January 31, 2017 u vol. 114 u no. 5

From the Cover

932 Rise of gender inequality in China 810 Ice and organic crystal formation 915 Family member deaths, bereavement, and race 998 Improving vaccine immunogen design 1165 Parkinson’s disease and protein

Contents

THIS WEEK IN PNAS Cover image: Pictured are 783 In This Issue archaeological excavations at the Xiyasi Cemetery in China. Yu Dong et al. LETTERS (ONLINE ONLY) analyzed human skeletal remains from China’s Bronze Age Eastern Zhou E656 Polymeric phase V of carbon dioxide has not been recovered at ambient Dynasty, which lasted from 771 to 221 pressure and has a unique structure BC, and documented differences in diet, Fre´de´ric Datchi, Mathieu Moog, Fabio Pietrucci, and A. Marco Saitta health, and funerary wealth between E658 Reply to Datchi et al.: Recovered phase CO2-V at low temperature and a newly males and females that were not evident predicted 3D-extended CO2 phase in earlier Neolithic agricultural Hanyu Liu, Xue Yong, Yansun Yao, John S. Tse, and Choong-Shik Yoo communities from the same region. These findings suggest that gender SCIENCE AND CULTURE—How science intersects with culture inequality emerged in China during the Bronze Age. See the article by Yu Dong 785 The brain within buildings et al. on pages 932–937. Image courtesy Amber Dance of Wenquan Fan. INNER WORKINGS—An over-the-shoulder look at scientists at work 788 Bacteria work together to survive Earth’s depths Sandeep Ravindran

RETROSPECTIVE 791 Deborah S. Jin 1968–2016: Trailblazer of ultracold science Kang-Kuen Ni, Markus Greiner, and Silke Ospelkaus

PROFILE 793 Profile of Eugene V. Koonin Paul Gabrielsen See Inaugural Article on page 11399 in issue 41 of volume 113

COMMENTARIES 797 Crystals creeping out of cracks Thomas Koop See companion article on page 810 800 Why death haunts black lives Douglas S. Massey See companion article on page 915

Free online through the PNAS open access option. PNAS u January 31, 2017 u vol. 114 u no. 5 u iii–viii Downloaded by guest on October 1, 2021 803 Combating Parkinson’s disease-associated toxicity by 881 Large 14C excursion in 5480 BC indicates an abnormal modulating proteostasis sun in the mid-Holocene Yangshin Park and Quyen Q. Hoang Fusa Miyake, A. J. Timothy Jull, Irina P. Panyushkina, Lukas See companion article on page 1165 Wacker, Matthew Salzer, Christopher H. Baisan, Todd Lange, Richard Cruz, Kimiaki Masuda, and Toshio Nakamura PNAS PLUS ENGINEERING 805 Significance Statements E820 Defining recovery neurobiology of injured spinal cord Brief statements written by the authors about the significance of their by synthetic matrix-assisted hMSC implantation papers. Alexander E. Ropper, Devang K. Thakor, InBo Han, Dou Yu, Xiang Zeng, Jamie E. Anderson, Zaid Aljuboori, Soo-Woo Kim, PHYSICAL SCIENCES Hongjun Wang, Richard L. Sidman, Ross D. Zafonte, and Yang D. Teng APPLIED PHYSICAL SCIENCES 885 Dynamic assembly of ultrasoft colloidal networks 810 Observing the formation of ice and organic crystals in enables cell invasion within restrictive active sites fibrillar polymers James M. Campbell, Fiona C. Meldrum, Alison M. Douglas, Alexandros A. Fragkopoulos, Michelle K. and Hugo K. Christenson Gaines, L. Andrew Lyon, Alberto Fernandez-Nieves, See Commentary on page 797 and Thomas H. Barker 816 Spectroscopic evidence for bulk-band inversion and three-dimensional massive Dirac fermions in ZrTe5 PHYSICS Zhi-Guo Chen (谌志国),R.Y.Chen,R.D.Zhong,JohnSchneeloch, 891 Revealing nonclassicality beyond Gaussian states via C. Zhang, Y. Huang, Fanming Qu, Rui Yu, Q. Li, G. D. Gu, a single marginal distribution and N. L. Wang Jiyong Park, Yao Lu, Jaehak Lee, Yangchao Shen, Kuan Zhang, 822 Zero-index structures as an alternative platform for Shuaining Zhang, Muhammad Suhail Zubairy, Kihwan Kim, quantum optics and Hyunchul Nha In˜igo Liberal and Nader Engheta

