Tomono et al.: Glycan evolution based on phylogenetic profiling 1

Supplementary Table S1. List of 173 enzymes that are composed of glycosyltransferases and functionally-linked glycan synthetic enzymes UniProt ID Protein Name Categories of Glycan Localization CAZy Class 1 Q8N5D6 Globoside -1,3-N -acetylgalactosaminyltransferase 1 Glycosphingolipid Golgi apparatus GT6 P16442 Histo-blood group ABO system transferase Glycosphingolipid Golgi apparatus GT6 P19526 Galactoside 2--L-fucosyltransferase 1 Glycosphingolipid Golgi apparatus GT11 Q10981 Galactoside 2--L-fucosyltransferase 2 Glycosphingolipid Golgi apparatus GT11 Q00973 -1,4 N -acetylgalactosaminyltransferase 1 Glycosphingolipid Golgi apparatus GT12 Q8NHY0 -1,4 N -acetylgalactosaminyltransferase 2 O -Glycan, N -Glycan, Glycosphingolipid Golgi apparatus GT12 Q09327 -1,4-mannosyl-glycoprotein 4--N -acetylglucosaminyltransferase N -Glycan Golgi apparatus GT17 Q09328 -1,6-mannosylglycoprotein 6--N -acetylglucosaminyltransferase A N -Glycan Golgi apparatus GT18 Q3V5L5 -1,6-mannosylglycoprotein 6--N -acetylglucosaminyltransferase B O -Glycan, N -Glycan Golgi apparatus GT18 Q92186 -2,8-sialyltransferase 8B (SIAT8-B) (ST8SiaII) (STX) N -Glycan Golgi apparatus GT29 O15466 -2,8-sialyltransferase 8E (SIAT8-E) (ST8SiaV) Glycosphingolipid Golgi apparatus GT29 P61647 -2,8-sialyltransferase 8F (SIAT8-F) (ST8SiaVI) O -Glycan Golgi apparatus GT29 Q9NSC7 -N -acetylgalactosaminide -2,6-sialyltransferase 1 (ST6GalNAcI) (SIAT7-A) O -Glycan Golgi apparatus GT29 Q9UJ37 -N -acetylgalactosaminide -2,6-sialyltransferase 2 (ST6GalNAcII) (SThM) (SIAT7-B) O -Glycan Golgi apparatus GT29 Q8NDV1 -N -acetylgalactosaminide -2,6-sialyltransferase 3 (ST6GalNAcIII) (SIAT7-C) Glycosphingolipid Golgi apparatus GT29 Q9BVH7 -N -acetylgalactosaminide -2,6-sialyltransferase 5 (ST6GalNAcV) (SIAT7-E) Glycosphingolipid Golgi apparatus GT29 Q969X2 -N -acetylgalactosaminide -2,6-sialyltransferase 6 (ST6GalNAcVI) (SIAT7-F) Glycosphingolipid Golgi apparatus GT29 Q92185 -N -acetylneuraminide -2,8-sialyltransferase (Ganglioside GD3 synthase) (SIAT8-A) (ST8SiaI) Glycosphingolipid Golgi apparatus GT29 -N -acetyl-neuraminyl-2,3--galactosyl-1,3-N -acetyl-galactosaminide -2,6-sialyltransferase Q9H4F1 Glycosphingolipid Golgi apparatus GT29 (ST6GalNAcIV) (SIAT3-C) (SIAT7-D) P15907 -galactoside -2,6-sialyltransferase 1 (ST6GalI) O -Glycan, N -Glycan Golgi apparatus GT29 Q96JF0 -galactoside -2,6-sialyltransferase 2 (ST6GalII) O -Glycan, N -Glycan Golgi apparatus GT29 Q11203 CMP-N -acetylneuraminate--1,4-galactoside -2,3-sialyltransferase (ST3GalIII) (Sialyltransferase 6) O -Glycan, Glycosphingolipid, Proteoglycan Golgi apparatus GT29 Q11201 CMP-N -acetylneuraminate--galactosamide--2,3-sialyltransferase 1 (ST3GalI) (SIAT4-A) O -Glycan, Glycosphingolipid, Proteoglycan Golgi apparatus GT29 Q16842 CMP-N -acetylneuraminate--galactosamide--2,3-sialyltransferase 2 (ST3GalII) (SIAT4-B) O -Glycan, Glycosphingolipid, Proteoglycan Golgi apparatus GT29 Q11206 CMP-N -acetylneuraminate--galactosamide--2,3-sialyltransferase 4 (ST3GalIV) (STZ) (SIAT4-C) Glycosphingolipid Golgi apparatus GT29 