DOCSLIB.ORG

Brain Ventricle Development in H. Huso (Beluga Sturgeon) Larvae

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Brain Ventricle Development in H. Huso (Beluga Sturgeon) Larvae Brain ventricle development in H. huso (Beluga sturgeon) larvae S. H. Tavighi, Z. Saadatfar, B. Shojaei & M. Behnam Rassouli Anatomical Science International ISSN 1447-6959 Anat Sci Int DOI 10.1007/s12565-015-0307-9 1 23 Your article is protected by copyright and all rights are held exclusively by Japanese Association of Anatomists. This e-offprint is for personal use only and shall not be self- archived in electronic repositories. If you wish to self-archive your article, please use the accepted manuscript version for posting on your own website. You may further deposit the accepted manuscript version in any repository, provided it is only made publicly available 12 months after official publication or later and provided acknowledgement is given to the original source of publication and a link is inserted to the published article on Springer's website. The link must be accompanied by the following text: "The final publication is available at link.springer.com”. 1 23 Author's personal copy Anat Sci Int DOI 10.1007/s12565-015-0307-9 ORIGINAL ARTICLE Brain ventricle development in H. huso (Beluga sturgeon) larvae 1 1 2 3 S. H. Tavighi • Z. Saadatfar • B. Shojaei • M. Behnam Rassouli Received: 10 February 2015 / Accepted: 5 October 2015 Ó Japanese Association of Anatomists 2015 Abstract The development of ventricles in the brain of with age, extending laterally from 6 days old. The con- H. huso (Beluga sturgeon) from 1 to 54 days old is pre- nection of the cerebellar ventricle to the fourth ventricle in sented in this study. The components observed in the the medulla oblongata was visible from 6 days old. Upon 1-day-old ventricular system were the telencephalic, tectal, dividing the ventricular system into three regions (fore- and cerebellar ventricles. These ventricles were not brain, midbrain, and hindbrain), stereological studies per- observed to have any recess or sulcus. They were sur- formed utiizing Cavalieri’s principle indicated that the rounded by copious ependymal and embryonic cells. Two forebrain ventricular region had the smallest volume while different parts were detected in the 6-day-old telencephalic the hindbrain ventricular region had the largest. ventricle: the olfactory and lateral ventricle. The olfactory ventricle was observed as a cranial extension of the Keywords H. huso Á Brain Á Ventricle Á Development Á telencephalic ventricle from 6 days old, as was the inner Stereological cell layer of the olfactory bulb (ic) adjacent to this exten- sion. In the preoptic region, the lateral ventricle was con- Abbreviations nected to the preoptic recess from 15 days old, and this Caq Cerebral aqueduct recess was connected by the interventricular foramen to the cc Central canal third ventricle in the diencephalon. At 6 days old, the third co Commissural organ ventricle in the diencephalon was visible at the caudal part cp Choroid plexus of the lateral ventricle, and the third ventricle had a recess Crc Crown cell near to the inferior lobe of the hypothalamus. At 6 days old, Crv Cerebellar ventricle the tectal ventricle was observed to have bilateral exten- D Diencephalon sions which proceeded to grow with age. The cerebellar ECrv Extension of cerebellar ventricle ventricle, situated between the two lobes of the cerebellum, EM Embryonic cell was observed from 1 day old. The cerebellar ventricle grew EOTV Extension of tectal ventricle ep Ependymal cell Etv Extension of telencephalic ventricle & Z. Saadatfar FV Fourth ventricle [email protected]; [email protected] h Habenula 1 Hypr Hypothalamic recess Department of Basic Science, Faculty of Veterinary Hypv Hypothalamic ventricle Medicine, Ferdowsi University of Mashhad, 91779-48974 Mashhad, Iran ic Inner cell layer of olfactory bulb ivf Interventricular foramen 2 Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, lr Lateral recess of ventricle Iran Lav Lateral ventricle 3 Department of Physiological Science, Faculty of Biology, Ma Mauthner cell Ferdowsi University of Mashhad, Mashhad, Iran MO Medulla oblongata 123 Author's personal copy S. H. Tavighi et al. NAT Anterior tuberal nucleus of its brain ventricles. However, despite all of the research NLT Lateral tuberal nucleus that has been performed on brain ventricles, there have NRP Nucleus of posterior recess been few studies on the morphology and evolution of the Olb Olfactory bulb brain ventricles in H. huso larvae. Olv Olfactory ventricle The central nervous system grows from a hollow tube OT Optic tectum during the embryonic period. The walls of this tube thicken OTV Tectal ventricle and form the brain and the spinal cord. The hollow tube Phr Posthabenular recess fills with the CSF of the ventricular system. This system POR Posterior recess develops laterally and forms different parts of the brain in PR Preoptic region all vertebrates, including the olfactory bulb, telencephalic PRr Preoptic