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( 12 ) United States Patent US010127346B2 (12 ) United States Patent (10 ) Patent No. : US 10 , 127 ,346 B2 Dewey et al . (45 ) Date of Patent: Nov . 13 , 2018 (54 ) SYSTEMS AND METHODS FOR Fan et al. Noninvasive diagnosis of fetal aneuploidy by shotgun INTERPRETING A HUMAN GENOME USING sequencing DNA from maternal blood Proceedings of the National A SYNTHETIC REFERENCE SEQUENCE Academy of Sciences USA vol. 16266 - 16271 (2008 ) . * Chen et al. -717A > G polymorphism of human C - reactive protein ( 75 ) Inventors: Frederick Dewey , Redwood City , CA gene associated with coronary heart disease in ethnic Han Chinese : (US ) ; Euan A . Ashley , Menlo Park , CA the Beijing atherosclerosis study Journal of Molecular Medicine (US ) ; Matthew Wheeler, Sunnyvale , vol. 83 , pp . 72 -78 ( 2005 ). * CA (US ) ; Michael Snyder , Stanford , Wheeler et al. 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