antibody sickle cell disease. 22.07.2008

Humanized MAb (IDEC-131) to CD40L ToTreatment prevent ofthe systemic development lupus oferythematosus. or to decrease the 09.02.1999 incidence and severity of hemolytic uremic syndrome humanized monoclonal antibody and associated sequelae of Shiga-like toxin-producing against Shiga-like toxin II E. coli. 12.09.2001 Humanized monoclonal antibody to the high affinity folate alpha receptor Treatment of ovarian cancer 16.06.2006 humanized monocloncal antibody against human integrin Treatment of fibrosis-associated chronic allograft alphaVbeta6 nephropathy in kidney transplant patients. 18.06.2008

Treatment of emphysema in patients due to alpha-1 hyaluronic acid Treatmentantitrypsin deficiencyof severe intrapartum hypertension (diastolic 19.03.2002 blood pressure greater than or equal to 110 or systolic Hydralazine blood pressure greater than or equal to 160) associated 09.04.2004 hydrocortisone modified release tabs DuoCort Treatment of adrenal insufficiency 18.06.2008 Hydroxocobalamin Treatment of acute cyanide poisoning 22.09.2000

Hydroxycobalamin/sodium thiosulfate Treatment of severe acute cyanide poisoning. 04.10.1985 hydroxyurea Treatment of pediatric patients with sickle cell anemia. 15.04.2005

Hypericin Treatment of glioblastoma multiforme. 03.08.2000

Hypericin Treatment of cutaneous T-cell lymphoma. 07.02.2000

I(131)-TM-601 (chlorotoxin) Treatment of malignant glioma 14.02.2002

Iboctadekin Treatment of renal cell carcinoma 03.06.2005

Ibuprofen i.v. solution Salprofen Prevention of patent ductus arteriosus. 29.10.1996

Treatment of burn patients hospitalized with burn- icatibant induced edema 05.05.2004 icatibant Treatment of angioedema 25.11.2003

Idarubicin Idamycin Treatment of chronic myelogenous leukemia. 02.12.1992

Idarubicin Idamycin Treatment of myelodysplastic syndromes. 01.12.1992

Treatment of acute lymphoblastic leukemia in pediatric Idarubicin HCl for injection Idamycin patients. 12.02.1991 idebenone Treatment of Leber's hereditary optic neuropathy. 31.10.2006 idebenone Treatment of Duchenne muscular dystrophy 16.02.2007

Idebenone Treatment of Friedreich's ataxia 25.03.2004

Idoxuridine Treatment of nonparenchymatous sarcomas. 08.04.1996

IDUA-HIRMAb fusion protein AGT-181 Treatment of mucopolysaccharidosis Type 1 (MPS) 10.01.2008

Ifosfamide Ifex Treatment of bone sarcomas 07.08.1985

Ifosfamide Ifex Treatment of soft tissue sarcomas. 07.08.1985

IL13-PE38QQR Treatment of malignant glioma 02.11.2001

IL-4 Pseudomonas Toxin Fusion Protein (IL-4(38-37)-PE38KDEL) Treatment of astrocytic glioma. 06.04.2000

Treatment of Raynaud's phenomenon secondary to Iloprost solution for infusion systemic sclerosis. 21.09.1989

Iloprost solution for infusion Treatment of heparin-associated thrombocytopenia. 14.05.1990

Detecting early necrosis as an indication of rejection of Imciromab pentetate Myoscint orthotopic cardiac transplants. 25.01.1989 imexon Amplimexon Treatment of ovarian cancer. 12.08.2005

Imexon Treatment of multiple myeloma. 08.11.1996

Imexon Treatment of pancreatic adenocarcinoma 01.11.2003 Imexon Treatment of metastatic malignant melanoma 03.08.2001 Immortalized human liver cells found in the extracorporeal liver Treatment of fulminant hepatic failure (acute liver assist device ELAD failure) 16.07.2004 Immune Globulin (Human) containing high titers of West Nile virus antibodies Omr-IgG-am (tm) 5% Treatment( of the West Nile virus infection 17.03.2004

Immune Globulin Intravenous (human) Carimune NF Treatment for Guillain Barre Syndrome 04.05.2004 Immune globulin intravenous (human) Gammagard Liquid Treatment of multifocal motor neuropathy 20.07.2006

Immune globulin intravenous (human) Immune Globulin IntravTreatment of patients with acute myocarditis. 22.11.1993

Immune globulin intravenous (human) Iveegam, Immuno Treatment of polymyositis/dermatomyositis. 13.10.1992

Immune globulin intravenous (human) Iveegam, Immuno Treatment of patientsjuvenile rheumatoidwith primary arthritis. immune deficiency 16.12.1992 (PID) that are intolerant to immune globulin intravenous Immune Globulin Subcutaneous (IGIV) due to severe adverse events or poor venous (Human) Vivaglobin P (proposedaccess 22.09.2004

Implitapide Treatment of homozygous familial hypercholesterolemia 13.08.2004

Treatment of patients with Fredrickson type I or V Implitapide Forhyperlipoproteinemia skin testing of victims of fire ant stings to confirm 19.08.2004 fire ant sensitivity and if positive, for use as Imported fire ant venom, allergenic immunotherapy for the prevention of IgE-mediated extract anaphylactic reactions. 12.05.1992

Inalimarev and falimarev Treatment of adenocarcinoma of the pancreas 10.01.2006

Indium In 111 murine monoclonal antibody FAB to myosin Myoscint To aid in the diagnosis of myocarditis. 07.08.1989

Indium In-111 altumomab Detection of suspected and previously unidentified pentetate Hybri-ceaker tumor foci of recurrent colorectal carcinoma. 06.02.1990 Indium-111 pentetreotide NeuroendoMedix Treatment of neuroendocrine tumors 16.06.2006 infliximab Remicade Treatment of juvenile rheumatoid arthritis 23.10.2002 infliximab Remicade Treatment of giant cell arteritis 06.05.2003

Treatment of pediatric (0 to 16 years of age) ulcerative Infliximab REMICADE colitis 12.11.2003

Infliximab Remicade Treatment of chronic sarcoidosis 21.05.2003

INGN 201 ADVEXIN Treatment of head and neck cancer 27.01.2003

Reduction (prevention) of nosocomial bacteremia INH-A00021 Veronate caused by staphylococci in very low birth weight infants. 13.06.2001 inolimomab Leukotac Treatment of graft versus host disease 23.10.2002

Inosine pranobex Isoprinosine Treatment of subacute sclerosing panencephalitis. 20.09.1988

Interferon alfa-2a (recombinant) Roferon-A Treatment of renal cell carcinoma. 18.04.1988 For the treatment of metastatic malignant melanoma in Interferon alfa-2a (recombinant) Roferon-A combination with Teceleukin. 11.05.1990

For the concomitant administration with Teceleukin for Interferon alfa-2a (recombinant) Roferon-A the treatment of metastatic renal cell carcinoma. 02.05.1990

For the concomitant administration with fluorouracil for Interferon alfa-2a (recombinant) Roferon-A the treatment of advanced colorectal cancer. 14.05.1990

For use in combination with fluorouracil for the Interferon alfa-2a (recombinant) Roferon-A treatment of esophageal carcinoma. 27.10.1989

Interferon alfa-2b (recombinant) Intron A Treatment of acute hepatitis B. 17.11.1988 Interferon alfa-2b (recombinant) Intron A Treatment of primary malignant brain tumors. 13.05.1988

Interferon alfa-2b (recombinant) Intron A Treatment of carcinoma in situ of the urinary bladder. 10.08.1988

Interferon alfa-2b (recombinant) Intron A Treatment of invasive carcinoma of the cervix. 18.04.1988

Interferon alfa-2b (recombinant) Intron A Treatment of ovarian carcinoma. 03.08.1987

Interferon alfa-2b (recombinant) Intron A Treatment of chronic myelogenous leukemia. 22.06.1987

Interferon alfa-2b (recombinant) Intron A Treatment of metastatic renal cell carcinoma. 22.06.1987

Interferon alfa-2b (recombinant) Intron A Treatment of laryngeal (respiratory) papillomatosis. 17.08.1988

Interferon alfa-2b (recombinant) Intron A Treatment of chronic delta hepatitis. 04.05.1990 Treatment of human papillomavirus in patients with severe resistant/recurrent respiratory (laryngeal) Interferon alfa-nl Wellferon papillomatosis. 16.10.1987

Interferon alfa-nl Wellferon Treatment of AIDS related Kaposi's sarcoma. 25.08.1986

For the systemic treatment of metastatic renal cell Interferon beta (recombinant) R-IFN-beta carcinoma. 12.02.1991

For the intralesional and/or systemic treatment of AIDS- Interferon beta (recombinant) r-HuIFN-beta related Kaposi's sarcoma. 09.05.1991 For the systemic treatment of cutaneous T-cell Interferon beta (recombinant) r-HuIFN-beta lymphoma. 18.04.1991

Interferon beta, recombinant human Betaseron Treatment of acquired immunodeficiency syndrome. 15.11.1988 Treatment of patients with secondary progressive Interferon beta-1a Rebif multiple sclerosis. 11.03.1996 interferon Beta-1a Avonex Treatment of juvenile rheumatoid arthritis. 14.10.1998

Interferon beta-1a (recombinant human) Treatment of acute non-A, non-B hepatitis. 24.07.1992

For the systemic treatment of cutaneous malignant Interferon beta-1a (recombinant) r-HuIFN-beta melanoma. 03.04.1991 Treatment of symptomatic patients with AIDS including all patients with CD4 T-cell counts less than 200 cells Interferon beta-1a (recombinant) Rebif per mm3. 02.12.1992

Interferon gamma Treatment of idiopathic pulmonary fibrosis 11.10.2007 interferon gamma-1b Actimmune Treatment of idiopathic pulmonary fibrosis 12.09.2002

Interferon gamma-1b Actimmune Treatment of renal cell carcinoma. 04.12.1995

Interferon-alfa-1b Treatment of multiple myeloma 17.04.2001 Interleukin-1 alpha, human recombinant For hematopoietic potentiation in aplastic anemia. 17.06.1991

Interleukin-1 alpha, human For the promotion of early engraftment in bone marrow recombinant transplantation. 17.06.1991

Interleukin-1 receptor antagonist, human recombinant Antril Treatment of juvenile rheumatoid arthritis. 23.09.1991

Interleukin-1 receptor antagonist, Prevention and treatment of graft versus host disease human recombinant Antril in transplant recipients. 16.10.1992

Treatment of Still's disease including juvenile Interleukin-1 Trap rheumatoid arthritis and adult-onset Still's disease 04.04.2005

In combination with interferon alfa-2a for the treatment Interleukin-2 Teceleukin of metastatic malignant melanoma. 11.05.1990

Interleukin-2 Teleleukin Treatment of metastatic malignant melanoma. 06.02.1990

Interleukin-2 Teceleukin Treatment of metastatic renal cell carcinoma. 05.02.1990 In combination with interferon alfa-2a for the treatment Interleukin-2 Teceleukin of metastatic renal cell carcinoma. 03.05.1990 Promotion of erythropoiesis in Diamond-Blackfan Interleukin-3 human (recombinant) Foranemia sequential (congenital administration pure red cell with aplasia). sargramostim to 20.05.1991 accelerate neutrophil and platelet recovery in patients Interleukin-3, human, recombinant undergoing autologous bone marrow transplantation for 30.09.1993

Prevention of dental caries due to radiation-induced Intraoral fluoride releasing system IFRS xerostomia in patients with head and neck cancer 31.07.2001

Intravenous immune globulin VitiGam Treatment of Stage IIB to IV malignant melanoma 26.07.2007

Intravenous immune globulin (human) 10% Octagam Treatment of stiff-person syndrome 31.07.2008 iobenguane I 131 Treatment of neuroendocrine tumors 05.07.2007

Iobenguane I 131 Azedra Ultratrace Treatment of neuroendocrine tumors 18.01.2006

For scintigraphic detection, localization and staging of Iobenguane Sulfate I-123 OmaClear neuroblastoma. 17.10.2005 For the detection, localization, and staging of iobenguane sulfate I-123 OmaClear pheochromocytomas. 21.10.2005

Iodine 131 6B-iodomethyl-19- norcholesterol For use in adrenal cortical imaging. 01.08.1984

Iodine I 123 murine monoclonal Detection of alpha-fetoprotein producing germ cell antibody to alpha-fetoprotein tumors. 30.09.1988

Iodine I 123 murine monoclonal Detection of hepatocellular carcinoma and antibody to alpha-fetoprotein hepatoblastoma. 30.09.1988

Iodine I 123 murine monoclonal Detection of hCG producing tumors such as germ cell antibody to hCG and trophoblastic cell tumors. 07.11.1988 Iodine I 131 bis(indium- diethylenetriaminepentaacetic acid)tyrosyllysine/hMN-14 x m734 Pentacea Treatment of small-cell lung cancer. 22.02.2000

Iodine I 131 Lym-1 Monoclonal Antibody Treatment of B-cell lymphoma. 02.11.1987 Iodine I 131 murine monoclonal antibody IgG2a to B cell Immurait, Ll-2-I-131 Treatment of B-cell leukemia and B-cell lymphoma. 18.09.1989

Iodine I 131 murine monoclonal Treatment of alpha-fetoprotein producing germ cell antibody to alpha-fetoprotein tumors. 30.09.1988

Iodine I 131 murine monoclonal Treatment of hepatocellular carcinoma and antibody to alpha-fetoprotein hepatoblastoma. 30.09.1988

Iodine I 131 murine monoclonal Treatment of hCG producing tumors such as germ cell antibody to hCG and trophoblastic cell tumors. 07.11.1988 Iodine I-131 radiolabeled chimeric Treatment of glioblastoma multiforme and anaplastic MAb tumor necrosis treatment 131IchTNT-1 astrocytoma. 12.02.1999 irofulven Treatment of renal cell carcinoma. 27.07.1999

irofulven Treatment of ovarian cancer. 06.07.1999

Isobutyramide Treatment of sickle cell disease and beta thalassemia. 25.05.1994

Treatment of beta-hemoglobinopathies and beta- Isobutyramide Isobutyramide oral soluthalassemia syndromes. 18.12.1992 isofagomine tartrate Treatment of Gaucher disease 10.01.2006

Itraconazole suspension ForTopical ventricular treatment tachycardia, of fungal otitisventricular externa fibrillation, (otomycosis) or the 30.10.2008 maintenance of sinus rhythm in patients converted from atrial fibrillation or atrial flutter when oral administration IV Sotalol So-Aqueous is not possible. 25.07.2008

JAK tyrosine kinase inhibitor Treatment of myelofibrosis 05.09.2008

Japanese encephalitis vaccine (live, attenuated) ForPrevention use with of cyclosporine Japanese encephalitis. A to diminish the 19.05.1999 nephrotoxicity induced by cyclosporine in organ Ketoconazole Nizoral transplantation. 27.03.1991 kit for the preparation of For localization of sentinel lymph nodes in patients with technetium Tc99m sulfur colloid melanoma. 17.03.2009

L-2-oxothiazolidine-4-carboxylic acid Procysteine Treatment of adult respiratory distress syndrome. 14.06.1994

L-2-oxothiazolidine-4-carboxylic acid Procysteine Treatment of amyotrophic lateral sclerosis. 30.07.1996

L-5-hydroxytryptophan Treatment of tetrahydrobiopterin deficiency. 20.01.1999 Treatment of severe aphthous stomatitis in severely, Lactic acid Aphthaid terminally immunocompromised patients. 29.06.1999 lactic acid bacteria (Lactobacilli, Bifidobacteria, and Steptococci) Treatment of active chronic pouchitis 15.01.2002 lactic acid bacteria (Lactobacilli, Bifidobacteria, and Streptococcus Prevention of disease relapse in patients with chronic species) pouchitis 15.01.2002

Treatment of AIDS-associated diarrhea unresponsive to Lactobin Lactobin initial antidiarrheal therapy. 12.09.1990

L-aminocarnityl-succinyl-leucyl- Treatment of Duchenne and Becker muscular argininal-diethylacetal dystrophy 18.01.2006 laromustine Onrigin Treatment of acute myelogenous leukemia 21.10.2004

Latrodectus immune F(ab)2 Aracmyn Treatment of black widow spider envenomations 18.06.2001

L-baclofen Treatment of trigeminal neuralgia. 13.07.1990 Treatment of intractable spasticity in children with L-Baclofen Neuralgon cerebral palsy. 30.01.1992

Treatment of intractable spasticity associated with L-baclofen Neuralgon spinal cord injury or multiple sclerosis. 17.12.1991

L-Baclofen Treatment of trigeminal neuralgia. 06.01.1998 L-cycloserine Treatment of Gaucher's disease. 01.08.1989

For the prevention and lessening of photosensitivity in L-cysteine erythropoietic protoporphyria. 16.05.1994

Prevention of acute and chronic rejection in patients Leflunomide who have received solid organ transplants. 18.10.1996 lenalidomide Revlimid(r) Treatment of mantle cell lymphoma 27.04.2009 lenalidomide Revlimid Treatment of chronic lymphocytic leukemia. 17.01.2007

Lentiviral vector encoded with a Treatment of beta-thalassemia major and beta- human beta-globin gene plasmid Thalagen thalassemia intermedia 11.01.2006

Lestaurtinib Treatment of acute myeloid leukemia 24.03.2006

For use in combination with 5-fluorouracil for the Leucovorin calcium Wellcovorin treatment of metastatic colorectal cancer. 23.06.1988

Neoadjuvant therapy in patients with squamous cell leukocyte interlukin Multikine carcinoma of the head and neck 04.05.2007

For use as an adjunct to microsurgical peripheral nerve Leupeptin repair. 18.09.1990 Levocabastine HCl ophthalmic suspension 0.05% Treatment of manifestationsvernal keratoconjunctivitis. of carnitine deficiency in 29.02.1988 patients with end stage renal disease who require Levocarnitine Carnitor dialysis. 24.11.1986

For the treatment of secondary carnitine deficiency in Levocarnitine Carnitor valproic acid toxicity. 15.11.1989

For the prevention of secondary carnitine deficiency in Levocarnitine Carnitor valproic acid toxicity. 15.11.1989

Treatment of zidovudine-induced mitochondrial Levocarnitine Carnitor myopathy. 07.04.1997 Levocarnitine Carnitor Treatment of pediatric cardiomyopathy. 22.11.1993

Levodopa and carbidopa Duodopa Treatment of late stage Parkinson's disease. 18.01.2000 Pseudomonas aeruginosa and other bacteria in Levofloxacin patients with cystic fibrosis patients 27.02.2008

L-glutamine Treatment of sickle cell disease 01.08.2001

L-glutamyl-L-tryptophan Treatment of AIDS-related Kaposi's sarcoma. 20.10.1999 liarozole The treatment of congenital ichthyosis 18.06.2004

Lintuzumab Treatment of myelodysplastic syndrome 20.03.2007 lintuzumab Treatment of acute myeloid leukemia. 30.01.2007 lintuzumab Zamyl Treatment of acute myelogenous leukemia 09.09.2002

Lipid/DNA human cystic fibrosis gene Treatment of cystic fibrosis. 08.04.1996

Liposomal amphotericin B AmBisome Treatment of histoplasmosis. 10.12.1996

Liposomal annamycin Treatment of acute myeloid leukemia 17.06.2005

Liposomal annamycin Treatment of acute lymphoblastic leukemia 17.06.2005

Liposomal ciprofloxacin Management of bronchiectasis 27.12.2006 Liposomal ciprofloxacin for inhalation Management of cystic fibrosis 19.04.2006

Liposomal cisplatin LipOva-Pt Treatment of ovarian cancer 23.05.2006 For aerosolized administration in the prevention and treatment of lung allograft rejection and pulmonary rejection events associated with bone Liposomal cyclosporin A Cyclospire marrow transplantation. 30.04.1998 liposomal cyclosporine for inhalation Prevention of bronchiolitis obliterans. 24.06.2008

Liposomal doxorubicin hydrochloride Sarcodoxome Treatment of soft tissue sarcomas 27.12.2006 liposomal gadodiamide Treatment of glioma. 12.11.2008

Liposomal N-Acetylglucosminyl-N- Acetylmuramly-L-Ala-D-isoGln-L- Ala -gylcerolidpalmitoyl ImmTher Treatment of osteosarcoma. 10.06.1998 Liposomal N-Acetylglucosminyl-N- Acetylmuramly-L-Ala-D-isoGln-L- Ala -gylcerolidpalmitoyl ImmTher Treatment of Ewing's sarcoma. 10.06.1998

Liposomal nystatin Nyotran Treatment of invasive fungal infections. 13.06.2000 liposomal p-ethoxy growth receptor bound protein-2 antisense product Treatment of chronic myelogenous leukemia 05.12.2003

Liposomal prostaglandin E1 injection Treatment of acute respiratory distress syndrome. 25.04.1996 liposomal topotecan hydrochloride Treatment of gliomas 30.10.2008 Liposomal-cis-bis-neodecanoato- trans-R,R-1,2-diaminocyclohexane- Pt (II) Aroplatin Treatment of malignant mesothelioma. 01.09.1999

Liposome encapsulated recombinant interleukin-2 Treatment of brain and CNS tumors. 25.11.1991

Liposome encapsulated recombinant interleukin-2 Treatment of cancers of the kidney and renal pelvis 20.06.1994

Treatment of patients undergoing induction therapy for Lisofylline acute myeloid leukemia. 10.06.1999 For use in combination chemotherapy with the approved agent 5-fluorouracil in the palliative treatment L-leucovorin Isovorin of metastatic adenocarcinoma of the colon and rectum. 18.12.1990

Loxoribine Treatment of common variable immunodeficiency. 24.02.1992

Treatment of spasticity associated with familial spastic L-threonine paraparesis. 24.07.1992

L-threonine Threostat Treatment of amyotrophic lateral sclerosis. 06.02.1989

L-threonyl-L-prolyl-L-prolyl-L- Treatment of neuropathic pain associated with spinal threonine cord injury 26.04.2005

L-tyrosine-L-serine-L-leucine CMS-024 Treatment of hepatocellular carcinoma. 10.09.2004

Prevention of bronchopulmonary dysplasia in Lucinactant Surfaxin premature infants 23.05.2006

Treatment of bronchopulmonary dysplasia in premature Lucinactant Surfaxin infants. 21.10.2005

Treatment of meconium aspiration syndrome in Lucinactant Surfaxin newborn infants 30.07.1996

Treatment of acute respiratory distress syndrome in Lucinactant Surfaxin adults. 17.07.1995

Treatment of respiratory distress syndrome in Lucinactant Surfaxin premature infants. 18.10.1995 Treatment of pain and fever secondary to sickle cell Lysine acetylsalicylate injectable disease crisis. 01.08.1989 lysosomal enzyme N- acetylgalactosamine-6-sulfate Treatment of mucopolysaccharidosis Type IVA sulfatase (Morquio Syndrome) 10.09.2008 lyso-thermosensitive lipsomal doxorubicin ThermoDox (r) For treatment of hepatocellular carcinoma. 17.03.2009 macitentan Treatment of idiopathic pulmonary fibrosis. 14.04.2009 Mafosfamide Treatment of neoplastic meningitis 21.01.2003

MAGE-A3 cancer therapeutic Treatment of MAGE-A3 expressing head and neck Trojan peptide vaccine squamous cell carcinoma 24.11.2008

Mammalian target of rapamcyin (mTOR) inhibitor Treatment of soft tissue sarcoma 12.08.2005

Manganese superoxide dismutase Prevention of radiation- or chemotherapy-induced oral mimetic mucositis in cancer patients 27.02.2008 For use to facilitate clearance of mucus in patients with bronchiectasis and in patients with cystic fibrosis at risk Mannitol Bronchitol for bronchiectasis 11.02.2005 Treatment of high-risk Stage II, Stage III, and Stage IV mannopentaose phosphate sulfate melanoma 27.04.2004

Prevention of cytomegalovirus viremia and disease in maribavir the populations at risk. 01.02.2007

Marijuana Treatment of HIV-associated wasting syndrome. 25.05.1999

Matrix metalloproteinase inhibitor Galardin Treatment of corneal ulcers. 05.12.1991

MaxAdFVIII Treatment of Hemophilia A 03.03.2003

Mazindol Sanorex Treatment of Duchenne muscular dystrophy. 08.12.1986

Mecamylamine Inversine Treatment of Tourette's syndrome. 14.10.1998 mecasermin Iplex Treatment of myotonic dystrophy 03.12.2007

Mecasermin Myotrophin Treatment of amyotrophic lateral sclerosis. 05.08.1991 meclorethamine or nitrogen mustard Treatment of mycosis fungoides. 12.08.2004 For the treatment of of stage IIb, stage IIc, stage III and MEDI-522 Vitaxin stage IV melanoma 14.04.2004

Medroxyprogesterone acetate Hematrol Treatment of immune thrombocytopenic purpura. 22.02.2001

Mefloquine HCl Mephaquin Prevention of chloroquine-resistant Falciparum malaria. 22.07.1987

Mefloquine HCl Mephaquin Treatment of chloroquine-resistant Falciparummalaria. 22.07.1987

Melanoma autologous dendritic Treatment of stage IIIb through IV metastatic cell vaccine melanoma 06.09.2006

Melanoma cell vaccine Canvaxin Treatment of invasive melanoma. 13.10.1994

Treatment of HLA-A2+ patients with stage IIB, IIC, III, Melanoma peptide vaccine and IV malignant melanoma 29.03.2005

Melanoma vaccine Melacine Treatment of stage III - IV melanoma. 20.12.1989

Treatment of non-24-hour sleep-wake disorder in blind Melatonin Circadin individuals without light perception 09.07.2004

Treatment of circadian rhythm sleep disorders in blind Melatonin people with no light perception. 15.11.1993

High dose conditioning treatment prior to hematopoietic melphalan progenitor (stem) cell transplantation 24.11.2008

For use in hyperthermic regional limb perfusion to treat Melphalan Alkeran for Injection metastatic melanoma of the extremity. 03.03.1992 melphalan hydrochloride Treatment of patients with ocular (uveal) melanoma. 12.11.2008 melphalan hydrochloride Treatment of patients with cutaneous melanoma. 12.11.2008 mepivacaine Treatment of postherpetic neuralgia 08.01.2007

Mepivacaine Treatment of painful HIV-associated neuropathy 18.10.2006

For first-line treatment in patients with hypereosinophilic mepolizumab syndrome 28.05.2004 Management of acute pulmonary exacerbations, in cystic fibrosis patients, due to respiratory tract infection Meropenem Merrem IV with susceptible organisms. 27.04.2000

Treatment of active, mild to moderate ulcerative colitis mesalamine; 5-aminosalicylic acid Lialda in children 5 to 17 years 27.02.2008 Inhibition of the urotoxic effects induced by oxazaphosphorine compounds such as Mesna cyclophosphamide. 16.12.1987

Methionine/L-methionine Treatment of AIDS myelopathy. 21.08.1996 methotrexate Rheumatrex Treatment of juvenile rheumatoid arthritis. 23.08.1993

Methotrexate with laurocapram Methotrexate/azone Topical treatment of mycosis fungoides. 15.10.1990

For use in conjunction with the UVAR photopheresis Methoxsalen Uvadex system to treat graft versus host disease. 14.10.1998 Treatment of metabolic disorders secondary to metreleptin lipodystrophy 22.08.2001

Treatment of leptin deficiency secondary to generalized metreleptin lipodystrophy and partial familial lipodystrophy 22.08.2001

metronidazole Treatment of pouchitis 17.09.2008

Metronidazole Metrogel Treatment of perioral dermatitis. 24.10.1991 Treatment of grade III and IV, anaerobically infected, Metronidazole (topical) Flagyl decubitus ulcers. 24.11.1987

Metronidazole 10% ointment Topical treatment of active perianal Crohn's disease 08.11.2007

Treatment of velocardiofacial syndrome associated metyrosine Demser psychosis. 25.07.2008 mibefradil Treatment of pancreatic cancer. 16.10.2008

Mibefradil Treatment of ovarian cancer 15.06.2007

Intraoperative aid in the identification and localization of Microbubble contrast agent Filmix Neurosonographintracranial tumors. 16.11.1990

Microvesiculated modified Treatment of cutaneous bleeding episodes in patients glycosylated tissue factor with von Willebrand disease. 11.10.2007 Treatment of non-life threatening, mild to severe Microvesiculated modified bleeding episodes due to cutaneous injuries or dental glycosylated tissue factor Treatmentprocedures of in bouts hemophiliac of increased patients seizure activity in 25.01.2007 selected refractory patients with epilepsy who are on stable regimens of anti-epileptic drugs and who require Midazolam HCl intermittent use of midazolam 08.05.2006 mifamuritide Junovan Treatment of osteosarcoma 05.06.2001

Treatment of Cushing's syndrome secondary to ectopic Mifepristone ACTH secretion 07.02.2005

Treatment of the clinical manifestations of endogenous mifepristone Corlux Cushing's symdrome. 05.07.2007

Treatment of the neurological manifestations of miglustat Zavesca (r) Niemann-Pick disease,type C. 12.11.2008 milatuzumab Treatment of chronic lymphocytic leukemia. 24.06.2008 milatuzumab Treatment of multiple myeloma 10.03.2008 Topical treatment of cutaneous lymphoma encompassing cutaneous manifestations of T-cell miltefosine Miltex(r) / Impavido(r)lymphoma and B-cell lymphoma 18.03.2009 miltefosine Impavido Treatment of leishmaniasis. 10.10.2006

Minocycline HCl Minocin Intravenous Treatment of chronic malignant pleural effusion. 19.06.1992

Minocycline hydrochloride Treatment of sarcoidosis 28.03.2006 Treatment of intrauterine fetal death not accompanied by complete expulsion of the products of conception in misoprostol GyMiso the second and third trimesters of pregnancy. 10.01.2005 including AIDS-related diffuse non-Hodgkin's Mitoguazone apep lymphoma. 18.03.1994

Treatment of invasive carcinoma of the uterine cervix Mitolactol 23.01.1989

As adjuvant therapy in the treatment of primary brain Mitolactol tumors. 12.07.1995

Treatment of refractory glaucoma as an adjunct to ab mitomycin-C Trabomycin externo glaucoma surgery. 08.01.2008

Treatment of refractory glaucoma as an adjunct to ab Mitomycin-C externo glaucoma surgery. 20.08.1993

MN14 monoclonal antibody to carcinoembryonic antigen Cea-Cide Treatment of small cell lung cancer 18.09.1998

MN14 monoclonal antibody to carcinoembryonic antigen Cea-Cide Treatment of pancreatic cancer. 24.11.1998

Treatment of AIDS patients with neutropenia due to the Molgramostim Leucomax disease, AZTor ganciclovir. 24.01.1989 Molgramostim Leucomax Treatment of aplastic anemia. 25.09.1989 monarsen Treatment of Myasthenia Gravis 14.11.2003 Monoclonal Ab(murine) anti- idiotype melanoma-associated antigen Melimmune Treatment of invasive cutaneous melanoma. 19.09.1994

Monoclonal antibodies (murine or human) to B-cell lymphoma Treatment of B-cell lymphoma. 06.05.1986

Monoclonal antibody 17-1a Panorex Treatment of pancreatic cancer. 04.04.1988 monoclonal antibody 3F8 Treatment of neuroblastoma 16.09.2008 Monoclonal antibody for immunization against lupus nephritis Treatment of lupus nephritis. 07.01.1993

Monoclonal antibody to Treatment of cytomegalovirus retinitis in patients with cytomegalovirus (human) AIDS. 15.11.1991

Monoclonal antibody to Prophylaxis of cytomegalovirus disease in patients cytomegalovirus (human) undergoing solid organ transplantation. 13.09.1991 Prophylaxis of hepatitis B reinfection in patients Monoclonal antibody to hepatitis B undergoing liver transplantation secondary to end-stage virus (human) chronic hepatitis B infection. 17.06.1991

Monoclonal antibody-B43.13 Ovarex MAb-B43.13 Treatment of epithelial ovarian cancer. 25.11.1996

Monoclonal antiendotoxin antibody Treatment of patients with gram-negative sepsis which XMMEn-0e5 has progressed to shock. 04.11.1985

Monolaurin Glylorin Treatment of congenital primary ichthyosis. 29.04.1993

For use in conjunction with whole brain radiation for the motexafin gadolinium Xcytrin treatment of brain metastases arising from solid tumors 27.01.2003 MTC-DOX for Injection Treatment of hepatocellular carcinoma 03.01.2001 Mucoid exopolysaccharide Treatment of pulmonary infections due to Pseudomonas hyperimmune Pseudomonas aeruginosa in patients with cystic globulin MEP IGIV fibrosis. 09.01.1991 Mucoid exopolysaccharide Pseudomonas aeruginosa in patients with cystic Pseudomonas hyperimmune MEP IGIV Treatmentfibrosis. of patients with functional 07.11.1990 gastroenteropancreatic (GEP) neuroendocrine tumors (specifically, carcinoid, insulinoma, gastrinoma, Multi-ligand somatostatin analogue somastatinoma, GRFoma, VIPoma and glucagonoma. 27.07.2004 Multi-vitamin infusion (neonatal For establishment and maintenance of total parenteral formula) nutrition in very low birth weight infants. 12.12.1989 Murine MAb (Lym-1) and Iodine 131-I radiolabeled murine MAb (Lym-1) to human B-cell Oncolym Treatment of B-cell non-Hodgkin's lymphoma. 27.11.1998 Murine MAb to polymorphic epithelial mucin, human milk fat globule 1 Theragyn Adjuvant treatment of ovarian cancer. 22.03.1999

Mx-dnG1 Rexin-G(R) Treatment for soft tissue sarcoma. 24.06.2008

Mx-dnG1 Rexin-G Treatment of osteosarcoma. 24.06.2008

Mx-dnG1 or Rexin-G retroviral vector REXIN-G Treatment of pancreatic cancer 15.08.2003

Mycobacterium avium sensitin RS- For use in the diagnosis of invasive Mycobacterium 10 avium disease in immunocompetent individuals. 11.10.1995