CHEMISTRY SOCIAL SCIENCES 828 Eight-coordinate fluoride in a silicate double-four-ring Maarten G. Goesten, Roald Hoffmann, F. Matthias Bickelhaupt, ANTHROPOLOGY and Emiel J. M. Hensen 897 Modeling the role of voyaging in the coastal spread of 834 High Coulombic efficiency aluminum-ion battery using the Early Neolithic in the West Mediterranean an AlCl3-urea ionic liquid analog electrolyte Neus Isern, Joa˜o Zilha˜o, Joaquim Fort, Michael Angell, Chun-Jern Pan, Youmin Rong, Chunze Yuan, and Albert J. Ammerman Meng-Chang Lin, Bing-Joe Hwang, and Hongjie Dai

840 Catalytic oxidation of Li2S on the surface of metal ECONOMIC SCIENCES sulfides for Li−S batteries 903 Infrastructure mitigates the sensitivity of child Guangmin Zhou, Hongzhen Tian, Yang Jin, Xinyong Tao, Bofei growth to local agriculture and rainfall in Liu, Rufan Zhang, Zhi Wei Seh, Denys Zhuo, Yayuan Liu, Jie Sun, Nepal and Uganda Jie Zhao, Chenxi Zu, David Sichen Wu, Qianfan Zhang, Gerald E. Shively and Yi Cui

846 Thermal-driven domain and cargo transport in ENVIRONMENTAL SCIENCES lipid membranes 852 Holocene ENSO-related cyclic storms recorded by Emma L. Talbot, Lucia Parolini, Jurij Kotar, Lorenzo Di Michele, and Pietro Cicuta magnetic minerals in speleothems of central China Zongmin Zhu, Joshua M. Feinberg, Shucheng Xie, Mark D. Bourne, Chunju Huang, Chaoyong Hu, and Hai Cheng EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES 852 Holocene ENSO-related cyclic storms recorded by PSYCHOLOGICAL AND COGNITIVE SCIENCES magnetic minerals in speleothems of central China Zongmin Zhu, Joshua M. Feinberg, Shucheng Xie, Mark D. 909 Utility-value intervention with parents increases Bourne, Chunju Huang, Chaoyong Hu, and Hai Cheng students’ STEM preparation and career pursuit Christopher S. Rozek, Ryan C. Svoboda, Judith M. Harackiewicz, 858 Iron isotopes reveal distinct dissolved iron sources and Chris S. Hulleman, and Janet S. Hyde pathways in the intermediate versus deep Southern Ocean 1153 Scene-selective coding by single neurons in the human Cyril Abadie, Francois Lacan, Amandine Radic, Catherine parahippocampal cortex Pradoux, and Franck Poitrasson Florian Mormann, Simon Kornblith, Moran Cerf, Matias J. Ison, Alexander Kraskov, Michelle Tran, Simeon Knieling, Rodrigo 864 Elemental sulfur aerosol-forming mechanism Quian Quiroga, Christof Koch, and Itzhak Fried Manoj Kumar and Joseph S. Francisco 870 Hydrogen isotope fractionation in methane plasma SOCIAL SCIENCES Franc¸ois Robert, Sylvie Derenne, Guillaume Lombardi, Khaled E727 Selection against variants in the genome associated Hassouni, Armelle Michau, Peter Reinhardt, Re´mi Duhamel, Adriana Gonzalez, and Kasia Biron with educational attainment Augustine Kong, Michael L. Frigge, Gudmar Thorleifsson, 875 Selenium isotopes record extensive marine suboxia Hreinn Stefansson, Alexander I. Young, Florian Zink, Gudrun A. during the Great Oxidation Event Jonsdottir, Aysu Okbay, Patrick Sulem, Gisli Masson, Daniel F. Michael A. Kipp, Eva E. Stu¨eken, Andrey Bekker, Gudbjartsson, Agnar Helgason, Gyda Bjornsdottir, Unnur and Roger Buick Thorsteinsdottir, and Kari Stefansson

