Article No Evidence for Recent Selection at FOXP2 among Diverse Human Populations Graphical Abstract Authors Elizabeth Grace Atkinson, Amanda Jane Audesse, Julia Adela Palacios, Dean Michael Bobo, Ashley Elizabeth Webb, Sohini Ramachandran, Brenna Mariah Henn Correspondence
[email protected] (E.G.A.),
[email protected] (B.M.H.) In Brief An in-depth examination of diverse sets of human genomes argues against a recent selective evolutionary sweep of FOXP2, a gene that was believed to be critical for speech evolution in early hominins. Highlights d No support for positive selection at FOXP2 in large genomic datasets d Sample composition and genomic scale significantly affect selection scans d An intronic ROI within FOXP2 is expressed in human brain cells and cortical tissue d This ROI contains a large amount of constrained, human- specific polymorphisms Atkinson et al., 2018, Cell 174, 1424–1435 September 6, 2018 ª 2018 Elsevier Inc. https://doi.org/10.1016/j.cell.2018.06.048 Article No Evidence for Recent Selection at FOXP2 among Diverse Human Populations Elizabeth Grace Atkinson,1,8,9,10,* Amanda Jane Audesse,2,3 Julia Adela Palacios,4,5 Dean Michael Bobo,1 Ashley Elizabeth Webb,2,6 Sohini Ramachandran,4 and Brenna Mariah Henn1,7,* 1Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY, USA 2Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA 3Neuroscience Graduate Program, Brown University, Providence, RI 02912, USA 4Department of Ecology and Evolutionary