recess hemispheres, midbrain, and hindbrain or cerebellum (But- pvopa Anterior part of the paraventricular organ ler and Hodos 2005). Septa Subependymal arteries In most vertebrates, the ventricular system of the brain SHypv Sulcus hypothalamicus extends laterally within the telencephalic hemispheres, Sih Sulcus intrahabenularis forming a region known as the lateral ventricle. This SlH Sulcus limitans of HIS ventricle connects to the interventricular foramen (Butler Slt Sulcus limitans telencephali and Hodos 2005), which in turn links to the third ventricle, SPR Sulcus preopticus which is a median ventricular space in the diencephalon. In Ssh Sulcus subhabenularis the dorsal region of this ventricle, the tectal ventricle SV Saccus vasculosus occupies the midbrain space. In the caudal part of the third T Telencephalon ventricle is a thin canal called the cerebral aqueduct, which TH Telencephalic hemisphere connects to the fourth ventricle in the hindbrain (Butler and thv Third ventricle Hodos 2005). The fourth ventricle extends caudally to the Tpp Periventricular nucleus of the posterior central canal of the spinal cord. tuberculum The walls of the ventricles are completely covered with tv Telencephalic ventricle a thin ependymal layer and meninx, which form the tela VC Valvula cerebelli chorioidea or choroid plexus. This structure consists of VIIv Facial viscerosensory lobe blood vessels and produces cerebrospinal fluid (CSF) in Vnl Vagal viscerosensory lobe the ventricular system (Broglio et al. 2003). CSF circu- lates in the ventricular system, protecting the brain against physical trauma and other damage (Butler and Hodos 2005). Introduction While there have been studies of ventricular develop- ment in the teleost brain (Ekstrom et al. 2001), the evo- H. huso (Beluga sturgeon) is an especially long-lived sea- lution of the CNS in sturgeons (Von Kupffer 1906), the dwelling fish species that is well-known commercially due ontogenesis of the brain in A. ruthenus (Nieuwenhuys to the high value of H. huso caviar (Birstein et al. 1998), 1962 and 1963), and brain development in A. naccari although it is also an important source of valuable fish (Vazquez et al. 2002), there has been no research into the meat. Adult H. huso are not deep-sea fish (they usually live evolution of the brain ventricles in H. huso larvae. in the middle depths), these pelagic fishes require a rela- Therefore, in the research reported in the present paper, tively low-light environment and make use of special we studied ventricular morphogenesis and volume in 1- to senses; for instance, they can perceive the Earth’s magnetic 54-day-old H. huso larvae. Ventricular volumes were field and without using other environmental factors to estimated by Cavalieri’s principle, which is often used in navigate while migrating (Kimley et al. 2002). Other stereological research to estimate organ volumes (Gun- sturgeon species are normally benthic—they swim along dersen and Jensen 1987). In this approach, sections of the the sea bottom (Bergquist 1932). Obviously, this difference organ are prepared and then sampled at regular intervals. between the behavior of H. huso and that of other sturgeon A point grid is then applied to each sampled section, and species is reflected in differences in brain development the number of grid points that occur within the section is between these species (Bemis et al. 1997). noted. Knowledge of the number of grid points within The brain structure of a ray-finned fish changes during each section as well as the interval between sections the development of the fish (Northcutt 1978 and 1996), and allows the volume of the organ of interest to be estimated these changes correlate with key points in the development (Howard and Reed 1998). 123 Author's personal copy Brain ventricle development in H. huso (Beluga sturgeon) larvae Materials and methods The olfactory ventricle was seen as a cranial extension of the telencephalic ventricle that was covered with a thin For this research, we obtained 40 samples of H. huso layer of ependymal cells (Fig. 2). Its expansion to the larvae aged 1, 3, 6, 15, 21, and 54 days post-hatch (dph) olfactory bulb developed with age. Adjacent to this from the Shahid Marjani Aghghela propagation station in extension, the inner cell layer of the olfactory bulb (ic) Gorgan. Six larvae of each age were fixed in 10 % neutral (Fig. 2) was observed from 6 days old. The olfactory buffered formalin, dehydrated with an ethanol series to ventricle was followed by the lateral ventricle at the caudal 100 %, cleared in xylene, and embedded in paraffin. part of the telencephalon; these were situated inside the Because the larval brains were very small, each head was telencephalic hemispheres. fixed and sited in paraffin blocks. Blocks were cut fron- From 15 days old, the sulcus limitans telencephali tally into serial sections six microns thick from the start to appeared in the caudomedial part of the lateral ventricle the end of the specimen using a microtome. Tissue sec- and the caudal part of the pallium (Fig.