iv u www.pnas.org Contents Downloaded by guest on October 1, 2021 915 Death of family members as an overlooked source of 950 Repair shielding of platinum-DNA lesions in testicular racial disadvantage in the United States germ cell tumors by high-mobility group box protein Debra Umberson, Julie Skalamera Olson, Robert Crosnoe, Hui 4 imparts cisplatin hypersensitivity Liu, Tetyana Pudrovska, and Rachel Donnelly Samuel G. Awuah, Imogen A. Riddell, and Stephen J. Lippard See Commentary on page 800 956 Role of CCT chaperonin in the disassembly of mitotic checkpoint complexes SUSTAINABILITY SCIENCE Sharon Kaisari, Danielle Sitry-Shevah, Shirly Miniowitz-Shemtov, 921 Fragility of the provision of local public goods to Adar Teichner, and Avram Hershko private and collective risks 962 Molecular imaging of biological systems with a Juan-Camilo Ca´rdenas, Marco A. Janssen, Manita Ale, Ram clickable dye in the broad 800- to 1,700-nm Bastakoti, Adriana Bernal, Juthathip Chalermphol, Yazhen near-infrared window Gong, Hoon Shin, Ganesh Shivakoti, Yibo Wang, Shoujun Zhu, Qinglai Yang, Alexander L. Antaris, Jingying Yue, and John M. Anderies Zhuoran Ma, Huasen Wang, Wei Huang, Hao Wan, Joy Wang, 926 Field-scale experiments reveal persistent yield gaps in Shuo Diao, Bo Zhang, Xiaoyang Li, Yeteng Zhong, Kuai Yu, low-input and organic cropping systems Guosong Hong, Jian Luo, Yongye Liang, and Hongjie Dai Alexandra N. Kravchenko, Sieglinde S. Snapp, 968 Helical structure, stability, and dynamics in human and G. Philip Robertson apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry Palaniappan S. Chetty, Leland Mayne, Sissel Lund-Katz, BIOLOGICAL SCIENCES S. Walter Englander, and Michael C. Phillips 974 Biosynthesis of the microtubule-destabilizing AGRICULTURAL SCIENCES diterpene pseudolaric acid B from golden larch 926 Field-scale experiments reveal persistent yield gaps in involves an unusual diterpene synthase low-input and organic cropping systems Sibongile Mafu, Prema Sambandaswami Karunanithi, Teresa Alexandra N. Kravchenko, Sieglinde S. Snapp, Ann Palazzo, Bronwyn Lee Harrod, Selina Marakana Rodriguez, and G. Philip Robertson Iris Natalie Mollhoff, Terrence Edward O’Brien, Shen Tong, Oliver Fiehn, Dean J. Tantillo, Jo¨rg Bohlmann, ANTHROPOLOGY and Philipp Zerbe 932 Shifting diets and the rise of male-biased inequality on 980 Conserved GTPase LepA (Elongation Factor 4) the Central Plains of China during Eastern Zhou functions in biogenesis of the 30S subunit Yu Dong, Chelsea Morgan, Yurii Chinenov, Ligang Zhou, of the 70S ribosome Wenquan Fan, Xiaolin Ma, and Kate Pechenkina Michelle R. Gibbs, Kyung-Mee Moon, Menglin Chen, Rohan Balakrishnan, Leonard J. Foster, and Kurt Fredrick

