Value Cluster LEFTY1 2.690865644 0.899 0.067 0.00E+00 C1

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Supplementary Table 3. Marker genes in each malignant epithelial cells cluster Gene Log(Fold-change) Pct.1 Pct.2 Adj p- value Cluster LEFTY1 2.690865644 0.899 0.067 0.00E+00 C1 TFF2 2.186713379 0.855 0.36 0.00E+00 C1 CCT2 1.701377329 0.801 0.283 0.00E+00 C1 SPINK4 1.663911876 0.654 0.128 0.00E+00 C1 TFF3 1.632604627 0.882 0.43 0.00E+00 C1 CXCL17 1.616238928 0.659 0.079 0.00E+00 C1 LDHB 1.407263152 0.711 0.137 0.00E+00 C1 CLDN18 1.398880496 0.825 0.278 0.00E+00 C1 TESC 1.382790712 0.79 0.212 0.00E+00 C1 PDIA6 1.295630983 0.789 0.404 0.00E+00 C1 PSCA 1.263596359 0.922 0.241 0.00E+00 C1 SRD5A3 1.246561606 0.586 0.098 0.00E+00 C1 PDIA4 1.180717046 0.849 0.419 0.00E+00 C1 DPCR1 1.175754587 0.506 0.06 0.00E+00 C1 WBP5 1.163957541 0.734 0.106 0.00E+00 C1 LYZ 1.141614179 0.969 0.727 0.00E+00 C1 RAP1B 1.125989315 0.68 0.255 0.00E+00 C1 S100P 1.055862172 0.962 0.758 0.00E+00 C1 OS9 1.05478066 0.787 0.338 0.00E+00 C1 R3HDM2 1.031695733 0.742 0.167 0.00E+00 C1 B3GNT7 1.031632795 0.549 0.088 0.00E+00 C1 MORF4L1 1.023176967 0.768 0.409 0.00E+00 C1 TMEM165 0.999912261 0.649 0.196 0.00E+00 C1 GALNT3 0.995165397 0.705 0.254 0.00E+00 C1 TFF1 0.962929536 0.96 0.591 0.00E+00 C1 LY6D 0.94328396 0.484 0.007 0.00E+00 C1 MIA 0.895355862 0.623 0.103 0.00E+00 C1 MDM2 0.864864363 0.615 0.089 0.00E+00 C1 YEATS4 0.864197638 0.585 0.128 0.00E+00 C1 CPM 0.831257805 0.511 0.026 0.00E+00 C1 NGFRAP1 0.776686405 0.552 0.027 0.00E+00 C1 TCEAL8 0.747773737 0.549 0.064 0.00E+00 C1 SFTA2 0.710176136 0.52 0.066 0.00E+00 C1 FKBP10 0.567908872 0.427 0.007 0.00E+00 C1 HOXB2 0.52009395 0.466 0.03 0.00E+00 C1 ALDH1L1 0.478075328 0.386 0.009 0.00E+00 C1 BCAR4 0.405445074 0.384 0 0.00E+00 C1 YWHAE 0.941441648 0.797 0.453 6.63E-301 C1 MUC5B 0.749504079 0.441 0.032 9.41E-296 C1 PKM 1.024781554 0.835 0.518 4.67E-293 C1 ATP1B1 1.094054311 0.838 0.514 5.73E-290 C1 PRKCDBP 0.521875888 0.445 0.04 1.78E-288 C1 PTP4A2 1.006611051 0.74 0.358 1.11E-281 C1 RAB34 0.379470725 0.394 0.022 1.26E-279 C1 C1QBP 1.055652495 0.699 0.29 1.74E-277 C1 AGR2 1.043123785 0.967 0.832 7.02E-277 C1

Zhang M, et al. Gut 2021; 70:1–12. doi: 10.1136/gutjnl-2019-320368 BMJ Publishing Group Limited (BMJ) disclaims all liability and responsibility arising from any reliance Supplemental material placed on this supplemental material which has been supplied by the author(s) Gut

VSIG1 0.728079807 0.537 0.093 8.17E-275 C1 NUP107 0.744204709 0.569 0.123 2.00E-274 C1 REG4 1.083913316 0.905 0.499 1.30E-270 C1 RP11-10A14.5 0.297216094 0.321 0 2.05E-269 C1 PTPLAD1 0.947636123 0.666 0.255 8.18E-269 C1 KRT17 0.903244887 0.401 0.03 1.67E-268 C1 DSTN 0.854726665 0.853 0.613 3.41E-268 C1 GALNT7 0.709216869 0.631 0.165 7.55E-268 C1 TFPI 0.753551093 0.647 0.186 1.34E-262 C1 HSP90AB1 0.844714478 0.922 0.665 7.40E-262 C1 SRSF9 0.978838275 0.658 0.282 6.15E-261 C1 GPR110 0.792021592 0.397 0.033 1.05E-256 C1 YWHAQ 0.917645011 0.684 0.318 3.66E-256 C1 SCGB2A1 0.350719764 0.323 0.005 1.20E-255 C1 DCTN2 0.855691592 0.617 0.219 2.39E-255 C1 CDK4 0.96724454 0.603 0.204 5.51E-255 C1 BEX2 0.312185722 0.323 0.006 1.10E-252 C1 ZFAND6 0.859643177 0.62 0.228 7.87E-251 C1 HSP90B1 0.894697739 0.881 0.592 7.89E-251 C1 RP11-2E17.1 0.333995995 0.3 0 1.03E-250 C1 CSTB 1.133047426 0.85 0.649 1.19E-248 C1 ULBP2 0.349850496 0.325 0.009 4.54E-247 C1 PUM1 0.730101664 0.655 0.226 1.47E-245 C1 CLIC1 1.06446547 0.835 0.65 1.46E-244 C1 BACE2 0.776146486 0.629 0.21 1.42E-242 C1 ANXA5 0.701165432 0.568 0.159 9.35E-239 C1 ZFC3H1 0.677887382 0.611 0.17 8.10E-234 C1 MAL2 0.952741646 0.742 0.397 1.27E-233 C1 MBD6 0.504246192 0.497 0.097 3.90E-231 C1 RBM47 0.886709293 0.705 0.357 5.12E-229 C1 TUBB 0.948856295 0.719 0.338 1.85E-228 C1 RAB3IP 0.740840685 0.566 0.161 5.86E-226 C1 SMC5 0.620713614 0.591 0.179 4.29E-224 C1 PIP4K2C 0.444414038 0.423 0.064 6.67E-223 C1 SLC35E3 0.422166937 0.392 0.05 3.86E-221 C1 ARL14 1.302472547 0.738 0.367 1.90E-220 C1 ANXA10 0.781303497 0.751 0.311 4.97E-220 C1 FRS2 0.36581964 0.368 0.039 5.55E-219 C1 SERINC2 0.751146496 0.785 0.471 1.10E-218 C1 HMGA1 0.836465129 0.781 0.485 1.33E-218 C1 C8orf4 0.869162861 0.726 0.288 7.08E-215 C1 RP11-519G16.5 0.275871768 0.278 0.005 2.19E-214 C1 FDFT1 0.88076215 0.625 0.257 6.92E-212 C1 TMED2 0.851218937 0.676 0.347 6.88E-210 C1 KRT19 0.82881006 0.969 0.874 4.18E-209 C1 CHMP1B 0.767154492 0.692 0.311 8.40E-209 C1 MTDH 0.719515427 0.792 0.488 4.07E-208 C1 RAB32 0.275438262 0.344 0.032 1.08E-204 C1

RAB21 0.481720994 0.478 0.11 8.39E-204 C1 CAP1 0.845841827 0.641 0.316 3.80E-203 C1 MYL12A 0.947954026 0.817 0.649 7.09E-203 C1 SDCBP 0.777669854 0.685 0.346 1.33E-202 C1 STARD10 0.733799598 0.854 0.536 1.36E-202 C1 SRP9 0.782786299 0.677 0.355 4.62E-202 C1 AHR 0.538273196 0.573 0.167 5.71E-202 C1 AKIRIN1 0.47764806 0.499 0.126 1.29E-201 C1 PDIA3 0.795061975 0.766 0.484 2.87E-197 C1 AKAP13 0.749638262 0.693 0.319 4.44E-197 C1 DST 0.680727101 0.706 0.282 5.07E-197 C1 TSPAN31 0.445008926 0.459 0.103 4.70E-196 C1 ANXA1 0.990611597 0.623 0.236 2.26E-195 C1 ANXA2 0.923005092 0.867 0.733 1.09E-194 C1 TFPT 0.433556663 0.492 0.12 3.67E-194 C1 SYNE4 0.276709421 0.295 0.018 5.91E-194 C1 PABPC1 0.58828564 0.933 0.752 9.95E-194 C1 MGST1 0.72142683 0.648 0.274 3.87E-193 C1 HIST1H2BK 0.845917465 0.665 0.342 6.48E-193 C1 MAGED1 0.397100639 0.427 0.082 1.45E-192 C1 CRK 0.526217931 0.559 0.178 2.04E-192 C1 TSPAN3 0.754095483 0.776 0.493 1.67E-191 C1 AGAP2 0.324034798 0.251 0.005 1.72E-191 C1 ARMCX3 0.393037375 0.435 0.087 9.19E-191 C1 MARS 0.507454194 0.464 0.107 1.66E-190 C1 RAN 0.831480759 0.747 0.465 1.81E-190 C1 ECI2 0.572148619 0.455 0.112 3.03E-190 C1 RHBDL2 0.416071426 0.456 0.102 9.05E-190 C1 HSPA5 0.813668975 0.775 0.442 5.45E-189 C1 ICAM2 0.282680792 0.283 0.017 1.47E-188 C1 CTSE 0.630732705 0.717 0.316 1.78E-187 C1 ZNF430 0.427332087 0.379 0.063 2.47E-187 C1 TM4SF1 1.0672273 0.705 0.377 4.05E-187 C1 VAPA 0.771645976 0.65 0.343 1.27E-186 C1 RCAN1 0.635068931 0.409 0.077 5.09E-186 C1 FRMD4B 0.610702297 0.43 0.092 1.65E-185 C1 DDIT3 0.796008573 0.606 0.219 1.93E-185 C1 PRPF4B 0.740129307 0.815 0.408 7.56E-184 C1 ABCF1 0.663423185 0.722 0.338 8.01E-184 C1 LDLR 0.774135152 0.71 0.337 2.04E-183 C1 TSPAN13 0.69173611 0.603 0.26 3.34E-183 C1 ACTR2 0.644131887 0.651 0.298 1.18E-182 C1 RAB11FIP1 0.797810148 0.766 0.437 3.38E-181 C1 NDUFV2 0.780467632 0.671 0.38 5.18E-180 C1 KRT7 0.686045312 0.698 0.306 1.03E-179 C1 NMB 0.452105539 0.428 0.099 1.55E-179 C1 SQLE 0.820767424 0.628 0.258 1.61E-179 C1 ADAM17 0.421792244 0.455 0.111 2.05E-178 C1

DUSP4 0.448374151 0.468 0.116 3.14E-178 C1 MLF1 0.326425154 0.333 0.044 6.16E-178 C1 IL1R2 0.438702039 0.379 0.062 8.72E-178 C1 KLF5 0.715777433 0.715 0.396 2.02E-177 C1 UBC 0.67976553 0.953 0.873 6.37E-177 C1 TIMP1 0.637993444 0.653 0.276 7.90E-177 C1 RBPMS 0.307079432 0.36 0.056 1.31E-176 C1 SELK 0.716351523 0.716 0.421 1.94E-174 C1 CLIC6 0.265867931 0.253 0.013 3.95E-172 C1 HEBP2 0.631908603 0.714 0.393 1.12E-170 C1 GCNT2 0.470513382 0.397 0.077 1.25E-170 C1 YBX3 0.612916652 0.68 0.321 1.93E-170 C1 RHOF 0.538126719 0.545 0.174 4.40E-170 C1 RTN4 0.675104425 0.674 0.356 1.09E-169 C1 IDH1 0.634194486 0.658 0.307 1.46E-168 C1 LRRFIP1 0.661080293 0.735 0.423 1.88E-168 C1 PRKCI 0.465440765 0.467 0.133 5.45E-168 C1 RAP2B 0.546435477 0.553 0.186 1.27E-167 C1 REL 0.701246107 0.58 0.228 5.11E-167 C1 ACBD3 0.4514312 0.514 0.165 3.34E-166 C1 SLC17A9 0.474566396 0.39 0.075 1.53E-165 C1 PMEPA1 0.527426407 0.434 0.108 3.38E-164 C1 UGCG 0.527086143 0.488 0.15 4.69E-164 C1 AZGP1 0.422761604 0.493 0.14 1.16E-163 C1 SCD 0.650939626 0.483 0.149 2.22E-163 C1 UBE2E3 0.521908254 0.539 0.207 3.75E-163 C1 HOXB4 0.30709314 0.272 0.024 1.30E-162 C1 RRBP1 0.686783971 0.946 0.727 1.57E-162 C1 TPD52L1 0.260478907 0.32 0.043 2.48E-162 C1 MYO1C 0.520844479 0.586 0.208 7.82E-162 C1 C12orf75 0.841641896 0.679 0.38 8.18E-162 C1 GSPT1 0.526616852 0.582 0.242 2.10E-160 C1 ABHD17C 0.538738634 0.537 0.192 3.86E-158 C1 ACSL3 0.406750671 0.478 0.145 1.31E-157 C1 GPRC5A 0.755154359 0.7 0.399 8.02E-157 C1 PFN1 0.756852374 0.864 0.788 1.42E-156 C1 LMNA 0.583815958 0.875 0.669 1.57E-156 C1 HNRNPA3 0.621559821 0.769 0.492 3.64E-156 C1 MCL1 0.806820459 0.701 0.425 4.21E-156 C1 WHAMM 0.349313728 0.379 0.079 1.98E-154 C1 SRPK1 0.530525058 0.572 0.242 2.08E-154 C1 RDH11 0.449706655 0.477 0.147 2.79E-154 C1 USP14 0.383828842 0.45 0.128 4.05E-154 C1 TMEM66 0.621665665 0.623 0.308 7.54E-154 C1 CREB3L1 0.503452513 0.517 0.182 7.78E-154 C1 ENAH 0.419839954 0.47 0.14 7.10E-153 C1 EIF3I 0.689146404 0.646 0.363 1.72E-152 C1 C4BPB 0.313614512 0.34 0.061 2.55E-152 C1

MSMO1 0.549774328 0.438 0.126 6.18E-152 C1 MTHFS 0.497024114 0.53 0.199 1.60E-151 C1 ONECUT2 0.516705811 0.541 0.186 5.10E-151 C1 ADAM9 0.398395405 0.504 0.162 5.56E-151 C1 YES1 0.357407104 0.419 0.11 2.35E-150 C1 PPIB 0.666987429 0.759 0.528 2.95E-150 C1 KIAA1430 0.40896522 0.44 0.122 3.39E-150 C1 SKIL 0.453436868 0.519 0.173 3.92E-150 C1 SDC4 0.721646347 0.69 0.366 1.32E-149 C1 TAOK3 0.556422202 0.693 0.339 1.60E-149 C1 TMED3 0.575936005 0.656 0.346 2.18E-148 C1 RNMT 0.540847513 0.654 0.288 2.33E-148 C1 GPX1 0.610892166 0.752 0.533 2.10E-147 C1 SNRPD1 0.665510024 0.712 0.423 2.93E-147 C1 LIMS1 0.370651297 0.454 0.137 6.70E-147 C1 MORF4L2 0.577776357 0.669 0.375 6.85E-147 C1 CT83 0.275229979 0.332 0.06 5.72E-146 C1 TRIAP1 0.437387336 0.451 0.146 8.85E-146 C1 TMC5 0.680777499 0.858 0.636 1.06E-144 C1 KCNK1 0.496136968 0.491 0.172 4.60E-144 C1 B4GALT1 0.532747586 0.484 0.163 5.25E-144 C1 NOL10 0.318819379 0.378 0.094 1.20E-143 C1 TJP1 0.47440642 0.519 0.189 1.44E-143 C1 RAB11A 0.617191883 0.661 0.39 1.71E-143 C1 CHD3 0.517524559 0.439 0.124 5.62E-143 C1 AFG3L2 0.481910967 0.558 0.214 8.72E-143 C1 ZCCHC17 0.380067623 0.455 0.149 2.20E-142 C1 THRAP3 0.503278519 0.61 0.276 2.62E-142 C1 RAB1A 0.587667295 0.645 0.358 1.14E-141 C1 FAM103A1 0.380464791 0.475 0.162 1.15E-141 C1 PSMB6 0.664861403 0.64 0.384 1.87E-141 C1 TJP2 0.54045939 0.579 0.246 2.26E-141 C1 IAH1 0.410177285 0.482 0.17 2.53E-141 C1 DNAJA1 0.584293486 0.682 0.388 3.21E-141 C1 TBC1D15 0.318231185 0.382 0.094 7.96E-141 C1 CLOCK 0.313171162 0.353 0.074 2.72E-140 C1 ARF6 0.540587889 0.586 0.261 6.36E-140 C1 TPM4 0.585221901 0.684 0.387 8.77E-140 C1 CA9 0.331351757 0.318 0.057 2.04E-139 C1 KRAS 0.423469378 0.49 0.175 7.09E-139 C1 HDLBP 0.587212207 0.72 0.408 2.37E-138 C1 SLC44A4 0.53841148 0.762 0.452 6.94E-138 C1 METTL1 0.373822919 0.364 0.087 1.21E-137 C1 HSD17B12 0.47718659 0.554 0.235 1.59E-137 C1 RHOA 0.56139513 0.734 0.492 2.56E-137 C1 MSMB 0.535467016 0.458 0.138 3.36E-137 C1 MRPS15 0.523817684 0.603 0.299 4.36E-137 C1 SUCLG2 0.533447669 0.588 0.286 2.04E-136 C1