Mycophenolate mofetil CellCept Treatment of pemphigus vulgaris 26.05.2006

Myelin Treatment of multiple sclerosis. 27.06.1991

Prevention of retinopathy of prematurity in preterm myo-inositol infants at risk for developing retinopathy of prematurity 07.04.2005 myristoylated recombinant SCR1- 3 of human complement reseptor Prevention of delayed graft function in solid organ type I APT070 transplant 21.05.2003 N-((methyl-diazacyclohexyl- methylbenzamide)-asaphenyl- Treatment of malignant gastrointestinal stromal tumors. 20.04.2005 N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'- (trifluoromethyl)[1,1'biphenyl]-2- yl]carbonyl]amino]-1- Treatment of homozygous familial hypercholesterolemia 23.10.2007 N-(2,3-dihydro-3,3-dimethyl-1H- indol-6-yl)-2-[(4- pyridinylmethyl)amino]-3- Treatment of gastrointestinal stromal tumors 13.01.2005 N-(2,4-Di-tert-butyl-5- hydroxyphenyl)-1,4-dihydro-4- Treatment of patients with cystic fibrosis. 20.12.2006 N-(2-amino-phenyl)-4-[(4-pyridin-3- yl-pyrimidin-2-ylamino)-methyl] Treatment of Hodgkin's lymphoma 08.08.2007 N-(2-amino-phenyl)-4-[(4-pyridin-3- yl-pyrimidin-2-ylamino)-methyl] Treatment of acute myeloid leukemia 01.02.2008 N-(5-tert-Butylisoxazol-3-yl)-N'-{4- [7-(2-(morpholin-4-yl)ethoxy) imidazo[2,1-b][1,3]benzothiazol-2- Treatment of acute myeloid leukemia 18.03.2009 N-(methyl-diazacyclohexyl- methylbenzamide)-azaphenyl- aminothiopyrrole) mesylate Treatment of multiple myeloma. 17.10.2005 N-[2-[(4-hydroxyphenyl)amino]-3- pyridinyl]-4- methoxybenzenesulfonamide Treatment of neuroblastoma 30.09.2004 N-[3-(4',5'-bipyrimidin-2-ylamino)-4- methylphenyl]-4-{[(3S)-3- Treatment of Philadelphia chromosome-positive chronic (dimethylamino)pyrrolidin-1- myelogenous leukemia. 27.12.2006 N-[4-(3-amino-1H-indazol-4- yl)phenyl]-N1-(2-fluoro-5- methylphenyl) urea Treatment of acute myelogenous leukemia 23.10.2007 N-[4-(3-amino1H-indazol-4- yl)phenyl]-N1-(2-fluoro-5- methylphenyl)urea Treatment of hepatocellular carcinoma 23.05.2007 N-[4-(4-amino-2-ethyl-1H- imidazo[4,5-c]quinolin-1- yl)butyl]methanesulfonamide Treatment of stages IIB-IV melanoma 13.08.2004 N-[4-(4-amino-2-ethyl-lH- imidazo[4,5-c]quinolin-1- yl)butyl]methanesulfonamide Treatment of cutaneous T-cell lymphoma 24.03.2006 N-[4-bromo-2-(1H-1,2,3,4-tetrazol- 5-yl)phenyl]-N'-[3,5- bis(trifluoromethyl)phenyl]urea Treatment of sickle cell disease 13.05.2002 N2'-Deacetyl-N2'-[4-methyl-4- (oxobuthyldithio)-1-oxopentyl]- maytansine-chimerized anti- Treatment of multiple myeloma 27.02.2008 nabumetone For treatment of pediatric juvenile rheumatoid arthritis. 05.05.2008

N-acetylcysteinate Lysine Nacystelyn Dry PowderFor the management of cystic fibrosis 27.12.2000

N-acetylcysteine Treatment of acute liver failure 09.09.2002

N-acetyl-glucosamine thiazoline ToTreatment lower the of defibrillationadult Tay-Sachs energy disease requirement 06.02.2006 sufficiently to allow automatic implantable cardioverter defibrillator therapy in those patients who could N-acetylprocainamide Napa otherwise not use the device. 23.03.1990

Prevention of life-threatening ventricular arrhythmias in N-acetyl-procainamide patients with documented procainamide-induced lupus. 10.12.1996 N-acetyl-sarcosyl-glycyl-L-valyl-D- alloisoleucyl-L-threonyl-L-norvalyl- L-isoleucyl-L-arginyl_L- Treatment of soft tissue sarcoma 09.12.2003

N-adamantanyl-N'-Geranyl- ethylenediamine Treatment of tuberculosis. 16.10.2007 natural human lymphoblastoid interferon-alpha Treatment of polycythemia vera 18.11.2002

Natural human lymphoblastoid interferon-alpha Treatment of Behcet's disease. 18.01.2000

Natural human lymphoblastoid Treatment of papillomavirus warts in the oral cavity of interferon-alpha HIV positive patients. 10.08.2000

NDROGE Treatment of postanoxic intention myoclonus. 01.11.1984

Treatment of patients with gram-negative bacteremia Nebacumab Centoxin which has progressed to endotoxin shock. 01.10.1986 Treatment of motor neuron disease/amyotrophic lateral Neurotrophin-1 sclerosis. 13.09.1994 Diagnostic measure of the capacity of the pituitary NG-29 Somatrel gland to release growth hormone. 08.08.1989

Nifedipine Treatment of interstitial cystitis. 13.06.1991

Nikkomycin Z Treatment of coccidioidomycosis 14.02.2006 nilotinib Tasigna Treatment of gastrointestinal stromal tumors. 20.03.2007

Nimotuzumab Treatment of glioma 17.11.2004 niprisan Hemoxin Treatment of sickle cell disease 15.08.2003 nitazoxanide Cryptaz Treatment for intestinal amebiasis 23.10.2001

Nitisinone Orfadin Treatment of alkaptonuria 19.10.2001 Use in combination with a drug delivery device for acute treatment of sickle cell vaso-occlusive crisis (pain nitric oxide INOmax (r) crises) 05.09.2008

Nitric oxide Diagnosis of sarcoidosis 16.02.2005

To reduce the risk of chronic lung disease in premature Nitric oxide INOmax neonates 27.09.2004

Treatment of acute respiratory distress syndrome in Nitric oxide adults. 10.07.1995

Treatment and prevention of cerebral vasospasm Nitroprusside following subarachnoid hemorrhage. 21.02.2001

N-malonyl-bis(N'-methyl-N'- Treatment of metastatic melanoma in combination with thiobenzoylhydrazide) paclitaxel 18.12.2007 N-Methyl-2-[3-[((E)-2-pyridin-2-yl- Treatment of follicular, medullary and anaplastic thyroid vinyl)-1H-indazol-6- carcinoma and metastatic or locally advanced papillary ylsulfanyl]benzamide Axitinib thyroid cancer. 04.05.2007 Novel Acting Thrombolytic (NAT) Treatment of peripheral arterial occlusion (PAO) 26.01.2001

Nucleic acid aptamer binding to tumor cell nucleolin Treatment of pancreatic cancer 17.08.2004 Nucleic acid aptamer binding to tumor cell nucleon Treatment of renal cell carcinoma 28.07.2005 Enzyme replacement therapy in patients with all patients with all subtypes of NZ-1002 subtypes of Mucopolysaccharidosis I. Mucopolysaccharidosis I. 11.04.2001

Obatoclax mesylate Treatment of chronic lymphocytic leukemia 08.10.2004

Obatoclax mesylate Treatment of myelodysplastic syndrome 06.11.2006

Obatoclax mesylate Treatment of myelofibrosis 01.12.2006 oblimersen Genasense Treatment of acute myelocytic leukemia 28.08.2001 oblimersen Genasense Treatment of multiple myeloma 28.08.2001 oblimersen Genasense Treatment of chronic lymphocytic leukemia 28.08.2001

Treatment of advanced malignant melanoma (Stages oblimersen Genasense II,III, IV). 31.07.2000 ofatumumab Treatment of chronic lymphocytic leukemia 10.03.2009 oglufanide disodium Treatment of ovarian cancer 24.09.2001

OM 401 Drepanol Prophylactic treatment of sickle cell disease. 24.10.1991 omacetaine mepesuccinate Treatment of myelodysplastic syndromes 12.01.2009 Omacetaxine mepesuccinate Treatment of chronic myelogenous leukemia 10.03.2006 Omega-3 (n-3) polyunsaturated fatty acid with all double bonds in the cis configuration Prevention of organ graft rejection. 22.11.1995

Omega-3 (n-3) polyunsaturated fatty acids Omacor Treatment of IgA nephropathy. 04.05.2000 Treatment of parenteral nutrition-associated liver Omegaven emulsion Omegaven disease 27.02.2008 omigapil Treatment of congenital muscular dystrophy. 24.06.2008 oncophage Treatment of glioma 14.04.2009

Oncorad Ov103 Treatment of ovarian cancer. 24.04.1990

oral unfractionated heparin Treatment of familialsickle cell amyotrophic disease lateral sclerosis 29.01.2004 associated with a mutation of the gene (on chromosome 21q) for copper, zinc superoxide Orgotein for injection dismutase. 22.12.1994

Oxaliplatin Treatment of ovarian cancer. 06.10.1992

Oxalobacter formigenes Treatment of primary hyperoxaluria 29.03.2006

Treatment of short stature associated with Turner's Oxandrolone Oxandrin syndrome. 05.07.1990

Oxandrolone Treatment of constitutional delay of growth and puberty. 05.10.1990

Treatment of patients with Duchenne's muscular Oxandrolone Oxandrin dystrophy and Becker's muscular dystrophy. 22.04.1997

Adjunctive therapy for AIDS patients suffering from HIV- Oxandrolone Oxandrin wasting syndrome. 06.09.1991 Treatment of moderate/severe acute alcoholic hepatitis in the presence of moderate protein calorie Oxandrolone Hepandrin malnutrition. 18.03.1994

For relief of severe intractable pain in narcotic-tolerant Oxymorphone Numorphan H.P. patients. 19.03.1985

Treatment of hyperuricemia in patients intolerant to Oxypurinol allopurinol. 09.11.1998 p1-(uridine 5'-)-p4-(2'- deoxycytidine 5'-) tetraphosphate, tetrasodium salt For the treatment of cystic fibrosis 07.03.2001

P1, P4-Di(uridine 5'- tetraphosphate), tetrasodium salt Treatment of cystic fibrosis. 27.10.1998 paclitaxel Treatment of pancreatic cancer 01.05.2009

Paclitaxel Paxene Treatment of AIDS-related Kaposi's sarcoma. 15.04.1997 paclitaxel aqueous gel OncoGel (tm) Treatment of brain cancer. 23.12.2008 paclitaxel aqueous gel OncoGel(tm) Treatment of esophageal cancer 01.02.2008 paclitaxel, micellar Paclical Treatment of ovarian cancer

Treatment of human African trypanosomiasis (sleeping Pafuramidine maleate sickness) 31.08.2007

Pafuramidine maleate Treatment of malaria 14.05.2007 pafuramidine maleate Treatment of pneumocystis jiroveci pneumonia 17.11.2006

Palifosfamide Treatment of soft tissue sarcomas 05.05.2008

Panobinostat Faridak Treatment of cutaneous T-cell lymphoma 26.09.2007 Papain, trypsin, and chymotrypsin Wobe-Mugos Treatment of multiple myeloma. 21.12.1998 parathyroid hormone Treatment of hypoparathyroidism. 31.08.2007 paromomycin sulfate/gentamicin Treatment of non-complicated Old World cutaneous sulfate leishmaniasis 18.01.2008 Parvovirus B19 (recombinant VP1 and VP2; S.frugiperda cells) Prevention of transient aplastic crisis in patients with vaccine MEDI-491 sickleTreatment cell anemia.of patulous eustachian tube. 07.05.1999

Patul-end 18.02.1997

Patupilone Treatment of ovarian cancer. 04.10.2005 For use as chronic enzyme replacement therapy in patients with Gaucher's disease who are deficient in PEG-glucocerebrosidase Lysodase glucocerebrosidase. 09.12.1992

Peginterferon alfa-2a PEGASYS Treatment of chronic myelogenous leukemia. 30.09.1999

Peginterferon alfa-2a PEGASYS Treatment of renal cell carcinoma. 13.07.1998

Treatment of malignant melanoma stages IIb through peginterferon alfa-2b PegIntron IV. 09.04.2008

Treatment of primary immunodeficiencies associated PEG-interleukin-2 with T-cell defects. 01.02.1990

Pegylated arginine deiminase Melanocid Treatment of invasive malignant melanoma. 12.04.1999

Pegylated arginine deiminase Hepacid Treatment of hepatocellular carcinoma. 26.03.1999 Pegylated recombinant human megakaryocyte growth and For reducing the period of thrombocytopenia in patients development factor MEGAGEN undergoing hematopoietic stem cell transplantation. 20.10.1997

Peldesine Treatment of cutaneous T-cell lymphoma. 05.10.1993 Pentamidine isethionate Treatment of Pneumocystis carinii pneumonia. 29.10.1984 Pentamidine isethionate Prevention of Pneumocystis carinii pneumonia in (inhalation) Pneumopent patients at high risk of developing this disease. 05.10.1987

Treatment of patients with known or suspected internal pentetate trisodium diethylenetriaminepentacontamination with plutonium, americium, or curium. 12.04.2004 pentosan polysulfate sodium Treatment of sickle cell disease. 21.11.2008

Treatment of patients with chronic lymphocytic Pentostatin Nipent leukemia. 29.01.1991

Pentostatin Nipent Treatment of peripheral T-cell lymphomas. 24.11.1999

Pentostatin Nipent Treatment of cutaneous T-cell lymphoma. 27.03.1998

Peptide 144 TGF beta-1 inhibitor Treatment of systemic sclerosis 27.04.2006

Peptide 144 TGF beta-1-inhibitor Treatment of localized scleroderma 26.04.2006

Peptidomimetic analog of hexarelin Diagnosis of growth hormone deficiency 14.05.2007 Treatment of acute respiratory distress disease (ARDS) Perflubron LiquiVent Forin adults use in the ex-vivo treatment of autologous bone 26.04.2001 marrow and subsequent reinfusion in patients with acute myelogenous leukemia, also referred to as acute Perfosfamide Pergamid nonlymphocytic leukemia. 04.12.1989

Pergolide Permax Treatment of Tourette's syndrome. 20.11.1997 For use as an adjunct to surgery, radiation therapy and chemotherapy for the treatment of patients with primary Phenylacetate or recurrent malignant glioma. 06.03.1998

Phenylalanine ammonia-lyase Phenylase Treatment of hyperphenylalaninemia. 08.03.1995 Phenylbutyrate Treatment of acute promyelocytic leukemia. 19.01.2000

Treatment of ileal pouch anal anastomosis related fecal phenylephrine incontinence 14.02.2002

Phosphocysteamine Treatment of cystinosis. 12.09.1988 phosphorothioate antisense olignucleotide against EWS-Fli-1 Treatment of Ewing's sarcoma 22.09.2008 phosphorothioate oligonucleotide Treatment of amyotrophic lateral sclerosis 09.11.2007

Picoplatin Treatment of small cell lung cancer 02.11.2005

Piracetam Nootropil Treatment of myoclonus. 02.10.1987 Treatment of infections caused by Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium- Piritrexim isethionate intracellulare. 13.06.1988 Plasmid DNA vector expressing cystic fibrosis transmembrane gene Treatment of cystic fibrosis 29.03.2005 plasmin (human) Treatment of acute peripheral arterial occlusion (aPAO) 30.03.2009

Plevitrexed Plevitrexed Treatment of ovarian cancer 14.05.2007

Plevitrexed Plevitrexed Treatment of gastric (stomach) cancer 29.05.2007

Plitidepsin Aplidin Treatment of acute lymphoblastic leukemia 18.06.2004

Plitidepsin Aplidin Treatment of multiple myeloma 30.09.2004 Treatment of vasospasm in subarachnoid hemorrhage patients following surgical repair of a ruptured cerebral Poloxamer 188 aneurysm. 05.08.1997 Poloxamer 188 Flocor Treatment of sickle cell crisis. 27.06.1989

Poloxamer 188 Florcor Treatment of severe burns requiring hospitalization. 22.02.1990

Poloxamer 331 Protox Initial therapy of toxoplasmosis in patients with AIDS. 21.03.1991

Poly I: poly C12U Ampligen Treatment of renal cell carcinoma. 20.05.1991

Treatment of invasive metastatic melanoma (stage IIb, Poly I: poly C12U Ampligen III, IV). 09.12.1993

Poly I: poly C12U Ampligen Treatment of chronic fatigue syndrome. 09.12.1993

Poly I: poly C12U Ampligen Treatment of AIDS. 19.07.1988 To control the clinical consequences of hyperuricemia in patients with severe gout in whom conventional Polyethylene glycol (PEG)-uricase therapy is contraindicated or has been ineffective. 21.02.2001 Treatment of hyperuricemia in patients with gout Polyethylene glycol-modified refractory to conventional therapy or in whom uricase conventional therapy is contraindicated 06.06.2005

Polyethylene glycol-modified Prophylaxis of hyperuricemia in cancer patients prone uricase Zurase to develop tumor lysis syndrome during chemotherapy. 14.09.1999

Polyethylene glycol-modified Treatment of tumor lysis syndrome in cancer patients uricase Zurase undergoing chemotherapy. 21.12.1998

Poly-ICLC Hiltonol Treatment of primaryflavivirus brain infections tumors. including those due to 17.03.1997 West Nile, Japanese encephalitis, dengue, St. Louis encephalitis, yellow fever, Murray valley, and Banzai polyinosinic-polycytidilic acid Poly-ICLC viruses 03.03.2003 polyinosinic-polycytidilic acid Poly-ICLC As an adjuvant to smallpox vaccination 02.08.2002 polyinosinic-polycytidilic acid (Poly- ICLC) Hiltonol Treatment for orthopox virus infections 19.11.2002

Polymeric oxygen Treatment of sickle cell anemia. 25.03.1992 polyphenon E Treatment of chronic lymphocytic leukemia 17.07.2008

Polyvalent, shed-antigen melanoma vaccine Treatment of stage IIb to stage IV melanoma 09.06.2006 Porcine fetal neural dopaminergic Treatment of Hoehn and Yahr stage 4 and 5 cells and/or precursors aseptically NeuroCell-PD Parkinson's disease. 17.12.1996 Porcine fetal neural dopaminergic Treatment of Hoehn and Yahr stage 4 and 5 cells and/or precursors aseptically NeuroCell-PD Parkinson's disease. 17.12.1996 Porcine fetal neural gabaergic cells and/or precursors aseptically prepared and coated with anti- NeuroCell-HD Treatment of Huntington's disease. 10.12.1996 Porcine fetal neural gabaergic cells and/or precursors aseptically prepared for intracerebral NeuroCell-HD Treatment of Huntington's disease. 10.12.1996 Porcine Sertoli cells aseptically prepared for intracerebral co- Treatment of Hoehn and Yahr stage four and five implantation with fetal neural N-Graft Parkinson's disease. 24.06.1997

Porfimer sodium Photofrin Treatment of cholangiocarcinoma 18.11.2004

For the photodynamic therapy of patients with Porfimer sodium Photofrin transitional cell carcinoma in situ of the urinary bladder. 15.11.1989

Porfiromycin Promycin Treatment of cervical cancer. 13.03.1997

Porfiromycin Promycin Treatment of head and neck cancer. 19.09.1995

Posaconazole Posoril Treatment of zygomycosis 16.07.2004

For the dissolution and control of uric acid and cysteine Potassium citrate and citric acid calculi in the urinary tract. 14.02.1986 potassium sodium aluminosilicate For treatment of poisoning by or exposure to cesium. 08.01.2007 Treatment of myelodysplastic syndromes requiring PR1 Vaccine therapy 03.09.2004

PR1 Vaccine Treatment of acute myelogenous leukemia 03.09.2004

PR1 Vaccine Treatment of chronic myelogenous leukemia. 03.09.2004

For the emergency rescue treatment of status Pr-122 (redox-phenytoin) epilepticus, grand mal type. 05.07.1990

Treatment of herpes simplex encephalitis in individuals PR-225 (redox-acyclovir) afflicted with AIDS. 29.05.1990

PR-239 (redox penicillin G) Treatment of AIDS associated neurosyphilis. 23.05.1990

Pr-320 (molecusol- For the emergency rescue treatment of status carbamazepine) epilepticus, grand mal type. 20.07.1990

pralatrexate Treatment of diffuse large B-cell lymphoma 20.10.2008 pralatrexate Treatment of follicular lymphoma 20.10.2008 pralatrexate Treatment of T-cell lymphoma 20.07.2006 pramipexole Mirapex Treatment of Tourette's syndrome in pediatric patients 31.01.2008 For the management of cognitive dysfunction and enhancement of antidepressant activity associated with Pramiracetam Sulfate electroconvulsive therapy. 04.11.1991

Praziquantel Treatment of neurocysticercosis. 18.04.1988

Prednimustine Sterecyt Treatment of malignant non-Hodgkin's lymphomas. 17.06.1985 For use in combination with clindamycin hydrochloride in the treatment of Pneumocystis carinii pneumonia Primaquine phosphate associated with AIDS. 23.07.1993 Procarbazine HCl Matulane Treatment of malignant glioma 08.08.2006 Establishment and maintenance of pregnancy in women undergoing in vitro fertilization or embryo Progesterone transfer procedures. 22.12.1994

Propamidine isethionate 0.1% ophthalmic solution Brolene Treatment of acanthamoeba keratitis. 10.03.1988

Treatment of proliferating infantile hemangiomas propanolol requiring systemic therapy 05.09.2008

Prostaglandin E1 enol ester (AS- Treatment of Fontaine Stage IV chronic critical limb 013) Circulase ischemia. 12.06.1998

Treatment of ischemic ulceration of the lower limbs due Prostaglandin E1 in lipid emulsion Lipo-PGE1 to peripheral arterial disease. 10.09.1996

Protaxel Treatment of ovarian cancer 21.05.2003

For use in the prevention and treatment of purpura Protein C concentrate Protein C ConcentrateForfulminans replacement in meningococcemia. therapy in patients with congenital or 22.04.1993 acquired protein C deficiency for the prevention and treatment of warfarin-induced skin necrosis during oral Protein C concentrate Protein C Concentrateanticoagulation. 19.06.1992

Prevention of infant respiratory distress syndrome Protirelin associated with prematurity. 24.08.1993

Protirelin injection Treatment of amyothrophic lateral sclerosis. 10.01.1985 Prevention and treatment of infant respiratory distress Pulmonary surfactant replacement syndrome. 05.12.1988 purified bovine type collagen Treatment of idiopathic pulmonary fibrosis 27.04.2009

Purified extract of Pseudomonas Treatment of immune thrombocytopenia purpura where aeruginosa ImmuDyn it is required to increase platelet counts. 22.09.1997

Purified type II collagen Colloral Treatment of juvenile rheumatoid arthritis. 09.02.1995 Pyruvate Treatment of interstitial lung disease. 21.02.2001 For prevention of recurrence of pneumothorax in Quinacrine hydrochloride patients at high risk of recurrence. 17.10.1984 quinine sulfate Treatment of malaria excluding Plasmodium faliparum 02.12.2008

R-(-)-gossypol Treatment of chronic lymphocytic leukemia. 24.10.2006 R-4-amino-3-(4- Treatment of the behavorial abnormalities associated chlorophenyl)butanoic acid with fragile X syndrome. 28.11.2008 rAAV2-CB-hRPE65 Treatment of type II Leber's Congential Amaurosis 11.02.2005 Induction treatment to prevent rejection and to minimize Rabbit anti-human thymocyte maintenance immunosupression in pediatric liver globulin (rATG) Thymoglobulin transplant recipients 26.09.2006 ranprinase Onconase Treatment of malignant mesothelioma 25.01.2007

Rapamycin Treatment of tuberous sclerosis complex 20.03.2007

Rapamycin (mTOR) inhibitor Treatment of bone sarcoma 09.08.2005 raxibacumab Abthrax Treatment of anthrax 12.11.2003 recombinant adeno-associated virus alpha 1-antitrypsin vector rAAV-AAT Treatment of alpha1-antitrypsin deficiency 27.01.2003

Recombinant anti-CD22 Treatment of CD22-positive chronic lymphocytic immunotoxin leukemia 15.11.2007

Recombinant anti-CD22 immunotoxin Treatment of hairy cell leukemia 15.11.2007

Recombinant anti-CD40 monoclonal antibody Treatment of chronic lymphocytic leukemia 12.08.2005 Recombinant anti-CD-40 monoclonal antibody Treatment of multiple myeloma 25.01.2006 Recombinant bactericidal/permeability- increasing protein Neuprex Treatment of severe meningococcal disease. 22.06.1998 recombinant chimeric monoclonal antibody to anthrax Anthim Treatment of exposure to B. anthracis spores 09.06.2006 Recombinant coagulation factor VIIa Novoseven Treatment of diffuse alveolar hemorrhage 26.04.2006

Recombinant deriative of C3 transferase Cethrin Treatment of acute spinal cord injury 18.11.2005 Recombinant disintegrin and Treatment of thrombotic thrombocytopenic purpura metalloprotease with including its congential, acquired idiopathic, and thrombospondin type 1 motifs secondary forms. 29.07.2008 Recombinant disintegrin and Prevention of thrombotic thrombocytopenic purpura metalloprotease with including its congential, acquired idiopathic and thrombospondin type 1 motifs secondary forms. 29.07.2008 Prevention of post-transplantation lymphoproliferative Recombinant Epstein-Barr virus disorders in pediatric recipients of solid-organ gp350 glycoprotein vaccine transplantation 18.08.2005 Recombinant fully human monoclonal antibody to anthrax protective antigen Valortim Treatment of anthrax infection 16.02.2006 recombinant fusion protein with a Treatment of Ep-CAM-positive squamous cell truncated form of the cytotoxic carcinoma of the head and neck protein Pseudomonas exotoxin Proxinium 28.01.2005 Recombinant glycine2-human glucagon-like peptide-2 Treatment of short bowel syndrome. 29.06.2000 Recombinant human alpha 1- antitrypsin Prevention of bronchopulmonary dysplasia 28.04.2005 recombinant human alpha 1- antitrypsin (rAAT) Treatment of cystic fibrosis 20.11.2001 recombinant human alpha-1 antitrypsin Treatment of cystic fibrosis. 06.03.1998 To delay progression of chronic obstructive pulmonary recombinant human alpha-1 disease resulting from AAT deficiency-mediated antitrypsin (rAAT) emphysema and bronchiectasis 28.08.2001

Recombinant Human Alpha- Fetoprotein (rhAFP) Treatment of myasthenia gravis 22.02.2001 Recombinant human alpha- mannosidase Treatment of alpha-mannosidosis 02.02.2006 Recombinant human anti-GDF-8 (growth and differentiation factor- Treatment of Duchenne and Becker muscular 8) antibody dystrophies 16.02.2005 Recombinant human antithrombin Treatment of antithrombin III dependent heparin III resistance requiring anticoagulation. 06.04.2000 recombinant human arylsulphatase A Treatment of metachromatic leukodystrophy (MLD). 11.04.2008

Recombinant human C1 inhibitor Treatment of capillary leakage syndrome 09.06.2006 Prevention and/or treatment of delayed graft function Recombinant human C1 inhibitor after solid organ transplantation 09.06.2006

Recombinant human C1-esterase Treatment of (acute attacks of) angioedema caused by inhibitor hereditary or acquired C1-esterase inhibitor deficiency. 23.02.1999 Recombinant human C1-esterase Prophylactic treatment of angioedema caused by inhibitor hereditary or acquired C1-esterase inhibitor deficiency. 23.02.1999 Recombinant human CD4 immunoglobulin G Treatment of AIDS resulting from infection with HIV-1. 30.08.1990

Recombinant human Clara Cell Prevention of neonatal bronchopulmonary dysplasia in 10kDa protein premature neonates with respiratory distress syndrome. 13.07.1998 For the control and prevention of hemorrhagic episodes recombinant human coagulation in patients with hemophilia B (congential factor IX factor IX fusion protein deficiency or Christmas disease). 30.10.2008

Recombinant human endostatin protein Treatment of neuroendocrine tumors 13.08.2001 recombinant human endostatin protein Treatment of metastatic melanoma 21.02.2002

Recombinant human fibrinogen Treatment of bleeding in patients deficient in fibrinogen 04.10.2007 recombinant human fibroblast growth factor-20 Treatment of radiation induced oral mucositis 29.01.2004

Treatment of acute and chronic respiratory symptoms Recombinant human gelsolin of bronchiectasis. 06.03.1995 Treatment of the respiratory symptoms of cystic Recombinant human gelsolin fibrosis. 12.01.1994

Recombinant human granulocyte colony stimulating factor Prevention of implantation failure 24.07.2006

Recombinant human highly For enzyme replacement therapy in patients with all phosphorylated acid alpha- subtypes of glycogen storage disease type II (GSDII, glucosidase TBD Pompe Disease) 20.09.2000 recombinant human histone H1.3; recombinant human N-bis-met- histone H1.3 Oncohist (r) Treatment of acute myeloid leukemia 20.10.2008

Recombinant human insulin-like growth factor 1 IGF-1 Treatment of growth hormone receptor deficiency. 07.06.1995 Treatment of antibody-mediated growth hormone Recombinant human insulin-like resistance in patients with isolated growth hormone growth factor 1 IGF-1 Treatmentdeficiency Ia.of short-bowel syndrome as a result of 07.06.1995 Recombinant human insulin-like resection of the small bowel or as a result of congenital growth factor-I PV802 dysfunction of the intestines. 16.02.2000

Recombinant human insulin-like growth factor-I Treatment of post-poliomyelitis syndrome. 13.10.1995 Recombinant human insulin-like growth factor-I/insulin-like growth factor binding protein-3 Treatment of major burns that require hospitalization. 15.06.1999

Recombinant human interleukin- 12 Treatment of renal cell carcinoma. 20.10.1997

Recombinant Human Interleukin- Treatment of stage II (T4), III or IV malignant 21 (rIL-21) melanoma. 04.10.2005

Recombinant human keratinocyte Reducing the incidence and severity of radiation- growth factor induced xerostomia. 20.12.1999 Recombinant human lysosomal acid lipase or cholesteryl ester Treatment of lipase deficiencies, including Wolman hydrolase Cholestrase Disease and cholesteryl ester storage disease 14.07.2005

Recombinant human microplasmin Treatment of peripheral arterial occlusion 23.01.2006 recombinant human minibody Treatment of primary membranoproliferative against complement component MUBODINA glomerulonephritis 04.02.2009 recombinant human minibody against complement component Prevention of ischemmia/reperfusion injury associated C5 fused with RGD-motif with solid organ transplantation. 04.02.2009 recombinant human monoclonal antibody to hsp90 Mycograb Treatment of invasive candidiasis 16.09.2002 Recombinant human nerve growth factor Treatment of HIV-associated sensory neuropathy. 16.04.1999 recombinant human neutrophil inhibitor (hNE) Treatment of cystic fibrosis 09.12.2003

Recombinant human platelet derived growth factor BB Treatment of osteonecrosis of the jaws 01.02.2007 recombinant human porphobilinogen deaminase Porphozyme Treatment of acute intermittent porphyria attacks 09.09.2002 recombinant human porphobilinogen deaminase, Treatment of acute intermittent porphyria preventing erythropoetic form attacks 11.07.2002 recombinant human proinsulin Treatment of retinitis pigmentosa 10.12.2008

Recombinant human relaxin Treatment of progressive systemic sclerosis. 03.11.1995 recombinant human rod-derived cone viability factor Treatment of retinitis pigmentosa 07.01.2008 Recombinant human For use in accelerating platelet recovery in patients thrombopoietin Preventionundergoing ofhematopoietic arteriovenous stem fistula cell maturation transplantation. and 29.09.1997 arteriovenous graft failure in patients with end stage recombinant human type I renal disease who are receiving hemodialysis or pancreatic elastase preparing for hemodialysis 03.04.2009 recombinant human type VII Treatment of hereditary dystrophic epidermolysis collagen bullosa (DEB) 18.06.2008

Recombinant humanized MAb 5c8 Prevention of rejection of solid organ transplants. 22.03.1999 Prevention of rejection of pancreatic islet cell Recombinant humanized MAb 5c8 transplants. 22.03.1999

Prevention and treatment of Factor VIII/Factor IX Recombinant humanized MAb 5c8 inhibitors in patients with hemophilia A or B. 14.10.1998

Recombinant humanized monclonal antibody 5c8 Treatment of immune thrombocytopenic purpura. 03.02.1998

Recombinant humanized monoclonal antibody 5c8 Treatment of systemic lupus erythematosus. 18.02.1998

Recombinant methionyl brain- derived neurotrophic factor Treatment of amyotrophic lateral sclerosis. 28.11.1994 recombinant ovine interferon tau Tauferon Treatment of pediatric multiple sclerosis 25.01.2005 Recombinant Porcine Factor VIII, patients with inhibitor antibodies to human coagulation B-domain Deleted factor VIII 16.03.2004

Recombinant P-Selectin Prevention of delayed graft function in renal transplant glycoprotein ligand patients 29.03.2006 Recombinant P-selectin Prevention of ischemia reperfusion injury in all solid glycoprotein ligand- organ transplants 26.07.2007

Recombinant retroviral vector - For use as enzyme replacement therapy for patients glucocerebrosidase with types I, II, or III Gaucher disease. 15.11.1993

Recombinant secretory leucocyte protease inhibitor Treatment of cystic fibrosis. 29.03.1991

Recombinant secretory leucocyte protease inhibitor Treatment of congenital alpha-1 antitrypsin deficiency. 29.03.1991

Recombinant soluble human CD4 Receptin Treatment of acquired immunodeficiency syndrome. 20.11.1989

Recombinant soluble human CD4 (rCD4) Treatment of AIDS in patients infected with HIV virus. 23.03.1989 Treatment of multiple sclerosis patients who are both Recombinant T-cell receptor HLA-DR2 positive and autoreactive to myelin ligand oligodendrocyte glycoprotein residues 35-55 02.05.2003 Recombinant truncated SPINT2 protease inhibitor Treatment of cystic fibrosis 24.06.2005

Recombinant urate oxidase Prophylaxis of chemotherapy-induced hyperuricemia. 11.10.2000

Reduced L-glutathione Cachexon Treatment of AIDS-associated cachexia. 14.02.1994

Remacemide Ecovia Treatment of Huntington's disease. 06.03.2000

Prevention of delayed graft function in solid organ Reparixin transplant 27.01.2003 repository corticotropin or adrenocorticotropic hormone H.P. Acthar Gel Treatment of infantile spasms 21.05.2003 resiniferatoxin Treatment of intractable pain at end-stage disease 13.05.2003 reslizumab Treatment of children with eosinophilic esophagitis 19.12.2007 Treatment of respiratory syncytial virus lower Respiratory Syncytial Virus respiratory tract infections in hospitalized infants and Immune Globulin (human) Hypermune RSV young children. 27.09.1990 retaspimycin Treatment for gastrointestinal stromal tumor 31.08.2007 retaspimycin hydrochloride Treatment of melanoma stages IIb through IV. 24.06.2008

R-etodolac Treatment of chronic lymphocytic leukemia 09.12.2002 retroviral gamma-c cDNA Treatment of X linked severe combined immune containing vector deficiency disease 29.04.2002

Retroviral vector, R-GC and GC gene 1750 Treatment of Gaucher disease. 06.05.1997

Treatment of deep vein thrombosis which may lead to Reviparin sodium Clivarine pulmonary embolism in pediatric patients 18.06.2001

Long-term treatment of acute deep vein trombosis with Reviparin sodium Clivarine or without pulmonary embolism in pregnant patients 18.06.2001 RGG0853, E1A lipid complex Treatment of extremeovarian cancer. insulin resistance syndromes 15.09.1995 (type A, Rabson-Mendenhall syndrome, rhIGF-I/rhIGFBP-3 SomatoKine Leprechaunism, Type B syndrome) 09.12.2003 rh-microplasmin Adjunct to surgery in cases of pediatric vitrectomy 16.03.2004