APPLIED BIOLOGICAL SCIENCES 986 Structure and activation of C1, the complex initiating the classical pathway of the complement cascade 938 Drivers of Rift Valley fever epidemics in Madagascar Renaud Lancelot, Marina Be´ral, Vincent Michel Simon A. Mortensen, Bjoern Sander, Rasmus K. Jensen, Jan Rakotoharinome, Soa-Fy Andriamandimby, Jean-Michel Skov Pedersen, Monika M. Golas, Jens C. Jensenius, Annette G. He´raud, Caroline Coste, Andrea Apolloni, Ce´cile Hansen, Steffen Thiel, and Gregers R. Andersen Squarzoni-Diaw, Ste´phane de La Rocque, Pierre B. H. BIOPHYSICS AND COMPUTATIONAL BIOLOGY Formenty, Je´re´my Bouyer, G. R. William Wint, and Eric Cardinale E689 Kinetic assay shows that increasing red cell volume could be a treatment for sickle cell disease 944 Biophysical properties of the clinical-stage Quan Li, Eric R. Henry, James Hofrichter, Jeffrey F. Smith, Troy antibody landscape Cellmer, Emily B. Dunkelberger, Belhu B. Metaferia, Stacy Tushar Jain, Tingwan Sun, Ste´phanie Durand, Amy Hall, Nga Jones-Straehle, Sarah Boutom, Garrott W. Christoph, Terri H. Rewa Houston, Juergen H. Nett, Beth Sharkey, Beata Wakefield, Mary E. Link, Dwayne Staton, Erica R. Vass, Jeffery L. Bobrowicz, Isabelle Caffry, Yao Yu, Yuan Cao, Heather Miller, Matthew M. Hsieh, John F. Tisdale, and William A. Eaton Lynaugh, Michael Brown, Hemanta Baruah, Laura T. Gray, Eric M. Krauland, Yingda Xu, Maximiliano Va´squez, E697 Structure of eukaryotic CMG helicase at a replication and K. Dane Wittrup fork and implications to replisome architecture and origin initiation Roxana Georgescu, Zuanning Yuan, Lin Bai, Ruda de Luna BIOCHEMISTRY Almeida Santos, Jingchuan Sun, Dan Zhang, Olga Yurieva, E660 Elucidating the mechanism of fluorinated extender Huilin Li, and Michael E. O’Donnell unit loading for improved production of 992 In situ structure of trypanosomal ATP synthase dimer fluorine-containing polyketides reveals a unique arrangement of catalytic subunits Omer Ad, Benjamin W. Thuronyi, and Michelle C. Y. Chang Alexander W. Mu¨hleip, Caroline E. Dewar, Achim Schnaufer, E669 Unlocking Tn3-family transposase activity in Werner Ku¨hlbrandt, and Karen M. Davies vitro unveils an asymetric pathway for 998 One-step design of a stable variant of the malaria transposome assembly invasion protein RH5 for use as a vaccine immunogen Emilien Nicolas, Ce´dric A. Oger, Nathan Nguyen, Michae¨l Ivan Campeotto, Adi Goldenzweig, Jack Davey, Lea Barfod, Lambin, Amandine Draime, Se´bastien C. Leterme, Michael Jennifer M. Marshall, Sarah E. Silk, Katherine E. Wright, Simon J. Chandler, and Bernard F. J. Hallet Draper, Matthew K. Higgins, and Sarel J. Fleishman E679 Recognition of protein-linked glycans as a determinant 1003 Do guanidinium and tetrapropylammonium ions of peptidase activity specifically interact with aromatic amino acid side chains? Ilit Noach, Elizabeth Ficko-Blean, Benjamin Pluvinage, Bei Ding, Debopreeti Mukherjee, Jianxin Chen, and Feng Gai Christopher Stuart, Meredith L. Jenkins, Denis Brochu, Nakita Buenbrazo, Warren Wakarchuk, John E. Burke, Michel Gilbert, 1009 Tuning the ion selectivity of two-pore channels and Alisdair B. Boraston Jiangtao Guo, Weizhong Zeng, and Youxing Jiang