Q92187 CMP-N -acetylneuraminate-poly--2,8-sialyltransferase (SIAT8-D) (ST8SiaIV) N -Glycan Golgi apparatus GT29 Q9UNP4 Lactosylceramide -2,3-sialyltransferase (Ganglioside GM3 synthase) (ST3GalV) (Sialyltransferase 9) Glycosphingolipid Golgi apparatus GT29 O43173 Sia--2,3-Gal--1,4-GlcNAc-R: 2,8-sialyltransferase (SIAT8-C) (ST8SiaIII) N -Glycan, Glycosphingolipid Golgi apparatus GT29 Q9Y274 Type 2 lactosamine -2,3-sialyltransferase (ST3GalVI) (Sialyltransferase 10) Glycosphingolipid Golgi apparatus GT29 Q9UNA3 -1,4-N -acetylglucosaminyltransferase O -Glycan Golgi apparatus GT32 Q9NPC4 Lactosylceramide 4--galactosyltransferase Glycosphingolipid Golgi apparatus GT32 Q8NAT1 Glycosyltransferase-like domain-containing protein 2 O -Glycan Extracellular GT61 O94777 Dolichol phosphate-mannose biosynthesis regulatory protein N -Glycan, GPI anchor Endoplasmic reticulum - Q9P2X0 Dolichol-phosphate mannosyltransferase subunit 3 N -Glycan Endoplasmic reticulum - P0C6T2 Dolichyl-diphosphooligosaccharideprotein glycosyltransferase subunit 4 N -Glycan Endoplasmic reticulum - Q3MUY2 Phosphatidylinositol N -acetylglucosaminyltransferase subunit Y GPI anchor Endoplasmic reticulum - Q8TBF5 Phosphatidylinositol-glycan biosynthesis class X protein GPI anchor Endoplasmic reticulum - Endoplasmic reticulum, Cytoplasm, Q14442 Phosphatidylinositol N -acetylglucosaminyltransferase subunit H GPI anchor - Mitochondria, Nucleus O75072 Fukutin O -Glycan Golgi apparatus+Endoplasmic reticulum - Tomono et al.: Glycan evolution based on phylogenetic profiling 2

Supplementary Table S1. List of 173 enzymes that are composed of glycosyltransferases and functionally-linked glycan synthetic enzymes UniProt ID Protein Name Categories of Glycan Localization CAZy Class 2 Q16880 2-hydroxyacylsphingosine 1--galactosyltransferase Glycosphingolipid - GT1 O -Glycan, N -Glycan, Glycosphingolipid, P15291 -1,4-galactosyltransferase 1 Golgi apparatus GT7 Proteoglycan O60909 -1,4-galactosyltransferase 2 O -Glycan, N -Glycan, Proteoglycan Golgi apparatus GT7 O -Glycan, N -Glycan, Glycosphingolipid, O60512 -1,4-galactosyltransferase 3 Golgi apparatus GT7 Proteoglycan O60513 -1,4-galactosyltransferase 4 Glycosphingolipid, Proteoglycan Golgi apparatus GT7 O43286 -1,4-galactosyltransferase 5 O -Glycan Golgi apparatus GT7 Q9UBX8 -1,4-galactosyltransferase 6 Glycosphingolipid Golgi apparatus GT7 Q9UBV7 -1,4-galactosyltransferase 7 Proteoglycan Golgi apparatus GT7 Q6L9W6 -1,4-N -acetylgalactosaminyltransferase 3 N -Glycan Golgi apparatus GT7 Q8TDX6 Chondroitin sulfate N -acetylgalactosaminyltransferase 1 Proteoglycan Golgi apparatus GT7 Q8N6G5 Chondroitin sulfate N -acetylgalactosaminyltransferase 2 Proteoglycan Golgi apparatus GT7 Q76KP1 N -acetyl--glucosaminyl-glycoprotein 4--N -acetylgalactosaminyltransferase 1 N -Glycan Golgi apparatus GT7 Q86X52 Chondroitin sulfate synthase 1 Proteoglycan Golgi apparatus GT7, GT31 Q8IZ52 Chondroitin sulfate synthase 2 Proteoglycan Golgi apparatus GT7, GT31 Q70JA7 Chondroitin sulfate synthase 3 Proteoglycan Golgi apparatus GT7, GT31 A0PJZ3 Glucoside xylosyltransferase 2 O -Glycan - GT8 Q8NBI6 