Ribavirin Virazole Treatment of hemorrhagic fever with renal syndrome. 12.04.1991 For the ex-vivo purging of leukemic cells from the bone Ricin (blocked) conjugated murine marrow of non-T cell acute lymphocytic leukemia mca (anti-b4) patients who are in complete remission. 24.01.1991

Ricin (blocked) conjugated murine MCA (anti-B4) Treatment of B-cell leukemia and B-cell lymphoma. 17.11.1988

Ricin (blocked) conjugated murine Treatment of myeloid leukemia, including AML, and MCA (anti-my9) blast crisis of CML. 03.08.1989 For use in the ex-vivo treatment of autologous bone Ricin (blocked) conjugated murine marrow and subsequent reinfusion in patients with MCA (anti-my9) acute myelogenous leukemia. 01.02.1990

Ricin (blocked) conjugated murine MCA (n901) Treatment of small cell lung cancer 25.01.1991 Treatment of cutaneous T-cell lymphomas, acute T-cell Ricin (blocked) conjugated murine leukemia-lymphoma, and related mature T-cell monoclonal antibody (CD6) malignancies. 06.09.1994

Treatment of disseminated Mycobacterium avium Rifabutin complex disease. 18.12.1989

Rifalazil ProphylacticTreatment of treatmentpulmonary of tuberculosis. Mycobacterium avium 13.04.1999 complex in patients with AIDS and a CD4+ count less Rifapentine Priftin than or equal to 75/mm3. 12.03.1996

Treatment of Mycobacterium avium complex in patients Rifapentine Priftin with AIDS. 09.06.1995

Rifaximin Normix Treatment of hepatic encephalopathy 10.02.1998

RII retinamide Treatment of myelodysplastic syndromes. 06.05.1993 Riluzole Rilutek Treatment of Huntington's disease. 15.10.1996

risedronate sodium Actonel Treatment of patients with osteogenesisanti-neutrophil imperfecta. cytoplasmic 18.12.2006 antibody-associated vasculitis (Wegener's Granulomatosis, Microscopic Polyangiitis, and Churg- rituximab Rituxan Strauss Syndrome) 14.02.2006 rituximab Rituxan Treatment of immune thrombocytopenic purpura 12.03.2002 rituximab Rituxan Treatment of chronic lymphocytic leukemia 29.01.2004 RNA, ((2',3'-dideoxy-2',3'-imino- 2',3'- seco)[dimethylamino)phosphinylid Treatment of Duchenne Muscular Dystrophy. 23.10.2007 rofecoxib Vioxx Treatment of juvenile rheumatoid arthritis 16.03.2004 romidepsin Treatment of non-Hodgkin T-cell lymphomas 30.09.2004 To prolong time to relapse in leukemia patients who have undergone autologous bone marrow Roquinimex Linomide transplantation. 01.07.1993

Rose Bengal Disodium Treatment of metastatic melanoma 20.12.2006 rSP-C lung surfactant Venticute Treatment of adult respiratory distress syndrome. 03.04.2000 For use in patients with pneumonia or aspiration of gastric contents leading to intubation, mechanical rSP-C surfactant Venticute Treatmentventilation, ofand pediatric severe patients oxygen infectedimpairment with human 18.09.2006 immunodeficiency virus and acquired immunodeficiency rubitecan syndrome 17.07.2002 S(-)-3-[3-amino-phthalimido]- glutaramide Treatment of multiple myeloma 14.03.2002

S-adenosylmethionine Treatment of AIDS-myelopathy. 30.04.1998 salirasib Treatment of panreatic cancer. 18.12.2006 sarsasapogenin Treatment of amyotrophic lateral sclerosis (ALS) 18.06.2004

SB-408075 For pancreatic cancer 07.12.2000

Treatment of patients with CD55 (sc-1) positive gastric SC-1 monoclonal antibody tumors 12.11.2003

SCH 58500 Treatment of primary ovarian cancer. 12.04.1999

SDF-1 (108) Lysine Dlmer Treatment of osteogenic sarcoma 07.07.2005

Secalciferol Osteo-D Treatment of familial hypophosphatemic rickets. 26.07.1993 Secretory leukocyte protease inhibitor Treatment of bronchopulmonary dysplasia. 30.06.1992

Seneca Valley virus Treatment of neuroendocrine tumors Treatment of neuroendocrine tumors 22.08.2008 ovulation in women with anovulatory or oligo-ovulatory Sermorelin acetate Geref infertility who fail to ovulate in response to adequate 13.02.1990

Sermorelin acetate Geref Treatment of AIDS-associated catabolism/weight loss. 05.12.1991 Serratia marcescens extract (polyribosomes) Imuvert Treatment of primary brain malignancies. 07.09.1988

SGN-30 (anti-CD30 antibody) Treatment of CD30 positive T-cell lymphomas 18.02.2004

SGN-30 (anti-CD30 mAb) Treatment of Hodgkin's disease 18.07.2003

SGN-35 (cAC10-vcMMAE(4)) Treatment of anaplastic large cell lymphoma 23.10.2008

SGN-40 (anti-CD40 antibody) Treatment of multiple myeloma. 13.08.2004

Short chain fatty acid enema Colomed Treatment of chronic radiation proctitis. 19.08.1997 Treatment of the active phase of ulcerative colitis with Short chain fatty acid solution Colomed involvement restricted to the left side of the colon. 29.05.1990

Silver sulfadiazine and cerium nitrate Flammacerium Prevention of mortality in severely burned patients. 17.11.1999

siplizumab Treatment of T-cell lymphomas 15.07.2003

For the treatment of pulmonary arterial hypertension in the absence of chronic obstructive pulmonary disease Sitaxsentan Sodium or congestive heart failure. 02.11.2004 For the long term treatment of children who have growth failure due to a lack of adequate endogenous SK&F 110679 growth hormone secretion. 23.05.1990

sodium 2, 2 dimethylbutyrate Treatment of sickle cell disease. 25.07.2008 sodium 4-{ [9-chloro-7-(2-fluoro-6- methoxyphenyl)-5H-pyrimido [5,4- d] [2] benzazepin-2-yl]-2- Treatment of ovarian cancer 03.04.2009

Sodium aluminosilicate Treatment of chronic hepatic encephalopathy 04.03.2005 Treatment of metastatic or locally advanced inoperable Sodium ascorbate and menadione transitional cell carcinoma of the urothelium (stage III sodium bisulfite Apatone and IV bladder cancer) 31.07.2007

Treatment of homozygous familial Sodium dichloroacetate hypercholesterolemia. 11.06.1990

Sodium dichloroacetate Treatment of congenital lactic acidosis. 11.06.1990

Sodium dichloroacetate Treatment of congenital lactic acidosis. 31.12.1997

Treatment of lactic acidosis in patients with severe Sodium dichloroacetate malaria. 10.11.1994

Use as an antidote in the management of systemic sodium dichloroacetate monochloroacetic acid poisoning 03.07.2003 Sodium dichloroacetate Ceresine Treatment of severe head injury. 14.06.1999 Sodium Monomercaptoundecahydro-closo- For use in boron neutron capture therapy (BNCT) in the dodecaborate Borocell treatment of glioblastoma multiforme. 15.04.1992 Sodium For use in conjunction with a thermal or epithermal monomercaptoundecahydro-closo- neutron beam in boron nuclear capture therapy of dodecaborate glioblastoma multiforme. 18.12.1984 Treatment of vaso-occlusive crisis associated with Sodium nitrite sickle cell disease 02.04.2007

Sodium nitrite Treatment of cyanide poisoning 18.04.2007

Prevention of vasospasm associated with subarachnoid Sodium nitrite hemorrhage 17.01.2007

sodium nitrite Treatment of pulmonary arterial hypertension 08.07.2008

Sodium nitrite and sodium thiosulfate Cyanide Antidote Kit Treatment of known or suspected cyanide poisoning 09.04.2008

Sodium nitrite/sodium thiosulfate Cyanide Antidote PackaTreatment of cyanide poisoning 23.03.2007

Sodium phenylacetate/sodium benzoate 10%/10% Injection Ammonul Treatment of grade III and IV hepatic encephalopathy 03.06.2005

Sodium phenylbutyrate Treatment of spinal muscular atrophy 20.03.2007

Sodium phenylbutyrate Buphenyl Treatment of spinal muscular atrophy 25.01.2007 For use as an adjuct to surgery, radiation therapy and chemotherapy for the treatment of patients with primary Sodium phenylbutyrate Treatmentor recurrent for malignant sickling disorders,glioma. which include S-S 24.04.1998 hemoglobinopathy, S-C hemoglobinopathy, and S- sodium phenylbutyrate thalassemia hemoglobinopathy. 02.07.1992

Sodium pyruvate Treatment of cystic fibrosis 31.03.2003 Sodium stibogluconate Treatment of cutaneous leishmaniasis 16.06.2006

Prevention of platinum-induced ototoxicity in pediatric Sodium thiosulfate patients 17.03.2004

Sodium thiosulfate and sodium nitrite Treatment of cyanide poisoning 18.12.2006

Sodium thiosulfate, sodium nitrite, amyl nitrite Cyanide Antidote PackaTreatment of cyanide poisoning 16.06.2006

Solasonine and solamargine Coramsine Treatment of renal cell carcinoma 02.11.2005

Treaatment of high risk stage II, stage III and stage IV Solasonine and solamargine Coramsine melanoma 06.02.2006

Soluble complement receptor type Prevention of post-cardiopulmonary bypass syndrome 1 in children undergoing cardiopulmonary bypass. 06.03.2000 Soluble recombinant human Prevention or reduction of adult respiratory distress complement receptor type 1 syndrome. 21.11.1994 Solvent/detergent treated non- blood group specific human coagulation active plasma UNIPLAS Treatment of thrombotic thrombocytopenic purpura 12.12.2005 Adjunct to the non-operative management of secreting cutaneous fistulas of the stomach, duodenum, small Somatostatin Zecnil intestine (jejunum and ileum), or pancreas. 20.06.1988

Somatostatin Treatment of bleeding esophageal varices. 22.12.1994 Treatment of short stature associated with Turner's Somatrem for injection Protropin syndrome. 09.12.1985 Treatment of short stature in pediatric patients with short stature homeobox-containing gene (SHOX) Somatropin Humatrope deficiency 15.12.2005 Treatment of short stature associated with Turner's Somatropin Norditropin Adjunctsyndrome. for the induction of ovulation in women with 05.11.1987 infertility due to hypogonadotropic hypogonadism or Somatropin Norditropin bilateral tubal occlusion or unexplained infertility, who 01.09.1987 Somatropin Biotropin Treatment of cachexia associated with AIDS. 12.02.1993 Treatment of patients with HIV-associated adipose Somatropin Serostim redistribution syndrome 16.03.2004

For the enhancement of nitrogen retention in Somatropin (rDNA) Saizen hospitalized patients suffering from severe burns. 03.05.1989 Treatment of children with AIDS-associated failure-to- Somatropin (r-DNA) for injection Serostim thrive including AIDS-associated wasting. 26.03.1996

Sorafenib Nexavar Treatment of stage IIB through stage IV melanoma 29.09.2006 Treatment of herpes zoster (shingles) in Sorivudine BRAVAVIR immunocompromised patients. 09.11.1995

Prevention of life threatening ventricular Sotalol HCl Betapace tachyarrhythmias. 23.09.1988 spherical carbon adsorbent Treatment of chronic pouchitis 19.12.2007

For symptomatic relief and parasitic cure of chronic Spiramycin Rovamycine cryptosporidiosis in patients with immunodeficiency. 17.10.1984

Treatment of ovarian cancer refractory or resistant to squalamine lactate standard chemotherapy Treatment of ovarian cancer 11.05.2001

SS1(dsFv)-PE38 Treatment of epithelial ovarian cancer 11.02.2002

SS1(dsFv)-PE38 Treatment of malignant mesothelioma 11.02.2002

ST1-RTA immunotoxin (SR Treatment of patients with B-chronic lymphocytic 44163) leukemia. 12.08.1987

ST1-RTA immunotoxin (SR Prevention of acute graft versus host disease in 44163) allogenic bone marrow transplantation. 12.08.1987

Staphylococcus aureus Immune Prophylaxis against Staphylococcus aureus infections Globulin (Human) Altastaph in low birth weight neonates 29.01.2004 Stem and progenitor cells derived For use as hematopoietic support in patients with from ex vivo expanded allogeneic relasped or refractory hematologic malignancies who umbilical cord blood StemEx are receiving high-dose therapy 04.03.2005

Sterile talc Steritalc Treatment of malignant pleural effusion. 08.12.1997

Sterile talc Steritalc Treatment of pneumothorax. 08.12.1997 stiripentol diacomit(r) Treatment of Dravet syndrome 30.10.2008

SU101 Treatment of ovarian cancer. 12.03.1996

SU101 Treatment of malignant glioma. 25.05.1995

Succimer Chemet Treatment of mercury intoxication. 22.03.1991

Prevention of cystine kidney stone formation in patients with homozygous cystinuria who are prone to stone Succimer Chemet development. 05.11.1990

Treatment of oral mucositis and stomatitis following Sucralfate radiation therapy for head and neck cancer. 15.07.1993

Treatment of oral complications of chemotherapy in Sucralfate suspension bone marrow transplant patients. 12.03.1990

Treatment of oral ulcerations and dysphagia in patients Sucralfate suspension with epidermolysis bullosa. 04.03.1991 sulfamidase For treatment of Sanfilippo Syndrome. 22.05.2008

Sulfapyridine ForTreatment protection of dermatitis of donor organherpetiformis. tissue from damage or 10.09.1990 injury mediated by oxygen-derived free radicals that are generated during the necessary periods of ischemia Superoxide dismutase (human) (hypoxia, anoxia), and especially reperfusion, 06.03.1985 Superoxide dismutase (recombinant human) Oxsodrol Prevention of reperfusion injury to donor organ tissue. 17.05.1988

Suramin Metaret Treatment of hormone-refractory prostate cancer. 06.05.1997

Surfactant (human) (amniotic fluid Prevention and treatment of neonatal respiratory derived) Human Surf distress syndrome. 25.03.1987

Synsorb Pk Treatment of verocytotoxogenic E. coli infections. 17.07.1995

Synthetic Human Parathyroid Hormone 1-34 Treatment of hypoparathyroidism 26.01.2001

For use in conjunction with diagnostic procedures (excluding ERCP) for pancreatic disorders to increase Synthetic human secretin pancreatic fluid secretion 18.09.2006

For use in the diagnosis of gastrinoma associated with Synthetic human secretin Zollinger-Ellison syndrome. 16.06.1999 For use in conjunction with diagnostic procedures for pancreatic disorders to increase pancreatic fluid Synthetic human secretin secretion. 07.03.2000

For use in obtaining desquamated pancreatic cells for Synthetic human secretin cytopathologic examination in pancreatic carcinoma. 16.06.1999

For use in the evaluation of exocrine pancreas function. Synthetic human secretin 16.06.1999

For use in obtaining desquamated pancreatic cells for Synthetic porcine secretin cytopathologic examination in pancreatic carcinoma. 18.06.1999

T4 endonuclease V, liposome To prevent cutaneous neoplasms and other skin encapsulated abnormalities in xeroderma pigmentosum. 27.06.1989

Tacrolimus Prograf Prophylaxis of graft-versus-host-disease. 06.04.1998

Tadalafil Cialis Treatment of pulmonary arterial hypertension 18.12.2006 TAK-603 Treatment of Crohn's disease. 13.05.1998

Talactoferrin alfa Treatment of non-small cell lung cancer 08.08.2007 talactoferrin alfa Treatment of renal cell carcinoma 29.09.2006 talactoferrin alfa For the treatment of graft versus host disease 20.08.2003

talactoferrin alfa For the prevention of graft-versus-host disease 20.08.2003 talampanel Treatment of glioma 17.02.2009 talampanel Treatment of amyotrophic lateral sclerosis 24.03.2008

Tamibarotene Treatment of acute promyelocytic leukemia (APL). 11.10.2007

Tanespimycin Treatment of multiple myeloma 09.09.2004 T-cell depleted stem cell enriched cellular product from peripheal b lood stem cells Treatment of chronic granulomatous disease 01.11.2001

TD-K6a.513a.12 ReveKer Treatment of pachyonychia congenita 15.06.2006 Technetium Tc 99m pterotetramide For the identification of ovarian carcinomas. 16.02.2000

Technetium Tc99m anti-melanoma For use in detecting, by imaging, metastases of murine monoclonal antibody Oncotrac Melanoma ImDiagnosticmalignant melanoma. imaging in the evaluation of the extent of 02.06.1987 Technetium Tc99m murine disease in patients with histologically confirmed monoclonal antibody (IgG2a) to B diagnosis of non-Hodgkin's B-cell lymphoma, acute B- cell LymphoScan cell lymphoblastic leukemia (in children and adults), and 07.04.1992 Technetium Tc99m murine Detection of hCG producing tumors such as germ cell monoclonal antibody to hCG Immuraid, hCG-Tc-99mand trophoblastic cell tumors. 07.08.1989 Technetium Tc99m murine Detection of alpha-fetoprotein producing germ cell monoclonal antibody to human AFP-Scan tumors. 01.08.1989 Technetium Tc99m murine monoclonal antibody to human Detection of hepatocellular carcinoma and alpha-fetoprotein Immuraid, AFP-Scan hepatoblastoma. 01.08.1989 Diagnosis or assessment of rejection status in heart, Technetium Tc99m rh-Annexin V Apomate heart-lung, single lung, or bilateral lung transplants. 03.11.2000

Tegafur/gimeracil/oteracil Treatment of gastric cancer 20.07.2006

Treatment of pulmonary infections caused by temocillin sodium Negaban PalliativeBurkholderia treatment cepacia of recurrent, refractory or second 21.04.2004 primary squamous cell carcinomas of the head and neck in patients considered to be incurable with surgery Temoporfin Foscan or radiotherapy. 28.10.1999

Temozolomide Temodal Treatment of newly diagnosed high grade glioma 18.10.2004

Temozolomide Temodal Treatment of advanced metastatic melanoma. 14.10.1998 tenofovir disoproxil fumarate Viread(r) Treatment of pediatric HIV infection. 17.03.2009

terguride Treatment of pulmonary arterial hypertension 01.05.2008

Teriparatide Parathar Treatment of idiopathic osteoporosis. 28.10.1999

Terlipressin Glypressin Treatment of bleeding esophageal varices. 06.03.1986 Fast Track granted by CDER. A rolling NDA submission is planned by Terlipressin (INN) Treatment of Hepatorenal Syndrome the sponsor. 29.10.2004

Treatment of stages IIB, IIC, III, and stage IV tesetaxel melanoma 21.11.2008 tesetaxel Treatment of gastric cancer 22.12.2008 For use as physiologic testosterone replacement in androgen deficient HIV+ patients with an associated Testosterone TheraDerm Testosteronweight loss. 22.09.1997 Testosterone propionate ointment 2% Treatment of vulvar dystrophies. 31.07.1991

Treatment of constitutional delay of growth and puberty Testosterone sublingual in boys. 16.01.1991

Tetrabenazine Treatment of moderate/severe tardive dyskinesia. 12.05.1998

Suppression of thyroid stimulating hormone in patients Tetraiodothyroacetic acid with well-differentiated cancer of the thyroid gland. 01.05.2000

Treatment of adenocarcinoma of the esophagus and Tezacitabine stomach 27.01.2003 TGF(beta)2-specific phosphorothioate antisense oligodeoxynucleotide Oncomun Treatment of malignant glioma 05.06.2002

TGp1PTH1-34 Treatment of solitary (unicameral) bone cysts. 01.02.2007

Thalidomide Thalomid Treatment of myelodysplastic syndrome 27.09.2004

Treatment and prevention of recurrent aphthous ulcers Thalidomide in severely, terminally immunocompromised patients. 15.05.1995

Thalidomide Synovir Treatment of HIV-associated wasting syndrome. 11.03.1996

Thalidomide Thalomid Treatment of Crohn's disease. 06.04.1999

Prevention of graft versus host disease in patients Thalidomide receiving bone marrow transplantation. 19.09.1988

Treatment of graft versus host disease in patients Thalidomide receiving bone marrow transplantation. 19.09.1988

Treatment and maintenance of reactional lepromatous Thalidomide leprosy. 15.11.1988 Treatment of the clinical manifestations of mycobacterial infection caused by Mycobacterium Thalidomide tuberculosis and non-tuberculous mycobacteria. 12.01.1993 Thalidomide Prevention of graft versus host disease. 05.03.1990

Thalidomide Treatment of graft versus host disease. 05.03.1990

Thalidomide Treatment of primary brain malignancies. 27.02.1998

Treatment of severe recurrent aphthous stomatitis in Thalidomide severely, terminally immunocompromised patients. 01.05.1995

Thalidomide Treatment of Kaposi's sarcoma. 29.07.1998 Conditioning treatment prior to hematopoietic stem cell Thiotepa Tepadina transplantation 02.04.2007 Treatment of stage IIb through Stage IV malignant Thymalfasin Zadaxin melanoma 13.03.2006

Thymalfasin Zadaxin Treatment of chronic active hepatitis B. 03.05.1991

Thymalfasin Zadaxin Treatment of DiGeorge anomaly with immune defects. 08.01.1998

Thymalfasin Zadaxin Treatment of hepatocellular carcinoma. 06.03.2000

Thymosin beta 4 ReversalTreatment of of phenylephrine-induced epidermolysis bullosa mydriasis in 28.05.2004 patients who have narrow anterior angles and are at risk of developing an acute attack of angle-closure Thymoxamine HCl glaucoma following mydriasis. 16.11.1987

Tiapride Treatment of Tourette's syndrome. 21.04.1998

Tiazofurin (2-Beta-D-ribofuranosyl- 4-thiazolecarboxamide) Chronic myelogenous leukemia (CML) 27.12.2000 Tilarginine acetate Treatment of cardiogenic shock 11.04.2005

Prevention of access graft disease in hemodialysis tin ethyl etiopurpurin patients 04.11.2003 To improve pulmonary function in conjunction with standard therapy in the management of patients with Tiotropium bromide Spiriva cystic fibrosis 08.01.2008

Tipifarnib Zarnestra Treatment of acute myeloid leukemia 06.07.2004 tirapazamine ForTreatment use in combinationof head and neckwith levo-thyroxine cancer to suppress 23.10.2002 thyroid stimulating hormone in patients with well- differentiated thyroid cancer who are intolerant to Tiratricol Triacana adequate doses of levo-thyroxine alone. 13.08.1991 Tissue repair cells obtained from autologous bone marrow expanded ex vivo with a cell Treatment of osteonecrosis 13.03.2006 Tissue repair cells obtained from autologous bone marrow expanded ex vivo with a cell ForTreatment the secondary of dilated prevention cardiomyopathy (prevention of lesional 25.01.2007 induction) of disorders with UV-A and visible light- induced photosensitivity, specifically Actinic prurigo, Titanium dioxide and bisoctrizole Hydroa vacciniforme, Solar urticara (SU), Chronic 25.05.2005 For the acute and intermittent Treatment of spasticity associated with multiple management of increased muscle Tizanidine HCl Zanaflex sclerosis and spinal cord injury. tone associated with spasticity. 31.01.1994

Treatment of bronchiectasis patients infected with Tobramycin Tobi Pseudomonas aeruginosa. 18.06.1999

Treatment of chronic pulmonary infection due to P. tobramycin liposomal for inhalation Fluidosomes aeruginosa in cystic fibrosis patients 14.04.2009 Treatment of vitamin E deficiency resulting from Tocophersolan oral solution malabsorption due to prolonged cholestatic (vitamin E-tpgs) hepatobiliary disease. 15.04.1988 toralizumab Treatment of immune thrombocytopenic purpura 14.03.2002

Toremifene Treatment of desmoid tumors. 17.08.1993 Tosedostat Treatment of acute myeloid leukemia 10.12.2008 trabectedin Yondelis Treatment of soft tissue sarcoma. 30.09.2004 trabectedin Yondelis Treatment of patients with ovarian cancer 29.03.2005

Tramadol hydrochloride Management of postherpetic neuralgia 26.04.2005

Tramadol hydrochloride Treatment of painful HIV-associated neuropathy 28.01.2005 Treatment of patients undergoing prostatectomy where there is hemorrhage or risk of hemorrhage as a result Tranexamic acid Cyklokapron of increased fibrinolysis or fibrinogenolysis. 23.07.1987

Tranexamic acid Cyklokapron Treatment of hereditary angioneurotic edema. 09.09.1985

Tranilast Rizaben For the treatment of maligant glioma 02.12.2003

Transforming growth factor-beta 2 Treatment of full thickness macular holes. 18.12.1992

Transgenic human alpha 1 Treatment of emphysema secondary to alpha 1 antitrypsin antitrypsin deficiency. 19.05.1999

Treatment of patients with pancreatic cancer that Trastuzumab Herceptin overexpress p185HER2. 14.12.1999

Treosulfan Ovastat Treatment of ovarian cancer. 16.05.1994

Tretinoin ATRA-IV Treatment of acute and chronic leukemia. 14.01.1993

Tretinoin ATRA-IV Treatment of T-cell non-Hodgkin's lymphoma 11.04.2003 surface epithelia (conjunctiva and/or cornea) with Tretinoin mucous deficiency and keratinization. 15.04.1985 tri-antennary glycotripeptide derivative of 5-fluorodeoxyuridine Treatment for hepatocellular carcinoma 23.11.2001 triciribine Treatment of multiple myeloma 01.02.2008 Treatment of glycogen storage disorder II (Pompe Triheptanoin Triheptanoin-SASOL Spdisease) 01.02.2008

Triheptanoin Triheptanoim-SASOl SpTreatment of fatty acid disorders 26.05.2006

Trimetrexate Neutrexin Treatment of metastatic osteogenic sarcoma. 10.08.2000 Treatment of patients with advanced non-small cell Trimetrexate glucuronate carcinoma of the lung. 13.01.1988

Trimetrexate glucuronate Treatment of pancreatic adenocarcinoma. 25.07.1985

Trimetrexate glucuronate Treatment of metastatic colorectal adenocarcinoma. 25.07.1985

Treatment of metastatic carcinoma of the head and Trimetrexate glucuronate neck (i.e. buccal cavity, pharynx, and larynx). 25.07.1985

For use in the palliative treatment of advanced ovarian Triptorelin pamoate Decapeptyl Injection Treatmentcarcinoma of moderateepithelial origin.to severe clinical forms of 10.08.1990 hemolytic disease of the newborn arising from placental transfer of antibodies against blood group substances A Trisaccharides A and B Biosynject and B. 12.04.1987

Prevention of ABO medical hemolytic reactions arising Trisaccharides A and B Biosynject Treatmentfrom ABO-incompatible of moderate tobone very marrow severe transplantation. clinical forms of 15.04.1988 transfusion reactions arising from ABO incompatible transfusions of blood, blood products, and blood Trisaccharides A and B derivatives. 03.08.1987 For use in ABO-incompatible solid organ transplantation, including kidney, heart, liver and Trisaccharides A and B Biosynject pancreas. 20.04.1987

Trisodium citrate concentration Hemocitrate For use in leukapheresis procedures. 15.06.1995 Treatment of patients with known or suspected internal Trisodium zinc contamination with plutonium, americium, or curium to Diethylenetriaminepentaacetate increase the rate of elimination. 27.02.2004

Troxacitabine Troxatyl Treatment of acute myeloid leukemia 04.04.2005 Treatment of symptomatic patients with AIDS including Tumor necrosis factor-binding all patients with CD4 counts less than 200 cells per protein 1 mm3. 06.01.1993 Treatment of symptomatic patients with the AIDS Tumor necrosis factor-binding including all patients with CD4 T-cell counts less than protein II 200 cells per mm3. 06.01.1993

Tyloxapol Supervent Treatment of cystic fibrosis. 08.03.1995

Type 1 native bovine skin collagen Treatment of diffuse systemic sclerosis 01.02.2008 tyrosine kinase inhibitor Treatment of mastocytosis 14.09.2005

Ubiquinol Ubi-Q-Nol, Li-Q-Nol Treatment of Huntington's Disease 12.04.2004

Ubiquinol, coenzyme Q10, ubiquinone UBI-Q-NOL Treatment of pediatric congestive heart failure 12.04.2004

Ubiquinone Ubi-Q-Gel Treatment of mitochondrial cytopathies. 14.12.1999

Unconjugated Chimeric (human- murine) G250 IgG monoclonal antibody Treatment of renal cell carcinoma. 22.03.2001

Urea for intravitreal injection Neurosolve Treatment of retinitis pigmentosa 14.12.2005 To facilitate the removal of lung secretions in the Uridine 5'-triphosphate treatment of patients with primary ciliary dyskinesia. 26.06.1996

Uridine 5'-triphosphate ForTreatment the initiation of cystic and fibrosis. re-initiation of spermatogenesis in 04.12.1995 adult males with reproductive failure due to hypothalamic or pituitary dysfunction, hypogonadotropic Urofollitropin Fertinex hypogonadism. 05.12.1997 For acceleration of corneal epithelial regeneration and healing of stromal incisions from corneal transplant Urogastrone surgery. 01.11.1984 ursodiol Ursofalk Suspension Treatment of cystic fibrosis liver disease 23.10.2007

Management of the clinical signs and symptoms Ursodiol Actigall associated with primary biliary cirrhosis. 19.02.1991

Valine, isoleucine and leucine VIL Treatment of hyperphenylalaninemia 05.01.1996

Treatment of primary keratoconjunctivitis and recurrent valine-valine-ganciclovir epithelial keratitis due to HSV1 and HSV2. 21.05.2007

Valproate Treatment of fragile X syndrome 05.05.2008

Valproic acid, sodium PEAC Treatment of familialpatients adenomatous with follicular polyposisthyroid carcinoma, 24.06.2005 medullary thyroid carcinoma, anaplastic thyroid carcinoma, and locally advanced and metastatic Vandetanib Zactima papillary thyroid carcinoma 21.10.2005

Vapreotide Sanvar Treatment of symptomatic carcinoid tumors 06.04.2004

Treatment of esophageal variceal hemorrhage patients vapreotide Sanvar with portal hypertension. 10.01.2000 vapreotide Octastatin Treatment of gastrointestinal and pancreatic fistulas. 10.01.2000

Prevention of early postoperative complications vapreotide Octastatin following pancreatic resection. 06.03.2000 vapreotide Sanvar Treatment of acromegaly 04.11.2003

Prevention of acute chest syndrome in at-risk patients varespladib sodium with sickle cell disease 19.11.2007 Passive immunization for the treatment of exposed, Varicella Zoster Immune Globulin susceptible individuals who are at risk of complications (Human) VariZIG from varicella 07.11.2006 vascular endothelial growth factor Treatment of advanced melanoma stages IIb through 165b IV. 24.06.2008 Vasoactive intestinal peptide Treatment of Acute Respiratory Distress Syndrome. 09.03.2001

Vasoactive intestinal polypeptide Treatment of acute esophageal food impaction. 23.06.1993 veltuzumab Treatment of chronic lymphocytic leukemia 28.08.2008

Debridement of severe, deep dermal burns in Vibriolysin Vibrilase hospitalized patients 16.06.2006 vigabatrin Sabril Treatment of infantile spasms. 12.06.2000

Viloxazine HCl Catatrol Treatment of narcolepsy. 11.06.1984

Viloxazine HCl Catatrol Treatment of cataplexy. 11.06.1984 vincristine sulfate liposome injection Marqibo Treatment of acute lymphoblastic leukemia. 08.01.2007 vincristine sulfate liposomes Marqibo (r) Treatment of metastatic uveal melanoma. 24.06.2008

Virulizin Virulizin Treatment of pancreatic cancer. 01.02.2001 viscous budesonide Treatment for pediatric eosinophilic esophagitis. 20.12.2006 vistonuridine An antidote in the treatment of 5-fluorouracil poisoning. 01.05.2009 vorinostat Treatment of multiple myeloma 12.06.2003 vorinostat Treatment of mesothelioma 17.03.2004 Treatment of telomerase reverse transcriptase (TERT) positive non-small cell lung cancer in HLA-A*0201 Vx-001 positive patients 20.02.2009 Xenogeneic hepatocytes HepatAssist Liver AssisTreatment of severe liver failure. 27.11.1998

Yttrium (90Y) antiferritin polyclonal antibodies Ferritarg P Treatment of Hodgkin's disease. 18.09.2006 Yttrium-90 radiolabeled humanized monoclonal anti- carcinoembroyonic antigen IgG Cea-Cide Treatment of ovarian carcinoma. 03.08.1999

Zalcitabine Treatment of AIDS. 09.12.1986

Zosuquidar trihydrochloride Treatment of acute myeloid leukemia 15.12.2005 Sponsor Address

104 Chancellor Matheson Winnipeg, ManitobaR3T Cangene Corporation Road 5Y3 CANADA

Philadelphia PA 19101- Wyeth Pharmaceuticals, Inc. P. O. Box 8299 8299

Fleming & Company, Pharmaceuticals 1733 Gilsinn Lane Fenton MO 63026

2751 Napa Valley Dey Laboratories Corporate Drive Napa CA 94558

EMD Serono, Inc. One Technology Place Rockland MA 02370

South San Francisco CA Genentech, Inc. 1 DNA Way 94080-4990 Princeton NJ Novo Nordisk Pharmaceuticals 100 Overlook Center Suite 200 08540

ONY, Inc. 1576 Sweet Home Road Amherst NY 14228

Dutch Ophthalmic Research P.O. Box 43 3214ZG Center Int'l BV Scheijdelveweg 2 Zuidland NETHERLANDS

GTC Biotherapeutics, Inc. 175 Crossing Blvd Framingham MA 01702 King of Prussia PA CSL Behring, LLC 1020 First Avenue P.O. Box 61501 19406

Antisoma 300 Technology Square Cambridge MA 02139

Genzyme Corporation 500 Kendall Street Cambridge MA 02142 1250 South Collegeville Collegeville GlaxoSmithKline Road UP 4110 PA 19426 Eisai Medical Research, Inc. 55 Challenger Road Ridgefield NJ 07660

ViroPharma Incorporated 730 Stockton Drive Exton PA 19341

GE Healthcare, Inc. 101 Carnegie Center Princeton NJ 08540

GE Healthcare, Inc. 101 Carnegie Center Princeton NJ 08540

Talecris 8368 US 70 West Clayton NC 27520

Thousand Oaks CA 91320- Amgen, Inc. One Amgen Center Drive 1799

Washington Prestwick Pharmaceuticals, Inc 1825 K Street NW Suite 1475 DC 20006

Bayer Pharmaceuticals Corporation 400 Morgan Lane West Haven CT 06516

Cephalon, Inc. 41 Moores Road Frazer PA 19355

Spectrum Pharmaceuticals, Inc. 157 Technology Drive Irvine CA 92618

Regeneron Pharmaceuticals, 777 Old Saw Mill River Inc. Road Tarrytown NY 10591

Abbott Laboratories 200 Abbott Park Road Abbott Park IL 60064-6157 Cambridge MA 02139- Genzyme Corporation One Kendall Square 1562