NDUFV3 0.473401886 0.627 0.303 2.37E-136 C1 MAGED2 0.298086218 0.381 0.096 3.16E-136 C1 MRPS18B 0.460518273 0.551 0.231 9.05E-136 C1 SNRNP40 0.402353576 0.435 0.142 9.39E-136 C1 MAPK6 0.394355852 0.51 0.181 1.75E-135 C1 SNAP23 0.375151258 0.456 0.151 1.81E-135 C1 RALBP1 0.535910442 0.661 0.335 3.37E-135 C1 ROCK1 0.400659168 0.524 0.195 3.91E-135 C1 PI3 0.443705832 0.442 0.128 1.19E-134 C1 PAFAH1B1 0.346104873 0.474 0.158 1.26E-134 C1 RPL36AL 0.522685381 0.851 0.772 4.91E-134 C1 OCIAD2 0.765184948 0.64 0.415 1.31E-133 C1 EFNB2 0.386641173 0.417 0.115 1.33E-133 C1 GFPT1 0.502844669 0.58 0.255 5.08E-132 C1 PTPRK 0.425845035 0.55 0.222 8.40E-132 C1 RIOK3 0.446244287 0.58 0.24 9.25E-132 C1 DAG1 0.412499894 0.464 0.157 1.69E-131 C1 C1GALT1 0.387646316 0.503 0.187 3.63E-131 C1 TNFAIP3 0.759097606 0.439 0.152 4.04E-131 C1 PRRC2C 0.565236553 0.805 0.499 4.68E-131 C1 SH3KBP1 0.339651622 0.447 0.142 5.40E-131 C1 HIST1H1C 0.6331583 0.659 0.328 6.54E-131 C1 SRP72 0.50027758 0.517 0.224 7.64E-131 C1 GLOD4 0.413492486 0.498 0.195 1.92E-130 C1 PLS3 0.293460863 0.359 0.088 5.05E-130 C1 DACH1 0.272274795 0.302 0.055 6.57E-130 C1 IER3 0.768907201 0.766 0.481 9.15E-130 C1 RSRC2 0.521802118 0.68 0.362 9.54E-130 C1 ZMPSTE24 0.331097972 0.417 0.13 1.39E-129 C1 PLIN3 0.420854398 0.503 0.193 3.35E-129 C1 EID1 0.444716124 0.527 0.216 8.77E-129 C1 TRIM27 0.360906409 0.426 0.13 1.27E-128 C1 DENR 0.451125651 0.54 0.233 1.69E-128 C1 RCN2 0.345188668 0.447 0.147 2.20E-128 C1 MYL12B 0.71475841 0.797 0.712 5.33E-128 C1 PTPN2 0.385298416 0.466 0.159 2.84E-127 C1 RCN3 0.276274349 0.299 0.054 5.98E-126 C1 CALR 0.57565338 0.805 0.592 8.22E-126 C1 MECOM 0.450448441 0.538 0.208 9.04E-126 C1 PSMB8 0.534185197 0.713 0.462 9.20E-126 C1 MESDC2 0.468614691 0.575 0.266 9.80E-126 C1 YBX1 0.707984129 0.78 0.634 1.18E-125 C1 FAM3D 0.582569394 0.699 0.404 1.20E-125 C1 IMPA2 0.384484941 0.426 0.139 4.20E-125 C1 ASAH1 0.451619521 0.534 0.234 4.30E-125 C1 IFITM2 0.390762212 0.509 0.197 5.35E-125 C1 KPNA6 0.388170234 0.439 0.146 7.81E-125 C1 ANKRD12 0.503254377 0.627 0.294 8.42E-125 C1

KRCC1 0.296376737 0.397 0.114 3.25E-124 C1 LSR 0.544942901 0.727 0.475 4.04E-124 C1 GSTT1 0.27533428 0.382 0.104 5.60E-124 C1 TBL1XR1 0.45020291 0.549 0.237 7.17E-124 C1 ALDOA 0.733497316 0.809 0.712 2.74E-123 C1 RPAIN 0.429115491 0.51 0.204 2.90E-123 C1 NCL 0.590393898 0.802 0.537 1.27E-122 C1 NAB1 0.252801422 0.33 0.075 4.26E-122 C1 PDXK 0.403281085 0.542 0.218 6.49E-122 C1 EIF5B 0.522829517 0.819 0.56 7.27E-122 C1 HEXA 0.357859786 0.478 0.171 7.90E-122 C1 ETFA 0.475774613 0.631 0.336 1.02E-121 C1 LEPREL4 0.287785099 0.296 0.056 1.67E-121 C1 TMEM30B 0.279697233 0.431 0.135 1.72E-121 C1 SLC39A7 0.420527158 0.554 0.241 4.61E-121 C1 ARHGAP18 0.333781986 0.435 0.144 8.78E-121 C1 FAM120A 0.496594344 0.635 0.327 1.33E-120 C1 HIST1H2AC 0.479676153 0.541 0.233 2.28E-120 C1 GNL2 0.350086226 0.433 0.144 2.39E-120 C1 APPL2 0.2513356 0.375 0.101 2.64E-120 C1 ZFP36L2 0.539316933 0.821 0.612 3.60E-120 C1 MRPL14 0.5281055 0.668 0.429 5.96E-120 C1 BZW1 0.44056314 0.569 0.263 1.22E-119 C1 TMSB4X 0.584780605 0.975 0.97 1.92E-119 C1 TM7SF3 0.326391197 0.426 0.141 1.94E-119 C1 NCOA7 0.684441969 0.596 0.313 2.02E-119 C1 HSP90AA1 0.596361548 0.862 0.669 4.01E-119 C1 EDEM3 0.371689008 0.473 0.168 4.36E-119 C1 SEPHS2 0.558743315 0.69 0.395 1.51E-118 C1 LPIN2 0.428968338 0.539 0.218 1.57E-118 C1 ARPC2 0.575360769 0.708 0.515 2.19E-118 C1 ANKLE2 0.421261904 0.49 0.183 4.35E-118 C1 SPTBN1 0.541563187 0.715 0.414 5.57E-118 C1 FAM114A1 0.28559889 0.374 0.102 7.99E-118 C1 PIM1 0.361286291 0.371 0.105 1.22E-117 C1 BBX 0.340637859 0.453 0.156 1.25E-117 C1 CEBPD 0.606504655 0.594 0.294 1.79E-117 C1 TINAGL1 0.45948247 0.579 0.267 2.10E-117 C1 GALNT5 0.285661613 0.311 0.066 2.19E-117 C1 CAPZA1 0.440163217 0.573 0.278 2.61E-117 C1 CCDC167 0.353926463 0.444 0.152 2.70E-117 C1 RAD23A 0.465793725 0.632 0.348 3.52E-117 C1 LIPH 0.589476532 0.734 0.438 5.24E-117 C1 RNASET2 0.748229684 0.623 0.366 5.98E-117 C1 CHIC2 0.257503487 0.363 0.1 1.72E-116 C1 CD55 0.66703993 0.613 0.316 1.84E-116 C1 CHMP5 0.513979674 0.575 0.301 2.04E-116 C1 RNF10 0.319477648 0.46 0.166 2.77E-116 C1

LINC00998 0.321875357 0.438 0.158 4.87E-116 C1 CXCL16 0.524555832 0.524 0.239 1.36E-115 C1 C9orf3 0.328787408 0.432 0.148 1.65E-115 C1 CKAP4 0.315671239 0.403 0.126 2.49E-115 C1 ITM2C 0.325521913 0.481 0.176 2.99E-115 C1 XBP1 0.498284004 0.683 0.401 3.40E-115 C1 PSMG1 0.275850761 0.355 0.1 4.27E-115 C1 ZG16B 0.521266875 0.45 0.161 5.14E-115 C1 CSDE1 0.465675453 0.604 0.323 8.10E-115 C1 ARPC3 0.685687909 0.657 0.479 1.37E-114 C1 NFKBIE 0.257347474 0.311 0.072 2.74E-114 C1 AP3D1 0.442232065 0.561 0.246 3.18E-114 C1 YOD1 0.309554595 0.324 0.079 7.44E-114 C1 KDELR2 0.548453329 0.689 0.462 1.73E-113 C1 COPB1 0.37146661 0.492 0.193 2.32E-113 C1 FTL 0.700802798 0.961 0.895 2.66E-113 C1 EIF5A 0.60291494 0.744 0.515 4.80E-113 C1 SLC35B3 0.256730253 0.384 0.114 7.46E-113 C1 TRIM2 0.388390482 0.518 0.218 9.13E-113 C1 ECHDC1 0.334897799 0.436 0.159 1.07E-112 C1 NAPG 0.254699818 0.379 0.111 2.23E-112 C1 SFPQ 0.499398643 0.676 0.382 8.65E-112 C1 TTC3 0.450869162 0.623 0.306 3.75E-111 C1 WDR45B 0.492951707 0.651 0.349 4.05E-111 C1 TXNRD1 0.429448106 0.505 0.211 4.25E-111 C1 FXN 0.309137494 0.384 0.126 8.67E-111 C1 HSPE1 0.526719787 0.841 0.647 1.23E-110 C1 COL27A1 0.637098247 0.435 0.157 1.28E-110 C1 XRCC5 0.477680766 0.567 0.292 1.44E-110 C1 ZBTB7A 0.466434249 0.633 0.309 3.57E-110 C1 INO80C 0.319855981 0.428 0.15 8.63E-110 C1 ARL5A 0.307620298 0.465 0.179 9.94E-110 C1 PSMG2 0.41838374 0.512 0.234 9.99E-110 C1 EIF1AX 0.459014867 0.647 0.37 1.39E-109 C1 CREB3 0.296982453 0.411 0.135 1.81E-109 C1 WDR46 0.371170069 0.448 0.166 1.92E-109 C1 CHPF 0.269399775 0.379 0.114 1.27E-108 C1 LITAF 0.332520121 0.47 0.18 1.30E-108 C1 TMEM120B 0.261449881 0.29 0.063 2.15E-108 C1 RBM42 0.396372304 0.532 0.244 3.59E-108 C1 CSNK2B 0.495810853 0.626 0.39 3.61E-108 C1 KLHL23 0.390208221 0.366 0.111 3.89E-108 C1 GOLGA3 0.303296324 0.375 0.111 4.00E-108 C1 TMF1 0.292334101 0.418 0.143 6.44E-108 C1 NUCB2 0.302071083 0.374 0.115 1.05E-107 C1 TNFRSF21 0.384802391 0.425 0.155 2.88E-107 C1 SRP14 0.433040531 0.833 0.721 3.42E-107 C1 ACAT2 0.372902575 0.359 0.112 6.07E-107 C1

HNRNPU 0.468324562 0.731 0.469 7.35E-107 C1 SON 0.478735216 0.88 0.654 3.72E-106 C1 ALDH3B1 0.261277209 0.326 0.085 3.78E-106 C1 PSMA4 0.631476514 0.627 0.405 4.19E-106 C1 LPIN1 0.349203231 0.369 0.112 1.03E-105 C1 DHRS7 0.352369107 0.491 0.203 1.23E-104 C1 GJB3 0.308612408 0.342 0.099 1.44E-104 C1 LGALS2 0.473193539 0.53 0.234 3.89E-104 C1 YWHAB 0.469216408 0.749 0.536 4.67E-104 C1 NELFE 0.395861878 0.569 0.278 7.22E-104 C1 TCEAL4 0.259663626 0.339 0.091 7.31E-104 C1 CDC5L 0.335686294 0.487 0.198 9.29E-104 C1 CD2AP 0.407639056 0.608 0.309 1.16E-103 C1 CIB1 0.497568389 0.717 0.549 1.55E-103 C1 PPARG 0.264585079 0.389 0.129 1.83E-103 C1 FOXP1 0.383442211 0.603 0.297 3.75E-103 C1 C12orf57 0.456072095 0.706 0.452 5.87E-103 C1 MRPS21 0.487349561 0.709 0.488 7.29E-103 C1 H3F3A 0.461151774 0.883 0.8 9.06E-103 C1 GCNT3 0.471075437 0.558 0.261 3.32E-102 C1 MLPH 0.395683181 0.604 0.284 3.80E-101 C1 DNAJC3 0.352973024 0.493 0.214 3.87E-101 C1 LAMC2 0.406092579 0.371 0.117 5.51E-101 C1 SEZ6L2 0.295639587 0.396 0.127 6.73E-101 C1 CLCN3 0.343175673 0.472 0.189 1.98E-100 C1 TMEM192 0.254494906 0.304 0.078 2.39E-100 C1 SPAG9 0.406794956 0.508 0.212 5.53E-100 C1 PPP1R15B 0.439515184 0.499 0.212 8.65E-100 C1 RBBP4 0.403351564 0.583 0.282 1.08E-99 C1 MANF 0.4187993 0.564 0.277 1.95E-99 C1 TMEM106B 0.298678139 0.413 0.15 2.99E-99 C1 SH3RF1 0.254289086 0.383 0.124 3.27E-99 C1 EMC6 0.332547767 0.464 0.2 3.86E-99 C1 NFIB 0.362037456 0.518 0.23 4.23E-99 C1 NEDD9 0.336403377 0.435 0.163 4.57E-99 C1 SET 0.446236112 0.767 0.501 5.13E-99 C1 ITGAV 0.27056724 0.339 0.098 5.47E-99 C1 CLIP1 0.292223604 0.405 0.14 6.06E-99 C1 SYAP1 0.405251109 0.574 0.299 1.52E-98 C1 SPAG7 0.355300697 0.502 0.228 2.23E-98 C1 TPM1 0.428992476 0.839 0.675 2.30E-98 C1 ZNF75A 0.278689248 0.274 0.062 5.47E-98 C1 SNX3 0.468544024 0.579 0.341 8.20E-98 C1 INSIG1 0.528739465 0.442 0.187 9.19E-98 C1 LSM12 0.309772505 0.46 0.19 1.23E-97 C1 ESCO1 0.259583256 0.354 0.106 1.33E-97 C1 COX6A1 0.499494361 0.794 0.717 4.91E-97 C1 MARCKSL1 0.539183834 0.675 0.458 6.42E-97 C1

TRIP6 0.378122503 0.509 0.236 9.68E-97 C1 EIF3J 0.484400854 0.825 0.566 2.57E-96 C1 PRPF40A 0.392191972 0.587 0.311 4.17E-96 C1 VPS37B 0.366760984 0.537 0.25 4.87E-96 C1 TMCO1 0.456561128 0.703 0.455 5.03E-96 C1 MAP3K13 0.465189331 0.609 0.35 6.98E-96 C1 ALDH2 0.549300713 0.595 0.38 1.68E-95 C1 GOLGB1 0.437977941 0.694 0.407 2.14E-95 C1 TRMT112 0.450423919 0.669 0.436 3.47E-95 C1 DDX18 0.458542147 0.677 0.397 4.60E-95 C1 SNRPC 0.408463591 0.531 0.275 3.42E-94 C1 HIF1A 0.293827024 0.381 0.132 3.71E-94 C1 KHDRBS1 0.37647458 0.572 0.293 4.01E-94 C1 ITM2B 0.516794496 0.745 0.598 4.31E-94 C1 GALK2 0.262511919 0.382 0.133 9.45E-94 C1 RIPK2 0.271111902 0.346 0.111 2.29E-93 C1 FLOT1 0.33089046 0.496 0.226 2.41E-93 C1 FXYD3 0.632719816 0.813 0.741 3.72E-93 C1 MRPL3 0.382347486 0.492 0.235 5.60E-93 C1 SLPI 0.355248513 0.565 0.272 6.87E-93 C1 MMADHC 0.368826821 0.484 0.227 6.93E-93 C1 COX6B1 0.32364377 0.926 0.874 7.10E-93 C1 ENOSF1 0.335974223 0.488 0.207 1.04E-92 C1 LAPTM4B 0.357980361 0.517 0.245 1.06E-92 C1 HDAC1 0.396930024 0.579 0.31 1.52E-92 C1 ANP32A 0.388055213 0.545 0.28 1.71E-92 C1 HLA-A 0.346102461 0.963 0.913 2.32E-92 C1 UBE2R2 0.26984292 0.432 0.172 2.58E-92 C1 CLTA 0.456969461 0.664 0.461 3.17E-92 C1 LRRC1 0.253152173 0.405 0.147 4.29E-92 C1 TMBIM1 0.436471986 0.623 0.353 5.76E-92 C1 ADSS 0.284933812 0.423 0.168 1.13E-91 C1 KARS 0.364610044 0.514 0.25 1.48E-91 C1 HNRNPK 0.437831649 0.744 0.516 2.42E-91 C1 HMGCS2 0.629744249 0.453 0.194 2.88E-91 C1 ARF1 0.424225272 0.737 0.494 3.77E-91 C1 ARL6IP5 0.387649374 0.55 0.284 4.68E-91 C1 FH 0.259751452 0.382 0.142 5.08E-91 C1 FOXO3 0.30970541 0.414 0.157 5.51E-91 C1 LMO4 0.424572091 0.617 0.312 6.01E-91 C1 RHOB 0.489849727 0.652 0.371 9.08E-91 C1 HNRNPH2 0.29764662 0.446 0.187 1.70E-90 C1 EIF2S1 0.290760235 0.422 0.171 2.39E-90 C1 ITGB8 0.304648835 0.283 0.073 3.98E-90 C1 RFK 0.320527976 0.447 0.192 4.33E-90 C1 MAP2K3 0.33050306 0.504 0.226 6.15E-90 C1 PGRMC1 0.387755312 0.56 0.29 6.70E-90 C1 SMARCC1 0.360992034 0.508 0.232 6.85E-90 C1