Contents PNAS u January 31, 2017 u vol. 114 u no. 5 u v Downloaded by guest on October 1, 2021 1015 α-Actinin/ interaction: A dynamic and 1063 The NBS-LRR architectures of plant R-proteins mechanically stable cluster of bonds in and metazoan NLRs evolved in the muscle Z-disk independent events Marco Grison, Ulrich Merkel, Julius Kostan, Kristina Jonathan M. Urbach and Frederick M. Ausubel  Djinovic-Carugo, and Matthias Rief 1069 Ontogenetic and life history trait changes associated 1021 Crystal structure of Pistol, a class of with convergent ecological specializations in extinct self-cleaving ribozyme ungulate mammals Laura A. Nguyen, Jimin Wang, and Thomas A. Steitz Helder Gomes Rodrigues, Anthony Herrel, and Guillaume Billet 1075 Evolution of antibiotic resistance is linked to any CELL BIOLOGY genetic mechanism affecting bacterial duration E707 β-Catenin haploinsufficiency promotes mammary of carriage tumorigenesis in an ErbB2-positive basal breast Sonja Lehtinen, Franc¸ois Blanquart, Nicholas J. Croucher, Paul cancer model Turner, Marc Lipsitch, and Christophe Fraser Bui Tung, Babette Schade, Robert D. Cardiff, Olulanu H. Aina, 1081 Comparative genomics reveals convergent evolution Virginie Sanguin-Gendreau, and William J. Muller between the bamboo-eating giant and red pandas 1027 Inactivation of the PBRM1 tumor suppressor Yibo Hu, Qi Wu, Shuai Ma, Tianxiao Ma, Lei Shan, Xiao − − amplifies the HIF-response in VHL / clear cell Wang, Yonggang Nie, Zemin Ning, Li Yan, Yunfang Xiu, renal carcinoma and Fuwen Wei Wenhua Gao, Wei Li, Tengfei Xiao, Xiaole Shirley Liu, 1087 Genomic analysis reveals major determinants of and William G. Kaelin Jr. cis-regulatory variation in Capsella grandiflora 1033 Stress granule-associated protein G3BP2 regulates Kim A. Steige, Benjamin Laenen, Johan Reimega˚rd, Douglas G. breast tumor initiation Scofield, and Tanja Slotte Nisha Gupta, Mark Badeaux, Yiqian Liu, Kamila Naxerova, GENETICS Dennis Sgroi, Lance L. Munn, Rakesh K. Jain, and Igor Garkavtsev E733 Human transposon insertion profiling: Analysis, 1039 TORC1-dependent sumoylation of Rpc82 promotes visualization and identification of somatic RNA polymerase III assembly and activity LINE-1 insertions in ovarian cancer Zuojian Tang, Jared P. Steranka, Sisi Ma, Mark Grivainis, Pierre Chymkowitch, Aure´lie Ngue´a P, Ha˚vard Aanes, Joseph Nemanja Rodic, Cheng Ran Lisa Huang, Ie-Ming Shih, Robertson, Arne Klungland, and Jorrit M. Enserink Tian-Li Wang, Jef D. Boeke, David Fenyo¨, 1045 Human NF-κB repressing factor acts as a and Kathleen H. Burns stress-regulated switch for ribosomal RNA 1093 Establishment of expression-state boundaries by processing and nucleolar homeostasis surveillance Rif1 and Taz1 in fission yeast Marta Coccia, Antonio Rossi, Anna Riccio, Edoardo Trotta, Tea Toteva, Bethany Mason, Yutaka Kanoh, Peter Brøgger, and Maria Gabriella Santoro Daniel Green, Janne Verhein-Hansen, Hisao Masai, and Genevie`ve Thon DEVELOPMENTAL BIOLOGY E717 Transcriptomic, proteomic, and metabolomic IMMUNOLOGY AND INFLAMMATION landscape of positional memory in the E741 Development of chronic allergic responses by caudal fin of zebrafish dampening Bcl6-mediated suppressor activity Jeremy S. Rabinowitz, Aaron M. Robitaille, Yuliang Wang, in memory T helper 2 cells Catherine A. Ray, Ryan Thummel, Haiwei Gu, Danijel Djukovic, Takashi Ogasawara, Masahiko Hatano, Hisae Satake, Jun Ikari, Daniel Raftery, Jason D. Berndt, and Randall T. Moon Toshibumi Taniguchi, Nobuhide Tsuruoka, Haruko 1051 Measurement of cortical elasticity in Drosophila Watanabe-Takano, Lisa Fujimura, Akemi Sakamoto, Hirokuni Hirata, Kumiya Sugiyama, Yasutsugu Fukushima, Susumu melanogaster embryos using ferrofluids Nakae, Kenji Matsumoto, Hirohisa Saito, Takeshi Fukuda, Konstantin Doubrovinski, Michael Swan, Oleg Polyakov, Kazuhiro Kurasawa, Koichiro Tatsumi, Takeshi Tokuhisa, and Eric F. Wieschaus and Masafumi Arima 1057 Molecular mechanism underlying juvenile E751 Ornithine decarboxylase regulates M1 macrophage hormone-mediated repression of precocious activation and mucosal inflammation via – larval adult metamorphosis histone modifications Takumi Kayukawa, Akiya Jouraku, Yuka Ito, and Tetsuro Shinoda Dana M. Hardbower, Mohammad Asim, Paula B. Luis, Kshipra Singh, Daniel P. Barry, Chunying Yang, Meredith A. Steeves, ENVIRONMENTAL SCIENCES John L. Cleveland, Claus Schneider, M. Blanca Piazuelo, Alain P. 858 Iron isotopes reveal distinct dissolved iron sources and Gobert, and Keith T. Wilson pathways in the intermediate versus deep E761 Mitochondrial activation chemicals synergize Southern Ocean with surface receptor PD-1 blockade for Cyril Abadie, Francois Lacan, Amandine Radic, Catherine T cell-dependent antitumor activity Pradoux, and Franck Poitrasson Kenji Chamoto, Partha S. Chowdhury, Alok Kumar, Kazuhiro Sonomura, Fumihiko Matsuda, Sidonia Fagarasan, EVOLUTION and Tasuku Honjo E727 Selection against variants in the genome associated 1099 Modification of host dendritic cells by microchimerism- with educational attainment derived extracellular vesicles generates Augustine Kong, Michael L. Frigge, Gudmar Thorleifsson, split tolerance Hreinn Stefansson, Alexander I. Young, Florian Zink, Gudrun A. William Bracamonte-Baran, Jonathan Florentin, Ying Zhou, Ewa Jonsdottir, Aysu Okbay, Patrick Sulem, Gisli Masson, Daniel F. Jankowska-Gan, W. John Haynes, Weixiong Zhong, Todd V. Gudbjartsson, Agnar Helgason, Gyda Bjornsdottir, Unnur Brennan, Partha Dutta, Frans H. J. Claas, Jon J. van Rood, Thorsteinsdottir, and Kari Stefansson and William J. Burlingham