Xyloside xylosyltransferase 1 O -Glycan Endoplasmic reticulum GT8 Q4G148 Glucoside xylosyltransferase 1 O -Glycan Golgi apparatus GT8 Q6P4F1 -(1,3)-fucosyltransferase 10 N -Glycan Golgi apparatus GT10 P22083 -(1,3)-fucosyltransferase 4 O -Glycan, Glycosphingolipid Golgi apparatus GT10 Q11128 -(1,3)-fucosyltransferase 5 Glycosphingolipid Golgi apparatus GT10 P51993 -(1,3)-fucosyltransferase 6 Glycosphingolipid Golgi apparatus GT10 Q11130 -(1,3)-fucosyltransferase 7 O -Glycan, Glycosphingolipid Golgi apparatus GT10 Q9Y231 -(1,3)-fucosyltransferase 9 O -Glycan, Glycosphingolipid Golgi apparatus GT10 P21217 Galactoside 3(4)-L-fucosyltransferase Glycosphingolipid Golgi apparatus GT10 P26572 -1,3-mannosyl-glycoprotein 2--N -acetylglucosaminyltransferase N -Glycan Golgi apparatus GT13 Q8WZA1 Protein O -linked-mannose -1,2-N -acetylglucosaminyltransferase 1 O -Glycan Golgi apparatus GT13 Q02742 -1,3-galactosyl-O -glycosyl-glycoprotein -1,6-N -acetylglucosaminyltransferase O -Glycan Golgi apparatus GT14 O95395 -1,3-galactosyl-O -glycosyl-glycoprotein -1,6-N -acetylglucosaminyltransferase 3 O -Glycan Golgi apparatus GT14 Q9P109 -1,3-galactosyl-O -glycosyl-glycoprotein -1,6-N -acetylglucosaminyltransferase 4 O -Glycan Golgi apparatus GT14 Q6ZNI0 -1,3-galactosyl-O -glycosyl-glycoprotein -1,6-N -acetylglucosaminyltransferase 7 O -Glycan Golgi apparatus GT14 Q06430 N -acetyllactosaminide -1,6-N -acetylglucosaminyl-transferase, isoform B Glycosphingolipid Golgi apparatus GT14 Q86Y38 Xylosyltransferase 1 Proteoglycan Golgi apparatus+Endoplasmic reticulum GT14 Q9H1B5 Xylosyltransferase 2 Proteoglycan Golgi apparatus+Endoplasmic reticulum GT14 Q10469 -1,6-mannosyl-glycoprotein 2--N -acetylglucosaminyltransferase N -Glycan Golgi apparatus GT16 Q9BYC5 -(1,6)-fucosyltransferase N -Glycan, Proteoglycan Golgi apparatus GT23 Q8NBJ5 Procollagen galactosyltransferase 1 O -Glycan Endoplasmic reticulum GT25 Q8IYK4 Procollagen galactosyltransferase 2 O -Glycan Endoplasmic reticulum GT25 Q7Z4T8 Putative polypeptide N -acetylgalactosaminyltransferase-like protein 5 O -Glycan Golgi apparatus GT27 Q86SF2 N -acetylgalactosaminyltransferase 7 O -Glycan Golgi apparatus GT27, CBM13 Q10472 Polypeptide N -acetylgalactosaminyltransferase 1 O -Glycan Golgi apparatus GT27, CBM13 Q10471 Polypeptide N -acetylgalactosaminyltransferase 2 O -Glycan Golgi apparatus GT27, CBM13 Q14435 Polypeptide N -acetylgalactosaminyltransferase 3 O -Glycan Golgi apparatus GT27, CBM13 Q8N4A0 Polypeptide N -acetylgalactosaminyltransferase 4 O -Glycan Golgi apparatus GT27, CBM13 Q7Z7M9 Polypeptide N -acetylgalactosaminyltransferase 5 O -Glycan Golgi apparatus GT27, CBM13 Q8NCL4 Polypeptide N -acetylgalactosaminyltransferase 6 O -Glycan Golgi apparatus GT27, CBM13 Q9HCQ5 Polypeptide N -acetylgalactosaminyltransferase 9 O -Glycan Golgi apparatus GT27, CBM13 Q86SR1 Polypeptide N -acetylgalactosaminyltransferase 10 O -Glycan Golgi apparatus GT27, CBM13 Q8NCW6 Polypeptide N -acetylgalactosaminyltransferase 11 O -Glycan Golgi apparatus GT27, CBM13 Tomono et al.: Glycan evolution based on phylogenetic profiling 3

