HLA Matching Affects Clinical Outcome of Adult Patients
Bone Marrow Transplantation (2009) 44, 571–577 & 2009 Macmillan Publishers Limited All rights reserved 0268-3369/09 $32.00 www.nature.com/bmt ORIGINAL ARTICLE HLA matching affects clinical outcome of adult patients undergoing haematopoietic SCT from unrelated donors: a study from the Gruppo Italiano Trapianto di Midollo Osseo and Italian Bone Marrow Donor Registry R Crocchiolo1,5, F Ciceri1, K Fleischhauer2, R Oneto3, B Bruno3, S Pollichieni4, N Sacchi4, MP Sormani5, R Fanin6, G Bandini7, F Bonifazi7, A Bosi8, A Rambaldi9, PE Alessandrino10, M Falda11 and A Bacigalupo3 1Department of Oncology, Hematology and Bone Marrow Transplantation Unit, S Raffaele Scientific Institute, Milano, Italy; 2Immunogenetics Laboratory, S Raffaele Scientific Institute, Milano, Italy; 3Department of Hemato-Oncology, Division of Hematology, Ospedale San Martino, Genova, Italy; 4Italian Bone Marrow Donor Registry, Ospedale Galliera, Genova, Italy; 5Biostatistics Unit, Department of Health Sciences (DISSAL), University of Genova, Genova, Italy; 6Division of Hematology and Bone Marrow Transplantation, University of Udine, Udine, Italy; 7Institute of Hematology and Clinical Oncology ‘LA Seragnoli’, Bologna, Italy; 8Department of Hematology, University of Florence, Florence, Italy; 9Department of Oncology and Hematology, Division of Hematology, Ospedali Riuniti, Bergamo, Italy; 10Division of Hematology, University of Pavia, Pavia, Italy and 11Division of Hematology, Ospedale San Giovanni Battista, Torino, Italy The importance of HLA donor–recipient matching in Keywords: haematopoietic SCT; haematological malig- unrelated haematopoietic SCT (HSCT) is the subject of nancy; unrelated donor; HLA matching. debate. In this retrospective study, we analyzed 805 adult patients from the Italian Registry receiving HSCT for a haematological malignancy from January 1999 to June 2006 and correlated the degree of HLA matching with Introduction transplant outcome.
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