vi u www.pnas.org Contents Downloaded by guest on October 1, 2021 1105 Phylogenetic analysis of the human antibody 1135 Multi-institute analysis of carbapenem resistance repertoire reveals quantitative signatures reveals remarkable diversity, unexplained of immune senescence and aging mechanisms, and limited clonal outbreaks Charles F. A. de Bourcy, Cesar J. Lopez Angel, Christopher Gustavo C. Cerqueira, Ashlee M. Earl, Christoph M. Ernst, Vollmers, Cornelia L. Dekker, Mark M. Davis, Yonatan H. Grad, John P. Dekker, Michael Feldgarden, and Stephen R. Quake Sine´ad B. Chapman, Joa˜o L. Reis-Cunha, Terrance P. Shea, 1111 Trogocytosis of peptide–MHC class II complexes from Sarah Young, Qiandong Zeng, Mary L. Delaney, Diane Kim, Ellena M. Peterson, Thomas F. O’Brien, Mary Jane Ferraro, dendritic cells confers antigen-presenting ability David C. Hooper, Susan S. Huang, James E. Kirby, Andrew B. on basophils Onderdonk, Bruce W. Birren, Deborah T. Hung, Lisa A. Cosimi, Kensuke Miyake, Nozomu Shiozawa, Toshihisa Nagao, Jennifer R. Wortman, Cheryl I. Murphy, and William P. Hanage Soichiro Yoshikawa, Yoshinori Yamanishi, and Hajime Karasuyama 1141 Prion replication without host adaptation during interspecies transmissions 1117 COX2/mPGES1/PGE2 pathway regulates PD-L1 Jifeng Bian, Vadim Khaychuk, Rachel C. Angers, Natalia expression in tumor-associated macrophages Ferna´ndez-Borges, Enric Vidal, Crystal Meyerett-Reid, Sehun and myeloid-derived suppressor cells Kim, Carla L. Calvi, Jason C. Bartz, Edward A. Hoover, Umberto Victor Prima, Lyudmila N. Kaliberova, Sergey Kaliberov, David T. Agrimi, Ju¨rgen A. Richt, Joaquı´n Castilla, and Glenn C. Telling Curiel, and Sergei Kusmartsev 1147 Hepatitis E virus ORF3 is a functional ion channel required for release of infectious particles MEDICAL SCIENCES Qiang Ding, Brigitte Heller, Juan M. V. Capuccino, Bokai Song, E771 Atrial natriuretic peptide regulates adipose tissue Ila Nimgaonkar, Gabriela Hrebikova, Jorge E. Contreras, accumulation in adult atria and Alexander Ploss Nadine Suffee, Thomas Moore-Morris, Patrick Farahmand, NEUROSCIENCE Catherine Ru¨cker-Martin, Gilles Dilanian, Magali Fradet, Daigo Sawaki, Genevie`ve Derumeaux, Pascal LePrince, Karine E820 Defining recovery neurobiology of injured spinal cord Cle´ment, Isabelle Dugail, Michel Puceat, by synthetic matrix-assisted hMSC implantation and Ste´phane N. Hatem Alexander E. Ropper, Devang K. Thakor, InBo Han, Dou Yu, 1123 An RNA-based signature enables high specificity Xiang Zeng, Jamie E. Anderson, Zaid Aljuboori, Soo-Woo Kim, Hongjun Wang, Richard L. Sidman, Ross D. Zafonte, detection of circulating tumor cells in and Yang D. Teng hepatocellular carcinoma Mark Kalinich, Irun Bhan, Tanya T. Kwan, David T. Miyamoto, E830 Bilateral recruitment of prefrontal cortex in working Sarah Javaid, Joseph A. LiCausi, John D. Milner, Xin Hong, memory is associated with task demand but not with age Lipika Goyal, Srinjoy Sil, Melissa Choz, Uyen Ho, Ravi Melanie S. Ho¨ller-Wallscheid, Peter Thier, Jo¨rn K. Pomper, Kapur, Alona Muzikansky, Huidan Zhang, David A. Weitz, and Axel Lindner Lecia V. Sequist, David P. Ryan, Raymond T. Chung, E840 Harmonic template neurons in primate auditory cortex Andrew X. Zhu, Kurt J. Isselbacher, David T. Ting, underlying complex sound processing Mehmet Toner, Shyamala Maheswaran, Lei Feng and Xiaoqin Wang and Daniel A. Haber 1129 Stromal cues regulate the pancreatic cancer 1153 Scene-selective coding by single neurons in the human epigenome and metabolome parahippocampal cortex Florian Mormann, Simon Kornblith, Moran Cerf, Matias J. Ison, Mara H. Sherman, Ruth T. Yu, Tiffany W. Tseng, Cristovao M. Alexander Kraskov, Michelle Tran, Simeon Knieling, Rodrigo Sousa, Sihao Liu, Morgan L. Truitt, Nanhai He, Ning Ding, Quian Quiroga, Christof Koch, and Itzhak Fried Christopher Liddle, Annette R. Atkins, Mathias Leblanc, Eric A. Collisson, John M. Asara, Alec C. Kimmelman, Michael Downes, 1159 Amino-terminal domains of kainate receptors and Ronald M. Evans determine the differential dependence on Neto auxiliary subunits for trafficking MICROBIOLOGY Nengyin Sheng, Yun Stone Shi, and Roger A. Nicoll E781 Pathogen-mediated manipulation of arthropod 1165 Nrf2 mitigates LRRK2- and α-synuclein–induced microbiota to promote infection neurodegeneration by modulating proteostasis Nabil M. Abraham, Lei Liu, Brandon Lyon Jutras, Akhilesh K. Gaia Skibinski, Vicky Hwang, Dale Michael Ando, Aaron Daub, Yadav, Sukanya Narasimhan, Vissagan Gopalakrishnan, Alicia K. Lee, Abinaya Ravisankar, Sara Modan, Mariel M. Juliana M. Ansari, Kimberly K. Jefferson, Felipe Cava, Finucane, Benjamin A. Shaby, and Steven Finkbeiner Christine Jacobs-Wagner, and Erol Fikrig See Commentary on page 803 E791 Tissue dual RNA-seq allows fast discovery of 1171 Motor control by precisely timed spike patterns infection-specific functions and riboregulators Kyle H. Srivastava, Caroline M. Holmes, Michiel Vellema, – shaping host pathogen transcriptomes Andrea R. Pack, Coen P. H. Elemans, Ilya Nemenman, Aaron M. Nuss, Michael Beckstette, Maria Pimenova, Carina and Samuel J. Sober Schmu¨hl, Wiebke Opitz, Fabio Pisano, Ann Kathrin Heroven, and Petra Dersch 1177 Transmembrane protein 108 is required for glutamatergic transmission in dentate gyrus E801 Continual renewal and replication of persistent Hui-Feng Jiao, Xiang-Dong Sun, Ryan Bates, Lei Xiong, Lei Leishmania major parasites in concomitantly Zhang, Fang Liu, Lei Li, Hong-Sheng Zhang, Shun-Qi Wang, immune hosts Ming-Tao Xiong, Mihir Patel, Alexis M. Stranahan, Wen-Cheng Michael A. Mandell and Stephen M. Beverley Xiong, Bao-Ming Li, and Lin Mei E811 Antiviral screening identifies adenosine analogs 1183 α-Synuclein binds and sequesters PIKE-L into Lewy targeting the endogenous dsRNA Leishmania bodies, triggering dopaminergic cell death via RNA virus 1 (LRV1) pathogenicity factor AMPK hyperactivation F. Matthew Kuhlmann, John I. Robinson, Gregory R. Seong Su Kang, Zhentao Zhang, Xia Liu, Fredric P. Manfredsson, Bluemling, Catherine Ronet, Nicolas Fasel, Li He, P. Michael Iuvone, Xuebing Cao, Yi E. Sun, Lingjing Jin, and Stephen M. Beverley and Keqiang Ye