Supplementary Table S1. List of 173 enzymes that are composed of glycosyltransferases and functionally-linked glycan synthetic enzymes UniProt ID Protein Name Categories of Glycan Localization CAZy Q8IXK2 Polypeptide N -acetylgalactosaminyltransferase 12 O -Glycan Golgi apparatus GT27, CBM13 Q8IUC8 Polypeptide N -acetylgalactosaminyltransferase 13 O -Glycan Golgi apparatus GT27, CBM13 Q96FL9 Polypeptide N -acetylgalactosaminyltransferase 14 O -Glycan Golgi apparatus GT27, CBM13 Q49A17 Polypeptide N -acetylgalactosaminyltransferase-like 6 O -Glycan Golgi apparatus GT27, CBM13 Q8N3T1 Polypeptide N -acetylgalactosaminyltransferase-like protein 2 O -Glycan Golgi apparatus GT27, CBM13 Q9NY28 Probable polypeptide N -acetylgalactosaminyltransferase 8 O -Glycan Golgi apparatus GT27, CBM13 Q8N428 Putative polypeptide N -acetylgalactosaminyltransferase-like protein 1 O -Glycan Golgi apparatus GT27, CBM13 Q6IS24 Putative polypeptide N -acetylgalactosaminyltransferase-like protein 3 O -Glycan Golgi apparatus GT27, CBM13 Q6P9A2 Putative polypeptide N -acetylgalactosaminyltransferase-like protein 4 O -Glycan Golgi apparatus GT27, CBM13 Q6Y288 -1,3-glucosyltransferase O -Glycan Endoplasmic reticulum GT31 Q9Y5Z6 -1,3-galactosyltransferase 1 Glycosphingolipid Golgi apparatus GT31 O43825 -1,3-galactosyltransferase 2 Glycosphingolipid Golgi apparatus GT31 O96024 -1,3-galactosyltransferase 4 O -Glycan, Glycosphingolipid Golgi apparatus GT31 Q96L58 -1,3-galactosyltransferase 6 Proteoglycan Golgi apparatus GT31 Q8NES3 -1,3-N -acetylglucosaminyltransferase lunatic fringe O -Glycan Golgi apparatus GT31 O00587 -1,3-N -acetylglucosaminyltransferase manic fringe O -Glycan Golgi apparatus GT31 Q9Y644 -1,3-N -acetylglucosaminyltransferase radical fringe O -Glycan Golgi apparatus GT31 Q96EU7 C1GALT1-specific chaperone 1 O -Glycan Golgi apparatus GT31 Q9NS00 Glycoprotein-N -acetylgalactosamine 3--galactosyltransferase 1 O -Glycan Golgi apparatus GT31 Q9BYG0 Lactosylceramide 1,3-N -acetyl--D-glucosaminyltransferase Glycosphingolipid Golgi apparatus GT31 O75752 UDP-GalNAc:-1,3-N -acetylgalactosaminyltransferase 1 Glycosphingolipid Golgi apparatus GT31 Q8NCR0 UDP-GalNAc:-1,3-N -acetylgalactosaminyltransferase 2 O -Glycan, N -Glycan Golgi apparatus GT31 Q9NY97 UDP-GlcNAc:Gal -1,3-N -acetylglucosaminyltransferase 2 Glycosphingolipid, Proteoglycan Golgi apparatus GT31 Q9Y2A9 UDP-GlcNAc:Gal -1,3-N -acetylglucosaminyltransferase 3 Glycosphingolipid Golgi apparatus GT31 Q9C0J1 UDP-GlcNAc:Gal -1,3-N -acetylglucosaminyltransferase 4 Glycosphingolipid Golgi apparatus GT31 Q6ZMB0 UDP-GlcNAc:Gal -1,3-N -acetylglucosaminyltransferase 6 O -Glycan Golgi apparatus GT31 Q8NFL0 UDP-GlcNAc:Gal -1,3-N -acetylglucosaminyltransferase 7 Proteoglycan Golgi apparatus GT31 Q7Z7M8 UDP-GlcNAc:Gal -1,3-N -acetylglucosaminyltransferase 8 N -Glycan Golgi apparatus GT31 Q9Y2C3 -1,3-galactosyltransferase 5 Glycosphingolipid Golgi apparatus+Endoplasmic reticulum GT31 Q9P2W7 Galactosylgalactosylxylosylprotein 3--glucuronosyltransferase 1 O -Glycan Golgi apparatus GT43 Q9NPZ5 Galactosylgalactosylxylosylprotein 3--glucuronosyltransferase 2 O -Glycan Golgi apparatus GT43 