SAT1 0.638046633 0.925 0.828 1.39E-89 C1 44083 0.337151381 0.544 0.266 1.79E-89 C1 CSRP1 0.265093322 0.415 0.158 2.13E-89 C1 DHX15 0.318000312 0.488 0.217 3.07E-89 C1 HNRNPC 0.440949814 0.683 0.47 3.97E-89 C1 LSM2 0.3821482 0.473 0.231 4.01E-89 C1 ETNK1 0.323536073 0.572 0.285 4.37E-89 C1 WNK1 0.269621398 0.382 0.137 7.90E-89 C1 HSD17B2 0.335846986 0.505 0.225 8.54E-89 C1 DYNLT1 0.437052177 0.598 0.373 9.95E-89 C1 GCC2 0.413962092 0.64 0.362 1.46E-88 C1 THOC2 0.388411116 0.594 0.313 2.86E-88 C1 BRI3BP 0.397181017 0.454 0.198 5.44E-88 C1 GALNT1 0.256776905 0.381 0.133 6.76E-88 C1 GNPNAT1 0.27706089 0.392 0.149 7.87E-88 C1 NTPCR 0.261235427 0.392 0.15 1.58E-87 C1 ESYT2 0.267775118 0.361 0.126 1.76E-87 C1 EIF2S2 0.42391114 0.773 0.542 2.15E-87 C1 SSFA2 0.320381179 0.486 0.217 2.47E-87 C1 SNRPA1 0.376139771 0.506 0.25 2.57E-87 C1 SERPINH1 0.271273624 0.423 0.167 2.66E-87 C1 TAF11 0.282140533 0.455 0.19 5.15E-87 C1 CPSF6 0.310833672 0.431 0.178 5.23E-87 C1 EZR 0.439895287 0.777 0.592 1.18E-86 C1 GLO1 0.35808622 0.502 0.249 1.53E-86 C1 PRSS22 0.352382508 0.403 0.157 2.21E-86 C1 UQCC2 0.395151795 0.591 0.319 2.40E-86 C1 ACTG1 0.519140049 0.9 0.852 4.23E-86 C1 EBPL 0.312734604 0.473 0.205 9.80E-86 C1 TIPARP 0.277626547 0.439 0.183 1.44E-85 C1 MEAF6 0.314510177 0.475 0.215 1.81E-85 C1 NFKBIA 0.748396396 0.767 0.582 2.28E-85 C1 SMS 0.385762295 0.537 0.288 2.37E-85 C1 PSMA1 0.405776122 0.578 0.335 2.37E-85 C1 TMA16 0.344119402 0.485 0.22 2.43E-85 C1 GADD45GIP1 0.44797795 0.789 0.551 2.75E-85 C1 ARF4 0.455123102 0.595 0.38 3.76E-85 C1 SOD2 0.457085682 0.575 0.32 4.38E-85 C1 DNAJB6 0.39638394 0.578 0.319 5.55E-85 C1 PRRG4 0.264521927 0.347 0.116 5.99E-85 C1 EIF4A1 0.478270029 0.778 0.644 1.03E-84 C1 C11orf58 0.379735369 0.611 0.347 2.53E-84 C1 NUCKS1 0.504338129 0.696 0.437 3.41E-84 C1 PSMD7 0.426018665 0.581 0.339 4.39E-84 C1 GIPC1 0.337520703 0.522 0.261 6.18E-84 C1 COPB2 0.297750782 0.478 0.22 6.32E-84 C1 HLA-E 0.445217899 0.811 0.653 6.57E-84 C1 PTTG1IP 0.347130676 0.545 0.275 2.27E-83 C1

LGALS4 0.750779613 0.839 0.802 2.44E-83 C1 AHSA1 0.3436009 0.485 0.234 2.90E-83 C1 SMARCA5 0.254273239 0.406 0.161 3.57E-83 C1 CTSH 0.410233928 0.552 0.305 8.78E-83 C1 TGIF1 0.385703663 0.514 0.256 9.15E-83 C1 VPS29 0.416598839 0.569 0.334 1.03E-82 C1 SFT2D1 0.396136063 0.536 0.302 1.20E-82 C1 CDC42BPA 0.292669514 0.528 0.242 1.32E-82 C1 KRT10 0.333126838 0.552 0.278 2.86E-82 C1 PRDX1 0.409922695 0.779 0.596 3.66E-82 C1 WEE1 0.295037607 0.403 0.159 3.96E-82 C1 SOX9 0.404494926 0.558 0.29 4.16E-82 C1 LGALS3BP 0.330522109 0.876 0.701 4.24E-82 C1 SLC43A1 0.318718116 0.373 0.14 3.19E-81 C1 CNOT7 0.253312482 0.43 0.18 4.36E-81 C1 MZT2B 0.415020404 0.725 0.518 1.30E-80 C1 PPCS 0.336081393 0.532 0.284 1.41E-80 C1 PSMA5 0.419205549 0.537 0.31 1.72E-80 C1 ARID4B 0.333372741 0.549 0.277 2.38E-80 C1 ANAPC5 0.310148909 0.501 0.244 4.26E-80 C1 DARS 0.287640525 0.463 0.216 4.49E-80 C1 SSB 0.311210207 0.602 0.324 5.71E-80 C1 CCT3 0.419468723 0.623 0.386 1.37E-79 C1 RAD21 0.375068638 0.573 0.299 2.10E-79 C1 SPR 0.251746291 0.438 0.183 2.66E-79 C1 EHF 0.278778075 0.476 0.218 3.18E-79 C1 MIDN 0.421812607 0.612 0.345 3.26E-79 C1 PERP 0.476866692 0.672 0.509 4.44E-79 C1 ZBTB43 0.32257658 0.402 0.166 7.47E-79 C1 COTL1 0.381186901 0.576 0.332 1.19E-78 C1 TAF7 0.372834142 0.602 0.328 1.73E-78 C1 TACSTD2 0.564088437 0.627 0.394 2.53E-78 C1 PSMB5 0.417422153 0.525 0.297 2.71E-78 C1 LRRC59 0.317918892 0.515 0.269 4.20E-78 C1 RAB2A 0.390680495 0.653 0.422 5.07E-78 C1 ANP32E 0.33150136 0.431 0.186 5.80E-78 C1 BHLHE41 0.260841417 0.342 0.121 8.90E-78 C1 HRSP12 0.258539214 0.434 0.194 9.35E-78 C1 FABP5 0.40662257 0.589 0.34 1.01E-77 C1 PLAC8 0.426222289 0.576 0.315 1.54E-77 C1 NFE2L2 0.351424743 0.596 0.335 2.28E-77 C1 UTP11L 0.282501205 0.406 0.173 2.29E-77 C1 MRPS11 0.280859148 0.479 0.231 2.45E-77 C1 PSMD14 0.313213335 0.54 0.282 3.06E-77 C1 DSG2 0.328449367 0.601 0.32 3.13E-77 C1 YIPF4 0.325319553 0.507 0.253 3.41E-77 C1 HMGN1 0.385741423 0.774 0.578 3.58E-77 C1 BRD2 0.368234488 0.687 0.42 3.60E-77 C1

TFG 0.346626446 0.54 0.302 4.24E-77 C1 ACTR3 0.319211099 0.541 0.294 4.55E-77 C1 SF3B2 0.367719526 0.633 0.38 4.74E-77 C1 CHD2 0.36453728 0.556 0.286 5.66E-77 C1 HSPD1 0.419680843 0.679 0.443 1.82E-76 C1 GNL3 0.386242581 0.595 0.337 2.34E-76 C1 EIF4E2 0.284715351 0.491 0.25 2.70E-76 C1 FUT6 0.323529962 0.314 0.103 3.06E-76 C1 CTSS 0.396687921 0.638 0.396 5.00E-76 C1 TOR1AIP2 0.280351329 0.48 0.223 1.35E-75 C1 LAMA3 0.381260476 0.392 0.156 1.39E-75 C1 MRPS35 0.346938246 0.497 0.262 1.44E-75 C1 PLEKHA5 0.265240709 0.432 0.18 2.10E-75 C1 GTF2H5 0.293806613 0.498 0.253 4.06E-75 C1 STAU1 0.278946116 0.514 0.263 5.90E-75 C1 TCP1 0.339287265 0.506 0.268 8.91E-75 C1 PRDX2 0.358898007 0.67 0.425 9.73E-75 C1 CCDC57 0.263603296 0.413 0.169 9.76E-75 C1 FXYD5 0.344436685 0.532 0.273 9.90E-75 C1 CXCL1 0.650670363 0.459 0.221 1.12E-74 C1 EIF3M 0.360943486 0.529 0.294 1.22E-74 C1 SH3YL1 0.347261014 0.538 0.304 1.66E-74 C1 IL8 0.812504337 0.388 0.171 1.97E-74 C1 GTF3C6 0.328289539 0.511 0.271 2.37E-74 C1 TMEM147 0.378106508 0.576 0.344 4.98E-74 C1 LARP1B 0.326019238 0.442 0.196 8.40E-74 C1 DDR1 0.326488822 0.543 0.279 8.91E-74 C1 PLAUR 0.563273026 0.535 0.287 2.68E-73 C1 NDUFB9 0.365186933 0.78 0.596 3.66E-73 C1 CPNE3 0.303685193 0.484 0.239 3.86E-73 C1 CCDC47 0.332710183 0.524 0.274 3.98E-73 C1 MYADM 0.252210126 0.391 0.16 4.30E-73 C1 LGR4 0.256333742 0.384 0.154 5.33E-73 C1 CCL20 0.89643998 0.348 0.138 6.34E-73 C1 ANG 0.250448834 0.4 0.168 6.99E-73 C1 GATA6 0.26898908 0.41 0.177 1.43E-72 C1 PSMC4 0.331260902 0.551 0.311 1.51E-72 C1 HMG20B 0.281257133 0.466 0.219 1.74E-72 C1 TOB1 0.345056648 0.606 0.349 4.46E-72 C1 PPP1R15A 0.61381414 0.798 0.614 5.98E-72 C1 WDR43 0.325272552 0.506 0.256 8.41E-72 C1 ITPKC 0.369967195 0.348 0.132 9.59E-72 C1 ACTN1 0.264601156 0.458 0.215 1.90E-71 C1 TRIB1 0.486366096 0.522 0.288 2.60E-71 C1 SRSF3 0.402535625 0.692 0.477 3.65E-71 C1 AK2 0.324895693 0.52 0.286 4.25E-71 C1 MGLL 0.305449087 0.56 0.301 5.35E-71 C1 C20orf24 0.343142353 0.562 0.326 5.35E-71 C1

CAPG 0.357879366 0.602 0.364 1.83E-70 C1 CD59 0.329369147 0.605 0.365 2.62E-70 C1 MARCKS 0.362316277 0.663 0.396 5.39E-70 C1 MLEC 0.382204262 0.706 0.456 1.30E-69 C1 KIAA0319L 0.308443838 0.378 0.153 1.54E-69 C1 ERLEC1 0.300970215 0.452 0.222 2.82E-69 C1 ATF3 0.432157135 0.655 0.418 3.20E-69 C1 MRPS18A 0.285762915 0.506 0.262 4.37E-69 C1 STXBP2 0.304914785 0.569 0.31 6.22E-69 C1 TPD52 0.368150978 0.698 0.486 9.55E-69 C1 U2AF1 0.376374673 0.603 0.398 1.01E-68 C1 AGR3 0.566445825 0.708 0.575 1.34E-68 C1 PLSCR1 0.309712915 0.522 0.275 2.22E-68 C1 MRPS10 0.265646093 0.43 0.205 2.25E-68 C1 TMEM87A 0.266198571 0.482 0.24 2.56E-68 C1 SNF8 0.302380666 0.522 0.288 3.09E-68 C1 BRD4 0.357839929 0.53 0.274 3.65E-68 C1 CPNE1 0.278812363 0.484 0.251 4.30E-68 C1 FRG1 0.251712064 0.459 0.217 4.41E-68 C1 LSMD1 0.313645002 0.631 0.39 6.52E-68 C1 WDR1 0.296474803 0.551 0.303 9.26E-68 C1 BBC3 0.300526186 0.401 0.173 1.54E-67 C1 SEC62 0.384109485 0.671 0.461 1.72E-67 C1 WTAP 0.255942215 0.433 0.203 1.73E-67 C1 YWHAZ 0.362783068 0.779 0.612 2.61E-67 C1 PARD6B 0.262011276 0.411 0.184 3.49E-67 C1 ZNRD1 0.281449808 0.471 0.242 6.01E-67 C1 UNC45A 0.259371283 0.337 0.13 1.34E-66 C1 IGF2BP2 0.257781607 0.431 0.195 1.36E-66 C1 MTCH1 0.298070859 0.528 0.292 1.66E-66 C1 BPTF 0.315142056 0.491 0.246 2.02E-66 C1 LMAN1 0.284884456 0.475 0.247 2.29E-66 C1 RAD23B 0.261238435 0.459 0.224 4.55E-66 C1 COX5A 0.417150553 0.728 0.616 6.60E-66 C1 TXNDC17 0.352471798 0.739 0.57 6.79E-66 C1 KTN1 0.344066702 0.708 0.466 8.18E-66 C1 S100A11 0.311717958 0.912 0.839 2.38E-65 C1 44076 0.255098518 0.516 0.278 3.44E-65 C1 CCT4 0.312421383 0.533 0.293 3.48E-65 C1 COPA 0.277837587 0.477 0.237 6.23E-65 C1 UBXN4 0.339546617 0.655 0.433 9.74E-65 C1 EIF4G2 0.332686257 0.655 0.442 1.06E-64 C1 CEBPZ 0.322121965 0.485 0.246 1.13E-64 C1 LAD1 0.329231797 0.562 0.332 1.27E-64 C1 SEC11A 0.341222009 0.563 0.342 1.29E-64 C1 CD97 0.265428259 0.405 0.18 1.53E-64 C1 PYCR1 0.302381583 0.445 0.217 2.06E-64 C1 MRPL13 0.325379769 0.516 0.289 3.97E-64 C1

PRDX4 0.326485404 0.496 0.272 5.31E-64 C1 CHP1 0.323632637 0.522 0.291 5.83E-64 C1 ARL6IP4 0.35948436 0.812 0.648 7.06E-64 C1 IMP3 0.328370622 0.532 0.302 1.08E-63 C1 SUMO2 0.444052612 0.631 0.47 1.27E-63 C1 VARS 0.353930227 0.426 0.2 1.42E-63 C1 TARSL2 0.30445702 0.314 0.117 1.57E-63 C1 U2SURP 0.325377967 0.603 0.359 1.61E-63 C1 IQGAP1 0.294378009 0.601 0.349 5.51E-63 C1 KLF4 0.393835081 0.623 0.397 7.07E-63 C1 WHSC1L1 0.281765167 0.535 0.279 7.76E-63 C1 SUMO3 0.259632313 0.491 0.263 1.77E-62 C1 C11orf31 0.331737089 0.775 0.615 2.48E-62 C1 CHMP2B 0.275327936 0.535 0.297 4.23E-62 C1 SLTM 0.311001709 0.581 0.341 4.25E-62 C1 MUC12 0.326442379 0.367 0.155 8.41E-62 C1 YIPF3 0.27545837 0.516 0.29 1.11E-61 C1 NCOR2 0.255631461 0.347 0.142 1.44E-61 C1 NDUFS5 0.348802351 0.781 0.679 1.72E-61 C1 FDPS 0.427585187 0.592 0.378 2.24E-61 C1 VCP 0.292104825 0.562 0.322 8.57E-61 C1 NDUFC1 0.35291248 0.634 0.458 1.10E-60 C1 RBBP6 0.292996436 0.486 0.25 1.18E-60 C1 MTCH2 0.285374785 0.475 0.258 1.35E-60 C1 NDUFA13 0.278589471 0.918 0.823 2.73E-60 C1 GCN1L1 0.264799735 0.27 0.094 2.75E-60 C1 STOML2 0.324207697 0.556 0.352 3.33E-60 C1 PSMD8 0.345872094 0.594 0.395 3.60E-60 C1 ASS1 0.370174274 0.541 0.303 9.90E-60 C1 IRF2BP2 0.330209422 0.566 0.322 1.66E-59 C1 AUP1 0.30142915 0.643 0.407 4.38E-59 C1 HSPA1A 0.427442404 0.599 0.363 9.09E-59 C1 PARP1 0.31579645 0.534 0.298 9.96E-59 C1 TRMT10C 0.251377218 0.434 0.212 1.05E-58 C1 NR4A2 0.268842962 0.375 0.168 1.22E-58 C1 ANKRD11 0.397054907 0.66 0.405 1.27E-58 C1 BZW2 0.264552985 0.474 0.251 1.51E-58 C1 LDHA 0.473488032 0.63 0.467 2.07E-58 C1 GDF15 0.567113481 0.533 0.313 2.17E-58 C1 NOP10 0.390246055 0.613 0.462 2.53E-58 C1 PCBP1 0.325094659 0.687 0.483 3.96E-58 C1 MPLKIP 0.253830835 0.483 0.262 8.11E-58 C1 TCF25 0.364677926 0.793 0.564 8.33E-58 C1 HIST1H4C 0.550684391 0.712 0.478 8.43E-58 C1 PPP2R1A 0.303964584 0.585 0.362 9.47E-58 C1 BAG1 0.279408652 0.551 0.319 9.82E-58 C1 ILF3 0.351038098 0.612 0.368 1.38E-57 C1 KDELR1 0.314477311 0.584 0.384 5.08E-57 C1

ASPH 0.251234537 0.571 0.324 6.94E-57 C1 NANS 0.361000531 0.576 0.384 8.03E-57 C1 ERO1L 0.304515025 0.435 0.216 1.35E-56 C1 RBM25 0.31393376 0.674 0.437 3.02E-56 C1 CHMP2A 0.305552848 0.687 0.534 3.35E-56 C1 VPS35 0.266813827 0.523 0.301 4.34E-56 C1 CLU 0.289620606 0.506 0.272 9.58E-56 C1 EFNA1 0.377150297 0.559 0.341 9.77E-56 C1 LAPTM4A 0.381241444 0.554 0.363 1.18E-55 C1 RPN2 0.301297663 0.582 0.358 1.25E-55 C1 PGK1 0.387103945 0.582 0.382 1.72E-55 C1 ASL 0.31522707 0.705 0.485 2.91E-55 C1 BLVRB 0.310903035 0.717 0.548 5.82E-55 C1 OCIAD1 0.26480709 0.52 0.3 1.24E-54 C1 HERPUD1 0.376906018 0.583 0.376 1.48E-54 C1 BCLAF1 0.273251875 0.539 0.304 1.74E-54 C1 SOD1 0.339651669 0.795 0.713 1.99E-54 C1 ZC3H12A 0.311503906 0.431 0.222 3.16E-54 C1 NOP56 0.37541982 0.613 0.38 4.23E-54 C1 ANAPC11 0.347047009 0.626 0.442 4.70E-54 C1 PSMC5 0.265336155 0.512 0.302 6.98E-54 C1 OSTC 0.308063497 0.519 0.315 7.85E-54 C1 ENSA 0.290883313 0.599 0.394 1.19E-53 C1 NR2F6 0.251199674 0.444 0.22 2.50E-53 C1 GSTP1 0.261595371 0.926 0.841 6.09E-53 C1 JTB 0.342137426 0.652 0.488 6.13E-53 C1 SUMO1 0.258442868 0.551 0.328 9.54E-53 C1 HOOK2 0.353061225 0.67 0.426 2.68E-52 C1 SBDS 0.306733492 0.615 0.425 3.08E-52 C1 CD164 0.328793798 0.624 0.44 4.55E-52 C1 GPS1 0.250944944 0.42 0.209 4.71E-52 C1 CHCHD2 0.333313691 0.822 0.767 4.72E-52 C1 CDH1 0.286494784 0.608 0.376 8.10E-52 C1 PRDX6 0.307865292 0.553 0.371 9.02E-52 C1 NMT1 0.340511153 0.635 0.392 1.12E-51 C1 YIF1A 0.289175964 0.526 0.324 1.13E-51 C1 DNAJB1 0.324045211 0.56 0.345 1.19E-51 C1 DDX5 0.347532158 0.734 0.631 1.34E-51 C1 ABHD2 0.267108577 0.54 0.306 1.39E-51 C1 TSTA3 0.312190346 0.722 0.545 1.76E-51 C1 RNF145 0.268024914 0.575 0.329 1.79E-51 C1 ERICH1 0.279759725 0.49 0.257 2.10E-51 C1 ATP5F1 0.314683799 0.589 0.39 3.16E-51 C1 VMP1 0.307745298 0.712 0.515 6.15E-51 C1 SERP1 0.346275428 0.647 0.495 6.72E-51 C1 PSMB1 0.336755104 0.609 0.437 7.27E-51 C1 EIF3G 0.318414628 0.674 0.493 8.27E-51 C1 PSMC3 0.290271748 0.61 0.379 1.27E-50 C1

