Antibacterial Or Bactericide Comprising 2-Aminothiazole Derivative and Salts Thereof
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E-™ II 1 1 INI II IMI 1 1 II II I Mil II I II European Patent Office Office europeen des brevets (11) EP 0 790 057 A1 (12) EUROPEAN PATENT APPLICATION published in accordance with Art. 158(3) EPC (43) Date of publication: (51) Int. CI.6: A61 K 31/425, C07D 277/40, 20.08.1997 Bulletin 1997/34 C07D 277/42, C07D 277/44, (21) Application number: 95938022.1 C07D 41 7/04 (22) Date of filing: 16.11.1995 (86) International application number: PCT/JP95/02347 (87) International publication number: WO 96/16650 (06.06.1996 Gazette 1996/26) (84) Designated Contracting States: • YOSHIDA, Toshio CH DE FR GB IE LI Hisamitsu Pharmaceutical Co., Inc. Saga 841 (JP) (30) Priority: 29.11.1994 JP 317737/94 . ITOYAMA, Toshio, 22.1 2.1 994 JP 335388/94 Tsukuba Laboratory, 1-chome Tsukuba-shi, Ibaraki 305 (JP) (71) Applicant: . TANIGUCHI, Yasuaki HISAMITSU PHARMACEUTICAL CO. INC. Hisamitsu Pharm Co., Inc. Tosu-shi Saga 841 (JP) Saga 841 (jP) (72) Inventors: (74) Representative: Modiano, Guido, Dr.-lng. et al • HASHIGUCHI, Terushi Modiano, Josif, Pisanty & Staub, Hisamitsu Pharmac. Co., Inc. Baaderstrasse 3 Tosu-shi Saga 841 (JP) 80469 Munchen (DE) (54) ANTIBACTERIAL OR BACTERICIDE COMPRISING 2-AMINOTHIAZOLE DERIVATIVE AND SALTS THEREOF (57) An antibacterial or bactericide comprising a 2- aminothiazole derivative represented by general for- mula (I) or a salt thereof, wherein R1 and R2 represent each hydrogen, halogeno, lower alkyl, lower cycloalkyl, (un)substituted phenyl, thiophene, benzoyl, benzoylme- thyl, optionally substituted benzyl, p-pivoloyloxyphenyl, - COOR3 (wherein R3 represents hydrogen or lower alkyl) or -CH2COOR4 (wherein R4 represents hydrogen, lower alkyl or optionally substituted benzyl); and A1 and A2 represent each hydrogen, lower alkanesulfonyl, hal- ogenated lower alkanesulfonyl, optionally substituted phenyl, substituted benzoyl, substituted benzyl, (un)substituted benzenesulfonyl, (un)substituted lower alkanoyl, amidino, -CO-R5 (wherein R5 represents lower alkyl, optionally substituted phenyl, -(CH2)m- ,,_ COOH (wherein m represents an integer of 1 to 5), - <^ (CH2)n-NH-R6 (wherein n represents an integer of 1 to and ^ 5, R6 represents hydrogen, tert-butoxycarbonyl or If) benzyloxycarbonyl) or -(CH2)Q-R7 (wherein Q repre- O sents an integer of 0 to 5, and R7 represents lower O alkoxy, optionally substituted phenyl, optionally substi- tuted pyridyl or cyclic amino), or A1 and A2 are com- bined with each other to represent cyclic amino. Q_ LU Printed by Rank Xerox (UK) Business Services 2.14.12/3.4 EP 0 790 057 A1 Description Technical Field 5 This invention relates to an antibacterial preparation or a bactericide, comprising a 2-aminothiazole derivative and a salt thereof. The term "bactericide" used herein connotes disinfectants. Background Art 10 Prior art will be described. At the outset, thiazoles having a trifluoromethanesulfonylamino group at the 2-position are described in U.S. Patent Nos. 3,923,810 and 3,923,811. Japanese Pat. Appln. Laid-Open Gazettes Nos. Sho 64- 40474 (40474/89) and Sho 64-75475 (75475/89) describe thiazole derivatives having anti-inflammatory action and analgesic action. Phenyl pivalate derivatives are described as an elastase inhibitor in U.S. Patent No. 4,801,610 and Japanese Pat. Appln. Laid-Open Gazette No. Hei 3-20253 (20253/91). Further, the compounds or part of the com- 15 pounds of this invention are described also in Japanese Pat. Appln. Laid-Open Gazettes Nos. Hei 3-173876 (173876/91) and Hei 5-70446 (70446/93). However, the antibacterial action or bactericidal action of the compounds of this invention is not disclosed at all, nor is it suggested. Disclosure of the Invention 20 An object of this invention is to provide an antibacterial preparation or a bactericide each of which comprises a com- prising a 2-aminothiazole derivative and a salt thereof, exhibits a tendency of low bacterial tolerance thereto and low toxicity and has antibacterial activity or bactericidal activity, and the object is also to provide a pharmaceutical compris- ing the antibacterial preparation or the bactericide. 