Biomarin Pharmaceutical Inc. 371 Bel Marin Blvd. Novato CA 94949

Novartis Pharmaceutical East Hanover NJ 07936- Corporation One Health Plaza 1080

Indianapolis Eli Lilly and Company Lilly Corporate Center Drop Code 1853 IN 46285

Topo Target A/S Fruebjergvej 3, 2100 Copenhagen DENMARK

IPSEN, Inc. 27 Maple Street Milford MA 01757 Westminister CO 80021- Gilead Colorado 7575 West 103rd Avenue Suite 102 5426

Novo Nordisk Inc. 100 College Road West Princeton NJ 08540

Phildelphia PA 19101- Wyeth Pharmaceuticals, Inc. P. O. Box 8299 8299 Johnson & Johnson Pharmaceutical Research & 920 US Highway 202, P. Dev. O. Box 300 Raritan NJ 08869

Indevus Pharmaceuticals (Formerly Valera Pharma.) 33 Hayden Avenue Lexington MA 02421

Cangene Corporation 155 Innovation Drive CANADA

West Lake Village CA Baxter Healthcare Corporation One Baxter Way 91362

Alexion Pharmaceuticals, Inc. 352 Knotter Drive Cheshire CT 06410 Los Angeles CA 90032- Grifols Biologicals Inc. 5555 Valley Boulevard 3548

1700 Perimeter Park Salix Pharmaceuticals, Inc. Drive Morrisville NC 27560

Merck Sante, s.a.a. 37 rue Saint Romain 69008 Lyon FRANCE

Novartis Pharmaceuticals East Hanover NJ 07936- Corporation One Health Plaza 1080

Novartis Pharmaceuticals East Hanover NJ 07936- Corporation One Health Plaza 1080

Novartis Pharmaceuticals East Hanover NJ 07936- Corporation One Health Plaza 1080 Novartis Pharmaceuticals East Hanover NJ 07936- Corporation One Health Plaza 1080

Novartis Pharmaceuticals East Hanover NJ 07936- Corporation One Health Plaza 1080

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

P. O. Box 2000, RY 32- Merck & Co., Inc. 605 Rahway NJ 07065-0900

Dialysis Solutions, Inc. 14 Emmett Place Whitby, Ontario L1R 2B4 CANADA

Shire Human Genetic Therapies, Inc. 700 Main Street Cambridge MA 02139

Celgene Corporation 86 Morris Avenue Summit NJ 07901 Bristol-Myers Squibb Company 5 Research Parkway Wallingford CT 06492

Bristol-Myers Squibb Company 5 Research Parkway Wallingford CT 06492

Celgene Corporation 7 Powder Horn Dr. Warren NJ 07059

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355-1307

Baltimore MD Eisai Medical Research, Inc. 6611 Tributary Street Suite 200 21224

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

Westport CT Farmacon-IL, LLC 1720 Post Road East Suite 213 06880-5643

Astellas Pharma US, Inc. Three Parkway North Deerfield IL 60015-2548

ImClone Systems Incorporated 33 ImClone Drive Branchburg NJ 08876

Celgene Corporation 86 Morris Avenue Summit NJ 07901

Bayer Pharmaceutical Corporation 400 Morgan Lane West Haven CT 06516

8720 Stony Point Richmond VA Insmed, Inc. Parkway Suite 200 23235

Jazz Pharmaceuticals 3180 Porter Drive Palo Alto CA 94304

Novartis Pharmaceuticals East Hanover NJ 07936- Corporation 59 Route 10 1080

GlaxoSmithKline One Franklin Plaza Phildelphia PA 19101 2000 Sierra Point Brisbane CA Tercica, Inc. Parkway Suite 400 94005

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

AR Holding Company, Inc. 1100 Orthodox Street Philadelphia PA 19124

Boehringer Ingelheim Ridgefield CT Pharmaceuticals, Inc. 900 Ridgebury Road P. O. Box 368 06877-0368

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

BioMarin Pharmaceutical, Inc. 105 Digital Drive Novato CA 94949-5608

Bausch & Lomb 8500 Hidden River Pharmaceuticals, Inc. Parkway Tampa FL 33637

Millennium Pharmaceuticals, Inc. 40 Landsdowne Street Canbridge MA 02139 Schering-Plough Reasearch Institute 2000 Galloping Hill Rd. Kenilworth NJ 07033

64 Thomas Johnson DynPort Vaccine Company LLC Drive Frederick MD 21702

Medicis Pharmaceutical Corp. 8125 N. Hayden Road Scottsdale AZ 85258

South San Francisco CA CoTherix, Inc. 5000 Shoreline Court 94080 San Antonio TX 78229- Genzyme Corporation 4545 Horizon Hill Blvd. 2263

EMD Serono, Inc. One Technology Place Rockland MA 02370

Paramus NJ Mayne Pharma (USA) Inc. Mack-Cali Centre II Second Floor 07652 Hameln Pharmaceuticals gmbh Langes Feld 13 Hameln GERMANY

Nutritional Restart 4364 South Alston Pharmaceutical, L.P. Avenue Durham NC 27713 Overland Park KS Celgene Corporation 9900 W. 109th Street Suite 300 66210

Presutti Laboratories, Inc. 1607 N. Douglas Ave. Arlington Heights IL 60004

Presutti Laboratories, Inc. 1607 N. Douglas Avenue Arlington Heights IL 60004

Ipsen Limited 190 Bath Road Slough, Berkshire SL1 3XE UNITED KINGDOM Thousand Oaks CA Amgen, Inc. One Amgen Center Drive 91320-1799

Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285

Cumberland Pharmaceuticals, Nashville TN Inc. 209 10th Street South Suite 332 37203

EMD Serono, Inc. One Technology Place Roackland MA 02370

California Department of Health Services 2151 Berkeley Way Berkeley CA 94704-1011

Heyl Chemisch-Pharmzeutische D-14167 Berlin, Federal Fabrik GMBH & Co, KG Goerzallee 253 Republic of Germany GERMANY

Birmingham Axcan Scandipharm Inc. 22 Inverness Parkway Suite 310 AL 35242

Actelion Pharmaceuticals Ltd Gewerbestrasse 16 CH - 4123 Allschwi SWITZERLAND Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033 King of Prussia PA GlaxoSmithKline 2301 Renaissance Blv. P.O. Box 61540 19406-2772

Millennium Pharmaceuticals, Inc. 40 Landsdowne Street Cambridge MA 02139

371 Bel Marin Keys BioMarin Pharmaceutical, Inc. Boulevard, Suite 210 Novato CA 94949-5608

Cambridge MA 02139- Genzyme Corporation One Kendall Square 1562

Austin TX Sensus Corporation Suite 430, 98 San Jacinto Boulevard 78701

Guilford Pharmaceuticals, Inc. 6611 Tributary Street Baltimore MD 21224

McGaw Park Baxter Healthcare Corporation Renal Division 1620 Waukegan Road IL 60085

6200 Courtney Campbell Tampa FL Romark Laboratories, L.C. Causeway Suite 880 33607

6200 Courtney Campbell Tampa FL Romark Laboratories, L.C. Causeway Suite 880 33607

Silver Spring MD 20905- ChiRhoClin, Inc. 15500 Gallaudet Ave. 4176 Reckitt Benckiser Pharmaceuticals, Inc. 1901 Huguenot Road Richmond VA 23235

Reckitt Benckiser Pharmaceuticals, Inc. 1901 Huguenot Road Richmond VA 23235

Jazz Pharmaceuticals 3180 Porter Drive Palo Alto CA 94304

Sanofi-Synthelabo Research 9 Great Valley Parkway Malvern PA 19355 Research Triangle Park United Therapeutics Corp. 68 T.W. Alexander Dr. P.O. Box 14186 NC 27709

Silver Spring MD 20905- ChiRhoClin, Inc. 15500 Gallaudet Ave. 4176

Silver Spring MD 20905- ChiRhoClin, Inc. 15500 Gallaudet Ave. 4176

Seattle WA Cell Therapeutics, Inc. 501 Elliott Ave. W. Suite 400 98119

East Hanover NJ 07936- Novartis Pharmaceuticals Corp. One Health Plaza 1080

Swedish Orphan AB Drottninggatan 98 SE-111 60 Stockholm SWEDEN

San Mateo Actelion Life Sciences Ltd. 1840 Gateway Dr. 2nd Floor CA 94404 Johnson & Johnson Pharmaceutical R & D, LLC Route 202, P.O. Box 300 Raritan NJ 08869-0602

East Hanover NJ 07936- Novartis Pharmaceuticals Corp. 59 Route 10 1080

Pharmacia and Upjohn Company 7000 Portage Road Kalamazoo MI 49001

Novartis Pharmaceuticals East Hanover NJ 07936- Corporation 59 Route 10 1080

San Antonio TX 78229- Genzyme Corporation 4545 Horizon Hill Blvd. 2263

Irvine CA Allergan, Inc. 2525 Dupont Drive P.O. Box 19534 92623-9534

Malvern PA Solstice Neurosciences, Inc. 40 General Warren Blvd Suite 160 19355 Jazz Pharmaceuticals 3180 Porter Drive Palo Alto CA 94304

Serono, Inc. One Technoloogy Place Rockland MA 02370

Serono, Inc. One Technology Place Rockland MA 02370

1207 17th Ave. S., Suite Protherics, Inc. 103 Nashville TN 37212

Frazer PA Cephalon 41 Moores Road PO Box 4011 19355 Kalamazoo MI 49001- Pharmacia & Upjohn 7000 Portage Rd. 0633-298-113 0199

EMD Serono, Inc. One Technology Place Rockland MA 02370

Philadelphia PA 19101- Wyeth-Ayerst Laboratories PO Box 8299 8299 Research Triangle Park NC 27709- GlaxoSmithKline Five Moore Dr. PO Box 13398 3398 Burlingame CA 94010- InterMune , Inc. 1710 Gilbreth Road, Suite 301 1317

Eisai Medical Research, Inc. 55 Challenger Road Ridgefield Park NJ 07660

INO Therapeutics, Inc. 54 Old Highway 22 Clinton NJ 08809

Sigma-Tau Pharmaceuticals, Gaithersburg Inc. 9841 Washingtonian Blvd Suite 500 MD 20878

Kalamazoo MI 49001- Pharmacia & Upjohn 7000 Portage Road Mail Stop: 0636-298-113 0199 O.P.R. Development, L.P. 1501 Wakarusa Drive Lawrence KS 66047 Kalamazoo MI 49001- Pharmacia & Upjohn Company 0634-298-113 7000 Portage Rd. 0199

Schering-Plough Research Institute 2000 Galloping Hill Rd. Kenilworth NJ 07033 Mountain View CA Alza Corporation 1550 Plymouth St. PO Box 7210 94039-7210

Conshohocke Medimmune Oncology, Inc. One Tower Bridge 100 Front Street, Suite 400 n PA 19428

Immunex Corporation 51 University St. Seattle WA 98101-2936 King Of Prussia PA Aventis Behring L.L.C. 1020 First Avenue PO Box 61501 19406-0901

10450 Science Center Pacira Pharmaceuticals, Inc. Drive San Diego CA 92121 Princeton NJ Novo Nordisk, Inc. 100 Overlook Center Suite 200 08540-7810

Teikoku Pharma USA, Inc. 745-D Camden Ave. Campbell CA 95008-4146

Eisai Medical Research, Inc. 55 Challenger Road Ridgefield Park NJ 07660

Otsuka Pharmaceutical Company Tokyo JAPAN

Eisai Medical Research, Inc 55 Challenger Road Ridgefield Park NJ 07660 Research Glaxo Wellcome Research and Triangle Park Development 5 Moore Drive PO Box 13398 NC 27709

Cephalon, Inc. 145 Brandywine Parkway West Chester PA 19380 Massachussetts Public Health Biologic Laboratories 305 South Street Boston MA 02130-3597

Genzyme Corporation One Kendall Square Cambridge MA 02139

Novartis Pharmaceuticals East Hanover NJ 07936- Corporation 59 Route 10 1080

Novartis Pharmaceuticals East Hanover NJ 07936- Corporation 59 Route 10 1080 Novartis Pharmaceuticals East Hanover NJ 07936- Corporation 59 Route 10 1080 103 Carnegie Center, Anthra Pharmaceuticals, Inc. Suite 102 Princeton NJ 08540

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355-1307Research Glaxo Wellcome Research and Triangle Park Development 5 Moore Drive P.O. Box 13398 NC 27709

Celgene Corporation 86 Morris Avenue Summit NJ 07901 Kansas City MO 64134- Hoechst Marion Roussel P.O. Box 9627 Mail Station: H3-M2516 0627

Morgantown WV 26504- Mylan Laboratories, Inc. 781 Chestnut Ridge Road P.O. Box 4310 4310

Novartis Pharmaceuticals East Hanover NJ 07936- Corporation 59 Route 10 1080

QOL Medical, LLC 12419 198th Drive, NE Woodinville WA 98072 Thousand Oaks CA 91320- Amgen, Inc. One Amgen Center Dr. 1799

Hoechst Marion Roussel Frankfurt am Main P.O. Box 1140 Marburg GERMANY Bristol-Myers Squibb Pharmaceutical Research Institute P.O. Box 4000 Princeton NJ 08543 Bloomington 5775 West Old Shakopee MN 55437- MGI Pharma, Inc. Rd. Suite 100 3107

Chiron Corporation 4560 Horton Street Emeryville CA 94608-2916

Bryan Corporation 4 Plympton Street Woburn MA 01801 East Hanover NJ 07936- Novartis Pharmaceuticals Corp Drug Regulatory Affairs One Health Plaza 1080

460 Point San Bruno South San Francisco CA Genentech, Inc. Boulevard 94080

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Mount St. Hilaire Quebec Axcan Pharma Inc. 597 Laurier Blvd H7L 4S3

Jazz Pharmaceuticals 3180 Porter Drive Palo Alto CA 94304

South San Francisco CA Genentech, Inc. 1 DNA Way, MS 242 94080-4990

Genetics Institute, Inc. 87 Cambridge Park Drive Cambridge MA 02140

Kalamazoo MI 49001- Pharmacia & Upjohn 7000 Portage Road 0199

EMD Serono, Inc. One Technology Place Rockland MA 02370 Fujisawa USA, Inc. 3 Parkway North Center Deerfield IL 60015

Fujisawa USA, Inc. 3 Parkway North Center Deerfield IL 60015 Bristol-Myers Squibb Wallingford Pharmaceutical Research CT 06492- Institute 5 Research Parkway P.O. Box 5100 7660

Valeant Pharmaceuticals 3300 Hyland Avenue Costa Mesa CA 92626

Orion Corporation P.O. Box 65 02101 ESPOO FINLAND

Eatontown NJ Roberts Pharmaceutical Corp. Meridian Center III 6 Industrial Way West 07724

Genetics Institute, Inc. 87 Cambridge Park Drive Cambridge MA 02140

Lemmon Company 1510 Delp Drive Kulpsville PA 19443

Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285 460 Point San Bruno South San Francisco CA Genentech, Inc. Boulevard 94080

Teva Pharmaceuticals USA 1510 Delp Drive Kulpsville PA 19443

Serono One Technology Place Rockland MA 02370

Jazz Pharmaceuticals 3180 Porter Drive Palo Alto CA 94304

Liposome Company, Inc. One Research Way Princeton NJ 08540

Roxane Laboratories, Inc. PO Box 16532 Columbus OH 43216-6532

QOL Medical, LLC 12419 198th Drive, NE Woodinville WA 98072

Palo Alto CA Alza Corporation 950 Page Mill Rd. PO Box 10950 94303-0802 Guilford Pharmaceuticals, Inc. 6611 Tributary Street Baltimore MD 21224

Schier Ridgewood F.K.A. Eatontown NJ (Roberts Pharmaceutical Corp.) Meridian Center III 6 Industrial Way West 07724

EMD Serono, Inc. One Technology Place Rockland MA 02370

Warner-Lambert Company 2800 Plymouth Road Ann Arbor MI 48106

SmithKline Beecham Philadelphia Pharmaceuticals One Franklin Plaza P.O. Box 7929 PA 19101

SmithKline Beecham Philadelphia Pharmaceuticals One Franklin Plaza P.O. Box 7929 PA 19101

400 Rella Boulevard, Ferring Laboratories, Inc. Suite 201 Suffern NY 10901

Irvine CA Allergan, Inc. 2525 Dupont Drive P.O. Box 19534 92713

Catalytica Pharmaceuticals, Inc PO Box 1887 Greenville NC 27835-1887

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Medicis Pharmaceutical Corp. 8125 N. Hayden Road Scottsdale AZ 85258

NeXstar Pharmaceuticals, Inc. 650 Cliffside Drive San Dimas CA 91773

Bausch & Lomb Surgical, Chiron Vision Products 9342 Jeronimo Road Irvine CA 92718-1903 Bristol-Myers Squibb Pharmaceutical Research Institute P.O. Box 4000 Princeton NJ 08543 MedImmune & Massachussetts 35 West Watkins Mill Public Health Biologics Labs. Road Gaithersburg MD 20878

Amgen, Inc. 1840 Dehavilland Drive Thousand Oaks CA 91320

401 North Middletown Pearl River QLT Phototherapeutics, Inc. Lederle Laboratories Road NY 10965

Rhone-Poulenc Rorer 500 Arcola Road, P.O. Pharmaceuticals, Inc. Box 1200 Collegeville PA 19426 West Conshohocke Medimmune Oncology, Inc. One Tower Bridge 100 Front Street, Suite 400 n PA 19428

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Research Triangle Park NC Glaxo Wellcome Inc. 5 Moore Drive 27709

Immunex Corporation 51 University Street Seattle WA 98101

Wyeth-Ayerst Laboratories P.O. Box 8299 Philadelphia PA 19101

Kalamazoo MI 49001- Pharmacia & Upjohn 7000 Portage Road 0199

104 Chancellor Matheson Rh Pharmaceuticals, Inc. Road Winnipeg, Manitoba CANADA

Amgen, Inc. 1840 Dehavilland Drive Thousand Oaks CA 91320

Morgantown Mylan Laboratories, Inc. 781 Chestnut Ridge Road P.O. Box 4310 WV 26504 227-15 North Conduit Eon Labs Manufacturing, Inc. Avenue Laurelton NY 11413 Jacobus Pharmaceutical Princeton NJ Company 37 Cleveland Lane P.O. Box 5290 08540

Amgen, Inc. 1840 Dehavilland Drive Thousand Oaks CA 91320

Hoechst Marion Roussel P.O. Box 9627 Kansas City MO 64134

Cambridge MA 02139- Genzyme Corporation One Kendall Square 1562 Bloomington 5775 West Old Shakopee MN 55437- MGI Pharma, Inc. Rd. Suite 100 3107 King of Prussia PA Aventis Behring L.L.C. 1020 First Avenue PO Box 61501 19406-0901

Enzon, Inc. 20 Kingsbridge Road Piscataway NJ 08854

460 Point San Bruno South San Francisco CA Genentech, Inc. Boulevard 94080

West Haven Bayer Corporation Pharmaceutical Division 400 Morgan Lane CT 06516

Pharmaceutical Division, New Haven Bayer Corporation Biological Products 400 Morgan Lane CT 06516 West Conshohocke Medimmune Oncology, Inc. One Tower Bridge 100 Front Street, Suite 400 n PA 19428

460 Point San Bruno South San Francisco CA Genentech, Inc. Boulevard 94080

Bristol-MyersAlcon Laboratories, Squibb Inc. 6201 South Freeway Fort Worth TX 76134 Pharmaceutical Research 2400 West Lloyd Institute Expressway Evansville IN 47721

Wallace Laboratories 301B College Road East Princeton NJ 08540 Chiron Corp. & Berlex Laboratories 4560 Horton Street Emeryville CA 94608

8180 Greensboro Drive, Biodevelopment Corporation Suite 1000 McLean VA 22102

Tap Pharmaceuticals, Inc. 2355 Waukegan Road Deerfield IL 60015

R. W. Johnson Pharmaceutical Research Institute Route 202, P.O. Box 300 Raritan NJ 08869

Bayer Corporation 1884 Miles Avenue Elkhart IN 46515

Cytogen Corporation 600 College Road East Princeton NJ 08540

Adria Laboratories, Inc. P.O. Box 16529 Columbus OH 43216

Unimed Pharmaceuticals, Inc. 901 Sawyer Rd. Marietta GA 30062

Sigma-Tau Pharmaceuticals, 9841 Washingtonian Gaithersburg Inc. Blvd. Suite 500 MD 20878

Research Triangle Park NC Glaxo Wellcome Inc. 5 Moore Drive 27709

Research Triangle Park NC Glaxo Wellcome Inc. 5 Moore Drive 27709

Berlex Laboratories, Inc. 300 Fairfield Road Wayne NJ 07470

Armour Pharmaceutical 500 Arcola Road, P.O. Company Box 1200 Collegeville PA 19426

SmithKline Beecham Philadelphia Pharmaceuticals One Franklin Plaza P.O. Box 7929 PA 19101 Bristol-Myers Squibb Pharmaceutical Research Wallingford Institute 5 Research Parkway P.O. Box 5100 CT 06492

Medtronic, Inc. 800 53rd Avenue N.E. Minneapolis MN 55432

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Chiron Corporation 4560 Horton Street Emeryville CA 94608-2916

Syntex (USA), Inc. 3401 Hillview Avenue Palo Alto CA 94303

SmithKline Beecham Philadelphia Pharmaceuticals One Franklin Plaza P.O. Box 7929 PA 19101

Pharmaceutical Division, New Haven Bayer Corporation Biological Products 400 Morgan Lane CT 06516 Eatontown NJ Roberts Pharmaceutical Corp. Meridian Center III 6 Industrial Way West 07724

Immunex Corporation 51 University Street Seattle WA 98101 Dublin CA SuperGen, Inc. 4140 Dublin Blvd. Suite 200 94568

Elkins-Sinn, Inc. 2 Esterbrook Lane Cherry Hill NJ 08003

Ross Laboratories 625 Cleveland Avenue Columbus OH 43215

Ross Laboratories 625 Cleveland Avenue Columbus OH 43215 15049 San Pablo Avenue, Berlex Laboratories, Inc. P.O. Box 4099 Richmond CA 94804

Cambridge MA 02139- Genzyme Corporation One Kendall Square 1562 Immunex Corporation 51 University Street Seattle WA 98101

Solopak Pharmaceutical Co. 1845 Tonne Road Elk Grove Village IL 60007

Alpha Therapeutic Corporation 5555 Valley Boulevard Los Angeles CA 90032

Amgen, Inc. 1840 Dehavilland Drive Thousand Oaks CA 91320

Conshohocke Medimmune Oncology, Inc. One Tower Bridge 100 Front Street, Suite 400 n PA 19428

InterMune, Inc. 3280 Bayshore Blvd Brisbane CA 94005

Fresenius Medical Care North America 920 Winter Street Waltham MA 02451

Hoechst Marion Roussel P.O. Box 9627 Kansas City MO 64134

United-Guardian, Inc. P.O. Box 2500 Smithtown NY 11787

Adria Laboratories, Inc. P.O. Box 16529 Columbus OH 43216

Research Triangle Park NC Glaxo Wellcome Inc. 5 Moore Drive 27709 Research Triangle Park NC Glaxo Wellcome Inc. 5 Moore Drive 27709

1500 E. Medical Center Ann Arbor MI University of Michigan UH B1 H410/0028 Drive 48109-0028

Enzon, Inc. 20 Kingsbridge Road Piscataway NJ 08854

Irvine CA Allergan, Inc. 2525 Dupont Drive P.O. Box 19534 92713 Irvine CA Allergan, Inc. 2525 Dupont Drive P.O. Box 19534 92713

Rochester NY Fisons Corporation 755 Jefferson Rd P.O. Box 1710 14603

Pharmacia & Upjohn AB Lindhagensgatan 133 SE-112 87 SWEDEN

400 Rella Boulevard, Ferring Laboratories, Inc. Suite 201 Suffern NY 10901

Syntex (USA), Inc. 3401 Hillview Avenue Palo Alto CA 94304

Fujisawa USA, Inc. 3 Parkway North Center Deerfield IL 60015

777 South Harbor Island Somerset Pharmaceuticals, Inc. Boulevard Tampa FL 33602

Amgen, Inc. 1840 Dehavilland Drive Thousand Oaks CA 91320

Hoechst Marion Roussel P.O. Box 9627 Kansas City MO 64134

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110 Bristol-Myers Squibb Pharmaceutical Research 5 Research Parkway, Institute P.O. Box 5100 Wallingford CT 06492

Degussa Corporation 65 Challenger Road Ridgefield Park NJ 07660

Block Drug Company, Inc. 257 Cornelison Avenue Jersey City NJ 07302 Saint Louis MO 63141- Bock Pharmacal Company P.O. Box 419056 9056

Galderma Laboratories, Inc. P.O. Box 331329 Fort Worth TX 76163

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Immunex CorporationThe 51 University University Street of Texas Seattle WA 98101 Health Scienc Center at 5323 Harry Hines Dallas TX Pak, Charles Y.C. M.D. Da Boulevard 75235

Division of American Pearl River Lederle Laboratories Cyanamid Company 401 N. Middletown Road NY 10965 Immunex Irvine CA Immunex 2525 McGaw Avenue P.O. Box 19791 92623

Division of American Pearl River Lederle Laboratories Cyanamid Company 401 N. Middletown Road NY 10965 Rhone-Poulenc Rorer Pharmaceuticals, Inc. 500 Arcola Road Collegeville PA 19426

Pharmaceutical Division, New Haven Bayer Corporation Biological Products 400 Morgan Lane CT 06516 E.I. Du Pont De Nemours Du Pont Pharmaceuticals & Co. Wilmington DE 19898 Bloomington 5775 West Old Shakoppe MN 55437- MGI Pharma, Inc. Rd. Suite 100 3107

Research Triangle Park NC Glaxo Wellcome Inc. 5 Moore Drive 27709

Research Triangle Park NC Glaxo Wellcome Inc. 5 Moore Drive 27709 Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285

Pharmacia Inc. P.O. Box 16529 Columbus OH 43216

Novartis Pharmaceutical Corporation 59 Route 10 East Hanover NJ 07936

Novartis Pharmaceutical Corporation 59 Route 10 East Hanover NJ 07936

EMD Serono, Inc. One Technology Place Rockland MA 02370

Research Triangle Park NC Glaxo Wellcome Inc. 5 Moore Drive 27709

Sigma-Tau Pharmaceuticals, Gaithersburg Inc. 9841 Washingtonian Blvd Suite 500 MD 20878

Merck Sharp & Dohme Division Of Merck And Research Company West Point PA 19486

7855 Gross Point Road, Ethitek Pharmaceuticals, Inc. Unit L Skokie IL 60077 460 Point San Bruno South San Francisco CA Genentech, Inc. Boulevard 94080

460 Point San Bruno South San Francisco CA Genentech, Inc. Boulevard 94080 University of Texas Health Science Center at Dallas 5323 Harry Hines Blvd Dallas TX 75235

University of Texas Health Science Center at Dallas 5323 Harry Hines Blvd Dallas TX 75235

University of Texas Health 5323 Harry Hines Science Center at Dallas Boulevard Dallas TX 75235

E.I. Du Pont De Nemours DuPont Pharmaceuticals & Co. Wilmington DE 19880 Fujisawa USA, Inc. 3 Parkway North Center Deerfield IL 60015

Rochester NY Fisons Corporation 755 Jefferson Rd. P.O. Box 1710 14603

Solvay 901 Sawyer Road Marietta GA 30062

Abbott Laboratories Diagnostics Division Abbott Park IL 60064

Intarcia Therapeutics, Inc. 24650 Industrial Blvd Hayward CA 94545

Marshall Edwards, Inc. 140 Wicks Road AUSTRALIA

Marshal Edwards, Inc. 140 Wicks Road AUSTRALIA

Marshall Edwards, Inc. 140 Wicks Road AUSTRALIA

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

Tibotec, Inc. 1020 Stony Hill Road Yardley PA 19067

BioCryst Pharmaceuticals, Inc. 2190 Parkway Lake Drive Birmingham AL 35244

BioCryst Pharmaceuticals, Inc. 2190 Parkway Lake Drive Birmingham AL 35244

BioCryst Pharmaceuticals, Inc. 2190 Parkway Lake Drive Birmingham AL 35244

Fujisawa Healthcare, Inc. Three Parkway North Deerfield IL 60015-2548

Global Alliance for TB Drug Development 80 Broad Street New York NY 10004 Pfizer Global Research and Development 50 Pequot Avenue New London CT 06320

Gaithersburg Sigma-Tau Research, Inc. 9841 Washingtonian Blvd Suite 502 MD 20878

San Diego Adventrx Pharmaceuticals, Inc. 6725 Mesa Ridge Road Suite 100 CA 92121 Inotek Pharmaceuticals Corporation 100 Cummings Center Beverly MA 01915

Otsuka Pharmaceutical Company, Ltd 2440 Research Blvd Rockville MD 20850 Abbott Park IL 60064- Abbott Laboratories 200 Abbott Park Road AP34/RA72 6188

Abbott Laboratories 200 Abbott Park Road Abbott Park IL 60064

Abbott Park IL 60064- Abbott Laboratories 200 Abbaott Park Road AP34/RA72 6188

3130 Highland Avenue, Phase 2 Discovery, Inc. Third Floor Cincinnati OH 45219-2374

Cincinnati OH Phase 2 Discovery, Inc. 3130 Highland Ave. Third Floor 45219

Ferrokin BioSciences, Inc. 2729 Debbie Court San Carlos CA 94070

Auris Medical, Inc. 211 East Ontario Street Chicago IL 60611

Winston Laboratories, Inc. 100 Fairway Drive Vernon Hills IL 60061

Molecular Insight Pharmaceuticals, Inc. 160 Second Street Cambridge MA 02142 Research PO Box 14287; 79 T.W. Triangle Park Aeolus Pharmaceuticals, Inc. Alexander Dr. 4401 Research NC 27709

BioSynthema, Inc. 4041 Forest Park Avenue St. Louis MO 63108

Clinuvel Inc. 353 Sacramento Street San Francisco CA 94111

United Oxford GlycoSciences 10, The Quadrant Abington Science Park Kingdom UNITED KINGDOM

S*BIO Pte., Ltd. 1 Science Park Road Singapore Science Park II SINGAPORE Louisiana State University New Orleans Medical Center Foundation 1600 Canal St. 10th Floor LA 70112

NeoRx Corporation 410 W. Harrison Street Seattle WA 98119-4007

Hologic, Inc. 1240 Elko Drive Sunnyvale CA 94089 Wallingford CT 06492- Bristol-Myers Squibb Company Research & Development 5 Research Parkway 7660

Amicus Therapeutics, Inc. 6 Cedar Brook Drive Cranbury NJ 08512

Amicus Therapeutics, Inc 6 Cedar Brook Drive Cranbury NJ 08512

HemaQuest Pharmaceuticals, Inc. 101 Federal Street Boston MA 02110

9640 Medical Center EntreMed, Inc. Drive Rockville MD 20850

Research Triangle Park Durham NC EntreMed, Inc. Center Suite 400 27703

FoldRx Pharmaceuticals, Inc. 300 Technology Square Cambridge MA 02139 Somerset NJ Callisto Pharmaceuticals, Inc. 2 Executive Drive Suite 450 08873

Callisto Pharmaceuticals, Inc. 420 Lexington Avenue New York NY 10170

Waltham MA Repligen Corporation 41 Seyon Street Building 1, Suite 100 02453

Knopp Neurosciences, Inc. 2100 Wharton Street Pittsburgh PA 15203

BioQuant, Inc. 6330 Nancy Ridge Drive San Diego CA 92121 Global Pharmaceutical Abbott Park Research and IL 60064- Abbott Laboratories Development 200 Abbott Park Road 6157

Global Pharmaceutical Research and Abbott Laboratories Development Abbott Park IL 60064

Inologic, Inc. 101 Elliott Ave., West Seattle WA 98119

University of Utah Health 50 North Medical Drive, Salt Lake City Kennedy & Hoidal, M.D.'s Sciences Center Room 4R240 UT 84132

Rexahn Corporation 9620 Medical center Drive Rockville MD 20850

9620 Medical Center Rexahn Corporation Drive Rockville MD 20850

Rexahn Corporation 9620 Medical center Drive Rockville MD 20850 9620 Medical Center Rexahn Corporation Drive Rockville MD 20850

9620 Medical Center Rexahn Corporation Drive Rockville MD 20850 NIH, Exec. Plaza N., National Cancer Institute, Dct Room 7-18 Bethesda MD 20892

Lemmon Company 1510 Delp Drive Kulpsville PA 19443 Montreal, Professor of Medicine, Quebec H3T Lawrence Panasci, MD McGill University 3755 Cote Ste Catherine 1E2 CANADA

Pangene Corporation 5500 Stewart Avenue Fremont CA 94538

Massey Cancer Center, Richmond VA Grant, Steven M.D. VCU P.O. Box 980230 23298-0230

Neurophyxia B.V. Onderwijsboulevard 219 NETHERLANDS

PR Pharmaceuticals, Inc. 1716 Heath Parkway Fort Collins CO 80524 9640 Medical Center EntreMed, Inc. Drive Rockville MD 20850

9640 Medical Center EntreMed, Inc. Drive Rockville MD 20850

9640 Medical Center EntreMed, Inc. Drive Rockville MD 20850

Prosena B.V. Einsteinweg 55 NETHERLANDS

South San Francisco CA Sugen, Inc. 230 East Grand Ave. 94080

South San Francisco CA Sugen, Inc. 230 East Grand Ave. 94080-4811 Jacobus Pharmaceutical Princeton NJ Company 37 Cleveland Avenue P.O. Box 5290 08540

Underhill VT Elliot Danforth, Jr., M.D. University of Vermont 84 Beartown Road 05489

PTC Therapeutics, Inc. 100 Corporate Court South Plainfield NJ 07080 PTC Therapeutics 100 Corporate Court South Plainfield NJ 07080

PTC Therapeutics, Inc. 100 Corporate Court South Plainfield NJ 07080

Berlex Laboratories, Inc. 1401 Harbor Bay Parkway Alameda CA 94501

Seaside Therapeutics 840 Memorial Drive Cambridge MA 02139

Dynogen Pharmaceuticals, Inc. 52 Second Avenue Waltham MA 02451

NeuroSearch Sweden AB Scerige Pederstrupvej 93 SWEDEN

Kiadis Pharma Canada, Inc. 2525 Marie Curie Canada H4S 2E1 CANADA

Kiadis Pharma Canada, Inc. 2525 Marie Curie CANADA

Kiadis Pharma Canada, Inc. 2525 Marie Curie Canada H4S 2E1 CANADA

Saint-Laurent (Quebec) Kiadis Pharma Canada, Inc. 2525 Marie-Curie H4S 2E1 CANADA