Load more

Recommended publications
  • Craniopharyngioma in the Third Ventricle: Necropsy Findings and Histogenesis
    J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.50.8.1053 on 1 August 1987. Downloaded from Journal ofNeurology, Neurosurgery, and Psychiatry 1987;50:1053-1056 Short report Craniopharyngioma in the third ventricle: necropsy findings and histogenesis KATSUZO KUNISHIO, YUJI YAMAMOTO, NORIO SUNAMI, SHOJI ASARI, TADAATSU AKAGI,* YUJI OHTSUKI* From the Department ofNeurological Surgery, Matsuyama Shimin Hospital, Ehime and Department Of Pathology,* Kochi Medical School, Kochi, Japan SUMMARY A case of craniopharyngioma confined within the third ventricle with necropsy is re- ported. A stalk-like structure in this tumour was present in the wall of the third ventricle at its base. It is suggested that this tumour might have arisen from the remnants of Rathke's pouch persisting in the tuber cinereum. Craniopharyngiomas have been considered to be de- or slightly low-density mass (mean Hounsfield units (HU): rived from remnants of Rathke's pouch, which is 30) occupying the third ventricle, and the lateral ventricles Protected by copyright. thought to lie in the superior aspect of the pituitary were dilated. With contrast medium there was homogeneous enhancement (mean HU: 68) of the entire mass situated in stalk and infundibulum. They commonly occupy the the third ventricle. Coronal CT scans showed that an en- suprasellar cistern and may occasionally spread into hanced mass seemed to be separated from the sella turcica the anterior, middle, or posterior cranial fossae, as and confined to the third ventricle. Conray ventriculography well as into the sella turcica. Craniopharyngioma showed a large mass almost completely filling the anterior confined to the third ventricle, however, is rare.
    [Show full text]
  • Neuroanatomy Dr
    Neuroanatomy Dr. Maha ELBeltagy Assistant Professor of Anatomy Faculty of Medicine The University of Jordan 2018 Prof Yousry 10/15/17 A F B K G C H D I M E N J L Ventricular System, The Cerebrospinal Fluid, and the Blood Brain Barrier The lateral ventricle Interventricular foramen It is Y-shaped cavity in the cerebral hemisphere with the following parts: trigone 1) A central part (body): Extends from the interventricular foramen to the splenium of corpus callosum. 2) 3 horns: - Anterior horn: Lies in the frontal lobe in front of the interventricular foramen. - Posterior horn : Lies in the occipital lobe. - Inferior horn : Lies in the temporal lobe. rd It is connected to the 3 ventricle by body interventricular foramen (of Monro). Anterior Trigone (atrium): the part of the body at the horn junction of inferior and posterior horns Contains the glomus (choroid plexus tuft) calcified in adult (x-ray&CT). Interventricular foramen Relations of Body of the lateral ventricle Roof : body of the Corpus callosum Floor: body of Caudate Nucleus and body of the thalamus. Stria terminalis between thalamus and caudate. (connects between amygdala and venteral nucleus of the hypothalmus) Medial wall: Septum Pellucidum Body of the fornix (choroid fissure between fornix and thalamus (choroid plexus) Relations of lateral ventricle body Anterior horn Choroid fissure Relations of Anterior horn of the lateral ventricle Roof : genu of the Corpus callosum Floor: Head of Caudate Nucleus Medial wall: Rostrum of corpus callosum Septum Pellucidum Anterior column of the fornix Relations of Posterior horn of the lateral ventricle •Roof and lateral wall Tapetum of the corpus callosum Optic radiation lying against the tapetum in the lateral wall.
