TNNC1 Antibody Cat. No.: 18-391

TNNC1 Antibody

Immunohistochemistry of paraffin-embedded human Immunofluorescence analysis of U2OS cells using TNNC1 colon carcinoma using TNNC1 antibody (18-391) at antibody (18-391). Blue: DAPI for nuclear staining. dilution of 1:100 (40x lens).

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human, Mouse

Recombinant fusion containing a sequence corresponding to amino acids 1-160 of IMMUNOGEN: human TNNC1 (NP_003271.1).

TESTED APPLICATIONS: IF, IHC, WB

WB: ,1:500 - 1:2000

APPLICATIONS: IHC: ,1:50 - 1:200

IF: ,1:50 - 1:200

September 28, 2021 1 https://www.prosci-inc.com/tnnc1-antibody-18-391.html POSITIVE CONTROL: 1) Mouse heart

2) Mouse lung

3) Mouse skeletal muscle

PREDICTED MOLECULAR Observed: 16kDa WEIGHT:

Properties

PURIFICATION: Affinity purification

CLONALITY: Polyclonal

ISOTYPE: IgG

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

STORAGE CONDITIONS: Store at -20˚C. Avoid freeze / thaw cycles.

Additional Info

OFFICIAL SYMBOL: TNNC1

TNNC1, CMD1Z, Cardiac C, CMH13, type 1 (slow), TN-C, TNNC, ALTERNATE NAMES: Troponin C, slow, Troponin C1, slow

GENE ID: 7134

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

Troponin is a central regulatory protein of striated muscle contraction, and together with , is located on the filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for BACKGROUND: tropomyosin; and TnC, the protein encoded by this . The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with , the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z.

ANTIBODIES FOR RESEARCH USE ONLY.

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September 28, 2021 2 https://www.prosci-inc.com/tnnc1-antibody-18-391.html