TMED10 0.264107977 0.576 0.358 2.34E-50 C1 CLNS1A 0.269871678 0.473 0.268 4.94E-50 C1 CCT6A 0.293603103 0.575 0.366 2.00E-49 C1 RAC1 0.359537129 0.754 0.674 2.42E-49 C1 NAA10 0.252112607 0.52 0.315 4.12E-49 C1 ZC3H13 0.266976764 0.444 0.235 6.75E-49 C1 SRRM2 0.311078573 0.745 0.551 7.22E-49 C1 FASN 0.291900595 0.361 0.174 2.02E-48 C1 GOLM1 0.327879126 0.681 0.487 2.13E-48 C1 TMEM14B 0.275274838 0.53 0.333 2.89E-48 C1 MRPL55 0.267728669 0.547 0.336 3.12E-48 C1 C8orf33 0.250732522 0.526 0.306 3.17E-48 C1 NQO1 0.339895013 0.668 0.513 6.58E-48 C1 CACYBP 0.250477364 0.485 0.277 7.59E-48 C1 AHI1 0.300693643 0.574 0.327 8.15E-48 C1 CNBP 0.28745932 0.573 0.368 9.89E-48 C1 AK1 0.253635238 0.559 0.358 1.07E-47 C1 CXCL3 0.557664426 0.58 0.384 1.09E-47 C1 ERH 0.313810438 0.574 0.387 1.11E-47 C1 TUBB2A 0.278534842 0.533 0.318 1.40E-47 C1 S100A16 0.317103381 0.642 0.472 5.19E-47 C1 MT1X 0.583654497 0.734 0.577 7.91E-47 C1 CHURC1 0.264273151 0.551 0.351 2.14E-46 C1 PPP4C 0.273925284 0.622 0.424 2.16E-46 C1 EIF4G1 0.294909173 0.59 0.362 3.71E-46 C1 PRPF38B 0.288429953 0.566 0.345 6.67E-46 C1 PEBP1 0.28604744 0.745 0.613 8.88E-46 C1 SLIRP 0.341316081 0.696 0.566 1.71E-45 C1 SPCS2 0.271161922 0.593 0.389 3.72E-45 C1 ATRX 0.259412476 0.569 0.337 4.96E-45 C1 SNRPE 0.316500156 0.612 0.428 9.12E-45 C1 DNMT1 0.269114943 0.334 0.16 1.05E-44 C1 LAMB3 0.339828692 0.541 0.335 1.35E-44 C1 KNOP1 0.324008312 0.551 0.333 1.96E-44 C1 KIAA0101 0.491741121 0.33 0.163 4.77E-44 C1 CDC37 0.268805797 0.676 0.481 8.08E-44 C1 C19orf10 0.280745039 0.556 0.373 1.88E-43 C1 PDXDC1 0.265239116 0.606 0.384 2.02E-43 C1 FHL2 0.344909953 0.451 0.263 8.12E-43 C1 QARS 0.260514756 0.589 0.373 1.06E-42 C1 TAX1BP1 0.273494456 0.635 0.445 1.11E-42 C1 PILRB 0.25471945 0.382 0.192 2.17E-42 C1 POLR2I 0.256971172 0.591 0.404 2.34E-42 C1 EIF4A2 0.282390325 0.694 0.564 3.85E-42 C1 PSMB7 0.252387471 0.594 0.39 3.89E-42 C1 NME1 0.301616009 0.527 0.345 5.09E-42 C1 TMPRSS2 0.264787354 0.449 0.251 5.41E-42 C1 WDR60 0.332638285 0.474 0.267 6.56E-42 C1

EIF3F 0.301170657 0.567 0.39 8.32E-42 C1 VIMP 0.267732125 0.662 0.473 1.03E-41 C1 NDUFS2 0.255001441 0.583 0.392 1.20E-41 C1 HN1 0.322087902 0.697 0.588 2.51E-41 C1 JUND 0.310917908 0.755 0.531 3.06E-41 C1 ANKRD36 0.255864719 0.366 0.183 3.27E-41 C1 IDH2 0.27344544 0.559 0.374 2.28E-40 C1 SPRY1 0.301712879 0.328 0.165 3.57E-40 C1 C1orf35 0.317899221 0.496 0.295 3.82E-40 C1 PPP1CA 0.263115937 0.62 0.439 4.25E-40 C1 TIMM13 0.281950079 0.698 0.534 1.54E-39 C1 AKR1B10 0.275648584 0.52 0.327 1.54E-39 C1 ANXA4 0.279833009 0.658 0.497 6.14E-38 C1 SPINT2 0.29692554 0.704 0.631 1.14E-37 C1 NPC2 0.306178136 0.612 0.464 2.17E-37 C1 NDUFS8 0.250703406 0.689 0.51 3.38E-37 C1 HSPA1B 0.292538717 0.524 0.321 5.29E-37 C1 FBL 0.270680085 0.633 0.431 1.29E-36 C1 GAPDH 0.268512677 0.937 0.906 2.82E-36 C1 CXCL2 0.38921648 0.427 0.252 1.96E-35 C1 DYNLL1 0.290536336 0.734 0.663 2.39E-35 C1 LAMTOR5 0.260252516 0.577 0.429 2.94E-35 C1 TAPBP 0.259775861 0.644 0.432 1.84E-34 C1 HNRNPM 0.253892686 0.638 0.444 5.56E-34 C1 HERC2 0.293499428 0.405 0.231 1.19E-33 C1 ZFP36L1 0.31069548 0.714 0.551 2.75E-32 C1 NDUFB4 0.253107315 0.652 0.548 1.63E-30 C1 PHB 0.250041564 0.605 0.44 1.73E-28 C1 ARPC1B 0.270519526 0.636 0.52 2.72E-28 C1 TSPAN8 0.359692092 0.803 0.779 1.86E-23 C1 NBEAL2 0.291608796 0.257 0.139 6.78E-23 C1 LMO7 0.328187402 0.58 0.444 3.63E-22 C1 TSPAN1 0.266725041 0.613 0.477 8.89E-22 C1 HMGB2 0.255985764 0.378 0.254 2.19E-15 C1 APOA1 4.119028234 0.753 0.097 0.00E+00 C2 APOA4 3.476310681 0.481 0.036 0.00E+00 C2 APOC3 3.141154181 0.464 0.034 0.00E+00 C2 PRAP1 2.984302811 0.964 0.51 0.00E+00 C2 PHGR1 2.852404194 1 0.712 0.00E+00 C2 FABP1 2.783612025 0.949 0.349 0.00E+00 C2 ALDOB 2.726006972 0.884 0.218 0.00E+00 C2 ANPEP 2.377622589 0.937 0.28 0.00E+00 C2 FABP2 2.271238825 0.687 0.125 0.00E+00 C2 CA1 2.149690616 0.562 0.024 0.00E+00 C2 CDHR5 2.057581726 0.924 0.191 0.00E+00 C2 C19orf77 1.925292729 0.933 0.521 0.00E+00 C2 RP11-59E19.1 1.582515533 0.497 0.027 0.00E+00 C2 C11orf86 1.470350835 0.561 0.042 0.00E+00 C2

CDKN2B-AS1 1.389170381 0.455 0.008 0.00E+00 C2 KRT20 1.387379272 0.671 0.106 0.00E+00 C2 CYP3A4 1.354563394 0.413 0.014 0.00E+00 C2 TMPRSS15 1.288040195 0.416 0.013 0.00E+00 C2 APOB 1.199795094 0.34 0.007 0.00E+00 C2 SLC6A19 0.992170074 0.366 0.015 2.17E-288 C2 ZG16 1.075771788 0.371 0.017 5.03E-284 C2 SULT1A2 1.185276746 0.49 0.067 1.55E-249 C2 CDHR2 1.281146265 0.591 0.116 2.81E-244 C2 IFI27 1.367618043 0.979 0.811 2.11E-239 C2 HRASLS2 1.598752776 0.599 0.138 3.16E-235 C2 HPGD 1.229985501 0.579 0.118 8.47E-232 C2 ACE2 0.969627358 0.343 0.024 8.75E-227 C2 ADIRF 2.092901514 0.876 0.569 5.83E-225 C2 CREB3L3 0.787344275 0.307 0.017 7.01E-219 C2 TTC36 0.816809554 0.318 0.019 7.62E-219 C2 LINC00035 1.172232824 0.539 0.108 5.70E-217 C2 MYO15B 1.233159766 0.64 0.171 1.25E-213 C2 GUCA2B 1.26813611 0.329 0.025 2.23E-209 C2 S100A6 0.876343941 1 0.991 7.53E-207 C2 MDK 1.323395753 0.886 0.534 2.43E-200 C2 MYL6 0.891730907 0.983 0.865 9.63E-195 C2 C19orf33 0.978821529 0.977 0.873 4.37E-188 C2 SI 1.21302966 0.466 0.087 8.11E-186 C2 RARRES3 1.356309884 0.64 0.219 1.69E-184 C2 MTTP 0.71181252 0.266 0.017 2.99E-176 C2 CST3 0.965190719 0.952 0.827 1.45E-175 C2 CYP2D6 0.705923696 0.256 0.016 4.69E-172 C2 RBP2 2.026546719 0.401 0.069 1.11E-166 C2 PDZD3 0.834517392 0.364 0.051 5.44E-166 C2 SLC15A1 1.012180079 0.287 0.027 4.27E-163 C2 IL32 1.264576729 0.864 0.6 1.81E-159 C2 ISG15 1.579368348 0.76 0.435 7.95E-154 C2 ESPN 0.99129035 0.461 0.109 4.37E-153 C2 MEP1A 0.876640227 0.371 0.062 1.31E-152 C2 IGJ 1.051697484 0.815 0.451 1.73E-152 C2 SEPP1 1.434476794 0.72 0.381 1.15E-151 C2 RP11-462G2.1 0.907476422 0.278 0.028 2.04E-147 C2 TM4SF5 1.28889594 0.741 0.438 9.74E-147 C2 BLOC1S1 1.015203291 0.829 0.626 2.44E-139 C2 SULT1A1 0.925314999 0.453 0.115 3.71E-139 C2 FAM132A 0.892705724 0.384 0.077 1.98E-138 C2 CRIP1 1.292906754 0.782 0.452 1.78E-137 C2 TM6SF2 0.663720689 0.291 0.041 1.99E-127 C2 CIDEB 0.706936387 0.314 0.052 8.07E-126 C2 TM4SF20 1.154851496 0.632 0.279 7.93E-125 C2 POLD4 1.070840637 0.764 0.548 9.69E-125 C2 AOC1 1.134991045 0.7 0.413 5.73E-121 C2

SMIM22 0.717877327 0.906 0.818 2.84E-119 C2 C2orf88 0.773893233 0.324 0.062 2.84E-117 C2 HLA-A 0.760192325 0.985 0.922 6.83E-113 C2 EDF1 0.638601134 0.944 0.863 1.47E-111 C2 MT2A 1.181408889 0.872 0.691 5.17E-111 C2 VAMP8 0.999176384 0.744 0.541 1.13E-109 C2 CYB5A 1.226072823 0.683 0.471 1.36E-107 C2 PIGR 0.971249481 0.927 0.69 6.28E-107 C2 LINC01133 1.014287967 0.631 0.33 9.97E-103 C2 FTH1 0.687074783 0.993 0.93 2.25E-102 C2 CES2 0.894051879 0.784 0.571 3.27E-102 C2 MS4A8 0.702280454 0.289 0.055 3.90E-101 C2 LEAP2 0.777327933 0.266 0.047 8.57E-100 C2 CTSD 0.869769147 0.778 0.592 4.00E-99 C2 RHOC 0.935828559 0.713 0.499 3.59E-96 C2 FXYD3 0.672920269 0.933 0.74 3.23E-95 C2 TM4SF4 0.86220058 0.479 0.173 5.83E-93 C2 ANKRD9 0.750726231 0.339 0.086 8.82E-93 C2 ATOX1 0.996892339 0.679 0.48 1.34E-92 C2 PRSS3 0.775454085 0.773 0.593 2.17E-88 C2 HLA-C 0.702574467 0.921 0.773 2.93E-85 C2 SLC4A7 0.806710795 0.335 0.089 7.45E-85 C2 HLA-B 0.721857222 0.968 0.889 4.19E-84 C2 ACADVL 0.788941073 0.755 0.587 1.71E-82 C2 GPA33 0.778266647 0.415 0.145 1.35E-81 C2 C15orf48 0.773468568 0.751 0.538 1.18E-80 C2 SERPINA1 1.278047178 0.426 0.17 7.81E-75 C2 NDUFA1 0.597376415 0.871 0.812 4.94E-74 C2 ID1 0.783042507 0.698 0.431 5.88E-72 C2 S100A14 0.682835932 0.778 0.598 3.28E-70 C2 MYO1A 0.725758171 0.376 0.138 3.94E-67 C2 GLRX 0.967178007 0.384 0.156 4.91E-67 C2 RNASE1 1.103982574 0.427 0.182 5.09E-67 C2 AGPAT2 0.779876556 0.707 0.557 3.04E-66 C2 SDCBP2 0.769761397 0.525 0.285 3.79E-65 C2 PRR13 0.747521518 0.686 0.569 9.65E-64 C2 PCK2 0.893268211 0.408 0.184 4.60E-63 C2 SLC5A1 0.758089818 0.3 0.095 5.82E-63 C2 IGLL5 0.392778293 0.621 0.385 8.25E-63 C2 ISG20 0.837286246 0.512 0.285 7.51E-61 C2 H2AFJ 0.737949484 0.664 0.521 2.38E-59 C2 PLAC8 0.784187682 0.61 0.374 2.17E-58 C2 RGS2 0.648909999 0.337 0.119 4.00E-58 C2 CYP3A5 0.75837767 0.653 0.488 1.81E-57 C2 MALL 0.808644457 0.515 0.306 8.47E-56 C2 AMN 0.773058465 0.636 0.477 1.13E-55 C2 CLDN7 0.491542284 0.846 0.756 2.11E-55 C2 CHP2 0.649765177 0.298 0.103 2.79E-55 C2

CYSTM1 0.505145073 0.884 0.766 9.86E-55 C2 KHK 0.646297553 0.251 0.073 1.01E-54 C2 TSPAN1 0.622419483 0.7 0.497 9.47E-54 C2 GSN 0.953122604 0.558 0.371 5.26E-51 C2 PCK1 0.976476868 0.461 0.242 3.98E-50 C2 ACSL5 0.868222334 0.437 0.242 5.82E-50 C2 TMEM37 0.689311981 0.298 0.111 6.21E-50 C2 SPINK1 0.499173224 0.782 0.594 3.49E-49 C2 ATP5D 0.49742402 0.875 0.796 6.55E-49 C2 ATP1A1 0.715454895 0.671 0.58 8.06E-48 C2 MUC13 0.768313141 0.579 0.422 1.71E-47 C2 ACAA1 0.782719519 0.497 0.319 3.49E-47 C2 CCL15 0.723792122 0.365 0.174 5.44E-46 C2 COX5B 0.423290466 0.923 0.87 5.86E-46 C2 KRT8 0.352487136 0.97 0.929 7.95E-46 C2 THOP1 0.663734245 0.344 0.155 1.14E-45 C2 TMSB4X 0.297126255 0.993 0.968 3.08E-45 C2 PSME2 0.608797394 0.76 0.664 5.02E-45 C2 NEAT1 0.536485544 0.908 0.899 4.92E-44 C2 ID3 0.656564473 0.405 0.198 1.15E-43 C2 EPS8L2 0.713662917 0.494 0.312 1.62E-43 C2 DGAT1 0.84177246 0.511 0.353 7.05E-43 C2 MALAT1 0.317192394 0.997 0.995 4.55E-42 C2 AKR7A3 0.821374394 0.551 0.411 6.51E-42 C2 GPX4 0.633968132 0.733 0.693 3.66E-39 C2 MYO7B 0.576521333 0.333 0.153 9.94E-39 C2 CYP4F12 0.490364421 0.258 0.095 2.16E-38 C2 HLA-F 0.645891116 0.599 0.488 5.23E-38 C2 ACHE 0.605895261 0.298 0.127 1.48E-37 C2 TMEM54 0.628034232 0.636 0.548 2.08E-37 C2 UQCR11.1 0.416467765 0.86 0.813 3.08E-36 C2 CFDP1 0.713664853 0.59 0.503 4.67E-36 C2 GUK1 0.484036493 0.784 0.719 6.98E-36 C2 MUC17 0.640387119 0.348 0.177 2.27E-35 C2 MISP 0.550583337 0.613 0.518 9.76E-33 C2 MPST 0.676569961 0.559 0.48 1.05E-31 C2 SH3BGRL3 0.493682688 0.726 0.659 1.91E-31 C2 MTRNR2L12 0.473898467 0.259 0.108 4.60E-30 C2 CAMK2N1 0.60558848 0.36 0.206 3.12E-29 C2 ATP5J 0.588757657 0.636 0.597 3.79E-29 C2 CTSE 0.55397192 0.609 0.432 6.29E-29 C2 SLC22A18 0.612603326 0.442 0.308 1.79E-27 C2 MT1H 1.026222459 0.431 0.272 7.90E-27 C2 COX4I1 0.368754797 0.886 0.838 8.78E-27 C2 UBL5 0.401184172 0.78 0.76 9.28E-27 C2 COX7C 0.416415024 0.861 0.8 1.02E-26 C2 DHRS11 0.596588803 0.332 0.195 1.87E-25 C2 VILL 0.597108633 0.406 0.27 9.84E-25 C2