    [Show full text]
  • Ventriculomegaly
    Great Ormond Street Hospital for Children NHS Foundation Trust: Information for Families Ventriculomegaly This information sheet from Great Ormond Street Hospital (GOSH) explains the causes, symptoms and treatment of ventriculomegaly and hydrocephalus and where to get help. Ventricles are cavities within the brain filled Without signs of increased pressure in the with cerebro-spinal fluid (CSF) acting as a brain (hydrocephalus), ventriculomegaly most ‘cushion’. CSF also supplies nutrients to the likely will not cause any problems. However, brain. The brain has four ventricles: two it can be linked with hydrocephalus and other lateral ventricles, the third ventricle and the problems. Ventriculomegaly can be diagnosed fourth ventricle. during pregnancy and occurs in around two CSF is created within the brain and flows from per cent of all pregnancies. the lateral ventricles into the third ventricle. It then flows through a narrow tube (the What causes cerebral aqueduct) into the fourth ventricle which lies towards the base of the brain. From ventriculomegaly? the fourth ventricle, it flows around the spinal In many cases, we do not know what causes cord and over the surface of the brain before ventriculomegaly (in the absence of any raised being re-absorbed. CSF pressure) but it can occur if there has been Ventriculomegaly is the medical term used to brain damage for any reason leading to loss describe enlargement of the ventricles of the of brain tissue. Often however it is a “chance” brain. Hydrocephalus is the term used when finding and when the ventricles are only a enlargement of the ventricles has been caused little enlarged of little significance.
    [Show full text]
  • Estimation of Ventricles Size of Human Brain by Magnetic Resonance
    Original Research Article Original Research Article Journal of Gandaki Medical College Nepal Estimation of ventricles size of human brain by Magnetic Resonance Imaging in Nepalese Population: A retrospective study Sushma Singh1* iD , Bhoj Raj Sharma2, Urusha Prajapati3, Pujan Sharma4, Manoj Bhatta3, Nawaraj Poudel2 1Lecturer/B.Sc MIT Programe Coordinator, Department of Radiology Gandaki Medical College 2Lecturer, Department of Radiology Gandaki Medical College 3Radiological Technologist 4Associate Professor, Department of Radiology Gandaki Medical College ABSTRACT Background and Objective: data Magnetic resonance imaging (MRI) provides image acquisition of three-dimensional and measurement in any chosen imaging plane. Objective of this study is to assess the size of ventricles of the dimensions among different age and gender. Materials and methods: This is a cross-sectional retrospective study done brain of normal Nepalese people and establish the range of size of the ventricular system and compute the ventricular at Gandaki Medical College, Pokhara. A total of 106 MRI scan data of healthy individuals were collected over a period of seven months between March to September 2019. Patients ranged between eight and eighty years of age with 58 males and 48 females. Measurements of the mean of bifrontal diameter (BFD), bihemispheric diameter (BHD), third ventricle Result: transverse dimension (TVTD), fourth ventricle antero-posterior dimension (FVAP), fourth ventricle width (FVW), and frontal horn ratio (FHR) were done. The mean of BFD, BHD, TVTD, FVAP, FVW, and FHR were found to be 3.05 ± 0.10 cm, 10.11 ± 0.40 cm, 0.43 ± 0.11 cm, 0.90 ± 0.11 cm, 1.22 ± 0.12 cm, and 0.30 ± 0.01 cm, respectively.
    [Show full text]
  • Brain Anatomy
    BRAIN ANATOMY Adapted from Human Anatomy & Physiology by Marieb and Hoehn (9th ed.) The anatomy of the brain is often discussed in terms of either the embryonic scheme or the medical scheme. The embryonic scheme focuses on developmental pathways and names regions based on embryonic origins. The medical scheme focuses on the layout of the adult brain and names regions based on location and functionality. For this laboratory, we will consider the brain in terms of the medical scheme (Figure 1): Figure 1: General anatomy of the human brain Marieb & Hoehn (Human Anatomy and Physiology, 9th ed.) – Figure 12.2 CEREBRUM: Divided into two hemispheres, the cerebrum is the largest region of the human brain – the two hemispheres together account for ~ 85% of total brain mass. The cerebrum forms the superior part of the brain, covering and obscuring the diencephalon and brain stem similar to the way a mushroom cap covers the top of its stalk. Elevated ridges of tissue, called gyri (singular: gyrus), separated by shallow groves called sulci (singular: sulcus) mark nearly the entire surface of the cerebral hemispheres. Deeper groves, called fissures, separate large regions of the brain. Much of the cerebrum is involved in the processing of somatic sensory and motor information as well as all conscious thoughts and intellectual functions. The outer cortex of the cerebrum is composed of gray matter – billions of neuron cell bodies and unmyelinated axons arranged in six discrete layers. Although only 2 – 4 mm thick, this region accounts for ~ 40% of total brain mass. The inner region is composed of white matter – tracts of myelinated axons.