Thallion Pharmaceuticals, Inc. 7150 Alexander-Fleming CANADA

Conatus Pharmaceuticals, Inc. 4365 Executive Drive San Diego CA 92121

SuperGen, Inc. 4140 Dublin Blvd Dublin CA 94568

Biomedical Frontiers, Inc. 1095 10th Ave., S.E. Minneapolis MN 55414

Metabasis Therapeutics, 11119 North Torrey Pines Incorporated Road LaJolla CA 92037

Acorda Therapeutics, Inc. 15 Skyline Drive Hawthorne NY 10532 Jacobus Pharmaceutical Co., Inc. 37 Cleveland Lane Princeton NJ 08540

Burlington VT Beeken, Warren M.D. University Of Vermont Given C-317 05405 Parc scientifique de Trophos SA Lumigny, Case 931 1322 Marseille cedex FRANCE Johnson & Johnson Pharmaceutical Research & Raritan NJ Dev, 920 U S Highway 202 P.O. Box 300 08869

Corvallis OR SIGA Technologies, Inc. 4575 SW Research Way Suite 230 97333

Corvallis OR SIGA Technologies, Inc. 4575 SW Research Way Suite 230 97333

ClinTec International Ltd./Caledonia Pharma Ltd. Guerickestrasse 25 80805 Munich, GERMANY

1950 N. Stemmons Reata Pharmaceuticals, Inc. Freeway Dallas TX 75207-3199

Now Pharm AG 241, route d'Arlon L-1150 LUXEMBOURG

San Antonio TX 78229- ILEX Oncology, Inc. 4545 Horizon Hill Blvd. 2263

Humanetics, Inc. 10400 Viking Drive Eden Prairie MN 55344

Sirtris Pharmaceuticals, Inc. 200 Technology Square Cambridge MA 02139 Research Triangle Park GlaxoSmithKline Five Moore Dr. P.O. Box 13398 NC 27709-

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Dublin CA SuperGen, Inc. 4140 Dublin Blvd. Suite 200 94568 Overland Park KS Celgene Corporation 9900 W. 109th Street Suite 300 66210 New New Brunswick Brunswick NJ Xechem International, Inc. Technoloogy Center Building 1, Suite 310 South08901-3279 San Francisco CA Hana Biosciences, Inc. 7000 Shoreline Court Suite 370 94080

InterMune, Inc. 3280 Bayshore Blvd Brisbane CA 94005

Clavis Pharma ASA Parkveien 53 B NORWAY

Intercept Pharmaceuticals, Inc. 18 Desbrosses Street New York NY 10013 Cornerstone Pharmaceuticals, Inc. 25 Health Science Drive Stony Brook NY 11790

Intercept Pharmaceuticals, Inc. 18 Desbrosses Street New York NY 10013

Eisai Medical Research, Inc. 55 Challenger Road Ridgefield Park NJ 07660

Oaklands Corporate Exton PA Therakos, Inc. Center 437 Creamery Way 19341

Oaklands Corporate Exton PA Therakos, Inc. Center 437 Creamery Way 19341

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Irvine CA Allergan, Inc. 2525 Dupont Drive P.O. Box 19534 92623-9534

Dublin CA SuperGen, Inc. 4140 Dublin Blvd. Suite 200 94568 Germantown MD 20875- NovoMed Pharmaceuticals, Inc. P.O. Box 900 0900

Warren NJ Celgene Corporation 7 Powder Horn Drive 07059 Burzynski Research Institute, Inc. 9432 Old Katy Road Houston TX 77055

Center for Cellular & Molecular The Children's Hospital of Therapeutics Philadelphia Philadelphia PA 19104

La Jolla Pharmaceutical Co. 6455 Nancy Ridge Dr. San Diego CA 92121

Menarini Ricerche S.p.A. Via Tito Speri 10 Pomezia Roma ITALY

Bristol-Myers Squibb Company P.O. Box 4500 Princeton NJ 08543-4500

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

Abbott Laboratories 200 Abbott Park Road Abbott Park IL 60064-6188

Amsterdam Molecular Therapeutics BV P. O. Box 22506 NETHERLANDS

Avigen, Inc. 1301 Harbor Bay Parkway Alameda CA 94502

Avigen, Inc. 1301 Harbor Bay Parkway Alameda CA 94502

Applied Genetic Technologies Corporation 11801 Research Drive Alachua FL 32615

Applied Genetic Technologies Corporation 11801 Research Drive Alachua FL 32615

Via Guglielmo Saliceto, Fondazione Telethon 5/a ITALY

1100 Olive Way, Suite Targeted Genetics Corporation 100 Seattle WA 98101 Los Angeles Medco Research, Inc. 8455 Beverly Boulevard Suite 308 CA 90048

Advantagene, Inc. 160 Paulson Road Waban MA 02468

GenStar Therapeutics San Diego Corporation 10835 Altman Row Suite 150 CA 92121

Ark Therapeutics Ltd 6 Warren Mews London W1T6AR London UNITED KINGDOM

Pediatric Pharmaceuticals, Inc. 718 Bradford Avenue Westfield NJ 07090 a Kentucky Bioprocessing (KBP) Owensboro Alpha Gal, LLC subsidiary 3700 Airpark Drive KY 42301

TolerRX, Inc. 300 Technology Square Cambridge MA 02139

AutoImmune, Inc. 128 Spring Street Lexington MA 02173

MotoGen, Inc. 3 Pine View Road Mount Kisco NY 10549

Aldagen, Inc. 2810 Meridian Parkway Durham NC 27713

Chiron Corporation 4560 Horton Street Emeryville CA 94608-2916

Chiron Corporation 4560 Horton St. Emeryville CA 94608-2916

Chiron Corporation 4560 Horton St. Emeryville CA 94608-2916

Astellas Pharma US, Inc. Three Parkway North Deerfield IL 60015-2548

Merck & Co., Inc. 126 East Lincoln Ave. Rahway NJ 07065-0900 Division of Human Children's Hospital Cincinnati OH Richard J. Wenstrup, M.D. Genetics Research Foundation 45229-3039 Cinergen, LLC 146 Medinah Drive Blue Bell PA 19422-3212

Cinergen, LLC 146 Medinah Drive Blue Bell PA 19422-3212

Cambridge MA 02139- Genzyme Corporation One Kendall Square 1562

Atlantic Healthcare Limited Maple House Halsted, Essex CO9 4BB UNITED KINGDOM

Ligand Pharmaceuticals, Inc. 10275 Science Center Dr. San Diego CA 92121-1117

Alwyn Company, Inc. 2301 Highway 60 East Lake Crystal MN 56055

Cambridge Pervasis Therapeutics, Inc. One Kendall Square First Floor MA 02139

Bayer Healthcare 50 Division Street, Suite Montville NJ Pharmaceuticals, Inc. Post Office Box 1000 503 07045-1000

Angioblast Systems, Inc. 275 Madison Avenue New York NY 10016

Applied Immunotherapeutics, 14132 E. Firestone Santa Fe Springs CA LLC Boulevard 90670

Neurotech USA, Inc. 6 Blackstone Valley Place Lincoln RI 02865

MolMed S.p.A. Via Olgettina 58 Milan 20132 ITALY Research Triangle Park Burroughs Wellcome Company 3030 Cornwallis Road P.O. Box 12700 NC 27709 Research Triangle Park Burroughs Wellcome Company 3030 Cornwallis Road P.O. Box 12700 NC 27709 Research Triangle Pk NC Burroughs Wellcome Company 3030 Cornwallis Road 27709

Dagger Lane, Elstree, Bio Products Laboratory Hertfordshire WD6 3BX UNITED KINGDOM

Bio Products Laboratory Dagger Lane Elstree, Hertfordshire UNITED KINGDOM

Chiron Corporation 4560 Horton Street Emeryville CA 94608-2916

Kamada, Ltd. 7 Sapir Street Ness Ziona ISRAEL

Kamada Ltd. Kiryat Weizmann ISRAEL

Kamada Ltd. Kiryat Weizmann ISRAEL

CSL Behring LLC 1020 First Avenue King of Prussia PA 19406 King of Prussia PA CSL Behring L.L.C. 1020 First Ave. PO Box 61501 19406-0901

The Mount Sinai School Fifth Avenue at 100th New York NY Desnick, Robert J. M.D. Of Medicine Street, Box 1203 10029

Convent Avenue & 138th New York NY David Calhoun, Ph.D. Department of Chemistry Street 10031 Shire Human Genetic Therapies, Inc. 700 Main Street Cambridge MA 02139 National Institute of Diabetes, National Institutes of and Digestive and Kidney Health, 31 Center Drive Bethesda MD Diseases MSC Building 31, Room 9N-222 20892-2560

Penwest Pharmaceuticals Danbury CT Company 39 Old Ridgebury Road Suite 11 06810

Schwarz Pharma, Inc. P.O. Box 2038 Milwaukee WI 53201 600 N. Wolfe St., Jefferson Baltimore MD Daniel F. Hanley, MD Johns Hopkins University 1-109 21287

Sanofi-Aventis US, Inc. 55 Corporate Drive Bridgewater NJ 08807

Ablynx NV Technologiepark 4 B-9052 Zwijnaarde BELGIUM

Thousand Oaks CA 91320- Amgen Inc. One Amgen Center Drive 1799

Medimmune Oncology, Inc. One MedImmune Way Gaithersburg MD 20878

Medimmune LLC One MedImmune Way Gaithersburg MD 20878

Medimmune, LLC One MedImmune Way Gaithersburg MD 20878

Medimmune LLC One MedImmune Way Gaithersburg MD 20878 Monmouth Junction NJ Transave, Inc. 11 Deer Park Drive 08852-1923 Research Glaxo Wellcome Research and Triangle Park Development 5 Moore Drive PO Box 13398 NC 27709 Department of 880 Kempsville Road, Norfolk VA Eastern Virginia Medical School Ophthalomology Suite 2500 23502-3990

DUSA Pharmaceuticals, Inc. 25 Upton Drive Wilmington MA 01887

Syncom Pharmaceuticals, Inc. 66 Hanover Road Florham Park NJ 07932

The Institute for One World Health 580 California Street San Francisco CA 94104

University of Illinois at 833 South Wood Street Chicago IL Kanyok, Thomas P. Pharm.D. Chicago College of Pharm (m/c886) Rm. 176 60612

University Of Illinois At 833 South Wood Street Chicago IL Kanyok, Thomas P. Pharm.D. Chicago College of Pharm (m/c886) Rm. 176 60612 University of Illinois at 833 South Wood Street Chicago IL Kanyok, Thomas P. Pharm.D. Chicago College of Pharm (m/c886) Rm. 176 60612

21 N. Skokie Valley Lake Bluff IL Academic Pharmaceuticals, Inc. Highway Suite G3 60044

Pipex Pharmaceuticals, Inc. 3930 Varsity Drive Ann Arbor MI 48108

Pipex Pharmaceuticals, Inc. 3930 Varsity Drive Ann Arbor MI 48108

Xanthus Pharmaceuticals, Inc. 300 Technology Square Cambridge MA 02139

Novartis Pharmaceuticals Corporation 150 Industrial Road San Carlos CA 94070

The Liposome Company, Inc. One Research Way Princeton NJ 08540

The Liposome Company, Inc. One Research Way Princeton NJ 08540

The Liposome Company, Inc. One Research Way Princeton NJ 08540

The Liposome Company, Inc. One Research Way Princeton NJ 08540

The Liposome Company, Inc. One Research Way Princeton NJ 08540 Overland Park KS Celgene Corporation 9900 W. 109th Street Suite 300 66210 Parke-Davis Pharmaceutical Research Ann Arbor MI Warner-Lambert Company Division 2800 Plymouth Road 48106

Akorn, Inc. 2500 Millbrook Drive Buffalo Grove IL 60089

Eatontown NJ Roberts Pharmaceutical Corp. Meridian Center II 4 Industrial Way West 07724-2274

Eatontown NJ Roberts Pharmaceutical Corp. Meridian Center II 4 Industrial Way West 07724-2274 Genzyme Corporation One Kendall Square Cambridge MA 02139

Scios, Inc. 2450 Bayshore Parkway Mountain View CA 94043

Scios, Inc. 2450 Bayshore Parkway Mountain View CA 94043 San Mateo 400 South El Camino CA 94402- Xytis, Inc. Real Suite 1200 1703

3000 Continental Dr., Knoll Pharmaceutical Company North Mt. Olive NJ 07828

Maret Pharmaceutical 4041 MacArthur Corporation Boulevard, Suite 375 Newport Beach CA 92660 Newport Beach CA Maret Pharmaceuticals 4041 MacArthur Blvd. Suite 375 92660

Cangene Corporation 155 Innovation Drive R3T 5Y3 CANADA

Novartis Pharmaceuticals Corporation One Health Plaza East Hanover NJ 07936

Xoma Corporation 2910 Seventh Street Berkeley CA 94710

Xoma Corporation 2910 Seventh Street Berkeley CA 94710 Chief Medical Officer, VP, Quebec G1P AEterna Zentaris, Inc. Dr. Claude Hariton Cli 4P5, Canada CANADA San Diego Biogen IDEC, Inc. 5200 Research Place CA 92122

Xencor, Inc. 111 W. Lemon Avenue Monrovia CA 91016

21823 30th Drive Seattle Genetics, Inc. Southeast Bothell WA 98021

Baxter Healthcare Corporation 1620 Waukegan Road Mcgaw Park IL 60085 Xenova Biomedix Limited CELTIC PHARMA 957 Buckingham Avenue Berkshire SL1 4NL UNITED KINGDOM

Biomedical Research Institute 345 North Smith Avenue St. Paul MN 55102

Biomedical Research Institute 345 North Smith Avenue St. Paul MN 55102

Biomedical Research Institute 345 North Smith Avenue St. Paul MN 55102

Biomedical Research Institute 345 North Smith Avenue St. Paul MN 55102 Pfizer Global Research & Development 50 Pequot Avenue New London CT 06320

Children's Hospital 700 Children's Drive Columbus OH 43205

Bayer HealthCare LLC 555 Whiteplains Road Tarrytown NY 10591-5124 Woodland 6355 Topanga Canyon Hills CA Advanced Biotherapy, Inc. Blvd. Suite 510 91367

Xoma Corporation 2910 Seventh Street Berkeley CA 94710

Xoma Corporation 2910 Seventh Street Berkeley CA 94710

Burzynski Research Institute, Inc. 9432 Old Katy Road Houston TX 77055

Upsher-Smith Laboratories, Inc 4905 23rd Avenue North Minneapolis MN 55447

Lorus Therapeutics, Inc. 2 Meridan Road M9W 4Z7 CANADA

Lorus Therapeutics, Inc 2 Meridan Road M9W427 CANADA Waltham MA Genzyme Corporation Drug & Biomaterial R&D 153 Second Avenue 02451

10505 Sorrento Valley CoDa Therapeutics, Inc. Road San Diego CA 92121

Tolera Therapeutics, Inc. 4717 Campus Drive #800 Kalamazoo MI 49008

Xoma Corporation 2910 Seventh Street Berkeley CA 94710

9900 Corporate Campus Louisville KY Bradmer Pharmaceuticals, Inc. Drive Suite 3000 40223 King of Prussia PA CSL Behring 1020 First Ave. PO Box 61501 19406-0901 9312 Old Georgetown American National Red Cross Road Bethesda MD 20814

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

Applied Medical Research 1600 Hayes Street Nashville TN 37203

Fresenius Biotech North America 920 Winter Street Waltham MA 02451

Rare Disease Therapeutics, Inc. 2550 Meridian Blvd Franklin TN 37067

5445 East Cheryl Ophidian Pharmaceuticals, Inc. Parkway Madison WI 53711

Archemix Corporation 300 Third Street Cambridge MA 02142

Cambridge MA 02139- Ariad Pharmaceuticals, Inc. 26 Landsdowne St. 4234 Wyeth-Lederle Vaccines and West Henrietta NY 14586- Pediatrics 211 Bailey Rd. 9728

Scherer DDS Frankland Road Swindon SN5 8RU Wiltshire UNITED KINGDOM

Buffalo Grove Pentech Pharmaceuticals, Inc. 1110 Lake Cook Rd. Suite 257 IL 60089 NeuroHealing Pharmaceuticals, Inc. 50 Undine Road Newton MA 02135

Immtech Pharmaceuticals, Inc. 150 Fairway Drive Vernon Hills IL 60061

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

MolMed S.p.A. Via Olgettina 58 Milan ITALY

Cambridge MA 02139- Vertex Pharmaceuticals Inc. 130 Waverly Street 4242

Boston MA Perrine, Susan P., M.D. Boston University Cancer Research Center 02118

San Diego CytRx Corporation 3030 Bunker Hill Street Suite 105 CA 92109

University of Cincinnati P. O. Box 670669 231 Cincinnati OH Floyd R. Sallee, M.D., Ph.D. School of Medicine/ Albert Sabin Way 45267-0559

Cephalon, Inc. 41 Moores Road Frazer PA 19355

Frazer PA Cephalon Inc 41 Moores Road P. O. Box 4011 19355

Cephalon, Inc. 41 Moores Road Frazer PA 19355

Cephalon, Inc. 41 Moores Road Frazer PA 19355 Cephalon, Inc. 41 Moores Road Frazer PA 19355

Cephalon, Inc. 41 Moores Road Frazer PA 19355

Frazer PA Cephalon, Inc. 41 Moores Road P.O. Box 4011 East19355 Hanover NJ 07936- Novartis Pharmaceuticals Bldg 405/4051 One Health Plaza 1080 Special Programme for Research and Training in World Health Organization Tro Via Appia , Geneva 27 SWITZERLAND Ft. Detrick US Army Medical Materiel Office of the Surgeon MD 21702- Development Activity General 622 Neiman Street 9240

Shire Human Genetic Therapies, Inc. 700 Main Street Cambridge MA 02139

NPDC-AS101, Inc. 783 Jersey Avenue New Brunswick NJ 08901

McGuff Pharmaceuticals Inc. 2921 W. McArthur Blvd. Santa Ana CA 92704-6929

Eli Lilly & Company Lilly Corporate Center Indianapolis IN 46285 Research Triangle Park GlaxoSmithKline, Inc. 5 Moore Drive PO Box 13398 ResearchNC 27709 Triangle Park GlaxoSmithKline, Inc. 5 Moore Drive PO Box 13398 NC 27709-

TVAX Biomedical, LLC 8060 Reeder Street Lenexa KS 66214-1554

Dendreon Corporation 3005 First Avenue Seattle WA 98121

Cellular Bioengineering, Inc. 1946 Young Street Honolulu HI 96826 Bothell WA Northwest Biotherapeutics, Inc. 22322 20th Avenue SE Suite 150 Overland98021 9200 Indian Creek Park KS Avax Technologies, Inc. Parkway Building 9, Suite 200 66210

Los Angeles Proneuron Biotechnologies, Inc. 2029 Century Park East Sixth Floor CA 90067 Montreal (Quebec) H4S Kiadis Pharma Canada, Inc. 2525 Marie Curie 2E1 CANADA

RhinoCyte, Inc. 201 E. Jefferson Street Louisville KY 40202-1246

RhinoCyte, Inc. 201 E. Jefferson Street Louisville KY 40202-1246

TissueTech, Inc. 7000 SW 97th Avenue Miami FL 33173

Antigenics, Inc. 3 Forbes Rd. Lexington MA 02421

Antigenics, Inc. 3 Forbes Rd. l MA 02421

Princeton NJ Cytogen Corporation 600 College Road East CN 5308 08540-5308

Biogen Idec MA, Inc. 14 Cambridge Center Cambridge MA 02142

10646 Science Center Pfizer, Inc. Drive San Diego CA 92121

787 Seventh Ave., 48th Oral Solutions, Inc. Floor New York NY 10019

Gilead Sciences (formerly Corus Seattle WA Pharma) 2025 First Ave. Suite 800 98121 Pacific Palisades CA OncoVac Corporation P. O. Box 970 90272 Fort Lee NJ A. L. Laboratories, Inc. One Executive Drive P.O. Box 1399 07024

Infusaid, Inc. 1400 Providence Highway Norwood MA 02062 Minneapolis MN 55440- Medtronic, Inc. 800 53rd Avenue N.E. P.O. 1250 9087

710 Medtronic Parkway Minneapolis MN 55432- Medtronic Neurological NE 5604

Reata Pharmaceuticals, Inc. 2801 Gateway Drive Irving TX 75063

Eurand Pharmaceuticals, Inc. 790 Township Line Road Yardley PA 19067

Princeton NJ DOR BioPharma, Inc. 29 Emmons Drive Suite C-10 08540

Princeton NJ DOR BioPharma, Inc. 29 Emmons Drive Suite C-10 08540

Princeton NJ DOR BioPharma, Inc. 29 Emmons Drive Suite C-10 08540

Bristol-Myers Squibb Company P. O. Box 4000 Princeton NJ 08543-4000

Fallien Cosmeceuticals Ltd. 677 W. Dekalb Pike King of Prussia PA 19406

Angelini Pharmaceuticals, Inc. 70 Grand Avenue River Edge NJ 07661 West Hanford CT 06119- AllerQuest LLC 836 Farmington Avenue Suite 207 1551

Ross Laboratories 625 Cleveland Avenue Columbus OH 43215

LungRx, Inc. 1104 Spring Street Silver Spring MD 20910 Bldg. 337, Paint Branch Dovetail Technologies, Inc. Drive College Park MD 20742 Bldg. 337, Paint Branch Dovetail Technologies, Inc. Drive College Park MD 20742

University of Cincinnati Cincinnati OH Floyd R. Sallee, M.D., Ph.D. School of Medicine ML 0559 45267-0559

Los Angeles Medco Research, Inc. 8455 Beverly Blvd. Suite 308 CA 90048

Los Angeles Medco Research, Inc. 8455 Beverly Blvd. Suite 308 CA 90048 Advanced Life Sciences, Inc. (ALS) 1440 Davey Road Woodridge IL 60517

South San Francisco CA Genentech, Inc. 1 DNA Way 94080-4990 South San Francisco CA Genentech, Inc. 1 DNA Way 94080-4990 South San Francisco CA Genentech, Inc. 1 DNA Way, MS #242 94080-4990

South San Francisco CA Genentech, Inc. 1 DNA Way 94080-4990

Cork Airport Business Alimentary Health Limited Park, Building 2800 Cork IRELAND

Alimentary Health Limited Guardwell, Kinsale County Cork IRELAND

River Edge Angelini Pharmaceuticals, Inc. 70 Grand Avenue Suite 109 NJ 07661

Oakdale MN Excorp Medical, Inc. Suite 235 7200 Hudson Blvd. 55128

TissueTech, Inc. 7000 SW 97th Avenue Miami FL 33173

Durham NC ICAgen Inc. Ion Channel Advances PO Box 14487 27709 MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

The Medicines Company 8 Sylvan Way Parsippany NJ 07054

11199 Sorrento Valley Genetronics, Inc. Rd. San Diego CA 92121-1334

Bristol-Myers Squibb 5 Research Parkway Wallingford CT 06492

Actelion Pharmaceuticals Ltd Gewerbestrasse 16 CH-4123 SWITZERLAND

Wyeth Pharmaceuticals, Inc. 87 Cambridge Park Drive Cambridge MA 02140

Ipsen Limited 1 Bath Rd., Maidenhead Berkshire SL6 4UH UNITED KINGDOM

Berkshire, Ipsen Biopharm Limited 1 Bath Road Maidenhead SL6 4UH UNITED KINGDOM

1155 15th Street, N.W., Porton International, Inc. #315 Washington DC 20005

Irvine CA Allergan, Inc. 2525 Dupont Drive P.O. Box 19534 92623-9534 Botulinum Toxin Research 1261 Furnace Brook Associates, Inc. Parkway Quincy MA 02169

Ipsen Limited 27 Maple Street Milford MA 01757-3650 Ipsen Limited (name changed from Porton International Inc) 27 Maple Street Milford MA 01757-3650

1030 North Parkview Hastings, Donald DVM Drive Bismarck ND 58501

4001 Lexington Avenue GalaGen, Inc. North Arden Hills MN 55126

540 Arapeen Drive, Suite Biomune Systems, Inc. 202 Salt Lake City UT 84108

One Gustave L. Levy Mount Sinai Medical Center Place New York NY 10029

Irvine CA Allergan, Inc. 2525 Dupont Dr. P.O. Box 19534 92623-9534

UCB Pharma, Inc. 1950 Lake Park Drive Smyra GA 30080

SciClone Pharmaceuticals, Inc. 901 Mariner's Island Blvd. San Mateo CA 94404

Boehringer Ingelheim 900 Ridgebury Road, Box Pharmaceuticals, Inc. 368 Ridgefield CT 06877-0368

225 East Deerpath, Suite NeoPharm, Inc. 250 Lake Forest IL 60045

GPC Biotech, Inc. 610 Lincoln Street Waltham MA 02451

Digestive Care, Inc. 1120 Win Drive Bethlehem PA 18017

One New England Alpha Pharmaceuticals, LLC Avenue Piscataway NJ 08854 Sparta Pharmaceuticals, Inc. 111 Rock Road Horsham PA 19044-2310

SuperGen, Inc. 4140 Dublin Boulevard Dublin CA 94568

Dublin CA SuperGen, Inc. 4140 Dublin Blvd Suite 200 94568 Two Annabel Lane, Suite SuperGen, Inc. 220 San Ramon CA 94583 USC-CHLA Institute for Childrens Hospital of Los Pediatric Clinical Research Angeles MS 55 Los Angeles CA 90027

USC-CHLA Institute for Childrens Hospital of Los Los Angeles Pediatric Clinical Research Angeles 4650 Sunset Blvd, MS 55 CA 90027

Shire Laboratories Inc. 1550 East Gude Drive Rockville MD 20850

Shire Laboratories Inc. 1550 East Gude Drive Rockville MD 20850 Triangle Pk Burroughs Wellcome Company 3030 Cornwallis Road P.O. Box 12700 NC 27709

Alpha Therapeutic Corporation 5555 Valley Boulevard Los Angeles CA 90032 King of Prussia PA CSL Behring L.L.C. 1020 First Ave. PO Box 61501 19406-0901

Westlake Village CA Baxter Healthcare Corp. One Baxter Way 91362

Hyland Division (Baxter Glendale CA Baxter Healthcare Corp. Hyland) 550 North Brand Blvd. 91203

21823 30th Drive Seattle Genetics, Inc. Southeast Bothell WA 98021

Sandoz Pharmaceuticals Corp. 59 Route 10 East Hanover NJ 07936 28101 Ballard Road, Suite Pharmedic Company F Lake Forest IL 60045

R & D Laboratories, Inc. 4204 Glencoe Avenue Marina Del Rey CA 90292 Highland Beach FL Calgonate Corp. 3310 South Ocean Blvd Unit 132 33487 Highland Beach FL Calgonate Corporation 3310 South Ocean Blvd Unit 132 33487

3940 Quebec Avenue Paddock Laboratories, Inc. North Minneapolis MN 55427 Amherst NY Pneuma Pharmaceuticals, Inc. 1576 Sweet Home Road Suite 114 14228 Novartis Pharmaceuticals East Hanover NJ 07936- Corporation One Health Plaza 1080

TheraQuest Biosciences, LLC 146 Medinah Drive Blue Bell PA 19422-3212

South San Francisco CA Anesiva, Inc. 650 Gateway Blvd 94080

NeurogesX, Inc. 981F Industrial Road San Carlos CA 94070 San Carols CA 94070- NeurogesX, Inc. San Carlos Business Park 981F Industrial Road 4117

Orphan Europe Immeuble "Le Guillaumet" Cedex 70 FRANCE

INO Therapeutics 6 Route 173 Clinton NJ 08809

Research Triangle Park NC Glaxo Wellcome Inc. 5 Moore Drive 27709

Avenids Carlos III de Digna Biotech, S.L. Noble Pamplona (Navarra) SPAIN South San Francisco CA Proteolix, Inc. 333 Allerton Avenue 94080

Redwood CA Direct Therapeutics, Inc. 460 Seaport Court Suite 220 94063

Intramed Corporation 102 Tremont Way Augusta GA 30907

Fresenius Biotech North America, Inc. 99 Hayden Avenue Lexington MA 02420-9192

Route 23 & Woodmont SmithKline Beecham Ave., P.O. Box 1510 King Of Prussia PA 19406

Xoma Corporation 2910 Seventh Street Berkeley CA 94710

Celltech Chiroscience Limited 216 Bath Road Slough SL1 4EN UNITED KINGDOM

Pfizer Global Research & New London Development MS 6025-B4179 50 Pequot Avenue CT 06320 Merit E. Cudkowicz, MD, Building 149 13th Street, Charlestown Mass General Hospital MSc Room 2274 MA 02129

Aastrom Biosciences Incorporated P.O. Box 376 Ann Arbor MI 48106

Eleos, Inc. 3033 Campus Drive Plymouth MN 55441

Eleos, Inc. 7824 Jackson Street Omaha NE 68114 One Valmont Plaza - Eleos, Inc. Corporate Headquarters Omaha NE 68154

Calzada de Tlalpan No. Istituto Bioclon S.A. de C.V. 4687 Tlalpan MEXICO

Advanced LIfe Sciences, Inc. 1440 Davey Road Woodridge IL 60517

Baker Cummins Pharmaceuticals, Inc. ImClone Systems Incorporated 33 ImClone Drive Branchburg NJ 08876

Dr. Falk Pharma GmbH Leinenweberstrasse 5 9041 Freiburg, GERMANY GERMANY Sigma-Tau Pharmaceuticals, Gaithersburg Inc. 9841 Washingtonian Blvd Suite 500 MD 20878

Wilex Biotechnology GmbH Grillparzerstrasse 10B 81675 Munich GERMANY

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355-1307

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355-1307

Montreal, Quebec, H4S Thallion Pharmaceuticals, Inc. 7150 Alexander-Fleming 2C8 CANADA

Morphotek, Inc. 210 Welsh Pool Road Exton PA 19341

Centocor, Inc. 244 Great Valley Parkway Malvern PA 19355

CSl Limited 45 Poplar Road AUSTRALIA

Biosynexus, Inc. 9298 Gaither Road Rockville MD 20877

Sharon Wood Technical 11370 Reed Hartman Cincinnati OH Procter & Gamble Company Center Highway 45241

TransMolecular, Inc. 840 Memorial Drive Cambridge MA 02139

TransMolecular, Inc. 840 Memorial Drive Cambridge MA 02139

Parc scientifique de Trophos SA Luminy 13288 Marseille cedex FRANCE Cincinnati Children's Hospital Cincinnati OH Medical Center 3333 Burnet Ave. MLC 5006 45229-3039 Feinberg School of Alan L. Buchman, M.D., Medicine, Dept. of 676 N. St. Clair St., Suite Chicago IL M.S.P.H. Gastroentero 1400 60611

Lake Forest Bioniche Pharma USA LLC 272 E. Deerpath Road Suite 304 IL 60045

Curis, Inc. 61 Moulton Street Cambridge MA 02138

Bausch & Lomb Pharmaceuticals, Inc. 8500 Hidden River Pkwy. Tampa FL 33637

Westminster Gilead Sciences, Inc. 77575 W. 103rd Avenue Suite 102 CO 80021

EMD Serono, Inc. One Technology Place Rockland MA 02370 777 Old Saw Mill River Regeneron Pharmaceuticals Inc Road Tarrytown NY 10591

Syntex-Synergen Neuroscience 3200 Walnut Street Boulder CO 80301

Syntex-Synergen Neuroscience 3200 Walnut Street Boulder CO 80301

Monmouth Junction NJ Transave, Inc. 11 Deer Park Drive 08852-1923

Matrix Pharmaceutical, Inc. 34700 Campus Drive Fremont CA 94555-3612

Matrix Pharmaceutical, Inc. 34700 Campus Drive Fremont CA 94555-3612

100 Fairway Drive, Suite Winston Laboratories, Inc. 134 Vernon Hills IL 60061 Johnson & Johnson Ortho Biotech Oncology Pharmaceutical Research Raritan NJ Research & Development & Dev., 920 US Highway 202 08869

Unit of J & J Ortho Biotech Oncology Pharmaceutical Research Raritan NJ Research & Development & Developmen P. O. Box 300 08869 Johnson & Johnson Raritan NJ Pharmaceutical R & D, LLC 920 Route 202 PO Box 300 08869-0602 Unit of J & J Ortho Biotech Oncology Pharmaceutical Research 920 Route 202 South, P.O. Raritan NJ Research & Development & Dev., LLC Box 300 08869-0602

Actelion Pharmaceuticals Ltd. Gewerbestrasse 16 SWITZERLAND

New York NY Pfizer Inc. 235 East 42nd Street 150-3-46 10017 Kalamazoo MI 49001- Pharmacia & Upjohn 7000 Portage Road Unit 0633-298-113 0199

Autoimmunity Research Foundation 3423 Hill Canyon Avenue Thousand Oaks CA 91360

Lundbeck, Inc. Four Parkway North Deerfield IL 60015

Genzyme Corp (Ilex Products, San Antonio TX 78229- Inc.) 4545 Horizon Hill Blvd. 2263

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Jazz Pharmaceuticals, Inc. 3180 Porter Drive Palo Alto CA 94304

40 Valley Stream Auxilium Pharmaceuticals, Inc. Parkway Malvern PA 19335

New York NY Effective Pharmaceuticals, Inc. 150 Broadway Suite 1800 10038

EnVivo Pharmaceuticals, Inc. 480 Arsenal Street Watertown MA 02472

300 Longwood Avenue, Boston MA Brugnara, Carlo M.D. The Children's Hospital Bader 760 02115

Berkeley Heights NJ Genta, Inc. Two Connell Drive 07922 Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

Sucampo Pharma Americas, Bethesda MD Inc. 4520 East-West Highway Third Floor 20814

Allermed Labortories, Inc. 7203 Convoy Court San Diego CA 92111

Integrative Therapeutics, Inc. 825 Challenger Drive Green Bay WI 54311

AR Scientific, Inc. 1100 Orthodox Street Philadelphia PA 19124

AR Scientific, Inc. 1100 Orthodox Street Philadelphia PA 19124

661 Palisade Ave., P.O. Pharmacontrol Corporation Box 931 Englewood Cliffs NJ 07632

40 Valley Stream Auxilium Pharmaceuticals, Inc. Parkway Malvern PA 19355

OXiGENE, Inc. 230 Third Avenue Waltham MA 02451

OXiGENE, Inc 321 Arsenal Street Watertown MA 02472

Xenova Biomedix Limited 957 Budkingham Avenue Slough UNITED KINGDOM

Los Angeles CA 90035- Jarrow Formulas, Inc. 1824 S. Robertson Blvd. 4317

Cognetix, Inc. 421 Wakara Way Salt Lake City UT 84108 OncoVista, Inc. 14785 Omicron Drive San Antonio TX 78245