UQCR10 0.44745256 0.669 0.627 2.08E-24 C2 RP11-294O2.2 0.63358118 0.348 0.214 2.55E-24 C2 MT1G 0.85748038 0.726 0.704 4.26E-24 C2 FUOM 0.66924466 0.38 0.249 5.50E-24 C2 MT1M 0.782821167 0.398 0.251 1.29E-23 C2 SPATS2L 0.564939713 0.605 0.552 3.03E-23 C2 ATP5I 0.326659579 0.862 0.87 3.88E-23 C2 CLTB 0.531273248 0.587 0.5 1.07E-22 C2 GFER 0.580532272 0.332 0.204 2.33E-22 C2 CFL1 0.327467544 0.906 0.843 2.84E-22 C2 CHCHD10 0.423874752 0.691 0.65 4.34E-21 C2 HLA-DRB1 0.73598574 0.547 0.47 8.27E-21 C2 HLA-DRA 0.751839274 0.548 0.456 1.70E-19 C2 OAT 0.700665226 0.413 0.317 2.16E-19 C2 PMM1 0.469865549 0.255 0.133 2.61E-19 C2 VSIG2 0.623195708 0.504 0.431 6.38E-19 C2 SAT2 0.673141763 0.431 0.347 8.99E-19 C2 TXNDC17 0.411673158 0.664 0.623 1.28E-18 C2 COX7B 0.322870298 0.799 0.773 1.43E-18 C2 SULT1B1 0.500166333 0.285 0.166 1.72E-18 C2 UQCRQ 0.355730062 0.796 0.751 3.59E-18 C2 CDKN1A 0.580287808 0.384 0.27 3.99E-18 C2 PSMB10 0.577559956 0.419 0.328 4.32E-18 C2 ATPIF1 0.369135789 0.718 0.715 6.86E-18 C2 COX7A2 0.337572609 0.738 0.689 1.41E-17 C2 SLC6A8 0.458005929 0.267 0.147 4.26E-17 C2 TNFRSF14 0.526602029 0.368 0.26 1.63E-16 C2 TMEM59 0.489647794 0.583 0.542 3.67E-16 C2 CCL28 0.508015153 0.289 0.18 6.94E-16 C2 CD151 0.443040878 0.573 0.547 1.34E-15 C2 GSTA1 0.755341114 0.348 0.244 2.82E-15 C2 PLA2G10 0.612602645 0.364 0.271 6.40E-15 C2 GDA 0.469225419 0.281 0.175 1.21E-14 C2 APOL1 0.646070672 0.292 0.183 1.50E-14 C2 HSD17B2 0.500114633 0.405 0.31 2.97E-14 C2 GADD45B 0.462203688 0.384 0.268 3.49E-14 C2 PEBP1 0.431444715 0.683 0.655 4.89E-14 C2 MT1E 0.491747919 0.749 0.701 9.86E-14 C2 BAIAP2L2 0.4149275 0.255 0.149 1.46E-13 C2 CD74 0.602469605 0.61 0.564 2.48E-13 C2 DUSP1 0.376252341 0.598 0.529 3.22E-13 C2 PPP1R14D 0.619549872 0.309 0.22 3.48E-13 C2 FCGRT 0.494444799 0.559 0.545 7.39E-13 C2 LGALS3BP 0.362148525 0.752 0.763 8.06E-13 C2 ZBTB7B 0.481136512 0.277 0.179 9.18E-13 C2 VPS28 0.410028165 0.596 0.582 1.26E-12 C2 GSDMB 0.511614679 0.317 0.223 1.70E-12 C2 CARD16 0.492277793 0.271 0.174 1.93E-12 C2

PPDPF 0.299188517 0.884 0.884 3.03E-12 C2 NDUFB1 0.380648819 0.621 0.633 4.52E-12 C2 ACO2 0.538365461 0.332 0.254 8.95E-12 C2 GNA11 0.494389239 0.373 0.298 1.25E-11 C2 SLC28A2 0.393816345 0.256 0.153 1.30E-11 C2 MTMR11 0.468267204 0.292 0.2 2.04E-11 C2 TST 0.55634143 0.333 0.259 4.06E-11 C2 FAM46A 0.485385311 0.336 0.246 5.85E-11 C2 MVP 0.445730654 0.521 0.502 1.37E-10 C2 CLDN3 0.405628022 0.551 0.494 3.27E-10 C2 ACADS 0.550773697 0.333 0.265 1.28E-09 C2 ITM2B 0.316690025 0.698 0.641 1.38E-09 C2 PNPLA2 0.482904095 0.383 0.316 2.92E-09 C2 PTGR1 0.574724143 0.318 0.246 4.53E-09 C2 NDUFA3 0.338779545 0.649 0.691 6.25E-09 C2 TYMP 0.475608951 0.39 0.319 7.92E-09 C2 C14orf2 0.308788104 0.711 0.726 1.00E-08 C2 FIS1 0.430669349 0.529 0.543 1.31E-08 C2 AKR1C3 0.435621778 0.421 0.363 1.44E-08 C2 REEP6 0.50743328 0.329 0.264 2.61E-08 C2 XAF1 0.37369627 0.263 0.177 2.69E-08 C2 TNFSF10 0.455707082 0.325 0.253 3.15E-08 C2 AKAP9 0.368843304 0.607 0.637 3.63E-08 C2 CD68 0.465582089 0.318 0.252 3.70E-08 C2 CD63 0.258710406 0.693 0.672 5.32E-08 C2 CBR1 0.63240638 0.391 0.36 6.03E-08 C2 CTSZ 0.479590167 0.321 0.258 8.76E-08 C2 CLDN15 0.414987295 0.325 0.243 1.63E-07 C2 GSTK1 0.455309817 0.503 0.491 1.70E-07 C2 EPHX2 0.417457508 0.291 0.217 1.98E-07 C2 ARHGEF16 0.416609865 0.282 0.203 2.09E-07 C2 PPP1R16A 0.416135167 0.439 0.404 2.67E-07 C2 P4HB 0.294469169 0.682 0.692 2.70E-06 C2 TNFRSF1A 0.535004802 0.35 0.312 7.81E-06 C2 SOD1 0.29016984 0.74 0.742 2.02E-05 C2 TP53I3 0.430329398 0.362 0.312 3.19E-05 C2 ALKBH7 0.346294588 0.51 0.535 5.17E-05 C2 COMTD1 0.447773247 0.42 0.404 6.09E-05 C2 RNF213 0.331551949 0.548 0.553 7.69E-05 C2 POR 0.445206615 0.333 0.289 8.07E-05 C2 SLC9A3R1 0.441200641 0.369 0.345 8.61E-05 C2 SLC25A5 0.345410348 0.618 0.589 1.39E-04 C2 COX17 0.374358687 0.514 0.543 1.54E-04 C2 CALM3 0.399660453 0.5 0.522 1.83E-04 C2 LUZP1 0.395636 0.288 0.231 2.25E-04 C2 ECHDC2 0.438553732 0.315 0.27 2.78E-04 C2 AKR7A2 0.482714382 0.326 0.301 6.14E-04 C2 PSME1 0.296494053 0.609 0.621 7.68E-04 C2

CALM1 0.306526061 0.598 0.621 1.16E-03 C2 FAM3C 0.500322362 0.299 0.265 1.19E-03 C2 MXD1 0.40303699 0.326 0.282 1.38E-03 C2 GNG5 0.37012652 0.497 0.531 1.49E-03 C2 SELENBP1 0.380311816 0.377 0.346 2.14E-03 C2 REEP3 0.435115296 0.289 0.253 2.15E-03 C2 TXNIP 0.438280268 0.353 0.313 2.82E-03 C2 HSD17B11 0.491698253 0.369 0.358 3.44E-03 C2 SCP2 0.357045065 0.478 0.502 3.62E-03 C2 TMEM256 0.447035883 0.372 0.37 3.98E-03 C2 MUC5AC 0.822465297 0.558 0.558 4.46E-03 C2 EPN1 0.412969874 0.366 0.348 5.04E-03 C2 CA2 0.338394349 0.421 0.376 6.84E-03 C2 C4orf3 0.443693159 0.415 0.435 9.35E-03 C2 SLC39A5 0.387182928 0.351 0.326 1.00E-02 C2 DDT 0.285412914 0.395 0.342 1.72E-02 C2 CHMP2A 0.30463879 0.556 0.592 1.80E-02 C2 N4BP2L2 0.312109891 0.506 0.533 2.29E-02 C2 NBL1 0.424597274 0.373 0.365 2.80E-02 C2 PEPD 0.52912792 0.296 0.279 3.44E-02 C2 EPS8L3 0.434956213 0.373 0.367 3.73E-02 C2 SMCHD1 0.396657265 0.336 0.309 3.87E-02 C2 AURKAIP1 0.295405842 0.561 0.62 4.10E-02 C2 PRDX5 0.253307816 0.672 0.711 4.61E-02 C2 SNORA76 0.821116626 0.705 0.452 8.01E-132 C3 FCGBP 1.187064627 0.388 0.11 3.52E-128 C3 SNHG8 0.788883467 0.643 0.438 8.93E-117 C3 POLR2L 0.63192373 0.805 0.707 1.96E-116 C3 SNORD3A 1.041319617 0.438 0.19 1.05E-93 C3 SYT8 0.75547821 0.293 0.096 6.87E-84 C3 CDC42EP5 0.486650514 0.471 0.232 3.24E-80 C3 CYBA 0.45628476 0.844 0.766 4.61E-68 C3 CHCHD10 0.490787057 0.74 0.615 5.02E-67 C3 RPL36A 0.392959085 0.93 0.877 1.27E-60 C3 EFHD2 0.45938101 0.535 0.396 3.01E-50 C3 S100A6 0.460143408 0.99 0.993 7.67E-50 C3 C1orf63 0.49177706 0.488 0.323 1.04E-48 C3 METTL12 0.51401503 0.288 0.134 4.14E-45 C3 RPS23 0.340089338 0.941 0.9 8.24E-44 C3 ACADVL 0.384776441 0.689 0.571 2.58E-43 C3 RPL35A 0.278592776 0.957 0.909 6.39E-42 C3 GSTK1 0.349149974 0.579 0.452 3.01E-39 C3 GKN1 0.349456444 0.258 0.113 3.63E-39 C3 KRT18 0.34462851 0.941 0.895 1.19E-38 C3 HSPG2 0.347371911 0.298 0.151 2.15E-37 C3 ARGLU1 0.461341547 0.682 0.615 2.27E-34 C3 SNHG12 0.393932969 0.256 0.131 1.17E-29 C3 MIF 0.354144594 0.732 0.67 2.30E-28 C3

KRT8 0.297163814 0.953 0.926 8.27E-28 C3 KCNQ1OT1 0.329255253 0.255 0.134 8.35E-27 C3 ATP2C2 0.366131107 0.296 0.178 3.69E-26 C3 MT1H 0.387488053 0.382 0.251 1.17E-25 C3 DMBT1 0.473081894 0.386 0.251 2.98E-25 C3 CLDN15 0.282009095 0.343 0.212 8.48E-25 C3 IGJ 0.33086418 0.573 0.465 2.21E-24 C3 ATPIF1 0.285832136 0.735 0.706 3.52E-23 C3 CD44 0.321651713 0.318 0.206 3.92E-22 C3 ABHD11 0.397765797 0.38 0.285 5.36E-21 C3 JUN 0.436572754 0.825 0.833 5.71E-20 C3 GADD45B 0.386140941 0.364 0.246 7.15E-20 C3 MIB2 0.270697188 0.264 0.161 1.56E-19 C3 SLC25A6 0.317351273 0.767 0.72 1.68E-19 C3 EFCAB4A 0.326379509 0.393 0.293 3.17E-19 C3 IER2 0.380155464 0.717 0.708 3.27E-19 C3 WASH4P 0.310084395 0.409 0.303 4.46E-19 C3 FOSB 0.549451472 0.645 0.612 1.35E-18 C3 AKAP9 0.328465834 0.655 0.622 3.56E-18 C3 SLC38A2 0.351747285 0.377 0.281 8.67E-18 C3 TRPM4 0.258974519 0.284 0.181 1.11E-17 C3 EGR1 0.424589167 0.453 0.365 3.82E-17 C3 ABCC3 0.33592781 0.536 0.468 8.90E-17 C3 INF2 0.288949735 0.353 0.255 3.68E-16 C3 RP11-304L19.5 0.282357094 0.292 0.205 7.56E-15 C3 HEXIM1 0.501684371 0.399 0.321 2.73E-14 C3 SOX4 0.45125972 0.587 0.539 4.90E-14 C3 SNHG9 0.307520311 0.385 0.292 1.19E-13 C3 CLDN3 0.387144638 0.543 0.482 6.43E-13 C3 HSPB1 0.288055794 0.652 0.615 8.22E-13 C3 S100A4 0.85719714 0.32 0.259 1.38E-11 C3 BTG1 0.323849433 0.595 0.541 1.54E-11 C3 TUBA1B 0.323695326 0.602 0.546 6.96E-11 C3 PNISR 0.324958611 0.525 0.483 1.55E-10 C3 PGC 1.125011202 0.322 0.222 4.28E-10 C3 PHLDA2 0.302166889 0.555 0.52 2.42E-09 C3 ERN2 0.251375892 0.453 0.384 6.63E-09 C3 YME1L1 0.322824127 0.445 0.394 7.65E-09 C3 PPP1R10 0.363171192 0.382 0.324 1.98E-08 C3 LIMA1 0.285254878 0.498 0.467 2.52E-08 C3 OLFM4 0.667641628 0.349 0.27 3.15E-08 C3 AMD1 0.336883643 0.455 0.421 1.46E-07 C3 EPHA2 0.300338868 0.255 0.196 3.09E-07 C3 SRSF7 0.257644818 0.597 0.589 1.61E-05 C3 CLDN4 0.274471219 0.807 0.828 4.58E-05 C3 N4BP2L2 0.271261239 0.542 0.524 5.62E-05 C3 RASSF7 0.25741084 0.38 0.343 2.44E-04 C3 LIPF 0.335283612 0.259 0.178 4.76E-04 C3

HNRNPAB 0.250388933 0.43 0.408 1.53E-03 C3 DDX46 0.257643376 0.439 0.426 1.82E-03 C3 IGLL5 0.395521109 0.438 0.407 4.63E-02 C3 REG1A 1.743046013 0.801 0.141 0.00E+00 C4 DPEP1 1.314421591 0.614 0.058 0.00E+00 C4 LIPF 1.294576725 0.906 0.115 0.00E+00 C4 CDKN2A 0.812799103 0.543 0.05 0.00E+00 C4 MAEL 0.74090016 0.49 0 0.00E+00 C4 PGC 0.59413135 0.891 0.173 0.00E+00 C4 NOTUM 0.571664707 0.354 0.003 0.00E+00 C4 LINC00392 0.404024191 0.336 0.001 0.00E+00 C4 BMP4 0.658845951 0.467 0.034 2.55E-294 C4 GHRL 0.555290465 0.439 0.027 2.71E-286 C4 NRCAM 0.289492392 0.273 0.004 4.84E-256 C4 NKD2 0.334452527 0.26 0.003 2.71E-248 C4 TPSAB1 0.41540638 0.381 0.025 5.47E-236 C4 LEMD1 0.332633045 0.272 0.006 6.97E-233 C4 VSNL1 0.396151634 0.311 0.015 3.27E-218 C4 PLA2G2A 1.050889502 0.3 0.016 5.78E-203 C4 IGFBP4 0.703990216 0.474 0.071 1.68E-194 C4 CFD 0.789112448 0.518 0.093 1.86E-184 C4 CLDN2 0.386933428 0.265 0.013 1.03E-183 C4 RP11-357H14.17 1.129177505 0.722 0.237 1.51E-168 C4 RPL36A 0.974855276 0.969 0.885 5.04E-164 C4 OLFM4 1.257135633 0.733 0.24 1.52E-160 C4 REG3A 1.09597425 0.263 0.018 2.23E-158 C4 LGALS3 2.053502328 0.959 0.799 3.15E-156 C4 NEBL 0.308436801 0.267 0.02 9.75E-156 C4 EFNA3 0.301142636 0.315 0.038 2.82E-141 C4 C9orf16 0.93471341 0.887 0.564 1.67E-140 C4 RPL23A 0.900588999 0.985 0.943 1.03E-134 C4 CEACAM5 0.706308284 0.588 0.162 1.20E-130 C4 RNF43 0.61944075 0.536 0.135 2.23E-130 C4 RPL35A 0.775258407 0.992 0.916 1.18E-128 C4 CTD-2314B22.3 0.271503839 0.275 0.03 4.18E-127 C4 FAM84A 0.56397349 0.478 0.106 2.51E-126 C4 TXN 0.85606312 0.957 0.8 6.68E-119 C4 STXBP6 0.325162248 0.358 0.062 4.03E-118 C4 HLA-DRB5 0.60629357 0.371 0.065 4.94E-118 C4 TPPP3 0.58505755 0.417 0.091 1.46E-115 C4 FAM177A1 0.868059555 0.778 0.471 1.44E-112 C4 MLXIPL 0.417681947 0.364 0.066 2.74E-111 C4 ASCL2 0.32984258 0.326 0.052 1.37E-110 C4 ANKH 0.294368453 0.313 0.05 4.21E-109 C4 MBIP 0.500689833 0.406 0.099 8.07E-108 C4 PSMA6 0.588898654 0.512 0.173 4.21E-104 C4 CRIP1 0.698507503 0.826 0.455 2.45E-102 C4 PAQR8 0.557892279 0.462 0.131 4.49E-101 C4