O94766 Galactosylgalactosylxylosylprotein 3--glucuronosyltransferase 3 Proteoglycan Golgi apparatus GT43 Q92935 Exostosin-like 1 Proteoglycan Endoplasmic reticulum GT47, GT64 O43909 Exostosin-like 3 Proteoglycan Endoplasmic reticulum GT47, GT64 Q16394 Exostosin-1 Proteoglycan Golgi apparatus+Endoplasmic reticulum GT47, GT64 Q93063 Exostosin-2 Proteoglycan Golgi apparatus+Endoplasmic reticulum GT47, GT64 O43505 N -acetyllactosaminide -1,3-N -acetylglucosaminyltransferase Glycosphingolipid, Proteoglycan Golgi apparatus GT49 O95461 Glycosyltransferase-like protein LARGE1 O -Glycan Golgi apparatus GT49, GT8 Q8N3Y3 Glycosyltransferase-like protein LARGE2 O -Glycan Golgi apparatus GT49, GT8 Q9UM21 -1,3-mannosyl-glycoprotein 4--N -acetylglucosaminyltransferase A N -Glycan Golgi apparatus GT54 Q9UQ53 -1,3-mannosyl-glycoprotein 4--N -acetylglucosaminyltransferase B N -Glycan Golgi apparatus GT54 Q9UBM8 -1,3-mannosyl-glycoprotein 4--N -acetylglucosaminyltransferase C N -Glycan Golgi apparatus GT54 Q5NDL2 EGF domain-specific O -linked N -acetylglucosamine transferase O -Glycan Endoplasmic reticulum GT61 Q9UBQ6 Exostosin-like 2 Proteoglycan Endoplasmic reticulum GT64 Q9H488 GDP-fucose protein O -fucosyltransferase 1 O -Glycan Endoplasmic reticulum GT65 Q9Y2G5 GDP-fucose protein O -fucosyltransferase 2 O -Glycan Golgi apparatus+Endoplasmic reticulum GT68 O60568 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 O -Glycan Endoplasmic reticulum - Q9P2E5 Chondroitin sulfate glucuronyltransferase Proteoglycan Golgi apparatus - Tomono et al.: Glycan evolution based on phylogenetic profiling 4

Supplementary Table S1. List of 173 enzymes that are composed of glycosyltransferases and functionally-linked glycan synthetic enzymes UniProt ID Protein Name Categories of Glycan Localization CAZy Class 3 Q9NP73 UDP-N -acetylglucosamine transferase subunit ALG13 homolog N -Glycan Endoplasmic reticulum GT1 Q96F25 UDP-N -acetylglucosamine transferase subunit ALG14 homolog N -Glycan Endoplasmic reticulum GT1 Q9H553 -1,3/1,6-mannosyltransferase ALG2 N -Glycan Endoplasmic reticulum GT4 Q2TAA5 GDP-Man:Man(3)GlcNAc(2)-PP-Dol -1,2-mannosyltransferase N -Glycan Endoplasmic reticulum GT4 Q16739 Ceramide glucosyltransferase Glycosphingolipid Golgi apparatus GT21 Q9H6U8 -1,2-mannosyltransferase ALG9 N -Glycan Endoplasmic reticulum GT22 Q9BV10 Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol -1,6-mannosyltransferase N -Glycan Endoplasmic reticulum GT22 Q92521 GPI mannosyltransferase 3 GPI anchor Endoplasmic reticulum GT22 Q86VD9 GPI mannosyltransferase 4 GPI anchor Endoplasmic reticulum GT22 Q9NYU2 UDP-glucose:glycoprotein glucosyltransferase 1 N -Glycan Golgi apparatus+Endoplasmic reticulum GT24 Q9NYU1 UDP-glucose:glycoprotein glucosyltransferase 2 N -Glycan Golgi apparatus+Endoplasmic reticulum GT24 Q9BT22 Chitobiosyldiphosphodolichol b-mannosyltransferase N -Glycan Endoplasmic reticulum GT33 Q9Y6A1 Protein O -mannosyl-transferase 1 O -Glycan Endoplasmic reticulum GT39 Q9UKY4 Protein O -mannosyl-transferase 2 O -Glycan Endoplasmic reticulum GT39 Q9H3S5 GPI mannosyltransferase 1 GPI anchor Endoplasmic