    [Show full text]
  • GLP-1 Action in the Mouse Bed Nucleus of the Stria Terminalis
    Neuropharmacology 131 (2018) 83e95 Contents lists available at ScienceDirect Neuropharmacology journal homepage: www.elsevier.com/locate/neuropharm GLP-1 action in the mouse bed nucleus of the stria terminalis Diana L. Williams a, Nicole A. Lilly a, Ian J. Edwards b, Pallas Yao b, 1, James E. Richards b, * Stefan Trapp b, a Psychology Department & Program in Neuroscience, Florida State University, USA b Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London, WC1E 6BT, UK article info abstract Article history: Glucagon-like peptide-1 (GLP-1) injected into the brain reduces food intake. Similarly, activation of Received 6 June 2017 preproglucagon (PPG) cells in the hindbrain which synthesize GLP-1, reduces food intake. However, it is Received in revised form far from clear whether this happens because of satiety, nausea, reduced reward, or even stress. Here we 13 October 2017 explore the role of the bed nucleus of the stria terminalis (BNST), an area involved in feeding control as Accepted 3 December 2017 well as stress responses, in GLP-1 responses. Available online 6 December 2017 Using cre-expressing mice we visualized projections of NTS PPG neurons and GLP-1R-expressing BNST cells with AAV-driven Channelrhodopsin-YFP expression. The BNST displayed many varicose YFPþ PPG Keywords: Glucagon-like peptide-1 receptor axons in the ventral and less in the dorsal regions. Mice which express RFP in GLP-1R neurons had þ Electrophysiology RFP cells throughout the BNST with the highest density in the dorsal part, suggesting that PPG neuron- Channelrhodopsin derived GLP-1 acts in the BNST.
    [Show full text]
  • Gender Related Differences in Third Ventricle Parameters with Correlation to Cerebrum Size - a Study on Head CT Scans
    International Journal of Health Sciences and Research www.ijhsr.org ISSN: 2249-9571 Original Research Article Gender Related Differences in Third Ventricle Parameters with Correlation to Cerebrum Size - A Study on Head CT Scans Poonam Patnaik1, Vishram Singh2, Dalvinder Singh3, Satbir Singh4 1Assistant Professor, Department Of Anatomy, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India. Research Scholar at SMC &H, NCR. 2Professor and Head, Department Of Anatomy, Santosh Medical College and Hospital, Ghaziabad, NCR, India 3Associate Professor, Department Of Anatomy, Jamia Millia Islamia, New Delhi, India. 4Director Professor, Department Of Radiology and Imaging, G.B.Pant Hospital, New Delhi, India. Corresponding Author: Poonam Patnaik Received: 19/07/2015 Revised: 14/10/2015 Accepted: 15/10/2015 ABSTRACT Background: The ventricular system of brain can be visualized by using modern computerized x-ray tomography, an easy and safe available noninvasive technology and it can be used as a screening procedure for many pathological conditions. Cerebral ventricular enlargement has been associated with many neurological disorders. Whether this enlargement is primary or secondary to these pathological conditions remains controversial. To define such enlargement, one must have measurements in normal subjects (controls). Present article describes the third ventricle parameters correlated to cerebrum dimensions as part of PhD thesis work of 1st author under the supervision of 2nd, 3rd and 4th author. Material and Methods: Fifty nine apparently normal axial non-contrast head CT scans of patients (32 males, 27 females) with age range between 5-70 years were subjected to morphometric measurements using dicom image software. Third ventricle width (TVW), third ventricle sylvian fissure distance index (TSFI), third ventricle ratio (TVR) were calculated.