Contents PNAS u January 31, 2017 u vol. 114 u no. 5 u vii Downloaded by guest on October 1, 2021 PHYSIOLOGY 1195 Network-based integration of systems genetics data E849 Increased mitochondrial nanotunneling activity, reveals pathways associated with lignocellulosic induced by calcium imbalance, affects biomass accumulation and processing intermitochondrial matrix exchanges Eshchar Mizrachi, Lieven Verbeke, Nanette Christie, Manuela Lavorato, V. Ramesh Iyer, Williams Dewight, Ryan R. Ana C. Fierro, Shawn D. Mansfield, Mark F. Davis, Cupo, Valentina Debattisti, Ludovic Gomez, Sergio De la Erica Gjersing, Gerald A. Tuskan, Marc Van Montagu, Fuente, Yan-Ting Zhao, He´ctor H. Valdivia, Gyo¨rgy Hajno´czky, YvesVandePeer,KathleenMarchal, and Clara Franzini-Armstrong and Alexander A. Myburg E859 Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and PSYCHOLOGICAL AND COGNITIVE SCIENCES contractile activity 1201 Rhythm judgments reveal a frequency asymmetry in Vero´nica Eisner, Ryan R. Cupo, Erhe Gao, Gyo¨rgy Csorda´s, the perception and neural coding of sound synchrony William S. Slovinsky, Melanie Paillard, Lan Cheng, Jessica Ibetti, Magdalena Wojtczak, Anahita H. Mehta, S. R. Wayne Chen, J. Kurt Chuprun, Jan B. Hoek, Walter J. and Andrew J. Oxenham Koch, and Gyo¨rgy Hajno´czky