Neurobiological Technologies, Inc. 1387 Marina Way South Richmond CA 94804

Drossapharm LTD 4002 Basel SWITZERLAND

Viralytics Limited P. O. Box 1045 Pymble Business Centre AUSTRALIA

Avicena Group, Inc. 228 Hamilton Avenue Palo Alto CA 94301 San Francisco CA Avicena Group, Inc. 580 California St. Suite 1600 94104

University of California, San Aroian Laboratory, Div. of LaJolla CA Diego Biological Sciences Department 0322 92093-0322

ImmuCell Corporation 56 Evergreen Drive Portland ME 04103

Division of Pediatric Durham NC Duke University Medical Center Allergy & Immunology Erwin Road 27710

Cytel Corporation 3525 John Hopkins Court San Diego CA 92121

Cytel Corporation 3525 John Hopkins Court San Diego CA 92121

Cytel Corporation 3525 John Hopkins Court San Diego CA 92121

Hoarborside Financial Jersey City Lux Biosciences, Inc. Center Plaza 10, 14th Floor NJ 07302 Tecnology Ventures Albuquerque Maas Biolab,LLC Corporation Technopolis 1155 University Blvd., SE NM 87106

Sigmoid Pharma Limited Dublin City University IRELAND Sigmoid Pharma Limited Dublin City University IRELAND

Burlingame APT Pharmaceuticals, Inc. 700 Airport Blvd. Suite 350 CA 94010

Burlingame APT Pharmaceuticals, Inc. 700 Airport Blvd. Suite 350 CA 94010

Irvine CA Allergan, Inc. 2525 Dupont Drive P.O. Box 19534 92623-9534

Irvine CA Allergan, Inc. 2525 Dupont Drive P.O. Box 19534 92623-9534

NOVAGALI Pharma SA Batiment Genavenir IV F-91058-Evry cedex FRANCE

Novagali Pharma S.A. 1 rue Pierre Fontaine 91058 Evry cedex FRANCE

Novagali Pharma S.A. 1 rue Pierre Fontaine 91058 Evry cedex FRANCE

Harborside Financial Jersey City Lux Biosciences, Inc. Center Plaza 10, 14th Floor NJ 07302

200 Westpark Corporate Durham NC RTP Pharma Corporation Center 4364 South Alston Avenue 27713-2280 College Of Veterinary Department of Small Athens GA University Of Georgia Medicine Animal Medicine 30602

Berlex Laboratories, Inc. 300 Fairfield Road Wayne NJ 07470

Adherex Technologies, Inc. 4620 Creekstone Drive Durham NC 27703

Bennu Pharmaceuticals, Inc. (dual EMEA) 9 Commercial Blvd. Novato CA 94949

Bennu Pharmaceuticals 9 Commerical Blvd Novato CA 94949 University of Michigan Ann Arbor MI Thoene, Jess G., M.D. Medical School 300 NIB, 1192 SE 48109-0408 Sigma-Tau Pharmaceuticals, Gaithersburg Inc. 9841 Washingtonian Blvd Suite 500 MD 20878 Framingham MA 01701- Genzyme Corporation One Mountain Rd. P.O. Box 9322 9322

GenVec, Inc. 12111 Parklawn Drive Rockville MD 20852 Framingham MA 01701- Genzyme Corporation One Mountain Road P.O. Box 9322 9322

Genetic Therapy, Inc. 938 Clopper Road Gaithersburg MD 20878

Medical University of 96 Jonathan Lucas Street, Charleston Bruce Frankel, MD South Carolina Suite 428 CSB SC 29425

Celator Pharmaceuticals, Inc. 303 B College Road East Princeton NJ 08540

10390 Pacific Center Vical Inc. Court San Diego CA 92121

10390 Pacific Center Vical Incorporated Court San Diego CA 92121

Pharmaceutical Division, New Haven Bayer Corporation Biological Products 400 Morgan Lane CT 06516

Norwich Eaton Pharmaceuticals P.O. Box 191 Norwich NY 13815

Jacobus Pharmaceutical Princeton NJ Company, Inc. 37 Cleveland Lane P.O. Box 5290 08540

Jacobus Pharmaceutical Princeton NJ Company 37 Cleveland Lane P.O. Box 5290 08540

Jacobus Pharmaceutical Princeton NJ Company 37 Cleveland Lane P.O. Box 5290 08540 Diatos USA, LLC 15310 Amberly Drive Tampa FL 33647 Via Pian Scairolo, 6912 Helsinn Healthcare SA Pazzallo Lugano SWITZERLAND

MediWound, Ltd. 3, Azrieli Center Tel-Aviv 67023 ISRAEL

Eisai Medical Research, Inc. 6611 Tributary Street Baltimore MD 21224-6515

Eisai Medical Research, Inc. 6611 Tributary Street Baltimore MD 21224-6515 Baltimore MD Eisai Medical Research, Inc. 6611 Tributary Street Suite 200 21224-6515

ApoPharma, Inc. 200 Barmac Drive CANADA

ApoPharma, Inc. A Division of Apotex Research Inc. Toronto, Canada M9L 1T9 CANADA

Biomedical Frontiers, Inc. 1095 10th Avenue, SE Minneapolis MN 55414

Gentium SpA Piazza XX Settembre, 2 ITALY

Gentium SpA Piazza XX Settembre, 2 22079 Villa Guardia (CO) ITALY

Crinos International Via Belvedere 1 Villa Guardia, Italy 22079

Genelabs Technologies, Inc. 505 Penobscot Drive Redwood City CA 94063

6111 Royalmount Quebec H4P Paladin Labs, Inc. Avenue, Suite 102 Montreal 2T4 CANADA

Salt Lake City UT 84109- Pharmadigm, Inc. 2401 Foothill Drive 1405 Salt Lake City UT 84109- Pharmadigm, Inc. 2401 Foothill Drive 1405

Eatontown NJ Roberts Pharmaceutical Corp. Meridian Center II Four Industrial Way West 07724-2274

Cambridge MA 02139- Peptimmune, Inc. 64 Sidney Street 4170

Irvine CA Allergan 2525 Dupont Drive P. O. Box 19534 92623-9534

EyeGate Phardmaceuticals, Inc. 100 Beaver Street Waltham MA 02453 Iselin NJ Pharmos Corporation 99 Wood Avenue Suite 311 08830 Toronto, Ontario M4P BCY LifeSciences Inc. 160 Eglinton Ave. East Suite 600 3B CANADA

Holles Laboratories, Inc. 30 Forest Notch Cohasset MA 02025

Biomedical Frontiers, Inc. 1095 10th Avenue S.E. Minneapolis MN 55414

University Of Utah 50 North Medical Drive, Salt Lake City Kennedy & Hoidal, M.D.'s Medical Center Room 4R240 UT 84132 Ueno Fine Chemicals Industry, 2-31 Koraibashi, Higashi- Ltd. ku Osaka 541 JAPAN

Clinical Research & Valley Forge Luitpold Pharmaceuticals, Inc.. Development 800 Adams Avenue PA 19403

Valley Forge Luitpold Pharmaceuticals, Inc. 800 Adams Avenue 1st Floor PA 19403

Clinical Research and Valley Forge Luitpold Pharmaceuticals, Inc.. Development 800 Adams Avenue PA 19403

Baxter Healthcare Corporation 1620 Waukegan Road McGaw Park IL 60085 2800 Plymouth Rd., P.O. Warner-Lambert Company Box 1047 Ann Arbor MI 48106

2400 West Lloyd Bristol-Myers Squibb Expressway Evansville IN 47721

Connaught Laboratories Route 611, P.O. Box 187 Swiftwater PA 18370

CIS-US 10 DeAngelo Drive Bedford MA 01730

Genzyme Corporation 153 Second Avenue Waltham MA 02451

Allertein Therapeutics, LLC 640 Sasco Hill Road Fairfield CT 06824

9314 E. Broadway Sirion Therapeutics, Inc. Avenue Tampa FL 33619

Bette S. Pollard, LLC 11008 Lamplighter Lane Potomac MD 20854

PrimeCyte, Inc. 130 Fifth Ave., N. Seattle WA 98109-4933

PrimeCyte, Inc. 130 Fifth Ave., N. Seattle WA 98109-4933

Boehringer Mannheim Corp. 1301 Piccard Drive Rockville MD 20850

Gaithersburg Sigma-Tau Research, Inc. 9841 Washingtonian Blvd Suite 502 MD 20878

Herndon VA Besins Internaitonal, US Inc. 610 Herndon Parkway Suite 750 20170

Abela Pharmaceuticals, Inc. 21581 Midcrest Drive Lake Forest CA 92630

Abela Pharmaceuticals, Inc. 21581 Midcrest Drive Lake Forest CA 92630 Research Industries Corp. Tucson AZ Cancer Technologies, Inc. 7301 East 22nd Street Suite 10E 85710

Tucson AZ Cancer Technologies, Inc. 7301 East 22nd Street Suite 10E 85710

Forum Products, Inc. 33 Flying Point Road Southampton NY 11968

Nashville TN Lloyd E. King, Jr. 1900 Patterson Street Suite 104 37203

ImmunoTherapeutics, Inc. 3505 Riverview Circle Moorhead MN 56560

Discovery Experimental & Development, Inc. 29949 S.R. 54 West Wesley Chapel FL 33543

103 Carnegie Center, Anthra Pharmaceuticals, Inc. Suite 102 Princeton NJ 08540

Pharmaquest Corporation 4470 Redwood Highway San Rafael CA 94903

DNage B.V. Darwinweg 24 NETHERLANDS

DuPont Pharmaceuticals Wilmington Company Chestnut Run, Maple Run Centre Rd. DE 19805

Expression Genetics, Inc. 2215 Mock Road Huntsville AL 35801 San Diego CA 92121- Vical Incorporated 9373 Towne Center Dr. Suite 100 3088 Overland 9200 Indian Creek Park KS AVAX Technologies, Inc. Parkway Building 9, Suite 200 66210

Valley Forge Luitpold Pharmaceuticals, Inc. 800 Adams Avenue 1st Floor PA 19403 Johnson & Johnson Pharmaceutical Research & Raritan NJ Dev. 920 US Highway 202 P. O. Box 300 08869

Novartis Pharmaceuticals East Hanover NJ 07936- Corporation One Health Plaza 1080 Quebec H9S Supratek Pharma Inc. 215Bouchard Blvd Dorval 1A9 CANADA

59, Bd Gal Martial Valin - BioAlliance Pharma 75015 Paris FRANCE

Supratek Pharma, Inc. 215 Bouchard Blvd Dorval, Quebec H9S 1A9 CANADA

Pittsburgh PA Demegen, Inc. 100 Technology Drive Suite 440 B 15219

Thallion Pharmaceuticals, Inc. 7150 Alexander-Fleming H4S 2C8 Montreal CANADA

13950 Ballantyne Chelsea Therapeutics, Inc. Corporate Place Charlotte NC 28277

Chapel Hill Lantibio, Inc. 100 Europa Drive Suite 421 NC 27517

200 First Street Mayo Foundation Southwest Rochester MN 55905

200 First Street Mayo Foundation Southwest Rochester MN 55905

Dyax Corp 300 Technology Square Cambridge MA 02139

Alexion Pharmaceuticals, Inc. 352 Knotter Drive Cheshire CT 06410

Alexion Pharmaceuticals, Inc. 352 Knotter Drive Cheshire CT 06410

Alexion Pharmaceuticals, Inc. 352 Knotter Drive Cheshire CT 06410 East Hanover 59 Route 10/Bldg NJ 07936- Novartis Pharmaceuticals Corp. 122/N142 One Health Plaza 1080

Westminster Allos Therapeutics, Inc. 11080 CirclePoint Road Suite 200 CO 80020

VBL Pharmaceuticals, Inc. 216 Robin Way Menlo Park CA 94025

Marion Merrell Dow, Inc. P.O. Box 9627 Kansas City MO 64134

Upper Saddle River NJ Innapharma, Inc. 10 Mountainview Road 07458 Parke-Davis Pharmaceutical Research Ann Arbor MI Warner-Lambert Company Division 2800 Plymouth Road 48105 Santa Monica CA 90404- VivoRx 2825 Santa Monica Blvd. 2nd Floor 2429

Durham NC Adherex Technologies, Inc. 4620 Creekstone Drive Research Triangle Park 27703

G.D. Searle & Company 4901 Searle Parkway Skokie IL 60077

G.D. Searle & Company 4901 Searle Parkway Skokie IL 60077 Novato CA Raptor Therapeutics, Inc. 9 Commercial Boulevard Suite 200 94949-6118

Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285

Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285

Chiron Vision 500 Iolab Drive Claremont CA 91711 Ethicon, Inc. P.O. Box 151 Somerville NJ 08876 Johnson & Johnson Pharmaceutical Research & Raritan NJ Dev., 920 U.S. Highway Route 202, P.O. Box 300 08869-0602

R. W. Johnson Pharmaceutical Raritan NJ Research Institute Route 202 South P.O. Box 300 08869 Ortho Biotech Oncology Pharmaceutical R & D, Raritan NJ Research & Development LLC 920 US Highway 202 08869-0602

R. W. Johnson Pharmaceutical Research Institute Route 202, P.O. Box 300 Raritan NJ 08869

Chugai-USA, Inc. 3780 Hawthorn Court Waukegan IL 60087

Research Triangle Park NC Glaxo Wellcome Inc. 5 Moore Drive 27709

Upjohn Company 301 Henrietta Street Kalamazoo MI 49001

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

7220 Frederick Banting, Quebec H4S Neurochem, Inc. Suite 100 Saint-Laurent 2A1 CANADA

Center for Cell and Gene Houston TX Therapy Feigin Center Suite 1120 77030-2399

South San Francisco CA Genentech, Inc 1 DNA Way 94080-4990

Doylestown EUSA Pharma (US), Inc. 1980 South Easton Road Suite 250 PA 18901

Lyphomed, Inc. Organon Teknika Corporation

P.O. Box 516, 107/2 McDonnell Douglas Corp MS10 St. Louis MO 63166

Herndon VA Ascend Therapeutics, Inc. 607 Herndon Parkway Suite 110 21070

Immunex Corporation 51 University Street Seattle WA 98101-2936

Parc Technologique du 31521 Ramonville Saint Orfagen Canal Agne Cedex FRANCE

Parc Technologique du 31521 Ramonville Saint Orfagen Canal Agne Cedex FRANCE

Bio-Technology General Corp. 70 Wood Avenue, South Iselin NJ 08830

West Conshohocken PA U.S. Bioscience 100 Front Street 19428

Kings Park House, Polmaise Road, Stirling Laxdale Ltd. Laurelhill Business Park FK7 9JQ UNITED KINGDOM

Bloomington 6300 West Old Shakoppe MN 55438- MGI Pharma, Inc. Rd. Suite 110 2318 Bloomington 6300 West Old Shakoppe MN 55438- MGI Pharma, Inc. Rd. Suite 110 2318

Two Annabel Lane, Suite SuperGen, Inc. 220 San Ramon CA 94583

Two Annabel Lane, Suite San Ramon SuperGen, Inc. 220 Suite 10 CA 94583

Novartis Pharmaceuticals East Hanover NJ 07936- Corporation One Health Plaza 1080 Osiris Therpeutics, Inc. 2001 Aliceanna Street Baltimore MD 21231-3043

Melville NY OSI Pharmaceuticals, Inc. 58 South Service Road Suite 110 11747

Novo Nordisk Pharmaceuticals, INc. 100 College Road West Princeton NJ 08540

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

King of Prussia PA CSL Behring L.L.C. 1020 First Ave. PO Box 61501 19406-0901

Zymogenetics, Inc. 4225 Roosevelt Way Seattle WA 98105

Acorda Therapeutics 15 Skyline Dr. Hawthorne NY 10532

Acorda Therapeutics, Inc. 15 Skyline Dr. Hawthorne NY 10532 Leatherhead, Surrey KT22 Neuropharm, Ltd. Fetcham Park House 9HD UNITED KINGDOM

Cancer Research UK 61 Lincoln's Inn Fields London WC2A 3PX UNITED KINGDOM

USC-CHLA Institute for Childrens Hospital Los Los Angeles Pediatric Clinical Research Angeles 4650 Sunset Blve, MS 55 CA 90027

Degussa AG Weissfrauenstr.9 D-60287 Frankfurt GERMANY

Oclassen Pharmaceuticals, Inc. 100 Pelican Way San Rafael CA 94901

Alpha Therapeutic Corporation 5555 Valley Boulevard Los Angeles CA 90032

Melville Biologics, Inc. 310 East 67th Street New York NY 10021 Chiron Vision 9342 Jeronimo Road Irvine CA 92718

Amgen, Inc. 1840 Dehavilland Drive Thousand Oaks CA 91320

Thousand Oaks CA 91320- Amgen, Inc. One Amgen Center Dr. 1799

Franco Muggia, M.D. 160 East 34th Street New York NY 10016

Richmond CA Berlex Laboratories, Inc. 15049 San Pablo Avenue P.O. Box 4099 94804-0099 Westport CT Farmacon, Inc. Post House, Suite 213 1720 Post Road East 06880-5643

Titusville NJ Janssen Research Foundation P.O. Box 200 08560

Division of American Pearl River Lederle Laboratories Cyanamid Company 401 N. Middletown Road NY 10965

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110-1199

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110-1199

194 Bureaux de la Colline Ethypharm SA - Batiment D 92213 Saint-Cloud Cedex

Neuropharm, Ltd. Felcham Park House Lower Road, Leatherhead UNITED KINGDOM

The Mount Sinai School New York NY Hollander, Eric MD of Medicine One Gustave L. Levy Place 10029-6574

Gilead Sciences, Ince. 2025 First Avenue Seattle WA 98121

Questcor Pharmaceuticals, Inc. 3260 Whipple Road Union City CA 94587-1217 The Cure Our Children Pacific Palisades CA Foundation 1730 Michael Lane 90272-2037

200 Great Vallley Centocor, Inc. Parkway Malvern PA 19355-1307

Topo Target A/S Symbion Science Park Fruebjergvej 3 DENMARK South San Francisco CA Receptor BioLogix, Inc. 1140 Veterans Blvd. Suite A 94080 South San Francisco CA Receptor BioLogix, Inc. 1140 Veterans Blvd. Suite A 94080 Parke-Davis Pharmaceutical Research Ann Arbor MI Warner-Lambert Company Division 2800 Plymouth Road 48105

Biocraft Laboratories, Inc. 18-01 River Road Fair Lawn NJ 07410

Sigma Chemical Company University of Massachusetts Medical Worcester Zurier, Robert B. M.D. Center 55 Lake Avenue MA 01655

Marinus Pharmaceuticals, Inc. 21 Business Park Drive Branford CT 06405 9314 East Broadway Sirion Therapeutics, Inc. Avenue Tampa FL 33619 Research Triangle Park Burroughs Wellcome Company 3030 Cornwallis Road P.O. Box 12700 NC 27709

1401 Eye Street, N.W. Fidia Pharmaceutical Corp. Suite 900 Washington DC 20005 Thousand Oaks CA Amgen One Amgen Center Drive Mail Stop 17-2-A 91320-1799 Memgen, LLC 7557 Rambler Road Dallas TX 75231

Ark Therapeutics Ltd. 1 Fitzroy Mews London UNITED KINGDOM

10650 Scripps Ranch San Diego MediGene, Inc. Blvd. Suite 230 CA 92131

ProcesScience, Inc (PSI) 117 Woodberry Lane Fayetteville NY 13066

New York NY Lipha Pharmaceuticals, Inc. 9 West 57th Street Suite 3825 10019-2701

Liposome Company, Inc. One Research Way Princeton NJ 08540

Teva Neurosciences, Inc. P. O. Box 1005 Horsham PA 19044-8005

TEVA Pharmaceuticals, USA 1090 Horsham Road North Wales PA 19454

5214 Maryland Way, Protherics, Inc. Suite 405 Brentwood TN 37027

Threshold Pharmaceuticals, Inc. 1300 Seaport Blvd. Redwood City CA 94063

Impulszentrum Graz - ProtAffin Biotechnologie AG West A-8020 Graz AUSTRIA

Chugai Pharmaceutical Co., Ltd. Subsidiary of Medicis Pharmaceutical Scottsdale AZ Ucyclyd Pharma, Inc Corporation 8125 N. Hayden Rd. 85258 South San Francisco CA Hyperion Therapeutics, Inc. 601 Gateway Blvd. Suite 200 94080 Kennedy Krieger Institute, Baltimore MD Moser, Hugo W. M.D. Johns Hopkins University 707 North Broadway 21205

Atlanta GA Sciele Pharma, Inc. Five Concourse Parkway Suite 1800 30328

GlycoMimetics, Inc. 101 Orchard Ridge Drive Gaithersburg MD 20878

Gradalis, Inc. 2545 Golden Bear Drive Carrollton TX 75006

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355-1307 The New York Hospital - 525 East 68th Street, Box New York NY Reidenberg, Marcus M. M.D. Cornell Medical Center 70 10021

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

DrugRecure Aps Scion DTU Boge alle 5, 1,tv DENMARK

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

North American Biologicals, Inc. 12280 Wilkins Avenue Rockville MD 20852

Valeant Pharmaceuticals International One Enterprise Way Aliso Viejo CA 92656

Novartis Pharmaceuticals East Hanover NJ 07936- Corporation 59 Route 10 1080 Corona CA Watson Laboratories, Inc. 311 Bonnie Circle PO Box 1900 91718-1900 Bristol-Myers Squibb Wallingford Pharmaceutical Research CT 06492- Institute 5 Research Parkway P.O. Box 5100 7660

Collgard Biopharmaceuticals Textile House, 2 Koifman Ltd. St. Tel-Aviv 68012 ISRAEL

Cadila Pharmaceuticals Limited, Gaithersburg Inc. 9801 Washingtonian Blvd Suite 220 MD 20878

16020 Swingley Ridge Chesterfield CPL, Inc. Road Suite 145 MO 63017

Orphan Europe Immeuble Le Guillaumet 92046 Paris La Defense FRANCE

70 avenue du General de 92056 Paris Orphan Europe Immeuble Le Guillaumet Gaulle, La Defense FRANCE University Of Massachusetts Medical Worcester Bonkovsky, Herbert L. M.D. Center 55 Lake Avenue North MA 01655

Chapel Hill Apex Bioscience, Inc. 109 Conner Drive ` NC 27514

Vectura Group, Inc. 1 Prospect West Wiltshire SN14 6FH UNITED KINGDOM

Ockham Biotech Limited Manor Farm 98 Swanwick Lane UNITED KINGDOM

Trillium Therapeutics, Inc. 96 Skyway Avenue M9W 4Y4 CANADA

Biotest Pharmaceuticals 5800 Park of Commerce Corporation Blvd., NW Boca Raton FL 33487

Biotest Pharmaceuticals 5800 Park of Commerce Corporation Blvd, NW Boca Raton FL 33487 Cubist Pharmaceuticals 65 Hayden Avnue Lexington MA 02421

Genetic Therapy, Inc. 938 Clopper Road Gaithersburg MD 20878

777 Old Saw Mill River EpiCept Corporation Road Tarrytown NY 10591

777 Old Saw Mill River EpiCept Corporation Road Tarrytown NY 10591 University of Texas Medical Branch at Route J-09, 700 The Galveston TX Anderson, Karl E., M.D. Galveston Strand 77550

Hemacare Corporation 4954 Van Nuys Boulevard Sherman Oaks CA 91403

9373 Towne Centre Dr., Vical Incorporated Suite 100 San Diego CA 92121

American BioScience, Inc. 2730 Wilshire Blvd. #110 Santa Monica CA 90403

Rhone-Poulenc Rorer Pharm. 500 Arcola Road Collegeville PA 19426

Gliknik, Inc. 801 W. Baltimore Street Baltimore MD 21201 Nventa San Diego StressGen Biotechnologies, Inc. Biopharmaceuticals CA 19426- is now Nventa Corporation 6055 Lusk Boulevard 2655

PDL BioPharma, Inc. 34801 Campus Drive Fremont CA 94555 Framingham MA 01701- Pharming/Genzyme LLC c/o Genzyme Corporation 1 Mountain Rd. 9322 Falk Center for Molecular Evanston IL Therapeutics 1801 Maple Avenue Suite 4300 60201

Medarex, Inc. 519 Route 173 West Bloomsbury NJ 08804 Genmab A/S Tolbodgade 33 DK-1253 Copenhagen K DENMARK

BioInvent International AB Solvegatan 41 SWEDEN

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355-1307

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355-1307

Genzyme Corporation One Kendall Square Cambridge MA 02139

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

Bone Therapeutics S.A. 8, rue Adrienne Bolland BELGIUM

Laboratoire francais du Fractionnement et des Biot 3 Avenue des Tropiques 91985 Courtaboeuf Cedex FRANCE

Biotest Diagnostics Corporation 66 Ford Road Denville NJ 07834

Bio Products Laboratory Dagger Lane Hertfordshire, WD6 3BX UNITED KINGDOM

Protein Therapeutics, Inc. 70 Calle Encanto Tucson AZ 85716

Protein Therapeutics, Inc. 70 Calle Encanto Tucson AZ 85716

Protein Therapeutics, Inc. 70 Calle Encanto Tuscon AZ 85716

Centocor, Inc. 244 Great Valley Parkway Malvern PA 19355 Centocor, Inc. 244 Great Valley Parkway Malvern PA 19355

Pharmalink AB P. O. Box 625 SWEDEN

5800 Park of Commerce NABI Blvd., NW Boca Raton FL 33487

5800 Park of Commerce NABI Blvd., N.W. Boca Raton FL 33487

5800 Park of Commerce NABI Blvd., NW Boca Raton FL 33487

Medarex, Inc. 519 Route 173 West Bloomsbury NJ 08804

Bristol-Myers Squibb Signature 91 Bldg/3SIG- Wallingford Pharmaceutical Research Insti 5 Research Parkway 3012 CT 06492

IRX Therapeutics, Inc. 140 West 57th Street New York City NY 10019

CuraGen Corporation 322 East Main Street Branford CT 06405

Kenta Biotech Limited Rehhagstrsase SWITZERLAND

Novartis Pharmaceuticals East Hanover NJ 07936- Corporation One Health Plaza 1080

Centocor, Inc. 200 Great Valley PArkway Malvern PA 19355-1307

Hoboken NJ Octapharma USA, Inc. 121 River Street 12th Floor 07030 Hoboken NJ Octapharma USA, Inc. 121 River Street 12th Floor 07030

Enobia Pharma, Inc. 2901 Rachel Street East Montreal, QC H1W 4A4 CANADA

GemVax A/S Drammensveien 100 0273 Oslo NORWAY MicroGeneSys, Inc. 1000 Research Parkway Meriden CT 06450

Centocor, Inc 200 Great Valley Parkway Malvern PA 19355-1307

MedImmune, Inc. 35 West Watkins Mill Rd. Gaithersburg MD 20878

MacroGenics, Inc. 1500 East Gude Drive Rockville MD 20850

Genzyme Corporation 500 Kendall Street Cambridge MA 02142 Charlestown Biotransplant, Inc. Building 75, 3rd. Ave. Charlestown Navy Yard MA 02129

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110-1199

Oklahoma OK Selexys Pharmaceuticals Corp. 800 Research Parkway Suite 338 73104

Biogen IdecInc. 3030 Callan Rd. San Diego CA 92121

Princeton NJ Teijin America, Inc. 600 Alexander Park Suite 304 08540

Morphotek, Inc. 210 Welsh Pool Road Exton PA 19341

Stromedix, Inc. One Canal Park Cambridge MA 02141 South San Francisco CA CoTherix 5000 Shoreline Court Suite 101 94080 Northfield IL Barbeau Pharma, Inc. 790 W. Frontage Road Suite 125 60093

Kullagatan 8-10, S-252 20 DuoCort AB Helsingborg SWEDEN Jazz Pharmaceuticals 3180 Porter Drive Palo Alto CA 94304

Elk Mountain Hall, Alan H., M.D. Mile 5.0 Pass Creek Road PO Box 24 WY 82324

UPM Pharmaceuticals, Inc. 6200 Seaforth Street Baltimore MD 21224

2751 Centerville Rd., Nexell Therapeutics Suite 210 Wilmington DE 19808 2751 Centerville Rd., Nexell Therapeutics, Inc. Suite 210 Wilmington DE 19808

Cambridge TransMolecular, Inc. 840 Memorial Drive Second Floor ResearchMA 02139 Triangle Park NC 27709- GlaxoSmithKline PO Box 13398 Five Moore Drive 3398

Westport CT Farmacon-IL, LLC 1720 Post Road East Suite 213 06880-5643

Jerini AG Invalidenstr, 130 10115 Berlin GERMANY

Jerini AG A subsidiary of Shire PLC Invalidenstr. 130 GERMANY Kalamazoo MI 49001- Pharmacia & Upjohn 7000 Portage Road Unit 0633-298-113 0199

Kalamazoo MI 49001- Pharmacia & Upjohn 7000 Portage Road Unit 0633-298-113 0199

Kalamazoo MI 49001- Pharmacia & Upjohn 7000 Portage Road Unit 0633-298-113 0199

Santhera Pharmaceuticals Limited Hammerstrasse 47 SWITZERLAND Santhera Pharaceuticals Limited Hammerstrasse 47 SWITZERLAND

Santhera Pharmaceuticals LLC Hammerstrasse 25 CH-4410 Liestal SWITZERLAND

225 East Deerpath, Suite NeoPharm, Inc. 250 Lake Forest IL 60045

ArmaGen Technologies, Inc. 914 Colorado Ave. Santa Monica CA 90401

Princeton NJ Bristol-Myers Squibb Company P.O. Box 4000 Mail Stop D12-02 08543-4000 Bristol-Myers Squibb Pharmaceutical Research Institute P.O. Box 4000 Princeton NJ 08543

Lake Forest NeoPharm, Inc. 150 Field Drive Suite 195 IL 60045

Vancouver, British Protox Therapeutics, Inc. 1210-885 West Georgia Columbia San Diego CANADA

Berlex Laboratories, Inc. 300 Fairfield Road Wayne NJ 07470

Berlex Laboratories, Inc. 300 Fairfield Road Wayne NJ 07470

Centocor, Inc. 244 Great Valley Parkway Malvern PA 19355

AmpliMed Corporation 4380 N. Campbell Ave. Tucson AZ 85718

AmpliMed Corporation 2321 Camino La Zorrela Tucson AZ 85718

AmpliMed Corporation 2321 Camino La Zorrela Tucson AZ 85718 AmpliMed Corporation 2321 Camino La Zorrela Tucson AZ 85718

San Diego Vital Therapies, Inc. 15222 Avenue of Science Suite C CA 92128

OMRIX Biopharmaceuticals, Plasma Fractionation Ltd. Institute Ramat Gan 52621 ISRAEL

ZLB Bioplasma AG Wankdorfstrasse 10 CH-3000 Bern 22 SWITZERLAND Westlake Village CA Baxter Healthcare Corporation, Baxter Bioscience 91362

Immuno Clinical Research Corp. 750 Lexington Avenue New York NY 10022

Immuno Clinical Research Corp. 155 East 56th Street New York NY 10022

750 Lexington Avenue, Immuno Clinical Research Corp. 19th Floor New York NY 10022 King of Prussia PA CSL Behring 1020 First Avenue P.O. Box 61501 19406-0901

Medical Research Laboratories Highland Heights KY International 2 Tesseneer Drive 41076

Medical Research Laboratories Highland Heights KY International 2 Tesseneer Drive 41076

Wallingford ALK Laboratories, Inc. Research Center 27 Village Lane CT 06492

Therion Biologics Corporation 76 Rogers Street Cambridge MA 02142

Centocor, Inc. 244 Great Valley Parkway Malvern PA 19355

Hybritech, Inc. 11095 Torreyanna Road San Diego CA 92196 RadioIsotope Therapy of America (RITA) Foundation 9701 Richmond Avenue Houston TX 77042

Malvern PA Centocor, Inc. 200 Great Valley Parkway 19355-1307

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355-1307

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355-1307

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355-1307 Houston TX Introgen Therapeutics, Inc. 2250 Holcombe Blvd 77030

Alpharetta GA Inhibitex, Inc. 8995 Westside Parkway Suite 150 30004

Princeton NJ EUSA Pharma 650 College Road East Suite 3100 08540

897 West Sixteenth Newport Pharmaceuticals Street Newport Beach CA 92663

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110-1199

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07119

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110-1199

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110-1199

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033 Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Research Triangle Park NC Glaxo Wellcome Inc. 5 Moore Drive 27709

Research Triangle Pk NC Burroughs Wellcome Company 3030 Cornwallis Road 27709

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

15049 San Pablo Avenue, Berlex Laboratories, Inc. P.O. Box 4099 Richmond CA 94804

EMD Serono, Inc. One Technology Place Rockland MA 02370 Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

EMD Serono, Inc. One Technology Place Rockland MA 02370 Foundation for Fatal Rare Diseases Herrengasse 21 Furstentum Liechtenstein GERMANY

InterMune, Inc. 3280 Bayshore Boulevard Brisbane CA 94005

South San Francisco CA Genentech, Inc.Center 1 DNA Wayfor Cancer Drud 94080-4990 Discovery and Clevland OH Ernest C.Borden Development 9500 Euclid Avenue 44195

Immunex Corporation 51 University Street Seattle WA 98101

Immunex Corporation 51 University Street Seattle WA 98101

Thousand Oaks CA 91320- Amgen, Inc. One Amgen Center Drive 1799

Thousand Oaks CA 91320- Amgen, Inc. One Amgen Center Drive 1799

Regeneron Pharmaceuticals, 777 Old Saw Mill River Inc. Road Tarrytown NY 10591

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110 Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Immunex Corporation 51 University Street Seattle WA 98101

Sandoz Pharmaceuticals Corp. 59 Route 10 East Hanover NJ 07936

Digestive Care, Inc. 1120 Win Drive Bethlehem PA 18017

GammaCan Ltd. 39 Jerusalem Street ISRAEL

Octapharma USA, Inc. 121 River Street Hoboken NJ 07030

Div. of Draxis Specialty DraxImage Pharmaceuticals, Inc. Kirkland, Quebec H9H 4J4 CANADA Molecular Insight Pharmaceuticals 160 Second street Cambridge MA 02142

Brogan Pharmaceuticals, LLC 312 Lacebark Street Schererville IN 46375 c/o Purdue Technology Crown Point Brogan Pharmaceuticals, Inc. 9800 Connecticut Drive Center IN 46307 University of Michigan Medical Center/1500 E. B1G412 /0028 University Ann Arbor MI David E. Kuhl, M.D. Med. Hospital 48109-0028

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

IBC Pharmaceuticals, L.L.C. 300 American Rd. Morris Plains NJ 07950

American Cyanamide Pearl River Lederle Laboratories Division Company 401 N. Middletown Road NY 10965 Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Peregrine Pharmaceuticals, Inc. 14282 Franklin Ave. Tustin CA 92780-7017

Eisai Medical Research, Inc. 55 Challengaer Road Ridgefield Park NJ 07660

Eisai Medical Research, Inc. 55 Challenger Road Rodgefield Park NJ 07660

Alpha Therapeutic Corporation 5555 Valley Boulevard Los Angeles CA 90032

Boston MA Perrine, Susan P., M.D. Boston University Cancer Research Center 02118

Amicus Therapeutics, Inc. 6 Cedar Brook Drive Cranbury NJ 08512

Fairfield Clinical Trials, LLC 200 Steep Hill Road Weston CT 06883

Academic Pharmaceuticals 21 N. Skokie Hwy Lake Bluff IL 60044

Wilmington Incyte Corporation Experimental Station Bldg E400/6430 DE 19880

Room 307, Koryo Ahyun-Dong, Mapo-Gu, Glovax Co., Ltd. Academytel, 437-3 Seoul 121-010

Pharmedic Company 28101 Ballard Road Lake Forest IL 60045 Pharmalucence, Inc. 10 DeAngelo Drive Bedford MA 01730

640 Memorial Drive, 3rd Transcend Therapeutics, Inc. Floor West Cambridge MA 02139

640 Memorial Drive, 3rd Transcend Therapeutics, Inc. Floor West Cambridge MA 02139 Corona CA Watson Laboratories, Inc. 311 Bonnie Circle P.O. Box 1900 91718-1900 Farmingdale Frontier Pharmaceutical, Inc. SUNY Farmingdale Conklin Hall NY 11735

VSL Pharmaceuticals, Inc. 800 S. Frederick Avenue Gaithersburg MD 20877

VSL Pharmaceuticals, Inc. 800 S. Frederick Ave. Gaithersburg MD 20877

Roxane Laboratories, Inc. P.O. Box 16532 Columbus OH 43216-6532

CepTor Corporation 200 International Circle Hunt Valley MD 21030

Vion Pharmaceuticals, Inc. Four Science Park New Haven CT 06511

Rare Disease Therapeutics, Inc. 2550 Meridian Blvd. Franklin TN 37067

University Of Pittsburgh Fromm, Gerhard M.D. School of Medicine Pittsburgh PA 15261

Osmotica Kft.