EEF1D 0.671859885 0.975 0.881 8.04E-101 C4 THRA 0.493356711 0.454 0.124 2.44E-100 C4 SOCS4 0.538119762 0.402 0.099 2.12E-98 C4 WDR72 0.370482008 0.369 0.085 1.15E-96 C4 MLLT6 0.560405041 0.5 0.159 3.47E-94 C4 TOMM7 0.715276864 0.874 0.731 3.76E-93 C4 SLC12A2 0.576302084 0.543 0.187 4.15E-93 C4 RPS2 0.623275796 0.998 0.948 1.56E-90 C4 RPS23 0.592118027 0.975 0.905 1.34E-86 C4 TNNC2 0.361742125 0.285 0.052 1.89E-85 C4 FKBP9 0.486176308 0.434 0.137 2.84E-84 C4 KRT18 0.667649222 0.978 0.901 1.40E-81 C4 MDK 0.595060596 0.843 0.548 2.25E-81 C4 SHFM1 0.676413796 0.833 0.622 3.64E-81 C4 PNN 0.960532097 0.815 0.518 4.21E-81 C4 IFITM1 0.382188044 0.404 0.116 8.45E-81 C4 GIT1 0.335855142 0.344 0.084 2.37E-80 C4 C4orf48 0.605571571 0.748 0.389 3.75E-79 C4 IGFBP2 0.295912761 0.351 0.082 8.84E-79 C4 DPP7 0.719532151 0.644 0.309 1.06E-78 C4 CYP2W1 0.4566677 0.305 0.066 4.47E-78 C4 SNHG18 0.293694791 0.369 0.1 9.65E-73 C4 GGH 0.662407836 0.477 0.181 1.61E-72 C4 HMGB1 0.676524164 0.873 0.715 3.74E-72 C4 ANP32B 0.744986377 0.748 0.486 6.74E-72 C4 S100A10 0.68058875 0.967 0.869 1.28E-70 C4 PPP1R1B 0.654444909 0.695 0.412 4.68E-67 C4 DNAJC15 0.650956001 0.714 0.461 2.44E-65 C4 BAZ1A 0.590831278 0.69 0.39 1.30E-62 C4 RPL31 0.477643212 0.99 0.963 4.09E-60 C4 DNPH1 0.562494847 0.79 0.568 4.49E-59 C4 C22orf39 0.387118269 0.462 0.188 9.06E-58 C4 MAPK1IP1L 0.754248295 0.526 0.282 1.04E-57 C4 EPHB2 0.253845836 0.31 0.084 3.39E-57 C4 DEK 0.603737982 0.755 0.502 1.13E-56 C4 AREG 0.297013831 0.318 0.091 1.29E-56 C4 PPP2R3C 0.349750743 0.421 0.159 4.46E-56 C4 COX6C 0.55988526 0.921 0.807 1.20E-55 C4 GKN1 0.252269582 0.404 0.129 1.27E-55 C4 CEACAM6 0.286367695 0.464 0.167 2.85E-55 C4 SNHG7 0.510536705 0.565 0.279 3.44E-55 C4 MACROD1 0.351994108 0.434 0.172 2.18E-54 C4 CD320 0.417465263 0.459 0.192 5.15E-53 C4 SLC2A8 0.307873397 0.339 0.113 2.44E-52 C4 TMSB10 0.379679231 0.997 0.976 2.81E-52 C4 ERAP2 0.306806403 0.343 0.108 7.84E-52 C4 CBX3 0.482305708 0.778 0.541 2.25E-51 C4 LACTB2 0.510852352 0.553 0.289 3.86E-51 C4

CMSS1 0.446441434 0.48 0.221 5.01E-51 C4 NDUFS6 0.501516072 0.841 0.677 8.61E-51 C4 C8orf59 0.557488043 0.724 0.481 2.07E-50 C4 DUT 0.476461626 0.485 0.226 9.04E-50 C4 CDH17 0.468124436 0.656 0.363 1.95E-49 C4 SNHG15 0.413817653 0.498 0.228 3.10E-49 C4 COMMD6 0.564553547 0.768 0.57 5.80E-48 C4 PSMB3 0.633961668 0.699 0.503 2.97E-46 C4 RANBP1 0.577814309 0.618 0.379 4.38E-46 C4 C9orf78 0.452093738 0.531 0.287 7.54E-46 C4 PDCD5 0.494053584 0.651 0.42 3.50E-45 C4 CCDC85B 0.492468862 0.594 0.325 5.21E-45 C4 MSRB2 0.393469673 0.457 0.219 6.83E-45 C4 NSMF 0.415369412 0.399 0.158 1.18E-44 C4 MIF 0.467514642 0.833 0.672 4.48E-44 C4 MCM3 0.423673875 0.399 0.17 1.17E-43 C4 NENF 0.418388567 0.589 0.334 1.47E-43 C4 NFKBIA 0.733524303 0.841 0.621 1.54E-43 C4 TMEM141 0.586062459 0.661 0.433 2.31E-43 C4 KLK10 0.326891386 0.293 0.097 8.66E-42 C4 PLOD3 0.338050193 0.416 0.183 1.20E-41 C4 MYO19 0.257098315 0.358 0.136 1.55E-41 C4 EIF3J 0.477616043 0.863 0.63 1.62E-41 C4 NACA 0.509633714 0.856 0.733 2.27E-41 C4 MRPL52 0.470736574 0.786 0.607 2.45E-41 C4 NXT1 0.36434256 0.409 0.19 4.27E-41 C4 SDF2L1 0.409025728 0.631 0.37 4.92E-41 C4 LTBP4 0.335750685 0.442 0.194 5.26E-40 C4 CHD7 0.412866092 0.495 0.242 5.54E-40 C4 CDX2 0.284144698 0.339 0.13 1.05E-39 C4 HECTD1 0.33489665 0.478 0.24 9.52E-39 C4 ADAP1 0.340983174 0.432 0.194 1.35E-38 C4 GRINA 0.383590357 0.46 0.229 1.76E-38 C4 SPTSSA 0.446698628 0.487 0.265 2.78E-38 C4 WDR24 0.258709048 0.316 0.116 3.33E-38 C4 EDN1 0.548601747 0.528 0.273 4.10E-38 C4 CLDN3 0.416429505 0.735 0.472 4.62E-38 C4 PFDN5 0.381861428 0.841 0.699 5.06E-38 C4 RAC1 0.468593339 0.844 0.683 8.17E-38 C4 BID 0.286300107 0.394 0.177 1.02E-37 C4 BRD7 0.363853396 0.483 0.241 1.39E-37 C4 GSTM3 0.355335377 0.488 0.253 2.72E-36 C4 SNRPD2 0.37440954 0.876 0.714 3.24E-36 C4 TMEM106C 0.317049384 0.437 0.212 5.09E-36 C4 GSTP1 0.40873387 0.94 0.861 1.28E-35 C4 TSTD1 0.412988115 0.621 0.405 1.83E-35 C4 POLR1C 0.310436906 0.411 0.192 3.64E-35 C4 TAF1D 0.44731983 0.72 0.495 4.93E-35 C4

PSME1 0.458808889 0.76 0.602 6.16E-35 C4 AP2B1 0.371163654 0.687 0.441 8.95E-35 C4 PSMD11 0.450904691 0.522 0.317 9.88E-35 C4 IFITM3 0.465664555 0.772 0.577 1.23E-34 C4 PPP1R14B 0.355662949 0.48 0.266 1.85E-34 C4 PTMS 0.323393129 0.472 0.228 2.26E-34 C4 MRPL36 0.391078189 0.47 0.264 2.49E-34 C4 YDJC 0.269957314 0.377 0.171 2.79E-34 C4 ANXA13 0.308314268 0.389 0.178 8.85E-34 C4 EAPP 0.391882568 0.497 0.289 9.36E-34 C4 RARRES1 0.349895994 0.366 0.162 9.58E-34 C4 FERMT1 0.386921097 0.523 0.303 1.79E-33 C4 PSME2 0.500181285 0.79 0.662 2.34E-33 C4 CD74 0.547159254 0.767 0.545 4.26E-33 C4 MCUR1 0.327918435 0.381 0.181 6.16E-33 C4 SNX6 0.395517871 0.53 0.319 7.89E-33 C4 FBXO34 0.32298363 0.371 0.171 1.00E-32 C4 C7orf50 0.352525702 0.444 0.237 1.03E-32 C4 HOXA10 0.25338541 0.356 0.158 3.59E-32 C4 TCEB1 0.42283761 0.652 0.437 4.00E-32 C4 ATHL1 0.255559742 0.257 0.089 7.11E-32 C4 NEDD8 0.38119109 0.714 0.536 2.86E-31 C4 AP1S1 0.371710336 0.518 0.318 9.37E-31 C4 FOXP4 0.25741442 0.348 0.152 1.38E-30 C4 RBMX 0.410433357 0.705 0.476 1.57E-30 C4 RND3 0.443769687 0.646 0.394 2.43E-30 C4 PRELID1 0.439208536 0.626 0.436 4.40E-30 C4 LINC01133 0.309379123 0.591 0.343 5.72E-30 C4 UFM1 0.450855718 0.579 0.388 5.78E-30 C4 CXCL1 0.418741324 0.523 0.276 2.65E-29 C4 PSMD3 0.408996823 0.488 0.296 3.71E-29 C4 MYCBP2 0.278677782 0.447 0.226 7.63E-29 C4 RNF145 0.333686528 0.627 0.388 1.05E-28 C4 RHEB 0.3585498 0.508 0.309 1.38E-28 C4 REXO4 0.351202806 0.483 0.262 1.55E-28 C4 CXCL2 0.358933345 0.528 0.285 1.67E-28 C4 HMGN2 0.423157039 0.677 0.456 1.85E-28 C4 EEF1G 0.480309975 0.545 0.373 2.71E-28 C4 CASC3 0.259996725 0.344 0.155 3.52E-28 C4 PLA2G16 0.373817034 0.548 0.337 5.16E-28 C4 SRGN 0.436886305 0.32 0.133 1.00E-27 C4 PHF14 0.375433048 0.68 0.468 1.13E-27 C4 CHRAC1 0.276769857 0.366 0.177 1.22E-27 C4 C7orf73 0.285047438 0.462 0.258 1.66E-27 C4 CENPW 0.305287221 0.27 0.107 2.61E-27 C4 MRPS17.1 0.305008922 0.421 0.226 2.72E-27 C4 FBL 0.3725207 0.666 0.48 3.16E-27 C4 CHCHD7 0.345288592 0.561 0.355 4.11E-27 C4

C14orf166 0.449463005 0.609 0.436 1.24E-26 C4 CNPY3 0.287989676 0.425 0.231 1.27E-26 C4 TONSL 0.287749792 0.275 0.109 2.85E-26 C4 PSMD5-AS1 0.280761905 0.44 0.226 3.00E-26 C4 C9orf142 0.377911283 0.568 0.359 4.02E-26 C4 POLR2F 0.295283932 0.49 0.292 4.15E-26 C4 SPINK1 0.328621573 0.831 0.593 4.71E-26 C4 WWP1 0.261921387 0.346 0.163 3.67E-25 C4 NTMT1 0.273544306 0.43 0.232 6.15E-25 C4 ARMC10 0.260363964 0.339 0.172 6.93E-25 C4 NUDT1 0.284778176 0.404 0.211 7.00E-25 C4 TBCC 0.311986197 0.386 0.199 8.00E-25 C4 LCN2 0.284289475 0.748 0.509 9.15E-25 C4 SET 0.375930838 0.743 0.574 1.74E-24 C4 BRD9 0.267593158 0.45 0.235 2.11E-24 C4 PAFAH1B3 0.253559634 0.449 0.258 4.11E-24 C4 HNRNPA1 0.397317305 0.849 0.732 4.80E-24 C4 ENY2 0.349923341 0.73 0.541 1.00E-23 C4 CXCL3 0.347515107 0.667 0.425 2.04E-23 C4 NSRP1 0.296211164 0.526 0.33 2.22E-23 C4 IER5L 0.263718288 0.263 0.106 2.46E-23 C4 HSP90AB1 0.353001249 0.891 0.737 3.10E-23 C4 NDUFB2 0.34112454 0.74 0.602 3.50E-23 C4 NCBP2-AS2 0.298687389 0.381 0.202 4.01E-23 C4 ATP1B3 0.443672317 0.553 0.395 4.38E-23 C4 EIF2S2 0.319465213 0.788 0.602 4.65E-23 C4 TMEM123 0.364276717 0.477 0.301 5.53E-23 C4 KRTCAP2 0.325469633 0.684 0.509 1.29E-22 C4 MEA1 0.275337326 0.47 0.283 1.54E-22 C4 DAD1 0.425940011 0.675 0.497 1.88E-22 C4 TSC22D1 0.359688488 0.642 0.438 2.01E-22 C4 FAU 0.271622165 0.952 0.899 2.98E-22 C4 TMEM258 0.319052433 0.765 0.603 3.42E-22 C4 MRP63 0.327981729 0.642 0.469 3.59E-22 C4 TOP2A 0.394661737 0.303 0.135 4.53E-22 C4 TRMT10C 0.322718059 0.452 0.269 7.98E-22 C4 SUB1 0.345167234 0.697 0.537 1.02E-21 C4 RSBN1L 0.307176131 0.571 0.353 1.46E-21 C4 NBL1 0.293848701 0.531 0.345 1.55E-21 C4 SIVA1 0.300440046 0.56 0.37 1.57E-21 C4 METAP2 0.359274521 0.636 0.444 1.77E-21 C4 LSM5 0.397628879 0.578 0.416 6.76E-21 C4 ZNF830 0.293111368 0.349 0.181 1.25E-20 C4 SNRPF 0.309241213 0.7 0.501 1.85E-20 C4 PSMG4 0.264589897 0.437 0.256 2.14E-20 C4 SCFD1 0.252303161 0.387 0.217 2.25E-20 C4 PSMA2.1 0.431679334 0.589 0.435 2.91E-20 C4 DDX21 0.316508582 0.738 0.533 7.37E-20 C4

EIF3B 0.291808512 0.536 0.351 8.35E-20 C4 ID1 0.375548 0.666 0.442 1.05E-19 C4 H2AFV 0.367052085 0.603 0.432 1.95E-19 C4 SNRPG 0.327322844 0.758 0.569 1.96E-19 C4 CKB 0.353781055 0.262 0.12 2.41E-19 C4 PPP1R2 0.251735491 0.399 0.235 2.53E-19 C4 ARHGAP5 0.276853458 0.472 0.294 3.56E-19 C4 SELENBP1 0.466350421 0.508 0.33 4.12E-19 C4 MATN2 0.286428736 0.28 0.135 4.76E-19 C4 PTGES2 0.252989395 0.487 0.315 7.62E-19 C4 POMP 0.381842434 0.662 0.522 7.89E-19 C4 SORD 0.314158026 0.434 0.271 1.11E-18 C4 C6orf132 0.339574061 0.543 0.361 1.20E-18 C4 CISD3 0.307525583 0.646 0.505 1.97E-18 C4 RPA3 0.327777618 0.483 0.315 4.83E-18 C4 NDUFA4 0.373630016 0.811 0.699 5.58E-18 C4 H2AFZ 0.367261247 0.599 0.423 7.80E-18 C4 MRPS33 0.28953977 0.498 0.334 9.42E-18 C4 CD47 0.373288031 0.472 0.317 9.69E-18 C4 ZNF706 0.327732127 0.662 0.506 1.19E-17 C4 CKS1B 0.368574324 0.439 0.281 1.23E-17 C4 PFDN2 0.291634336 0.611 0.434 1.76E-17 C4 DNAJC19 0.287686823 0.478 0.318 2.75E-17 C4 SDF2 0.255701951 0.454 0.293 2.96E-17 C4 SSBP1 0.304955459 0.594 0.435 3.38E-17 C4 PLP2 0.343461616 0.55 0.378 4.20E-17 C4 SAP18 0.293001666 0.695 0.556 5.12E-17 C4 ESF1 0.274828537 0.579 0.383 6.03E-17 C4 TATDN1 0.259713046 0.445 0.282 7.75E-17 C4 COX20 0.281300228 0.593 0.415 8.63E-17 C4 POLE3 0.260750057 0.445 0.277 8.85E-17 C4 MDH2 0.361974713 0.576 0.431 9.37E-17 C4 C15orf48 0.348697136 0.705 0.55 1.05E-16 C4 MRPL41 0.265383206 0.733 0.562 1.47E-16 C4 PUF60 0.282866122 0.576 0.407 1.84E-16 C4 SERPINB5 0.267984954 0.442 0.274 2.90E-16 C4 TMEM261 0.276089467 0.465 0.307 3.60E-16 C4 SURF1 0.283973197 0.485 0.331 3.77E-16 C4 EBPL 0.276657349 0.447 0.279 4.42E-16 C4 PTGES3 0.345308586 0.589 0.452 7.62E-16 C4 RNPS1 0.324180519 0.553 0.41 9.31E-16 C4 GGCT 0.317749042 0.533 0.379 1.02E-15 C4 PSMC6 0.280198266 0.492 0.338 1.27E-15 C4 KNOP1 0.270610506 0.565 0.389 4.42E-15 C4 POLR2K 0.276750297 0.56 0.403 5.65E-15 C4 UCHL3 0.291942265 0.44 0.289 9.74E-15 C4 FABP5 0.37585503 0.593 0.405 2.09E-14 C4 PPA1 0.369801949 0.667 0.526 4.24E-14 C4

MRPL50 0.264580708 0.417 0.27 2.46E-13 C4 SSNA1 0.273282043 0.568 0.422 7.42E-13 C4 GTF3A 0.267584842 0.46 0.315 1.17E-12 C4 CD9 0.277939146 0.634 0.501 7.18E-11 C4 TUBA1B 0.331181962 0.687 0.548 1.30E-10 C4 ASS1 0.30406379 0.507 0.371 6.22E-10 C4 TRIM31 0.299188039 0.593 0.445 3.98E-09 C4 PABPC1 0.253117188 0.919 0.802 7.77E-09 C4 PSMB7 0.250150809 0.576 0.446 3.97E-08 C4 HES1 0.561654133 0.808 0.69 1.76E-07 C4 EIF3E 0.26859726 0.618 0.493 3.15E-05 C4 LY6K 1.392416098 0.915 0.001 0.00E+00 C5 HLA-DPA1 1.236223481 0.859 0.118 0.00E+00 C5 AKR1C4 0.686176115 0.535 0.021 0.00E+00 C5 BNIP3 0.311943162 0.42 0.013 0.00E+00 C5 APBB1IP 0.261171784 0.359 0.013 1.28E-263 C5 FIBCD1 0.321542228 0.399 0.021 8.82E-252 C5 AKR1C2 1.067024284 0.481 0.04 1.36E-237 C5 METTL5 1.07654769 0.899 0.287 5.13E-230 C5 HLA-DPB1 0.866956546 0.808 0.17 7.56E-220 C5 CDCA7 1.115261639 0.723 0.143 1.80E-204 C5 GSTM3 0.887560973 0.836 0.231 4.84E-193 C5 PCBD1 1.023187553 0.927 0.373 9.93E-190 C5 AIFM2 0.555736854 0.606 0.104 2.35E-187 C5 HLA-DMA 0.876756551 0.852 0.254 2.75E-185 C5 FAM213A 0.733172499 0.824 0.229 6.75E-183 C5 SSB 1.112571092 0.932 0.376 3.26E-179 C5 DDT 0.907755606 0.927 0.3 1.12E-176 C5 SFXN4 0.502481813 0.669 0.141 1.01E-174 C5 PPIG 0.953136011 0.953 0.408 2.61E-174 C5 HLA-DRB1 1.201901849 0.958 0.439 1.38E-173 C5 LY6E 1.222637727 0.944 0.408 3.47E-172 C5 RAB40B 0.576401878 0.756 0.182 6.62E-171 C5 RPS2 1.029126636 1 0.95 4.61E-170 C5 EIF3H 1.107833705 0.962 0.475 9.21E-170 C5 HLA-DRA 1.122880167 0.965 0.425 5.31E-169 C5 TATDN1 0.736190014 0.819 0.255 6.68E-167 C5 HAT1 0.536417176 0.662 0.142 2.89E-166 C5 SUMO1 0.914965982 0.911 0.362 3.64E-165 C5 EIF3E 1.207464631 0.967 0.468 2.57E-164 C5 CYHR1 0.523676008 0.77 0.18 2.08E-163 C5 GPX2 1.219818251 0.981 0.607 2.57E-163 C5 QPRT 0.636187479 0.763 0.202 5.70E-156 C5 ZNF503 0.296849221 0.418 0.049 1.80E-155 C5 PTP4A3 0.295493663 0.369 0.038 5.26E-154 C5 TMEM230 0.822657248 0.876 0.335 7.78E-151 C5 PRDX1 1.055866003 0.993 0.631 9.15E-148 C5 TKT 0.985916876 0.958 0.468 1.39E-147 C5