reticulum GT50 Q9Y672 Dolichyl pyrophosphate Man9GlcNAc2 -1,3-glucosyltransferase N -Glycan Endoplasmic reticulum GT57 Q9BVK2 Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 -1,3-glucosyltransferase N -Glycan Endoplasmic reticulum GT57 Q92685 Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol -1,3-mannosyltransferase N -Glycan Endoplasmic reticulum GT58 Q5BKT4 Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol -1,2-glucosyltransferase N -Glycan Endoplasmic reticulum GT59 P46977 Dolichyl-diphosphooligosaccharideprotein glycosyltransferase subunit STT3A N -Glycan Endoplasmic reticulum GT66 Q8TCJ2 Dolichyl-diphosphooligosaccharideprotein glycosyltransferase subunit STT3B N -Glycan Endoplasmic reticulum GT66 Q9NUD9 GPI mannosyltransferase 2 GPI anchor Endoplasmic reticulum GT76 Q8NBL1 Protein O -glucosyltransferase 1 O-Glycan Endoplasmic reticulum GT90 P39656 Dolichyl-diphosphooligosaccharideprotein glycosyltransferase 48 kDa subunit N -Glycan Endoplasmic reticulum - P04843 Dolichyl-diphosphooligosaccharideprotein glycosyltransferase subunit 1 N -Glycan Endoplasmic reticulum - P04844 Dolichyl-diphosphooligosaccharideprotein glycosyltransferase subunit 2 N -Glycan Endoplasmic reticulum - P61803 Dolichyl-diphosphooligosaccharideprotein glycosyltransferase subunit DAD1 N -Glycan Endoplasmic reticulum - Q92535 Phosphatidylinositol N -acetylglucosaminyltransferase subunit C GPI anchor Endoplasmic reticulum - P57054 Phosphatidylinositol N -acetylglucosaminyltransferase subunit P GPI anchor Endoplasmic reticulum - Q9BRB3 Phosphatidylinositol N -acetylglucosaminyltransferase subunit Q GPI anchor Endoplasmic reticulum - Q13454 Tumor suppressor candidate 3 N -Glycan Endoplasmic reticulum - Q9H3H5 UDP-N-acetylglucosaminedolichyl-phosphate N -acetylglucosaminephosphotransferase N -Glycan Endoplasmic reticulum - Q5I7T1 Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol -1,2-glucosyltransferase N -Glycan Plasma membrane -

Class 4 O60762 Dolichol-phosphate mannosyltransferase N -Glycan Endoplasmic reticulum GT2 Q9Y673 Dolichyl-phosphate -glucosyltransferase N -Glycan Endoplasmic reticulum GT2 P37287 Phosphatidylinositol N -acetylglucosaminyltransferase subunit A GPI anchor Endoplasmic reticulum GT4 Mitochondria, Cytoplasm, Nucleus, Plasma O15294 UDP-N -acetylglucosaminepeptide N -acetylglucosaminyltransferase 110 kDa subunit O -Glycan GT41 membrane

Functionally-linked glycan synthetic enzymes were not labeled with a CAZy family description in the CAZy database, although they have been annotated as enzymes with glycosyltransferase activity. Class numbers show the classification of the enzymes by clustering analysis using phylogenetic profile of 1,353 species. Categories of glycan have been defined with reference to the KEGG database, and the cellular localization was from the UniProt database annotation. Protein names were expressed as "recommended names" or "alternative short names" in the UniProt database. The enzymes were divided into 4 sections in accordance with classes, and sorted in order of CAZy classification, localization, and protein name, each in turn.