Osmotica Kft.

Osmotica Kft. The City College, City University Of NY Medical Convent Avenue at 138 New York NY Lev, Meir M.D. Sc Street 10031

Boston MA Brigham and Women's Hospital Channing Laboratory Dept. of Medicine 02115 Rush-Presbyterian-St. Luke's Medical Ctr., Dept. 1653 West Congress Chicago IL Williams, MD, James W. o Parkway 60612-3833

Celgene Corporation 86 Morris Avenue Summit NJ 07901

Celgene Corporation 86 Morris Avenue Summit NJ 07901

218 North Jefferson Chicago IL Errant Gene Therapeutics, LLC Street Suite 300 60661

Cephalon, Inc. 41 Moores Road Frazer PA 19355 Research Glaxo Wellcome Research and Triangle Park Development 5 Moore Drive PO Box 13398 NC 27709

Vienna VA CEL-SCI Corporation 8229 Boone Blvd. Suite 802 22182 Stony Brook NY 11794- Neuromuscular Adjuncts, Inc. S.U.N.Y. at Stony Brook H.S.C. T18-020 8181

Iolab Pharmaceuticals 500 Iolab Drive Claremont CA 94608 Sigma-Tau Pharmaceuticals, 9841 Washingtonian Gaithersburg Inc. Blvd. Suite 500 MD 20878

Sigma-Tau Pharmaceuticals, Gaithersburg Inc. 9841 Washingtonian Blvd Suite500 MD 20878

Sigma-Tau Pharmaceuticals, 9841 Washingtonian Gaithersburg Inc. Blvd. Suite 500 MD 20878

Sigma-Tau Pharmaceuticals, Gaithersburg Inc. 9841 Washingtonian Blvd Suite 500 MD 20878 Sigma-Tau Pharmaceuticals, Gaithersburg Inc. 9841 Washingtonian Blvd Suite 500 MD 20878

Solvay Pharmaceuticals, Inc. 901 Sawyer Road Marietta GA 30062 11535 Sorrento Valley Mpex Pharmaceuticals, Inc. Road San Diego CA 92121

Torrance CA Emmaus Medical, Inc. 3870 Del Amo Blvd Unit 507 90503-7701

Implicit Bioscience Pty Ltd P. O. Box 2072. Toowong Business Center AUSTRALIA

Barrier Therapeutics, Inc 600 College Road East Princeton NJ 08540

21823 30th Drive Seattle Genetics, Inc. Southeast Bothell WA 98021 21823 30th Drive Seattle Genetics, Inc. Southeast Bothell WA 98021

Protein Design Labs, Inc. 34801 Campus Drive Fremont CA 94555 Framingham MA 01701- Genzyme Corporation Metrowest Place P.O. Box 9322 9322

Fujisawa USA, Inc. 3 Parkway North Center Deerfield IL 60015

Callisto Pharmaceuticals, Inc. 420 Lexington Avenue New York NY 10170

Callisto Pharmaceuticals, Inc. 420 Lexington Avenue New York NY 10170

Aradigm Corporation 3929 Point Eden Way Hayward CA 94545

Aradigm Corporation 3929 Point Eden Way Hayward CA 94545

Monmouth Junction NJ Transave, Inc. 11 Deer Park Drive 08852-1923 Baylor College of Medicine, Dept. of Houston TX Vernon Knight, M.D. Molecular Phy One Baylor Plaza 77030

PARI Pharma GmbH Moosstrasse 3 GERMANY

Pol. Ind. Els Vinyets els GP-Pharm SA Fogars n 2, Quinti de Mediona Barcelona SPAIN

MedGenesis Therapeutix, Inc. 730-730 View Street Victoria, BC V8W 3Y7 CANADA

Endorex Corp. 900 North Shore Drive Lake Bluff IL 60044

Endorex Corp. 900 North Shore Drive Lake Bluff IL 60044

M.D. Anderson Cancer Houston TX The University of Texas Center Unit 038 77030

3293 Harrison Blvd., Suite Bio-Path, Inc. 230 Ogden UT 84403

Liposome Company, Inc. One Research Way Princeton NJ 08540

MedGenesis Therapeutix, Inc. 730-730-View Street Victoria, BC, V8W 3Y7 CANADA

Antigenics Incorporated 3 Forbes Road Lexington MA 02421

Oncothyreon Canada, Inc. 2011-94 St., NW Suite 200 CANADA

Oncothyreon Canada, Inc. 2011 - 94th Street NW 200 Edmonston, AB CANADA

201 Elliot Avenue Seattle WA Cell Therapeutics, Inc. West201 Suite 400 98119 Spectrum Pharmaceuticals, Inc. 157 Technology Drive Irvine CA 92618

R. W. Johnson Pharmaceutical Research Institute Route 202, P.O. Box 300 Raritan NJ 08869

Interneuron Pharmaceuticals, 99 Hayden Ave., Suite Inc. 200 Lexington MA 02421-7966

Tyson And Associates 12832 Chadron Avenue Hawthorne CA 90250

Evanston IL Nyxis Neurotherapies, Inc. 1801 Maple Avenue Suite 4300 60201

CMS Peptides Patent Holding Unit 2106, 21st Floor, Company Limited Island Place Tower 510 King's Rd North Point HONG KONG

Discovery Laboratories, Inc 2600 Kelly Road Warrington PA 18976

Discovery Laboratories, Inc. 2600 Kelly Road Warrington PA 18976

Discovery Laboratories, Inc. 2600 Kelly Road Warrington PA 18976

Discovery Laboratories, Inc. 2600 Kelly Road Warrington PA 18976

Discovery Laboratories, Inc. 2600 Kelly Road Warrington PA 18976

G.D. Searle & Company 4901 Searle Parkway Skokie IL 60077

Vivendy Therapeutics LTD Peter Merian -Strasse 45 SWITZERLAND

10220-L Old Columbia Celsion Corpora tion Road Columbia MD 21046

Actelion Pharmaceuticals Ltd. Gewerbestrasse 16 SWITZERLAND Round Lake IL 60073- Baxter Healthcare Corporation Route 120 & Wilson Road 0490

Gliknik, Inc. 801 W. Baltimore Street Baltimore MD 21201

Cambridge MA 02139- ARIAD Pharmaceuticals, Inc 26 Landsdowne Street 4234

ActivBiotics, Inc. 110 Hartwell Avenue Lexington MA 02421

Pharmaxis Ltd. 10 Rodborough Rd. NSW 2086 AUSTRALIA

Progen Industries Limited P. O. Box 28 Richlands 4077 AUSTRALIA

ViroPharma Inc. 730 Stockton Drive Exton PA 19341

Multidisciplinary Association for Psychedelic Studies, Inc. 3 Francis St. Belmont MA 02478

Glycomed, Inc 860 Atlantic Avenue Alameda CA 94501 San Diego GenStar Therapeutics CA 92121- Corporation 10865 Altman Row Suite 200 1113

Collipp, Platon J. M.D. 176 Memorial Drive Jesup GA 31545 Winston- Salem NC Targacept, Inc. 200 East First St. Suite 300 27101-4165

8720 Stony Point Insmed, Inc. Parkway Richmond VA 23235

Frazer PA Cephalon, Inc. 41 Moores Road P. O. Box 4011 19355

Yaupon Therapeutics, Inc. 259 Radnor Chester Road Radnor PA 19087 MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

ZaBeCor Pharmaceutical Company, LLC 821 Westview Street Philadelphia PA 19119

Mepha AG 4143 Dornach POSTFASH 137 SWITZERLAND

Mepha AG 4143 Dornach POSTFASH 137 SWITZERLAND Newport Hoag Memorial Hospital Hoag Cancer Center Cell Beach CA Presbyterian Biology Laboratory Building 41 92658

CancerVax Corporation 2110 Rutherford Road Carlsbad CA 92008

Bristol-Myers Squibb Research Wallingford Inst 5 Research Parkway P. O. Box 5100 CT 06492

Ribi ImmunoChem Research, Inc. 533 Old Corvallis Road Hamilton MT 59840

Neurim Pharmaceuticals, Ltd. 8 Hanechoshet St. Tel-Aviv ISRAEL

Oregon Health Sciences 3181 S.W. Sam Jackson Portland OR Sack, Robert, M.D. University Park Road 97201

CyDex Pharmaceuticals, Inc. 10513 W. 84th Terrace Lenexa KS 66214 Research Glaxo Wellcome Research and Triangle Park Development 5 Moore Drive PO Box 13398 NC 27709

Delcath Systems, Inc. Rockefeller Center New York NY 10020

New York NY Delcath Systems, Inc. Rockefeller Center 23rd Floor 10020 Cinergen, LLC 146 Medinah Drive Blue Bell PA 19422-3212

Cinergen 146 Medinah Drive Blue Bell PA 19422-3212

GlaxoSmithKline Pharmaceuticals P.O. Box 7929 Philadelphia PA 19101 Wilmington DE 19850- AstraZeneca Pharmaceuticals 1800 Concord Pike PO Box 15437 5437

Shire 725 Chesterbrook Blvd. Wayne PA 19087-5637

Tewksbury MA 01876- Asta Medica , Inc. 890 East St. 1496

Genopia USA, Inc. 90 Gold Street, 6N New York NY 10038

Philadelphia PA 19101- Wyeth-Ayerst Laboratories P.O. Box 8299 8299

Echo Therapeutics, Ltd. 10 Forge Parkway Franklin MA 02038

Therakos, Inc. 437 Creamery Way Exton PA 19431

Amylin Pharmaceuticals, Inc. 9360 Towne Centre Drive San Diego CA 92121

Amylin Pharmaceuticals, Inc. 9360 Towne Center Drive San Diego CA 92121

Formac Pharmaceuticals, NV Gaston Geenslaan 1 BELGIUM

Galderma Laboratories, Inc. P.O. Box 331329 Fort Worth TX 76163 Searle 4901 Searle Parkway Skokie IL 60077

Watford S.L.A. Pharma (UK) Ltd Elite House Leavesden WD25 7SA UNITED KINGDOM

Aton Pharma, Inc. 3150 Brunswick Place Lawrenceville NJ 08648

Tau Therapeutics, LLC 2988 Cove Trace Charlottesville VA 22911

Tau Therapeutics, LLC 2988 Cove Trace Charlottesville VA 22911

Cav-Con, Inc. 55 Knollwood Road Farmington CT 06032

Thrombotargets Corp. 2530 Meridian Parkway Durham NC 27713

Durham NC Thrombotargets Corp. 2530 Meridian Parkway Suite 3023 27713

8010 Arco Corporate Schwarz Biosciences, Inc. Drive Raleigh NC 27617

Immuno-Designed Molecules 9 Parker Irvine CA 92618-1605

HRA Pharma 15 , rue Beranger 75003 Paris FRANCE

Corcept Therapeutics, Inc. 149 Commonwealth Drive Menlo Park CA 94025

Actelion Pharmaceuticals Ltd Innovation Centre CH-4123, Allschwil SWITZERLAND

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950 Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

ExperGen Drug Development Hernalser Haupstrasse GmbH 24/16 AUSTRIA

Dover DE Paladin Labs (USA), Inc. 160 Greentree Drive Suite 101 19904

Division of American Pearl River Lederle Laboratories Division Cyanamid Company 401 N. Middletown Road NY 10965 Autoimmunity Research Autoimmunity Research, Foundation Inc. Thousand Oaks CA 91360

Gynuity Health Projects, LLC 15 East 26th Street New York NY 10010 San Antonio TX 78229- ILEX Oncology, Inc. 4545 Horizon Hill Blvd. 2263

Biopharmaceutics, Inc. 990 Station Road Bellport NY 11713

Biopharmaceutics, Inc. 990 Station Road Bellport NY 11713

Mobius Therapeutics, Inc. 743 Spirit 40 Park Drive Chesterfield MO 63005

3100 Airway Avenue, IOP Inc. Suite 106 Costa Mesa CA 92626

Immunomedics, Inc. 300 American Rd. Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033 Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Ackerstein Towers, Bldg Ester Neurosciences Ltd. B, 10th Floor 11 HaManoflm St. ISRAEL

IDEC Pharmaceuticals Corporation 3030 Callan Road San Diego CA 92121

IDEC Pharmaceuticals Corporation 11011 Torreyana Road San Diego CA 92121

Centocor, Inc. 244 Great Valley Parkway Malvern PA 19355 Research Triangle Park United Therapeutics Corporation PO Box 14186 One Park Drive NC 27709

2825 Santa Monica Blvd., VivoRx Autoimmune, Inc. Suite 200 Santa Monica CA 90404

Protein Design Labs, Inc. 2375 Garcia Avenue Mountain View CA 94043

Protein Design Labs, Inc. 2375 Garcia Avenue Mountain View CA 94043

Protein Design Labs, Inc. 34801 Campus Dr. Fremont CA 94555

ViRexx Medical Corporation 8223 Roper Road Edmonton CANADA

Pfizer, Inc. 235 East 42nd Street New York NY 10017 Research Triangle Park Glaxo Wellcome Inc. 5 Moore Drive PO Box 13398 NC 27709

Pharmacyclics, Inc. 999 East Arques Avenue Sunnyvale CA 94085-4521 4330 La Jolla Village San Diego FeRx Incorporated Drive Suite #250 CA 92122

North American Biologicals, Inc. 12280 Wilkins Avenue Rockville MD 20852

North American Biologicals, Inc. 12280 Wilkins Avenue Rockville MD 20852

Novartis Pharmaceuticals East Hanover NJ 07936- Corporation One Health Plaza 1080

Astra Pharmaceuticals, L.P. 725 Chesterbrook Blvd. Wayne PA 19087-5677

Tustin CA Peregrine Pharmaceuticals, Inc. 14272 Franklin Ave. Suite 100 92780

London W5 Antisoma plc West Africa House Hanger Lane Ealing 3QR UNITED KINGDOM

Epeius Biotechnologies Corporation 475 Huntington Drive San Marino CA 91108

Epeius Biotechnologies Corporation 475 Huntington Drive San Marino CA 91108

Epeius Biotechnologies 345 Pioneer Drive, Corporation 1803W Glendale CA 91203

Statens Seruminstitut 5 Artillerivej DK-2300 Copenhagen S SWEDEN

Hoffman-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

AutoImmune, Inc. 128 Spring Street Lexington MA 02173

Columbus OH Abbott Nutrition Abbott Laboratories 625 Cleveland Ave. 43215-1724

Orexo AB Box 303 Virdings alle 32 A SWEDEN AB Science 3, avenue George V FRANCE

Bridgewater Aegerion Pharmaceuticals, Inc. Center Pointe IV Suite 304 NJ 08807

Thousand Oaks CA 91320- Amgen, Inc. One Amgen Center Drive 1799 Cambridge MA 02139- Vertex Pharmaceuticals, Inc. 130 Waverly St. 4242

MethylGene 7220 Frederick Banting St. Laurant CANADA

MethylGene 7220 Frederick Banting Quebec H4S 2A1 CANADA

4215 Sorrento Valley Ambit Biosciences Corporation Boulevard San Diego CA 92121

AB Science 3, avenue George V FRANCE Abbott Park Pharmaceuticals Products IL 60064- Abbott Laboratories Division D-491, AP30-1E 6157

San Diego CytRx Corporation 3030 Bunker Hill Street Suite 101 CA 92109 Abbott Park Global Pharmaceuticals IL 60064- Abbott Laboratories Research & Development 200 Abbott Park Road 6157 Abbott Park Global Pharmaceuticals IL 60064- Abbott Laboratories Research & Development 200 Abbott Park Road 6157

Coley Pharmaceuticals Group, Wellesley MA Inc. 93 Worcester Street Suite 101 02481

New London Pfizer, Inc. 50 Pequot Avenue 6025-A3106 CT 06320

NeuroSearch A/S 93 Pederstrupvej DK-2750 Ballerup DENMARK Biotest Pharmaceuticals 5800 Park of Commerce Corporation Blvd., NW Boca Raton FL 33487

Cook Pharma 109 Graylyn Drive Chapel Hill NC 27516

Galephar Pharmaceutical Road 198, No. 100 km. Juncos Research, Inc. University14.7 of Texas Juncos Industrial Park 00777-3873 PUERTO RICO Southwestern Medical Dallas TX William M. Lee, MD, FACP Center at 5323 Harry Hines Blvd 75390-9151

Monmouth Junction NJ ExSAR Corporation 11 Deer Park Drive 08852

Los Angeles Medco Research, Inc. 8455 Beverly Blvd. Suite 308 CA 90048

3560 Pennsylvania NAPA of the Bahamas Avenue, Suite 7 Dubuque IA 52002

Pharmaceutical Products Abbott Park Abbott Laboratories Division 200 Abbott Park Road IL 60064

9610 Medical Center Sequella, Inc. Drive Rockville MD 20850

Amarillo Biosciences, Inc. 4134 Business Park Drive Amarillo TX 79110

Amarillo Biosciences, Inc. 4134 Business Park Drive Amarillo TX 79110

Amarillo Biosciences, Inc. 4134 Business Park Drive Amarillo TX 79110

Copiaque NY WATSON Laboratories, Inc. 33 Ralph Avenue P.O. Box 30 11726-0030

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355 6560 Fannin, Scurlock Ericsson, Arthur Dale, M.D. Tower, Suite 720 Houston TX 77303 400 Rella Boulevard, Ferring Laboratories, Inc. Suite 201 Suffern NY 10901

MetroHealth Medical Cleveland OH Fleischmann, Jonathan M.D. Center 3395 Scranton Road 44109

Valley Fever Center for Excellence (1-111 INF) University of Arizona Tucson AZ 85723

Novartis Pharmaeuticals East Hanover NJ 07936- Corporation One Health Plaza 1080

Mississauga, Ontario L4W YM Biosciences Inc. 5045 Orbitor Drive 4Y4 CANADA

Xechem International, Inc. 379 Thornall Street Edison NJ 08837

6200 Courtney Campbell Tampa FL Romark Laboratories, L.C. Causeway Suite 880 33607

Swedish Orphan AB Kungsgatan 37, 7th Floor SE-111 56 SWEDEN

INO Therapeutics 6 Route 173 Clinton NJ 08809 22705 Savi Ranch Yorba Linda CA 92887- SensorMedics Corporation Parkway 4645

INO Therapeutics 6 Route 173 Clinton NJ 08809

INO Therapeutics, Inc. 54 Old Highway 22 Clinton NJ 08809 Thomas Jefferson Philadelphia University and Wills 834 Walnut Street, Suite PA 19107- Thomas, MD, Jeffrey Evan Neurosensory 650 5102

Synta Pharmaceuticals Corporation 45 Hartwell Ave. Lexington MA 02421

10646 Science Center San Diego Pfizer, Inc. La Jolla Laboratories Drive CA 92121 San Carlos Nuvelo, Inc. Inc. 201 Industrial Road Suite 310 CA 94070-

Antisoma Research Ltd. Hanger Lane Ealing UNITED KINGDOM

Antisoma Research Ltd. Hanger Lane Ealing, London UNITED KINGDOM Novazyme Pharmaceuticals, City OK Inc. 800 Research Parkway Suite 200 73104

Gemin X, Inc. 5 Great Valley Parkway Malvern PA 19355

Gemin X, Inc. 5 Great Valley Parkway Malvern PA 19355

Gemin X Pharmaceuticals US, Malvern PA Inc. 400 Chesterfield Pkwy. Suite 100 19355

Berkeley Heights NJ Genta Inc. Two Connell Drive 07922

Berkeley Heights NJ Genta, Inc. Two Connell Drive 07922

Berkeley Heights NJ Genta, Inc, Two Connell Drive 07922

Berkeley Heights NJ Genta, Inc. Two Connell Drive 07922

GlaxoSmithKline One Franklin Plaza Phildelphia PA 19101

Implicit Bioscience Pty Ltd P. O. Box 2072 Toowong Business Center AUSTRALIA

Omex International, Inc. 6001 Savoy, Suite 110 Houston TX 77036

ChemGenex Pharmaceuticals, Inc. 3715 Haven Avenue Menlo Park CA 94025 ChemGenex Pharmaceuticals, Inc. 3715 Haven Avenue Menlo Park CA 94025

Research Triangle 4364 South Alston Pharmaceuticals Avenue Durham NC 27713

Pronova Biocare, AS PO Box 420 1327 Lysaker NORWAY Fresenius Kabi Deutschland GmbH Daimlerstrasse 16 GERMANY

Santhera Pharmaceuticals Limited Hammerstrasse 47 SWITZERLAND

Antigenics, Inc. 3 Forbes Road Lexington MA 02421

Cytogen Corporation 600 College Road East Princeton NJ 08540

863 Mitten Road, Suite TRF Technologies, Inc. 101 Burlingame CA 94010

6040 N. Cutter Circle, Oxis International, Inc. Suite 317 Portland OR 97217-3935

Debio Pharm S.A. Rue des Terreaux 17 CH-1000 SWITZERLAND

OxThera, Inc. 13709 Progress Blvd. #17 Alachua FL 32615

Bio-Technology General Corp. 70 Wood Avenue, South Iselin NJ 08830

Bio-Technology General Corp. 70 Wood Avenue, South Iselin NJ 08830

One Tower Center Savient Pharmaceuticals, Inc. Boulevard, 12th floor East Brunswick NJ 08816

One Tower Center Bio-Technology General Corp. Boulevard, 12 th floor East Brunswick NJ 08816 Bio-Technology General Corp. 70 Wood Avenue South Iselin NJ 08830

DuPont Merck Pharmaceutical Company P.O. Box 80027 Wilmington DE 19880

Cardiome Pharma Corp. 3650 Westbrook Mall Vancouver, B.C. CANADA

Durham NC Inspire Pharmaceuticals, Inc. 4222 Emperor Blvd. Suite 470 27703

4222 Emperor Blvd., Inspire Pharmaceuticals, Inc. Suite 470 Durham NC 27703

MediGene AG Lochhamer Str. 11 GERMANY

Baker Norton Pharmaceuticals, Inc. 4400 Biscayne Boulevard Miami FL 33137

Brentwood Protherics, Inc. 5214 Maryland Way Suite 405 TN 37027

Protherics, Inc. 5214 Maryland Way Brentwood TN 37027

Oasmia Pharmaceutical AB Vallongatan Uppsala SWEDEN

Immtech Pharmaceuticals, Inc. 150 Fairway Drive Vernon Hills IL 60061

Immtech Pharmaceuticsl, Inc. 150 Fairway Drive Vernon Hills IL 60061 Vernon Hills Immtech Pharmaceuticals, Inc. 150 Fairway Drive Suite 150 IL 60061

One First Avenue, Parris Ziopharm Oncology, Inc. Building 34 Boston MA 02129

Novartis Pharmaceuticals East Hanover NJ 07936- Corporation One Health Plaza 1080 Marlyn Nutraceuticals, Inc. 14851 N. Scottsdale Rd. Scottsdale AZ 85254

NPS Pharmaceuticals, Inc. 300 Interpace Parkway Parsippany NJ 07054 Ft. Detrick Office of the Surgeon General Department of the Army 1430 Veteran's Drive MD 21702

MedImmune, Inc. 35 West Watkins Mill Rd. Gaithersburg MD 20878

2420 Castillo Street, Suite Ear Foundation 100 Santa Barbara CA 93105

Novartis Pharmaceutical East Hanover NJ 07936- Corporation One Health Plaza 1080

National Institute of Mental Bethesda MD Health, NIH 49 Convent Dr. MSC4405 Bldg. 49, Room B1EE16 20892-4405

Hoffman-La Roche Inc. 340 Kingsland St. Nutley NJ 07110-1199

Hoffman-La Roche Inc. 340 Kingsland St. Nutley NJ 07110-1199

Schering-Plough Corporation 2000 Galloping Hill Road Kenilworth NJ 07933-0530

Chiron Corporation 4560 Horton Street Emeryville CA 94608

San Diego Polaris Pharmaceuticals, Inc. A Polaris Group Company Suite 106 CA 92121

San Diego Polaris Pharmaceuticals, Inc. A Polaris Group Company 6370 Nancy Ridge Drive CA 92121

Thousand Oaks CA 91320- Amgen, Inc. One Amgen Center Dr. 1789

BioCryst Pharmaceuticals, Inc. 2190 Parkway Lake Drive Birmingham AL 35244 King of Prussia PA Aventis Behring L.L.C. 1020 First Avenue PO Box 61501 19406-0901 755 Jefferson Rd., P.O. Fisons Corporation Box 1710 Rochester NY 14603 Heyl Chemisch- Pharmazeutische Fabrik GMBH Fedderal of Republic of & Co. KG Goerzallee 253 Germany GERMANY

TRF Pharma, Inc. 863 Mitten Road Burlingame CA 94010

Dublin CA SuperGen, Inc. 4140 Dublin Blvd. Suite 200 94568

Dublin CA SuperGen, Inc. 4140 Dublin Blvd. Suite 200 94568

Dublin CA SuperGen, Inc. 4140 Dublin Blvd. Suite 200 94568

Avenida Carlos III el Digna Biotech, S.L. Noble Pamplona (Navarra) SPAIN

Avenida Carlos III el Digna Biotech, S.L. Noble, 36, 1 Dcha. 31003 SPAIN

Ardana Bioscience Ltd. 38 Melville Street Scotland UNITED KINGDOM

Alliance Pharmaceutical Corp. 3040 Science Park Road San Diego CA 92191

Scios Nova, Inc. 2450 Bayshore Parkway Mountain View CA 94043

Cincinnati Children's Cincinnati OH Sallee, Floyd R. M.D., Ph.D. Hospital Medical Center 3333 Burnet Ave. 45229-3039

Elan Drug Delivery, Inc. 1300 Gould Dr. Gainesville GA 30504

Biomarin Pharmaceutical 105 Digital Drive Novato CA 94949 Elan Drug Delivery, Inc. 1300 Gould Dr. Gainesville GA 30504

Unit 3, Hill Farm Industrial S.L.A. Pharma Estate Leavesden, Watford UNITED KINGDOM

Port Jefferson Business 200 Wilson Street, Building Port Jefferson Medea Research Laboratories Center D-6 NY 11776

The Cure Our Children Pacific Palisades CA Foundation 1730 Michael Lane 90272-2037

Isis Pharmaceuticals, Inc. 1896 Rutherford Road Carlsbad CA 92008

Poniard Pharmaceuticals 300 Elliott Avenue West Seattle WA 98119

UCB Pharma, Inc. 1950 Lake Park Drive Smyrna GA 30080 Research Triangle Park Burroughs Wellcome Company 3030 Cornwallis Road P.O. Box 12700 NC 27709

Copernicus Therapeutics, Inc. 11000 Cedar Avenue Cleveland OH 44106

Talecris Biotherapeutics, Inc. 8368 US 70 West Clayton NC 27520

BTG International, Ltd 10 Fleet Place London EC4M 7SB UNITED KINGDOM

BTG International Ltd 10 Fleet Place London EC4M 7SB Cambridge UNITED KINGDOM MA 02139- PharmaMar USA, Inc University Park at M.I.T. The Richards Building 64 Cambridge4170 MA 02139- PharmaMar USA, Inc. University Park at M.I.T. The Rishards Building 4170

CytRx Corporation 154 Technology Parkway Norcross GA 30092 SynthRx Corporation 4606 Willow Bellaire TX 77401

CytRx Corporation 154 Technology Parkway Norcross GA 30092

CytRx Corporation 154 Technology Parkway Norcross GA 30092

Philadelphia Hemispherx Biopharma, Inc. One Penn Center 1617 JFK Boulevard PA 19103

Philadelphia Hemispherx Biopharma, Inc. One Penn Center 1617 JFK Boulevard PA 19103

Philadelphia Hemispherx Biopharma, Inc. One Penn Center 1617 JFK Boulevard PA 19103 Philadelphia Hemispherx Biopharma, Inc. One Penn Center 1617 JFK Boulevard PA 19103

One Tower Center Savient Pharmaceuticals, Inc. Boulevard, 14th floor East Brunswick NJ 08816

Paramus NJ EnzymeRx, LLC 17 Arcadian Avenue Suite 104 07652

Paramus NJ EnzymeRx, LLC 17 Arcadian Avenue Suite 104 07652

Paramus NJ EnzymeRx, LLC 17 Arcadian Avenue Suite 104 07652

3202 Cleveland Avenue Oncovir N.W. Washington DC 20008

Washington DC 20008- Oncovir 3203 Cleveland Ave., NW 3450

Washington DC 20008- Oncovir 3203 Cleveland Ave., NW 3450 Washington DC 20008- Oncovir 3203 Cleveland Ave., NW 3450

Capmed USA P.O. Box 14 Bryn Mawr PA 19010

Polyphenon E International, Inc. 655 Third Avenue New York NY 10017

11622 El Camino Real Polynoma LLC #100 San Diego CA 92130 Cambridge MA 02139- Diacrin/Genzyme LLC One Kendall Square 1562 Cambridge MA 02139- Diacrin/Genzyme LLC One Kendall Square 1562

Cambridge MA 02129- Diacrin/Genzyme LLC One Kendall Square 1562

Cambridge MA 02139- Diacrin/Genzyme LLC One Kendall Square 1562

50 Division Street, Suite Somerville NJ Titan Pharmaceuticals, Inc. Post Office Plaza 503 08876

Axcan Scandipharm Inc. 22 Inverness Parkway Birmingham AL 35242

401 North Middletown Pearl River QLT Phototherapeutics, Inc. Lederle Laboratories Road NY 10965

Boehringer Ingelheim Ridgefield CT Pharmaceuticals, Inc. 900 Ridgebury Road PO Box 368 06877

Boehringer Ingelheim Ridgefield CT Pharmaceuticals, Inc. 900 Ridgebury Road PO Box 368 06877

Schering-Plough Corporation 2000 Galloping Hill Road Kenilwortoh NJ 07033

Willen Drug Company

Framework Therapeutics, LLC 1564 33rd Street, NW Washington DC 20007 The Vaccine Company P. O. Box 93921 Carmel CA 93921

The Vaccine Company P. O. Box 93921 Carmel CA 93921

The Vaccine Company P. O. Box 93921 Carmel CA 93921

Pharmos 2 Innovation Drive Alachua FL 32615

Pharmos 2 Innovation Drive Alachua FL 32615

Pharmos 2 Innovation Drive Alachua FL 32615

Pharmos 2 Innovation Drive Alachua FL 32615

Allos Therapeutics, Inc. 11080 CirclePoint Road Westminster CO 80020 11080 Circle Point Road, Allos Therapeutics, Inc. Suite 200 Westminister CO 80020

Westminster Allos Therapeutics, Inc. 11080 CirclePoint Road Suite 200 CO 80020

Boehringer-Ingelheim Pharmaceuticals, Inc. 900 Ridgebury Road Ridgefield CT 06877

1 Kendall Square, Bldg. Cambridge Neuroscience, Inc. 700 Cambridge MA 02139

EM Pharmaceuticals, Inc.

Pharmacia Inc. P.O. Box 16529 Columbus OH 43216-6529

Sanofi Winthrop, Inc. 90 Park Avenue New York NY 10016 Sigma-Tau Pharmaceuticals, Gaithersburg Inc. 9841 Washingtonian Blvd Suite 500 MD 20878

Watson Laboratories, Inc. 311 Bonnie Circle Corona CA 91720

8500 Hidden River Tampa FL Bausch & Lomb Pharmaceuticals Division Parkway 33637

Pierre Fabre Dermatologie Les-Cauquillous FRANCE

Research & Development 2-5-1 Atago, Minato-ku, LTT Baio-Pharma Co., Ltd Division Tokyo JAPAN

Alpha Therapeutic Corporation 5555 Valley Boulevard Los Angeles CA 90032 La Jolla CA Biophysica, Inc. 2159 Avenida de la Playa Suite B 92037

750 Lexington Avenue, Immuno Clinical Research Corp. 19th Floor New York NY 10022

750 Lexington Avenue, Immuno Clinical Research Corp. 19th Floor New York NY 10022

UCB Pharma, Inc. 1950 Lake Park Drive Smyrna GA 30080

Abbott Laboratories 200 Abbott Park Road Abbott Park IL

Scios Nova, Inc. 2450 Bayshore Parkway Mountain View CA 94043

ImmuneWorks, Inc. 351 West 10th Street Indianapolis IN 46202

Needham MA Able Laboratories, Inc. 200 Highland Avenue Suite 30 02494

AutoImmune, Inc. 128 Spring Street Lexington MA 02421 Flemington Cellular Sciences, Inc 84 park Avenue P.O. Box 968 NJ 08822

Lyphomed, Inc.