PRDX3 0.72576583 0.85 0.302 5.35E-146 C5 WDR12 0.452054432 0.587 0.123 5.73E-146 C5 TXN 1.194653619 0.998 0.802 1.08E-145 C5 NUPR1 0.667355615 0.467 0.07 2.70E-145 C5 TALDO1 0.810988524 0.925 0.405 7.19E-144 C5 BRK1 0.743082135 0.901 0.374 3.65E-142 C5 ZFAS1 0.979480507 0.984 0.568 1.71E-141 C5 HLA-DQB1 0.557028674 0.688 0.17 3.02E-140 C5 PDZK1IP1 1.061491791 0.871 0.328 1.90E-139 C5 ECHS1 0.823563223 0.899 0.409 8.73E-139 C5 ATP5O 0.923758281 0.958 0.553 5.24E-138 C5 CD74 1.017446959 0.974 0.535 3.97E-137 C5 MRPS16 0.63475184 0.791 0.272 1.26E-136 C5 RGS10 0.399945929 0.538 0.109 3.12E-136 C5 GOT1 0.363195637 0.577 0.121 5.63E-136 C5 UBE2V2 0.569418255 0.756 0.231 7.45E-136 C5 METAP1D 0.272048683 0.397 0.053 7.61E-136 C5 EPHX1 0.504345726 0.57 0.126 7.09E-135 C5 FUOM 0.519910247 0.782 0.222 7.85E-135 C5 BLOC1S2 0.535642293 0.671 0.184 1.17E-134 C5 MRPL43 0.508560007 0.749 0.23 1.68E-132 C5 MGMT 0.543009147 0.822 0.272 7.31E-132 C5 GHITM 0.70687699 0.847 0.328 4.67E-131 C5 GSTO2 0.431908997 0.606 0.148 8.98E-131 C5 GORASP2 0.616228748 0.763 0.251 2.39E-129 C5 BST2 0.729427521 0.901 0.349 3.26E-129 C5 CD44 0.477595599 0.744 0.199 2.63E-128 C5 FASTKD1 0.278892021 0.472 0.081 4.83E-128 C5 DEPTOR 0.365487386 0.526 0.108 1.48E-127 C5 FKBP1A 0.736862807 0.887 0.377 1.70E-127 C5 GAPDH 0.86512972 1 0.909 1.84E-127 C5 GSTM4 0.519111812 0.634 0.163 3.33E-127 C5 C1orf43 0.707503303 0.854 0.338 1.28E-126 C5 LTB 0.527738018 0.354 0.043 2.76E-126 C5 PSMF1 0.457565325 0.692 0.2 2.99E-126 C5 ARID5B 0.509613217 0.603 0.142 2.84E-125 C5 ZFAND1 0.538257007 0.702 0.212 5.68E-125 C5 GRINA 0.486371138 0.735 0.214 9.97E-125 C5 LYRM1 0.388035396 0.58 0.136 1.26E-124 C5 HLA-DMB 0.28428854 0.439 0.072 4.22E-124 C5 DMBT1 1.212288823 0.777 0.253 5.40E-124 C5 HSPD1 0.929683749 0.967 0.487 6.58E-123 C5 GTF3A 0.619192859 0.803 0.291 1.14E-121 C5 AKR7A3 0.730986942 0.899 0.39 1.84E-121 C5 EBAG9 0.514337163 0.768 0.257 2.15E-121 C5 MRPS28 0.455273687 0.714 0.218 4.01E-121 C5 TOP1MT 0.347598137 0.547 0.124 4.86E-120 C5 GPR160 0.730866989 0.772 0.279 1.64E-119 C5

TMEM59 0.781268842 0.96 0.512 9.96E-119 C5 EEF1D 0.684290251 1 0.882 1.45E-118 C5 C11orf1 0.336756719 0.568 0.136 1.60E-118 C5 RPIA 0.418697419 0.688 0.201 1.77E-118 C5 ANAPC16 0.595250914 0.824 0.331 8.74E-118 C5 KRTCAP3 0.652364378 0.826 0.332 1.46E-117 C5 KCNQ1OT1 0.453717933 0.603 0.136 3.10E-117 C5 MRPL15 0.562413216 0.732 0.246 2.46E-116 C5 MLTK 0.377689016 0.484 0.098 2.74E-116 C5 DDOST 0.583324816 0.777 0.285 1.85E-115 C5 FTH1 1.051571518 1 0.933 2.77E-115 C5 UQCRB 0.737809427 0.988 0.782 2.48E-114 C5 PTGR1 0.570960291 0.704 0.217 1.94E-113 C5 NPM3 0.420074375 0.603 0.163 1.70E-112 C5 CASP8 0.370138563 0.624 0.163 7.34E-111 C5 TSTA3 0.786629681 0.972 0.575 4.32E-110 C5 FAU 0.579412856 0.998 0.897 4.89E-110 C5 VDAC2 0.731147333 0.885 0.422 4.78E-109 C5 SLC39A4 0.647261026 0.897 0.398 8.54E-109 C5 H1F0 0.46815586 0.643 0.174 9.80E-109 C5 EMG1 0.412108058 0.65 0.194 6.37E-108 C5 COPS5 0.514852998 0.725 0.256 1.83E-107 C5 NDUFB5 0.64286018 0.843 0.357 5.92E-107 C5 UQCRC2 0.57737949 0.854 0.354 6.90E-107 C5 BAIAP2 0.289894925 0.545 0.128 9.94E-107 C5 CISD1 0.513713543 0.796 0.3 1.21E-106 C5 MRTO4 0.38603772 0.585 0.158 7.95E-106 C5 OLA1 0.549558407 0.758 0.273 5.07E-105 C5 FTL 0.941554098 1 0.911 7.18E-105 C5 EMC2 0.388617493 0.596 0.17 7.90E-105 C5 MRPL51 0.597818199 0.883 0.383 4.37E-103 C5 ATP6V0B 0.662539574 0.885 0.414 4.47E-103 C5 COX7A2L 0.62955003 0.845 0.365 4.84E-103 C5 EIF1 0.72548574 0.995 0.862 6.06E-103 C5 TMEM50A 0.527928688 0.822 0.335 1.45E-102 C5 ATP1B3 0.664677172 0.864 0.374 4.13E-102 C5 ORMDL1 0.39538932 0.688 0.221 1.24E-101 C5 TMEM45B 0.568836279 0.763 0.278 2.81E-101 C5 IFI6 0.927297958 0.836 0.342 3.13E-101 C5 ANXA7 0.390789508 0.692 0.228 5.17E-101 C5 SLC39A1 0.407368791 0.643 0.2 6.63E-101 C5 PDLIM1 0.671775328 0.887 0.425 8.46E-101 C5 ENC1 0.331876951 0.549 0.133 9.73E-101 C5 SUMO2 0.71058078 0.939 0.49 4.20E-100 C5 CD27-AS1 0.250724734 0.467 0.102 4.23E-100 C5 NOP58 0.532286372 0.808 0.315 3.85E-99 C5 NME3 0.4450967 0.784 0.289 7.55E-99 C5 GPAA1 0.521559003 0.784 0.303 1.43E-98 C5

DEGS2 0.342615737 0.603 0.164 1.61E-98 C5 TERF1 0.317807399 0.627 0.186 5.31E-97 C5 MRPL37 0.374802462 0.648 0.213 7.39E-97 C5 NDUFB9 0.689679341 0.981 0.632 8.69E-97 C5 ATP5F1 0.671260091 0.901 0.421 9.34E-97 C5 UQCRH 0.67015242 0.984 0.703 2.72E-96 C5 VPS28 0.629669844 0.953 0.552 3.54E-96 C5 PTRH1 0.296063286 0.594 0.167 4.16E-96 C5 PPP1R16A 0.558665928 0.864 0.369 8.70E-96 C5 RPL35A 0.57906004 1 0.918 2.38E-95 C5 CKS1B 0.496492343 0.735 0.261 4.53E-95 C5 ATP5G3 0.79197483 0.979 0.684 8.76E-95 C5 AKR1C3 0.911359912 0.779 0.335 2.16E-94 C5 SDHC 0.528580966 0.791 0.322 3.55E-94 C5 ITGA6 0.535521618 0.847 0.347 3.95E-94 C5 FAM45A 0.29624774 0.563 0.154 4.70E-94 C5 PSMA7 0.704872149 0.967 0.561 7.58E-94 C5 TMEM176A 0.497356607 0.808 0.306 5.33E-93 C5 SLC40A1 0.513672334 0.782 0.285 1.18E-92 C5 CD9 0.703044414 0.927 0.481 1.28E-92 C5 RSL1D1 0.553343778 0.838 0.372 1.29E-92 C5 TMEM106C 0.394205556 0.646 0.202 1.43E-92 C5 COX4I1 0.571527027 1 0.831 2.20E-92 C5 EEF1A1 0.684080018 1 0.937 2.39E-92 C5 PDIA2 0.278169254 0.319 0.049 2.74E-92 C5 RER1 0.496809385 0.833 0.36 3.50E-92 C5 GLRX3 0.41579365 0.655 0.22 5.11E-92 C5 POLR2K 0.572847424 0.847 0.384 6.80E-92 C5 TEX264 0.401483039 0.69 0.243 7.28E-92 C5 PAPOLA 0.491022378 0.838 0.357 8.01E-92 C5 KLK1 0.386531545 0.458 0.101 2.14E-91 C5 SPCS2 0.628957918 0.894 0.422 2.33E-91 C5 DCAF13 0.390783856 0.681 0.225 2.36E-91 C5 CALM1 0.656286633 0.951 0.589 3.94E-91 C5 TMEM126A 0.324100536 0.587 0.18 2.67E-90 C5 EIF3L 0.540034171 0.789 0.323 2.98E-90 C5 MINOS1 0.648261476 0.941 0.527 3.41E-90 C5 EMC3 0.31864515 0.589 0.176 4.30E-90 C5 C21orf59 0.386692585 0.695 0.25 5.28E-90 C5 ATP6V1G1 0.628338128 0.937 0.463 7.62E-90 C5 MRPL24 0.437415743 0.704 0.262 1.22E-89 C5 UFC1 0.549691688 0.894 0.427 1.54E-89 C5 MDH2 0.609875239 0.878 0.41 7.36E-89 C5 HLA-B 0.694561988 1 0.892 1.22E-88 C5 MRPS6 0.383114477 0.606 0.192 1.91E-88 C5 TMEM123 0.417712078 0.749 0.284 5.17E-88 C5 PUF60 0.50704451 0.857 0.388 5.34E-88 C5 NDUFB3 0.650613002 0.939 0.568 6.20E-88 C5

TMEM50B 0.420915847 0.718 0.269 1.08E-87 C5 CUTA 0.563624012 0.913 0.445 2.45E-87 C5 ISCA1 0.344481309 0.603 0.194 4.02E-87 C5 EXOSC1 0.267862212 0.509 0.137 6.48E-87 C5 TXNDC12 0.366078926 0.664 0.23 8.20E-87 C5 NQO1 0.737828917 0.948 0.534 1.13E-86 C5 EIF3D 0.494301272 0.779 0.328 1.65E-86 C5 SMC3 0.325364853 0.606 0.185 3.87E-86 C5 MKKS 0.432400679 0.728 0.281 4.71E-86 C5 HSD17B11 0.466950486 0.793 0.322 5.61E-86 C5 ERH 0.568166373 0.899 0.413 6.81E-86 C5 MOB4 0.325605613 0.624 0.206 8.94E-86 C5 PPA1 0.695386208 0.923 0.509 2.07E-85 C5 SSR2 0.600459545 0.906 0.481 2.45E-85 C5 HSP90AA1 0.677531956 0.991 0.715 2.51E-85 C5 TIMM9 0.316678789 0.613 0.196 3.13E-85 C5 VPS26A 0.260685526 0.523 0.149 1.04E-82 C5 PEX2 0.330214821 0.636 0.212 3.92E-82 C5 RAB2A 0.599679719 0.918 0.466 4.58E-82 C5 SLC52A2 0.404519785 0.751 0.302 6.69E-82 C5 EXOSC4 0.388288723 0.7 0.262 6.77E-82 C5 EIF1B 0.336761627 0.688 0.248 1.06E-81 C5 DDRGK1 0.449003168 0.815 0.362 4.75E-81 C5 NDUFB8.1 0.581189894 0.915 0.5 5.07E-81 C5 CLN3.1 0.292101367 0.585 0.184 6.11E-81 C5 SLC25A26 0.274733682 0.549 0.165 6.28E-81 C5 C20orf27 0.314656943 0.573 0.178 6.46E-81 C5 ATP5L 0.567402745 0.988 0.725 9.63E-81 C5 MGST2 0.528771126 0.873 0.414 1.27E-80 C5 PGD 0.303041719 0.523 0.153 1.36E-80 C5 CAMK2G 0.278896471 0.549 0.156 1.37E-80 C5 RBCK1 0.443269596 0.772 0.323 2.34E-80 C5 LYRM4 0.300360201 0.577 0.183 2.66E-80 C5 EMP2 0.468325129 0.831 0.353 3.85E-80 C5 MRPL9 0.329632647 0.592 0.198 4.10E-80 C5 APMAP 0.300754785 0.624 0.209 1.38E-79 C5 HSPE1 0.644202944 0.988 0.691 2.75E-79 C5 MRPL20 0.464663959 0.826 0.372 2.91E-79 C5 LAPTM4A 0.562970857 0.885 0.39 4.06E-79 C5 GID8 0.307971988 0.61 0.212 4.82E-79 C5 NAA20 0.387913171 0.702 0.272 6.19E-79 C5 NACA 0.59162276 0.986 0.726 8.72E-79 C5 ATP5G1 0.711226829 0.911 0.523 1.31E-78 C5 NDUFA9 0.40054749 0.707 0.27 1.91E-78 C5 RPS23 0.516745834 1 0.906 3.91E-78 C5 REXO2 0.318573047 0.585 0.192 1.29E-77 C5 NIFK 0.377491037 0.69 0.254 1.45E-77 C5 RRS1 0.292410142 0.533 0.161 1.69E-77 C5

TRAM1 0.479677239 0.803 0.335 3.65E-77 C5 TMBIM4.1 0.489012091 0.784 0.339 4.36E-77 C5 ASPH 0.59817761 0.817 0.375 4.98E-77 C5 TM2D1 0.252164554 0.521 0.153 6.66E-77 C5 TOMM22 0.378902146 0.744 0.291 7.72E-77 C5 EI24 0.412359817 0.777 0.324 1.13E-76 C5 ARMC1 0.251687169 0.474 0.131 1.58E-76 C5 COX6C 0.593881282 0.995 0.805 2.36E-76 C5 LAMTOR1 0.445174395 0.836 0.383 4.68E-76 C5 TMEM179B 0.438352805 0.735 0.306 1.98E-75 C5 APRT 0.588940652 0.951 0.608 2.85E-75 C5 ATP5G2 0.578240522 0.962 0.619 3.93E-75 C5 BANF1 0.448180219 0.864 0.377 4.41E-75 C5 ANAPC13 0.308659343 0.615 0.214 4.95E-75 C5 TMEM176B 0.459049616 0.819 0.34 4.98E-75 C5 PSMD4 0.438855487 0.845 0.387 2.04E-74 C5 ZC3H15 0.503563621 0.873 0.439 2.69E-74 C5 IFITM3 0.744672398 0.948 0.568 2.91E-74 C5 SPCS1 0.524677816 0.913 0.483 4.15E-74 C5 MIEN1 0.381837901 0.772 0.331 6.10E-74 C5 NOC2L 0.285472779 0.646 0.223 2.87E-73 C5 IMPDH2 0.491910072 0.805 0.364 2.97E-73 C5 PSMB5 0.44681019 0.817 0.338 7.18E-73 C5 AKR1A1 0.484304985 0.927 0.48 9.19E-73 C5 44089 0.443049523 0.798 0.36 1.18E-72 C5 LCN2 1.018095129 0.908 0.504 1.39E-72 C5 ATRAID 0.421049741 0.784 0.329 1.39E-72 C5 HNMT 0.316081765 0.688 0.26 5.17E-72 C5 SQSTM1 0.683575218 0.937 0.586 5.53E-72 C5 DUSP23 0.333857904 0.7 0.275 1.14E-71 C5 BTF3 0.578922521 0.948 0.611 1.29E-71 C5 MAGOH 0.327736418 0.709 0.276 1.30E-71 C5 PMVK 0.299823873 0.709 0.275 1.59E-71 C5 TMEM97 0.414848864 0.683 0.264 1.98E-71 C5 CNN3 0.264677203 0.378 0.087 2.53E-71 C5 ABHD14B 0.369482188 0.725 0.297 2.73E-71 C5 SDHB 0.374561571 0.688 0.279 3.89E-71 C5 DPP7 0.307634357 0.777 0.309 3.98E-71 C5 SLMO2 0.370681489 0.683 0.276 2.00E-70 C5 HNRNPF 0.495586543 0.84 0.407 2.00E-70 C5 CTSA 0.372940379 0.798 0.357 3.63E-70 C5 TMED10 0.459527187 0.854 0.398 4.10E-70 C5 TAF9 0.331153778 0.697 0.276 5.11E-70 C5 RAMP1 0.368531469 0.533 0.161 5.60E-70 C5 SSR3 0.456564879 0.85 0.389 6.42E-70 C5 DRAM2 0.30732445 0.582 0.206 7.43E-70 C5 ITPA 0.337803575 0.735 0.301 1.23E-69 C5 NSMCE1 0.263703126 0.601 0.209 1.24E-69 C5