    [Show full text]
  • Computed Tomography of the Brain Stem with Intrathecal Metrizamide. Part I: the Normal Brain Stem
    Computed Tomography of the Brain Stem with Intrathecal Metrizamide. Part I: The Normal Brain Stem Michel E. Mawad 1 Detailed anatomy of the brain stem and cervicomedullary junction can be accurately A. John Silver demonstrated with metrizamide computed tomographic cisternography. Specifically. Sadek K. Hilal surface anatomy is unusually well outlined. Nine distinct and easily recognizable levels S. Ramaiah Ganti of section are described: four levels in the medulla, three in the pons, and two in the mesencephalon. Surface features of the brain stem, fine details in the floor of the fourth ventricle, cranial nerves, and vascular structures are shown and discussed. Reliably accurate imaging of the brain stem and cervicomedullary junction has now become available using high-resolution computed tomographic (CT) scan­ ning following intrathecal admini stration of metrizamide [1 -6]. The demonstration of surface features of the brain stem such as the ventral fissure, ventrolateral su lcus, pyramids, and olivary protuberance has become commonplace; suc h details have not been routinely demonstrable in the past. Many authors [1, 2] have already emphasized the value of metrizamide CT cisternography and its superiority to both angiography and pneumoencephalog­ raphy. These latter procedures rely on subtle displacement of vessels or distor­ tion of the air-filled fourth ventricle and posterior fossa cisterns. Compared with air, metrizamide spreads much more readily in th e entire subarachnoid space without the problem of meniscus formation or " air lock. " CT permits the sepa­ ration of the various collections of contrast agent and avoids th e superimposition of features encountered in nontomographic contrast studies. Improved visualization of the details of the brain stem by metrizamide CT has allowed the detection of subtle morphologic changes in the brain stem and subarachnoid space not previously appreciated.
    [Show full text]
  • Hydrocephalus Really Communicating? Prospective Study on the Value of 3D-Constructive Interference in Steady State ORIGINAL RESEARCH Sequence at 3T
    Published July 30, 2009 as 10.3174/ajnr.A1726 Is All “Communicating” Hydrocephalus Really Communicating? Prospective Study on the Value of 3D-Constructive Interference in Steady State ORIGINAL RESEARCH Sequence at 3T A. Dinçer BACKGROUND AND PURPOSE: 3D-constructive interference in steady state (3D-CISS) sequence has S. Kohan been used to assess the CSF pathways. The aim of this study was to investigate the additive value of 3D-CISS compared with conventional sequences in the diagnosis of obstructive membranes in M.M. O¨ zek hydrocephalus. MATERIALS AND METHODS: A total of 134 patients with hydrocephalus underwent MR imaging examination with a 3T unit consisting of turbo spin-echo, 3D-CISS, and cine phase-contrast (cine PC) sequences. 3D-CISS was used to assess obstructive membranes in CSF pathways compared with other sequences. Cine PC, follow-up imaging, and surgical findings were used to confirm obstructive membranes. RESULTS: Comparing the number of noncommunicating cases by using the conventional and 3D-CISS images, we found 26 new cases (19.4%) of 134 cases that were previously misdiagnosed as communicating hydrocephalus by conventional images. 3D-CISS sequence identified obstructive membranes invisible in other sequences, which facilitated selection of neuroendoscopy in the treat- ment of 31 patients (23.1%) in total who would have been otherwise treated with shunt insertion. These patients included 26 newly diagnosed noncommunicating cases after demonstration of intra- ventricular and/or fourth ventricular outlet membranes and 5 cases of communicating hydrocephalus with obstructing cisternal membranes. There were obstructions of the foramina of Luschka in 22 of 26 newly found noncommunicating cases.
    [Show full text]
  • Endoscopic Navigation of the Fourth Ventricle
    Neurosurg Focus 19 (6):E12, 2005 Endoscopic navigation of the fourth ventricle Technical note and preliminary experience PIERLUIGI LONGATTI, M.D., LUCA BASALDELLA, M.D., ALBERTO FELETTI, M.D., ALESSANDRO FIORINDI, M.D., AND DOMENICO BILLECI, M.D. Department of Neurosurgery, Treviso Regional Hospital, University of Padova, Italy Transaqueductal navigation of the fourth ventricle has long been considered dangerous and of no clinical relevance. After the refinement of the endoscopic technique and supported by the extensive experience gained at the authors’ in- stitution since 1994, endoscopic exploration of the fourth ventricle has been performed by the same surgeon in 54 pa- tients. In all cases reviewed, endoscopic navigation of the fourth ventricle was successfully performed with no related neurological deficit. This preliminary experience shows the feasibility of transaqueductal navigation of the fourth ven- tricle, which is made possible by the use of small, flexible endoscopes in expert hands. KEY WORDS • neuroendoscopy • fourth ventricle • cerebral aqueduct • ventricle anatomy • hydrocephalus The transaqueductal pathway to the fourth ventricle Although it is a confined space, the cerebral aqueduct is should not be considered analogous to the Pillars of Her- endowed with its own compliance;4 the aqueductal channel cules, beyond which one dares not navigate.10 On review- yields at the passage of an instrument 4 mm in width. After ing the historical experience, we noted that the very few the endoscope crosses the opening of the cerebral aqueduct pioneers of endoscopic approaches to the aqueductal region (Fig. 1), an initial narrowing, corresponding to the superior by a frontal route preferred rigid instruments, and that the colliculi, is recognizable, and then a more dilated space extraordinary versatility of flexible scopes has not been called the aqueductal ampulla is encountered.1,4,10 A further fully exploited to achieve complete control of the ventricu- restriction is found corresponding to the inferior colliculi.