Zydus Pharmaceuticals, Inc. 210 Carnegie Center Princeton NJ 08540

Malvern PA Ascenta Therapeutics, Inc. 101 Lindenwood Drive Suite 405 19355

Seaside Therapeutics, Inc. 840 Memorial Drive Cambridge MA 02139

Applied Genetic Technologies Alachua FL Corp. 11801 Research Drive Suite D 32615

Children's Hospital of Pittsburgh University of Pittsburgh Pittsburgh PA 15213

Alfacell Corporation 225 Belleville Ave. Bloomfield NJ 07003

OncoImmune, Inc. 4532 Benderton Court Columbus OH 43220 Cambridge MA 02139- ARIAD Pharmaceuticals, Incx. 26 Landsdowne Street 4234

Human Genome Sciences, Inc. 14200 Shady Grove Road Rockville MD 20850

Applied Genetic Technologies Alachua FL Corp. 12085 Research Drive Suite 110 32615

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

Novartis Pharmaceutical East Hanover Corporation Oncology Business Unit One Health Plaza NJ 07986 Novartis Pharmaceutical East Hanover Corporation Oncology Business Unit One Health Plaza NJ 07936

Xoma (US) LLC 2910 Seventh Street Berkeley CA 94710

Pine Brook Elusys Therapeutics, Inc. 25 Riverside Drive P.O. Box 102 NJ 07058

PharmaOrigin ApS Scion DTU Boge alle 5, 1.tv DENMARK

Alseres Pharmaceuticals, Inc. 85 Main Street Hopkinton MA 01748

Westlake Village CA Baxter Healthcare Corporation Baxter Bioscience 91362

Westlake Village CA Baxter Healthcare Corporation Baxter Bioscience 91362

Rue des Professeurs Henogen S.A. Jenner et Brachet, 12 B-6041-Gosselies BELGIUM

Annapolis MD PharmAthene, Inc. One Park Place Suite 450 21401

Viventia Biotech, Inc. 10 Four Seasons Place Toronto ON M9B 6H7 CANADA

NPS Allelix Corp. 6850 Goreway Dr. Ontario L4V 1V7 CANADA

Arriva Pharmaceuticals, Inc. 1010 Atlantic Avenue Alameda CA 94501

Arriva Pharmaceuticals, Inc. 2020 Challenger Drive Alameda CA 94501 PPL Therapeutics (Scotland) Limited Roslin, Edinburgh EH259PP Scotland UNITED KINGDOM

Arriva Pharmaceuticals, Inc. 1010 Atlantic Avenue Alameda CA 94501

Merrimack Pharmaceuticals, Inc. 101 Binney Street Cambridge MA 02142 Zymenex A/S Roskildevej 12 C DENMARK

Philadelphia PA 19101- Wyeth Pharmaceuticals, Inc. P. O. Box 8299 8299 15 Pleasant St. Connector, Framingham AT III LLC c/o Genzyme Corporation P.O. Box 9322 MA 01701

Shire Human Genetic Therapies 700 Main Street Cambridge MA 02139

Pharming Technologies B.V. Archimedesweg 4 NETHERLANDS

Pharming Technologies B.V. Archimedesweg 4 NETHERLANDS

Pharming N.V. Cipalstreet 3 B-2440 Geel BELGIUM

Pharming N.V. Cipalstreet 3 B-2440 Geel BELGIUM 460 Point San Bruno South San Francisco CA Genentech, Inc. Boulevard 94080

CC10 Sweden AB Kornhamnstorg 53 Box 2077 SWEDEN

A Subsidiary of Biogen Syntonix Pharmaceuticals Idec Waltham MA 02451

9640 Medical Center EntreMed, Inc. Drive Rockville MD 20850

9640 Medical Center EntreMed, Inc. Drive Rockville MD 20850

Pharming Technologies B.V. Archimedesweg 4 NETHERLANDS

CuraGen Corporation 322 East Main Street Branford CT 06405

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142 Biogen, Inc. 14 Cambridge Center Cambridge MA 02124

Nora Therapeutics, Inc. 2400 Boston Street Baltimore MD 21224

Oklahoma Novazyme Pharmaceuticals, City OK Inc. 800 Research Parkway Suite 200 73104

SymbioTec GmbH Sciene Park Saar 1 Saarbruecken GERMANY

Kalamazoo MI 49001- Pharmacia & Upjohn 7000 Portage Road 0199

Kalamazoo MI 49001- Pharmacia & Upjohn 7000 Portage Road 0199

GroPep Pty Ltd. Gate 11, Victoria Dr. Adelaide SA 5000 AUSTRALIA

Frazer PA Cephalon, Inc. 41 Moores Road P. O. Box 4011 19355

8720 Stony Point Glen Allen VA Insmed, Inc. Parkway Suite 200 23235-

Genetics Institute, Inc. 87 CambridgePark Drive Cambridge MA 02140

1201 Eastlake Avenue Zymo Genetics, Inc East Seattle WA 98102

Thousand Oaks CA 91320- Amgen Inc. One Amgen Center Dr. 1799

Subsidiary of Kentucky Owensboro Lysosomal Acid Lipase, LLC BioProcessing, LLC 3700 Airpark Drive KY 42301

Unit 14, Bridgecourt ThromboGenics Ltd Office Park Dublin IRELAND Adienne S.r.1. 24128 Bergamo 64/B Boseta Street ITALY

24128 Bergamo, 64/B Adienne S.r.1. Broseta Street ITALY

East Hanover NJ 07936- Novartis Pharmaceuticals Corp. One Health Plaza 1080 UNITED KINGDOM South San Francisco CA Genentech, Inc. 1 DNA Way 94080

Dyax Corporation 300 Technology Square Cambridge MA 02139

Shirley NY Luitpold Pharmaceuticals, Inc. P. O. Box 9001 One Luitpold Drive 11967

Zymenex A/S Roskildevej 12C 3400 Hillerod DENMARK

ZymenexA/S Roskildevej 12C 3400 Hillerod DENMARK

Centro de Empresas de ProRetina Therapeutics, S.L. Pozuelo 28224 Pozuelo de Alarcon SPAIN

3400 West Bayshore Connetics Corporation Road Palo Alto CA 94303

12 Rue Jean Antoine de Fovea Pharmaceuticals Baif Paris FRANCE South San Francisco CA Genentech, Inc. 1 DNA Way 94080-4990

Proteon Therapeutics, Inc. 200 West Street Waltham MA 02451 USC Department of David T. Woodley, MD and Mei Dermatology, Cancer Los Angeles Chen, MD Research Lab 1303 North Mission Road CA 90033

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142 Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Thousand Oaks CA 91320- Amgen, Inc. One Amgen Center Dr. 1799

PEPGEN Corporation 1301 Harbor Bay Parkway Alameda CA 94502

Ipsen Limited 190 Bath Road Berkshire S11 3XE UNITED KINGDOM

San Bruno CA 94066- Y's Therapeutics, Inc. 1111 Bayhill Drive Suite 405 3002

Y's Therapeutics, Inc. 866 Malcolm Road Burlingame CA 94010

Genetic Therapy, Inc. 938 Clopper Road Gaithersburg MD 20878

Amgen, Inc. 3200 Walnut Street Boulder CO 80301

Amgen Inc. 3200 Walnut Street Boulder CO 80301

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

460 Point San Bruno South San Francisco CA Genentech, Inc. Boulevard 94080

Artielle ImmunoTherapeutics, 9020 SW Washington Tigard, OR Inc. Square Road Suite 450 97223-4332 Aerovance, Inc. 2929 Seventh Street Berkeley CA 94710

Sanofi-Synthelabo Research 9 Great Valley Parkway Malvern PA 19355 Telluride Pharmaceutical Corporation 146 Flanders Drive Hillsborough NJ 08876

AstraZeneca LP 725 Chesterbrook Blvd. Wayne PA 19087-5677

Dompe s.p.a. Via Campo di Pile 67100 - L'Aquila ITALY

Questcor Pharmaceuticals, Inc. 3260 Whipple Road Union City CA 94587-1217 Bldg 10/Rm 2N236 - Bethesda MD NIH/NIDCR DASS/CC 10 Convent Drive 20892

Malvern PA Ception Therapeutics, Inc. 101 Lindenwood Drive Suite 400, Valleybrook III 19335

35 West Watkins Mill MedImmune, Inc. Road Gaithersburg MD 20878

Infinity Pharmaceuticals, Inc. 780 Memorial Drive Cambridge MA 02139 AstraZeneca Pharmaceuticals DE 19803- LP P. O. Box 8355 1800 Concord Pike 8355

Cephalon, Inc. 41 Moores Road Frazer PA 19355 Overland 9200 Indian Creek Park KS AVAX technologies, Inc. Parkway Building 9, Suite 200 66210 Framingham MA 01701- Genzyme Corporation One Mountain Road P.O. Box 9322 9322 Abbott Park Abbott Laboratories, IL 60064- Abbott Dept. 389, Bldg. J-45 200 Abbott Park Rd. 6135 Abbott Park Abbott Laboratories, IL 60064- Abbott Dept. 389, Bldg. J-45 200 Abbott Park Rd. 6133 1100 Olive Way, Suite Targeted Genetics Corporation 100 Seattle WA 98101

Insmed Inc. 4851 Lake Brooke Drive Glen Allen VA 23060

ThromboGenics Inc. Unit 14 Walkinstown Avenue Dublin 12 IRELAND

Valeant Pharmaceuticals International 3300 Hyland Avenue Costa Mesa CA 92626

ImmunoGen, Inc. 148 Sidney Street Cambridge MA 02139

ImmunoGen, Inc. 148 Sidney Street Cambridge MA 02139

ImmunoGen, Inc. 148 Sidney Street Cambridge MA 02139

ImmunoGen, Inc. 148 Sidney Street Cambridge MA 02139

ImmunoGen, Inc. 148 Sidney Street Cambridge MA 02139

ImmunoGen, Inc. 148 Sidney Street Cambridge MA 02139

Pfizer, Inc. 235 East 42nd Street New York NY 10017

Seattle WA PathoGenesis Corporation 201 Elliott Avenue West Suite 150 Kansas98119 City MO 64134- Hoechst Marion Roussel, Inc. P.O. Box 9627 Mail Station: H3-M2516 0627 Kansas City MO 64134- Hoechst Marion Roussel , Inc. P.O. Box 9627 Mail Station: H3-M2516 0627 1700 Perimeter Park Salix Pharmaceuticals, Inc. Drive Morrisville NC 27560

Sparta Pharmaceuticals, Inc. 111 Rock Road Horsham PA 19044-2310 Collegeville Rhone-Poulenc Rorer PA 19426- Pharmaceuticals, Inc. 500 Arcola Road PO Box 5096 0800

Proctor and Gamble 8700 Mason-Montgomery Pharmaceuticals Road Mason OH 08807

South San Francisco CA Genentech, Inc. 1 DNA Way 94080-4990

South San Francisco CA Genentech, Inc. 1 DNA Way 94080-4990 South San Francisco CA Genentech, Inc. 1DNA Way MS 241A 94080

AVI BioPharma, Inc. One SW Columbia Street Portland OR 97258

MERCK & Co., Inc. 126 East Lincoln Ave. Rahway NJ 07065

Gloucester Pharmaceuticals, Inc. One Broadway Cambridge MA 02142

Kalamazoo MI 49001- Pharmacia & Upjohn 7000 Portage Road 0199

Provectus Pharmaceuticals, Inc. 7327 Oak Ridge Highway Knoxville TN 37931

Byk Gulden Pharmaceuticals Byk-Gulden StraBe 2 78467 Konstanz GERMANY

Altana Pharma 220 Park avenue Florham Park NJ 07932 Dublin CA SuperGen, Inc. 4140 Dublin Blvd. Suite 200 94568

EntreMed Incorporated 9640 Medical Center Dr. Rockville MD 20850

Genopia USA, Inc. 90 Gold Street, 6N New York NY 10038 1550 Sawgrass Corporate Concordia Pharmaceuticals, Inc. Parkway Sunrise FL 33323 Godmanchester, Cambridgeshire PE29 Phytopharm plc Corpus Christi House 2HY UNITED KINGDOM

SmithKline Beecham Collegeville PA 19426- Pharmaceuticals 1250 S. Collegeville Road 0989

666 Sherbrooke Street Debiovision Inc. West, Suite 1400 Montreal, Quebec

Schering Corporation 2000 Galloping Hill Rd. Kenilworth NJ 07033

Chemokine Therapeutics 190 Agronomy Road Vancouver, Corporation (UBC) Suite 405 BC V6T 1Z3 CANADA

Teva Pharmaceuticals USA 650 Cathill Rd. Sellersville PA 18960

Synergen, Inc. 1885 33rd Street Boulder CO 80301

Neotropix, Inc. 351 Phoenixville Pike Malvern PA 19355

EMD Serono, Inc. One Technology Place Rockland MA 02370

EMD Serono, Inc. One Technology Place Rockland MA 02370

Cell Technology, Inc. 1668 Valtec Lane Boulder CO 80306 21823 30th Drive Seattle Genetics, Inc. Southeast Bothell WA 98021

21823 30th Drive, Seattle Genetics, Inc Southeast Bothell WA 98021

21823 30th Drive Seattle Genetics, Inc. Southeast Bothell WA 98021 21823 30th Drive Seattle Genetics, Inc. Southeast Bothell WA 98021 1000 Central Street, Suite Richard I. Breuer, M.D. 615 Evanston IL 60201 1000 Central Street, Suite Richard I. Breuer 615 Evanston IL 60201

Paoli PA Synthes (USA) 1690 Russell Road PO Box 1766 19301

MedImmune, LLC One MedImmune Way Gaithersburg 20878

Pfizer Global Research and 50 Pequot Avenue 6025- Development B4137 New London CT 06320

SmithKline Beecham Pharmaceuticals One Franklin Plaza Philadelphia PA 19101

HemaQuest Pharmaceuticals, Inc. 101 Federal Street Boston MA 02110

Millennium Pharmaceuticals, Inc. 40 Landsdowne Street Cambridge MA 02139

Framework Therapeutics, LLc 1564 33rd Street, NW Washington DC 20007

IC-MedTech Corporation 9902 Indian Creek Lane El Cajon CA 92021

Gainesville Stacpoole, Peter W. M.D., Ph.D. University of Florida P.O. Box 100277 FL 32610 Gainesville Stacpoole, Peter W. M.D., Ph.D. University of Florida P.O. Box 100277 FL 32610

Questcor Pharmaceuticals, Inc. 3260 Whipple Rd. Union City CA 94587-1217

Gainesville Stacpoole, Peter W. M.D., Ph.D. University Of Florida P.O. Box 100277 FL 32610

Carlsbad CA EBD Group 2032 Corte del Nogal Suite 120 92011 Questcor Pharmaceuticals, Inc. 3260 Whipple Rd. Union City CA 94587-0700

Neutron Technology Corp.& 877 Main Street, Suite Neutron R&D Partner 402 Boise ID 83702

Theragenics Corporation 8260 E. Gelding Drive Hope Pharmaceuticals, Inc #104 Scottsdale AZ 85260

Hope Pharmaceuticals 8260 East Gelding Drive Scottsdale AZ 85260

Hope Pharmaceuticals 8260 E. Gelding Drive Scottsdale AZ 85260

San Diego Aires Pharmaceuticals, Inc. 4690 Executive Drive Suite 150 CA 92121

Hope Pharmaceuticals 8260 E. Gelding Drive Scottsdale AZ 85260

Keystone Pharmaceuticals, Inc. 26072 Merit Circle Laguna Hills CA 92653

Ucyclyd Pharma, Inc. 8125 North Hayden Road Scottsdaale AZ 85258

Tikvah Therapeutics, Inc. 75 5th Street, NW. Atlanta GA 30308

Ucyclyd Pharma, Inc. 8125 N. Hayden Road Scottsdale AZ 85258

Elan Drug Delivery, Inc. 1300 Gould Dr. Gainesville GA 30504

Medicis Pharmaceutical Corp. 8125 N. Hayden Road Scottsdale AZ 85258

Flemington Cellular Sciences, Inc. 84 Park Avenue P. O. Box 968 NJ 08822 Basking Ridge NJ VioQuest Pharmaceuticals, Inc. 180 Mt. Airy Road Suite 102 07920

Durham NC Adherex Technologies, Inc. 4620 Creekstone Drive Suite 200 27703

Akorn, Inc. 2500 Millbrook Drive Buffalo Grove IL 60089

Keystone Pharmaceuticals, Inc. 26072 Merit Circle Laguna Hills CA 92653

Solbec Pharmaceuticals Limited P. O. Box 2142 WA 6018 AUSTRALIA

Osbourne Park, Western Solbec Pharmaceuticals Limited P. O. Box 2142 Australia 6017 AUSTRALIA

Avant Immunotherapeutics, Inc. 119 Fourth Ave. Needham MA 02494-2725 Needham Heights MA T Cell Sciences, Inc. 119 Fourth Avenue 02194

Hoboken NJ Octapharma USA, Inc. 121 River Street 12th Floor 07030

400 Rella Boulevard, Ferring Laboratories, Inc. Suite 201 Suffern NY 10901

UCB, Inc. 1950 Lake Park Drive Smyrna GA 30080 460 Point San Bruno South San Francisco CA Genentech, Inc. Boulevard 94080

Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285 Princeton NJ Novo Nordisk Pharmaceuticals 100 Overlook Center Suite 200 08540 Princeton NJ Novo Nordisk Pharmaceuticals 100 Overlook Center Suite 200 08540 Bio-Technology General Corp. 70 Wood Avenue, South Iselin NJ 08830

EMD Serono, Inc. One Technology Place Rockland MA 02370

EMD Serono, Inc. One Technology Place Rockland MA 02370

EMD Serono, Inc. One Technology Place Rockland MA 02370

Bayer Pharmaceuticals Corp. 400 Morgan Lane New Haven CT 06516 Wallingford Bristol-Myers Squibb 5 Research Parkway P.O. Box 5100 CT 06492

Berlex Laboratories, Inc. 300 Fairfield Road Wayne NJ 07470

Ocera Therapeutics, Inc. 12651 High Bluff Drive San Diego CA 92130

Rhone-Poulenc Rorer Pharmaceuticals 500 Arcola Road Collegeville PA 19426

Plymouth Meeting PA Genaera Corporation 5110 Campus Drive 19462 Cancer Therapy Evaluation Rockville MD National Institutes of Health Program/DCTD/NCI Suite 7111 20852

Cancer Therapy Rockville MD National Institutes of Health Evaluation Program NCI/DCTD 20852

Sanofi Winthrop, Inc. 9 Great Valley Parkway Malvern PA 19355

Sanofi Winthrop, Inc. 9 Great Valley Parkway Malvern PA 19355

Biotest Pharmaceuticals 5800 Park of Commerce Corporation Blvd, NW Boca Raton FL 33487 Gamida Cell Ltd 5, Nahum Hafzadi St. Jerusalem 95484 ISRAEL

Avenue du Vent des Novatech SA Dames - Z.l. les Paluds 13685 Aubagne FRANCE

Avenue du Vent des Novatech SA Dames - Z.l. les Paluds 13685 Aubagne FRANCE

Biocodex 7, avenue Gallieni 94250 Gentilly FRANCE

South San Francisco CA Sugen, Inc. 230 East Grand Ave. 94080-4811

South San Francisco CA Sugen, Inc. 230 East Grand Ave. 94080-4811

Sanofi Winthrop, Inc. 90 Park Avenue New York NY 10016-1389

Sanofi Winthrop, Inc. 90 Park Avenue New York NY 10016-1389

Fuisz Technologies, Ltd. 14555 Avion at Lakeside Chantilly VA 20151

Rockville Centre NY Darby Pharmaceuticals, Inc. 100 Banks Avenue 11570

Rockville Centre NY Darby Pharmaceuticals, Inc. 100 Banks Avenue 11570 Shire Human Genetic Therapies, Inc. 700 Main Street Cambridge MA 02139

Jacobus Pharmaceutical Princeton NJ Company 37 Cleveland Lane P.O. Box 5290 08540

Pharmacia-Chiron Partnership 4560 Horton Street Emeryville CA 94608 Bio-Technology General Corp. 70 Wood Avenue, South Iselin NJ 08830 Parke-Davis Pharmaceutical Research Ann Arbor MI Warner-Lambert Company Division 2800 Plymouth Road 48105-2430

Merritt, T. Allen M.D. 2516 Stockton Boulevard Sacramento CA 95817

201, 1204 Kensington Synsorb Biotech Inc. Road, N.W. Calgary, Alberta CANADA

Rare Disease Therapeutics, Inc. 2550 Meridian Blvd Nashville TN 37217

Repligen Corporation 41 Seyon Street Waltham MA 02453

Silver Spring MD 20905- ChiRhoClin, Inc. 15500 Gallaudet Ave. 4176

Silver Spring MD 20905- ChiRhoClin, Inc. 15500 Gallaudet Ave. 4176

Silver Spring MD 20905- ChiRhoClin, Inc. 15500 Gallaudet Ave. 4176

Silver Spring MD 20905- ChiRhoClin, Inc. 1550 Gallaudet Ave. 4176

Silver Spring MD 20905- ChiRhoClin, Inc. 15500 Gallaudet Ave. 4176

AGI Dermatics 205 Buffalo Avenue Freeport NY 11520

Fujisawa USA, Inc. 3 Parkway North Center Deerfield IL 60015

Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285 Tap Holdings Inc. 2355 Waukegan Road Deerfield IL 60015

Agennix, Inc. 8 Greenway Plaza Houston TX 77046

Houston TX Agennix, Inc. 8 Greenway Plaza Suite 910 77046

Houston TX Agennix, Inc. Greenway Plaza Suite 910 77046

Houston TX Agennix, Inc. 8 Greenway Plaza Suite 910 77046

TEVA Neuroscience, Inc. 425 Privet Road Horsham PA 19044-8005

TEVA Neuroscience P. O. Box 1005 Horsham PA 19044-8005

San Diego CytRx Corporation 3030 Bunker Hill Road Suite 101 CA 92109 Wallingford research and CT 06492- Bristol-Myers Squibb Development 5 Research Parkway 7660

Nexell Therapeutics Inc. 9 Parker Irvine CA 92618-1605

TransDerm, Inc. 2161 Delaware Aenue Santa Cruz CA 95060

Endocyte, Inc. 1205 Kent Ave. West Lafayette IN 47906

NeoRx Corporation 410 West Harrison Seattle WA 98119-4007

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950 Immunomedics, Inc. 300 American Road Morris Plains NJ 07950 Cambridge Theseus Imaging Corporation 124 Mount Auburn Street Suite 200 North MA 02138

Taiho Pharma USA, Inc. 210 Carnegie Center Princeton NJ 08540

67 Winston Churchill Belpharma N.V. Avenue Brussels BELGIUM

Biolitec Pharma Ireland Ltd. United Drug House Dublin IRELAND Schering-Plough Research Institute 2000 Galloping Hill Road Kenilworth NJ 07033

Schering-Plough Research Institute 2000 Galloping Hill Rd. Kenilworth NJ 07033

Gilead Sciences, Inc. 333 Lakeside Drive Foster city CA 94404

ErgoNex Pharma GmbH Ruetistr. 20 CH-9050 Appenzell SWITZERLAND

Biomeasure, Inc. 27 Maple St. Milford MA 01757-3650

400 Rella Boulevard, Ferring Laboratories, Inc. Suite 201 Suffern NY 10901

Round Valley Executive Lebanon NJ Orphan Therapeutics, LLC 3 Werner Way Center 08833

Genta, Inc. 200 Connell Drive Berkley Heights NJ 07922

Berkeley Heights NJ Genta Inc. 200 Connell Drive 07922

Salt Lake City Watson Laboratories Research Park 417 Wakara Way UT 84108 Star Pharmaceuticals, Inc. 1990 N.W. 44th Street Pompano Beach FL 33064

Bio-Technology General Corp. 70 Wood Avenue South Iselin NJ 08830

Washington Prestwick Pharmaceuticals, Inc. 1825 K Street, NW Suite 1475 DC 20006

Underhill VT Danforth, Jr., MD, Elliot University of Vermont 84 Beartown Rd. 05489

Sanofi-Aventis Pharma 9 Great valley Parkway Malvern PA 19355-1304

Antisense Pharma GmbH Josef-Engert-Str. 9 93053 Regensberg GERMANY

Kuros Biosurgery AG Technoiparkstrasse 1 Zurich SWITZERLAND

Celgene Corporation 86 Morris Avenue Summit NJ 07901

11800 Baltimore Avenue, Andrulis Research Corporation Suite 113 Beltsville MD 20705

Warren NJ Celgene Corporation P.O. Box 4914 7 Powder Horn Drive 07059

Celgene Corporation 7 Powder Horn Dr. Warren NJ 07059

Pediatric Pharmaceuticals, Inc. 718 Bradford Avenue Westfield NJ 07090

Pediatric Pharmaceuticals, Inc. 718 Bradford Avenue Westfield NJ 07090

Pediatric Pharmaceuticals, Inc. 718 Bradford Avenue Westfield NJ 07090

Warren NJ Celgene Corporation P.O. Box 4914 7 Powder Horn Drive 07059 11800 Baltimore Avenue, Andrulis Research Corporation Suite 113 Beltsville MD 20705

11800 Baltimore Avenue, Andrulis Research Corporation Suite 113 Beltsville MD 20705

Celgene Corporation 7 Powder Horn Dr. Warren NJ 07059

Warren NJ Celgene Corporation P.O. Box 4914 7 Powder Horn Srive 07059

Celgene Corporation 7 Powder Horn Dr. Warren NJ 07059 24128 Bergamo, 64/B Adienne S.r.l. Broseta Street Bergamo ITALY

SciClone Pharmaceuticals, Inc. 901 Mariner's Island Blvd San Mateo CA 94404 Foster City CA 94404- SciClone Pharmaceuticals, Inc. 950 Tower Lane Suite 900 2125

San Mateo CA 94404- SciClone Pharmaceuticals, Inc. 901 Mariner's Island Blvd. 1593

901 Mariner's Blvd., Suite San Mateo CA 94404- SciClone Pharmaceuticals, Inc. 205 1593

RegeneRx Biopharmaceuticals, Bethesda MD Inc. 3 Bethesda Metro Center Suite 700 20814

Iolab Pharmaceuticals 500 Iolab Drive Claremont CA 91711

Malvern PA Sanofi-Synthelabo, Inc. 9 Great Valley Parkway PO Box 3026 19355

Valeant Research & Development 3300 Hyland Avenue Costa Mesa CA 92626 Arginox Pharmceuticals, Inc. 120 Constitution Drive Menlo Park CA 94025

Miravant Medical Technologies 336 Bollay Drive Goleta CA 93117

Boehringer Ingelheim Ridgefield CT Pharmaceuticals, Inc. P. O. Box 368 900 Ridgebury Road 06877 Pharmaceutical Research & Dev. 920 U.S. Highway 202 Raritan NJ 08869 Malvern PA Sanofi-Aventis US, Inc. 11 Great Valley Parkway P. O. Box 3026 19355

48 Bis, Rue des Belles- Laphal Laboratoires Feuilles 75116 Paris FRANCE

24 Frank Lloyd Wright Ann Arbor MI Aastrom Biosciences, Inc. Domino's Farms Drive 48105

Aastrom Biosciences, Inc. Domino's Farms, Lobby L Ann Arbor MI 48105

Parc Technologique Du 31521 Ramonville Saint Orfagen Canal-4 Agne FRANCE

South San Francisco CA Athena Neurosciences, Inc. 800 Gateway Boulevard 94080 East Hanover NJ 07936- Novartis Pharmaceuticals Corp. Drug Regulatory Affairs One Health Plaza 1080

Axentis Pharma AG 138 Limmatquai CH-8001 Zurich SWITZERLAND

Sterling Winthrop 9 Great Valley Parkway Malvern PA 19355

Biogen IDEC Inc. 3030 Callan Road San Diego CA 92121

Orion Corporation P.O. Box 65 02101 Espoo FINLAND Chroma Therapeutics Ltd. 93 Milton Park Oxfordshire OX14 4RY UNITED KINGDOM Johnson & Johnson Pharmaceutical Research & Raritan NJ Dev. 920 US Highway 202 P. O. Box 300 08869

Ortho Biotech Oncology Research & Development 920 U S Highway 202 Raritan NJ 08869

TheraQuest Biosciences, LLC 146 Medinah Drive Blue Bell PA 19422-3212

TheraQuest Biosciences, LLC 146 Medinah Drive Blue Bell PA 19422-3212

Pharmacia Inc. P.O. Box 16529 Columbus OH 43216

Pharmacia Inc. P.O. Box 16529 Columbus OH 43216

Angiogen Pharmaceuticals, Pty. Level 31, ABN AMRO 88 Phillip Street Sydney, Ltd. Tower N.S.W. 2000 AUSTRALIA

Celtrix Pharmaceuticals, Inc. 3055 Patrick Henry Drive Santa Clara CA 95054

PPL Therapeutics (Scotland) Limited Roslin, Edinburgh EH259PP Scotland UNITED KINGDOM

South San Francisco CA Genentech, Inc. 1 DNA Way 94080-4990

Medac GmbH Fehlandtstrasse 3 D-20354 Hamburg GERMANY

Antigenics, Inc. 3 Forbes Road Lexington MA 02421

Antigenics, Inc. 3 Forbes Road Lexington MA 02421 Hannan Ophthalmic Marketing Services, Inc 34 Sherrill Rd. Marshfield MA 02050

Cell Works Inc. 6200 Seaforth Street Baltimore MD 21224-6506

VioQuest Pharmaceuticals, Inc. 180 Mt. Airy Road Basking Ridge NJ 07920 Baylor Research Institute 3330 Live Oak Blvd Dallas TX 75204 Institute of Metabolic Dallas TX Baylor Research Institute Disease 3812 Elm Street 75226

Medimmune Oncology, Inc. One MedImmune Way Gaithersburg MD 20878

Medimmune Oncology, Inc. One MedImmune Way Gaithersburg MD 20878

Medimmune Oncology, Inc. One MedImmune Way Gaithersburg MD 20878

Medimmune Oncology, Inc. One MedImmune Way Gaithersburg MD 20878

Medimmune Oncology, Inc. One MedImmune Way Gaithersburg MD 20878

7929 Westpark Drive, Debio R.A. Inc. Suite 400 Mclean VA 22102

Chembiomed, Ltd. P.O. Box 8050, Station F Edmonton, Alberta CANADA

Chembiomed, Ltd. P.O. Box 8050 Edmonton, Alberta CANADA

Chembiomed, Ltd. P.O. Box 8050 Edmonton, Alberta CANADA

Chembiomed, Ltd. P.O. Box 8050 Edmonton, Alberta CANADA

Hemotec Medical Products, Inc. Box 19255 Johnston RI 02919

CustomCare Pharmacy 5710 Hoover Blvd Tampa FL 33634

Structural GenomiX, Inc. (SGX) 10505 Roselle Street San Diego CA 92121

EMD Serono, Inc. One Technology Place Rockland MA 02370 EMD Serono, Inc. One Technology Place Rockland MA 02370 Salt Lake City University of Utah Health 50 North Medical Drive, UT 84132- Kennedy & Hoidal, M.D.'s Sciences Center Room 4R240 0001 arGentis Pharmaceuticals, LLC 20 South Dudley Street Memphis TN 38139

AB Science 3, avenue GeorgeV 75008 Paris FRANCE Gel-Tec, Division of Tishcon Westbury NY Corp 30 New York Avenue P. O. Box 331 11590

Gel-Tec, Division of TISHCON Westbury NY Corporation 30 New York Avenue P.O. Box 331 11590

Gel-Tec, Division of Tishcon Westbury NY Corp. 30 New York Ave. PO Box 331 11590

Wilex Biotechnology GmbH Grillparzerstrasse 10B 81675 Munich GERMANY

Vitreo Retinal Techologies, Inc 2 Venture Plaza Irvine CA 92618 4222 Emperor Boulevard, Inspire Pharmaceuticals, Inc. Suite 470 Durham NC 27703

4222 Emperor Boulevard, Inspire Pharmaceuticals, Inc. Suite 470 Durham NC 27703

EMD Serono, Inc. One Technology Place Rockland MA 02370

Chiron Vision 500 Iolab Drive Claremont CA 91711 Asklepion Pharmaceuticals, LLC 5200 Maryland Way Brentwood TN 37027

Novartis Pharmaceuticals East Hanover NJ 07936- Corporation 59 Route 10 1080

Leas Research Products 78 Fallon Drive North Haven CT 06473

Leawood KS Verenta Pharmaceuticals, Inc. 10901 Granada Lane Suite 101 66211

Neuropharm Ltd, Fetcham Park House Surrey KT22 9HD UNITED KINGDOM

Topo Target Germany AG Paul-Ehrlich Str. 42-44 D-60596 Frankfurt am Main GERMANY

Wilmington DE 19830- AstraZeneca Pharmaceutical LP 1800 Concord Pike 8355 666 Sherbrooke Street H3 Pharma, Inc. West Suite 1400 Montreal, Quebec, CANADA Montreal, 666 Sherbrooke Street Quebec H3A Debiovision, Inc. West Suite 1400 1E7 CANADA

Debiopharm S.A. 17 rue des Terreaux CH-1000 Lausanne 9 SWITZERLAND

Debiopharm S.A. 17 rue des Terreaux CH-1000 Lausanne 9 SWITZERLAND

666 Sherbrooke Street H3 Pharma, Inc. West, Suite 1400 Montreal, Quebec

Hayward CA Anthera Pharmaceuticals, Inc. 25801 Industrial Blvd. Suite B 94545

Cangene Corporation 155 Innovation Drive R3T 5Y3 CANADA

PhiloGene, Inc. 174 Summit Avenue Summit NJ 07901 mondoBIOTECH Europark Austrasse 79

Research Triangle 200 Westpark Corporate Durham NC Pharmaceuticals Center 4364 South Alston Avenue 27713-2280

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

BioMarin Pharmaceutical Inc. 105 Digital Drive Novato CA 94949

Ovation Pharmaceuticals, Inc. Four Parkway North Deerfield IL 60015

Stuart Pharmaceuticals Division of ICI Americas Wilmington DE 19897

Stuart Pharmaceuticals Division of ICI Americas Wilmington DE 19897

South San Francisco CA Hana Biosciences, Inc. 7000 Shoreline Court 94080 South San Francisco CA Hana Biosciences, Inc 7000 Shoreline Court Suite 370 94080 100-A Eastwood Center Wilmington ZOR Pharmaceuticals, LLC Drive Suite 118 NC 28403

San Diego Meritage Pharma, Inc. 12481 High Bluff Drive Suite 160 CA 92130

Wellstat Therapeutics Corp. 930 Clopper Road Gaithersburg MD 20878

Rahway NJ Merck Research Laboratories Merck & Co., Inc. P. O. Box 2000, RY 32-605 07065-0900

P. O. Box 2000, RY 32- Merck & Co., Inc. 605 Rahway NJ 07065-0900

VAXON-Biotech 3-5 impasse Reille FRANCE Circe Biomedical, Inc. 99 Hayden Ave. Lexington MA 02421-7995

MAT Biopharma 4 rue Pierre Fontaine FRANCE

Immunomedics, Inc. 300 American Rd. Morris Plains NJ 07950

NIH, Executive Plaza National Cancer Institute, DCT North, Room 7-18 Bethesda MD 20892

Kanisa Pharmaceuticals, Inc. 12264 El Camino Real San Diego CA 02130