DPM2 0.30639761 0.692 0.27 1.31E-69 C5 MANBAL 0.253797677 0.538 0.176 1.59E-69 C5 SMDT1 0.39416737 0.812 0.376 1.84E-69 C5 ERP44 0.43438731 0.728 0.307 3.11E-69 C5 ACTG1 0.737203156 0.998 0.857 4.17E-69 C5 C14orf1 0.347965294 0.641 0.236 6.36E-69 C5 HAX1 0.335312043 0.688 0.277 1.60E-68 C5 TMX2 0.327909916 0.61 0.224 1.77E-68 C5 HTATIP2 0.404289483 0.77 0.336 2.01E-68 C5 CHCHD3 0.276952214 0.533 0.177 3.63E-68 C5 ENO1 0.638086935 0.92 0.572 4.23E-68 C5 UROS 0.267124593 0.54 0.182 1.24E-67 C5 MRPS33 0.355459021 0.749 0.318 1.35E-67 C5 MED30 0.273047972 0.601 0.211 3.68E-67 C5 REEP5 0.323446098 0.711 0.29 3.70E-67 C5 CHCHD1 0.29788581 0.697 0.28 3.92E-67 C5 DPM1 0.312028 0.615 0.227 7.35E-67 C5 HMGN2 0.602898855 0.876 0.447 1.30E-66 C5 EIF3F 0.499367643 0.866 0.416 2.10E-66 C5 MRPL13 0.405038034 0.791 0.331 3.05E-66 C5 PSMA3 0.468334336 0.793 0.362 4.13E-66 C5 CYB5B 0.422591144 0.643 0.256 5.10E-66 C5 CAPZB 0.405173855 0.786 0.373 7.00E-66 C5 TCEB1 0.476227926 0.862 0.427 7.98E-66 C5 EEF1B2 0.551862072 0.984 0.752 9.69E-66 C5 SDHD 0.347506827 0.709 0.292 1.00E-65 C5 NDUFA5 0.319675985 0.742 0.311 4.54E-65 C5 DERL1 0.285139903 0.606 0.225 6.05E-65 C5 MPC2 0.456143701 0.864 0.415 6.94E-65 C5 RNF114 0.383330362 0.664 0.279 9.93E-65 C5 PABPC1 0.524244652 0.998 0.799 1.07E-64 C5 POLR2F 0.303360306 0.7 0.281 1.52E-64 C5 NDUFC2 0.483410691 0.908 0.485 2.04E-64 C5 AIG1 0.260904036 0.488 0.157 3.25E-64 C5 TCEA1 0.356205301 0.791 0.351 4.45E-64 C5 POLR1D 0.423470957 0.836 0.414 4.71E-64 C5 TSTD1 0.404417362 0.838 0.394 1.41E-63 C5 ZNF593 0.365982388 0.789 0.364 1.68E-63 C5 DCTPP1 0.327003928 0.725 0.295 1.93E-63 C5 MRPS25 0.271014659 0.662 0.253 5.10E-63 C5 FAM204A 0.252033713 0.561 0.2 7.82E-63 C5 NPM1 0.568904019 0.937 0.572 9.33E-63 C5 HSPA8 0.605138493 0.934 0.568 1.32E-62 C5 ESD 0.356382509 0.728 0.296 2.35E-62 C5 ADCK3 0.250907394 0.542 0.185 2.65E-62 C5 PPAP2C 0.429465652 0.777 0.373 4.14E-62 C5 APOA1BP 0.313722619 0.725 0.305 5.07E-62 C5 NPC2 0.489159852 0.913 0.481 1.06E-61 C5

ZNF706 0.51083112 0.901 0.491 1.99E-61 C5 ENY2 0.450616798 0.92 0.531 3.83E-61 C5 ZNF511 0.299625903 0.552 0.2 7.87E-61 C5 NUDC 0.379544478 0.786 0.368 2.07E-60 C5 C9orf142 0.339418446 0.775 0.349 2.53E-60 C5 MYC 0.342632759 0.671 0.264 2.78E-60 C5 LSM3 0.38940311 0.796 0.368 6.15E-60 C5 PSAP 0.427910726 0.911 0.509 6.86E-60 C5 SCCPDH 0.281513363 0.594 0.224 8.61E-60 C5 ILF2 0.35766125 0.718 0.302 8.84E-60 C5 ATP6V0E1 0.432493847 0.859 0.44 1.09E-59 C5 CHMP4C 0.301087183 0.669 0.277 1.29E-59 C5 NFIA 0.250143675 0.507 0.168 1.48E-59 C5 PARK7 0.448654503 0.859 0.439 1.95E-59 C5 TXN2 0.311663281 0.77 0.355 2.23E-59 C5 APEX1 0.391013515 0.784 0.356 3.06E-59 C5 CCT7 0.363215403 0.73 0.312 9.76E-59 C5 ARPC4 0.294000542 0.681 0.287 9.88E-59 C5 CNBP 0.444102935 0.843 0.404 1.25E-58 C5 YIF1A 0.376853395 0.803 0.359 1.30E-58 C5 NSFL1C 0.277121604 0.646 0.262 1.33E-58 C5 PFDN2 0.446248095 0.836 0.421 2.05E-58 C5 HIGD2A 0.366410394 0.817 0.397 2.23E-58 C5 TMEM9B 0.283216634 0.57 0.219 2.32E-58 C5 NOB1 0.30805733 0.61 0.241 3.46E-58 C5 ARPC1A 0.390097958 0.796 0.365 6.29E-58 C5 SELM 0.369765969 0.472 0.157 7.05E-58 C5 GDI2 0.351859615 0.728 0.321 8.27E-58 C5 GS1-251I9.4 0.290068401 0.751 0.342 1.84E-57 C5 ATP5C1 0.49692243 0.831 0.419 2.13E-57 C5 GNB2L1 0.448245643 0.995 0.861 2.55E-57 C5 NDUFAB1 0.415176259 0.869 0.419 4.95E-57 C5 TSPAN15 0.252508787 0.615 0.243 5.56E-57 C5 DAP3 0.274592725 0.676 0.284 5.88E-57 C5 ALG5 0.314828091 0.674 0.277 8.58E-57 C5 MGST3 0.592561783 0.908 0.533 8.59E-57 C5 MRPL41 0.448687774 0.932 0.551 2.46E-56 C5 MRPL48 0.254884347 0.577 0.22 2.51E-56 C5 TMEM219 0.335448873 0.831 0.401 2.75E-56 C5 PRR15L 0.343388308 0.697 0.299 5.05E-56 C5 SAR1A 0.31765106 0.624 0.259 8.50E-56 C5 PYURF 0.264669164 0.681 0.281 1.07E-55 C5 WASF2 0.317081132 0.707 0.308 1.63E-55 C5 ACP1 0.365250988 0.843 0.402 1.94E-55 C5 SERBP1 0.454566922 0.923 0.552 2.17E-55 C5 MEAF6 0.250719901 0.678 0.273 3.41E-55 C5 KIF5B 0.508449205 0.803 0.42 1.11E-54 C5 CCT3 0.411282422 0.864 0.434 1.63E-54 C5

JTB 0.458989656 0.911 0.513 2.69E-54 C5 GABARAPL2 0.331719802 0.782 0.352 2.72E-54 C5 YTHDF2 0.26498706 0.622 0.255 9.85E-54 C5 TMED9 0.354611461 0.775 0.374 1.19E-53 C5 FAM162A 0.381935909 0.808 0.403 1.85E-53 C5 SH3YL1 0.357058946 0.775 0.352 6.75E-53 C5 CHCHD7 0.281259905 0.756 0.346 6.76E-53 C5 ATP5H 0.44306098 0.913 0.508 9.77E-53 C5 TPI1 0.500937522 0.967 0.69 1.33E-52 C5 ADRM1 0.361372679 0.784 0.387 1.98E-52 C5 NDUFA8 0.351952549 0.674 0.307 2.37E-52 C5 SYPL1 0.299488902 0.716 0.32 2.66E-52 C5 CYBA 0.413988333 0.984 0.774 3.39E-52 C5 SEC61B 0.475812464 0.927 0.523 4.38E-52 C5 MRPL11 0.29512817 0.678 0.294 6.06E-52 C5 AHCY 0.311338772 0.648 0.282 7.44E-52 C5 APH1A 0.318123123 0.763 0.35 1.17E-51 C5 MGST1 0.400339742 0.822 0.368 2.02E-51 C5 GSTA1 0.409893666 0.589 0.229 2.34E-51 C5 PHB2 0.328950255 0.763 0.357 2.86E-51 C5 COPZ1 0.290356417 0.669 0.295 3.01E-51 C5 PSMD3 0.264105632 0.664 0.288 6.55E-51 C5 SNRPB 0.463440821 0.899 0.494 8.44E-51 C5 MRP63 0.345677752 0.862 0.456 1.53E-50 C5 CMPK1 0.410283794 0.84 0.425 1.90E-50 C5 PHPT1 0.373777752 0.908 0.521 1.92E-50 C5 NDUFA10 0.285676806 0.73 0.34 2.36E-50 C5 PPP1R1B 0.377823861 0.826 0.411 2.38E-50 C5 C6orf48 0.295927266 0.735 0.337 2.90E-50 C5 LEPROT 0.253699103 0.519 0.202 3.22E-50 C5 POMP 0.444472805 0.908 0.506 3.28E-50 C5 CDC42 0.447263551 0.857 0.474 3.44E-50 C5 SAP18 0.387163199 0.92 0.542 3.45E-50 C5 ERGIC3 0.405274094 0.885 0.498 3.75E-50 C5 TOMM20 0.42031847 0.85 0.462 4.20E-50 C5 C9orf16 0.410966465 0.934 0.572 5.67E-50 C5 HMGN3 0.284565756 0.65 0.277 5.95E-50 C5 SF3B14 0.409297957 0.847 0.442 7.08E-50 C5 RPN2 0.399400262 0.808 0.404 9.49E-50 C5 UBE2I 0.293311538 0.756 0.352 1.10E-49 C5 CLNS1A 0.290705937 0.714 0.307 1.36E-49 C5 CPNE3 0.29719504 0.674 0.294 1.60E-49 C5 MRPS26 0.25179851 0.711 0.32 1.90E-49 C5 MRPS34 0.333963545 0.843 0.43 3.52E-49 C5 ARRDC1 0.262912186 0.695 0.314 4.99E-49 C5 COA4 0.316688416 0.779 0.374 6.25E-49 C5 LINC00493 0.305576748 0.859 0.435 7.49E-49 C5 SIVA1 0.322291358 0.761 0.36 9.85E-49 C5

CD47 0.349230172 0.681 0.305 1.38E-48 C5 ANXA4 0.488147165 0.911 0.522 1.38E-48 C5 FKBP4 0.269842494 0.669 0.295 1.45E-48 C5 MLF2 0.306011105 0.718 0.339 9.78E-48 C5 OSTC 0.328086521 0.763 0.353 1.14E-47 C5 HINT1 0.420635068 0.958 0.634 1.88E-47 C5 LACTB2 0.278612118 0.65 0.29 3.01E-47 C5 IMP4 0.255632582 0.671 0.308 3.96E-47 C5 MRPL50 0.258929564 0.61 0.258 4.00E-47 C5 VDAC1 0.42671572 0.899 0.504 1.09E-46 C5 TMEM141 0.321609754 0.824 0.427 3.10E-46 C5 EBNA1BP2 0.279573437 0.662 0.297 3.13E-46 C5 NAP1L1 0.347247552 0.601 0.261 8.02E-46 C5 DDX21 0.361150806 0.894 0.527 1.22E-45 C5 NDUFA6 0.299968779 0.8 0.41 1.31E-45 C5 AP2M1 0.3447242 0.735 0.368 1.66E-45 C5 MRFAP1 0.265324324 0.714 0.324 1.85E-45 C5 EIF6 0.397918271 0.904 0.505 2.01E-45 C5 NUTF2 0.298417845 0.735 0.343 3.65E-45 C5 RAB25 0.354557834 0.822 0.408 5.24E-45 C5 DPY30 0.253179687 0.746 0.345 6.02E-45 C5 COX8A 0.450080672 0.972 0.701 1.17E-44 C5 SLC3A2 0.369458422 0.69 0.32 1.21E-44 C5 LYPLA1 0.276649354 0.697 0.323 1.31E-44 C5 EIF5 0.313864722 0.862 0.455 6.38E-44 C5 UBE2N 0.255213586 0.575 0.247 6.71E-44 C5 PSMB7 0.375672704 0.822 0.43 1.71E-43 C5 SRPRB 0.256021784 0.587 0.254 2.26E-43 C5 TMEM14B 0.276225446 0.791 0.368 2.27E-43 C5 NHP2L1 0.341660548 0.869 0.47 3.42E-43 C5 EIF3A 0.361932743 0.824 0.447 6.92E-43 C5 COA3 0.334988137 0.805 0.413 7.64E-43 C5 CALM2 0.448727972 0.96 0.68 1.04E-42 C5 HIGD1A 0.262413932 0.66 0.316 1.86E-42 C5 HM13 0.261969269 0.716 0.345 2.00E-42 C5 PTGES3 0.343023905 0.84 0.436 3.09E-42 C5 SUCLG1 0.293085948 0.735 0.356 7.72E-42 C5 DECR1 0.283908761 0.744 0.345 1.13E-41 C5 HSPA1A 0.40614706 0.791 0.415 1.36E-41 C5 C8orf59 0.375155345 0.871 0.477 2.34E-41 C5 NME1 0.338816609 0.775 0.377 2.38E-41 C5 C14orf166 0.340850911 0.819 0.424 3.07E-41 C5 TPD52 0.436702174 0.885 0.532 9.44E-41 C5 EIF3K 0.375256026 0.951 0.59 2.92E-40 C5 C10orf10 0.292472935 0.35 0.108 3.51E-40 C5 RSL24D1 0.260785021 0.751 0.357 5.37E-40 C5 C14orf2 0.333945542 0.972 0.703 6.07E-40 C5 PGAM1 0.29221893 0.695 0.343 6.08E-40 C5

PTMA 0.370959981 1 0.958 9.93E-40 C5 AUP1 0.297816528 0.843 0.459 1.17E-39 C5 ANXA11 0.39530443 0.84 0.488 1.43E-39 C5 IDH2 0.341009684 0.805 0.407 2.11E-39 C5 CCNI 0.28527423 0.815 0.426 3.86E-39 C5 SNRPE 0.341705054 0.873 0.459 1.06E-38 C5 SSBP1 0.302760786 0.805 0.423 1.68E-38 C5 CIRBP 0.296194011 0.845 0.471 2.76E-38 C5 CKLF 0.257054466 0.617 0.285 4.59E-38 C5 RAD21 0.258722673 0.742 0.364 1.32E-37 C5 MANF 0.395522212 0.697 0.349 6.05E-37 C5 RPL37A 0.270480871 1 0.983 1.84E-35 C5 RPL27A 0.273652886 1 0.989 3.94E-35 C5 SNRPD1 0.322112798 0.89 0.492 6.10E-35 C5 SEC11A 0.264727046 0.805 0.385 7.26E-35 C5 RPL23A 0.277515712 1 0.943 7.81E-35 C5 PHB 0.309475288 0.815 0.47 2.09E-34 C5 DYNLRB1 0.251225493 0.829 0.456 4.45E-34 C5 PSMB3 0.294341443 0.904 0.492 5.20E-34 C5 SKP1 0.295971548 0.904 0.525 7.01E-34 C5 NDUFA4 0.361459193 0.977 0.689 4.43E-33 C5 H3F3A 0.331096505 0.995 0.815 6.08E-32 C5 KRTCAP2 0.252446722 0.885 0.498 1.59E-30 C5 PSMB1 0.272775946 0.871 0.464 5.77E-30 C5 YWHAZ 0.338866811 0.96 0.645 1.17E-29 C5 SLC25A5 0.314176 0.93 0.564 1.56E-29 C5 HSBP1 0.259600315 0.864 0.48 1.64E-29 C5 STMN1 0.373057507 0.462 0.203 3.24E-29 C5 SDF2L1 0.312839315 0.683 0.375 4.58E-29 C5 LAMTOR4 0.256415961 0.904 0.574 1.50E-27 C5 COMMD6 0.265453028 0.925 0.564 2.48E-27 C5 COX5A 0.325219773 0.951 0.629 7.87E-27 C5 PEBP1 0.317877207 0.932 0.635 8.90E-27 C5 HMGB1 0.307429385 0.979 0.711 1.60E-26 C5 CYCS 0.322740024 0.915 0.601 5.55E-26 C5 H2AFZ 0.339250759 0.739 0.418 1.51E-24 C5 IFI27 0.342840075 0.988 0.82 3.82E-24 C5 SLC25A3 0.340644592 0.908 0.586 4.90E-24 C5 HNRNPA1 0.300112485 0.977 0.725 7.51E-24 C5 CYC1 0.251663082 0.923 0.627 1.64E-23 C5 USMG5 0.29034595 0.946 0.701 3.08E-23 C5 REG1A 0.943285772 0.423 0.197 1.28E-22 C5 TSPAN8 0.3695604 0.972 0.772 2.95E-22 C5 DBI 0.282827706 0.939 0.656 4.12E-22 C5 TUBB4B 0.380931049 0.873 0.599 6.83E-21 C5 GDF15 0.25147878 0.655 0.367 1.61E-20 C5 CALR 0.272886416 0.911 0.645 2.71E-16 C5 HSPA5 0.256147182 0.824 0.535 5.99E-15 C5

FOS 0.448309938 0.897 0.802 1.43E-13 C5 KLF6 0.258128887 0.789 0.615 1.13E-05 C5

Zhang M, et al. Gut 2021; 70:1–12. doi: 10.1136/gutjnl-2019-320368