25 This invention relates to a novel antibacterial agent or bactericide comprising 2-aminothiazole derivatives and salts thereof as effective ingredients. More specifically, this invention relates to 2-aminothiazole derivatives represented by the following general formula (I) and their salts useful as pharmaceutical preparations: 30 wherein R1 and R2 each represent a hydrogen atom; a halogen atom; a lower alkyl, lower cycloalkyl, substituted or unsubstituted phenyl, thiophene, benzoyl, benzoylmethyl, benzyl or substituted benzyl or p-pivaloyloxyphenyl group; 40 -COOR3 wherein R3 is a hydrogen atom, a lower alkyl group; and -CH2COOR4 wherein R4 is a hydrogen atom or a lower alkyl, benzyl or substituted benzyl group; and A1 and A2 each represent a hydrogen atom; a lower alkanesulfonyl, halo lower alkanesulfonyl, phenyl or substituted phenyl, substituted benzoyl, substituted benzyl, substituted or unsub- stituted benzenesulfonyl, substituted or unsubstituted lower alkanoyl or amidino group; -CO-R5 wherein R5 is a lower alkyl, phenyl or substituted phenyl group, -(CH2)m-COOH wherein m is an integer of 1 to 5, or -(CH2)n-NH-R6 wherein 45 n is an integer of 1 to 5 and R6 is a hydrogen atom or a tert-butoxycarbonyl, benzyloxycarbonyl group; and -(CH2)Q-R7 wherein Q is an integer of 0 to 5 and R7 is a lower alkoxy, phenyl or substituted phenyl, pyridyl or substituted pyridyl, cyclic amino group; or A1 and A2 may combine with each other to form a cyclic amino group. The general formula (I) will be described in detail. The halogen atoms include fluorine, chlorine, bromine and iodine. The lower alkyl groups include C1 - C8 alkyl groups such as methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl so and tert-butyl groups. The lower cycloalkyl groups include C3 - C6 cycloalkyl groups such as cyclopropyl, cyclobutyl, cyclopentane and cyclohexane groups. The lower alkoxy groups include C1 - C6 alkoxy groups such as methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, iso-butoxy and tert-butoxy groups. The lower alkanesulfonyl groups include C1 - C4 alkanesulfonyl groups such as methanesulfonyl, ethanesulfonyl, n-propanesulfonyl, iso-propanesulfonyl n-butanesulfo- nyl groups, iso-butanesulfonyl and tert-butanesulfonyl groups. The halo lower alkanesulfonyl group is a halo lower 55 alkanesulfonyl group substituted by one or a plurality of halogen atoms, and the substituted alkanesulfonyl groups include mono-, di- or tri-fluoromethanesulfonyl, chloromethanesulfonyl, bromomethanesulfonyl, fluoroethanesulfonyl, chloroethanesulfonyl and bromoethanesulfonyl groups. The substituted or unsubstituted lower alkanoyl group is a C1 - C4 halo lower alkanoyl group substituted by an amino group or one to three halogen atoms, and the alkanoyl groups so substituted or not include aminoacetyl, monofluoroacetyl, difluoroacetyl, trifluoroacetyl, monochloroacetyl, dichloro- 2 EP 0 790 057 A1 acetyl, trichloroacetyl, monofluoropropionyl, difluoropropionyl and trifluoropropionyl groups. The lower alkanoyloxy groups include Ci - C6 alkanoyloxy groups such as acetyl, propionyl, butyryl, valeryl and pivaloyl groups. The cyclic amino groups include 5-or 6-membered cyclic amino groups optionally containing a nitrogen or oxygen atom, such as piperidino, pyrrolidine, morpholino, piperazino and pipecolino groups (the cyclic amino groups may be further substi- 5 tuted by a halogen atom, a lower alkyl group or the like). The substituents in the substituted phenyl, substituted benzyl, substituted pyridyl groups and substituted benzenesulfonyl groups refer to those substituted at their optional one to three positions by lower alkyl groups, halogen atoms, hydroxyl groups, nitro groups, phenyl groups, trifluoromethyl groups, lower alkoxy groups, halo lower alkoxy groups substituted by one or a plurality of halogen atoms, lower alkanesulfonyl groups, halo lower alkanesulfonyl groups, amino groups, Ci - C6 di-lower-alkylamino groups such as 10 dimethylamino, diethylamino, di-n-propylamino and di-n-butylamino groups, Ci - C6 lower alkylsulphenyl groups such as methylsulphenyl, ethylsulphenyl, n-propylsulphenyl, iso-propylsulphenyl, n-butylsulphenyl and tert-butylsulphenyl groups, C2 - C6 lower alkanoylamino groups such as acetylamino, propionylamino, butyrylamino, iso-butyrylamino, valerylamino and pivaloylamino groups, lower alkanoyloxy groups, Ci -C4 lower mercapto groups such as methylthio, ethylthio, n-propylthio, iso-propylthio, n-butylthio, iso-butylthio and tert-butylthio groups, hydroxyl groups, acetic groups, 15 Ci - C4 acetic ester groups such as methyl acetate, ethyl acetate, propyl acetate and butyl acetate groups, Ci - C4 gly- colic ester groups such as methyl glycolate, ethyl glycolate, propyl glycolate and butyl glycolate groups, or the like; and also refer to -COOR4 and -CH2COOR4 wherein R4 is as defined above. Pharmaceutically acceptable salts thereof include, but are not limited to, inorganic acids such as hydrochloric acid, sulfuric acid, nitric acid and phosphoric acid; organic acids such as maleic acid, fumaric acid, oxalic acid, succinic acid, 20 malonic acid, lactic acid, citric acid, methanesulfonic acid, benzenesulfonic acid and acetic acid; inorganic salts, for example, alkali metal salts such as lithium salts, sodium salts and potassium salts, alkaline earth metal salts such as calcium salts and magnesium salts, and ammonium salts; and organic salts such as triethylamine salts, ethanolamine salts, triethanolamine salts and dicyclohexylamine