E869 Competition of calcified calmodulin N lobe and PIP2 to SUSTAINABILITY SCIENCE an LQT mutation site in Kv7.1 channel 903 Infrastructure mitigates the sensitivity of child William Sam Tobelaim, Meidan Dvir, Guy Lebel, Meng Cui, Tal growth to local agriculture and rainfall in Buki, Asher Peretz, Milit Marom, Yoni Haitin, Diomedes E. Nepal and Uganda Logothetis, Joel Alan Hirsch, and Bernard Attali Gerald E. Shively E879 Phosphorylation by PKC and PKA regulate the activity and downstream signaling of WNK4 Maria Castan˜eda-Bueno, Juan Pablo Arroyo, Junhui Zhang, SYSTEMS BIOLOGY Jeremy Puthumana, Orlando Yarborough III, Shigeru Shibata, 1207 RFamide-related peptide-3 (RFRP-3) suppresses Lorena Rojas-Vega, Gerardo Gamba, Jesse Rinehart, sexual maturation in a eusocial mammal and Richard P. Lifton Diana E. Peragine, Martha Pokarowski, Lucia Mendoza-Viveros, 1189 Loss of astrocyte cholesterol synthesis disrupts Ashlyn Swift-Gallant, Hai-Ying M. Cheng, George E. Bentley, neuronal function and alters whole-body metabolism and Melissa M. Holmes Heather A. Ferris, Rachel J. Perry, Gabriela V. Moreira, Gerald I. Shulman, Jay D. Horton, and C. Ronald Kahn CORRECTION (ONLINE ONLY) PLANT BIOLOGY E887 Dynamic PIN-FORMED auxin efflux carrier EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES phosphorylation at the plasma membrane E904 Evolution of South Atlantic density and chemical controls auxin efflux-dependent growth stratification across the last deglaciation Benjamin Weller, Melina Zourelidou, Lena Frank, Ineˆs C. R. Jenny Roberts, Julia Gottschalk, Luke C. Skinner, Victoria L. Barbosa, Astrid Fastner, Sandra Richter, Gerd Ju¨rgens, Ulrich Z. Peck, Sev Kender, Henry Elderfield, Claire Waelbroeck, Natalia Hammes, and Claus Schwechheimer Va´zquez Riveiros, and David A. Hodell E897 TALE-induced bHLH transcription factors that activate a pectate contribute to water soaking in bacterial spot of tomato Allison R. Schwartz, Robert Morbitzer, Thomas Lahaye, and Brian J. Staskawicz ix Subscription Form

viii u www.pnas.org Contents Downloaded by guest on October 1, 2021