    [Show full text]
  • Figure 1. Sagittal T2W Image Showing the Location of Transverse Images. Figure 2
    Figure 1. Sagittal T2W image showing the location of transverse images. Figure 2. Transverse T2W images. (A) Transverse section at the level of the myelencephalon and caudal part of the metencephalon (cerebellum). 1, vermis of the cerebellum; 2, accessory nerve; 3, basilar artery. (B) Transverse section at the level of the myelencephalon and caudal part of the metencephalon (cerebellum). 1, lateral recess of fourth ventricle; 2, caudal cerebellar peduncle; 3, emergence of IX, X, XI cranial nerves. (C) Transverse section at the level of the myelencephalon and middle part of the metencephalon (cerebellum). 1, fourth ventricle; 2, paraflocculus of the cerebellum; 3, cochlear nucleus. (D) Transverse section at the level of the myelencephalon and rostral part of the metencephalon (cerebellum). 1, culmen; 2, lingula; 3, perilymph and endolymph of the vestibule part of the inner ear; 4, vestibulocochlear nerve. Transverse T2W images. E) Transverse section at the level of the metencephalon (cerebellum and pons). 1, culmen; 2, fourth ventricle; 3, middle cerebellar peduncle; 4, facial nerve; 5, perilymph and endolymph of the cochlea. (F) Closeup of a transverse CT image of the skull of a normal dog in bone window at the level of the cochlea. 1, facial canal; 2, rostral part of the cochlea; 3, tympanic bulla of the middle ear. (G) Transverse section at the level of the metencephalon (pons), caudal aspect of the mesencephalon (caudal colliculus), and telencephalon. 1, rostral part of cerebellum; 2, caudal colliculus (mesencephalon); 3, area of emergence of the trochlear nerve; 4, emergence of trigeminal nerve. (H) Transverse section at the level of the rostral telencephalon.
    [Show full text]
  • Three Cases of Communicating Syringomyelia Secondary to Midbrain Gliomas
    J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.40.1.80 on 1 January 1977. Downloaded from Journal ofNeurology, Neurosurgery, and Psychiatry, 1976, 40, 80-88 Three cases of communicating syringomyelia secondary to midbrain gliomas BERNARD WILLIAMS' AND W. R. TIMPERLEY From the Midland Centre for Neurosurgery and Neurology, Holly Lane, Warley, West Midlands, and the Department ofNeuropathology, Royal Infirmary, Sheffield SUMMARY Three cases ofmidbrain gliomas are described clinically and pathologically. In each case high pressure symptoms were followed by visual disturbance and the onset ofsyringomyelia symptoms bfore death. All the patients had hydrocephalus. In one case with concomitant syringobulbia, the syrinx appeared to be due to CSF communicating with the cord cavity through the tissues of the brain stem. In the other cases the communication between the CSF pathways and the syrinx was at the usual site, through the central canal at the obex. There are many reports of cases in which syringo- The patient was well until April 1967 when head- myelia has been associated with intracranial tumours. aches, aggravated by coughing and movement,Protected by copyright. Such reports have been prompted by the rarity of the recurred. He had attacks of vomiting, drowsiness, combination, and often by the belief that they shed and deterioration of vision. These tended to pass off light on the pathogenesis ofsyringomyelia. Individual quite suddenly. He also sometimes collapsed without reports have come from Lhermitte and Boveri (1912), headache; epilepsy was suspected. One such severe Tauber and Langworthy (1935), Kaelber (1952), attack was followed by diplopia for a week. There was Kosary et al.
    [Show full text]